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go-terms Description Definition Ontology
GO:0019992 diacylglycerol binding Interacting selectively with diacylglycerol, a diester of glycerol and two fatty acids. MF
GO:0019990 pteridine catabolic process The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. BP
GO:0019991 septate junction assembly The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space. BP
GO:0006598 polyamine catabolic process The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. BP
GO:0006599 phosphagen metabolic process The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. BP
GO:0006592 ornithine biosynthetic process The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. BP
GO:0006593 ornithine catabolic process The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. BP
GO:0006590 thyroid hormone generation The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. BP
GO:0006591 ornithine metabolic process The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. BP
GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. BP
GO:0006597 spermine biosynthetic process The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. BP
GO:0006595 polyamine metabolic process The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. BP
GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. BP
GO:0006624 vacuolar protein processing or maturation NA BP
GO:0006625 protein targeting to peroxisome The process of directing proteins towards the peroxisome using signals contained within the protein. BP
GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, mediated by mitochondrial proteins that recognize signals contained within the imported protein. BP
GO:0006627 mitochondrial protein processing The cleavage of proteins, usually near the N terminus, during the process of import into the mitochondrion; several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. BP
GO:0006620 posttranslational protein targeting to membrane The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. BP
GO:0006621 protein retention in ER The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. BP
GO:0006622 protein targeting to lysosome The process of directing proteins towards the lysosome using signals contained within the protein. BP
GO:0006623 protein targeting to vacuole The process of directing proteins towards the vacuole using signals contained within the protein. BP
GO:0000288 mRNA catabolic process, deadenylation-dependent decay A major pathway of mRNA degradation, that proceeds through a series of ordered steps: poly(A) tail shortening, deadenylylation-dependent decapping, and decay of the transcript body, and that can regulate mRNA stability. BP
GO:0000289 poly(A) tail shortening Shortening of the poly(A) tail of an mRNA from full length to an oligo(A) length. BP
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. MF
GO:0000286 alanine dehydrogenase activity Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+. MF
GO:0000287 magnesium ion binding Interacting selectively with magnesium (Mg) ions. MF
GO:0000280 nuclear division The partitioning of the nucleus and its genetic information. BP
GO:0000281 cytokinesis after mitosis The processes resulting in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. BP
GO:0000282 bud site selection The specification of the site where a daughter cell will form, in organisms that reproduce by budding. BP
GO:0004998 transferrin receptor activity Combining with transferrin to initiate a change in cell activity. MF
GO:0004999 vasoactive intestinal polypeptide receptor activity NA MF
GO:0004994 somatostatin receptor activity Combining with somatostatin to initiate a change in cell activity. MF
GO:0004995 tachykinin receptor activity Combining with tachykinin to initiate a change in cell activity. MF
GO:0004996 thyroid-stimulating hormone receptor activity Combining with thyroid-stimulating hormone to initiate a change in cell activity. MF
GO:0004997 thyrotropin-releasing hormone receptor activity NA MF
GO:0004990 oxytocin receptor activity Combining with oxytocin to initiate a change in cell activity. MF
GO:0004991 parathyroid hormone receptor activity Combining with parathyroid hormone to initiate a change in cell activity. MF
GO:0004992 platelet activating factor receptor activity Combining with platelet activating factor to initiate a change in cell activity. MF
GO:0004993 serotonin receptor activity Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity. MF
GO:0000756 response to pheromone during conjugation without cellular fusion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion. BP
GO:0000757 signal transduction during conjugation without cellular fusion The processes involving the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion. BP
GO:0000754 adaptation to pheromone during conjugation with cellular fusion In organisms that undergo conjugation with cellular fusion, the processes involved in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. BP
GO:0000755 cytogamy During conjugation with cellular fusion, the processes involved in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. BP
GO:0000752 agglutination during conjugation with cellular fusion During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. BP
GO:0000753 cellular morphogenesis during conjugation with cellular fusion The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion. BP
GO:0000750 pheromone-dependent signal transduction during conjugation with cellular fusion The processes involving the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. BP
GO:0000751 cell cycle arrest in response to pheromone The processes that lead to a halt in cell cycle progression (cessation of cell cycle transitions) as a result of a pheromone stimulus. BP
GO:0000758 agglutination during conjugation without cellular fusion During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. BP
GO:0000759 cellular morphogenesis during conjugation without cellular fusion The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion. BP
GO:0004666 prostaglandin-endoperoxide synthase activity Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. MF
GO:0004667 prostaglandin-D synthase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. MF
GO:0004664 prephenate dehydratase activity Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. MF
GO:0004665 prephenate dehydrogenase (NADP+) activity Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. MF
GO:0004662 CAAX-protein geranylgeranyltransferase activity Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. MF
GO:0004663 Rab-protein geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. MF
GO:0004660 protein farnesyltransferase activity Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. MF
GO:0004661 protein geranylgeranyltransferase activity Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. MF
GO:0004668 protein-arginine deiminase activity Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. MF
GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). BP
GO:0018107 peptidyl-threonine phosphorylation The posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. BP
GO:0018104 peptidoglycan-protein cross-linking The process of covalently linking peptidoglycan (murein) to proteins. BP
GO:0018105 peptidyl-serine phosphorylation The posttranslational phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. BP
GO:0018102 peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine. BP
GO:0018103 protein amino acid C-linked glycosylation The glycosylation of a peptidyl-amino acid residue at a C atom. BP
GO:0018101 peptidyl-citrulline biosynthetic process from peptidyl-arginine The hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BP
GO:0018108 peptidyl-tyrosine phosphorylation The posttranslational phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. BP
GO:0018109 peptidyl-arginine phosphorylation The posttranslational phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine. BP
GO:0051273 beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds. BP
GO:0051272 positive regulation of cell motility Any process that activates or increases the frequency, rate or extent of the movement of a cell. BP
GO:0051271 negative regulation of cell motility Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a cell. BP
GO:0051270 regulation of cell motility Any process that modulates the frequency, rate or extent of the movement of a cell. BP
GO:0051277 chromosome organization and biogenesis (sensu Bacteria) The assembly and arrangement of the bacterial chromosomes, structures composed of a very long molecule of DNA, often in circular form, and associated proteins that carries hereditary information. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0051276 chromosome organization and biogenesis The assembly and arrangement of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. BP
GO:0051275 beta-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of beta-glucans. BP
GO:0051274 beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans. BP
GO:0051279 regulation of release of sequestered calcium ion into cytoplasm Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. BP
GO:0051278 cell wall polysaccharide biosynthetic process (sensu Fungi) The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the cell wall. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0015501 glutamate:sodium symporter activity Catalysis of the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). MF
GO:0015503 glutathione-regulated potassium exporter activity Catalysis of the reaction: K+(in) + H+(out) = K+(out) + H+(in). MF
GO:0015505 uracil permease activity NA MF
GO:0015504 cytosine permease activity Catalysis of the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in). MF
GO:0015506 nucleoside:hydrogen symporter activity Catalysis of the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in). MF
GO:0015508 L-tyrosine permease activity NA MF
GO:0001909 leukocyte mediated cytotoxicity The directed killing of a target cell by a leukocyte. BP
GO:0001905 activation of membrane attack complex The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis. BP
GO:0001906 cell killing Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. BP
GO:0001907 killing by symbiont of host cells Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0001900 positive regulation by symbiont of cytolysis of host cells Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0030449 regulation of complement activation Any process that modulates the frequency, rate or extent of complement activation. BP
GO:0030448 hyphal growth Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls. BP
GO:0030445 yeast-form cell wall The cell wall surrounding a fungal cell in the single-cell, or yeast, form. CC
GO:0030447 filamentous growth The process by which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. BP
GO:0030446 hyphal cell wall The cell wall surrounding a fungal hypha. CC
GO:0016360 sensory organ precursor cell fate determination Process by which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0016361 activin receptor activity, type I Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of downstream components of the TGF-beta signaling pathway. MF
GO:0016362 activin receptor activity, type II Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of downstream components of the activin signaling pathway. MF
GO:0016363 nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane. CC
GO:0017018 myosin phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. MF
GO:0017011 protein-phycoerythrobilin linkage The linkage of the chromophore phycoerythrobilin to phycoerythrins. BP
GO:0017010 protein-phycourobilin linkage The linkage of the chromophore phycourobilin to phycoerythrins. BP
GO:0017013 protein amino acid flavinylation The addition of a flavin group to a protein amino acid. BP
GO:0017012 protein-phytochromobilin linkage The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin. BP
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway. BP
GO:0017014 protein amino acid nitrosylation The addition of a nitrosyl group to a protein amino acid. BP
GO:0017017 MAP kinase phosphatase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). MF
GO:0017016 Ras GTPase binding Interacting selectively with any member of the Ras superfamily of monomeric GTPases. MF
GO:0047920 geissoschizine dehydrogenase activity Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + NADPH. MF
GO:0047921 gentamycin 2'-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + gentamycin C1a = CoA + N2'-acetylgentamycin C1a. MF
GO:0031710 neuromedin B receptor binding Interacting selectively with a neuromedin B receptor. MF
GO:0031711 bradykinin receptor binding Interacting selectively with a bradykinin receptor. MF
GO:0031716 calcitonin receptor binding Interacting selectively with a calcitonin receptor. MF
GO:0031717 cannabinoid receptor binding Interacting selectively with a cannabinoid receptor. MF
GO:0031714 C5a anaphylatoxin chemotactic receptor binding Interacting selectively with a C5a anaphylatoxin chemotactic receptor. MF
GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding Interacting selectively with a C5L2 anaphylatoxin chemotactic receptor. MF
GO:0047928 gibberellin beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside. MF
GO:0047929 gluconate dehydratase activity Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O. MF
GO:0031718 type 1 cannabinoid receptor binding Interacting selectively with a type 1 cannabinoid receptor. MF
GO:0031719 type 2 cannabinoid receptor binding Interacting selectively with a type 2 cannabinoid receptor. MF
GO:0010056 atrichoblast fate specification The process involved in the specification of an atrichoblast. BP
GO:0018268 GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine The formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0010058 regulation of atrichoblast fate Any process that modulates atrichoblast fate specification. BP
GO:0010059 positive regulation of atrichoblast fate Any process that induces or promotes atrichoblast fate specification. BP
GO:0032432 actin filament bundle An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. CC
GO:0032433 filopodium tip The end of a filopodium distal to the body of the cell. CC
GO:0032430 positive regulation of phospholipase A2 activity Any process that activates or increases the activity of the enzyme phospholipase A2. BP
GO:0032431 activation of phospholipase A2 Any process that initiates the activity of the inactive enzyme phospholipase A2. BP
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. BP
GO:0032437 cuticular plate A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. CC
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. BP
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. BP
GO:0032438 melanosome organization and biogenesis The assembly and arrangement of a melanosome. BP
GO:0032439 endosome localization The processes by which endosomes are transported to, and/or maintained in, a specific location within the cell. BP
GO:0005865 striated muscle thin filament Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils. CC
GO:0008503 benzodiazepine receptor activity Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. MF
GO:0008502 melatonin receptor activity Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. MF
GO:0008507 sodium:iodide symporter activity Catalysis of the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in). MF
GO:0008506 sucrose:hydrogen symporter activity Catalysis of the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in). MF
GO:0008504 monoamine transporter activity Enables the directed movement of monoamines, organic compounds containing one amino group, into, out of, within or between cells. MF
GO:0000089 mitotic metaphase Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles. BP
GO:0051422 negative regulation of endo-1,4-beta-xylanase activity Any process that stops or reduces the rate of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans. BP
GO:0008509 anion transporter activity Enables the directed movement of atoms or small molecules with a negative charge into, out of, within or between cells. MF
GO:0008508 bile acid:sodium symporter activity Catalysis of the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). MF
GO:0051423 positive regulation of endo-1,4-beta-xylanase activity Any process that activates or increases the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans. BP
GO:0045386 positive regulation of interleukin-19 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19. BP
GO:0045387 regulation of interleukin-20 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20. BP
GO:0045384 regulation of interleukin-19 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19. BP
GO:0045385 negative regulation of interleukin-19 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19. BP
GO:0045382 negative regulation of interleukin-18 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18. BP
GO:0045383 positive regulation of interleukin-18 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18. BP
GO:0045380 positive regulation of interleukin-17 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17. BP
GO:0045381 regulation of interleukin-18 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18. BP
GO:0051284 positive regulation of sequestering of calcium ion Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. BP
GO:0045388 negative regulation of interleukin-20 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20. BP
GO:0045389 positive regulation of interleukin-20 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20. BP
GO:0051285 cell cortex of cell tip The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell. CC
GO:0051282 regulation of sequestering of calcium ion Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. BP
GO:0051283 negative regulation of sequestering of calcium ion Any process that stops, prevents or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. BP
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol Any process that stops, prevents or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. BP
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. BP
GO:0045658 regulation of neutrophil differentiation Any process that modulates the frequency, rate or extent of neutrophil differentiation. BP
GO:0045659 negative regulation of neutrophil differentiation Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil differentiation. BP
GO:0045650 negative regulation of macrophage differentiation Any process that stops, prevents or reduces the frequency, rate or extent of macrophage differentiation. BP
GO:0045651 positive regulation of macrophage differentiation Any process that activates or increases the frequency, rate or extent of macrophage differentiation. BP
GO:0045652 regulation of megakaryocyte differentiation Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. BP
GO:0045653 negative regulation of megakaryocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of megakaryocyte differentiation. BP
GO:0045654 positive regulation of megakaryocyte differentiation Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. BP
GO:0045655 regulation of monocyte differentiation Any process that modulates the frequency, rate or extent of monocyte differentiation. BP
GO:0045656 negative regulation of monocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of monocyte differentiation. BP
GO:0045657 positive regulation of monocyte differentiation Any process that activates or increases the frequency, rate or extent of monocyte differentiation. BP
GO:0042390 gibberellic acid mediated signaling, G-alpha-independent A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. BP
GO:0042391 regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. BP
GO:0042392 sphingosine-1-phosphate phosphatase activity Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. MF
GO:0042393 histone binding Interacting selectively with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. MF
GO:0042394 ecdysis (sensu Protostomia and Nematoda) The shedding of the old cuticular fragments during the molting cycle. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317), and the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0042395 ecdysis (sensu Nematoda) The shedding of the old cuticular fragments during the molting cycle, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0042396 phosphagen biosynthetic process The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. BP
GO:0042397 phosphagen catabolic process The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. BP
GO:0042398 amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. BP
GO:0042399 ectoine metabolic process The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. BP
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. MF
GO:0003676 nucleic acid binding Interacting selectively with any nucleic acid. MF
GO:0003677 DNA binding Interacting selectively with DNA (deoxyribonucleic acid). MF
GO:0003678 DNA helicase activity Catalysis of the hydrolysis of ATP to unwind the DNA helix at the replication fork, allowing the resulting single strands to be copied. MF
GO:0030874 nucleolar chromatin The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA. CC
GO:0030875 rDNA protrusion Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining. CC
GO:0030876 interleukin-20 receptor complex Complex that binds interleukin-20; comprises an alpha and a beta subunit. CC
GO:0030877 beta-catenin destruction complex A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. CC
GO:0030870 Mre11 complex Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins. CC
GO:0030871 cytosolic ribosome (sensu Archaea) The ribosome of an archaeal cell; the archael ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit. As in, but not restricted to, the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0030872 cytosolic large ribosomal subunit (sensu Archaea) The large subunit of an archaeal ribosome; has a sedimentation coefficient of 50S. As in, but not restricted to, the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0030873 cytosolic small ribosomal subunit (sensu Archaea) The small subunit of an archaeal ribosome; has a sedimentation coefficient of 30S. As in, but not restricted to, the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0030878 thyroid gland development The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. BP
GO:0030879 mammary gland development The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. BP
GO:0050814 epothilone biosynthetic process The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. BP
GO:0050815 phosphoserine binding Interacting selectively with a phosphorylated serine residue within a protein. MF
GO:0050816 phosphothreonine binding Interacting selectively with a phosphorylated threonine residue within a protein. MF
GO:0050817 coagulation The process by which a fluid solution, or part of it, changes into a solid or semisolid mass. BP
GO:0050810 regulation of steroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. BP
GO:0050811 GABA receptor binding Interacting selectively with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. MF
GO:0050812 regulation of acyl-CoA biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. BP
GO:0050813 epothilone metabolic process The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer. BP
GO:0018199 peptidyl-glutamine modification The modification of peptidyl-glutamine. BP
GO:0050818 regulation of coagulation Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass. BP
GO:0050819 negative regulation of coagulation Any process that stops, prevents or reduces the frequency, rate or extent of coagulation. BP
GO:0018198 peptidyl-cysteine modification The modification of peptidyl-cysteine. BP
GO:0001629 G-protein receptor 45-like receptor activity NA MF
GO:0001628 gastropyloric receptor activity NA MF
GO:0018191 peptidyl-serine octanoylation The posttranslational octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin. BP
GO:0046673 negative regulation of retinal cell programmed cell death (sensu Endopterygota) Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0046672 positive regulation of retinal cell programmed cell death (sensu Endopterygota) Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0046671 negative regulation of retinal programmed cell death Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. BP
GO:0046670 positive regulation of retinal programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. BP
GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. BP
GO:0046676 negative regulation of insulin secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of insulin. BP
GO:0046675 induction of retinal cell programmed cell death (sensu Endopterygota) A process which directly activates any of the steps required for programmed cell death in the retina. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0046674 induction of retinal programmed cell death A process which directly activates any of the steps required for programmed cell death in the retina. BP
GO:0046679 response to streptomycin A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. BP
GO:0046678 response to bacteriocin A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation. BP
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. CC
GO:0002100 tRNA wobble adenosine to inosine editing The process whereby an adenosine in position 34 of a tRNA is post-transcriptionally corverted to inosine. BP
GO:0048942 posterior lateral line nerve glial cell morphogenesis during differentiation The process by which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initally relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve. BP
GO:0048941 posterior lateral line nerve glial cell development The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0048940 anterior lateral line nerve glial cell morphogenesis during differentiation The process by which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initally relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve. BP
GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. CC
GO:0030128 clathrin coat of endocytic vesicle A clathrin coat found on an endocytic vesicle. CC
GO:0030129 clathrin coat of synaptic vesicle A clathrin coat found on a synaptic vesicle. CC
GO:0030122 AP-2 adaptor complex An adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. CC
GO:0030123 AP-3 adaptor complex An adaptor complex found associated with endosomal membranes; it is not clear whether AP-3 forms clathrin coats in vivo. CC
GO:0030120 vesicle coat A membrane coat found on a coated vesicle. CC
GO:0030121 AP-1 adaptor complex An adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. CC
GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. CC
GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. CC
GO:0030124 AP-4 adaptor complex An adaptor complex found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo. CC
GO:0030125 clathrin vesicle coat A clathrin coat found on a vesicle. CC
GO:0031839 type 1 neuromedin U receptor binding Interacting selectively with a type 1 neuromedin U receptor. MF
GO:0031838 haptoglobin-hemoglobin complex A protein complex formed by the stable binding of a haptoglobin to hemoglobin. CC
GO:0031837 substance K receptor binding Interacting selectively with a substance K receptor. MF
GO:0031836 neuromedin K receptor binding Interacting selectively with a neuromedin K receptor. MF
GO:0031835 substance P receptor binding Interacting selectively with a substance P receptor. MF
GO:0031834 neurokinin receptor binding Interacting selectively with a neurokinin receptor. MF
GO:0031833 type 7 serotonin receptor binding Interacting selectively with a type 7 serotonin receptor. MF
GO:0031832 type 6 serotonin receptor binding Interacting selectively with a type 6 serotonin receptor. MF
GO:0031831 type 5B serotonin receptor binding Interacting selectively with a type 5B serotonin receptor. MF
GO:0031830 type 5A serotonin receptor binding Interacting selectively with a type 5A serotonin receptor. MF
GO:0004464 leukotriene-C4 synthase activity Catalysis of the reaction: leukotriene C4 = leukotriene A4 + glutathione. MF
GO:0004465 lipoprotein lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. MF
GO:0004466 long-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF. MF
GO:0004467 long-chain-fatty-acid-CoA ligase activity Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18. MF
GO:0004460 L-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. MF
GO:0004461 lactose synthase activity Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. MF
GO:0004462 lactoylglutathione lyase activity Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. MF
GO:0004463 leukotriene-A4 hydrolase activity Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate. MF
GO:0004468 lysine N-acetyltransferase activity Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. MF
GO:0018744 limonene-1,2-epoxide hydrolase activity Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. MF
GO:0018745 epoxide hydrolase A activity Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol. MF
GO:0008978 prepilin peptidase activity Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine. MF
GO:0018747 phenanthrene-1,2-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene. MF
GO:0018740 2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity Catalysis of the reaction: 2-(2-hydroxyphenyl)benzenesulfinate + H2O = 2-hydroxybiphenyl + SO3(2-) (sulfite). MF
GO:0018741 alkyl sulfatase activity Catalysis of the reaction: dodecyl sulfate + H2O = SO4(2-) (sulfate) + H+ + 1-dodecanol. MF
GO:0018742 epoxide hydrolase B activity Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers. MF
GO:0006919 caspase activation Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. BP
GO:0008972 phosphomethylpyrimidine kinase activity Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. MF
GO:0006917 induction of apoptosis A process that directly activates any of the steps required for cell death by apoptosis. BP
GO:0006914 autophagy The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of nutrient limitation and remodeling the intracellular structure for cell differentiation. BP
GO:0006915 apoptosis A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface. BP
GO:0018748 iprodione amidohydrolase activity Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate. MF
GO:0018749 (3,5-dichlorophenylurea)acetate amidohydrolase activity Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine. MF
GO:0008974 phosphoribulokinase activity Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. MF
GO:0006911 phagocytosis, engulfment The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. BP
GO:0048055 R2/R5 development (sensu Endopterygota) The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048054 R2/R5 cell differentiation (sensu Endopterygota) The process whereby relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048057 R3/R4 development (sensu Endopterygota) The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048056 R3/R4 cell differentiation (sensu Endopterygota) The process whereby relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048051 post-embryonic eye morphogenesis (sensu Endopterygota) The process occurring after embryonic development by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. The eye is the organ of sight in the fly. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048050 post-embryonic eye morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. The eye is the organ of sight. BP
GO:0048053 R1/R6 development (sensu Endopterygota) The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048052 R1/R6 cell differentiation (sensu Endopterygota) The process whereby relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048058 corneal lens development (sensu Endopterygota) The process whose specific outcome is the progression of the corneal lens over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0021520 spinal cord motor neuron cell fate specification The process whereby a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. BP
GO:0021521 ventral spinal cord interneuron specification The process whereby a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. BP
GO:0021522 spinal cord motor neuron differentiation The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021523 somatic motor neuron differentiation The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021524 visceral motor neuron differentiation The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021525 lateral motor column neuron differentiation The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021526 medial motor column neuron differentiation The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021527 spinal cord association neuron differentiation The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021528 commissural neuron differentiation in the spinal cord The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021529 spinal cord oligodendrocyte cell differentiation The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0050065 lysine-pyruvate 6-transaminase activity Catalysis of the reaction: L-lysine + pyruvate = 2-aminoadipate 6-semialdehyde + L-alanine. MF
GO:0050064 luteolin 7-O-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + luteolin = UDP + luteolin 7-O-beta-D-glucuronide. MF
GO:0050067 lysine 2-monooxygenase activity Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O. MF
GO:0050066 lysine 2,3-aminomutase activity Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate. MF
GO:0050061 long-chain-aldehyde dehydrogenase activity Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. MF
GO:0050060 long-chain-alcohol dehydrogenase activity Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH. MF
GO:0050063 low-density lipoprotein kinase activity Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine. MF
GO:0050062 long-chain-fatty-acyl-CoA reductase activity Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH. MF
GO:0050069 lysine dehydrogenase activity Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH. MF
GO:0050068 lysine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + L-lysine = phosphate + L-homocitrulline. MF
GO:0008672 2-dehydro-3-deoxyglucarate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. MF
GO:0008675 2-dehydro-3-deoxy-phosphogluconate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. MF
GO:0043644 tetracycline biosynthetic process The formation from simpler components of tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). BP
GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. BP
GO:0002922 positive regulation of humoral immune response Any process that activates or increases the frequency, rate, or extent of a humoral immune response. BP
GO:0002921 negative regulation of humoral immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. BP
GO:0002920 regulation of humoral immune response Any process that modulates the frequency, rate, or extent of a humoral immune response. BP
GO:0043647 myo-inositol phosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5/4,6-cyclohexanehexol, with one or more phosphate groups attached. BP
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. BP
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. BP
GO:0043646 cephalosporin biosynthetic process The formation from simpler components of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria. BP
GO:0007344 pronuclear fusion The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome. BP
GO:0007346 regulation of progression through mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle. BP
GO:0007347 regulation of progression through preblastoderm mitotic cell cycle A cell cycle process that modulates the frequency, rate or extent of the progression through the preblastoderm mitotic cell cycle. BP
GO:0007340 acrosome reaction The discharge, by sperm, of a single, anterior secretory granule following their attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the disperasl of the acrosomal contents into the egg. BP
GO:0007341 penetration of zona pellucida The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. BP
GO:0007342 fusion of sperm to egg plasma membrane The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. BP
GO:0007343 egg activation The process whereby the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. BP
GO:0007348 regulation of progression through syncytial blastoderm mitotic cell cycle A cell cycle process that modulates the frequency, rate or extent of the progression through the syncytial blastoderm mitotic cell cycle. BP
GO:0007349 cellularization The enveloping of each nucleus in a syncytium by a plasma membrane. BP
GO:0035055 regulation of nuclear mRNA splicing via U2-type spliceosome Any process that modulates the frequency, rate or extent of mRNA splicing via a U2-type spliceosome. BP
GO:0035054 embryonic heart tube anterior/posterior pattern formation The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta. BP
GO:0030023 extracellular matrix constituent conferring elasticity A component of the extracellular matrix that enables the matrix to recoil after transient stretching. MF
GO:0035053 heart proper cell fate commitment (sensu Insecta) The commitment of cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0035052 aortic cell fate commitment (sensu Insecta) The commitment of cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0052339 disassembly by organism of cell wall of other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052338 disassembly by host of symbiont cell wall The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052333 modification by organism of cell wall of other organism during symbiotic interaction The process by which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052332 modification by organism of cell membrane in other organism during symbiotic interaction The process by which an organism effects a change in the structure or function of the cell membrane of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052331 hemolysis by organism of red blood cells in other organism during symbiotic interaction The processes by which an organism effects hemolysis, the lytic destruction of red blood cells with the release of intracellular hemoglobin, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052330 positive regulation by organism of programmed cell death in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052337 modification by host of symbiont cell membrane The process by which an organism effects a change in the structure or function of the symbiont cell membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052336 modification by host of symbiont cell wall The process by which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052335 modification by host of symbiont cytoskeleton The process by which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052334 modification by organism of cytoskeleton in other organism during symbiotic interaction The process by which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0006127 glycerophosphate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle. BP
GO:0006125 thioredoxin pathway NA BP
GO:0006124 ferredoxin metabolic process The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each. BP
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. BP
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. BP
GO:0006121 mitochondrial electron transport, succinate to ubiquinone The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II. BP
GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. BP
GO:0018811 cyclohex-1-ene-1-carboxyl-CoA hydratase activity Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA. MF
GO:0018812 3-hydroxyacyl-CoA dehydratase activity Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). MF
GO:0055003 cardiac myofibril assembly The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. BP
GO:0046014 negative regulation of T cell homeostatic proliferation Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation. BP
GO:0018814 phenylacetaldoxime dehydratase activity Catalysis of the reaction: Z-phenylacetaldoxime = H2O + phenylacetonitrile. MF
GO:0055005 ventricular cardiac myofibril development The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. BP
GO:0018816 2-hydroxyisobutyrate dehydratase activity Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate. MF
GO:0018817 2-oxo-hept-3-ene-1,7-dioate hydratase activity Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. MF
GO:0018818 acetylene hydratase activity Catalysis of the reaction: acetylene + H2O = acetaldehyde. MF
GO:0046013 regulation of T cell homeostatic proliferation Any process that modulates the frequency, rate or extent of resting T cell proliferation. BP
GO:0018819 lactoyl-CoA dehydratase activity Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O. MF
GO:0046011 regulation of oskar mRNA translation Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex. BP
GO:0005478 intracellular transporter activity Enables the directed movement of substances within a cell. MF
GO:0005476 carnitine:acyl carnitine antiporter activity Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial). MF
GO:0005477 pyruvate carrier activity NA MF
GO:0005471 ATP:ADP antiporter activity Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). MF
GO:0005472 FAD carrier activity NA MF
GO:0048019 receptor antagonist activity Interacts with receptors to reduce the action of another ligand, the agonist. MF
GO:0016971 flavin-linked sulfhydryl oxidase activity Catalysis of the formation of disulfide bridges. MF
GO:0016973 poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. BP
GO:0016972 thiol oxidase activity Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. MF
GO:0016974 sodium channel auxiliary protein activity NA MF
GO:0016977 chitosanase activity Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan. MF
GO:0016976 NEDD8 conjugating enzyme activity Catalysis of the covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to other proteins. MF
GO:0016979 lipoate-protein ligase activity Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein. MF
GO:0016978 lipoate-protein ligase B activity NA MF
GO:0047010 hydroxycyclohexanecarboxylate dehydrogenase activity Catalysis of the reaction: NAD+ + (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate = NADH + H+ + (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate. MF
GO:0047011 2-dehydropantolactone reductase (A-specific) activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. MF
GO:0015776 capsular polysaccharide transport The directed movement of capsular polysaccharides into, out of, within or between cells. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. BP
GO:0015777 teichoic acid transport The directed movement of teichoic acid into, out of, within or between cells. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. BP
GO:0047702 beta-lysine 5,6-aminomutase activity Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate. MF
GO:0015775 beta-glucan transport The directed movement of beta-glucans into, out of, within or between cells. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. BP
GO:0015772 oligosaccharide transport The directed movement of oligosaccharides into, out of, within or between cells. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. BP
GO:0047705 bilirubin oxidase activity Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O. MF
GO:0047706 biochanin-A reductase activity Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + NADPH. MF
GO:0047707 biotin-CoA ligase activity Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA. MF
GO:0047708 biotinidase activity Catalysis of the reaction: biotin amide + H2O = biotin + NH3. MF
GO:0047709 bis(2-ethylhexyl)phthalate esterase activity Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexyl phthalate + 2-ethylhexan-1-ol. MF
GO:0015778 hexuronide transport The directed movement of hexuronide into, out of, within or between cells. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate. BP
GO:0015779 glucuronoside transport The directed movement of glucuronosides into, out of, within or between cells. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. BP
GO:0043410 positive regulation of MAPKKK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. BP
GO:0043411 myopalladin binding Interacting selectively with myopalladin, a myofibrillar protein with titin-like Ig domains. MF
GO:0043412 biopolymer modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties. BP
GO:0043413 biopolymer glycosylation The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. BP
GO:0043414 biopolymer methylation The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. BP
GO:0043415 positive regulation of skeletal muscle regeneration Any process that activates or increase the rate of skeletal muscle regeneration. BP
GO:0043416 regulation of skeletal muscle regeneration Any process that modulates the frequency, rate or extent of skeletal muscle. BP
GO:0043417 negative regulation of skeletal muscle regeneration Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle regeneration. BP
GO:0043418 homocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. BP
GO:0043419 urea catabolic process The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. BP
GO:0044275 cellular carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. BP
GO:0021649 vestibulocochlear nerve structural organization The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. BP
GO:0021648 vestibulocochlear nerve morphogenesis The process by which the anatomical structure of the vestibulocochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. BP
GO:0021641 trochlear nerve structural organization The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. BP
GO:0021640 trochlear nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. BP
GO:0021643 vagus nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. BP
GO:0021642 trochlear nerve formation The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. BP
GO:0021645 vagus nerve structural organization The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. BP
GO:0021644 vagus nerve morphogenesis The process by which the anatomical structure of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. BP
GO:0021647 vestibulocochlear nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. BP
GO:0021646 vagus nerve formation The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. BP
GO:0002429 immune response-activating cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response. BP
GO:0046071 dGTP biosynthetic process The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate. BP
GO:0046070 dGTP metabolic process The chemical reactions and pathways involving dGTP, guanosine triphosphate. BP
GO:0046073 dTMP metabolic process The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). BP
GO:0046072 dTDP metabolic process The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate. BP
GO:0046075 dTTP metabolic process The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate. BP
GO:0046074 dTMP catabolic process The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate. BP
GO:0046077 dUDP metabolic process The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate. BP
GO:0046076 dTTP catabolic process The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate. BP
GO:0046079 dUMP catabolic process The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate. BP
GO:0046078 dUMP metabolic process The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate). BP
GO:0031378 plastid type II fatty acid synthase complex A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid. CC
GO:0031379 RNA-directed RNA polymerase complex A protein complex that possesses RNA-directed RNA polymerase activity. CC
GO:0045038 protein import into chloroplast thylakoid membrane The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma. BP
GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. BP
GO:0031375 type II fatty acid synthase complex A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity. CC
GO:0045030 UTP-activated nucleotide receptor activity NA MF
GO:0045031 ATP-activated nucleotide receptor activity NA MF
GO:0045032 ADP-activated nucleotide receptor activity NA MF
GO:0045033 peroxisome inheritance The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p. BP
GO:0045034 neuroblast division The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell. BP
GO:0045035 sensory organ precursor cell division The series of 4 asymmetric divisions undergone by the sensory organ precursor cells to generate the four external sensory organ cells (the socket, shaft, sheath cells and the external sense neuron), together with one multidendritic neuron. BP
GO:0045036 protein targeting to chloroplast The process of directing proteins towards the chloroplast using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved. BP
GO:0045037 protein import into chloroplast stroma The import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import. BP
GO:0047889 ferredoxin-nitrate reductase activity Catalysis of the reaction: NO2- (nitrite) + H2O + 2 oxidized ferredoxin = NO3- (nitrate) + 2 reduced ferredoxin. MF
GO:0047888 fatty-acid peroxidase activity Catalysis of the reaction: palmitate + 2 H2O2 = pentadecanal + CO2 + 3 H2O. MF
GO:0047887 farnesyl diphosphate kinase activity Catalysis of the reaction: ATP + farnesyl diphosphate = ADP + farnesyl triphosphate. MF
GO:0047886 farnesol dehydrogenase activity Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + NADPH. MF
GO:0047885 farnesol 2-isomerase activity Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol. MF
GO:0047884 FAD diphosphatase activity Catalysis of the reaction: FAD + H2O = AMP + FMN. MF
GO:0047883 ethanolamine oxidase activity Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2. MF
GO:0047882 estradiol 6-beta-monooxygenase activity Catalysis of the reaction: estradiol-17-beta + donor-H2 + O2 = 6-beta-hydroxyestradiol-17-beta + acceptor + H2O. MF
GO:0047881 estradiol 17-alpha-dehydrogenase activity Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+. MF
GO:0047880 erythrulose reductase activity Catalysis of the reaction: erythritol + NADP+ = D-erythrulose + NADPH. MF
GO:0031503 protein complex localization The processes by which a protein complex is transported to, or maintained in, a specific location. BP
GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies. CC
GO:0031501 mannosyltransferase complex A complex that posseses mannosyltransferase activity. CC
GO:0031500 Tea1 cell-end complex A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity. CC
GO:0031507 heterochromatin formation The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent. BP
GO:0031506 cell wall glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues other than as a moiety of nucleic acid. BP
GO:0031505 cell wall organization and biogenesis (sensu Fungi) The assembly and arrangement of the cell wall; as in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0031504 cell wall organization and biogenesis (sensu Bacteria) The assembly and arrangement of the cell wall; as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0031509 telomeric heterochromatin formation The assembly of chromatin into heterochromatin at the telomere. BP
GO:0031508 centric heterochromatin formation The assembly of chromatin into heterochromatin near the centromere. BP
GO:0009579 thylakoid A sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms. In prokaryotes the thylakoids are of various shapes and are attached to the plasma membrane. In eukaryotes they are flattened, membrane-bound disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. CC
GO:0009578 etioplast stroma The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA. CC
GO:0009571 proplastid stroma The space enclosed by the double membrane of a proplastid. CC
GO:0009570 chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. CC
GO:0009573 ribulose bisphosphate carboxylase complex (sensu Magnoliophyta) A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0009572 desmotubule central rod NA CC
GO:0009575 chromoplast stroma The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material. CC
GO:0009574 preprophase band A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs. CC
GO:0009577 elaioplast stroma The space enclosed by the double membrane of an elaioplast. CC
GO:0009576 leucoplast stroma The space enclosed by the double membrane of a leucoplast. CC
GO:0032087 regulation of Type IV restriction endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of a Type IV restriction endodeoxyribonuclease activity. BP
GO:0032086 regulation of Type III restriction endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of a Type III restriction endodeoxyribonuclease activity. BP
GO:0032085 regulation of Type II restriction endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of a Type II restriction endodeoxyribonuclease activity. BP
GO:0032084 regulation of Type I restriction endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of a Type I restriction endodeoxyribonuclease activity. BP
GO:0032083 negative regulation of Type IV restriction endodeoxyribonuclease activity Any process that stops or reduces the rate of Type IV restriction endodeoxyribonuclease activity. BP
GO:0032082 negative regulation of Type III restriction endodeoxyribonuclease activity Any process that stops or reduces the rate of Type III restriction endodeoxyribonuclease activity. BP
GO:0032081 negative regulation of Type II restriction endodeoxyribonuclease activity Any process that stops or reduces the rate of Type II restriction endodeoxyribonuclease activity. BP
GO:0032080 negative regulation of Type I restriction endodeoxyribonuclease activity Any process that stops or reduces the rate of Type I restriction endodeoxyribonuclease activity. BP
GO:0032089 NACHT domain binding Interacting selectively with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, an Mg(2+)-binding site and five more specific motifs. MF
GO:0032088 inhibition of NF-kappaB transcription factor Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. BP
GO:0046826 negative regulation of protein export from nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm. BP
GO:0046827 positive regulation of protein export from nucleus Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. BP
GO:0046824 positive regulation of nucleocytoplasmic transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. BP
GO:0046825 regulation of protein export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. BP
GO:0046822 regulation of nucleocytoplasmic transport Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. BP
GO:0046823 negative regulation of nucleocytoplasmic transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. BP
GO:0046820 4-amino-4-deoxychorismate synthase activity Catalysis of the reaction: chorismate + glutamine = 4-amino-4-deoxychorismic acid + glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. MF
GO:0046821 extrachromosomal DNA DNA structures that are not part of a chromosome. CC
GO:0046828 regulation of RNA import into nucleus Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus. BP
GO:0046829 negative regulation of RNA import into nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus. BP
GO:0019897 extrinsic to plasma membrane Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region. CC
GO:0019896 axon transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell axons. BP
GO:0002499 proteolysis within endosome associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation. BP
GO:0019894 kinesin binding Interacting selectively and stoichiometrically with kinesin, a cytoplasmic protein responsible for moving vesicles and organelles towards the distal end of microtubules. MF
GO:0002493 lipid antigen assembly with MHC class Ib protein complex The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family. BP
GO:0002492 peptide antigen assembly with MHC class Ib protein complex The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0002491 antigen processing and presentation of endogenous peptide antigen via MHC class II The process by which an antigen-presenting cell expresses an peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. BP
GO:0002490 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0002497 proteosomal proteolysis associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by the proteosome complex contributing to antigen processing and presentation. BP
GO:0002496 proteolysis associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation. BP
GO:0019899 enzyme binding Interacting selectively with any enzyme. MF
GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. CC
GO:0044271 nitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. BP
GO:0047069 7,8-dihydroxykynurenate 8,8a-dioxygenase activity Catalysis of the reaction: O2 + 7,8-dihydroxykynurenate = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate. MF
GO:0047068 N5,N10-methenyltetrahydromethanopterin hydrogenase activity Catalysis of the reaction: H2 + N5,N10-methenyltetrahydromethanopterin = H+ + N5,N10-methylenetetrahydromethanopterin. MF
GO:0047061 glucose-fructose oxidoreductase activity Catalysis of the reaction: fructose + beta-D-glucose = D-sorbitol + glucono-delta-lactone. MF
GO:0047060 (R)-pantolactone dehydrogenase (flavin) activity Catalysis of the reaction: acceptor + pantoyl lactone = reduced acceptor + 2-dehydropantoyl lactone. MF
GO:0047063 L-ascorbate-cytochrome-b5 reductase activity Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate. MF
GO:0047062 trans-acenaphthene-1,2-diol dehydrogenase activity Catalysis of the reaction: NADP+ + (+-)-trans-acenaphthene-1,2-diol = NADPH + H+ + acenaphthenequinone. MF
GO:0047065 sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (-)-bisdechlorogeodin. MF
GO:0047064 sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (+)-bisdechlorogeodin. MF
GO:0047067 hydrogen:quinone oxidoreductase activity Catalysis of the reaction: menaquinone + H2 = reduced menaquinone. MF
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione. MF
GO:0006325 establishment and/or maintenance of chromatin architecture The specification, formation and maintenance of the physical structure of eukaryotic chromatin. BP
GO:0006324 S-phase regulated histone modification NA BP
GO:0006323 DNA packaging Any process by which DNA and associated proteins are formed into a compact, orderly structure. BP
GO:0042581 specific granule Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. CC
GO:0042580 mannosome A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction. CC
GO:0042583 chromaffin granule Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. CC
GO:0042582 azurophil granule Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. CC
GO:0042585 germinal vesicle The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity. CC
GO:0042584 chromaffin granule membrane The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. CC
GO:0042587 glycogen granule Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. CC
GO:0042586 peptide deformylase activity Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. MF
GO:0042589 zymogen granule membrane The lipid bilayer surrounding a zymogen granule. CC
GO:0042588 zymogen granule A membrane-bound, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. CC
GO:0044270 nitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. BP
GO:0006497 protein amino acid lipidation The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein. BP
GO:0006496 protein amino acid terminal N-glycosylation The glycosylation of an N atom of a free alpha amino terminal of a peptide. BP
GO:0006494 protein amino acid terminal glycosylation The glycosylation of a free alpha-amino or alpha-carboxyl terminal of a peptide. BP
GO:0006493 protein amino acid O-linked glycosylation The formation of O-glycans by addition of glycosyl groups either to the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or to the phenol group of peptidyl-tyrosine. BP
GO:0006491 N-glycan processing The conversion of N-linked glycan structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. BP
GO:0006490 oligosaccharide-lipid intermediate assembly The cellular metabolic process by which an intermediate molecule of dolichol-P-man or dolicol-P-Glc is assembled to be used in N-linked glycosylation. BP
GO:0006499 N-terminal protein myristoylation The covalent or non-covalent attachment of a myristoyl moiety to the N-terminal amino acid residue of a protein. BP
GO:0006498 N-terminal protein lipidation The covalent or non-covalent attachment of a lipid moiety to the amino terminus of a protein. BP
GO:0015801 aromatic amino acid transport The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of, within or between cells. BP
GO:0031978 plastid thylakoid lumen The volume enclosed by a plastid thylakoid membrane. CC
GO:0031979 thylakoid lumen (sensu CyanoBacteria) The volume enclosed by a thylakoid membrane; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117). CC
GO:0031972 chloroplast intermembrane space The region between the inner and outer lipid bilayers of a chloroplast envelope. CC
GO:0031973 chromoplast intermembrane space The region between the inner and outer lipid bilayers of a chromoplast envelope. CC
GO:0031970 organelle envelope lumen The region between the inner and outer lipid bilayers of an organelle envelope. CC
GO:0031976 plastid thylakoid Any thylakoid within a plastid. CC
GO:0031977 thylakoid lumen The volume enclosed by a thylakoid membrane. CC
GO:0031974 membrane-enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. CC
GO:0031975 envelope A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer, also includes the space between layers. CC
GO:0050605 superoxide reductase activity Catalysis of the reaction: O2(-) + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin. MF
GO:0050604 taxadiene 5-alpha-hydroxylase activity Catalysis of the reaction: O2 + donor-H2 + taxa-4,11-diene = H2O + acceptor + taxa-4(20),11-dien-5-alpha-ol. MF
GO:0050607 mycothiol-dependent formaldehyde dehydrogenase activity Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+. MF
GO:0050606 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity Catalysis of the reaction: 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ = 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + H+. MF
GO:0050601 myristoyl-CoA 11-(Z) desaturase activity Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. MF
GO:0050600 myristoyl-CoA 11-(E) desaturase activity Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. MF
GO:0050603 thiophene-2-carbonyl-CoA monooxygenase activity Catalysis of the reaction: thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O. MF
GO:0050602 monoprenyl isoflavone epoxidase activity Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives. MF
GO:0050609 phosphonate dehydrogenase activity Catalysis of the reaction: phosphonate + NAD+ + H2O = phosphate + NADH + H+. MF
GO:0050608 vanillin dehydrogenase activity Catalysis of the reaction: vanillin + NAD+ + H2O = vanillate + NADH + H+. MF
GO:0005672 transcription factor TFIIA complex A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). CC
GO:0005673 transcription factor TFIIE complex A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH. CC
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. CC
GO:0005677 chromatin silencing complex Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing. CC
GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. CC
GO:0005675 transcription factor TFIIH complex A transcription factor which in humans consists of a complex of six protein subunits. Involved in transcription by RNA polymerase II and in nucleotide excision repair. CC
GO:0005678 chromatin assembly complex Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure. CC
GO:0002376 immune system process Any multicellular organismal process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. BP
GO:0002377 immunoglobulin production The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002374 cytokine secretion during immune response The regulated release of cytokines from a cell or group of cells during an immune response. BP
GO:0002375 cytokine biosynthetic process during immune response The chemical reactions and pathways resulting in the formation of a cytokine during an immune response. BP
GO:0002372 myeloid dendritic cell cytokine production Any process that contributes to cytokine production by a myeloid dendritic cell. BP
GO:0002373 plasmacytoid dendritic cell cytokine production Any process that contributes to cytokine production by a plasmacytoid dendritic cell. BP
GO:0002370 natural killer cell cytokine production Any process that contributes to cytokine production by a natural killer cell. BP
GO:0002371 dendritic cell cytokine production Any process that contributes to cytokine production by a dendritic cell. BP
GO:0002378 immunoglobulin biosynthetic process The chemical reactions and pathways resulting in the formation of immunoglobulin. BP
GO:0002379 immunoglobulin biosynthetic process during immune response The chemical reactions and pathways resulting in the formation of immunoglobulin during an immune response. BP
GO:0004235 matrilysin activity Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I). MF
GO:0004234 macrophage elastase activity Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin. MF
GO:0004237 membrane dipeptidase activity Catalysis of the hydrolysis of dipeptides. MF
GO:0004231 insulysin activity Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins. MF
GO:0004230 glutamyl aminopeptidase activity Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide. MF
GO:0004232 interstitial collagenase activity Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue. MF
GO:0004239 methionyl aminopeptidase activity Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. MF
GO:0004238 meprin A activity Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues. MF
GO:0001777 T cell homeostatic proliferation The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. BP
GO:0001776 leukocyte homeostasis The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. BP
GO:0001775 cell activation A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. BP
GO:0001774 microglial cell activation The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0001773 myeloid dendritic cell activation The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0001772 immunological synapse An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated lipid rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. CC
GO:0001771 formation of immunological synapse The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated lipid rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. BP
GO:0001770 establishment of natural killer cell polarity The directed orientation of natural killer cell signaling molecules and associated lipid rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands. BP
GO:0001779 natural killer cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a natural killer cell. BP
GO:0001778 plasma membrane repair The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. BP
GO:0052519 positive regulation by host of nutrient release from symbiont Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052518 positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by a non-apoptotic pathway in the second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052513 positive regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction The increase by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052510 positive regulation by organism of defense response of other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0003959 NADPH dehydrogenase activity Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor. MF
GO:0003958 NADPH-hemoprotein reductase activity Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. MF
GO:0003951 NAD+ kinase activity Catalysis of the reaction: ATP + NAD+ = ADP + NADP+. MF
GO:0003950 NAD+ ADP-ribosyltransferase activity Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. MF
GO:0003953 NAD+ nucleosidase activity Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. MF
GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. MF
GO:0003955 NAD(P)H dehydrogenase (quinone) activity Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)(+) + a hydroquinone. MF
GO:0003954 NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. MF
GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. MF
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine. MF
GO:0019468 nopaline catabolic process The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative. BP
GO:0019469 octopine catabolic process The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine. BP
GO:0019466 ornithine catabolic process via proline The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline. BP
GO:0019467 ornithine catabolic process, by decarboxylation The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation. BP
GO:0019464 glycine decarboxylation via glycine cleavage system NA BP
GO:0019465 aspartate transamidation The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group. BP
GO:0019462 glutamate catabolic process to fumarate, using glutaminase The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutaminase (EC:3.5.1.2). BP
GO:0019463 glycine catabolic process to creatine The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine. BP
GO:0019460 glutamate catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including fumarate. BP
GO:0019461 glutamate catabolic process to fumarate, using glutamate synthase (NADPH) The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13). BP
GO:0042808 neuronal Cdc2-like kinase binding Interacting selectively with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics. MF
GO:0042809 vitamin D receptor binding Interacting selectively with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. MF
GO:0042805 actinin binding Interacting selectively with actinin, any member of a family of proteins that crosslink F-actin. MF
GO:0042806 fucose binding Interacting selectively with fucose, a 5-carbon (pentose) sugar. MF
GO:0042807 central vacuole A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination. CC
GO:0042800 histone lysine N-methyltransferase activity (H3-K4 specific) Catalysis of the addition of a methyl group onto lysine at position 4 of the histone H3 protein. MF
GO:0042801 polo kinase kinase activity Catalysis of the addition of a phosphoric group onto a serine or threonine residue in any member of the polo kinase class of proteins. MF
GO:0042802 identical protein binding Interacting selectively with an identical protein or proteins. MF
GO:0042803 protein homodimerization activity Interacting selectively with an identical protein to form a homodimer. MF
GO:0000424 micromitophagy Degradation of a mitochondrion by microautophagy. BP
GO:0000425 macropexophagy Degradation of a peroxisome by macropexophagy. BP
GO:0000426 micropexophagy Degradation of a peroxisome by micropexophagy. BP
GO:0000427 plastid-encoded plastid RNA polymerase complex Plastid-encoded plastid RNA polymerases are plastid-encoded DNA-directed RNA polymerases that resemble eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition. CC
GO:0000420 DNA-directed RNA polymerase IVa complex RNA polymerase IVa is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVb, while the largest subunit is found only in the IVa complex. The remainder of the complex is composed of smaller subunits. CC
GO:0000421 autophagic vacuole membrane The lipid bilayer surrounding an autophagic vacuole, a double-membrane bound vesicle in which endogenous cellular material is sequestered. CC
GO:0000422 mitochondrion degradation The process by which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions, autophagy of mitochondria. BP
GO:0000423 macromitophagy Degradation of a mitochondrion by macroautophagy. BP
GO:0000428 DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity. CC
GO:0000429 regulation of transcription from RNA polymerase II promoter by carbon catabolites Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. BP
GO:0019288 isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. BP
GO:0019289 rhizobactin 1021 biosynthetic process The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. BP
GO:0019282 methionine biosynthetic process, direct, from O-acetyl-L-homoserine The direct chemical reactions and pathways resulting in the formation of methionine from other compounds, including O-acetyl-L-homoserine. BP
GO:0019283 methionine biosynthetic process from O-phospho-L-homoserine and cystathione The chemical reactions and pathways resulting in the formation of methionine from other compounds, including O-phospho-L-homoserine and cystathione. BP
GO:0019280 methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathione The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathione. BP
GO:0019281 methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathione The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathione. BP
GO:0019286 glycine betaine biosynthetic process from glycine The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine. BP
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates. BP
GO:0019284 methionine biosynthetic process from S-adenosylmethionine The chemical reactions and pathways resulting in the formation of methionine from other compounds, including S-adenosylmethionine. BP
GO:0019285 glycine betaine biosynthetic process from choline The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline. BP
GO:0051721 protein phosphatase 2A binding Interacting selectively with the enzyme protein phosphatase 2A. MF
GO:0051720 DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG. MF
GO:0051723 protein methylesterase activity Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. MF
GO:0051722 protein C-terminal methylesterase activity Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. MF
GO:0051725 protein amino acid de-ADP-ribosylation The process of removing one or more ADP-ribose residues from a protein. BP
GO:0051724 NAD transporter activity Enables the directed movement of nicotinamide adenine dinucleotide into, out of, within or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH. MF
GO:0051727 cell cycle switching, meiotic to mitotic cell cycle The process by which a cell switches cell cycle mode from meiotic to mitotic division. BP
GO:0051726 regulation of cell cycle A cell cycle process that modulates the rate, extent or mode of the cell cycle. BP
GO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle The process by which a germline cell switches cell cycle mode from mitotic to meiotic division. BP
GO:0051728 cell cycle switching, mitotic to meiotic cell cycle The process by which a cell switches cell cycle mode from mitotic to meiotic division. BP
GO:0051899 membrane depolarization The process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. BP
GO:0051898 negative regulation of protein kinase B signaling cascade Any process that stops, prevents or reduces the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. BP
GO:0051893 regulation of focal adhesion formation Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. BP
GO:0051892 negative regulation of cardioblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. BP
GO:0051891 positive regulation of cardioblast differentiation Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. BP
GO:0051890 regulation of cardioblast differentiation Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. BP
GO:0051897 positive regulation of protein kinase B signaling cascade Any process that activates or increases the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. BP
GO:0051896 regulation of protein kinase B signaling cascade Any process that modulates the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. BP
GO:0051895 negative regulation of focal adhesion formation Any process that stops, prevents or reduces the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. BP
GO:0051894 positive regulation of focal adhesion formation Any process that activates or increases the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. BP
GO:0047511 (S)-methylmalonyl-CoA hydrolase activity Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = methylmalonate + CoA. MF
GO:0047510 (S)-2-methylmalate dehydratase activity Catalysis of the reaction: (S)-2-methylmalate = 2-methylfumarate + H2O. MF
GO:0047513 1,2-alpha-L-fucosidase activity Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside. MF
GO:0047512 (S,S)-butanediol dehydrogenase activity Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + NADH + H+. MF
GO:0047515 1,3-beta-oligoglucan phosphorylase activity Catalysis of the reaction: 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. MF
GO:0047514 1,3-beta-D-glucan phosphorylase activity Catalysis of the reaction: 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. MF
GO:0047517 1,4-beta-D-xylan synthase activity Catalysis of the reaction: UDP-D-xylose + 1,4-beta-D-xylan(n) = UDP + 1,4-beta-D-xylan(n+1). MF
GO:0047516 1,3-propanediol dehydrogenase activity Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+. MF
GO:0047519 quinate dehydrogenase (pyrroloquinoline-quinone) activity Catalysis of the reaction: quinate + pyrroloquinoline-quinone = 5-dehydroquinate + reduced pyrroloquinoline-quinone. MF
GO:0047518 1-methyladenosine nucleosidase activity Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + D-ribose. MF
GO:0043201 response to leucine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus. BP
GO:0043200 response to amino acid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. BP
GO:0043203 axon hillock Portion of the neuronal cell soma from which the axon originates. CC
GO:0043202 lysosomal lumen The volume enclosed within the lysosomal membrane. CC
GO:0043205 fibril Extracellular matrix material consisting of polysaccharides and protein. CC
GO:0043204 perikaryon The portion of the cell soma (cell body) that excludes the nucleus. CC
GO:0043207 response to external biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. BP
GO:0043206 fibril organization and biogenesis The assembly and arrangement of fibrils, extracellular matrix material consisting of polysaccharides and protein. BP
GO:0043209 myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. CC
GO:0043208 glycosphingolipid binding Interacting selectively with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. MF
GO:0008062 eclosion rhythm The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn. BP
GO:0008063 Toll signaling pathway The series of molecular signals initiated by binding of a ligand to an extracellular ligand to the Toll receptor on the surface of the target cell. BP
GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds NA MF
GO:0008069 dorsal/ventral axis determination, follicular epithelium (sensu Insecta) Polarization of the follicle cells along the dorsal/ventral axis. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0045919 positive regulation of cytolysis Any process that activates or increases the frequency, rate or extent of cytolysis. BP
GO:0045918 negative regulation of cytolysis Any process that stops, prevents or reduces the frequency, rate or extent of cytolysis. BP
GO:0045913 positive regulation of carbohydrate metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. BP
GO:0045912 negative regulation of carbohydrate metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. BP
GO:0045911 positive regulation of DNA recombination Any process that activates or increases the frequency, rate or extent of DNA recombination. BP
GO:0045910 negative regulation of DNA recombination Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombination. BP
GO:0045917 positive regulation of complement activation Any process that activates or increases the frequency, rate or extent of complement activation. BP
GO:0045916 negative regulation of complement activation Any process that stops, prevents or reduces the frequency, rate or extent of complement activation. BP
GO:0045915 positive regulation of catecholamine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. BP
GO:0045914 negative regulation of catecholamine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. BP
GO:0007510 cardioblast cell fate determination Process by which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0030579 ubiquitin-dependent SMAD protein catabolic process The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome. BP
GO:0030578 PML body organization and biogenesis The assembly and arrangement of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia). BP
GO:0030570 pectate lyase activity Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. MF
GO:0030573 bile acid catabolic process The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. BP
GO:0030572 phosphatidyltransferase activity Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) moiety. MF
GO:0030575 nuclear body organization and biogenesis The assembly and arrangement of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. BP
GO:0030574 collagen catabolic process The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. BP
GO:0030577 Lands organization and biogenesis The assembly and arrangement of Lands, a class of nuclear body that react against SP140 auto-antibodies. BP
GO:0030576 Cajal body organization and biogenesis The assembly and arrangement of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors. BP
GO:0015624 ferric-enterobactin-transporting ATPase activity Catalysis of the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in). MF
GO:0015625 ferric-hydroxamate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in). MF
GO:0047474 long-chain-fatty-acid-luciferin-component ligase activity Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + pyrophosphate + AMP. MF
GO:0047475 phenylacetate-CoA ligase activity Catalysis of the reaction: CoA + phenylacetate + ATP = phenylacetyl-CoA + products of ATP breakdown. MF
GO:0015620 ferric-enterobactin transporter activity Enables the directed movement of ferric-enterobactin into, out of, within or between cells. MF
GO:0015621 ferric triacetylfusarinine C transporter activity Enables the directed movement of ferric triacetylfusarinine C into, out of, within or between cells. MF
GO:0015622 ferric-hydroxamate transporter activity Enables the directed movement of ferric-hydroxamate into, out of, within or between cells. MF
GO:0015623 iron-chelate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported. MF
GO:0008213 protein amino acid alkylation The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. BP
GO:0008212 mineralocorticoid metabolic process The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance. BP
GO:0008211 glucocorticoid metabolic process The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. BP
GO:0008210 estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. BP
GO:0008217 blood pressure regulation The process that modulates the force with which blood travels through the circulatory system. BP
GO:0008216 spermidine metabolic process The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. BP
GO:0008215 spermine metabolic process The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. BP
GO:0008214 protein amino acid dealkylation The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. BP
GO:0008219 cell death The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. BP
GO:0008218 bioluminescence The production of light by certain enzyme-catalyzed reactions in cells. BP
GO:0003924 GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate. MF
GO:0032322 ubiquinone catabolic process The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme. BP
GO:0032323 lipoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids. BP
GO:0032320 positive regulation of Ras GTPase activity Any process that activates or increases the activity of a GTPase of the Ras superfamily. BP
GO:0032321 positive regulation of Rho GTPase activity Any process that activates or increases the activity of a GTPase of the Rho family. BP
GO:0032326 Mo-molybdopterin cofactor catabolic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. BP
GO:0032327 W-molybdopterin cofactor catabolic process The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. BP
GO:0032324 molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. BP
GO:0032325 molybdopterin cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. BP
GO:0032328 alanine transport The directed movement of alanine, 2-aminopropanoic acid, into, out of, within or between cells. BP
GO:0032329 serine transport The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells. BP
GO:0019912 cyclin-dependent protein kinase activating kinase activity Increases the activity of a cyclin-dependent protein kinase (CDK). MF
GO:0019910 pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Eukaryota) A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0019911 structural constituent of myelin sheath The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. MF
GO:0019916 peptidyl-D-alanine racemization, direct The racemization of peptidyl-alanine. BP
GO:0019917 peptidyl-D-alanine racemization via peptidyl-L-serine The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine. BP
GO:0019914 cyclin-dependent protein kinase activating kinase regulator activity Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase. MF
GO:0019915 sequestering of lipid The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. BP
GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine. BP
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine. BP
GO:0002516 B cell deletion The apoptotic death of B cells which is part of B cell tolerance induction. BP
GO:0002517 T cell tolerance induction A process involving any mechanism for tolerance induction in T cells. BP
GO:0002514 B cell tolerance induction A process involving any mechanism for tolerance induction in B cells. BP
GO:0002515 B cell anergy Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction. BP
GO:0002512 central T cell tolerance induction Tolerance induction of T cells in the thymus. BP
GO:0002513 tolerance induction to self antigen Tolerance induction directed at self antigens. BP
GO:0002510 central B cell tolerance induction Tolerance induction of B cells in the bone marrow. BP
GO:0002511 central B cell receptor editing Receptor editing occurring in B cells in the bone marrow. BP
GO:0002518 lymphocyte chemotaxis across high endothelial venule The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus. BP
GO:0002519 natural killer cell tolerance induction Tolerance induction of natural killer cells. BP
GO:0031712 B1 bradykinin receptor binding Interacting selectively with a B1 bradykinin receptor. MF
GO:0031713 B2 bradykinin receptor binding Interacting selectively with a B2 bradykinin receptor. MF
GO:0047922 gentisate 1,2-dioxygenase activity Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = maleylpyruvate. MF
GO:0047923 gentisate decarboxylase activity Catalysis of the reaction: 2,5-dihydroxybenzoate = hydroquinone + CO2. MF
GO:0047924 geraniol dehydrogenase activity Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH. MF
GO:0047925 geranoyl-CoA carboxylase activity Catalysis of the reaction: ATP + geranoyl-CoA + HCO3- = ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA. MF
GO:0047926 geranyl-diphosphate cyclase activity Catalysis of the reaction: geranyl diphosphate = (+)-bornyl diphosphate. MF
GO:0047927 gibberellin-44 dioxygenase activity Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2. MF
GO:0016501 prostacyclin receptor activity Combining with prostacyclin (PGI(2)) to initiate a change in cell activity. MF
GO:0042268 regulation of cytolysis Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm. BP
GO:0042269 regulation of natural killer cell mediated cytotoxicity Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity. BP
GO:0042264 peptidyl-aspartic acid hydroxylation NA BP
GO:0042265 peptidyl-asparagine hydroxylation NA BP
GO:0042267 natural killer cell mediated cytotoxicity The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. BP
GO:0042262 DNA protection The processes by which DNA is protected from damage by, for example, oxidative stress. BP
GO:0042263 neuropeptide F receptor activity Combining with neuropeptide F, an invertebrate neuropeptide thought to play a role in neuroregulation, to initiate a change in cell activity. In many species, neuropeptide F is between 36 and 39 amino acid residues terminating in a phenylalaninamide residue. MF
GO:0006512 ubiquitin cycle The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein. BP
GO:0006513 protein monoubiquitination Addition of a single ubiquitin moiety to a protein. BP
GO:0006510 ATP-dependent proteolysis The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP. BP
GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. BP
GO:0006516 glycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. BP
GO:0006517 protein deglycosylation The removal of sugar residues from a glycosylated protein. BP
GO:0006515 misfolded or incompletely synthesized protein catabolic process The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. BP
GO:0003746 translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome. MF
GO:0003747 translation release factor activity Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. MF
GO:0003743 translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. MF
GO:0000200 inactivation of MAPK activity during cell wall biogenesis Any process that terminates the activity of the active enzyme MAP kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. BP
GO:0000201 nuclear translocation of MAPK during cell wall biogenesis The directed movement of a MAP kinase to the nucleus during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. BP
GO:0000208 nuclear translocation of MAPK during osmolarity sensing The directed movement of a MAP kinase to the nucleus during osmolarity sensing. BP
GO:0000209 protein polyubiquitination Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain. BP
GO:0004914 interleukin-5 receptor activity Combining with interleukin-5 to initiate a change in cell activity. MF
GO:0004915 interleukin-6 receptor activity Combining with interleukin-6 to initiate a change in cell activity. MF
GO:0004917 interleukin-7 receptor activity Combining with interleukin-7 to initiate a change in cell activity. MF
GO:0004910 interleukin-1, Type II, blocking receptor activity NA MF
GO:0004911 interleukin-2 receptor activity Combining with interleukin-2 to initiate a change in cell activity. MF
GO:0004912 interleukin-3 receptor activity Combining with interleukin-3 to initiate a change in cell activity. MF
GO:0004913 interleukin-4 receptor activity Combining with interleukin-4 to initiate a change in cell activity. MF
GO:0004918 interleukin-8 receptor activity Combining with interleukin-8 to initiate a change in cell activity. MF
GO:0004919 interleukin-9 receptor activity Combining with interleukin-9 to initiate a change in cell activity. MF
GO:0005355 glucose transporter activity Enables the directed movement of the hexose monosaccharide glucose into, out of, within or between cells. MF
GO:0005354 galactose transporter activity Enables the directed movement of galactose into, out of, within or between cells. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. MF
GO:0005357 constitutive hydrogen:glucose transporter activity NA MF
GO:0005356 hydrogen:glucose transporter activity NA MF
GO:0005351 sugar porter activity Catalysis of the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). MF
GO:0005350 pyrimidine transporter activity Enables the directed movement of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells. MF
GO:0005353 fructose transporter activity Enables the directed movement of fructose into, out of, within or between cells. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. MF
GO:0005352 alpha-glucoside:hydrogen symporter activity Catalysis of the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose. MF
GO:0005359 low-affinity hydrogen:glucose transporter activity NA MF
GO:0005358 high-affinity hydrogen:glucose transporter activity NA MF
GO:0051141 negative regulation of NK T cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell proliferation. BP
GO:0051140 regulation of NK T cell proliferation Any process that modulates the frequency, rate or extent of natural killer T cell proliferation. BP
GO:0051143 propanediol metabolic process The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items. BP
GO:0051142 positive regulation of NK T cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell proliferation. BP
GO:0051145 smooth muscle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. BP
GO:0051144 propanediol catabolic process The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH. BP
GO:0051147 regulation of muscle cell differentiation Any process that modulates the frequency, rate or extent of muscle cell differentiation. BP
GO:0051146 striated muscle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. BP
GO:0051149 positive regulation of muscle cell differentiation Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. BP
GO:0051148 negative regulation of muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of muscle cell differentiation. BP
GO:0010061 regulation of trichoblast fate Any process that modulates trichoblast fate specification. BP
GO:0010060 negative regulation of atrichoblast fate Any process that suppresses atrichoblast fate specification. BP
GO:0010063 positive regulation of trichoblast fate Any process that induces or promotes trichoblast fate specification. BP
GO:0010062 negative regulation of trichoblast fate Any process that suppresses trichoblast fate specification. BP
GO:0010065 primary meristem tissue development The process whose specific outcome is the progression of primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium. BP
GO:0010064 embryonic shoot morphogenesis The process by which the anatomical structures of embryonic shoot are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0010067 procambium histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue. BP
GO:0010066 ground meristem histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues. BP
GO:0010069 zygote asymmetric cytokinesis (sensu Magnoliophyta) The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0010068 protoderm histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the epidermis. BP
GO:0018274 peptide cross-linking via L-lysinoalanine The posttranslational modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link. BP
GO:0018275 N-terminal peptidyl-cysteine acetylation The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine. BP
GO:0018276 isopeptide cross-linking via N6-glycyl-L-lysine The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination. BP
GO:0018277 protein amino acid deamination The removal of an amino group from a protein amino acid. BP
GO:0018270 GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine The formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0018271 biotin-protein ligase activity Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein. MF
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine The posttranslation modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine. BP
GO:0018273 protein-chromophore linkage via peptidyl-N6-retinal-L-lysine The posttranslation modification of peptidyl-lysine to form N6-retinal-L-lysine. BP
GO:0018278 N-terminal peptidyl-threonine deamination The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid. BP
GO:0018279 protein amino acid N-linked glycosylation via asparagine The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. BP
GO:0019585 glucuronate metabolic process The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. BP
GO:0019584 galactonate catabolic process The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid. BP
GO:0004008 copper-exporting ATPase activity Catalysis of the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). MF
GO:0019586 galacturonate metabolic process The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. BP
GO:0019580 galactarate metabolic process The chemical reactions and pathways involving galactarate, the anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose. BP
GO:0019583 galactonate metabolic process The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose. BP
GO:0019582 D-galactarate catabolic process The chemical reactions and pathways resulting in the breakdown of D-galactarate, the dextrorotatory isomer of the anion of galactaric acid. BP
GO:0004003 ATP-dependent DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. MF
GO:0004000 adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3. MF
GO:0004001 adenosine kinase activity Catalysis of the reaction: ATP + adenosine = ADP + AMP. MF
GO:0019589 anaerobic glycerol catabolic process to propane-1,3-diol The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water. BP
GO:0019588 anaerobic glycerol catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP. BP
GO:0004004 ATP-dependent RNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix. MF
GO:0007269 neurotransmitter secretion The regulated release of neurotransmitter into the synaptic cleft. BP
GO:0007268 synaptic transmission The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. BP
GO:0007267 cell-cell signaling Any process that mediates the transfer of information from one cell to another. BP
GO:0007266 Rho protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. BP
GO:0007265 Ras protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. BP
GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. BP
GO:0007263 nitric oxide mediated signal transduction A series of molecular signals mediated by the detection of nitric oxide (NO). BP
GO:0007262 STAT protein nuclear translocation The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases. BP
GO:0007261 JAK-induced STAT protein dimerization The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases. BP
GO:0007260 tyrosine phosphorylation of STAT protein The process of introducing a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. BP
GO:0001632 leukotriene B4 receptor activity Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. MF
GO:0001633 secretin-like receptor activity A G-protein coupled receptor that is structurally/functionally related to the secretin receptor. MF
GO:0001630 GP40-like receptor activity NA MF
GO:0001631 cysteinyl leukotriene receptor activity Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide moiety based on cysteine. MF
GO:0001636 corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity NA MF
GO:0001637 G-protein chemoattractant receptor activity NA MF
GO:0018188 peptidyl-proline di-hydroxylation The posttranslational modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline. BP
GO:0018189 pyrroloquinoline quinone biosynthetic process The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed. BP
GO:0018186 peroxidase-heme linkage The covalent linkage of heme to peroxidase. BP
GO:0018187 molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide. BP
GO:0018184 protein amino acid polyamination The modification of a protein amino acid by polyamination. BP
GO:0018185 poly-N-methyl-propylamination The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin. BP
GO:0018182 protein-heme linkage via 3'-L-histidine The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine). BP
GO:0018180 protein amino acid desulfurization The removal of a sulfur group from a protein amino acid. BP
GO:0018181 peptidyl-arginine C5-methylation The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine. BP
GO:0052496 occlusion by host of symbiont xylem The process by which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052497 occlusion by organism of xylem in other organism during symbiotic interaction The process by which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052494 occlusion by host of symbiont vascular system The process by which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0001987 vasoconstriction of artery during baroreceptor response to lowering of blood pressure A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure. BP
GO:0052492 negative regulation by host of symbiont signal transduction pathway Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0001981 baroreceptor detection of arterial stretch The series of events by which the mechanical expansion of an artery is received and converted to a molecular signal. BP
GO:0052490 negative regulation by organism of programmed cell death in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0001983 baroreceptor response to increased blood pressure The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery. BP
GO:0001988 positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure. BP
GO:0001989 increased strength of heart contraction during baroreceptor response to decreased blood pressure Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to decreased blood pressure. BP
GO:0021850 glioblast cell division in the subpallium The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes. BP
GO:0021851 neuroblast division in the dorsal lateral ganglionic eminence The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb. BP
GO:0021852 pyramidal neuron migration The migration of pyramidal neuron precursors from the ventricular zone to the correct layer of the cerebral cortex. BP
GO:0021853 cerebral cortex GABAergic interneuron migration The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. BP
GO:0021854 hypothalamus development The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. BP
GO:0021855 hypothalamus cell migration The directed movement of cells into the hypothalamus region of the forebrain. BP
GO:0021856 hypothalamic tangential migration using cell-axon interactions The movement of hypothalamic neuronal precursors tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons. BP
GO:0021858 GABAergic neuron differentiation in the basal ganglia The process whereby a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron. BP
GO:0021859 pyramidal neuron differentiation The process whereby a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron. BP
GO:0016058 maintenance of rhodopsin mediated signaling Maintenance of the excited state of a photoreceptor cell to produce a steady state current. BP
GO:0016059 deactivation of rhodopsin mediated signaling The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon). BP
GO:0016056 rhodopsin mediated signaling The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon. BP
GO:0016057 changes in polarization state of photoreceptor cell membrane Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. BP
GO:0016054 organic acid catabolic process The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. BP
GO:0016055 Wnt receptor signaling pathway The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell. BP
GO:0016052 carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. BP
GO:0016053 organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. BP
GO:0016050 vesicle organization and biogenesis The assembly and arrangement of any vesicle. BP
GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. BP
GO:0019639 6-hydroxycineole catabolic process The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. BP
GO:0019638 6-hydroxycineole metabolic process The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. BP
GO:0019637 organophosphate metabolic process The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. They include a number of organophosphorus compounds that were originally developed as nerve gases, but were formerly used as insecticides and anthelmintics, which worked by inhibiting serine proteases. BP
GO:0019636 phosphonoacetate metabolic process The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue. BP
GO:0019635 2-aminoethylphosphonate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine. BP
GO:0019634 phosphonate metabolic process The chemical reactions and pathways involving phosphonates, any salt, anion, or ester of phosphonic acid (HPO(OH)2). BP
GO:0019633 shikimate catabolic process The chemical reactions and pathways resulting in the breakdown of shikimate, the anion of shikimic acid. BP
GO:0019632 shikimate metabolic process The chemical reactions and pathways involving shikimate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids. BP
GO:0019631 quinate catabolic process The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid. BP
GO:0019630 quinate metabolic process The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine. BP
GO:0002679 respiratory burst during defense response A phase of elevated metabolic activity, during which oxygen consumption increases made as a defense reponse ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. BP
GO:0048739 cardiac muscle fiber development The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure. BP
GO:0048730 epidermis morphogenesis The process by which the anatomical structures of the epidermis are generated and organized. Morphogenesis pertains to the creation of form. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. BP
GO:0048731 system development The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. BP
GO:0048732 gland development The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. BP
GO:0048733 sebaceous gland development The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure. BP
GO:0048734 proboscis morphogenesis The process by which the anatomical structures of the proboscis are generated and organized. Morphogenesis pertains to the creation of form. The proboscis is the trunk-like extension of the mouthparts on the adult head. BP
GO:0048735 haltere morphogenesis The process by which the anatomical structures of a haltere are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048736 appendage development The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch. BP
GO:0048737 appendage development (sensu Endopterygota) The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0015830 diaminopimelate transport The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of, within or between cells. BP
GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. BP
GO:0015835 peptidoglycan transport Enables the directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of, within or between cells. BP
GO:0015834 peptidoglycan peptide transport The directed movement of peptidoglycan peptides into, out of, within or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. BP
GO:0015837 amine transport The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of, within or between cells. BP
GO:0015836 lipid-linked peptidoglycan transport NA BP
GO:0015839 cadaverine transport The directed movement of cadaverine, 1,5-pentanediamine, into, out of, within or between cells. BP
GO:0015838 betaine transport The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of, within or between cells. BP
GO:0051916 granulocyte colony-stimulating factor binding Interacting selectively with granulocyte colony-stimulating factor, G-CSF. MF
GO:0051917 regulation of fibrinolysis Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. BP
GO:0017093 sterol regulatory element-binding protein protease activity Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding-protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. MF
GO:0051915 induction of synaptic plasticity by chemical substance The process by which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require. BP
GO:0051912 CoB--CoM heterodisulfide reductase activity Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine. MF
GO:0051913 regulation of synaptic plasticity by chemical substance The process by which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require. BP
GO:0051910 heparitin sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparitin = adenosine 3',5'-bisphosphate + N-sulfoheparitin. MF
GO:0051911 Methanosarcina-phenazine hydrogenase activity Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine. MF
GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity NA MF
GO:0017098 sulfonylurea receptor binding Interacting selectively with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel. MF
GO:0051918 negative regulation of fibrinolysis Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. BP
GO:0051919 positive regulation of fibrinolysis Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. BP
GO:0009320 phosphoribosylaminoimidazole carboxylase complex Complex that possesses phosphoribosylaminoimidazole carboxylase activity. CC
GO:0009321 alkyl hydroperoxide reductase complex An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides. CC
GO:0009322 trimethylamine-N-oxide reductase complex An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine. CC
GO:0009323 ribosomal-protein-alanine N-acetyltransferase complex An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine. CC
GO:0009324 D-amino-acid dehydrogenase complex Complex that possesses D-amino-acid dehydrogenase activity. CC
GO:0009325 nitrate reductase complex An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. CC
GO:0009326 formate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2). CC
GO:0009327 NAD(P)+ transhydrogenase complex (AB-specific) NA CC
GO:0009328 phenylalanine-tRNA ligase complex An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe). CC
GO:0009329 acetate CoA-transferase complex A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA. CC
GO:0051063 CDP reductase activity Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin. MF
GO:0051060 pullulanase activity Catalysis of the hydrolysis of (1,6)-a-D-glucosidic linkages in pullulan [a linear polymer of a-(1,6)-linked maltotriose units] and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen. MF
GO:0051061 ADP reductase activity Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin. MF
GO:0047227 indolylacetyl-myo-inositol galactosyltransferase activity Catalysis of the reaction: indole-3-acetyl-myo-inositol + UDP-galactose = 5-O-(indol-3-ylacetyl-myo-inositol)-D-galactoside + UDP. MF
GO:0047226 globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: globotriosylceramide + UDP-N-acetylgalactosamine = globotetraosylceramide + UDP. MF
GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP. MF
GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP. MF
GO:0016878 acid-thiol ligase activity NA MF
GO:0016879 ligase activity, forming carbon-nitrogen bonds Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. MF
GO:0008053 mitochondrial fusion Merging of two or more mitochondria within a cell to form a single compartment. BP
GO:0008052 sensory organ boundary specification The process by which boundaries between a sensory organ and the surrounding tissue are established and maintained. BP
GO:0008055 ocellus pigment biosynthetic process The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. BP
GO:0008054 cyclin catabolic process The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions. BP
GO:0008057 eye pigment granule organization and biogenesis The assembly and arrangement of intracellular pigment storage granules in the eye. The majority of pigment granules are found in the pigment cells. Smaller numbers are found in other cell types including the photoreceptor cell. BP
GO:0008056 ocellus development The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects. BP
GO:0008058 ocellus pigment granule organization and biogenesis The assembly and arrangement of intracellular pigment storage granules in the ocellus. BP
GO:0016872 intramolecular lyase activity The catalysis of certain rearrangements of a molecule to break or form a ring. MF
GO:0016874 ligase activity Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. MF
GO:0016875 ligase activity, forming carbon-oxygen bonds Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. MF
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds NA MF
GO:0016877 ligase activity, forming carbon-sulfur bonds Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. MF
GO:0015270 dihydropyridine-sensitive calcium channel activity NA MF
GO:0008589 regulation of smoothened signaling pathway Any process that modulates the frequency, rate or extent of smoothened signaling. BP
GO:0008588 release of cytoplasmic sequestered NF-kappaB The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus. BP
GO:0008583 mystery cell fate differentiation (sensu Endopterygota) The process by which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0008582 regulation of synaptic growth at neuromuscular junction Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions. BP
GO:0008581 ubiquitin-specific protease 5 activity Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin. MF
GO:0008587 wing margin morphogenesis The process by which the anatomical structures of the wing margin are generated and organized. Morphogenesis pertains to the creation of form. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade. BP
GO:0008586 wing vein morphogenesis NA BP
GO:0008585 female gonad development The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. BP
GO:0008584 male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. BP
GO:0045309 protein phosphorylated amino acid binding Interacting selectively with a phosphorylated amino acid residue within a protein. MF
GO:0045304 regulation of establishment of competence for transformation Any process that modulates the frequency, rate or extent of the process by which a cell becomes able to take up and incorporate extracellular DNA into its genome. BP
GO:0045302 choloylglycine hydrolase activity Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine. MF
GO:0045303 diaminobutyrate-2-oxoglutarate transaminase activity Catalysis of the reaction: L-2,4-diaminobutyrate + 2-oxoglutarate = L-glutamate + L-aspartic 4-semialdehyde. MF
GO:0045300 acyl-[acyl-carrier-protein] desaturase activity Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. MF
GO:0045301 tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin. MF
GO:0010172 embryonic body morphogenesis The process by which the anatomical structures of the embryonic soma are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0010171 body morphogenesis The process by which the anatomical structures of the soma are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0047230 flavonol-3-O-glucoside L-rhamnosyltransferase activity Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP. MF
GO:0047231 pyridoxine 5'-O-beta-D-glucosyltransferase activity Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + UDP. MF
GO:0047232 galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP. MF
GO:0047233 N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. MF
GO:0047234 raffinose-raffinose alpha-galactotransferase activity Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose. MF
GO:0047235 sucrose 6F-alpha-galactotransferase activity Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP. MF
GO:0047236 methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity Catalysis of the reaction: CH(3)-N(O)=N-CH(2)OH + UDP-D-glucose = cycasin + UDP. MF
GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP. MF
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. MF
GO:0047239 hydroxymandelonitrile glucosyltransferase activity Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = taxiphyllin + UDP. MF
GO:0015068 glycine amidinotransferase activity Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. MF
GO:0015069 scyllo-inosamine-4-phosphate amidinotransferase activity Catalysis of the reaction: L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate. MF
GO:0046541 saliva secretion The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. BP
GO:0046540 U4/U6 x U5 tri-snRNP complex A complex composed of three small nuclear ribonucleoproteins, snRNP U4, snRNP U6 and snRNP U5. CC
GO:0046543 development of secondary female sexual characteristics The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion. BP
GO:0046545 development of primary female sexual characteristics The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. BP
GO:0046544 development of secondary male sexual characteristics The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion. BP
GO:0046547 trans-aconitate 3-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate. MF
GO:0046546 development of primary male sexual characteristics The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion. BP
GO:0046549 retinal cone cell development Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. BP
GO:0046548 retinal rod cell development Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. BP
GO:0010177 methylthioalkylmalate synthase activity Catalysis of the reaction: w-methylthio-2-oxoalkanoic acid + acetyl-CoA + H2O = 2-(w-methylthio)alkylmalate + CoA. MF
GO:0035228 negative regulation of glutamate-cysteine ligase activity Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase. BP
GO:0035229 positive regulation of glutamate-cysteine ligase activity Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate. BP
GO:0035226 glutamate-cysteine ligase catalytic subunit binding Interacting selectively with the catalytic subunit of glutamate-cysteine ligase. MF
GO:0035227 regulation of glutamate-cysteine ligase activity Any process that modulates the activity of glutamate-cysteine ligase. BP
GO:0035224 genital disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium). BP
GO:0035225 determination of genital disc primordium Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two. BP
GO:0035222 wing disc pattern formation The process giving rise to the pattern of cell differentiation in the wing imaginal disc. BP
GO:0035223 leg disc pattern formation The process that gives rise to the patterns of cell differentiation in the leg imaginal disc. BP
GO:0035220 wing disc development Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura. BP
GO:0035221 genital disc pattern formation The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc. BP
GO:0047498 calcium-dependent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; requires Ca2+. MF
GO:0047499 calcium-independent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; does not require Ca2+. MF
GO:0047494 serine-phosphoethanolamine synthase activity Catalysis of the reaction: CDP-ethanolamine + L-serine = CMP + L-serine-phosphoethanolamine. MF
GO:0047495 membrane-oligosaccharide glycerophosphotransferase activity Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another. MF
GO:0047496 vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. BP
GO:0047497 mitochondrion transport along microtubule The directed movement of a mitochondrion along a microtubule, mediated by motor proteins. BP
GO:0047490 pectin lyase activity Catalysis of the eliminative cleavage of (14)-a-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-a-D-galact-4-enuronosyl groups at their nonreducing ends. MF
GO:0047491 poly(alpha-L-guluronate) lyase activity Catalysis of the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends. MF
GO:0047492 xanthan lyase activity Catalysis of the eliminative cleavage of the terminal b-D-mannosyl-b-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-a-L-threo-hex-4-enuronosyl group at the terminus of the side-chain. MF
GO:0047493 ceramide cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + N-acylsphingosine = CMP + sphingomyelin. MF
GO:0045896 regulation of transcription, mitotic A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis. BP
GO:0045897 positive regulation of transcription, mitotic Any process that activates or increases the frequency, rate or extent of transcription during mitosis. BP
GO:0045894 negative regulation of transcription, mating-type specific Any mating-type specific process that stops, prevents or reduces the rate of transcription. BP
GO:0045895 positive regulation of transcription, mating-type specific Any mating-type specific process that activates or increases the rate of transcription. BP
GO:0045892 negative regulation of transcription, DNA-dependent Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription. BP
GO:0045893 positive regulation of transcription, DNA-dependent Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription. BP
GO:0045898 regulation of transcriptional preinitiation complex formation Any process that modulates the frequency, rate or extent of transcriptional preinitiation complex formation. BP
GO:0045899 positive regulation of transcriptional preinitiation complex formation Any process that activates or increases the frequency, rate or extent of transcriptional preinitiation complex formation. BP
GO:0043076 megasporocyte nucleus The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents. CC
GO:0043077 initiation of acetate catabolic process The activation of the chemical reactions and pathways resulting in the breakdown of acetate. BP
GO:0043072 negative regulation of non-apoptotic programmed cell death Any process that stops, prevents or reduces the frequency, rate or extent of non-apoptotic programmed cell death, cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis. BP
GO:0043073 germ cell nucleus The nucleus of a germ cell, a cell specialized to produce haploid gametes, and its descendents. CC
GO:0043070 regulation of non-apoptotic programmed cell death Any process that modulates the frequency, rate or extent of non-apoptotic programmed cell death, cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis. BP
GO:0043071 positive regulation of non-apoptotic programmed cell death Any process that activates or increases the frequency, rate or extent of non-apoptotic programmed cell death, cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis. BP
GO:0043078 polar nucleus Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus. CC
GO:0043079 antipodal cell nucleus The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents. CC
GO:0031213 RSF complex A chromatin remodeling complex that mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In humans, the complex is composed of the ATPase hSNF2H and the HBXAP protein (RSF-1). CC
GO:0042676 cone cell fate commitment The process by which a cell becomes committed to become a cone cell. BP
GO:0031211 palmitoyltransferase complex A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue. CC
GO:0031210 phosphatidylcholine binding Interacting selectively with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. MF
GO:0031217 glucan 1,4-beta-glucosidase activity Catalysis of the hydrolysis of 1,4-linkages in 1,4-beta-D-glucans, to remove successive glucose units. MF
GO:0031216 neopullulanase activity Catalysis of the hydrolysis of pullulan to panose (6-a-D-glucosylmaltose). MF
GO:0031215 shell calcification The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell. BP
GO:0031214 biomineral formation Formation of hard tissues that consist mainly of norganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. BP
GO:0031219 levanase activity Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units. MF
GO:0031218 arabinogalactan endo-1,4-beta-galactosidase activity Catalysis of the endohydrolysis of 1,4-beta-D-galactosidic linkages in arabinogalactans. MF
GO:0042679 cone cell fate specification Process by which a cell becomes capable of differentiating autonomously into a cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0042678 cone cell fate specification (sensu Endopterygota) Process by which a cell becomes capable of differentiating autonomously into an cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048329 negative regulation of axial mesodermal cell fate specification Any process that stops, prevents or reduces the frequency, rate or extent of axial mesoderm cell fate specification. BP
GO:0048328 regulation of axial mesodermal cell fate specification Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification. BP
GO:0048323 axial mesodermal cell fate determination Process by which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0048322 axial mesodermal cell fate commitment The process by which a cell becomes committed to become an axial mesoderm cell. BP
GO:0048321 axial mesodermal cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an axial mesoderm cell. BP
GO:0048320 axial mesoderm formation The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. BP
GO:0048327 axial mesodermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0048326 positive regulation of axial mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination. BP
GO:0048325 negative regulation of axial mesodermal cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of axial mesoderm cell fate determination. BP
GO:0048324 regulation of axial mesodermal cell fate determination Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination. BP
GO:0009049 aspartic-type signal peptidase activity Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism. MF
GO:0009048 dosage compensation, by inactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. BP
GO:0050579 vellosimine dehydrogenase activity Catalysis of the reaction: 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+. MF
GO:0050578 (R)-2-hydroxyacid dehydrogenase activity Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+. MF
GO:0050573 dTDP-4-dehydro-6-deoxyglucose reductase activity Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+. MF
GO:0009040 ureidoglycolate dehydrogenase activity Catalysis of the reaction: (S)-ureidoglycolate + NADP+ = oxalureate + NADPH + H+. MF
GO:0050571 1,5-anhydro-D-fructose reductase activity Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+. MF
GO:0050570 4-hydroxythreonine-4-phosphate dehydrogenase activity Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+. MF
GO:0009045 xylose isomerase activity Catalysis of the reaction: D-xylose = D-xylulose. MF
GO:0050576 3-keto-steroid reductase activity Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH + H+. MF
GO:0009047 dosage compensation, by hyperactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. BP
GO:0009046 zinc D-Ala-D-Ala carboxypeptidase activity Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine. MF
GO:0019038 provirus The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle. CC
GO:0019035 viral integration complex Virus-specific complex of protein required for integrating viral genomes into the host genome. CC
GO:0019034 viral replication complex Specific locations and structures in the virus infected cell involved in replicating the viral genome. CC
GO:0019037 viral assembly intermediate Specific locations and structures in the virus infected cell involved in assembling new virions. CC
GO:0019036 viral transcriptional complex Specific locations and structures in the virus infected cell involved in transcribing the viral genome. CC
GO:0019031 viral envelope The lipid bilayer and associated glycoproteins that surround many types of virus particle. CC
GO:0019030 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Tobacco satellite necrosis virus has such a capsid structure. CC
GO:0019033 viral tegument A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically. CC
GO:0032173 septin collar A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell. CC
GO:0032172 germ tube septin ring A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins. CC
GO:0032171 germ tube septin cap A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. CC
GO:0032170 pseudohyphal septin ring A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins. CC
GO:0032177 bud neck split septin rings Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated. CC
GO:0032176 split septin rings A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well. CC
GO:0032175 mating projection septin ring A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip. CC
GO:0032174 bud neck septin collar A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck. CC
GO:0032179 germ tube The slender tubular outgrowth first produced by most spores in germination. CC
GO:0032178 medial membrane band A sterol rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum. CC
GO:0005962 isocitrate dehydrogenase complex (NAD+) (sensu Eukaryota) Complex that possesses isocitrate dehydrogenase (NAD+) activity. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0005963 magnesium-dependent protein serine/threonine phosphatase complex An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase. CC
GO:0005960 glycine cleavage complex A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase. CC
GO:0005961 glycine dehydrogenase complex (decarboxylating) A component, along with aminomethyltransferase, of the glycine cleavage system; it is found as a homodimer or as a tetramer with two alpha subunits and two beta subunits. CC
GO:0005966 photoreceptor cyclic-nucleotide phosphodiesterase complex An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide. CC
GO:0005967 pyruvate dehydrogenase complex (sensu Eukaryota) Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. CC
GO:0005965 protein farnesyltransferase complex A complex that possesses protein farnesyltransferase activity. CC
GO:0005968 Rab-protein geranylgeranyltransferase complex A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl moiety from geranylgeranyl pyrophosphate to a Rab protein. CC
GO:0005969 serine-pyruvate aminotransferase, type 2B complex An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate. CC
GO:0006703 estrogen biosynthetic process The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. BP
GO:0006702 androgen biosynthetic process The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. BP
GO:0006701 progesterone biosynthetic process The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. BP
GO:0006700 C21-steroid hormone biosynthetic process The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. BP
GO:0006707 cholesterol catabolic process The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. BP
GO:0006706 steroid catabolic process The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. BP
GO:0006705 mineralocorticoid biosynthetic process The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. BP
GO:0006704 glucocorticoid biosynthetic process The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. BP
GO:0006709 progesterone catabolic process The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. BP
GO:0006708 ecdysone catabolic process The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. BP
GO:0043063 intercellular bridge organization and biogenesis The assembly and arrangement of the intracellular bridge. BP
GO:0046689 response to mercury ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. BP
GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. CC
GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. MF
GO:0000017 alpha-glucoside transport The directed movement of alpha-glucosides into, out of, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. BP
GO:0000016 lactase activity Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. MF
GO:0000011 vacuole inheritance The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. BP
GO:0000010 trans-hexaprenyltranstransferase activity Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate. MF
GO:0000012 single strand break repair The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. BP
GO:0046682 response to cyclodiene A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring. BP
GO:0000019 regulation of mitotic recombination Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. BP
GO:0000018 regulation of DNA recombination Any process that modulates the frequency, rate or extent of DNA recombination, the processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. BP
GO:0046683 response to organophosphorus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. BP
GO:0004705 JUN kinase activity Catalysis of the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. MF
GO:0004704 NF-kappaB-inducing kinase activity NA MF
GO:0004707 MAP kinase activity Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. MF
GO:0004706 JUN kinase kinase kinase activity Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs). MF
GO:0004701 diacylglycerol-activated phospholipid-dependent protein kinase C activity NA MF
GO:0004700 atypical protein kinase C activity NA MF
GO:0004703 G-protein coupled receptor kinase activity Catalysis of the phosphorylation of a G-protein coupled receptor, thereby modulating its activity. MF
GO:0004702 receptor signaling protein serine/threonine kinase activity NA MF
GO:0004709 MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. MF
GO:0004708 MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase. MF
GO:0018025 calmodulin-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. MF
GO:0018024 histone-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. MF
GO:0018027 peptidyl-lysine di-methylation The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. BP
GO:0018026 peptidyl-lysine mono-methylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. BP
GO:0018021 peptidyl-histidine methylation The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). BP
GO:0018020 peptidyl-glutamic acid methylation NA BP
GO:0018023 peptidyl-lysine tri-methylation The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. BP
GO:0018022 peptidyl-lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or tri-methylated derivative. BP
GO:0018029 peptidyl-lysine palmitoylation The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine. BP
GO:0018028 peptidyl-lysine myristoylation The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine. BP
GO:0051336 regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. BP
GO:0051337 amitosis Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation. BP
GO:0051334 meiosis I nuclear envelope reassembly The reformation of the nuclear envelope during meiosis I. BP
GO:0051335 meiosis II nuclear envelope reassembly The reformation of the nuclear envelope during meiosis II. BP
GO:0051332 S phase of meiotic cell cycle Progression through S phase, the part of the meiotic cell cycle during which DNA synthesis takes place. BP
GO:0051333 meiotic nuclear envelope reassembly The cell cycle process whereby the reformation of the nuclear envelope during meiosis occurs. BP
GO:0051330 G1 phase of meiotic cell cycle Progression through G1 phase, one of two 'gap' phases in the meiotic cell cycle; G1 is the interval between the completion of meiosis and the beginning of DNA synthesis. BP
GO:0051331 G2 phase of meiotic cell cycle Progression through G2 phase, one of two 'gap' phases in the meiotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of meiosis. BP
GO:0007542 primary sex determination, germ-line The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line. BP
GO:0007543 sex determination, somatic-gonadal interaction The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism. BP
GO:0007540 sex determination, establishment of X:A ratio The developmental process by which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it. BP
GO:0007541 sex determination, primary response to X:A ratio The developmental process by which an organism interprets its X to autosomal chromosomal complement. BP
GO:0007546 somatic processes downstream of sex determination signal The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways. BP
GO:0007547 germ-line processes downstream of sex determination signal The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways. BP
GO:0051338 regulation of transferase activity Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. BP
GO:0051339 regulation of lyase activity Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. BP
GO:0015264 methylammonium channel activity NA MF
GO:0015265 urea channel activity NA MF
GO:0015266 protein channel activity NA MF
GO:0015267 channel or pore class transporter activity Allows facilitated diffusion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without a carrier-mediated mechanism. They do not exhibit stereospecificity but may be specific for a particular molecular species or class of molecules. MF
GO:0015260 isethionate channel activity NA MF
GO:0015261 lactate channel activity NA MF
GO:0015262 taurine channel activity NA MF
GO:0015268 alpha-type channel activity Allows the movement of solutes by energy-independent process by passage through a transmembrane aqueous pore. Usually consist of alpha-helical membrane spanners, although beta-strands may be present and contribute to channel. MF
GO:0015269 calcium-activated potassium channel activity NA MF
GO:0016795 phosphoric triester hydrolase activity Catalysis of the hydrolysis of a phosphoric triester. MF
GO:0016794 diphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group. MF
GO:0016797 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. MF
GO:0019779 APG8 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0016791 phosphoric monoester hydrolase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. MF
GO:0016790 thiolester hydrolase activity Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. MF
GO:0016793 triphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. MF
GO:0019772 low affinity IgG receptor activity Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity. MF
GO:0019773 proteasome core complex, alpha-subunit complex (sensu Eukaryota) Refers to the subunits that constitute the outer rings of the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0019770 IgG receptor activity Combining with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity. MF
GO:0019771 high affinity IgG receptor activity Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity. MF
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds NA MF
GO:0016798 hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond. MF
GO:0019774 proteasome core complex, beta-subunit complex (sensu Eukaryota) Refers to the subunits that constitute the inner rings of the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0019775 FAT10 conjugating enzyme activity Catalysis of the covalent attachment of the ubiquitin-like protein FAT10 to other proteins. MF
GO:0001863 collectin receptor activity Combining with a collectin to initiate a change in cell activity. MF
GO:0001862 collectin binding Interacting selectively with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus. MF
GO:0001861 complement component C4b receptor activity Combining with the C4b product of the classical complement cascade to initiate a change in cell activity. MF
GO:0001860 complement component C3d receptor activity Combining with the C3d product of the complement cascade to initiate a change in cell activity. MF
GO:0001867 complement activation, lectin pathway Processes involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. BP
GO:0001866 NK T cell proliferation The expansion of a NK T cell population by cell division. BP
GO:0001865 NK T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a NK T cell. BP
GO:0001864 pentraxin binding Interacting selectively with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array. MF
GO:0001869 negative regulation of complement activation, lectin pathway Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway. BP
GO:0001868 regulation of complement activation, lectin pathway Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation. BP
GO:0030320 monovalent inorganic anion homeostasis The regulation of the levels, transport, and metabolism of monovalent inorganic anions within a cell or between a cell and its external environment. BP
GO:0030321 transepithelial chloride transport The directed movement of chloride ions across an epithelium. BP
GO:0030322 stabilization of membrane potential The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. BP
GO:0030323 respiratory tube development The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. BP
GO:0030324 lung development The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the oesophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. BP
GO:0030325 adrenal gland development The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. BP
GO:0030326 embryonic limb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. BP
GO:0030327 prenylated protein catabolic process The chemical reactions and pathways resulting in the breakdown of prenylated proteins. BP
GO:0030328 prenylcysteine catabolic process The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. BP
GO:0030329 prenylcysteine metabolic process The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. BP
GO:0016249 channel localizer activity Functions to locate the position of ion channels in the cell. MF
GO:0016248 channel inhibitor activity NA MF
GO:0016247 channel regulator activity NA MF
GO:0016246 RNA interference The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes. BP
GO:0016245 hyperphosphorylation of RNA polymerase II The production of an RNA polymerase II enzyme where the C-Terminal Domain (CTD) of the largest subunit is extensively phosphorylated, as a result of activation of kinases, deactivation of phosphatases, or both. This phosphorylation occurs during the initiation phase and is required for the transition to the elongation phase. Specific types of phosphorylation within the CTD are associated with recruitment of complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. BP
GO:0016244 non-apoptotic programmed cell death Cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis. BP
GO:0016243 regulation of autophagic vacuole size Any process that modulates the size of the autophagic vacuole. BP
GO:0016242 negative regulation of macroautophagy Any process that stops, prevents or reduces the frequency, rate or extent of macroautophagy. BP
GO:0016241 regulation of macroautophagy Any process that modulates the frequency, rate or extent of macroautophagy. BP
GO:0016240 autophagic vacuole docking NA BP
GO:0017118 lipoyltransferase activity Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme. MF
GO:0017119 Golgi transport complex A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). CC
GO:0017114 wide-spectrum protease inhibitor activity NA MF
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. MF
GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex NA CC
GO:0017110 nucleoside-diphosphatase activity Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. MF
GO:0017111 nucleoside-triphosphatase activity Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. MF
GO:0017112 Rab guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+. MF
GO:0018316 peptide cross-linking via L-cystine The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain. BP
GO:0047807 cytokinin 7-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + N6-alkylaminopurine = UDP + N6-alkylaminopurine-7-beta-D-glucoside. MF
GO:0047806 cytochrome-c3 hydrogenase activity Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3. MF
GO:0047805 cytidylate cyclase activity Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate. MF
GO:0047804 cysteine-S-conjugate beta-lyase activity Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. MF
GO:0047803 cysteine lyase activity Catalysis of the reaction: L-cysteine + SO3(2-) (sulfite) = L-cysteate + sulfide. MF
GO:0047802 cysteine-conjugate transaminase activity Catalysis of the reaction: S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = S-(4-bromophenyl)-mercaptopyruvate + L-glutamate. MF
GO:0047801 cysteine transaminase activity Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate. MF
GO:0047800 cysteamine dioxygenase activity Catalysis of the reaction: cysteamine + O2 = hypotaurine. MF
GO:0031059 histone deacetylation at centromere The removal of acetyl groups from histones in centromeric DNA. BP
GO:0031058 positive regulation of histone modification Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone. BP
GO:0047809 D-2-hydroxy-acid dehydrogenase activity Catalysis of the reaction: (R)-lactate + acceptor = pyruvate + reduced acceptor. MF
GO:0047808 D(-)-tartrate dehydratase activity Catalysis of the reaction: (S,S)-tartrate = oxaloacetate + H2O. MF
GO:0031589 cell-substrate adhesion The attachment of a cell to the underlying substrate via adhesion molecules. BP
GO:0031588 AMP-activated protein kinase complex A protein complex that possesses AMP-dependent protein kinase activity. CC
GO:0031583 G-protein signaling, phospholipase D activating pathway A G-protein coupled signaling pathway that results in the activation of phospholipase D, causing an increase in cellular levels of phosphatidic acid. BP
GO:0031582 replication fork blocking at rDNA repeats A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer. BP
GO:0031581 hemidesmosome assembly Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. BP
GO:0031580 lipid raft distribution The processes that establish the spatial arrangement of lipid rafts within the plasma membrane. BP
GO:0031587 positive regulation of IP3 receptor activity Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor. BP
GO:0031586 negative regulation of IP3 receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor. BP
GO:0031585 regulation of IP3 receptor activity Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor. BP
GO:0031584 phospholipase D activation The series of molecular signals that results in the upregulation of phospholipase D activity in response to the initial signal. BP
GO:0009289 fimbrium A proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter. CC
GO:0009288 flagellum (sensu Bacteria) A 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009283 cytosolic small ribosomal subunit (sensu Bacteria) The small subunit of a ribosome; has a sedimentation coefficient of 30S. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009282 cytosolic large ribosomal subunit (sensu Bacteria) The large subunit of a ribosome; has a sedimentation coefficient of 50S. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009281 cytosolic ribosome (sensu Bacteria) The cytosolic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0022604 regulation of cell morphogenesis Any process that modulates the frequency, rate or extent of cell morphogenesis. BP
GO:0022605 oogenesis stage A process that contributes to the formation and maturation of an ovum or female gamete from a primordial female germ cell. BP
GO:0022606 establishment of proximal/distal cell polarity The specification and formation of the polarity of a cell along its proximal/distal axis. BP
GO:0022607 cellular structure assembly A cellular process that results in the assembly of a part of the cell. BP
GO:0022600 digestive process A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. BP
GO:0022601 menstrual cycle phase The progression of physiological phases, occurring in the endometrium, that recur at regular intervals during the reproductive years. BP
GO:0022602 menstrual cycle process A process involved in the sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. BP
GO:0022603 regulation of anatomical structure morphogenesis NA BP
GO:0022608 multicellular organism adhesion The attachment of a multicellular organism to a substrate or other organism. BP
GO:0022609 multicellular organism adhesion to substrate The attachment of a multicellular organism to a surface or material. BP
GO:0032771 regulation of monophenol oxygenase activity Any process that modulates the activity of the enzyme monophenol oxygenase. BP
GO:0032770 positive regulation of monooxygenase activity Any process that activates or increases the activity of a monooxygenase. BP
GO:0032773 positive regulation of monophenol oxygenase activity Any process that activates or increases the activity of the enzyme monophenol oxygenase. BP
GO:0032772 negative regulation of monophenol oxygenase activity Any process that stops or reduces the activity of the enzyme monophenol oxygenase. BP
GO:0032775 DNA methylation on adenine The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule. BP
GO:0032774 RNA biosynthetic process The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. BP
GO:0032777 Piccolo NuA4 histone acetyltransferase complex A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. CC
GO:0032776 DNA methylation on cytosine The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule. BP
GO:0032779 copper-induced intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell, induced by an increase in copper ion concentration. BP
GO:0032778 cobalt-transporting ATPase activity Catalysis of the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in). MF
GO:0008626 induction of apoptosis by granzyme NA BP
GO:0043617 cellular response to sucrose starvation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose. BP
GO:0008624 induction of apoptosis by extracellular signals Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis. BP
GO:0008625 induction of apoptosis via death domain receptors NA BP
GO:0008622 epsilon DNA polymerase complex A nuclear DNA polymerase with proofreading exonuclease activity. High processivity in the absence of PCNA. Also involved in nucleotide-excision repair and mismatch repair. CC
GO:0008623 chromatin accessibility complex A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. CC
GO:0043610 regulation of carbohydrate utilization Any process that modulates the frequency, rate or extent of carbohydrate utilization. BP
GO:0043611 isoprene metabolic process The chemical reactions and pathways involving isoprene, C5H8. BP
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). BP
GO:0008629 induction of apoptosis by intracellular signals Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis. BP
GO:0045519 interleukin-23 receptor binding Interacting selectively with the interleukin-23 receptor. MF
GO:0045518 interleukin-22 receptor binding Interacting selectively with the interleukin-22 receptor. MF
GO:0045517 interleukin-20 receptor binding Interacting selectively with the interleukin-20 receptor. MF
GO:0045516 interleukin-19 receptor binding Interacting selectively with the interleukin-19 receptor. MF
GO:0045515 interleukin-18 receptor binding Interacting selectively with the interleukin-18 receptor. MF
GO:0045514 interleukin-16 receptor binding Interacting selectively with the interleukin-16 receptor. MF
GO:0045513 interleukin-27 binding Interacting selectively with interleukin-27. MF
GO:0045512 interleukin-26 binding Interacting selectively with interleukin-26. MF
GO:0045511 interleukin-25 binding Interacting selectively with interleukin-25. MF
GO:0045510 interleukin-24 binding Interacting selectively with interleukin-24. MF
GO:0042056 chemoattractant activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. MF
GO:0042054 histone methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a histone. MF
GO:0042053 regulation of dopamine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. BP
GO:0042052 rhabdomere development The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. BP
GO:0042051 eye photoreceptor development (sensu Endopterygota) The process whose specific outcome is the progression of a light-responsive receptor in the eye over time, from its formation to the mature structure. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. BP
GO:0042058 regulation of epidermal growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. BP
GO:0050689 negative regulation of antiviral response by host Host processes that result in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0050688 regulation of antiviral response Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. BP
GO:0050685 positive regulation of mRNA processing Any process that activates or increases the frequency, rate or extent of mRNA processing. BP
GO:0050684 regulation of mRNA processing Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. BP
GO:0050687 negative regulation of antiviral response Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. BP
GO:0050686 negative regulation of mRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of mRNA processing. BP
GO:0050681 androgen receptor binding Interacting selectively with an androgen receptor. MF
GO:0050680 negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. BP
GO:0050683 AF-1 domain binding Interacting selectively with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. MF
GO:0050682 AF-2 domain binding Interacting selectively with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. MF
GO:0046736 active induction of humoral immune response in host by virus The intentional, virally-encoded stimulation of a host humoral defense response to viral infection. BP
GO:0046737 active induction of cell-mediated immune response in host by virus The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection. BP
GO:0046734 passive induction of cell-mediated immune response in host by virus The unintentional stimulation by a virus of a cell-mediated host defense response to viral infection, as part of the viral infectious cycle. BP
GO:0046735 passive induction of innate immune response in host by virus The unintentional stimulation by a virus of an innate host defense response to viral infection, as part of the viral infectious cycle. BP
GO:0046732 active induction of host immune response by virus The intentional, virally-encoded stimulation of a host defense response to viral infection. BP
GO:0046733 passive induction of humoral immune response in host by virus The unintentional stimulation by a virus of a host humoral defense response to viral infection, as part of the viral infectious cycle. BP
GO:0046730 induction of host immune response by virus The induction by a virus of an immune response in the host organism. BP
GO:0046731 passive induction of host immune response by virus The unintentional stimulation by a virus of a host defense response to viral infection, as part of the viral infectious cycle. BP
GO:0050504 mannosyl-3-phosphoglycerate synthase activity Catalysis of the reaction: GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate. MF
GO:0046738 active induction of innate immune response in host by virus The intentional, virally-encoded stimulation of an innate host defense response to viral infection. BP
GO:0046739 spread of virus within host The dissemination of infectious virion particles within an infected host organism. BP
GO:0002664 regulation of T cell tolerance induction Any process that modulates the frequency, rate, or extent of T cell tolerance induction. BP
GO:0002665 negative regulation of T cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction. BP
GO:0002666 positive regulation of T cell tolerance induction Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction. BP
GO:0002667 regulation of T cell anergy Any process that modulates the frequency, rate, or extent of T cell anergy. BP
GO:0002660 positive regulation of peripheral tolerance induction Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction. BP
GO:0002661 regulation of B cell tolerance induction Any process that modulates the frequency, rate, or extent of B cell tolerance induction. BP
GO:0002662 negative regulation of B cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction. BP
GO:0002663 positive regulation of B cell tolerance induction Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction. BP
GO:0009070 serine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. BP
GO:0002668 negative regulation of T cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy. BP
GO:0002669 positive regulation of T cell anergy Any process that activates or increases the frequency, rate, or extent of T cell anergy. BP
GO:0009071 serine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. BP
GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). BP
GO:0050501 hyaluronan synthase activity Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)](n) + 2n UDP. MF
GO:0030049 muscle filament sliding The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. BP
GO:0030048 actin filament-based movement Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. BP
GO:0030041 actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament. BP
GO:0030043 actin filament fragmentation The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins. BP
GO:0030042 actin filament depolymerization Disassembly of actin filaments by the removal of actin monomers from a filament. BP
GO:0030047 actin modification Covalent modification of an actin molecule. BP
GO:0030046 parallel actin filament bundle formation Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. BP
GO:0048486 parasympathetic nervous system development The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. BP
GO:0048487 beta-tubulin binding Interacting selectively with the microtubule constituent protein beta-tubulin. MF
GO:0048484 enteric nervous system development The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. BP
GO:0048485 sympathetic nervous system development The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. BP
GO:0048482 ovule morphogenesis The process by which the anatomical structures of the ovule are generated and organized. Morphogenesis pertains to the creation of form. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. BP
GO:0048483 autonomic nervous system development The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. BP
GO:0048480 stigma development The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky. BP
GO:0048481 ovule development The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. BP
GO:0048488 synaptic vesicle endocytosis Invagination of the axonal plasma membrane creating a membrane bound vesicle. Without this process the presynaptic terminal would swell up due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage/release. BP
GO:0048489 synaptic vesicle transport The directed movement of substances in synaptic membrane-bound vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body. BP
GO:0004549 tRNA-specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. MF
GO:0004540 ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. MF
GO:0048158 oogonium stage, oogenesis (sensu Mammalia) The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048159 primary oocyte stage, oogenesis The stage in mammalian oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells. BP
GO:0005736 DNA-directed RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. CC
GO:0048150 behavioral response to ether A change in the behavior of an organism as a result of an ether stimulus. BP
GO:0048151 hyperphosphorylation The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both. BP
GO:0048152 S100 beta biosynthetic process The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. BP
GO:0048153 S100 alpha biosynthetic process The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. BP
GO:0048154 S100 beta binding Interacting selectively with S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. MF
GO:0048155 S100 alpha binding Interacting selectively with S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. MF
GO:0048156 tau protein binding Interacting selectively with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. MF
GO:0048157 oogenesis (sensu Mammalia) The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0005732 small nucleolar ribonucleoprotein complex A complex composed of RNA of the small nucleolar RNA (snoRNA) and protein, found in the nucleolus of a eukaryotic cell. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. CC
GO:0042732 D-xylose metabolic process The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. BP
GO:0042733 embryonic digit morphogenesis The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. Morphogenesis pertains to the creation of form. A digit is one of the terminal divisions of an appendage. For example a finger or toe. BP
GO:0042730 fibrinolysis An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots. BP
GO:0042731 PH domain binding Interacting selectively with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. MF
GO:0042736 NADH kinase activity Catalysis of the reaction: ATP + NADH = ADP + NADPH. MF
GO:0005731 nucleolus organizer complex NA CC
GO:0042734 presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. CC
GO:0042735 protein body Membrane-bound plant organelle found in the developing endosperm, contains storage proteins. CC
GO:0042738 exogenous drug catabolic process The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. BP
GO:0005730 nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. CC
GO:0042884 microcin transport The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of, within or between cells. BP
GO:0042885 microcin B17 transport The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of, within or between cells. BP
GO:0042886 amide transport The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of, within or between cells. BP
GO:0042887 amide transporter activity Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of, within or between cells. MF
GO:0042880 D-glucuronate transporter activity Enables the directed movement of D-glucuronate, the dextrorotatory isomer of glucuronate, into, out of, within or between cells. MF
GO:0042881 D-galactonate transporter activity Enables the directed movement of D-galactonate, the dextrorotatory isomer of galactonate, into, out of, within or between cells. MF
GO:0042882 L-arabinose transport The directed movement of L-arabinose, the levorotatory isomer of arabinose, into, out of, within or between cells. BP
GO:0042883 cysteine transport The directed movement of cysteine into, out of, within or between cells. BP
GO:0042888 molybdenum ion transporter activity Enables the directed movement of molybdenum (Mo) ions into, out of, within or between cells. MF
GO:0042889 3-phenylpropionic acid transport The directed movement of 3-phenylpropionic acid into, out of, within or between cells. BP
GO:0050308 sugar-phosphatase activity Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. MF
GO:0050309 sugar-terminal-phosphatase activity Catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate. MF
GO:0050300 streptomycin 6-kinase activity Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 6-phosphate. MF
GO:0050301 streptomycin-6-phosphatase activity Catalysis of the reaction: streptomycin 6-phosphate + H2O = streptomycin + phosphate. MF
GO:0050302 indole-3-acetaldehyde oxidase activity Catalysis of the reaction: O2 + 2 indole acetaldehyde = 2 indole-3-acetic acid (IAA). MF
GO:0050303 lysine 6-dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine. MF
GO:0050304 nitrous-oxide reductase activity Catalysis of the reaction: nitrogen + H2O + acceptor = nitrous oxide + reduced acceptor. MF
GO:0050305 strombine dehydrogenase activity Catalysis of the reaction: N-(carboxymethyl)-D-alanine + NAD+ + H2O = glycine + pyruvate + NADH. MF
GO:0050306 sucrose 1F-fructosyltransferase activity Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose. MF
GO:0050307 sucrose-phosphatase activity Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. MF
GO:0018559 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate. MF
GO:0018558 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon. MF
GO:0018555 phenanthrene dioxygenase activity Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ = cis-3,4-dihydroxy-3,4-dihydrophenanthrene. MF
GO:0018554 1,2-dihydroxynaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached. MF
GO:0018557 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid. MF
GO:0018556 2,2',3-trihydroxybiphenyl dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate). MF
GO:0018551 hydrogensulfite reductase activity Catalysis of the reaction: O3S-S-SO3(2-) + acceptor + 2 H2O + OH- = 3 HSO3(-) + reduced acceptor. MF
GO:0018550 tetrachloro-p-hyrodoquinone reductive dehalogenase activity Catalysis of the reaction: organohalide + 2 GSH = GSSG + HCl + RH. Substrates are 2,3,5,6-tetrachlorohydroquinone (TeCH) (forms 2,3,6-trichlorohydroquinone (TrCH)) and 2,3,6-trichlorohydroquinone (TrCH) (forms 2,6-dichlorohydroquinone (DiCH)). MF
GO:0018553 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate. MF
GO:0018552 methyl-coenzyme-M reductase activity Catalysis of the reaction: methyl-coenzyme-M + HTP = CoM-S-S-HTP + methane. MF
GO:0019202 amino acid kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate. MF
GO:0019203 carbohydrate phosphatase activity Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. MF
GO:0019200 carbohydrate kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. MF
GO:0019201 nucleotide kinase activity Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. MF
GO:0019206 nucleoside kinase activity Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. MF
GO:0019207 kinase regulator activity Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. MF
GO:0019204 nucleotide phosphatase activity NA MF
GO:0019205 nucleobase, nucleoside, nucleotide kinase activity Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. MF
GO:0019208 phosphatase regulator activity Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. MF
GO:0019209 kinase activator activity Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. MF
GO:0007159 leukocyte adhesion The attachment of an adhesion molecule on a leukocyte cell to a nonidentical adhesion molecule in an adjacent cell. BP
GO:0007158 neuron adhesion The attachment of an adhesion molecule on a neuronal cell to a nonidentical adhesion molecule in an adjacent cell. BP
GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. BP
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. BP
GO:0007157 heterophilic cell adhesion The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. BP
GO:0007156 homophilic cell adhesion The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell. BP
GO:0052278 negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052279 modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052276 positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052277 modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052274 positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052275 negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052272 positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052273 positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052270 positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052271 positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0015434 cadmium-transporting ATPase activity Catalysis of the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole). MF
GO:0018618 anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3. MF
GO:0015436 capsular-polysaccharide-transporting ATPase activity Catalysis of the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out). MF
GO:0015431 glutathione S-conjugate-exporting ATPase activity Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) = ADP + phosphate + glutathione S-conjugate(out). MF
GO:0015430 glycerol-3-phosphate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in). MF
GO:0015433 peptide antigen-transporting ATPase activity Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate. MF
GO:0015432 bile acid-exporting ATPase activity Catalysis of the reaction: bile acid(in) + ATP + H2O = bile acid(out) + ADP + phosphate. MF
GO:0018612 dibenzothiophene dioxygenase activity Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene. MF
GO:0018613 9-fluorenone dioxygenase activity Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone. MF
GO:0018610 dibenzofuran 4,4a-dioxygenase activity Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+. MF
GO:0018611 toluate dioxygenase activity Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate. MF
GO:0018616 trihydroxytoluene dioxygenase activity Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate. MF
GO:0018617 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol. MF
GO:0018614 ethylbenzene dioxygenase activity Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene. MF
GO:0018615 2-indanone monooxygenase activity Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone. MF
GO:0016168 chlorophyll binding Interacting selectively with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. MF
GO:0016169 bacteriochlorophyll c binding Interacting selectively with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria. MF
GO:0016162 cellulose 1,4-beta-cellobiosidase activity Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains. MF
GO:0016163 nitrogenase activity Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. MF
GO:0016160 amylase activity Catalysis of the hydrolysis of amylose or an amylose derivative. MF
GO:0016161 beta-amylase activity Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. MF
GO:0016166 phytoene dehydrogenase activity Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene. MF
GO:0042327 positive regulation of phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphoric groups to a molecule. BP
GO:0016164 Mo-molybdopterin oxidoreductase activity NA MF
GO:0016165 lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. MF
GO:0042326 negative regulation of phosphorylation Any process that stops, prevents or decreases the rate of addition of phosphoric groups to a molecule. BP
GO:0046248 alpha-pinene biosynthetic process The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. BP
GO:0046249 alpha-pinene catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. BP
GO:0046246 terpene biosynthetic process The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units. BP
GO:0046247 terpene catabolic process The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units. BP
GO:0046244 salicylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. BP
GO:0018746 phenanthrene-3,4-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene. MF
GO:0006276 plasmid maintenance The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division. BP
GO:0008979 prophage integrase activity NA MF
GO:0030289 protein phosphatase 4 complex The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit. CC
GO:0030288 periplasmic space (sensu ProteoBacteria) The region between the inner (cytoplasmic) membrane and outer membrane. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0030287 periplasmic space (sensu Fungi) The region between the plasma membrane and the cell wall. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0030286 dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. CC
GO:0030285 integral to synaptic vesicle membrane Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0030284 estrogen receptor activity Combining with estrogen to initiate a change in cell activity. MF
GO:0030283 3(or 17)beta-hydroxysteroid dehydrogenase activity Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. MF
GO:0030282 bone mineralization The deposition of calcium phosphate in bone tissue. BP
GO:0030281 structural constituent of cutaneous appendage The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers. MF
GO:0030280 structural constituent of epidermis The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure. MF
GO:0018743 phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene. MF
GO:0006916 anti-apoptosis A process which directly inhibits any of the steps required for cell death by apoptosis. BP
GO:0008973 phosphopentomutase activity Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. MF
GO:0008970 phospholipase A1 activity Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion. MF
GO:0008976 polyphosphate kinase activity Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). MF
GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. BP
GO:0006910 phagocytosis, recognition The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. BP
GO:0008975 pitrilysin activity Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon. MF
GO:0007565 pregnancy The physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. BP
GO:0031626 beta-endorphin binding Interacting selectively with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin. MF
GO:0031627 telomeric loop formation The process by which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region. BP
GO:0031624 ubiquitin conjugating enzyme binding Interacting selectively with a ubiquitin conjugating enzyme, any of the E2 proteins. MF
GO:0031625 ubiquitin protein ligase binding Interacting selectively with a ubiquitin protein ligase enzyme, any of the E3 proteins. MF
GO:0031622 positive regulation of fever Any process that activates or increases the frequency, rate, or extent of fever. BP
GO:0031623 receptor internalization The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling. BP
GO:0031620 regulation of fever Any process that modulates the frequency, rate, or extent of fever. BP
GO:0031621 negative regulation of fever Any process that stops, prevents, or reduces the frequency, rate, or extent of fever. BP
GO:0031628 opioid receptor binding Interacting selectively with an opioid receptor. MF
GO:0031629 synaptic vesicle fusion to presynaptic membrane Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. BP
GO:0022415 viral reproductive process A reproductive process involved in viral reproduction. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. BP
GO:0022414 reproductive process A biological process in which new individuals are produced by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. BP
GO:0022417 protein maturation via protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. BP
GO:0022416 bristle development The process whose specific outcome is the progression of the bristle over time, from its formation to the mature structure. A bristle is an insect sensory organ. BP
GO:0022411 cellular structure disassembly A cellular process that results in the breakdown of a part of the cell. BP
GO:0022410 circadian sleep/wake cycle process A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. BP
GO:0022413 reproductive process in single-celled organism A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism. BP
GO:0022412 reproductive cellular process in multicellular organism A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. BP
GO:0002848 positive regulation of T cell tolerance induction to tumor cell Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell. BP
GO:0002849 regulation of peripheral T cell tolerance induction Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction. BP
GO:0009746 response to hexose stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. BP
GO:0009747 hexokinase-dependent signaling A series of molecular signals mediated by hexose and dependent on the detection of hexokinase. BP
GO:0009744 response to sucrose stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. BP
GO:0009745 sucrose mediated signaling A series of molecular signals mediated by the detection of sucrose. BP
GO:0009742 brassinosteroid mediated signaling A series of molecular signals mediated by the detection of brassinosteroid. BP
GO:0009743 response to carbohydrate stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. BP
GO:0009740 gibberellic acid mediated signaling A series of molecular signals mediated by the detection of gibberellic acid. BP
GO:0009741 response to brassinosteroid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. BP
GO:0009748 hexokinase-independent signaling A series of molecular signals mediated by hexose and independent of hexokinase. BP
GO:0009749 response to glucose stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. BP
GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. BP
GO:0008298 intracellular mRNA localization The processes by which RNA is transported to, or maintained in, a specific location within the cell. BP
GO:0008293 torso signaling pathway The series of molecular signals generated as a consequence of the torso transmembrane receptor tyrosine kinase binding to its physiological ligand. BP
GO:0008292 acetylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. BP
GO:0008291 acetylcholine metabolic process The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. BP
GO:0008290 F-actin capping protein complex A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. CC
GO:0008297 single-stranded DNA specific exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. MF
GO:0008296 3'-5'-exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. MF
GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. BP
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. MF
GO:0002598 regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. BP
GO:0002599 negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. BP
GO:0002596 negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. BP
GO:0002597 positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. BP
GO:0002594 positive regulation of antigen processing and presentation via MHC class Ib Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. BP
GO:0002595 regulation of antigen processing and presentation of peptide antigen via MHC class Ib Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib. BP
GO:0002592 regulation of antigen processing and presentation via MHC class Ib Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. BP
GO:0002593 negative regulation of antigen processing and presentation via MHC class Ib Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib. BP
GO:0002590 negative regulation of antigen processing and presentation of peptide antigen via MHC class I Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. BP
GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. BP
GO:0045498 sex comb development The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg. BP
GO:0045499 chemorepellant activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. MF
GO:0045492 xylan biosynthetic process The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone. BP
GO:0045493 xylan catabolic process The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone. BP
GO:0045490 pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. BP
GO:0045491 xylan metabolic process The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone. BP
GO:0045496 male analia development (sensu Endopterygota) The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia develop from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045497 female analia development (sensu Endopterygota) The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia develop from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045494 photoreceptor cell maintenance Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. BP
GO:0045495 pole plasm Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. CC
GO:0042152 RNA-mediated DNA recombination The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele. BP
GO:0042153 RPTP-like protein binding Interacting selectively with proteins with similar structure/function to receptor protein tyrosine phosphatases. MF
GO:0042150 plasmid recombination NA BP
GO:0042151 nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. CC
GO:0047388 adenylyl-[glutamate-ammonia ligase] hydrolase activity Catalysis of the reaction: H2O + adenylyl-GS = glutaminesyn-oligomer + AMP. MF
GO:0042157 lipoprotein metabolic process The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. BP
GO:0047384 [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]. MF
GO:0047385 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]. MF
GO:0042158 lipoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. BP
GO:0042159 lipoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. BP
GO:0047380 ADP-dependent medium-chain-acyl-CoA hydrolase activity Catalysis of the reaction: H2O + acyl-CoA = an acid + CoA. MF
GO:0047381 dodecanoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]. MF
GO:0047382 methylphosphothioglycerate phosphatase activity Catalysis of the reaction: H2O + S-methyl-3-phospho-1-thio-D-glycerate = phosphate + S-methyl-1-thio-D-glycerate. MF
GO:0047383 guanidinodeoxy-scyllo-inositol-4-phosphatase activity Catalysis of the reaction: H2O + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate = phosphate + 1-guanidino-1-deoxy-scyllo-inositol. MF
GO:0045728 respiratory burst after phagocytosis A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity. BP
GO:0045729 respiratory burst at fertilization The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes. BP
GO:0045724 positive regulation of flagellum biogenesis Any process that activates or increases the frequency, rate or extent of the formation of a flagellum. BP
GO:0045725 positive regulation of glycogen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. BP
GO:0045726 positive regulation of integrin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. BP
GO:0045727 positive regulation of protein biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. BP
GO:0045720 negative regulation of integrin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. BP
GO:0045721 negative regulation of gluconeogenesis Any process that stops, prevents or reduces the frequency, rate or extent of gluconeogenesis. BP
GO:0045722 positive regulation of gluconeogenesis Any process that activates or increases the frequency, rate or extent of gluconeogenesis. BP
GO:0045723 positive regulation of fatty acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. BP
GO:0047656 alpha,alpha-trehalose phosphorylase activity Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate. MF
GO:0047657 alpha-1,3-glucan synthase activity Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1. MF
GO:0047654 alliin lyase activity Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate. MF
GO:0047655 allyl-alcohol dehydrogenase activity Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + NADPH. MF
GO:0047652 allantoate deiminase activity Catalysis of the reaction: 2 H2O + 2 allantoate = O2 + 2 CO2 + 2 NH3 + 2 ureidoglycine. MF
GO:0047653 allantoin racemase activity Catalysis of the reaction: (S)(+)-allantoin = (R)(-)-allantoin. MF
GO:0047650 alkylglycerone kinase activity Catalysis of the reaction: ATP + O-alkylglycerone = ADP + O-alkylglycerone phosphate. MF
GO:0047651 alkylhalidase activity Catalysis of the reaction: bromochloromethane + H2O = formaldehyde + bromide + chloride. MF
GO:0047658 alpha-amino-acid esterase activity Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol. MF
GO:0047659 alpha-santonin 1,2-reductase activity Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+. MF
GO:0048839 inner ear development The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. BP
GO:0048838 release of seed from dormancy The processes by which the dormant state comes to an end in a seed. BP
GO:0048833 regulation of floral organ number Any process that modulates the number of petals formed in a flower. BP
GO:0048832 regulation of organ number The regionalization process that modulates the quantity of a particular type of organ. BP
GO:0048831 regulation of shoot development Any process that modulates the frequency, rate or extent of shoot development. BP
GO:0048830 adventitious root development The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot. BP
GO:0048837 sorus development The process whose specific outcome is the progression of the sorus over time, from its formation to the mature structure. A sorus is a mass of spores. BP
GO:0048836 positive regulation of petal number Any process that increases the number of petals produced in a developing flower. BP
GO:0048835 negative regulation of petal number Any process that reduces the number of petals produced in a developing flower. BP
GO:0048834 regulation of petal number Any process that modulates the number of petals formed in a flower. BP
GO:0002035 brain renin-angiotensin system The process by which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system. BP
GO:0002034 renin-angiotensin regulation of blood vessel size The process where the diameter of a blood vessel is changed due to activity of the renin-angiotensin system. BP
GO:0002037 negative regulation of L-glutamate transport Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate transport. BP
GO:0002036 regulation of L-glutamate transport Any process that modulates the frequency, rate or extent of L-glutamate transport. BP
GO:0002031 G-protein coupled receptor internalization The process by which a G-protein coupled receptor is taken up into an endocytic vesicle. BP
GO:0002030 inhibitory G-protein coupled receptor phosphorylation The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphoric group to its third intracellular loop consensu thes site. BP
GO:0002033 angiotensin mediated vasodilation during regulation of blood pressure The process that increases the size of a blood vessel via the renin-angiotensin system. BP
GO:0002032 arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins. BP
GO:0002039 p53 binding Interacting selectively with one of the p53 family of proteins. MF
GO:0002038 positive regulation of L-glutamate transport Any process that activates or increases the frequency, rate or extent of L-glutamate transport. BP
GO:0052418 metabolism by organism of protein in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052419 metabolism by host of substance in symbiont The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052416 metabolism by host of symbiont macromolecule The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052417 metabolism by host of symbiont protein The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052414 metabolism by host of symbiont glucan The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052415 metabolism by organism of glucan in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052412 metabolism by host of symbiont cell wall pectin The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052413 metabolism by organism of cell wall pectin in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052410 metabolism by host of symbiont cell wall chitin The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052411 metabolism by organism of cell wall chitin in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells. BP
GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells. BP
GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells. BP
GO:0003859 3-hydroxybutyryl-CoA dehydratase activity Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O. MF
GO:0006824 cobalt ion transport The directed movement of cobalt (Co) ions into, out of, within or between cells. BP
GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells. BP
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity Catalysis of the reaction: 3-beta-hydroxy-delta(5)-steroid + NAD+ = 3-oxo-delta(5)-steroid + NADH + H+. MF
GO:0003855 3-dehydroquinate dehydratase activity Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. MF
GO:0006828 manganese ion transport The directed movement of manganese (Mn) ions into, out of, within or between cells. BP
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. MF
GO:0003850 2-deoxyglucose-6-phosphatase activity Catalysis of the reaction: 2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate. MF
GO:0003851 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine. MF
GO:0003852 2-isopropylmalate synthase activity Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA. MF
GO:0003853 2-methylacyl-CoA dehydrogenase activity Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor. MF
GO:0019509 methionine salvage The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. BP
GO:0019508 2,5-dihydroxypyridine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate. BP
GO:0019505 resorcinol metabolic process The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic. BP
GO:0019504 stachydrine catabolic process The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline. BP
GO:0019507 pyridine metabolic process The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. BP
GO:0019506 phenylmercury acetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group. BP
GO:0019501 arsonoacetate catabolic process The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom. BP
GO:0019500 cyanide catabolic process The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. BP
GO:0019503 stachydrine biosynthetic process The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline. BP
GO:0019502 stachydrine metabolic process The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants. BP
GO:0042963 phage assembly A late phase of bacteriophage replication during which all the components necessary for the formation of a mature virion collect at a particular site in the bacterial cell and the basic structure of the virus particle is formed. BP
GO:0042962 acridine:hydrogen antiporter activity Catalysis of the reaction: H+(out) + acridine(in) = H+(in) + acridine(out). MF
GO:0042961 antimonite-transporting ATPase activity Catalysis of the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out). MF
GO:0042960 antimonite porter activity Catalysis of the movement of antimonite by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. MF
GO:0004086 carbamoyl-phosphate synthase activity Catalysis of a reaction that results in the formation of carbamoyl phosphate. MF
GO:0042966 biotin carboxyl carrier protein biosynthetic process The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase. BP
GO:0042965 glutaredoxin biosynthetic process The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase. BP
GO:0042964 thioredoxin biosynthetic process The chemical reactions and pathways resulting in the formation of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. BP
GO:0042969 lactone transport The directed movement of lactone, any of a series of organic compounds, regarded as anhydrides of certain hydroxy acids, into, out of, within or between cells. BP
GO:0042968 homoserine transport The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of, within or between cells. BP
GO:0000509 Rpd3S complex A multisubunit histone deacetylase complex that is involved in intragenic transcription repression through histone deacetylation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3. CC
GO:0000508 Rpd3L complex A multisubunit histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p. CC
GO:0000503 proteasome core complex (sensu Bacteria) A multisubunit, barrel shaped protease complex. This complex consists of fourteen subunits of two distinct but related polypeptides. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0000502 proteasome complex (sensu Eukaryota) A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and the regulatory particle that caps the proteasome core complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0000501 flocculation via cell wall protein-carbohydrate interaction Mannose-sensitive, nonsexual aggregation of cells mediated by protein-carbohydrate (flocculin-mannan) interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. BP
GO:0000500 RNA polymerase I upstream activating factor complex A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p. CC
GO:0000507 1-acylglycerophosphocholine O-acyltransferase Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. MF
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. CC
GO:0000504 proteasome regulatory particle (sensu Bacteria) A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0050119 N-acetylglucosamine deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate. MF
GO:0050118 N-acetyldiaminopimelate deacetylase activity Catalysis of the reaction: N-acetyl-LL2,6-diaminoheptanedioate + H2O = acetate + LL2,6-diaminoheptanedioate. MF
GO:0050111 mycocerosate synthase activity Catalysis of the reaction: acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+ = multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+. MF
GO:0050110 mucinaminylserine mucinaminidase activity Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine. MF
GO:0050113 inositol oxygenase activity Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O. MF
GO:0050112 inositol 2-dehydrogenase activity Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. MF
GO:0050115 myosin-light-chain-phosphatase activity Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. MF
GO:0050114 myo-inosose-2 dehydratase activity Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O. MF
GO:0050117 N-acetyl-beta-alanine deacetylase activity Catalysis of the reaction: N-acetyl-beta-alanine + H2O = acetate + beta-alanine. MF
GO:0050116 N,N-dimethylformamidase activity Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate. MF
GO:0051444 negative regulation of ubiquitin ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. BP
GO:0005844 polysome Several ribosomes bound to one mRNA. CC
GO:0051446 positive regulation of progression through meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. BP
GO:0051447 negative regulation of progression through meiotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of progression through the meiotic cell cycle. BP
GO:0051440 regulation of ubiquitin ligase activity during meiotic cell cycle A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle. BP
GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. CC
GO:0051442 negative regulation of ubiquitin ligase activity during meiotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle. BP
GO:0051443 positive regulation of ubiquitin ligase activity Any process that activates, maintains or increases the rate of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. BP
GO:0005849 mRNA cleavage factor complex Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. CC
GO:0005848 mRNA cleavage stimulating factor complex A protein complex required for mRNA cleavage but not for poly(A) addition. CC
GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. MF
GO:0004103 choline kinase activity Catalysis of the reaction: ATP + choline = ADP + O-phosphocholine. MF
GO:0004102 choline O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + choline = CoA + O-acetylcholine. MF
GO:0004100 chitin synthase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n+1). MF
GO:0004107 chorismate synthase activity Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. MF
GO:0004106 chorismate mutase activity Catalysis of the reaction: chorismate = prephenate. MF
GO:0004105 choline-phosphate cytidylyltransferase activity Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. MF
GO:0004104 cholinesterase activity Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. MF
GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. BP
GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. BP
GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. BP
GO:0006010 glucose 6-phosphate utilization NA BP
GO:0006017 deoxyribose 1,5-bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose. BP
GO:0006016 2-deoxyribose 1-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. BP
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. BP
GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. BP
GO:0006019 deoxyribose 5-phosphate phosphorylation The process of introducing a phosphoric group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate. BP
GO:0006018 deoxyribose 1-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. BP
GO:0014047 glutamate secretion The regulated release of glutamate by a cell or group of cells. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. BP
GO:0014046 dopamine secretion The regulated release of dopamine by a cell or group of cells. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone. BP
GO:0014045 establishment of blood-brain barrier Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. BP
GO:0014044 Schwann cell development The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. BP
GO:0014043 negative regulation of neuron maturation Any process that stops, prevents or reduces the frequency, rate or extent of neuron maturation. BP
GO:0014042 positive regulation of neuron maturation Any process that activates or increases the frequency, rate or extent of neuron maturation. BP
GO:0014041 regulation of neuron maturation Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. BP
GO:0014040 positive regulation of Schwann cell differentiation Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation. BP
GO:0014049 positive regulation of glutamate secretion Any process that activates or increases the frequency, rate or extent of the regulated release of glutamate. BP
GO:0014048 regulation of glutamate secretion Any process that modulates the frequency, rate or extent of the regulated release of glutamate. BP
GO:0015608 carbohydrate-importing ATPase activity Catalysis of the reaction: ATP + H2O + carbohydrate(out) = ADP + phosphate + carbohydrate(in). MF
GO:0015609 maltooligosaccharide-importing ATPase activity Catalysis of the reaction: ATP + H2O + maltooligosaccharide(out) = ADP + phosphate + maltooligosaccharide(in). MF
GO:0015603 iron chelate transporter activity Enables the directed movement of an iron chelate into, out of, within or between cells. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. MF
GO:0015606 spermidine transporter activity Enables the directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, into, out of, within or between cells. MF
GO:0015607 fatty acyl CoA transporter activity Enables the directed movement of a fatty acyl CoA group into, out of, within or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A moiety attached to it. MF
GO:0015604 phosphonate transporter activity Enables the directed movement of phosphonate into, out of, within or between cells. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). MF
GO:0015605 organophosphate ester transporter activity Enables the directed movement of organophosphate esters into, out of, within or between cells. Organophosphate esters are small organic molecules containing phosphate ester bonds. MF
GO:0047414 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity Catalysis of the reaction: 2 H2O + 2-(hydroxymethyl)-3-(acetamidomethylene)succinate = CO2 + NH3 + 2-(hydroxymethyl)-4-oxobutanoate + acetate. MF
GO:0047415 D-benzoylarginine-4-nitroanilide amidase activity Catalysis of the reaction: H2O + N-benzoyl-D-arginine-4-nitroanilide = N-benzoyl-D-arginine + 4-nitroaniline. MF
GO:0047416 arylalkyl acylamidase activity Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine. MF
GO:0047417 N-carbamoyl-D-amino acid hydrolase activity Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid. MF
GO:0047410 N-formylmethionylaminoacyl-tRNA deformylase activity Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate. MF
GO:0047411 2-(acetamidomethylene)succinate hydrolase activity Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate. MF
GO:0047412 N-(long-chain-acyl)ethanolamine deacylase activity Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanol-amine + a fatty acid. MF
GO:0047413 N(alpha)-benzyloxycarbonylleucine hydrolase activity Catalysis of the reaction: H2O + N(alpha)-benzyloxycarbonyl-L-leucine = L-leucine + CO2 + benzyl alcohol. MF
GO:0047418 phthalyl amidase activity Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine. MF
GO:0047419 N-acetylgalactosamine-6-phosphate deacetylase activity Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate. MF
GO:0043564 Ku70:Ku80 complex Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. CC
GO:0043565 sequence-specific DNA binding Interacting selectively with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. MF
GO:0043566 structure-specific DNA binding Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. MF
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. BP
GO:0043560 insulin receptor substrate binding Interacting selectively with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. MF
GO:0043561 regulation of translation initiation in response to osmotic stress Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. BP
GO:0016559 peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. BP
GO:0043563 odorant transporter activity Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of, within or between cells. MF
GO:0016557 peroxisome membrane biogenesis The assembly and arrangement of the membrane of a peroxisome. BP
GO:0016556 mRNA modification The covalent alteration of one or more nucleotides within mRNA, resulting in a change in the properties of the mRNA. BP
GO:0016555 uridine to cytidine editing The conversion of a uridine residue to cytosine in an RNA molecule by amination. BP
GO:0016554 cytidine to uridine editing The conversion of a cytosine residue to uridine in an RNA molecule by deamination. BP
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. BP
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling. BP
GO:0016551 posttranscriptional insertion or deletion editing The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription. BP
GO:0016550 insertion or deletion editing The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription. BP
GO:0042130 negative regulation of T cell proliferation Any process that stops, prevents or reduces the rate or extent of T cell proliferation. BP
GO:0045818 negative regulation of glycogen catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. BP
GO:0045819 positive regulation of glycogen catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. BP
GO:0045816 negative regulation of global transcription from RNA polymerase II promoter Any process that stops, prevents or reduces the frequency, rate or extent of global transcription from an RNA polymerase II promoter. BP
GO:0045817 positive regulation of global transcription from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of global transcription from an RNA polymerase II promoter. BP
GO:0045814 negative regulation of gene expression, epigenetic Any epigenetic process that stops, prevents or reduces the rate of gene expression. BP
GO:0045815 positive regulation of gene expression, epigenetic Any epigenetic process that activates or increases the rate of gene expression. BP
GO:0045812 negative regulation of frizzled-2 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the frizzled-2 signaling pathway. BP
GO:0045813 positive regulation of frizzled-2 signaling pathway Any process that activates or increases the frequency, rate or extent of the frizzled-2 signaling pathway. BP
GO:0045810 negative regulation of frizzled signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the frizzled signaling pathway. BP
GO:0045811 positive regulation of frizzled signaling pathway Any process that activates or increases the frequency, rate or extent of the frizzled signaling pathway. BP
GO:0042132 fructose-bisphosphatase activity Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. MF
GO:0048817 negative regulation of hair follicle maturation Any process that stops, prevents or reduces the frequency, rate or extent of hair follicle maturation. BP
GO:0030746 isoflavone 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone. MF
GO:0030747 indolepyruvate C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone. MF
GO:0030744 luteolin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxyflavone = S-adenosyl-L-homocysteine + 5,7,4'-trihydroxy-3'-methoxyflavone. MF
GO:0030745 dimethylhistidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + NN1,NN1-dimethyl-L-histidine = S-adenosyl-L-homocysteine + NN1,NN1,NN1-trimethyl-L-histidine. MF
GO:0030742 GTP-dependent protein binding Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. MF
GO:0030743 rRNA (adenosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine. MF
GO:0030740 inositol 3-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-3-O-methyl-myo-inositol. MF
GO:0030741 inositol 1-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-1-O-methyl-myo-inositol. MF
GO:0030748 amine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. MF
GO:0030749 loganate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin. MF
GO:0031299 taurine-pyruvate aminotransferase activity Catalysis of the reaction: taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde. MF
GO:0031298 replication fork protection complex A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. CC
GO:0031293 membrane protein intracellular domain proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. BP
GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang. BP
GO:0031291 Ran protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state. BP
GO:0031290 retinal ganglion cell axon guidance The process by which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. BP
GO:0031297 collapsed replication fork processing The process by which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired by a recombinational mechanism. BP
GO:0031296 B cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation. BP
GO:0031295 T cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. BP
GO:0031294 lymphocyte costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. BP
GO:0000393 spliceosomal conformational changes to generate catalytic conformation Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. BP
GO:0045108 regulation of intermediate filament polymerization and/or depolymerization Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases. BP
GO:0045109 intermediate filament organization Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. BP
GO:0045104 intermediate filament cytoskeleton organization and biogenesis The assembly and arrangement of cytoskeletal structures comprising intermediate filaments and their associated proteins. BP
GO:0045105 intermediate filament polymerization and/or depolymerization Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament. BP
GO:0045106 intermediate filament depolymerization Disassembly of intermediate filaments by the removal of component monomers from a filament. BP
GO:0045107 intermediate filament polymerization Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain. BP
GO:0045103 intermediate filament-based process Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. BP
GO:0018920 glyphosate metabolic process The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond. BP
GO:0018921 3-hydroxybenzyl alcohol metabolic process The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum. BP
GO:0018922 iprodione metabolic process The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium). BP
GO:0018923 limonene metabolic process The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. It is the most widespread terpene in the world and is synthesized by more than 300 plants. (+)-(4R)-limonene is its most widespread form. BP
GO:0018924 mandelate metabolic process The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. BP
GO:0018925 m-cresol metabolic process The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes. BP
GO:0018926 methanesulfonic acid metabolic process The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide. BP
GO:0018928 methyl ethyl ketone metabolic process The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints. BP
GO:0018929 methyl fluoride metabolic process The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils. BP
GO:0008316 structural constituent of vitelline membrane (sensu Insecta) The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). MF
GO:0008317 gurken receptor binding Interacting selectively with the gurken growth factor receptor. MF
GO:0008314 gurken receptor signaling pathway The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken. BP
GO:0008315 meiotic G2/MI transition The cell cycle process whereby a cell progresses from meiotic prophase to metaphase I. BP
GO:0008312 7S RNA binding Interacting selectively with 7S RNA, the RNA component of the signal recognition particle (SRP). MF
GO:0008313 gurken receptor activity Combining with the ligand Gurken to initiate a change in cell activity. MF
GO:0008310 single-stranded DNA specific 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. MF
GO:0008311 double-stranded DNA specific 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. MF
GO:0008318 protein prenyltransferase activity Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. MF
GO:0008319 prenyl protein specific endopeptidase activity NA MF
GO:0032241 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells. BP
GO:0032240 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells. BP
GO:0032243 negative regulation of nucleoside transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells. BP
GO:0032242 regulation of nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells. BP
GO:0032245 regulation of purine nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells. BP
GO:0032244 positive regulation of nucleoside transport Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells. BP
GO:0032247 negative regulation of purine nucleoside transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells. BP
GO:0032246 regulation of pyrimidine nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of, within or between cells. BP
GO:0032249 regulation of adenosine transport Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells. BP
GO:0032248 positive regulation of purine nucleoside transport Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells. BP
GO:0042343 indole glucosinolate metabolic process The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan. BP
GO:0042342 cyanogenic glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. BP
GO:0042341 cyanogenic glycoside metabolic process The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. BP
GO:0042340 keratan sulfate catabolic process The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. BP
GO:0042347 negative regulation of NF-kappaB import into nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0042346 positive regulation of NF-kappaB import into nucleus Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0042345 regulation of NF-kappaB import into nucleus Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0042344 indole glucosinolate catabolic process The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan. BP
GO:0042349 guiding stereospecific synthesis activity The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis. MF
GO:0042348 NF-kappaB import into nucleus The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0006251 dCDP catabolic process The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate. BP
GO:0006253 dCTP catabolic process The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate. BP
GO:0006254 CTP catabolic process The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate. BP
GO:0006257 dUDP catabolic process The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate. BP
GO:0006256 UDP catabolic process The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate. BP
GO:0006259 DNA metabolic process The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. BP
GO:0006258 UDP-glucose catabolic process The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. BP
GO:0005786 signal recognition particle (sensu Eukaryota) A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0005787 signal peptidase complex A multi subunit protease complex located in the endoplasmic reticulum membrane that cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. CC
GO:0000369 U12-type nuclear mRNA 5'-splice site recognition Recognition of the intron 5'-splice site by components of the assembling U12-type spliceosome. The U11 snRNP is thought to play a role in recognition of the U12-type 5'-splice site. BP
GO:0000368 U2-type nuclear mRNA 5'-splice site recognition Recognition of the intron 5'-splice site by components of the assembling U2-type spliceosome. This may involve binding of U1 snRNA and/or U6 snRNA to intron sequences. BP
GO:0005782 peroxisomal matrix The material contained within the membrane of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. CC
GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). CC
GO:0005780 extrinsic to intraperoxisomal membrane Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region. CC
GO:0005781 peroxisome targeting signal receptor complex NA CC
GO:0000363 first U12-type spliceosomal transesterification activity Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins. MF
GO:0000362 first U2-type spliceosomal transesterification activity Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins. MF
GO:0000361 cis assembly of U12-type pre-catalytic spliceosome Assembly of a U12-type spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the U4atac-Uatac6/U5 tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. BP
GO:0000360 cis assembly of U2-type pre-catalytic spliceosome Assembly of a U2-type spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the U4-U6/U5 tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. BP
GO:0000367 second U12-type spliceosomal transesterification activity Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins. MF
GO:0000366 intergenic nuclear mRNA trans splicing The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing. BP
GO:0005788 endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum. CC
GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. CC
GO:0047321 diphosphate-protein phosphotransferase activity Catalysis of the reaction: microsomal-membrane protein + pyrophosphate = phosphate + O-phospho-microsomal-membrane protein. MF
GO:0042134 rRNA primary transcript binding Interacting selectively with an unprocessed ribosomal RNA transcript. MF
GO:0047327 glycerol-3-phosphate-glucose phosphotransferase activity Catalysis of the reaction: beta-D-glucose + glycerol-3-phosphate = glucose-6-phosphate + glycerol. MF
GO:0006789 bilirubin conjugation NA BP
GO:0006788 heme oxidation NA BP
GO:0047324 phosphoenolpyruvate-glycerone phosphotransferase activity Catalysis of the reaction: dihydroxy-acetone + phosphoenolpyruvate = dihydroxy-acetone-phosphate + pyruvate. MF
GO:0006783 heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. BP
GO:0006782 protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. BP
GO:0006781 succinyl-CoA pathway The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX. BP
GO:0006780 uroporphyrinogen III biosynthetic process The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. BP
GO:0006787 porphyrin catabolic process The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. BP
GO:0006786 heme c biosynthetic process The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f. BP
GO:0006785 heme b biosynthetic process The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. BP
GO:0006784 heme a biosynthetic process The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3. BP
GO:0000099 sulfur amino acid transporter activity Enables the directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells. MF
GO:0000098 sulfur amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. BP
GO:0000095 S-adenosylmethionine transporter activity Enables the directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of, within or between cells. MF
GO:0000097 sulfur amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. BP
GO:0000096 sulfur amino acid metabolic process The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. BP
GO:0000091 mitotic anaphase A Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles. BP
GO:0000090 mitotic anaphase Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other. BP
GO:0000093 mitotic telophase Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. BP
GO:0000092 mitotic anaphase B Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart. BP
GO:0004789 thiamin-phosphate diphosphorylase activity Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate. MF
GO:0004788 thiamin diphosphokinase activity Catalysis of the reaction: ATP + thiamin = AMP + thiamin diphosphate. MF
GO:0004785 copper, zinc superoxide dismutase activity Catalysis of the reaction: 2 peroxide radical + 2 H+ = O2 + H2O2. MF
GO:0004784 superoxide dismutase activity Catalysis of the reaction: 2 peroxide radical + 2 H+ = O2 + H2O2. MF
GO:0004787 thiamin-pyrophosphatase activity Catalysis of the reaction: TDP + H2O = TMP + phosphate. MF
GO:0004781 sulfate adenylyltransferase (ATP) activity Catalysis of the reaction: ATP + SO4(2-) (sulfate) = diphosphate + adenylylsulfate. MF
GO:0004780 sulfate adenylyltransferase (ADP) activity Catalysis of the reaction: ADP + SO4(2-) (sulfate) = phosphate + adenylylsulfate. MF
GO:0004783 sulfite reductase (NADPH) activity Catalysis of the reaction: H2S + 3 NADP+ + 3 H2O = SO3(2-) (sulfite) + 3 NADPH + 3 H+. MF
GO:0004782 sulfinoalanine decarboxylase activity Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. MF
GO:0050739 peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium The posttranslational cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. BP
GO:0050738 fructosyltransferase activity Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid. MF
GO:0043179 rhythmic excitation Processes involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit. BP
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. BP
GO:0050730 regulation of peptidyl-tyrosine phosphorylation Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. BP
GO:0050733 RS domain binding Interacting selectively with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. MF
GO:0009837 ripening, non-climacteric A ripening process that does not involve a respiratory burst. BP
GO:0050735 N-malonyltransferase activity Catalysis of the transfer of an malonyl group to a nitrogen atom on the acceptor molecule. MF
GO:0050734 hydroxycinnamoyltransferase activity Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule. MF
GO:0050737 O-hydroxycinnamoyltransferase activity Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule. MF
GO:0050736 O-malonyltransferase activity Catalysis of the transfer of an malonyl group to an oxygen atom on the acceptor molecule. MF
GO:0043177 organic acid binding Interacting selectively with an organic acid, any acidic compound containing carbon in covalent linkage. MF
GO:0048657 tapetal cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a tapetal cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. BP
GO:0048656 tapetal layer formation The process that gives rise to the tapetal layer. This process pertains to the initial formation of a structure from unspecified parts. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. BP
GO:0048648 caste determination The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. BP
GO:0048649 caste determination, influence by genetic factors The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. BP
GO:0002208 somatic diversification of immunoglobulins during immune response The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response. BP
GO:0002209 behavioral defense response A behavioral response seeking to protect an organism from an a perceived external threat to that organism. BP
GO:0005250 A-type (transient outward) potassium channel activity NA MF
GO:0048641 regulation of skeletal muscle development Any process that modulates the frequency, rate or extent of skeletal muscle development. BP
GO:0005252 open rectifier potassium channel activity NA MF
GO:0005253 anion channel activity NA MF
GO:0005254 chloride channel activity NA MF
GO:0048645 organ formation The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. BP
GO:0048646 anatomical structure formation The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. BP
GO:0002205 somatic hypermutation of immunoglobulin genes during immune response Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of an immune response. BP
GO:0004129 cytochrome-c oxidase activity Catalysis of the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. MF
GO:0004128 cytochrome-b5 reductase activity Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5). MF
GO:0004121 cystathionine beta-lyase activity Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. MF
GO:0004120 photoreceptor cyclic-nucleotide phosphodiesterase activity Catalysis of the hydrolysis of bonds in a cyclic nucleotide (nucleoside cyclic phosphate + H2O = nucleoside phosphate). MF
GO:0004123 cystathionine gamma-lyase activity Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate. MF
GO:0004122 cystathionine beta-synthase activity Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. MF
GO:0004125 L-seryl-tRNASec selenium transferase activity Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate. MF
GO:0004124 cysteine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. MF
GO:0004127 cytidylate kinase activity Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. MF
GO:0004126 cytidine deaminase activity Catalysis of the reaction: cytidine + H2O = uridine + NH3. MF
GO:0001571 non-tyrosine kinase fibroblast growth factor receptor activity A receptor belonging to the FGFR family but lacking the tyrosine kinase domain. MF
GO:0001570 vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. BP
GO:0001573 ganglioside metabolic process The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. BP
GO:0001572 lactosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides. BP
GO:0001575 globoside metabolic process The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes. BP
GO:0001574 ganglioside biosynthetic process The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. BP
GO:0018418 nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. BP
GO:0001576 globoside biosynthetic process The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). BP
GO:0001579 medium-chain fatty acid transport The directed movement of medium-chain fatty acids into, out of, within or between cells. Medium-chain fatty acids are fatty acids with a chain length of between 8 and 12 carbons. BP
GO:0001578 microtubule bundle formation A process that results in a parallel arrangement of microtubules. BP
GO:0008847 Enterobacter ribonuclease activity Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. MF
GO:0048653 anther development The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure. BP
GO:0016719 carotene 7,8-desaturase activity Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O. MF
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. MF
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. MF
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. MF
GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. MF
GO:0016711 flavonoid 3'-monooxygenase activity Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. MF
GO:0016710 trans-cinnamate 4-monooxygenase activity Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O. MF
GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. MF
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. MF
GO:0015974 guanosine pentaphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. BP
GO:0015975 energy derivation by oxidation of reduced inorganic compounds NA BP
GO:0015976 carbon utilization NA BP
GO:0015977 carbon utilization by fixation of carbon dioxide The processes by which inorganic carbon (usually carbon dioxide) is incorporated into organic compounds (usually carbohydrates). BP
GO:0015970 guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. BP
GO:0015971 guanosine tetraphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. BP
GO:0015972 guanosine pentaphosphate metabolic process The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. BP
GO:0015973 guanosine pentaphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. BP
GO:0015978 carbon utilization by utilization of organic compounds NA BP
GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. BP
GO:0017194 N-terminal peptidyl-isoleucine acetylation The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed. BP
GO:0017195 N-terminal peptidyl-lysine N2-acetylation The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. BP
GO:0017196 N-terminal peptidyl-methionine acetylation The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine. BP
GO:0017197 N-terminal peptidyl-proline acetylation The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline. BP
GO:0017190 N-terminal peptidyl-aspartic acid acetylation The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase. BP
GO:0017192 N-terminal peptidyl-glutamine acetylation The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable. BP
GO:0017193 N-terminal peptidyl-glycine acetylation The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine. BP
GO:0017198 N-terminal peptidyl-serine acetylation The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine. BP
GO:0017199 N-terminal peptidyl-threonine acetylation The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase. BP
GO:0009207 purine ribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009206 purine ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009205 purine ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009204 deoxyribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009203 ribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009202 deoxyribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009201 ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009200 deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0065003 macromolecule complex assembly The aggregation and bonding together of a set of macromolecules to form a complex. BP
GO:0065002 intracellular protein transport across a membrane The directed movement of proteins in a cell, from one side of a membrane to another. BP
GO:0052388 induction by organism of apoptosis in other organism during symbiotic interaction Any process by which an organism activates programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052389 positive regulation by symbiont of defense-related host calcium ion flux Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0065007 biological regulation Any process that modulates the frequency, rate or extent of any biological process, quality or function. BP
GO:0065006 protein-carbohydrate complex assembly The aggregation and bonding together of proteins and carbohydrates to form a protein-carbohydrate complex. BP
GO:0065005 protein-lipid complex assembly The aggregation and bonding together of proteins and lipids to form a protein-DNA complex. BP
GO:0065004 protein-DNA complex assembly The aggregation and bonding together of proteins and DNA molecules to form a protein-DNA complex. BP
GO:0052382 induction by organism of innate immunity in other organism during symbiotic interaction The activation by an organism of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052380 modulation by symbiont of entry into host via phagocytosis Any process by which an organism modulates the frequency, rate or extent to which it enters into the host, via the phagocytotic processes of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0065008 regulation of biological quality Any process that modulates the frequency, rate or extent of a biological attribute, such as size, mass, shape or color. BP
GO:0052386 cell wall thickening A type of cell wall modification in which the cell wall is reinforced and made thicker. BP
GO:0052385 evasion or tolerance by organism of reactive oxygen species produced by other organism during symbiotic interaction The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051325 interphase Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. BP
GO:0007558 regulation of juvenile hormone secretion Any process that modulates the frequency, rate or extent of juvenile hormone secretion. BP
GO:0051327 M phase of meiotic cell cycle Progression through M phase, the part of the meiotic cell cycle during which meiosis and cytokinesis take place. BP
GO:0008154 actin polymerization and/or depolymerization Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. BP
GO:0008156 negative regulation of DNA replication Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication. BP
GO:0008157 protein phosphatase 1 binding Interacting selectively with the enzyme protein phosphatase 1. MF
GO:0008150 biological_process Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. BP
GO:0008152 metabolic process Processes that cause many of the chemical changes in living organisms, including anabolism and catabolism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. BP
GO:0008153 para-aminobenzoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins. BP
GO:0008158 hedgehog receptor activity Combining with the hedgehog protein to initiate a change in cell activity. MF
GO:0008159 positive transcription elongation factor activity Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. MF
GO:0032375 negative regulation of cholesterol transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells. BP
GO:0032374 regulation of cholesterol transport Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells. BP
GO:0007553 regulation of ecdysteroid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. BP
GO:0032376 positive regulation of cholesterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells. BP
GO:0009715 chalcone biosynthetic process The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives. BP
GO:0015276 ligand-gated ion channel activity NA MF
GO:0045229 external encapsulating structure organization and biogenesis The assembly and arrangement of external structures that lie outside the plasma membrane and surround the entire cell. BP
GO:0045228 slime layer polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall. BP
GO:0045225 negative regulation of CD4 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. BP
GO:0045224 positive regulation of CD4 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. BP
GO:0045227 capsule polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. BP
GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. BP
GO:0045221 negative regulation of FasL biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. BP
GO:0045220 positive regulation of FasL biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. BP
GO:0045223 regulation of CD4 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. BP
GO:0045222 CD4 biosynthetic process The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. BP
GO:0045597 positive regulation of cell differentiation Any process that activates or increases the frequency, rate or extent of cell differentiation. BP
GO:0045596 negative regulation of cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation. BP
GO:0045595 regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features. BP
GO:0045594 positive regulation of cumulus cell differentiation Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation. BP
GO:0045593 negative regulation of cumulus cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of ovarian cumulus cell differentiation. BP
GO:0045592 regulation of cumulus cell differentiation Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation. BP
GO:0045591 positive regulation of regulatory T cell differentiation Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells. BP
GO:0045590 negative regulation of regulatory T cell differentiation Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells. BP
GO:0045599 negative regulation of fat cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of adipocyte differentiation. BP
GO:0045598 regulation of fat cell differentiation Any process that modulates the frequency, rate or extent of adipocyte differentiation. BP
GO:0015105 arsenite transporter activity Enables the directed movement of arsenite into, out of, within or between cells. MF
GO:0015104 antimonite transporter activity Enables the directed movement of antimonite into, out of, within or between cells. MF
GO:0015107 chlorate transporter activity Enables the directed movement of chlorate into, out of, within or between cells. Chlorates are inorganic salts of chloric acid that contain the ClO3- ion. MF
GO:0015106 bicarbonate transporter activity Enables the directed movement of bicarbonate into, out of, within or between cells. Bicarbonate is the hydrogencarbonate ion, HCO3-. MF
GO:0015101 organic cation transporter activity Enables the directed movement of organic cations into, out of, within or between cells. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. MF
GO:0015100 vanadium ion transporter activity Enables the directed movement of vanadium (V) ions into, out of, within or between cells. MF
GO:0015103 inorganic anion transporter activity Enables the directed movement of inorganic anions into, out of, within or between cells. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. MF
GO:0015109 chromate transporter activity Enables the directed movement of chromate into, out of, within or between cells. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3. MF
GO:0015108 chloride transporter activity Enables the directed movement of chloride ions into, out of, within or between cells. MF
GO:0016458 gene silencing Any mechanism, at the level of transcription or post-transcription, causing long-term gene inactivation. BP
GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. CC
GO:0016452 theta DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). MF
GO:0016453 C-acetyltransferase activity Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. MF
GO:0016450 kappa DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). MF
GO:0016451 nu DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). A low fidelity DNA-directed DNA polymerase involved in translesion DNA synthesis. MF
GO:0016456 dosage compensation complex (sensu Insecta) An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). CC
GO:0016457 dosage compensation complex assembly (sensu Insecta) Assembly of the dosage compensation complex on the male X chromosome, as in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). In Drosophila, the complex of MSL1 and MSL2 proteins forms a pre-complex, the addition of MLE proteins and roX2 RNA forms a primary complex and the addition of the MOF and MSL3 proteins and the roX1 RNA forms the mature complex. BP
GO:0016454 C-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. MF
GO:0016455 RNA polymerase II transcription mediator activity Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. MF
GO:0035077 ecdysone-mediated polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation. BP
GO:0035076 ecdysone receptor-mediated signaling pathway The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex. BP
GO:0035075 response to ecdysone A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. BP
GO:0035074 pupation The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period. BP
GO:0035073 pupariation The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis. BP
GO:0035072 ecdysone-mediated induction of salivary gland cell autophagic cell death Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis. BP
GO:0035071 salivary gland cell autophagic cell death The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis. BP
GO:0035070 salivary gland histolysis The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. BP
GO:0035079 polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals. BP
GO:0035078 induction of programmed cell death by ecdysone Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death. BP
GO:0009166 nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). BP
GO:0050271 S-alkylcysteine lyase activity Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate. MF
GO:0009164 nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0043335 protein unfolding The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. BP
GO:0043334 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. MF
GO:0043337 CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin). MF
GO:0043336 site-specific telomere resolvase activity Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases. MF
GO:0043331 response to dsRNA A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. BP
GO:0043330 response to exogenous dsRNA A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus, which is usually indicative of a viral infection. BP
GO:0043333 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. MF
GO:0043332 mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. CC
GO:0050274 salicyl-alcohol beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + salicyl alcohol = UDP + salicin. MF
GO:0043339 establishment and/or maintenance of neuroblast polarity (sensu Nematoda and Protostomia) The specification, formation and maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043338 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol. MF
GO:0050275 scopoletin glucosyltransferase activity Catalysis of the reaction: UDP-glucose + scopoletin = UDP + scopolin. MF
GO:0050277 sedoheptulokinase activity Catalysis of the reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate. MF
GO:0009940 amino-terminal vacuolar sorting propeptide binding Interacting selectively with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin coated vesicles. MF
GO:0009941 chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. CC
GO:0009942 longitudinal axis specification The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root. BP
GO:0009943 adaxial/abaxial axis specification The establishment, maintenance and elaboration of the adaxial (adjacent to the stem) / abaxial (away from the stem) axis in plants. BP
GO:0009944 polarity specification of adaxial/abaxial axis The process resulting in the establishment of polarity along the adaxial/abaxial axis. BP
GO:0009945 radial axis specification The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point. BP
GO:0009946 proximal/distal axis specification The establishment, maintenance and elaboration of the proximal/distal axis. BP
GO:0009947 centrolateral axis specification The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf. BP
GO:0009948 anterior/posterior axis specification The establishment, maintenance and elaboration of the anterior/posterior axis. BP
GO:0009949 polarity specification of anterior/posterior axis The processes resulting in the establishment of polarity along the anterior/posterior axis. BP
GO:0031316 extrinsic to nuclear outer membrane Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region. CC
GO:0031317 tripartite ATP-independent periplasmic transporter complex A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using enery from ion gradients. CC
GO:0031314 extrinsic to mitochondrial inner membrane Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region. CC
GO:0031315 extrinsic to mitochondrial outer membrane Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region. CC
GO:0031312 extrinsic to organelle membrane Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region. CC
GO:0031313 extrinsic to endosome membrane Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region. CC
GO:0031310 intrinsic to vacuolar membrane Located in the vacuolar membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031311 intrinsic to contractile vacuolar membrane Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031318 detection of folic acid The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal. BP
GO:0031319 detection of cAMP The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP. BP
GO:0048408 epidermal growth factor binding Interacting selectively with epidermal growth factor. MF
GO:0048406 nerve growth factor binding Interacting selectively with nerve growth factor. MF
GO:0048407 platelet-derived growth factor binding Interacting selectively with platelet-derived growth factor. MF
GO:0048404 neurotrophin-3 binding Interacting selectively with neurotrophin-3. MF
GO:0048405 neurotrophin-4/5 binding Interacting selectively with neurotrophin-4/5. MF
GO:0048402 intermediate mesoderm structural organization The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048403 brain-derived neurotrophic factor binding Interacting selectively with brain-derived neurotrophic factor. MF
GO:0048400 positive regulation of intermediate mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification. BP
GO:0048401 negative regulation of intermediate mesodermal cell fate specification Any process that stops, prevents or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification. BP
GO:0048759 vessel member cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened. BP
GO:0050438 2-ethylmalate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA . MF
GO:0050439 2-hydroxy-3-oxoadipate synthase activity Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 . MF
GO:0050436 microfibril binding Interacting selectively with a microfibril, any small fibril occurring in biological material. MF
GO:0050437 (-)-endo-fenchol synthase activity Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + (-)-endo-fenchol. MF
GO:0050434 positive regulation of viral transcription Any process that activates or increases the frequency, rate or extent of viral transcription. BP
GO:0050435 beta-amyloid metabolic process The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). BP
GO:0050432 catecholamine secretion The regulated release of catecholamines by a cell or group of cells. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. BP
GO:0050433 regulation of catecholamine secretion Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. BP
GO:0050430 syntaxin-6 binding Interacting selectively with the SNAP receptor syntaxin-6. MF
GO:0050431 transforming growth factor beta binding Interacting selectively with TGFbeta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. MF
GO:0050380 undecaprenyl-diphosphatase activity Catalysis of the reaction: undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. MF
GO:0050381 unspecific monooxygenase activity Catalysis of the reaction: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. MF
GO:0050382 uracil-5-carboxylate decarboxylase activity Catalysis of the reaction: uracil 5-carboxylate = uracil + CO2. MF
GO:0050383 uracil dehydrogenase activity Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor. MF
GO:0050384 urate-ribonucleotide phosphorylase activity Catalysis of the reaction: urate D-ribonucleotide + phosphate = urate + D-ribose 1-phosphate. MF
GO:0050385 ureidoglycolate lyase activity Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea. MF
GO:0050386 ureidosuccinase activity Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O = L-aspartate + CO2 + NH3. MF
GO:0050387 urethanase activity Catalysis of the reaction: urethane + H2O = ethanol + CO2 + NH3. MF
GO:0050388 uronate dehydrogenase activity Catalysis of the reaction: D-galacturonate + NAD+ + H2O = D-galactarate + NADH. MF
GO:0050389 uronolactonase activity Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate. MF
GO:0018889 2-chloro-N-isopropylacetanilide metabolic process The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants. BP
GO:0018888 3-chloroacrylic acid metabolic process The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid. BP
GO:0018887 4-carboxy-4'-sulfoazobenzene metabolic process The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid. BP
GO:0018886 anaerobic carbon tetrachloride metabolic process The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen. BP
GO:0018885 carbon tetrachloride metabolic process The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. BP
GO:0018884 carbazole metabolic process The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. BP
GO:0018883 caprolactam metabolic process The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation. BP
GO:0018882 (+)-camphor metabolic process The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed. BP
GO:0018881 bromoxynil metabolic process The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants. BP
GO:0018880 4-chlorobiphenyl metabolic process The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation. BP
GO:0032036 myosin heavy chain binding Interacting selectively with a heavy chain of a myosin complex. MF
GO:0032037 myosin I heavy chain binding Interacting selectively with a heavy chain of a myosin I complex. MF
GO:0032034 myosin II head/neck binding Interacting selectively with the head/neck region of a myosin II heavy chain. MF
GO:0032035 myosin II tail binding Interacting selectively with the tail region of a myosin II heavy chain. MF
GO:0032032 myosin I tail binding Interacting selectively with the tail region of a myosin I heavy chain. MF
GO:0032033 myosin II light chain binding Interacting selectively with a light chain of a myosin II complex. MF
GO:0032030 myosin I light chain binding Interacting selectively with a light chain of a myosin I complex. MF
GO:0032031 myosin I head/neck binding Interacting selectively with the head/neck region of a myosin I heavy chain. MF
GO:0032038 myosin II heavy chain binding Interacting selectively with a heavy chain of a myosin II complex. MF
GO:0032039 integrator complex A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. CC
GO:0000938 GARP complex A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. CC
GO:0000939 inner kinetochore of condensed chromosome The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. CC
GO:0000936 primary cell septum A cell septum that forms following nuclear division. CC
GO:0000937 dolipore septum A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome). CC
GO:0000934 porous cell septum A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments. CC
GO:0000935 barrier septum A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments. CC
GO:0000932 cytoplasmic mRNA processing body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. CC
GO:0000933 adventitious septum A cell septum whose formation is independent of nuclear division. CC
GO:0000930 gamma-tubulin complex A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. CC
GO:0000931 gamma-tubulin large complex A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. CC
GO:0019826 oxygen sensor activity NA MF
GO:0019827 stem cell maintenance The process by which an organism retains a population of stem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. BP
GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family. BP
GO:0019825 oxygen binding Interacting selectively with oxygen (O2). MF
GO:0019822 P4 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. CC
GO:0019823 P5 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. CC
GO:0019820 P2 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed. CC
GO:0019821 P3 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content. CC
GO:0002422 immune response in urogenital tract An immune response taking place in the urogenital tract. The urogenital tract. BP
GO:0002423 natural killer cell mediated immune response to tumor cell An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell. BP
GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. BP
GO:0002421 B cell antigen processing and presentation following pinocytosis B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. BP
GO:0002426 immunoglobulin production in mucosal tissue The synthesis and release of immunoglobulin in the mucosal tissue. BP
GO:0002427 mucosal tolerance induction Tolerance induction taking place in the mucosal tissues. BP
GO:0019828 aspartic-type endopeptidase inhibitor activity Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. MF
GO:0019829 cation-transporting ATPase activity Catalysis of the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). MF
GO:0048755 branching morphogenesis of a nerve The process by which the anatomical structures of branches in a nerve are generated and organized. Morphogenesis pertains to the creation of form. This term refers to an anatomical structure (nerve) not a cell (neuron). BP
GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. BP
GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. BP
GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006429 leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0000118 histone deacetylase complex Complex that possesses histone deacetylase activity. CC
GO:0000119 mediator complex A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription. CC
GO:0000110 nucleotide-excision repair factor 1 complex One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. CC
GO:0000111 nucleotide-excision repair factor 2 complex One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. CC
GO:0000112 nucleotide-excision repair factor 3 complex One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. CC
GO:0000113 nucleotide-excision repair factor 4 complex One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. CC
GO:0000114 G1-specific transcription in mitotic cell cycle Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle. BP
GO:0000115 S-phase-specific transcription in mitotic cell cycle A cell cycle process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle. BP
GO:0000116 G2-specific transcription in mitotic cell cycle Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle. BP
GO:0000117 G2/M-specific transcription in mitotic cell cycle Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle. BP
GO:0007469 antennal development The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli. BP
GO:0007468 regulation of rhodopsin gene activity Any process that modulates the frequency, rate or extent of rhodopsin gene activity. This includes transcriptional, translational, or posttranslational regulation. BP
GO:0015349 thyroid hormone transporter activity Enables the directed movement of thyroid hormones into, out of, within or between cells. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. MF
GO:0015343 siderophore-iron transporter activity Catalysis of the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). MF
GO:0007460 R8 cell fate commitment The process during which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium. BP
GO:0007463 R2/R5 cell fate commitment The process during which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres. BP
GO:0007462 R1/R6 cell fate commitment The process during which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres. BP
GO:0007465 R7 cell fate commitment The process during which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium. BP
GO:0007464 R3/R4 cell fate commitment The process during which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres. BP
GO:0007467 photoreceptor cell differentiation (sensu Endopterygota) The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, the receptor that responds to light. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007466 cone cell fate commitment (sensu Endopterygota) The process during which the cone cells of the eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0010197 polar nucleus fusion The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized. BP
GO:0010196 nonphotochemical quenching The process to maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage. BP
GO:0010191 mucilage metabolic process The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants. BP
GO:0010190 cytochrome b6f complex assembly Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation and bonding together of its constituents. BP
GO:0010193 response to ozone A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. BP
GO:0010192 mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants. BP
GO:0010199 organ boundary specification between lateral organs and the meristem The process by which boundaries between lateral organs and the meristem is established and maintained. BP
GO:0010198 synergid death Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. BP
GO:0021924 cell proliferation in the external granule layer The multiplication or reproduction of neuroblasts resulting in the rapid expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere. BP
GO:0021925 Purkinje cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. BP
GO:0021926 Golgi cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0021927 deep nuclear neuron precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons. BP
GO:0021920 regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord. BP
GO:0021921 regulation of cell proliferation in dorsal spinal cord The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord. BP
GO:0021922 Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division. BP
GO:0021923 cell proliferation in the hindbrain ventricular zone The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity. BP
GO:0021928 basket cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0021929 stellate cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0051569 regulation of histone H3-K4 methylation Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. BP
GO:0051568 histone H3-K4 methylation The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone. BP
GO:0051567 histone H3-K9 methylation The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone. BP
GO:0051566 anthocyanidin-3-glucoside rhamnosyltransferase activity Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP. MF
GO:0051565 reduction of smooth endoplasmic reticulum calcium ion concentration Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum. BP
GO:0051564 elevation of smooth endoplasmic reticulum calcium ion concentration Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum. BP
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis The regulation of the levels, transport, and metabolism of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings. BP
GO:0051562 reduction of mitochondrial calcium ion concentration Any process that decreases the concentration of calcium ions in mitochondria. BP
GO:0051561 elevation of mitochondrial calcium ion concentration Any process that increases the concentration of calcium ions in mitochondria. BP
GO:0051560 mitochondrial calcium ion homeostasis The regulation of the levels, transport, and metabolism of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. BP
GO:0017105 acyl-CoA delta11-desaturase activity NA MF
GO:0018693 ethylbenzene dehydrogenase activity Catalysis of the reaction: ethylbenzene + H2O + 2 ferricenium = 2 H+ + 2 ferrocene + (S)-1-phenylethanol. MF
GO:0018690 4-methoxybenzoate monooxygenase (O-demethylating) activity Catalysis of the reaction: 4-methoxybenzoate + donor-H2 + O2 = 4-hydroxybenzoate + formaldehyde + acceptor + H2O. MF
GO:0018691 arsenite oxidase activity Catalysis of the reaction: arsenite + 10 H2O = 20 H+ + 8 e- + arsenate. MF
GO:0018697 carbonyl sulfide nitrogenase activity Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = H2S + carbon monoxide. MF
GO:0018694 p-cymene methyl hydroxylase activity Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol. MF
GO:0018695 4-cresol dehydrogenase (hydroxylating) activity Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor. MF
GO:0018698 vinyl chloride reductive dehalogenase activity Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene (ethylene). MF
GO:0018699 trichloroethane reductive dehalogenase activity NA MF
GO:0019123 peptidyl-methionine racemization The racemization of peptidyl-methionine. BP
GO:0019122 peptidyl-D-alanine racemization The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine. BP
GO:0019121 peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan. BP
GO:0019120 hydrolase activity, acting on acid halide bonds, in C-halide compounds Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage. MF
GO:0019126 peptidyl-serine racemization The racemization of peptidyl-serine. BP
GO:0019125 peptidyl-phenylalanine racemization The racemization of peptidyl-phenylalanine. BP
GO:0019124 peptidyl-isoleucine racemization The racemization of peptidyl-isoleucine. BP
GO:0019129 peptidyl-leucine racemization The racemization of peptidyl-leucine. BP
GO:0019128 peptidyl-tryptophan racemization The racemization of peptidyl-tryptophan. BP
GO:0042499 signal peptide peptidase activity Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein. MF
GO:0042498 diacylated lipoprotein binding Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a two acyl groups. MF
GO:0042497 triacylated lipoprotein binding Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a three acyl groups. MF
GO:0042496 detection of diacylated bacterial lipoprotein The series of events in which a diacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are diacylated lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs). BP
GO:0016690 diarylpropane peroxidase activity Catalysis of the reaction: 1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 = veratraldehyde + 1-(3,4-dimethylphenyl)ethane-1,2-diol + 4 H2O. MF
GO:0016691 chloride peroxidase activity Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O. MF
GO:0016692 NADH peroxidase activity Catalysis of the reaction: NADH + H+ + H2O2 = NAD+ + 2 H2O. MF
GO:0016693 secretory plant peroxidase activity NA MF
GO:0016695 oxidoreductase activity, acting on hydrogen as donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor. MF
GO:0016696 oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP. MF
GO:0016697 oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome. MF
GO:0030207 chondroitin sulfate catabolic process The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. BP
GO:0047700 beta-glucoside kinase activity Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose. MF
GO:0030205 dermatan sulfate metabolic process The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. BP
GO:0042494 detection of bacterial lipoprotein The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs). BP
GO:0030203 glycosaminoglycan metabolic process The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties. BP
GO:0030202 heparin metabolic process The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. BP
GO:0030201 heparan sulfate proteoglycan metabolic process The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. BP
GO:0047701 beta-L-arabinosidase activity Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol. MF
GO:0004352 glutamate dehydrogenase activity Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. MF
GO:0015774 polysaccharide transport The directed movement of polysaccharides into, out of, within or between cells. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages. BP
GO:0030209 dermatan sulfate catabolic process The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. BP
GO:0042492 gamma-delta T cell differentiation The process whereby a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. BP
GO:0042237 interleukin-20 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-20. BP
GO:0047703 beta-nitroacrylate reductase activity Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + NADPH. MF
GO:0042491 auditory receptor cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an auditory hair cell. BP
GO:0042236 interleukin-19 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-19. BP
GO:0047704 bile-salt sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. MF
GO:0004351 glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. MF
GO:0042235 interleukin-17 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-17. BP
GO:0015773 raffinose transport The directed movement of raffinose into, out of, within or between cells. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. BP
GO:0042234 interleukin-16 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-16. BP
GO:0052038 modulation by symbiont of host intracellular transport Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0015770 sucrose transport The directed movement of sucrose into, out of, within or between cells. Sucrose is the disaccharide fructofuranosyl-glucopyranoside. BP
GO:0052034 negative regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity NA BP
GO:0052035 positive regulation by symbiont of host inflammatory response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052036 negative regulation by symbiont of host inflammatory response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0015771 trehalose transport The directed movement of trehalose into, out of, within or between cells. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. BP
GO:0052030 induction by symbiont of host apoptosis Any process by which an organism activates programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052031 modulation by symbiont of host defense response Any process by which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052032 modulation by symbiont of host inflammatory response Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity NA BP
GO:0047606 acetone-cyanhydrin lyase activity Catalysis of the reaction: acetone cyanhydrin = cyanide + acetone. MF
GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. BP
GO:0003716 RNA polymerase I transcription termination factor activity Any activity that brings about termination of transcription by RNA polymerase I. MF
GO:0003715 transcription termination factor activity Any activity that brings about termination of transcription. MF
GO:0003714 transcription corepressor activity The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself. MF
GO:0003713 transcription coactivator activity The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself. MF
GO:0006540 glutamate decarboxylation to succinate NA BP
GO:0031154 culmination during fruiting body development The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. This process takes place during fruiting body development in cellular slime molds. The culminant is the structure in which stalk tube formation has progressed down to the basal disc. Terminal cell differentiation occurs at this stage. BP
GO:0031155 regulation of fruiting body development Any process that modulates the frequency, rate or extent of fruiting body development. BP
GO:0031156 regulation of fruiting body development (sensu Dictyosteliida) Any process that modulates the frequency, rate or extent of fruiting body development in cellular slime molds. As in, but not restricted to, the taxon Dictyosteliida (Dictyosteliida, ncbi_taxonomy_id:33083). BP
GO:0008683 2-oxoglutarate decarboxylase activity Catalysis of the reaction: 2-oxoglutarate = succinate semialdehyde + CO2. MF
GO:0031150 stalk development (sensu Dictyosteliida) The process whose specific outcome is the progression of the stalk over time, from its formation to the mature structure. The stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. As in, but not restricted to, the taxon Dictyosteliida (Dictyosteliida, ncbi_taxonomy_id:33083). BP
GO:0031151 histone lysine N-methyltransferase activity (H3-K79 specific) Catalysis of the addition of a methyl group onto lysine at position 79 of the histone H3 protein. MF
GO:0031152 aggregation during fruiting body development The initial phase of fruiting body development in cellular slime molds, in which an aggregate develops by the chemoattractant-mediated movement of cells toward each other. BP
GO:0031153 slug development during fruiting body development The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development takes place during fruiting body development in cellular slime molds. The slug is the migratory structure formed when the finger bends from a vertical position to a horizontal position. BP
GO:0006844 acyl carnitine transport The directed movement of acyl carnitine into, out of, within or between cells. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. BP
GO:0031158 negative regulation of aggregate size Any process that decreases the size of the aggregate formed during fruiting body formation in cellular slime molds. BP
GO:0031159 positive regulation of aggregate size Any process that increases the size of the aggregate formed during fruiting body formation in cellular slime molds. BP
GO:0008864 formyltetrahydrofolate deformylase activity Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. MF
GO:0008865 fructokinase activity Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. MF
GO:0051828 entry into other organism during symbiotic interaction Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051829 entry into other organism through natural portals during symbiotic interaction Penetration by an organism into a second organism via naturally occurring openings in the second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051822 dissemination or transmission of organism from other organism by vector during symbiotic interaction The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal. BP
GO:0051823 regulation of synapse structural plasticity Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane. BP
GO:0051820 induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction The process by which an organism causes the formation in a second organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism, where the two organisms are in a symbiotic interaction. BP
GO:0051821 dissemination or transmission of organism from other organism during symbiotic interaction The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism. BP
GO:0051826 negative regulation of synapse structural plasticity Any process that stops, prevents or reduces the frequency, rate or extent of synapse structural plasticity. BP
GO:0051827 growth or development on or near surface of other organism during symbiotic interaction The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051824 recognition of other organism during symbiotic interaction The specific processes that allow an organism to detect the presence of a second organism via physical or chemical signals, where the two organisms are in a symbiotic interaction. BP
GO:0051825 adhesion to other organism during symbiotic interaction The attachment of an organism to a second organism, where the two organisms are in a symbiotic interaction. Adhesion may be via adhesion molecules, general stickiness etc., and may be either direct or indirect. BP
GO:0009434 flagellum (sensu Eukaryota) A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. BP
GO:0009436 glyoxylate catabolic process The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH. BP
GO:0009437 carnitine metabolic process The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. BP
GO:0009431 flagellar basal body, MS ring (sensu Bacteria) One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009432 SOS response An error-prone process for repairing damaged microbial DNA. BP
GO:0009433 flagellar basal body, C ring (sensu Bacteria) Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009438 methylglyoxal metabolic process The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. BP
GO:0009439 cyanate metabolic process The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid. BP
GO:0046949 acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. BP
GO:0046948 hydroxylysine catabolic process The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. BP
GO:0046945 N-terminal peptidyl-alanine N-carbamoylation The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine. BP
GO:0046944 protein amino acid carbamoylation The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2. BP
GO:0046947 hydroxylysine biosynthetic process The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. BP
GO:0046946 hydroxylysine metabolic process The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases. BP
GO:0046941 azetidine-2-carboxylic acid acetyltransferase activity Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid. MF
GO:0046940 nucleoside monophosphate phosphorylation The process of introducing one or more phosphoric groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. BP
GO:0046943 carboxylic acid transporter activity Enables the directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). MF
GO:0046942 carboxylic acid transport The directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). BP
GO:0008479 queuine tRNA-ribosyltransferase activity Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. MF
GO:0008478 pyridoxal kinase activity Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. MF
GO:0008477 purine nucleosidase activity Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose. MF
GO:0008476 protein-tyrosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. MF
GO:0008475 procollagen-lysine 5-dioxygenase activity Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. MF
GO:0008474 palmitoyl-(protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. MF
GO:0008473 ornithine cyclodeaminase activity Catalysis of the reaction: L-ornithine = L-proline + NH3. MF
GO:0008472 metallocarboxypeptidase D activity Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid. MF
GO:0008471 laccase activity Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. MF
GO:0008470 isovaleryl-CoA dehydrogenase activity Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF. MF
GO:0045412 negative regulation of interleukin-7 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7. BP
GO:0045413 positive regulation of interleukin-7 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7. BP
GO:0045410 positive regulation of interleukin-6 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. BP
GO:0045411 regulation of interleukin-7 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7. BP
GO:0045416 positive regulation of interleukin-8 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. BP
GO:0045417 regulation of interleukin-9 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9. BP
GO:0045414 regulation of interleukin-8 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. BP
GO:0045415 negative regulation of interleukin-8 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. BP
GO:0045418 negative regulation of interleukin-9 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9. BP
GO:0045419 positive regulation of interleukin-9 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9. BP
GO:0047304 2-aminoethylphosphonate-pyruvate transaminase activity Catalysis of the reaction: pyruvate + (2-aminoethyl)phosphonate = L-alanine + phosphonoacetaldehyde. MF
GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity Catalysis of the reaction: pyruvate + (R)-3-amino-2-methylpropanoate = L-alanine + methylmalonate-semialdehyde. MF
GO:0047306 D-methionine-pyruvate transaminase activity Catalysis of the reaction: pyruvate + D-methionine = L-alanine + 2-keto-4-methylthiobutyrate. MF
GO:0047307 diaminobutyrate-pyruvate transaminase activity Catalysis of the reaction: pyruvate + L-2,4-diaminobutanoate = L-aspartate-semialdehyde + L-alanine. MF
GO:0047300 pyridoxamine-pyruvate transaminase activity Catalysis of the reaction: pyruvate + pyridoxamine = L-alanine + pyridoxal. MF
GO:0047301 valine-3-methyl-2-oxovalerate transaminase activity Catalysis of the reaction: 2-keto-3-methyl-valerate + L-valine = L-iso-leucine + 2-keto-isovalerate. MF
GO:0047302 UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose. MF
GO:0047303 glycine-oxaloacetate transaminase activity Catalysis of the reaction: oxaloacetic acid + L-glycine = L-aspartate + glyoxylate. MF
GO:0047308 alanine-oxomalonate transaminase activity Catalysis of the reaction: oxomalonate + L-alanine = aminomalonate + pyruvate. MF
GO:0047309 dihydroxyphenylalanine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-dihydroxy-phenylalanine = L-glutamate + 3,4-dihydroxyphenylpyruvate. MF
GO:0030941 chloroplast targeting sequence binding Interacting selectively with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast. MF
GO:0030942 endoplasmic reticulum signal peptide binding Interacting selectively with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. MF
GO:0030943 mitochondrion targeting sequence binding Interacting selectively with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. MF
GO:0030944 DDEL sequence binding Interacting selectively with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. MF
GO:0030945 protein tyrosine phosphatase activity, via thiol-phosphate intermediate The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. MF
GO:0030946 protein tyrosine phosphatase activity, metal-dependent Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate, by a mechanism that requires metal ions. MF
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. BP
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. BP
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. BP
GO:0050960 detection of temperature stimulus during thermoception The series of events during thermoception in which a sensory temperature stimulus is received by a cell and converted into a molecular signal. BP
GO:0050961 detection of temperature stimulus during sensory perception The series of events in which a sensory temperature stimulus is received by a cell and converted into a molecular signal. BP
GO:0050962 detection of light stimulus during sensory perception The series of events in which a sensory light stimulus is received by a cell and converted into a molecular signal. BP
GO:0050963 detection of electrical stimulus during sensory perception The series of events in which a sensory electrical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050964 detection of electrical stimulus during electroception The series of events during electroception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050965 detection of temperature stimulus during sensory perception of pain The series of events during the perception of pain in which a sensory temperature stimulus is received by a cell and converted into a molecular signal. BP
GO:0050966 detection of mechanical stimulus during sensory perception of pain The series of events during the perception of pain in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050967 detection of electrical stimulus during sensory perception of pain The series of events during the perception of pain in which a sensory electrical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050968 detection of chemical stimulus during sensory perception of pain The series of events during the perception of pain in which a sensory chemical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050969 detection of chemical stimulus during magnetoreception The series of events during magnetoception in which a sensory chemical stimulus is received by a cell and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states. BP
GO:0002749 antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR). BP
GO:0002748 antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR). BP
GO:0002743 negative regulation of cytokine biosynthetic process during immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis during immune response. BP
GO:0002742 regulation of cytokine biosynthetic process during immune response Any process that modulates the frequency, rate, or extent of cytokine biosynthesis during immune response. BP
GO:0002741 positive regulation of cytokine secretion during immune response Any process that activates or increases the frequency, rate, or extent of cytokine secretion during immune response. BP
GO:0002740 negative regulation of cytokine secretion during immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion during immune response. BP
GO:0002747 antigen processing and presentation following phagocytosis Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis. BP
GO:0002746 antigen processing and presentation following pinocytosis Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. BP
GO:0002745 antigen processing and presentation initiated by receptor mediated uptake of antigen Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor. BP
GO:0002744 positive regulation of cytokine biosynthetic process during immune response Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis during immune response. BP
GO:0044455 mitochondrial membrane part Any constituent part of the mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. CC
GO:0044454 nuclear chromosome part Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell. CC
GO:0044457 cell septum part Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. CC
GO:0044456 synapse part The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. CC
GO:0044451 nucleoplasm part Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. CC
GO:0044450 microtubule organizing center part Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. CC
GO:0044453 nuclear membrane part Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. CC
GO:0044452 nucleolar part Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. CC
GO:0044459 plasma membrane part Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. CC
GO:0046169 methanol biosynthetic process The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. BP
GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. BP
GO:0046167 glycerol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol. BP
GO:0046166 glyceraldehyde-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. BP
GO:0046165 alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of alkyl compounds containing a hydroxyl group. BP
GO:0046164 alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of alkyl compounds containing a hydroxyl group. BP
GO:0046163 heme c catabolic process The chemical reactions and pathways resulting in the breakdown of heme c, a derivative of heme found in cytochromes c, b4, and f. BP
GO:0046162 heme c metabolic process The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f. BP
GO:0046161 heme a catabolic process The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3. BP
GO:0046160 heme a metabolic process The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3. BP
GO:0035132 post-embryonic medial fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. BP
GO:0035133 post-embryonic caudal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. BP
GO:0035130 post-embryonic pectoral fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted lateraly and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. BP
GO:0035131 post-embryonic pelvic fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. BP
GO:0035136 forelimb morphogenesis The process by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0035137 hindlimb morphogenesis The process by which the anatomical structures of the hindlimb are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0035134 post-embryonic dorsal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. BP
GO:0035135 post-embryonic anal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. BP
GO:0035138 pectoral fin morphogenesis The process by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted lateraly and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. BP
GO:0035139 pelvic fin morphogenesis The process by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. BP
GO:0043108 pilus retraction The process of withdrawing a pilus back into a cell. BP
GO:0043109 regulation of smoothened activity Any process that modulates the activity of the transmembrane protein Smoothened. BP
GO:0043102 amino acid salvage Any process which produces an amino acid from derivatives of it, without de novo synthesis. BP
GO:0043103 hypoxanthine salvage Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis. BP
GO:0043100 pyrimidine base salvage Any process that generates pyrimidine bases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis. BP
GO:0043101 purine salvage Any process that generates a purine, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. BP
GO:0043106 GTP cyclohydrolase I binding Interacting selectively with the enzyme GTP cyclohydrolase I. MF
GO:0043107 type IV pilus-dependent motility Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility. BP
GO:0043104 positive regulation of GTP cyclohydrolase I activity Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I. BP
GO:0043105 negative regulation of GTP cyclohydrolase I activity Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I. BP
GO:0018758 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid. MF
GO:0048219 inter-Golgi cisterna vesicle-mediated transport The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles. BP
GO:0048217 pectic matrix The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls. CC
GO:0048216 negative regulation of Golgi vesicle fusion to target membrane Any process that stops, prevents or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane. BP
GO:0048215 positive regulation of Golgi vesicle fusion to target membrane Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane. BP
GO:0048214 regulation of Golgi vesicle fusion to target membrane Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane. BP
GO:0048213 Golgi vesicle prefusion complex stabilization The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized. BP
GO:0048212 Golgi vesicle uncoating The process by which Golgi vesicle coat proteins are depolymerized, and released for reuse. BP
GO:0048211 Golgi vesicle docking The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane. BP
GO:0048210 Golgi vesicle fusion to target membrane The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane. BP
GO:0042471 ear morphogenesis The process by which the anatomical structures of the ear are generated and organized. Morphogenesis pertains to the creation of form. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. BP
GO:0004371 glycerone kinase activity Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate. MF
GO:0004372 glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. MF
GO:0042472 inner ear morphogenesis The process by which the anatomical structures of the inner ear are generated and organized. Morphogenesis pertains to the creation of form. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. BP
GO:0042475 odontogenesis (sensu Vertebrata) The process whose specific outcome is the progression of a tooth over time, from its formation to the mature structure. Teeth are the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates, and which usually aid in the prehension and mastication of food. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0042474 middle ear morphogenesis The process by which the anatomical structures of middle ear are generated and organized. Morphogenesis pertains to the creation of form. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). BP
GO:0004376 glycolipid mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. MF
GO:0004377 glycolipid 2-alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage. MF
GO:0004378 glycolipid 3-alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-mannose linkage. MF
GO:0042478 regulation of eye photoreceptor cell development Any process that modulates the frequency, rate or extent of eye photoreceptor development. BP
GO:0008806 carboxymethylenebutenolidase activity Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate. MF
GO:0008807 carboxyvinyl-carboxyphosphonate phosphorylmutase activity Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2. MF
GO:0008804 carbamate kinase activity Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate. MF
GO:0008805 carbon-monoxide oxygenase activity Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561. MF
GO:0008802 betaine-aldehyde dehydrogenase activity Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+. MF
GO:0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = 2 NDP. MF
GO:0008800 beta-lactamase activity Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. MF
GO:0008801 beta-phosphoglucomutase activity Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate. MF
GO:0008808 cardiolipin synthase activity Phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. MF
GO:0008809 carnitine racemase activity Catalysis of the reaction: D-carnitine = L-carnitine. MF
GO:0005010 insulin-like growth factor receptor activity NA MF
GO:0005011 macrophage colony stimulating factor receptor activity Combining with macrophage colony stimulating factor to initiate a change in cell activity. MF
GO:0048806 genitalia development The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. BP
GO:0002049 pyoverdine biosynthetic process The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. BP
GO:0002046 opsin binding Interacting selectively with an opsin, any of a group of hydrophbic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. MF
GO:0002047 phenazine biosynthetic process The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. BP
GO:0018450 myrtenol dehydrogenase activity Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal. MF
GO:0018451 epoxide dehydrogenase activity Catalysis of the reaction: ethene oxide (ethylene oxide) + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA. MF
GO:0018452 5-exo-hydroxycamphor dehydrogenase activity Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane. MF
GO:0018453 2-hydroxytetrahydrofuran dehydrogenase activity Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone. MF
GO:0018454 acetoacetyl-CoA reductase activity Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+. MF
GO:0018455 alcohol dehydrogenase [NAD(P)+] activity Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+. MF
GO:0018456 aryl-alcohol dehydrogenase activity Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+. MF
GO:0018457 perillyl-alcohol dehydrogenase activity Catalysis of the reaction: perillyl alcohol + NAD+ = perillyl aldehyde + NADH + H+. MF
GO:0018458 isopiperitenol dehydrogenase activity Catalysis of the reaction: (-)-trans-isopiperitenol + NAD+ = (-)-isopiperitenone + NADH + H+. MF
GO:0018459 carveol dehydrogenase activity Catalysis of the reaction: (-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+. MF
GO:0019321 pentose metabolic process The chemical reactions and pathways involving a pentose, any aldose with a chain of five carbon atoms in the molecule. BP
GO:0019320 hexose catabolic process The chemical reactions and pathways resulting in the breakdown of hexose, any aldose with a chain of six carbon atoms in the molecule. BP
GO:0019323 pentose catabolic process The chemical reactions and pathways resulting in the formation of pentose, any aldose with a chain of five carbon atoms in the molecule. BP
GO:0019322 pentose biosynthetic process The chemical reactions and pathways resulting in the formation of pentose, any aldose with a chain of five carbon atoms in the molecule. BP
GO:0019325 anaerobic fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen. BP
GO:0019324 L-lyxose metabolic process The chemical reactions and pathways involving L-lyxose, the levorotatory isomer of aldopentose lyxo-pentose, the C-2 epimer of xylose. BP
GO:0019327 oxidation of lead sulfide NA BP
GO:0019326 nitrotoluene metabolic process The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached. BP
GO:0019329 ammonia oxidation NA BP
GO:0019328 anaerobic gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen. BP
GO:0050191 phosphoglycerate kinase (GTP) activity Catalysis of the reaction: GTP + 3-phospho-D-glycerate = GDP + 3-phospho-D-glyceroyl phosphate. MF
GO:0050190 phosphoglucokinase activity Catalysis of the reaction: ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate. MF
GO:0050193 phosphoketolase activity Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. MF
GO:0050192 phosphoglycerate phosphatase activity Catalysis of the reaction: D-glycerate 2-phosphate + H2O = D-glycerate + phosphate. MF
GO:0050195 phosphoribokinase activity Catalysis of the reaction: ATP + D-ribose 5-phosphate = ADP + D-ribose 1,5-bisphosphate. MF
GO:0050194 phosphonoacetaldehyde hydrolase activity Catalysis of the reaction: phosphonoacetaldehyde + H2O = acetaldehyde + phosphate. MF
GO:0050197 phytanate-CoA ligase activity Catalysis of the reaction: ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA. MF
GO:0050196 [phosphorylase] phosphatase activity Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate. MF
GO:0050199 piperidine N-piperoyltransferase activity Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine. MF
GO:0050198 pinosylvin synthase activity Catalysis of the reaction: 3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO2. MF
GO:0007050 cell cycle arrest Any process by which progression through the cell cycle is halted during one of the normal phases (G1, S, G2, M). BP
GO:0007051 spindle organization and biogenesis The formation and maintenance of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. BP
GO:0007052 mitotic spindle organization and biogenesis The cell cycle process whereby the microtubule spindle is formed and maintained during a mitotic cell cycle. BP
GO:0007053 male meiotic spindle assembly (sensu Metazoa) The formation of the spindle during a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0007054 male meiosis I spindle assembly (sensu Metazoa) The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0007055 male meiosis II spindle assembly (sensu Metazoa) The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0007056 female meiotic spindle assembly (sensu Metazoa) The formation of the spindle during a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0007057 female meiosis I spindle assembly (sensu Metazoa) The formation of the spindle during meiosis I of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0007058 female meiosis II spindle assembly (sensu Metazoa) The formation of the spindle during meiosis II of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0007059 chromosome segregation The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. BP
GO:0052139 negative chemotaxis within host The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052138 aerotaxis on or near host The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052135 negative aerotaxis within host The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052134 negative aerotaxis on or near host The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052137 aerotaxis within host The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052136 negative chemotaxis on or near host The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052131 positive aerotaxis The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen. BP
GO:0052130 negative aerotaxis The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen. BP
GO:0052133 positive aerotaxis within host The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052132 positive aerotaxis on or near host The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. BP
GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. BP
GO:0006092 main pathways of carbohydrate metabolic process NA BP
GO:0006091 generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. BP
GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. BP
GO:0006097 glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. BP
GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) in other compounds, including pyruvate. BP
GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. BP
GO:0010229 inflorescence development The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure. BP
GO:0010228 vegetative to reproductive phase transition The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence. BP
GO:0010227 floral organ abscission The controlled shedding of floral organs. BP
GO:0010226 response to lithium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. BP
GO:0010225 response to UV-C A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm. BP
GO:0010224 response to UV-B A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 290 to 320 nm. BP
GO:0010223 secondary shoot formation The process involved in the formation of secondary (or auxiliary) shoots in plants. BP
GO:0010222 stem vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the stem of vascular plants. BP
GO:0010221 negative regulation of vernalization response Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. BP
GO:0010220 positive regulation of vernalization response Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. BP
GO:0005548 phospholipid transporter activity Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. MF
GO:0005549 odorant binding Interacting selectively with an odorant, any substance capable of stimulating the sense of smell. MF
GO:0005540 hyaluronic acid binding Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. MF
GO:0005542 folic acid binding Interacting selectively with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. MF
GO:0005543 phospholipid binding Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. MF
GO:0005544 calcium-dependent phospholipid binding Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. MF
GO:0005545 phosphatidylinositol binding Interacting selectively with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. MF
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding Interacting selectively with phosphatidylinositol-4,5-bisphosphate, a diphosphorylated derivative of phosphatidylinositol. MF
GO:0005547 phosphatidylinositol-3,4,5-triphosphate binding Interacting selectively with phosphatidylinositol-3,4,5-triphosphate, the triphosphorylated derivative of phosphatidylinositol. MF
GO:0000709 meiotic joint molecule formation The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule. These joint molecules contain Holliday junctions on either side of heteroduplex DNA. BP
GO:0000708 meiotic strand invasion The cell cycle process whereby the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis. BP
GO:0000701 purine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. MF
GO:0000700 mismatch base pair DNA N-glycosylase activity Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. MF
GO:0000703 oxidized pyrimidine base lesion DNA N-glycosylase activity Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. MF
GO:0000702 oxidized base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. MF
GO:0000705 achiasmate meiosis I The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata. BP
GO:0000704 pyrimidine dimer DNA N-glycosylase activity Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. MF
GO:0000707 meiotic DNA recombinase assembly During meiosis, the assembly of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA. BP
GO:0000706 meiotic DNA double-strand break processing The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis. BP
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. MF
GO:0004638 phosphoribosylaminoimidazole carboxylase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. MF
GO:0004631 phosphomevalonate kinase activity Catalysis of the reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate. MF
GO:0004630 phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. MF
GO:0004633 phosphopantothenoylcysteine decarboxylase activity Catalysis of the reaction: N-((R)-4-phosphopantothenoyl)-L-cysteine = pantetheine 4'-phosphate + CO2. MF
GO:0004632 phosphopantothenate--cysteine ligase activity Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. MF
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity Catalysis of the reaction: 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. MF
GO:0004634 phosphopyruvate hydratase activity Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. MF
GO:0004637 phosphoribosylamine-glycine ligase activity Catalysis of the reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide. MF
GO:0004636 phosphoribosyl-ATP diphosphatase activity Catalysis of the reaction: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + diphosphate. MF
GO:0018159 peptidyl-methionine oxidation The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone. BP
GO:0018158 protein amino acid oxidation The modification of a protein amino acid by oxidation. BP
GO:0018151 peptide cross-linking via L-histidyl-L-tyrosine The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link. BP
GO:0018150 peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link. BP
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine. BP
GO:0018152 peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link. BP
GO:0018155 peptide cross-linking via sn-(2S,6R)-lanthionine The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione). BP
GO:0018154 peptide cross-linking via (2R,6R)-lanthionine The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine). BP
GO:0018157 peptide cross-linking via an oxazole or thiazole The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018156 peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine). BP
GO:0021883 cell cycle arrest of committed forebrain neuronal progenitor cell The process by which progression through the cell cycle is halted in a cell that has been committed to become a neuron that will reside in the forebrain. BP
GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. BP
GO:0021881 Wnt receptor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain. BP
GO:0021880 Notch signaling pathway involved in forebrain neuron fate commitment The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. BP
GO:0021887 hypothalamus gonadotrophin-releasing hormone neuron fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone. BP
GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter. BP
GO:0021885 forebrain cell migration The orderly movement of cells from one site to another at least one of which is located in the forebrain. BP
GO:0021884 forebrain neuron development The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. BP
GO:0021889 olfactory bulb interneuron differentiation The process whereby a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. BP
GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron development The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell. BP
GO:0051248 negative regulation of protein metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. BP
GO:0051249 regulation of lymphocyte activation Any process that modulates the frequency, rate or extent of lymphocyte activation. BP
GO:0051240 positive regulation of multicellular organismal process Any process that activates or increases the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. BP
GO:0051241 negative regulation of multicellular organismal process Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. BP
GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. BP
GO:0051247 positive regulation of protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. BP
GO:0051245 negative regulation of cellular defense response Any process that stops, prevents, or reduces the rate of the cellular defense response. BP
GO:0016089 aromatic amino acid family biosynthetic process, shikimate pathway The chemical reactions and pathways resulting in the formation of amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan) from carbohydrate precursors, with a requirement for chorismate as well as shikimate. BP
GO:0016081 synaptic vesicle docking during exocytosis The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane. BP
GO:0016080 synaptic vesicle targeting The process by which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. BP
GO:0016082 synaptic vesicle priming The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. BP
GO:0016085 myoinhibitory hormone activity NA MF
GO:0016084 myostimulatory hormone activity NA MF
GO:0016087 ecdysiostatic hormone activity NA MF
GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. BP
GO:0021774 retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. BP
GO:0021777 BMP signaling pathway involved in spinal cord association neuron specification A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate. BP
GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. BP
GO:0021771 lateral geniculate nucleus development The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina. BP
GO:0021770 parahippocampal gyrus development The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex. BP
GO:0021773 striatal medium spiny neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum. BP
GO:0021772 olfactory bulb development The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex. BP
GO:0021779 oligodendrocyte cell fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte. BP
GO:0021778 oligodendrocyte cell fate specification The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. BP
GO:0015682 ferric iron transport The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of, within or between cells. BP
GO:0015683 high affinity ferric iron transport NA BP
GO:0015680 intracellular copper ion transport The directed movement of copper (Cu) ions within a cell. BP
GO:0015686 ferric triacetylfusarinine C transport The directed movement of ferric triacetylfusarinine C into, out of, within or between cells. BP
GO:0015687 ferric-hydroxamate transport The directed movement of ferric-hydroxamate into, out of, within or between cells. BP
GO:0015684 ferrous iron transport The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells. BP
GO:0015685 ferric-enterobactin transport The directed movement of ferric-enterobactin into, out of, within or between cells. BP
GO:0015688 iron chelate transport The directed movement of iron chelates into, out of, within or between cells. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. BP
GO:0015689 molybdate ion transport The directed movement of molybdate (MoO4 2-) ions into, out of, within or between cells. Molybdate is the bivalent anion derived from molybdic acid. BP
GO:0016333 morphogenesis of follicular epithelium The process by which the anatomical structures of a follicular epithelium are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0016332 establishment and/or maintenance of polarity of embryonic epithelium The specification, formation and maintenance of anisotropic intracellular organization of epithelial cells in an embryo. BP
GO:0016331 morphogenesis of embryonic epithelium The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0016330 second mitotic wave (sensu Endopterygota) A discrete cell cycle that occurs during the third instar eye imaginal disc after progression of the morphogenetic furrow. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0016337 cell-cell adhesion The attachment of one cell to another cell via adhesion molecules. BP
GO:0046368 GDP-L-fucose metabolic process The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. BP
GO:0016335 morphogenesis of larval imaginal disc epithelium The process by which the anatomical structures of a larval imaginal disc epithelium are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0016334 establishment and/or maintenance of polarity of follicular epithelium The specification, formation and maintenance of a polarized follicular epithelial sheet. BP
GO:0046365 monosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. BP
GO:0046364 monosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. BP
GO:0016339 calcium-dependent cell-cell adhesion The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. BP
GO:0016338 calcium-independent cell-cell adhesion The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. BP
GO:0046361 2-oxobutyrate metabolic process The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. BP
GO:0046360 2-oxobutyrate biosynthetic process The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. BP
GO:0046363 ribitol catabolic process The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. BP
GO:0046362 ribitol biosynthetic process The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. BP
GO:0030435 sporulation The formation of spores. BP
GO:0030436 sporulation (sensu Bacteria) The formation of spores as in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0030437 sporulation (sensu Fungi) The formation of spores as in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0030430 host cell cytoplasm The cytoplasm of a host cell. CC
GO:0030431 sleep The processes by which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. BP
GO:0030432 peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. BP
GO:0030433 ER-associated protein catabolic process The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. BP
GO:0018483 6-oxohexanoate dehydrogenase activity Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+. MF
GO:0018481 4-hydroxymuconic-semialdehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + H+. MF
GO:0018487 vanillate O-demethylase (anaerobic) activity Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate. MF
GO:0008635 caspase activation via cytochrome c Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c. BP
GO:0045299 otolith mineralization The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear. BP
GO:0008637 apoptotic mitochondrial changes The morphological and physiological alterations undergone by mitochondria during apoptosis. BP
GO:0045184 establishment of protein localization The directed movement of a protein to a specific location. BP
GO:0045185 maintenance of protein localization The processes by which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. BP
GO:0047979 hexose oxidase activity Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2. MF
GO:0043606 formamide metabolic process The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid. BP
GO:0045180 basal cortex The region that lies just beneath the plasma membrane on the basal edge of a cell. CC
GO:0045181 glutamate synthase activity, NADH or NADPH as acceptor Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. MF
GO:0045182 translation regulator activity Any substance involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. MF
GO:0045183 translation factor activity, non-nucleic acid binding Any of a group of soluble proteins involved in polypeptide synthesis at the ribosome which do not bind to nucleic acids. MF
GO:0047973 guanidinoacetate kinase activity Catalysis of the reaction: ATP + guanidinoacetate = ADP + phosphoguanidinoacetate. MF
GO:0047972 guanidinopropionase activity Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea. MF
GO:0047971 guanidinobutyrase activity Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea. MF
GO:0047970 guanidinoacetase activity Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea. MF
GO:0047977 hepoxilin-epoxide hydrolase activity Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. MF
GO:0047976 hamamelose kinase activity Catalysis of the reaction: ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate. MF
GO:0047975 guanosine phosphorylase activity Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate. MF
GO:0047974 guanosine deaminase activity Catalysis of the reaction: guanosine + H2O = xanthosine + NH3. MF
GO:0008633 activation of pro-apoptotic gene products The conversion of proteins that induce or sustain apoptosis to an active form. BP
GO:0008632 apoptotic program The intracellular signaling cascade that results when a cell is triggered to undergo apoptosis. BP
GO:0008639 small protein conjugating enzyme activity Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin-like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. MF
GO:0045295 gamma-catenin binding Interacting selectively with the gamma subunit of the catenin complex. MF
GO:0031479 myosin IX complex A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins. CC
GO:0031478 myosin VIII complex A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain. CC
GO:0031477 myosin VII complex A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain. CC
GO:0031476 myosin VI complex A myosin complex containing a dimer of class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. CC
GO:0031475 myosin V complex A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localisation and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region. CC
GO:0031474 myosin IV complex A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV. CC
GO:0031473 myosin III binding Interacting selectively with a class III myosin; myosin III is monomeric and has an N terminal kinase domain. MF
GO:0031472 propanediol degradation polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase. CC
GO:0031471 ethanolamine degradation polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase. CC
GO:0031470 carboxysome An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions. CC
GO:0042958 maltodextrin transporter activity Enables the directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of, within or between cells. MF
GO:0019577 aldaric acid metabolic process The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. BP
GO:0009665 plastid inheritance The partitioning of plastids between daughter cells at cell division. BP
GO:0044274 organismal biosynthetic process The chemical reactions and pathways resulting in the formation of substances in multicellular organisms, occurring at the tissue, organ, or organismal level. BP
GO:0009667 plastid inner membrane organization and biogenesis The assembly and arrangement of the inner membrane of a plastid. BP
GO:0044276 organismal carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms occurring at the tissue, organ, or organismal level. BP
GO:0009661 chromoplast organization and biogenesis The assembly and arrangement of the chromoplast. BP
GO:0009660 amyloplast organization and biogenesis The assembly and arrangement of an amyloplast. BP
GO:0044273 sulfur compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. BP
GO:0044272 sulfur compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. BP
GO:0042956 maltodextrin transport The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of, within or between cells. BP
GO:0009669 sucrose permease activity Catalysis of the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in). MF
GO:0009668 plastid membrane organization and biogenesis The assembly and arrangement of the membrane of a plastid. BP
GO:0042957 dextrin transporter activity Enables the directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of, within or between cells. MF
GO:0008398 sterol 14-demethylase activity Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O. MF
GO:0008399 naphthalene hydroxylase activity NA MF
GO:0008396 oxysterol 7-alpha-hydroxylase activity Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. MF
GO:0008397 sterol 12-alpha-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. MF
GO:0008394 olfactory-specific steroid hydroxylase activity NA MF
GO:0008395 steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. MF
GO:0008392 arachidonic acid epoxygenase activity NA MF
GO:0008393 fatty acid (omega-1)-hydroxylase activity NA MF
GO:0008390 testosterone 16-alpha-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O. MF
GO:0008391 arachidonic acid monooxygenase activity NA MF
GO:0008538 proteasome activator activity Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis. MF
GO:0008539 proteasome inhibitor activity NA MF
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. MF
GO:0008533 astacin activity Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'. MF
GO:0008531 riboflavin kinase activity Catalysis of the reaction: ATP + riboflavin = ADP + FMN. MF
GO:0008536 Ran GTPase binding Interacting selectively with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. MF
GO:0008537 proteasome activator complex A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex. CC
GO:0008534 oxidized purine base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. MF
GO:0008535 cytochrome c oxidase complex assembly The aggregation and bonding together of a set of components to form cytochrome c oxidase, the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. BP
GO:0045603 positive regulation of endothelial cell differentiation Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. BP
GO:0045602 negative regulation of endothelial cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell differentiation. BP
GO:0045601 regulation of endothelial cell differentiation Any process that modulates the frequency, rate or extent of endothelial cell differentiation. BP
GO:0045600 positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. BP
GO:0045607 regulation of auditory receptor cell differentiation Any process that modulates the frequency, rate or extent of auditory hair cell differentiation. BP
GO:0045606 positive regulation of epidermal cell differentiation Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. BP
GO:0045605 negative regulation of epidermal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of epidermal cell differentiation. BP
GO:0045604 regulation of epidermal cell differentiation Any process that modulates the frequency, rate or extent of epidermal cell differentiation. BP
GO:0045609 positive regulation of auditory receptor cell differentiation Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation. BP
GO:0045608 negative regulation of auditory receptor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of auditory hair cell differentiation. BP
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. MF
GO:0047114 kynurenate-7,8-dihydrodiol dehydrogenase activity Catalysis of the reaction: NAD+ + 7,8-dihydro-7,8-dihydroxykynurenate = NADH + 7,8-dihydroxykynurenate. MF
GO:0047117 enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+. MF
GO:0047116 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol. MF
GO:0047111 formate dehydrogenase (cytochrome-c-553) activity Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. MF
GO:0047110 phenylglyoxylate dehydrogenase (acylating) activity Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = NADH + CO2 + benzoyl-S-CoA. MF
GO:0047113 aldehyde dehydrogenase (pyrroloquinoline-quinone) activity Catalysis of the reaction: H2O + acceptor + an aldehyde = donor-H2 + an acid. MF
GO:0047112 pyruvate oxidase activity Catalysis of the reaction: O2 + phosphate + pyruvate = H2O2 + CO2 + acetylphosphate. MF
GO:0047119 2-methyl-branched-chain-enoyl-CoA reductase activity Catalysis of the reaction: NAD+ + 2-methylbutyryl-CoA = NADH + 2-methylcrotonoyl-CoA. MF
GO:0047118 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity Catalysis of the reaction: NADP+ + 2,6-dioxo-6-phenylhexanoate = NADPH + 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate. MF
GO:0031806 metabotropic histamine receptor binding Interacting selectively with a metabotropic histamine receptor. MF
GO:0031807 H1 histamine receptor binding Interacting selectively with a H1 histamine receptor. MF
GO:0031804 type 7 metabotropic glutamate receptor binding Interacting selectively with a type 7 metabotropic glutamate receptor. MF
GO:0031805 type 8 metabotropic glutamate receptor binding Interacting selectively with a type 8 metabotropic glutamate receptor. MF
GO:0031802 type 5 metabotropic glutamate receptor binding Interacting selectively with a type 5 metabotropic glutamate receptor. MF
GO:0031803 type 6 metabotropic glutamate receptor binding Interacting selectively with a type 6 metabotropic glutamate receptor. MF
GO:0031800 type 3 metabotropic glutamate receptor binding Interacting selectively with a type 3 metabotropic glutamate receptor. MF
GO:0031801 type 4 metabotropic glutamate receptor binding Interacting selectively with a type 4 metabotropic glutamate receptor. MF
GO:0031808 H2 histamine receptor binding Interacting selectively with a H2 histamine receptor. MF
GO:0031809 H3 histamine receptor binding Interacting selectively with a H3 histamine receptor. MF
GO:0046648 positive regulation of gamma-delta T cell proliferation Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation. BP
GO:0046649 lymphocyte activation A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0046642 negative regulation of alpha-beta T cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell proliferation. BP
GO:0046643 regulation of gamma-delta T cell activation Any process that modulates the frequency, rate or extent of gamma-delta T cell activation. BP
GO:0046640 regulation of alpha-beta T cell proliferation Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. BP
GO:0046641 positive regulation of alpha-beta T cell proliferation Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. BP
GO:0046646 regulation of gamma-delta T cell proliferation Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation. BP
GO:0046647 negative regulation of gamma-delta T cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell proliferation. BP
GO:0046644 negative regulation of gamma-delta T cell activation Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation. BP
GO:0046645 positive regulation of gamma-delta T cell activation Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation. BP
GO:0005706 polytene chromosome ectopic fiber A thread-like connection joining two regions of ectopically paired polytene chromosomes. CC
GO:0005704 polytene chromosome band A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band. CC
GO:0005705 polytene chromosome interband A stretch of less tightly packed chromatin along the polytene chromosome, found between bands. CC
GO:0005702 polytene chromosome weak point A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization. CC
GO:0005703 polytene chromosome puff A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription. CC
GO:0005700 polytene chromosome A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible. CC
GO:0005701 polytene chromosome chromocenter A region at which the centric regions of polytene chromosomes are joined together. CC
GO:0007630 jump response The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus. BP
GO:0007631 feeding behavior Behavior associated with the intake of food. BP
GO:0007632 visual behavior The actions or reactions of an organism in response to a visual stimulus. BP
GO:0007633 pattern orientation The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes. BP
GO:0007634 optokinetic behavior The actions or reactions of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus. BP
GO:0007635 chemosensory behavior Behavior that is dependent upon the sensation of chemicals. BP
GO:0007636 chemosensory jump behavior The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance. BP
GO:0007637 proboscis extension reflex The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus. BP
GO:0007638 mechanosensory behavior Behavior that is dependent upon the sensation of a mechanical stimulus. BP
GO:0007639 homeostasis of number of meristem cells The biological processes involved in the maintenance of the equilibrium of cell number within a population of cells in the meristem. BP
GO:0002282 microglial cell activation during immune response The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002283 neutrophil activation during immune response The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002280 monocyte activation during immune response The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002281 macrophage activation during immune response A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002286 T cell activation during immune response The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. BP
GO:0002287 alpha-beta T cell activation during immune response The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. BP
GO:0002284 myeloid dendritic cell differentiation during immune response The process whereby an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell during an immune response. BP
GO:0002285 lymphocyte activation during immune response A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002288 NK T cell activation during immune response The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. BP
GO:0002289 NK T cell proliferation during immune response The expansion of a NK T cell population by cell division during an immune response. BP
GO:0048398 intermediate mesodermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0048399 regulation of intermediate mesodermal cell fate specification Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification. BP
GO:0048392 intermediate mesodermal cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell. BP
GO:0048393 intermediate mesodermal cell fate commitment The process by which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell. BP
GO:0048390 intermediate mesoderm morphogenesis The process by which the anatomical structures of the intermediate mesoderm are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048391 intermediate mesoderm formation The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. BP
GO:0048396 negative regulation of intermediate mesodermal cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination. BP
GO:0048397 positive regulation of intermediate mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination. BP
GO:0048394 intermediate mesodermal cell fate determination Process by which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0048395 regulation of intermediate mesodermal cell fate determination Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination. BP
GO:0018799 4-hydroxybenzoate decarboxylase activity Catalysis of the reaction: 4-hydroxybenzoate = phenol + CO2. MF
GO:0018798 gallate decarboxylase activity Catalysis of the reaction: 3,4,5-trihydroxybenzoate = pyrogallol + CO2. MF
GO:0018796 4,5-dihydroxyphthalate decarboxylase activity Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. MF
GO:0018795 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate. MF
GO:0018794 2-hydroxyisobutyrate decarboxylase activity Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol. MF
GO:0018793 3,5-dibromo-4-hydroxybenzoate decarboxylase activity Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol. MF
GO:0018792 bis(4-chlorophenyl)acetate decarboxylase activity Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM. MF
GO:0018791 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate. MF
GO:0018790 2,3-dihydroxybenzoate decarboxylase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = CO2 + catechol. MF
GO:0006941 striated muscle contraction A process leading to shortening and/or development of tension in striated muscle tissue. BP
GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. BP
GO:0006942 regulation of striated muscle contraction Any process that modulates the frequency, rate or extent of striated muscle contraction. BP
GO:0048028 galacturonan binding Interacting selectively with any simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins. MF
GO:0006944 membrane fusion The joining of two lipid bilayers to form a single membrane. BP
GO:0006949 syncytium formation The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. BP
GO:0048025 negative regulation of nuclear mRNA splicing, via spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing. BP
GO:0048026 positive regulation of nuclear mRNA splicing, via spliceosome Any process that activates or increases the rate or extent of mRNA splicing. BP
GO:0048027 mRNA 5'-UTR binding Interacting selectively with the 5' untranslated region of an mRNA molecule. MF
GO:0048020 CCR chemokine receptor binding Interacting selectively with a CCR chemokine receptor. MF
GO:0048021 regulation of melanin biosynthetic process Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin. BP
GO:0048022 negative regulation of melanin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin. BP
GO:0048023 positive regulation of melanin biosynthetic process Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin. BP
GO:0021579 medulla oblongata morphogenesis The process by which the anatomical structure of the medulla oblongata is generated and organized. Morphogenesis pertains to the creation of form. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. BP
GO:0021578 hindbrain maturation A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. BP
GO:0021573 rhombomere 7 development The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021572 rhombomere 6 development The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021571 rhombomere 5 development The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021570 rhombomere 4 development The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021577 hindbrain structural organization The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. BP
GO:0021576 hindbrain formation The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. BP
GO:0021575 hindbrain morphogenesis The process by which the anatomical structure of the hindbrain is generated and organized. Morphogenesis pertains to the creation of form. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. BP
GO:0021574 rhombomere 8 development The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0050018 L-amino-acid dehydrogenase activity Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH. MF
GO:0050019 L-arabinitol 4-dehydrogenase activity Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + NADH. MF
GO:0050014 ketotetrose-phosphate aldolase activity Catalysis of the reaction: erythrulose 1-phosphate = glycerone phosphate + formaldehyde. MF
GO:0050015 kievitone hydratase activity Catalysis of the reaction: kievitone hydrate = kievitone + H2O. MF
GO:0050016 kynurenine 7,8-hydroxylase activity Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor. MF
GO:0050017 L-3-cyanoalanine synthase activity Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine. MF
GO:0050010 isovitexin beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + isovitexin = isovitexin 2''-O-beta-D-glucoside + UDP. MF
GO:0050011 itaconyl-CoA hydratase activity Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O. MF
GO:0050012 juglone 3-monooxygenase activity Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + donor-H2 + O2 = 3,5-dihydroxy-1,4-naphthoquinone + acceptor + H2O. MF
GO:0050013 2-dehydropantoate aldolase activity Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde. MF
GO:0002918 negative regulation of peripheral B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy. BP
GO:0002919 positive regulation of peripheral B cell anergy Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy. BP
GO:0002912 negative regulation of lymphocyte anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy. BP
GO:0002913 positive regulation of lymphocyte anergy Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy. BP
GO:0002910 positive regulation of peripheral B cell deletion Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion. BP
GO:0002911 regulation of lymphocyte anergy Any process that modulates the frequency, rate, or extent of lymphocyte anergy. BP
GO:0002916 positive regulation of central B cell anergy Any process that activates or increases the frequency, rate, or extent of central B cell anergy. BP
GO:0002917 regulation of peripheral B cell anergy Any process that modulates the frequency, rate, or extent of peripheral B cell anergy. BP
GO:0002914 regulation of central B cell anergy Any process that modulates the frequency, rate, or extent of central B cell anergy. BP
GO:0002915 negative regulation of central B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy. BP
GO:0007399 nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. BP
GO:0007398 ectoderm development The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. BP
GO:0007396 suture of dorsal opening Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole. BP
GO:0007395 dorsal closure, spreading of leading edge cells Dorsally-directed movement of the cells at the leading edge of the epithelium over the amnioserosa. BP
GO:0007394 dorsal closure, elongation of leading edge cells The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis. BP
GO:0007393 dorsal closure, leading edge cell fate determination Process by which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0007392 initiation of dorsal closure Events that occur at the start of dorsal closure. BP
GO:0007391 dorsal closure The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. BP
GO:0007390 germ-band shortening The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo. BP
GO:0051659 maintenance of mitochondrion localization The processes by which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051658 maintenance of nucleus localization The processes by which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051655 maintenance of vesicle localization The processes by which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051654 establishment of mitochondrion localization The directed movement of the mitochondrion to a specific location. BP
GO:0051657 maintenance of organelle localization The processes by which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051656 establishment of organelle localization The directed movement of an organelle to a specific location. BP
GO:0051651 maintenance of cellular localization The processes by which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. BP
GO:0051650 establishment of vesicle localization The directed movement of a vesicle to a specific location. BP
GO:0051653 spindle localization The processes by which is the spindle is transported to, and/or maintained in, a specific location. BP
GO:0051652 maintenance of chromosome localization The processes by which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0052302 modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052303 modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052300 modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052301 modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052306 modulation by organism of innate immunity in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052307 modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of calcium-dependent protein kinase signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052304 modulation by organism of phytoalexin production in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052305 positive regulation by organism of innate immunity in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052308 pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction NA BP
GO:0052309 negative regulation by organism of innate immunity in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0006116 NADH oxidation Any of the processes that result in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD. BP
GO:0006117 acetaldehyde metabolic process The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. BP
GO:0006114 glycerol biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. BP
GO:0006115 ethanol biosynthetic process The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. BP
GO:0006112 energy reserve metabolic process NA BP
GO:0006113 fermentation The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP). BP
GO:0006110 regulation of glycolysis Any process that modulates the frequency, rate or extent of glycolysis. BP
GO:0006111 regulation of gluconeogenesis Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. BP
GO:0006118 electron transport The transport of electrons from an electron donor to an electron acceptor. BP
GO:0006119 oxidative phosphorylation The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. BP
GO:0051497 negative regulation of stress fiber formation Any process that stops, prevents or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. BP
GO:0051496 positive regulation of stress fiber formation Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. BP
GO:0051495 positive regulation of cytoskeleton organization and biogenesis Any process that activates or increases the frequency, rate or extent of the assembly and arrangement of cytoskeletal structures. BP
GO:0051493 regulation of cytoskeleton organization and biogenesis Any process that modulates the frequency, rate or extent of the assembly and arrangement of cytoskeletal structures. BP
GO:0051492 regulation of stress fiber formation Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. BP
GO:0005832 chaperonin-containing T-complex A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. CC
GO:0051490 negative regulation of filopodium formation Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. BP
GO:0015549 carbonyl cyanide m-chlorophenylhydrazone transporter activity Enables the directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of, within or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. MF
GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. BP
GO:0007228 activation of hh target transcription factor Upregulation of the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited. BP
GO:0015189 L-lysine transporter activity Enables the directed movement of L-lysine, 2,6-diaminohexanoic acid, into, out of, within or between cells. MF
GO:0015188 L-isoleucine transporter activity Enables the directed movement of L-isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of, within or between cells. MF
GO:0015185 L-gamma-aminobutyric acid transporter activity Enables the directed movement of L-gamma-aminobutyric acid (4-aminobutyrate, GABA) into, out of, within or between cells. MF
GO:0015184 L-cystine transporter activity Enables the directed movement of L-cystine (also known as dicysteine) into, out of, within or between cells. MF
GO:0015187 glycine transporter activity Enables the directed movement of glycine, aminoethanoic acid, into, out of, within or between cells. MF
GO:0015186 L-glutamine transporter activity Enables the directed movement of L-glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of, within or between cells. MF
GO:0015181 L-arginine transporter activity Enables the directed movement of L-arginine, 2-amino-5-guanidinopentanoic acid, into, out of, within or between cells. MF
GO:0015180 L-alanine transporter activity Enables the directed movement of L-alanine, the levorotatory isomer of 2-aminopropanoic acid, into, out of, within or between cells. MF
GO:0015183 L-aspartate transporter activity Enables the directed movement of L-aspartate, the anion derived from aspartic acid, into, out of, within or between cells. MF
GO:0015182 L-asparagine transporter activity Enables the directed movement of L-asparagine, alpha-aminosuccinamic acid, into, out of, within or between cells. MF
GO:0016988 transcription initiation factor antagonist activity NA MF
GO:0016989 sigma factor antagonist activity NA MF
GO:0016980 creatinase activity Catalysis of the reaction: creatine + H2O = sarcosine + urea. MF
GO:0016983 cytokine beta-glucosidase activity NA MF
GO:0016984 ribulose-bisphosphate carboxylase activity Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. MF
GO:0016985 mannan endo-1,4-beta-mannosidase activity Catalysis of the random hydrolysis of 1,4-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans. MF
GO:0016986 transcription initiation factor activity NA MF
GO:0016987 sigma factor activity A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. MF
GO:0002678 positive regulation of chronic inflammatory response Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response. BP
GO:0015729 oxaloacetate transport The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of, within or between cells. BP
GO:0015728 mevalonate transport The directed movement of mevalonate into, out of, within or between cells. BP
GO:0047759 butanal dehydrogenase activity Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+. MF
GO:0047758 branched-chain fatty acid kinase activity Catalysis of the reaction: ATP + 2-methylpropanoate = ADP + 2-methylpropanoyl phosphate. MF
GO:0047753 choline-sulfatase activity Catalysis of the reaction: choline sulfate + H2O = choline + sulfate. MF
GO:0015720 allantoin transport The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of, within or between cells. BP
GO:0015723 bilirubin transport The directed movement of bilirubin into, out of, within or between cells. BP
GO:0015722 canalicular bile acid transport NA BP
GO:0047757 chondroitin-glucuronate 5-epimerase activity Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate. MF
GO:0047756 chondroitin 4-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate. MF
GO:0047755 isocitrate epimerase activity Catalysis of the reaction: (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate = (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate. MF
GO:0047754 choline sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate. MF
GO:0043449 alkene metabolic process The chemical reactions and pathways involving an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond. BP
GO:0043448 alkane catabolic process The chemical reactions and pathways resulting in the breakdown of an alkane, any saturated hydrocarbon without cycles. BP
GO:0043443 acetone metabolic process The chemical reactions and pathways involving acetone, propan-2-one. BP
GO:0043442 acetoacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. BP
GO:0043441 acetoacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. BP
GO:0043440 butanoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of any butanoic acid, 4-carbon saturated monocarboxylic acids. BP
GO:0043447 alkane biosynthetic process The chemical reactions and pathways resulting in the formation of an alkane, any saturated hydrocarbon without cycles. BP
GO:0043446 alkane metabolic process The chemical reactions and pathways involving an alkane, any saturated hydrocarbon without cycles. BP
GO:0043445 acetone biosynthetic process The chemical reactions and pathways resulting in the formation of acetone, propan-2-one. BP
GO:0043444 acetone catabolic process The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one. BP
GO:0046729 viral procapsid A stable empty viral capsid produced during the assembly of viruses. CC
GO:0002676 regulation of chronic inflammatory response Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. BP
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II The process by which an antigen-presenting cell expresses an peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. BP
GO:0002494 lipid antigen transport The directed movement of a lipid antigen into, out of, within or between cells. BP
GO:0046512 sphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. BP
GO:0046088 cytidine biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside. BP
GO:0046089 cytosine biosynthetic process The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. BP
GO:0046080 dUTP metabolic process The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate. BP
GO:0046081 dUTP catabolic process The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. BP
GO:0046082 5-methylcytosine biosynthetic process The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA. BP
GO:0046513 ceramide biosynthetic process The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. BP
GO:0046084 adenine biosynthetic process The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. BP
GO:0046085 adenosine metabolic process The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. BP
GO:0046086 adenosine biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. BP
GO:0046087 cytidine metabolic process The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside. BP
GO:0020031 polar ring of apical complex Electron dense ring at the most anterior position of an invasive life cycle stage of an apicomplexan parasite. CC
GO:0020030 infected host cell surface knob Protrusion that develops in the plasma membrane of a parasitized erythrocyte. CC
GO:0020033 antigenic variation Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system. BP
GO:0020032 basal ring of apical complex NA CC
GO:0020035 cytoadherence to microvasculature, mediated by parasite protein The adherence of parasite-infected erythrocytes to microvascular endothelium via parasite proteins embedded in the membrane of the erythrocyte. BP
GO:0020037 heme binding Interacting selectively with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. MF
GO:0020036 Maurer's cleft NA CC
GO:0020039 pellicle The cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles. CC
GO:0020038 subpellicular network A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton. CC
GO:0030665 clathrin coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle. CC
GO:0030667 secretory granule membrane The lipid bilayer surrounding a secretory granule. CC
GO:0030666 endocytic vesicle membrane The lipid bilayer surrounding an endocytic vesicle. CC
GO:0030661 chitosome membrane The lipid bilayer surrounding a chitosome. CC
GO:0030660 Golgi-associated vesicle membrane The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. CC
GO:0030663 COPI coated vesicle membrane The lipid bilayer surrounding a COPI-coated vesicle. CC
GO:0030662 coated vesicle membrane The lipid bilayer surrounding a coated vesicle. CC
GO:0030669 clathrin-coated endocytic vesicle membrane The lipid bilayer surrounding a clathrin-coated endocytic vesicle. CC
GO:0030668 dense granule membrane (sensu Apicomplexa) The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites. As in, but not restricted to, the apicomplexans (Apicomplexa, ncbi_taxonomy_id:5794). CC
GO:0031398 positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin moieties to a protein. BP
GO:0031399 regulation of protein modification Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. BP
GO:0031396 regulation of protein ubiquitination Any process that modulates the frequency, rate or extent of the addition of ubiquitin moieties to a protein. BP
GO:0031397 negative regulation of protein ubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein. BP
GO:0031394 positive regulation of prostaglandin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. BP
GO:0031395 bursicon neuropeptide hormone complex A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits. CC
GO:0031392 regulation of prostaglandin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. BP
GO:0031393 negative regulation of prostaglandin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. BP
GO:0031390 Ctf18 RFC-like complex A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. CC
GO:0031391 Elg1 RFC-like complex A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. CC
GO:0045063 T-helper 1 cell differentiation The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell. BP
GO:0045062 extrathymic T cell selection The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus. BP
GO:0045061 thymic T cell selection The process of T cell selection that occurs in the thymus. BP
GO:0045060 negative thymic T cell selection The process of elimination of immature T cells in the thymus which react strongly with self-antigens. BP
GO:0045067 positive extrathymic T cell selection The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. BP
GO:0045066 regulatory T cell differentiation The process by which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. BP
GO:0045065 cytotoxic T cell differentiation The process whereby a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell. BP
GO:0045064 T-helper 2 cell differentiation The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell. BP
GO:0045069 regulation of viral genome replication Any process that modulates the frequency, rate or extent of viral genome replication. BP
GO:0045068 negative extrathymic T cell selection The process of elimination of extrathymically maturing T cells which react strongly with self-antigens. BP
GO:0035006 melanization defense response The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin. BP
GO:0035007 regulation of melanization defense response Any process that affects the rate, extent or location of the melanization defense response during injury or invasion. BP
GO:0018807 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA. MF
GO:0055016 hypochord development The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta. BP
GO:0018805 benzylsuccinate synthase activity Catalysis of the reaction: fumarate + toluene = benzylsuccinate. MF
GO:0055014 atrial cardiac muscle cell development The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that allows blood to return to the organ. BP
GO:0018803 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate. MF
GO:0018802 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. MF
GO:0018801 glutaconyl-CoA decarboxylase activity Catalysis of the reaction: pent-2-enoyl-CoA = but-2-enoyl-CoA + CO2. MF
GO:0018800 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. MF
GO:0018809 E-phenylitaconyl-CoA hydratase activity Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA. MF
GO:0018808 cis-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity Catalysis of the reaction: cis-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde. MF
GO:0035008 positive regulation of melanization defense response Any process that increases the rate or extent of the melanization defense response during injury or invasion. BP
GO:0031538 negative regulation of anthocyanin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. BP
GO:0031539 positive regulation of anthocyanin metabolic process Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. BP
GO:0031532 actin cytoskeleton reorganization Dynamic structural changes to the assembly and arrangement of the actin cytoskeleton, comprising actin filaments and their associated proteins. BP
GO:0031533 mRNA capping enzyme complex A protein complex that possesses RNA (guanine-N7) methyltransferase activity and carries out mRNA capping. The fungal mRNA capping apparatus consists of three subunits, a RNA 5' triphosphatase RNA guanyl transferase and mRNA (guanine-N7) methyltransferase activities (Cet1p, Ceg1, and Abd1p in S. cerevisiae). In mammalian sytems Cet1 and Ceg1 are replaced by a bifunctional triphosphatase/guanyltransferase. CC
GO:0031530 gonadotropin-releasing hormone receptor binding Interacting selectively with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. MF
GO:0031531 thyrotropin-releasing hormone receptor binding Interacting selectively with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary. MF
GO:0031536 positive regulation of exit from mitosis Any processactivates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). BP
GO:0031537 regulation of anthocyanin metabolic process Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. BP
GO:0031534 minus-end directed microtubule sliding The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules. BP
GO:0031535 plus-end directed microtubule sliding The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules. BP
GO:0046879 hormone secretion The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. BP
GO:0046878 positive regulation of saliva secretion Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. BP
GO:0046871 N-acetylgalactosamine binding Interacting selectively with N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine. MF
GO:0046870 cadmium ion binding Interacting selectively with cadmium (Cd) ions. MF
GO:0046873 metal ion transporter activity Enables the directed movement of metal ions into, out of, within or between cells. MF
GO:0046872 metal ion binding Interacting selectively with any metal ion. MF
GO:0046875 ephrin receptor binding Interacting selectively with an ephrin receptor. MF
GO:0046874 quinolinate metabolic process The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. BP
GO:0046877 regulation of saliva secretion Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or group of cells. BP
GO:0046876 3,4-didehydroretinal binding Interacting selectively with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod). MF
GO:0047030 4-hydroxycyclohexanecarboxylate dehydrogenase activity Catalysis of the reaction: NAD+ + 4-hydroxycyclohexanecarboxylate = NADH + H+ + 4-oxocyclohexanecarboxylate. MF
GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. BP
GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of DNA-dependent transcription. BP
GO:0006356 regulation of transcription from RNA polymerase I promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter. BP
GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. BP
GO:0006350 transcription The synthesis of either RNA on a template of DNA or DNA on a template of RNA. BP
GO:0006351 transcription, DNA-dependent The synthesis of RNA on a template of DNA. BP
GO:0006352 transcription initiation Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter. BP
GO:0006353 transcription termination The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. BP
GO:0006358 regulation of global transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of global transcription from Pol II promoter. BP
GO:0006359 regulation of transcription from RNA polymerase III promoter Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. BP
GO:0042578 phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. MF
GO:0042579 microbody Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). CC
GO:0042571 immunoglobulin complex, circulating A multi-subunit complex that functions as an antibody and circulates in the blood, lymph, mucosal areas, and other fluids of the body. In its basic form, circulating immunoglobulin is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms are polymers of the basic structure and contain additional components such as J-chain and the secretory component. CC
GO:0042572 retinol metabolic process The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. BP
GO:0042573 retinoic acid metabolic process The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. BP
GO:0042574 retinal metabolic process The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. BP
GO:0042575 DNA polymerase complex Any of the multimeric enzyme complexes involved in template directed synthesis of DNA. CC
GO:0042576 aspartyl aminopeptidase activity Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate. MF
GO:0042577 lipid phosphatase activity Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. MF
GO:0000196 MAPKKK cascade during cell wall biogenesis Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase that occurs during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. BP
GO:0000197 activation of MAPKKK activity during cell wall biogenesis Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. BP
GO:0000198 activation of MAPKK activity during cell wall biogenesis Any process that initiates the activity of the inactive enzyme MAP kinase kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. BP
GO:0000199 activation of MAPK activity during cell wall biogenesis Any process that initiates the activity of the inactive enzyme MAP kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. BP
GO:0004860 protein kinase inhibitor activity Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. MF
GO:0004861 cyclin-dependent protein kinase inhibitor activity Stops, prevents or reduces the activity of a cyclin-dependent protein kinase. MF
GO:0004862 cAMP-dependent protein kinase inhibitor activity Stops, prevents or reduces the activity of a cAMP-dependent protein kinase. MF
GO:0004863 diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity NA MF
GO:0004864 protein phosphatase inhibitor activity Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from proteins. MF
GO:0004865 type 1 serine/threonine specific protein phosphatase inhibitor activity NA MF
GO:0004866 endopeptidase inhibitor activity Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides. MF
GO:0004867 serine-type endopeptidase inhibitor activity Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme. MF
GO:0004869 cysteine protease inhibitor activity NA MF
GO:0050678 regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation. BP
GO:0050679 positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation. BP
GO:0050674 urothelial cell proliferation The multiplication or reproduction of urothelial cells, resulting in the rapid expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria. BP
GO:0050675 regulation of urothelial cell proliferation Any process that modulates the frequency, rate or extent of urothelial cell proliferation. BP
GO:0050676 negative regulation of urothelial cell proliferation Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation. BP
GO:0050677 positive regulation of urothelial cell proliferation Any process that activates or increases the rate or extent of urothelial cell proliferation. BP
GO:0050670 regulation of lymphocyte proliferation Any process that modulates the frequency, rate or extent of lymphocyte proliferation. BP
GO:0050671 positive regulation of lymphocyte proliferation Any process that activates or increases the rate or extent of lymphocyte proliferation. BP
GO:0050672 negative regulation of lymphocyte proliferation Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. BP
GO:0050673 epithelial cell proliferation The multiplication or reproduction of epithelial cells, resulting in the rapid expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. BP
GO:0002329 pre-B cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments. BP
GO:0002328 pro-B cell differentiation The process whereby an unspecialized hemopoietic stem cell acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed. BP
GO:0005119 smoothened binding Interacting selectively with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. MF
GO:0005118 sevenless binding Interacting selectively with the sevenless (sev) protein, a receptor tyrosine kinase. MF
GO:0005117 wishful thinking binding Interacting selectively with wishful thinking (Wit), a type II bone morphogenic protein receptor. MF
GO:0002320 lymphoid progenitor cell differentiation The process whereby an unspecialized hemopoietic stem cell acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. BP
GO:0002323 natural killer cell activation during immune response The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0005114 punt binding Interacting selectively with the punt protein, a type II transforming growth factor beta receptor. MF
GO:0002325 natural killer cell differentiation during immune response The process whereby a nave natural killer cell acquires the specialized features of an effector natural killer T cell during an immune response. BP
GO:0048722 anterior cibarial plate development The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure. BP
GO:0002327 immature B cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an immature B cell. BP
GO:0002326 B cell lineage commitment The process whereby a lymphoid progenitor cell becomes committed to become any type of B cell. BP
GO:0051079 meiosis I nuclear envelope disassembly The controlled breakdown of the nuclear envelope during the first division of meiosis. BP
GO:0051078 meiotic nuclear envelope disassembly The cell cycle process whereby the controlled breakdown of the nuclear envelope during meiotic cell division occurs. BP
GO:0051075 S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA [preQ1-tRNA] = adenine + methionine + epoxyqueuosine-tRNA [oQ-tRNA]. MF
GO:0004245 neprilysin activity Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides. MF
GO:0051077 secondary cell septum (sensu Fungi) Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0004247 saccharolysin activity Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds. MF
GO:0004240 mitochondrial processing peptidase activity Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2. MF
GO:0051070 galactomannan biosynthetic process The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units. BP
GO:0051073 adenosylcobinamide-GDP ribazoletransferase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin. MF
GO:0051072 4,6-pyruvylated galactose residue biosynthetic process The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. BP
GO:0010119 regulation of stomatal movement Any process that modulates the frequency, rate or extent of stomatal movement. BP
GO:0010118 stomatal movement The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata). BP
GO:0010115 regulation of abscisic acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. BP
GO:0010114 response to red light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light has a wavelength of between 620 and 700nm. BP
GO:0010117 photoprotection Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis. BP
GO:0010116 positive regulation of abscisic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. BP
GO:0010111 glyoxysome organization and biogenesis The assembly and arrangement of the glyoxysome. BP
GO:0010110 regulation of photosynthesis, dark reaction Any process that modulates the frequency, rate or extent of photosynthesis dark reaction. BP
GO:0010113 negative regulation of systemic acquired resistance Any process that stops, prevents or reduces the frequency, rate or extent of systemic acquired resistance. BP
GO:0010112 regulation of systemic acquired resistance Any process that modulates the frequency, rate or extent of systemic acquired resistance. BP
GO:0018340 peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine The posttranslational modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine. BP
GO:0018341 peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process NA BP
GO:0018342 protein prenylation The enzymatic addition of prenyl moieties to proteins as a posttranslational modification; geranyl, farnesyl, or geranylgeranyl groups may be added. BP
GO:0018343 protein farnesylation The enzymatic addition of a farnesyl moiety to a protein as a posttranslational modification. BP
GO:0018344 protein geranylgeranylation The enzymatic addition of a geranylgeranyl moiety to a protein as a posttranslational modification. BP
GO:0018345 protein palmitoylation The covalent or non-covalent attachment of a palmitoyl moiety to a protein. BP
GO:0018346 protein amino acid prenylation The covalent or non-covalent attachment of a prenyl moiety to a protein amino acid. BP
GO:0018347 protein amino acid farnesylation The covalent or non-covalent attachment of a farnesyl moiety to a protein amino acid. BP
GO:0018348 protein amino acid geranylgeranylation The covalent or non-covalent attachment of a geranylgeranyl moiety to a protein amino acid. BP
GO:0001748 optic placode development (sensu Endopterygota) The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0001749 non-eye photoreceptor development (sensu Endopterygota) The process whose specific outcome is the progression of the non-eye photoreceptor over time, from its formation to the mature structure. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0001746 Bolwig's organ morphogenesis The process by which the anatomical structures of the larval eye in Drosophila are generated and organized. Morphogenesis pertains to the creation of form. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain. BP
GO:0001747 eye development (sensu Mammalia) The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0001744 optic placode formation (sensu Endopterygota) Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Droosphila for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0001745 compound eye morphogenesis (sensu Endopterygota) The process by which the anatomical structures of the compound eye are generated and organized. Morphogenesis pertains to the creation of form. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidia is composed of 20 cells, identified by cell type and position. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0001742 oenocyte differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. BP
GO:0001743 optic placode formation The initial developmental process that will lead to the formation of an eye. BP
GO:0001740 Barr body A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. CC
GO:0001741 XY body A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. CC
GO:0052522 positive regulation by organism of phagocytosis in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052520 positive regulation by organism of nutrient release from other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052521 positive regulation by host of symbiont phagocytosis Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052526 positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction. BP
GO:0052527 positive regulation by symbiont of host resistance gene-dependent defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052525 positive regulation by host of symbiont signal transduction pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052529 upregulation by organism of programmed cell death in other organism during symbiotic interaction Any process by which an organism increases the frequency, rate or extent of programmed cell death in the second organism, where the two organisms are in a symbiotic interaction. BP
GO:0016610 nitrogenase complex An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. CC
GO:0016611 iron-iron nitrogenase complex An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. CC
GO:0016612 molybdenum-iron nitrogenase complex An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. CC
GO:0016613 vanadium-iron nitrogenase complex An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. CC
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016615 malate dehydrogenase activity Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate using NAD+ or NADPH. MF
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. MF
GO:0016617 4-oxoproline reductase activity Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+. MF
GO:0016618 hydroxypyruvate reductase activity Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+. MF
GO:0016619 malate dehydrogenase (oxaloacetate-decarboxylating) activity Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Also decarboxylates oxaloacetate. MF
GO:0002439 chronic inflammatory response to antigenic stimulus A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual. BP
GO:0019431 acetyl-CoA biosynthetic process from ethanol The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde. BP
GO:0019430 removal of superoxide radicals The processes involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). BP
GO:0019433 triacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of triacylglycerol, any triester of glycerol. BP
GO:0019432 triacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of triacylglycerol, any triester of glycerol. BP
GO:0019435 sophorosyloxydocosanoate biosynthetic process The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate. BP
GO:0019434 sophorosyloxydocosanoate metabolic process The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon. BP
GO:0019436 sophorosyloxydocosanoate catabolic process The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate. BP
GO:0019439 aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. BP
GO:0019438 aromatic compound biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. BP
GO:0002438 acute inflammatory response to antigenic stimulus An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. BP
GO:0004281 pancreatic elastase II activity Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin. MF
GO:0004283 plasmin activity Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products. MF
GO:0004284 acrosin activity Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa. MF
GO:0004285 proprotein convertase 1 activity Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond. MF
GO:0004286 proprotein convertase 2 activity Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond. MF
GO:0004287 prolyl oligopeptidase activity Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides. MF
GO:0004289 subtilase activity NA MF
GO:0002434 immune complex clearance A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. BP
GO:0008748 N-ethylmaleimide reductase activity NA MF
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. MF
GO:0008744 L-xylulokinase activity Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate. MF
GO:0008747 N-acetylneuraminate lyase activity Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. MF
GO:0008746 NAD(P) transhydrogenase activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. MF
GO:0008741 ribulokinase activity Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. MF
GO:0008740 L-rhamnose isomerase activity Catalysis of the reaction: L-rhamnose = L-rhamnulose. MF
GO:0008743 L-threonine 3-dehydrogenase activity Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+. MF
GO:0008742 L-ribulose-phosphate 4-epimerase activity Catalysis of the reaction: L-ribulose 5-phosphate = D-xylose 5-phosphate. MF
GO:0046479 glycosphingolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. BP
GO:0046478 lactosylceramide metabolic process The chemical reactions and pathways involving lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides. BP
GO:0046475 glycerophospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. BP
GO:0046474 glycerophospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. BP
GO:0046477 glycosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. BP
GO:0046476 glycosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. BP
GO:0046471 phosphatidylglycerol metabolic process The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. BP
GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. BP
GO:0046473 phosphatidic acid metabolic process The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. BP
GO:0045922 negative regulation of fatty acid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. BP
GO:0045923 positive regulation of fatty acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. BP
GO:0045920 negative regulation of exocytosis Any process that stops, prevents or reduces the frequency, rate or extent of exocytosis. BP
GO:0045921 positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis. BP
GO:0045926 negative regulation of growth Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. BP
GO:0045927 positive regulation of growth Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. BP
GO:0045924 regulation of female receptivity Any process that modulates the frequency, rate or extent of the receptiveness of a female to male advances. BP
GO:0045925 positive regulation of female receptivity Any process that activates or increases the receptiveness of a female to male advances. BP
GO:0045928 negative regulation of juvenile hormone metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. BP
GO:0045929 positive regulation of juvenile hormone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. BP
GO:0043182 vacuolar sequestering of sodium ion The process of transporting sodium ions into, and confining within, a vacuole. BP
GO:0043183 vascular endothelial growth factor receptor 1 binding Interacting selectively with vascular endothelial growth factor receptor 1. MF
GO:0043180 rhythmic inhibition Processes involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit. BP
GO:0043181 vacuolar sequestering The process of transporting a substance into, and confining within, a vacuole. BP
GO:0009823 cytokinin catabolic process The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators. BP
GO:0009822 alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). BP
GO:0009821 alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). BP
GO:0043185 vascular endothelial growth factor receptor 3 binding Interacting selectively with vascular endothelial growth factor receptor 3. MF
GO:0043188 cell septum edging The cell wall material that surrounds the septum in fungal cells. CC
GO:0043189 H4/H2A histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. CC
GO:0009829 cell wall modification during ripening The series of events that occur during ripening that result in chemical or structural alterations of existing cell walls. BP
GO:0009828 cell wall loosening (sensu Magnoliophyta) The series of events causing chemical and structural alterations of an existing cell wall that results in greater extensibility of the wall. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0046298 2,4-dichlorobenzoate catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). BP
GO:0046290 isoflavonoid phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. BP
GO:0046293 formaldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde. BP
GO:0046292 formaldehyde metabolic process The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent. BP
GO:0046295 glycolate biosynthetic process The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid). BP
GO:0046294 formaldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. BP
GO:0046296 glycolate catabolic process The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid). BP
GO:0048529 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. MF
GO:0048528 post-embryonic root development The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure. BP
GO:0048525 negative regulation of viral life cycle Any process that stops, prevents or reduces the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. BP
GO:0048524 positive regulation of viral life cycle Any process that activates or increases the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. BP
GO:0048527 lateral root development The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. BP
GO:0048526 wing expansion The process of expanding or inflating the folded pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing. BP
GO:0048521 negative regulation of behavior Any process that stops, prevents or reduces the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli. BP
GO:0048520 positive regulation of behavior Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli. BP
GO:0048523 negative regulation of cellular process Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. BP
GO:0048522 positive regulation of cellular process Any process that activates or increases the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. BP
GO:0048297 negative regulation of isotype switching to IgA isotypes Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgA isotypes. BP
GO:0048296 regulation of isotype switching to IgA isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes. BP
GO:0048295 positive regulation of isotype switching to IgE isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes. BP
GO:0048294 negative regulation of isotype switching to IgE isotypes Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgE isotypes. BP
GO:0048293 regulation of isotype switching to IgE isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes. BP
GO:0048292 isotype switching to IgD isotypes The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus. BP
GO:0048291 isotype switching to IgG isotypes The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus. BP
GO:0048290 isotype switching to IgA isotypes The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus. BP
GO:0048299 regulation of isotype switching to IgD isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes. BP
GO:0048298 positive regulation of isotype switching to IgA isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes. BP
GO:0046300 2,4-dichlorophenoxyacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds. BP
GO:0046306 alkanesulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety. BP
GO:0050267 rubber cis-polyprenylcistransferase activity Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit. MF
GO:0050266 rosmarinate synthase activity Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate. MF
GO:0050265 RNA uridylyltransferase activity Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). MF
GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0050263 ribosylpyrimidine nucleosidase activity Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine. MF
GO:0050262 ribosylnicotinamide kinase activity Catalysis of the reaction: ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide. MF
GO:0050261 ribose isomerase activity Catalysis of the reaction: D-ribose = D-ribulose. MF
GO:0050260 ribose-5-phosphate-ammonia ligase activity Catalysis of the reaction: ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine. MF
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. MF
GO:0009179 purine ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009178 pyrimidine deoxyribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0050269 coniferyl-aldehyde dehydrogenase activity Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+. MF
GO:0050268 coniferyl-alcohol dehydrogenase activity Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH. MF
GO:0008888 glycerol dehydrogenase activity Catalysis of the reaction: glycerol + NAD+ = glycerone + NADH + H+. MF
GO:0008889 glycerophosphodiester phosphodiesterase activity Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. MF
GO:0008886 glyceraldehyde-3-phosphate dehydrogenase (NADP+) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+. MF
GO:0008887 glycerate kinase activity Catalysis of the reaction: ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate. MF
GO:0008884 glutathionylspermidine amidase activity Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine. MF
GO:0008885 glutathionylspermidine synthase activity Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate. MF
GO:0008882 [glutamate-ammonia-ligase] adenylyltransferase activity Catalysis of the reaction: ATP + (L-glutamate:ammonia ligase (ADP-forming)) = diphosphate + adenylyl-(L-glutamate:ammonia ligase (ADP-forming)). MF
GO:0008883 glutamyl-tRNA reductase activity Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. MF
GO:0008880 glucuronate isomerase activity Catalysis of the reaction: D-glucuronate = D-fructuronate. MF
GO:0008881 glutamate racemase activity Catalysis of the reaction: L-glutamate = D-glutamate. MF
GO:0008228 opsonization The process by which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. BP
GO:0008226 tyramine receptor activity Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine. MF
GO:0008227 amine receptor activity Combining with a biogenic amine to initiate a change in cell activity. MF
GO:0002549 negative regulation of plasma kallikrein-kinin cascade Any process that stops, prevents or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade. BP
GO:0002548 monocyte chemotaxis The movement of a monocyte in response to an external stimulus. BP
GO:0002541 activation of plasma proteins during acute inflammatory response Any process activating plasma proteins via proteolysis during an acute inflammatory response. BP
GO:0002540 leukotriene production during acute inflammatory response The synthesis or release of any leukotriene following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002543 activation of blood coagulation via clotting cascade Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot. BP
GO:0002542 Factor XII activation Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. BP
GO:0002545 chronic inflammatory response to non-antigenic stimulus A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma. BP
GO:0002544 chronic inflammatory response Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. BP
GO:0002547 positive regulation of tissue kallikrein-kinin cascade Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade. BP
GO:0002546 negative regulation of tissue kallikrein-kinin cascade Any process that stops, prevents or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade. BP
GO:0032669 regulation of interleukin-25 production Any process that modulates the frequency, rate, or extent of interleukin-25 production. BP
GO:0032668 regulation of interleukin-24 production Any process that modulates the frequency, rate, or extent of interleukin-24 production. BP
GO:0032667 regulation of interleukin-23 production Any process that modulates the frequency, rate, or extent of interleukin-23 production. BP
GO:0032666 regulation of interleukin-22 production Any process that modulates the frequency, rate, or extent of interleukin-22 production. BP
GO:0032665 regulation of interleukin-21 production Any process that modulates the frequency, rate, or extent of interleukin-21 production. BP
GO:0032664 regulation of interleukin-20 production Any process that modulates the frequency, rate, or extent of interleukin-20 production. BP
GO:0032663 regulation of interleukin-2 production Any process that modulates the frequency, rate, or extent of interleukin-2 production. BP
GO:0032662 regulation of interleukin-19 production Any process that modulates the frequency, rate, or extent of interleukin-19 production. BP
GO:0032661 regulation of interleukin-18 production Any process that modulates the frequency, rate, or extent of interleukin-18 production. BP
GO:0032660 regulation of interleukin-17 production Any process that modulates the frequency, rate, or extent of interleukin-17 production. BP
GO:0048888 neuromast mantle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. BP
GO:0048889 neuromast support cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. BP
GO:0048882 lateral line development The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear. BP
GO:0048883 neuromast primordium migration The migration of a cluster of relatively undifferentiated cells originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop. BP
GO:0048880 sensory system development The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. BP
GO:0005091 guanyl-nucleotide exchange factor adaptor activity NA MF
GO:0005096 GTPase activator activity Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. MF
GO:0005097 Rab GTPase activator activity Increases the rate of GTP hydrolysis by a GTPase of the Rab family. MF
GO:0005094 Rho GDP-dissociation inhibitor activity NA MF
GO:0048885 neuromast deposition The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line. BP
GO:0006679 glucosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. BP
GO:0006678 glucosylceramide metabolic process The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative. BP
GO:0006677 glycosylceramide metabolic process The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. BP
GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains two phosphoryl (-P(O)=) groups and a mannose derivative. BP
GO:0006675 mannose inositol phosphoceramide metabolic process The chemical reactions and pathways involving mannose inositol phosphoceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains a phosphoryl (-P(O)=) groups and a mannose derivative. BP
GO:0006674 inositol phosphorylceramide metabolic process The chemical reactions and pathways involving inositol phosphorylceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety. The phosphate-containing moiety is the trivalent -P(O)= and the ceramide moiety of this lipid consists of phytosphingosine and a hydroxy C26 fatty acid. BP
GO:0006673 inositolphosphoceramide metabolic process The chemical reactions and pathways involving inositolphosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety. BP
GO:0006672 ceramide metabolic process The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. BP
GO:0006671 phytosphingosine metabolic process The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-amino-1,3,4-octadecanetriol, a constituent of many plant sphingolipids. BP
GO:0006670 sphingosine metabolic process The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. BP
GO:0005328 neurotransmitter:sodium symporter activity Catalysis of the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). MF
GO:0005329 dopamine transporter activity Enables the directed movement of dopamine into, out of, within or between cells. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. MF
GO:0005324 long-chain fatty acid transporter activity Enables the directed movement of long-chain fatty acids into, out of, within or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons. MF
GO:0005325 peroxisomal fatty acyl CoA transporter activity Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes. MF
GO:0005326 neurotransmitter transporter activity Enables the directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. MF
GO:0000781 chromosome, telomeric region The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. CC
GO:0000780 condensed nuclear chromosome, pericentric region The central region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. CC
GO:0000783 nuclear telomere cap complex A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. CC
GO:0000782 telomere cap complex A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. CC
GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. CC
GO:0000784 nuclear chromosome, telomeric region The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins. CC
GO:0000787 cytoplasmic nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures. CC
GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. CC
GO:0000789 cytoplasmic chromatin The ordered and organized complex of DNA and protein that forms the chromosome in the cytoplasm. CC
GO:0000788 nuclear nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. CC
GO:0051436 negative regulation of ubiquitin ligase activity during mitotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle. BP
GO:0010098 suspensor development The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm. BP
GO:0010099 regulation of photomorphogenesis Any process that modulates the rate or extent of photomorphogenesis. BP
GO:0010090 trichome morphogenesis (sensu Magnoliophyta) The process by which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0010091 trichome branching (sensu Magnoliophyta) The processes involved in the formation of branches in plant hair cells (trichomes); as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0010092 specification of organ identity The regionalization process by which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010093 specification of floral organ identity The process by which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010094 specification of carpel identity The process by which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010095 specification of petal identity The process by which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010096 specification of sepal identity The process by which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010097 specification of stamen identity The process by which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0015570 energizer of outer membrane receptor-mediated transport activity NA MF
GO:0007257 activation of JNK activity The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK). BP
GO:0007254 JNK cascade A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress. BP
GO:0015573 beta-glucoside transporter activity Enables the directed movement of beta-glucosides into, out of, within or between cells. Beta-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. MF
GO:0007252 I-kappaB phosphorylation The process of introducing a phosphoric group into an I-kappaB protein. BP
GO:0015575 mannitol transporter activity Enables the directed movement of mannitol into, out of, within or between cells. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. MF
GO:0015576 sorbitol transporter activity Enables the directed movement of sorbitol into, out of, within or between cells. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. MF
GO:0015577 galactitol transporter activity Enables the directed movement of galactitol into, out of, within or between cells. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. MF
GO:0015578 mannose transporter activity Enables the directed movement of mannose into, out of, within or between cells. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. MF
GO:0015579 glucose permease activity Catalysis of the stereospecific transfer of the hexose monosaccharide glucose across a biological membrane. MF
GO:0007258 JUN phosphorylation The process of introducing a phosphoric group into a JUN protein. BP
GO:0007259 JAK-STAT cascade The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. BP
GO:0019606 2-oxobutyrate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2. BP
GO:0019607 phenylethylamine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. BP
GO:0019604 toluene oxidation to catechol The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2). BP
GO:0019605 butyrate metabolic process The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid. BP
GO:0019602 toluene oxidation via 3-hydroxytoluene The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol). BP
GO:0019603 toluene oxidation via 4-hydroxytoluene The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol). BP
GO:0019600 toluene oxidation NA BP
GO:0019601 toluene oxidation via 2-hydroxytoluene The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol). BP
GO:0019608 nicotine catabolic process The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. BP
GO:0019609 3-hydroxyphenylacetate metabolic process The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. BP
GO:0008091 spectrin Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. CC
GO:0001959 regulation of cytokine and chemokine mediated signaling pathway Any process that modulates the frequency, rate or extent of the cytokine and chemokine mediated signaling pathway. BP
GO:0001958 endochondral ossification The formation of bone by the replacement of cartilage tissue with mineralized bone. BP
GO:0001957 intramembranous ossification The formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified. Intramembranous ossification is the way flat bones and the shell of a turtle are formed. BP
GO:0001956 positive regulation of neurotransmitter secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. BP
GO:0001955 blood vessel maturation A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. BP
GO:0001954 positive regulation of cell-matrix adhesion Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. BP
GO:0001953 negative regulation of cell-matrix adhesion Any process that stops, prevents or reduces the rate or extent of cell adhesion to the extracellular matrix. BP
GO:0001952 regulation of cell-matrix adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. BP
GO:0001951 D-glucose absorption Uptake of D-glucose into the blood by absorption from the small intestine. BP
GO:0001950 PME fraction The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes. CC
GO:0021809 neurotrophic factor signaling initiating cell movement, involved in cerebral cortex glial-mediated radial migration Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration. BP
GO:0021808 cytosolic calcium signaling involved in the initiation of cell movement in glial-mediated radial cell migration The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration. BP
GO:0021803 pial surface process extension The extension of a long process to the pial surface as a cell leaves the ventricular zone. BP
GO:0021802 somal translocation The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate. BP
GO:0021801 cerebral cortex radial glia guided migration The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. BP
GO:0021800 cerebral cortex tangential migration The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. BP
GO:0021807 motogenic signaling initiating cell movement in the cerebral cortex The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex. BP
GO:0021806 initiation of movement involved in cerebral cortex glial-mediated radial cell migration The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex. BP
GO:0021805 cell movement involved in somal translocation The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface. BP
GO:0021804 negative regulation of cell adhesion in the ventricular zone The process that results in the loss of attachments of a cell in the ventricular zone. BP
GO:0008098 5S rRNA primary transcript binding Interacting selectively with the unprocessed 5S ribosomal RNA transcript. MF
GO:0016000 iota DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). A low fidelity DNA-directed DNA polymerase involved in translesion DNA synthesis. MF
GO:0016002 sulfite reductase activity Catalysis of the reaction: H2S + acceptor + 3 H2O = SO3(2-) (sulfite) + reduced acceptor. MF
GO:0016005 phospholipase A2 activator activity Increases the activity of the enzyme phospholipase A2. MF
GO:0016004 phospholipase activator activity Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. MF
GO:0016007 mitochondrial derivative The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation. CC
GO:0016006 Nebenkern A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme. CC
GO:0016009 minor mitochondrial derivative NA CC
GO:0016008 major mitochondrial derivative NA CC
GO:0035198 miRNA binding Interacting selectively with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. MF
GO:0035199 salt aversion The specific avoidance actions or reactions of an organism in response to the perception of salt. BP
GO:0031749 D2 dopamine receptor binding Interacting selectively with a D2 dopamine receptor. MF
GO:0031748 D1 dopamine receptor binding Interacting selectively with a D1 dopamine receptor. MF
GO:0031745 cysteinyl leukotriene receptor binding Interacting selectively with a cysteinyl leukotriene receptor. MF
GO:0031744 type 2 corticotropin releasing factor receptor binding Interacting selectively with a type 2 corticotropin releasing factor receptor. MF
GO:0031747 type 2 cysteinyl leukotriene receptor binding Interacting selectively with a type 2 cysteinyl leukotriene receptor. MF
GO:0031746 type 1 cysteinyl leukotriene receptor binding Interacting selectively with a type 1 cysteinyl leukotriene receptor. MF
GO:0031741 type B gastrin/cholecystokinin receptor binding Interacting selectively with a type B gastrin/cholecystokinin receptor. MF
GO:0031740 type A cholecystokinin receptor binding Interacting selectively with a type A cholecystokinin receptor. MF
GO:0031743 type 1 corticotropin releasing factor receptor binding Interacting selectively with a type 1 corticotropin releasing factor receptor. MF
GO:0031742 corticotropin releasing factor receptor binding Interacting selectively with a corticotropin releasing factor receptor. MF
GO:0051949 negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. BP
GO:0017069 snRNA binding Interacting selectively with a small nuclear RNA (snRNA). MF
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. MF
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. MF
GO:0051943 positive regulation of amino acid uptake during transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. BP
GO:0051942 negative regulation of amino acid uptake during transmission of nerve impulse Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. BP
GO:0051945 negative regulation of catecholamine uptake during transmission of nerve impulse Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. BP
GO:0051944 positive regulation of catecholamine uptake during transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. BP
GO:0051947 regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. BP
GO:0051946 regulation of glutamate uptake during transmission of nerve impulse Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. BP
GO:0048749 compound eye development (sensu Endopterygota) The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0009379 Holliday junction helicase complex NA CC
GO:0009378 Holliday junction helicase activity Catalysis of the unwinding of the DNA helix of a Holliday junction. MF
GO:0048748 eye morphogenesis (sensu Endopterygota) The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0009373 regulation of transcription by pheromones Any process involving pheromones that modulates the frequency, rate or extent of transcription. BP
GO:0009372 quorum sensing The process in which single-celled organisms, usually bacteria, monitor population density by detecting the concentration of small diffusible signal molecules. BP
GO:0009371 positive regulation of transcription by pheromones Any process involving pheromones that activates or increases the rate of transcription. BP
GO:0009370 quorum sensing response regulator activity NA MF
GO:0009377 HslUV protease activity NA MF
GO:0009376 HslUV protease complex NA CC
GO:0009375 ferredoxin hydrogenase complex An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances. CC
GO:0009374 biotin binding Interacting selectively with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. MF
GO:0016566 specific transcriptional repressor activity Any activity that stops or downregulates transcription of specific genes or sets of genes. MF
GO:0016564 transcriptional repressor activity Any transcription regulator activity that prevents or downregulates transcription. MF
GO:0048741 skeletal muscle fiber development The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. BP
GO:0016565 general transcriptional repressor activity Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set. MF
GO:0048740 striated muscle fiber development The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers. BP
GO:0046534 positive regulation of photoreceptor cell differentiation Any process that activates or increases the frequency, rate or extent of photoreceptor differentiation. BP
GO:0048743 positive regulation of skeletal muscle fiber development Any process that activates, maintains or increases the rate of skeletal muscle fiber development. BP
GO:0016563 transcriptional activator activity Any transcription regulator activity required for initiation or upregulation of transcription. MF
GO:0005172 vascular endothelial growth factor receptor binding Interacting selectively with any vascular endothelial growth factor receptor. MF
GO:0046536 dosage compensation complex A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes. CC
GO:0048745 smooth muscle development The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. BP
GO:0016561 protein import into peroxisome matrix, translocation The process by which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation. BP
GO:0048744 negative regulation of skeletal muscle fiber development Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber development. BP
GO:0048746 smooth muscle fiber development The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure. BP
GO:0035190 syncytial nuclear migration The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. BP
GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. MF
GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds Catalysis of the hydrolysis of any acid carbon-carbon bond. MF
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. MF
GO:0016827 hydrolase activity, acting on acid carbon-phosphorus bonds Catalysis of the hydrolysis of any acid carbon-phosphorus bond. MF
GO:0016826 hydrolase activity, acting on acid sulfur-nitrogen bonds Catalysis of the hydrolysis of any acid sulfur-nitrogen bond. MF
GO:0016825 hydrolase activity, acting on acid phosphorus-nitrogen bonds Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond. MF
GO:0016824 hydrolase activity, acting on acid halide bonds Catalysis of the hydrolysis of any acid halide bond. MF
GO:0016829 lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. MF
GO:0016828 hydrolase activity, acting on acid sulfur-sulfur bonds Catalysis of the hydrolysis of any acid sulfur-sulfur bond. MF
GO:0045351 interferon type I biosynthetic process The chemical reactions and pathways resulting in the formation of interferon type I. BP
GO:0045350 interferon-beta biosynthetic process The chemical reactions and pathways resulting in the formation of interferon-beta. BP
GO:0045353 interleukin-1 Type II receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 Type II receptors. MF
GO:0045352 interleukin-1 Type I receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 Type I receptors. MF
GO:0045355 negative regulation of interferon-alpha biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha. BP
GO:0045354 regulation of interferon-alpha biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha. BP
GO:0045357 regulation of interferon-beta biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta. BP
GO:0045356 positive regulation of interferon-alpha biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha. BP
GO:0045359 positive regulation of interferon-beta biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta. BP
GO:0045358 negative regulation of interferon-beta biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta. BP
GO:0045689 negative regulation of antipodal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of antipodal cell differentiation. BP
GO:0045688 regulation of antipodal cell differentiation Any process that modulates the frequency, rate or extent of antipodal cell differentiation. BP
GO:0045683 negative regulation of epidermis development Any process that stops, prevents or reduces the frequency, rate or extent of epidermis development. BP
GO:0045682 regulation of epidermis development Any process that modulates the frequency, rate or extent of epidermis development. BP
GO:0045681 positive regulation of R8 differentiation Any process that activates or increases the frequency, rate or extent of R8 differentiation. BP
GO:0045680 negative regulation of R8 differentiation Any process that stops, prevents or reduces the frequency, rate or extent of R8 differentiation. BP
GO:0045687 positive regulation of glial cell differentiation Any process that activates or increases the frequency, rate or extent of glia cell differentiation. BP
GO:0045686 negative regulation of glial cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of glia cell differentiation. BP
GO:0045685 regulation of glial cell differentiation Any process that modulates the frequency, rate or extent of glia cell differentiation. BP
GO:0045684 positive regulation of epidermis development Any process that activates or increases the frequency, rate or extent of epidermis development. BP
GO:0032469 endoplasmic reticulum calcium ion homeostasis The regulation of the levels, transport, and metabolism of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. BP
GO:0032468 Golgi calcium ion homeostasis The regulation of the levels, transport, and metabolism of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings. BP
GO:0032465 regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. BP
GO:0032464 positive regulation of protein homooligomerization Any process that activates or increases the frequency, rate or extent of protein homooligomerization. BP
GO:0032467 positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of cytokinesis. BP
GO:0032466 negative regulation of cytokinesis Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis. BP
GO:0032461 positive regulation of protein oligomerization Any process that activates or increases the frequency, rate or extent of protein oligomerization. BP
GO:0032460 negative regulation of protein oligomerization Any process that stops, prevents or reduces the frequency, rate or extent of protein oligomerization. BP
GO:0032463 negative regulation of protein homooligomerization Any process that stops, prevents or reduces the frequency, rate or extent of protein homooligomerization. BP
GO:0032462 regulation of protein homooligomerization Any process that modulates the frequency, rate or extent of protein homooligomerization. BP
GO:0016519 gastric inhibitory peptide receptor activity Combining with gastric inhibitory peptide to initiate a change in cell activity. MF
GO:0030827 negative regulation of cGMP biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. BP
GO:0030826 regulation of cGMP biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. BP
GO:0030825 positive regulation of cGMP metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP. BP
GO:0030824 negative regulation of cGMP metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP. BP
GO:0030823 regulation of cGMP metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. BP
GO:0030822 positive regulation of cAMP catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030821 negative regulation of cAMP catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030820 regulation of cAMP catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030829 regulation of cGMP catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP. BP
GO:0030828 positive regulation of cGMP biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. BP
GO:0015039 NADPH-adrenodoxin reductase activity Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+. MF
GO:0015038 glutathione disulfide oxidoreductase activity NA MF
GO:0047269 poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP. MF
GO:0047268 galactinol-raffinose galactosyltransferase activity Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol. MF
GO:0047263 N-acylsphingosine galactosyltransferase activity Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP. MF
GO:0047262 polygalacturonate 4-alpha-galacturonosyltransferase activity Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP. MF
GO:0047261 steroid N-acetylglucosaminyltransferase activity Catalysis of the reaction: estradiol-17-alpha 3-D-glucuronoside + UDP-N-acetyl-D-glucosamine = 17-alpha-(N-acetyl-D-glucosaminyl)estradiol 3-D-glucuronoside + UDP. MF
GO:0047260 alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP. MF
GO:0047267 undecaprenyl-phosphate mannosyltransferase activity Catalysis of the reaction: undecaprenyl phosphate + GDP-mannose = D-mannosyl-1-phosphoundecaprenol + GDP. MF
GO:0047266 poly(ribitol-phosphate) beta-glucosyltransferase activity Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP. MF
GO:0047265 poly(glycerol-phosphate) alpha-glucosyltransferase activity Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP. MF
GO:0015036 disulfide oxidoreductase activity NA MF
GO:0050847 progesterone receptor signaling pathway Any series of molecular signals generated as a consequence of a progesterone binding to its receptor. BP
GO:0050846 teichuronic acid metabolic process The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. BP
GO:0050845 teichuronic acid biosynthetic process The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. BP
GO:0050844 peptidyl-selenocysteine modification The modification of peptidyl-selenocysteine. BP
GO:0050843 S-adenosylmethionine catabolic process The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. BP
GO:0050842 copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. BP
GO:0050841 peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. BP
GO:0050840 extracellular matrix binding Interacting selectively with a component of the extracellular matrix. MF
GO:0050849 negative regulation of calcium-mediated signaling Any process that stops, prevents or reduces the frequency, rate or extent of calcium-mediated signaling. BP
GO:0050848 regulation of calcium-mediated signaling Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process by which a cell uses calcium ions to convert an extracellular signal into a response. BP
GO:0047199 phosphatidylcholine-dolichol O-acyltransferase activity Catalysis of the reaction: dolichol + phosphatidylcholine = acyldolichol + 1-acyl-sn-glycero-3-phosphocholine. MF
GO:0047198 cysteine-S-conjugate N-acetyltransferase activity Catalysis of the reaction: an S-substituted L-cysteine + acetyl-CoA = an S-substituted N-acetyl-L-cysteine + CoA. MF
GO:0047195 diacylglycerol-sterol O-acyltransferase activity Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol. MF
GO:0047194 indoleacetylglucose-inositol O-acyltransferase activity Catalysis of the reaction: myo-inositol + indole-3-acetyl-beta-1-D-glucose = indole-3-acetyl-myo-inositol + beta-D-glucose. MF
GO:0047197 triacylglycerol-sterol O-acyltransferase activity Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol. MF
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA. MF
GO:0047191 1-alkylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA. MF
GO:0047190 2-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. MF
GO:0047193 CDP-acylglycerol O-arachidonoyltransferase activity Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA. MF
GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. MF
GO:0035271 ring gland development Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones. BP
GO:0035270 endocrine system development Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. BP
GO:0035273 phthalate binding Interacting selectively with a phthalate, any ester or salt of phthalic acid. MF
GO:0035272 exocrine system development Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. BP
GO:0035275 dibutyl phthalate binding Interacting selectively with dibutyl phthalate, C(16)H(22)O(4). MF
GO:0035274 diphenyl phthalate binding Interacting selectively with diphenyl phthalate, C(20)H(14)O(4). MF
GO:0035277 spiracle morphogenesis The process by which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk. BP
GO:0035276 ethanol binding Interacting selectively with ethanol, CH(3)-CH(2)-OH. MF
GO:0035279 miRNA-mediated gene silencing, mRNA cleavage The process by which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism. BP
GO:0035278 miRNA-mediated gene silencing, negative regulation of translation The process by which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically repress translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. BP
GO:0030175 filopodium Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. CC
GO:0030174 regulation of DNA replication initiation Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. BP
GO:0030177 positive regulation of Wnt receptor signaling pathway Any process that activates or increases the frequency, rate or extent of Wnt receptor signaling pathway activity. BP
GO:0030176 integral to endoplasmic reticulum membrane Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0030171 voltage-gated proton channel activity A voltage-gated proton channel; unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is three orders of magnitude lower than that of most ion channels. MF
GO:0030170 pyridoxal phosphate binding Interacting selectively with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. MF
GO:0030173 integral to Golgi membrane Penetrating at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0030172 troponin C binding Interacting selectively with troponin C, the calcium-binding subunit of the troponin complex. MF
GO:0030178 negative regulation of Wnt receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of Wnt receptor signaling pathway activity. BP
GO:0031889 urotensin receptor binding Interacting selectively with a urotensin receptor. MF
GO:0031886 type 1 member 3 taste receptor binding Interacting selectively with a type 1 member 3 taste receptor. MF
GO:0031887 lipid particle transport along microtubule The directed movement of a lipid particle along a microtubule, mediated by motor proteins. BP
GO:0031884 type 1 member 1 taste receptor binding Interacting selectively with a type 1 member 1 taste receptor. MF
GO:0031885 type 1 member 2 taste receptor binding Interacting selectively with a type 1 member 2 taste receptor. MF
GO:0031882 type 5 somatostatin receptor binding Interacting selectively with a type 5 somatostatin receptor. MF
GO:0031883 taste receptor binding Interacting selectively with a taste receptor. MF
GO:0031880 type 3 somatostatin receptor binding Interacting selectively with a type 3 somatostatin receptor. MF
GO:0031881 type 4 somatostatin receptor binding Interacting selectively with a type 4 somatostatin receptor. MF
GO:0043029 T cell homeostasis The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. BP
GO:0043028 caspase regulator activity Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. MF
GO:0043021 ribonucleoprotein binding Interacting selectively with any complex of RNA and protein. MF
GO:0043020 NADPH oxidase complex A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. CC
GO:0043023 ribosomal large subunit binding Interacting selectively with any part of the larger ribosomal subunit. MF
GO:0043022 ribosome binding Interacting selectively with any part of a ribosome. MF
GO:0043025 cell soma The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. CC
GO:0043024 ribosomal small subunit binding Interacting selectively with any part of the small ribosomal subunit. MF
GO:0043027 caspase inhibitor activity Stops, prevents or reduces the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. MF
GO:0048312 intracellular distribution of mitochondria The processes that establish the spatial arrangement of mitochondria within the cell. BP
GO:0048313 Golgi inheritance The partitioning of Golgi apparatus between daughter cells at cell division. BP
GO:0048310 nucleus inheritance The partitioning of nuclei between daughter cells at cell division. BP
GO:0048311 mitochondrion distribution The processes that establish the spatial arrangement of mitochondria between and within cells. BP
GO:0048316 seed development The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves. BP
GO:0048317 seed morphogenesis The process by which the anatomical structures of the seed are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048314 embryo sac morphogenesis The process by which the anatomical structures of the embryo sac are generated and organized. Morphogenesis pertains to the creation of form. The female gametophyte or embryo sac develops from the megaspore in heterosporous plants. BP
GO:0048315 conidium formation Formation of asexual, nonmotile spores in fungi, by conversion of hyphal elements or arising from specialized sporogenous cells. BP
GO:0048318 axial mesoderm development The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. BP
GO:0048319 axial mesoderm morphogenesis The process by which the anatomical structures of the axial mesoderm are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0004437 inositol or phosphatidylinositol phosphatase activity Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. MF
GO:0004436 phosphatidylinositol diacylglycerol-lyase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol. MF
GO:0004435 phosphoinositide phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. MF
GO:0004434 inositol or phosphatidylinositol phosphodiesterase activity NA MF
GO:0004430 1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. MF
GO:0004439 phosphoinositide 5-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. MF
GO:0004438 phosphatidylinositol-3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. MF
GO:0008925 maltose O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose. MF
GO:0008924 malate dehydrogenase (acceptor) activity Catalysis of the reaction: (S)-malate + acceptor = oxaloacetate + reduced acceptor. MF
GO:0008927 mannonate dehydratase activity Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. MF
GO:0008926 mannitol-1-phosphate 5-dehydrogenase activity Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. MF
GO:0008921 lipopolysaccharide-1,6-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide. MF
GO:0008920 lipopolysaccharide heptosyltransferase activity NA MF
GO:0008923 lysine decarboxylase activity Catalysis of the reaction: L-lysine = cadaverine + CO2. MF
GO:0008922 long-chain-fatty-acid-[acyl-carrier-protein] ligase activity Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. MF
GO:0008929 methylglyoxal synthase activity Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate. MF
GO:0008928 mannose-1-phosphate guanylyltransferase (GDP) activity Catalysis of the reaction: GDP + D-mannose 1-phosphate = phosphate + GDP-mannose. MF
GO:0031228 intrinsic to Golgi membrane Located in the Golgi membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031229 intrinsic to nuclear inner membrane Located in the nuclear inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0042648 chloroplast chromosome A circular DNA molecule containing chloroplast encoded genes. CC
GO:0042649 prothylakoid Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light. CC
GO:0031222 arabinan catabolic process The chemical reactions and pathways resulting in the breakdown of arabinan, a branched homopolymer of L-arabinose. BP
GO:0031223 auditory behavior The actions or reactions of an organism in response to a sound. BP
GO:0031220 maltodextrin phosphorylase activity Catalysis of the reaction: maltodextrin = glucose-1-phosphate. MF
GO:0031221 arabinan metabolic process The chemical reactions and pathways involving arabinan, a branched homopolymer of L-arabinose. BP
GO:0042642 actomyosin, myosin complex part The myosin part of any complex of actin, myosin, and accessory proteins. CC
GO:0042643 actomyosin, actin part The actin part of any complex of actin, myosin, and accessory proteins. CC
GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031225 anchored to membrane Tethered to a membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane. CC
GO:0050542 icosanoid binding Interacting selectively with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. MF
GO:0050543 icosatetraenoic acid binding Interacting selectively with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule. MF
GO:0050540 2-aminomuconate deaminase activity Catalysis of the reaction: 2-aminomuconate + H2O = 4-oxalocrotonate + NH3. MF
GO:0050541 beta,beta-carotene-9',10'-dioxygenase activity Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone. MF
GO:0050546 4-hydroxyphenylpyruvate decarboxylase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2. MF
GO:0050547 vanillin synthase activity Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA = vanillin + acetyl-CoA. MF
GO:0050544 arachidonic acid binding Interacting selectively with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. MF
GO:0050545 sulfopyruvate decarboxylase activity Catalysis of the reaction: 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2. MF
GO:0050548 trans-feruloyl-CoA hydratase activity Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA. MF
GO:0050549 cyclohexyl-isocyanide hydratase activity Catalysis of the reaction: N-cyclohexylformamide = cyclohexyl isocyanide + H2O. MF
GO:0018717 9-phenanthrol glycosyltransferase activity Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O. MF
GO:0018716 1-phenanthrol glycosyltransferase activity Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O. MF
GO:0018715 9-phenanthrol UDP-glucuronosyltransferase activity Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP. MF
GO:0018713 3-ketopimelyl-CoA thiolase activity Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA. MF
GO:0018712 3-hydroxybutyryl-CoA thiolase activity Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA. MF
GO:0018711 benzoyl acetate-CoA thiolase activity Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA. MF
GO:0018710 acetone carboxylase activity Catalysis of the reaction: acetone + ATP + 2 H2O + CO2 = AMP + 2 phosphate + acetoacetate. MF
GO:0018719 6-aminohexanoate transaminase activity Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate. MF
GO:0018718 1,2-dihydroxy-phenanthrene glycosyltransferase activity Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP. MF
GO:0019044 latent virus maintenance The processes required for maintaining the latent form of the viral genome within a cell. BP
GO:0019045 latent virus replication The processes required for latent viral replication in a cell. BP
GO:0019046 reactivation of latent virus The reactivation of a virus from a latent to a lytic state. BP
GO:0019047 provirus integration The molecular events that lead to the integration of a viral genome into the host genome. BP
GO:0019041 viral antireceptor activity NA MF
GO:0019042 latent virus infection A viral process characterized by (a) the lack of efficient expression of all the viral genes that are transcribed during productive infection, and (b) the activation of a unique latent transcriptional progam. BP
GO:0019043 establishment of viral latency The process by which a virus reaches a latent state. BP
GO:0019048 virus-host interaction Interactions, directly with the host cell macromolecular machinery, to allow virus replication. BP
GO:0019049 evasion of host defenses by virus Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0050094 methionine-glyoxylate transaminase activity Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine. MF
GO:0050095 methionine decarboxylase activity Catalysis of the reaction: L-methionine = 3-methylthiopropanamine + CO2. MF
GO:0050096 methylaspartate ammonia-lyase activity Catalysis of the reaction: L-threo-3-methylaspartate = mesaconate + NH3. MF
GO:0050097 methylaspartate mutase activity Catalysis of the reaction: L-threo-3-methylaspartate = L-glutamate. MF
GO:0050090 mannuronate reductase activity Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+. MF
GO:0050091 melilotate 3-monooxygenase activity Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O. MF
GO:0050092 meso-tartrate dehydrogenase activity Catalysis of the reaction: meso-tartrate + NAD+ = dihydroxyfumarate + NADH. MF
GO:0050093 methanol dehydrogenase activity Catalysis of the reaction: methanol + NAD+ = formaldehyde + NADH. MF
GO:0050098 methylguanidinase activity Catalysis of the reaction: methylguanidine + H2O = methylamine + urea. MF
GO:0050099 methylglutamate dehydrogenase activity Catalysis of the reaction: N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor. MF
GO:0007317 regulation of pole plasm oskar mRNA localization Any process that modulates the frequency, rate or extent of the process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0007316 pole plasm RNA localization The processes by which RNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0007315 pole plasm assembly NA BP
GO:0007314 oocyte anterior/posterior axis determination Polarization of the oocyte along its anterior-posterior axis. BP
GO:0007313 maternal determination of dorsal/ventral axis, oocyte, soma encoded Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. BP
GO:0007312 oocyte nucleus migration during oocyte axis determination The directed movement of the oocyte nucleus within the cell during the establishment and maintenance of the axes of the oocyte. BP
GO:0007311 maternal determination of dorsal/ventral axis, oocyte, germ-line encoded Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. BP
GO:0007310 oocyte dorsal/ventral axis determination The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. BP
GO:0007319 negative regulation of oskar mRNA translation Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein. BP
GO:0007318 pole plasm protein localization The processes by which a protein is transported to, or maintained in, the oocyte pole plasm. BP
GO:0032148 activation of protein kinase B Any process that initiates the activity of the inactive enzyme protein kinase B. BP
GO:0032149 response to rhamnose stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus. BP
GO:0032142 single guanine insertion binding Interacting selectively with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine. MF
GO:0032143 single thymine insertion binding Interacting selectively with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine. MF
GO:0032140 single adenine insertion binding Interacting selectively with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine. MF
GO:0032141 single cytosine insertion binding Interacting selectively with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine. MF
GO:0032146 thiosulfate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in). MF
GO:0032147 activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase. BP
GO:0032144 4-aminobutyrate transaminase complex A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity. CC
GO:0032145 succinate-semialdehyde dehydrogenase binding Interacting selectively with succinate-semialdehyde dehydrogenase. MF
GO:0032227 negative regulation of synaptic transmission, dopaminergic Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. BP
GO:0009602 detection of symbiont The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0009601 detection of insect The series of events in which a stimulus from an insect is received and converted into a molecular signal. BP
GO:0032224 positive regulation of synaptic transmission, cholinergic Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. BP
GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. BP
GO:0007446 imaginal disc growth The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. BP
GO:0009605 response to external stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. BP
GO:0009604 detection of symbiotic bacterium The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal. BP
GO:0007449 proximal/distal pattern formation, imaginal disc The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. BP
GO:0007448 anterior/posterior pattern formation, imaginal disc The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form. BP
GO:0006198 cAMP catabolic process The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0006196 AMP catabolic process The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. BP
GO:0006194 dIDP phosphorylation The process of introducing a phosphoric group into dIDP, deoxyinosine diphosphate, to produce dITP. BP
GO:0006195 purine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0006192 IDP phosphorylation The process of introducing a phosphoric group into IDP, inosine (5'-)diphosphate, to produce ITP. BP
GO:0006193 ITP catabolic process The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate. BP
GO:0006190 inosine salvage Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis. BP
GO:0006191 deoxyinosine salvage Any process that generates deoxyinosine from derivatives of it, without de novo synthesis. BP
GO:0006738 nicotinamide riboside catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. BP
GO:0006739 NADP metabolic process The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. BP
GO:0006732 coenzyme metabolic process The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. BP
GO:0006733 oxidoreduction coenzyme metabolic process NA BP
GO:0006730 one-carbon compound metabolic process The chemical reactions and pathways involving compounds containing a single carbon atom. BP
GO:0006734 NADH metabolic process The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. BP
GO:0006735 NADH regeneration NA BP
GO:0005429 chromaffin granule amine transporter activity NA MF
GO:0005427 proton-dependent oligopeptide transporter activity NA MF
GO:0045187 regulation of circadian sleep/wake cycle, sleep Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. BP
GO:0000064 L-ornithine transporter activity Enables the directed movement of L-ornithine, 2,5-diaminopentanoic acid, into, out of, within or between cells. MF
GO:0000066 mitochondrial ornithine transport The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion. BP
GO:0000060 protein import into nucleus, translocation The vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0000061 protein import into nucleus, substrate release The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins. BP
GO:0000062 acyl-CoA binding Interacting selectively with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. MF
GO:0004778 succinyl-CoA hydrolase activity Catalysis of the reaction: succinyl-CoA + H2O = CoA + succinate. MF
GO:0004779 sulfate adenylyltransferase activity NA MF
GO:0004774 succinate-CoA ligase activity Catalysis of the reaction between succinate and CoA to form succinyl-CoA. MF
GO:0004775 succinate-CoA ligase (ADP-forming) activity Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. MF
GO:0004776 succinate-CoA ligase (GDP-forming) activity Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. MF
GO:0004777 succinate-semialdehyde dehydrogenase activity Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. MF
GO:0004770 sterol carrier protein X-related thiolase activity NA MF
GO:0004771 sterol esterase activity Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. MF
GO:0004772 sterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + cholesterol = CoA + cholesterol ester. MF
GO:0004773 steryl-sulfatase activity Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + SO4(2-) (sulfate). MF
GO:0018058 N-terminal protein amino acid deamination, from amino carbon The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol. BP
GO:0018059 N-terminal peptidyl-serine deamination NA BP
GO:0018054 peptidyl-lysine biotinylation The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine. BP
GO:0018055 peptidyl-lysine lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. BP
GO:0018057 peptidyl-lysine oxidation The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens. BP
GO:0018050 C-terminal peptidyl-threonine amidation The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein. BP
GO:0018051 C-terminal peptidyl-tryptophan amidation The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein. BP
GO:0018052 C-terminal peptidyl-tyrosine amidation The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein. BP
GO:0018053 C-terminal peptidyl-valine amidation The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein. BP
GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule. MF
GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. MF
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016905 myosin heavy chain kinase activity Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate. MF
GO:0016906 sterol 3-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol. MF
GO:0016907 G-protein coupled acetylcholine receptor activity NA MF
GO:0016908 MAP kinase 2 activity NA MF
GO:0016909 SAP kinase activity Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines. MF
GO:0051369 peptidyl-threonine decanoylation The posttranslational decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin. BP
GO:0051368 peptidyl-threonine octanoylation The posttranslational octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin. BP
GO:0051361 peptide cross-linking via L-lysine 5-imidazolinone glycine The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, an lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. BP
GO:0051360 peptide cross-linking via L-asparagine 5-imidazolinone glycine The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. BP
GO:0051363 peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. BP
GO:0051362 peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species. BP
GO:0051365 cellular response to potassium ion starvation A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of deprivation of potassium ions. BP
GO:0051364 N-terminal peptidyl-proline N-formylation The formylation of the N-terminal proline of proteins to form the derivative N-formylproline. BP
GO:0051367 peptidyl-serine decanoylation The posttranslational decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin. BP
GO:0051366 protein amino acid decanoylation The modification of a protein amino acid by formation of an ester or amide with decanoic acid. BP
GO:0042641 actomyosin Any complex of actin, myosin, and accessory proteins. CC
GO:0021638 trigeminal nerve formation The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. BP
GO:0021639 trochlear nerve morphogenesis The process by which the anatomical structure of the trochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. BP
GO:0021630 olfactory nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. BP
GO:0021631 optic nerve morphogenesis The process by which the anatomical structure of the optic nerve is generated and organized. Morphogenesis pertains to the creation of form. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. BP
GO:0021632 optic nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. BP
GO:0021633 optic nerve structural organization The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. BP
GO:0021634 optic nerve formation The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. BP
GO:0021635 trigeminal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. BP
GO:0021636 trigeminal nerve morphogenesis The process by which the anatomical structure of the trigeminal nerve is generated and organized. Morphogenesis pertains to the creation of form. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. BP
GO:0021637 trigeminal nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. BP
GO:0001858 complement component iC3b receptor activity Combining with the iC3b product of the complement cascade to initiate a change in cell activity. MF
GO:0001859 complement component C3dg receptor activity Combining with the C3dg product of the complement cascade to initiate a change in cell activity. MF
GO:0001852 complement component iC3b binding Interacting selectively with the iC3b product of the complement cascade. MF
GO:0001853 complement component C3dg binding Interacting selectively with the C3dg product of the complement cascade. MF
GO:0001850 complement component C3a binding Interacting selectively with the C3a product of the complement cascade. MF
GO:0001851 complement component C3b binding Interacting selectively with the C3b product of the complement cascade. MF
GO:0001856 complement component C5a binding Interacting selectively with the C5a product of the complement cascade. MF
GO:0001857 complement component C1q receptor activity Combining with the C1q component of the classical complement cascade to initiate a change in cell activity. MF
GO:0001854 complement component C3d binding Interacting selectively with the C3d product of the complement cascade. MF
GO:0001855 complement component C4b binding Interacting selectively with the C4b product of the classical complement cascade. MF
GO:0046000 positive regulation of ecdysteroid secretion Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid. BP
GO:0046001 negative regulation of progression through preblastoderm mitotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of progression through the preblastoderm mitotic cell cycle. BP
GO:0016274 protein-arginine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue in a protein substrate. MF
GO:0016275 [cytochrome c]-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine. MF
GO:0046004 positive regulation of progression through syncytial blastoderm mitotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the syncytial blastoderm mitotic cell cycle. BP
GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep. BP
GO:0046006 regulation of activated T cell proliferation Any process that modulates the frequency, rate or extent of activated T cell proliferation. BP
GO:0046007 negative regulation of activated T cell proliferation Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation. BP
GO:0046008 regulation of female receptivity, post-mating Any process that modulates the receptiveness of a female to male advances subsequent to mating. BP
GO:0046009 positive regulation of female receptivity, post-mating Any process that increases the receptiveness of a female to male advances subsequent to mating. BP
GO:0016278 lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. MF
GO:0016279 protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. MF
GO:0030379 neurotensin receptor activity, non-G-protein coupled NA MF
GO:0030378 serine racemase activity Catalysis of the synthesis of free D-serine from L-serine. MF
GO:0030373 high molecular weight B cell growth factor receptor activity Combining with a high molecular weight B cell growth factor to initiate a change in cell activity. MF
GO:0030372 high molecular weight B cell growth factor receptor binding Interacting selectively with the high molecular weight B cell growth factor receptor. MF
GO:0030371 translation repressor activity Antagonizes ribosome-mediated translation of mRNA into a polypeptide. MF
GO:0030370 intercellular adhesion molecule-3 receptor binding Interacting selectively with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1. MF
GO:0030377 U-plasminogen activator receptor activity NA MF
GO:0030375 thyroid hormone receptor coactivator activity NA MF
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity NA MF
GO:0047838 D-xylose 1-dehydrogenase activity Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH. MF
GO:0047839 dATP(dGTP)-DNA purinetransferase activity Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA. MF
GO:0047836 D-tryptophan N-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan. MF
GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH. MF
GO:0047834 D-threo-aldose 1-dehydrogenase activity Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH. MF
GO:0047835 D-tryptophan N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + D-tryptophan = CoA + N-acetyl-D-tryptophan. MF
GO:0047832 D-pinitol dehydrogenase activity Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH. MF
GO:0047833 D-sorbitol dehydrogenase (acceptor) activity Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor. MF
GO:0047830 D-octopine dehydrogenase activity Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH. MF
GO:0047831 D-ornithine 4,5-aminomutase activity Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate. MF
GO:0021949 brainstem precerebellar neuron precursor migration The early migration of precerebellar neuronal precursors in which cells move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem. BP
GO:0009508 plastid chromosome A circular DNA molecule containing plastid encoded genes. CC
GO:0009509 chromoplast A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments. CC
GO:0009501 amyloplast A plastid whose main function is to synthesize and store starch. CC
GO:0009502 photosynthetic electron transport chain A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen). CC
GO:0009503 light-harvesting complex (sensu Viridiplantae) A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0009504 cell plate The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells. CC
GO:0009505 cell wall (sensu Magnoliophyta) A more or less rigid membrane enclosing the protoplast of a cell and composed of cellulose and other organic and inorganic substances. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0009506 plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. CC
GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. CC
GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0032788 saturated monocarboxylic acid metabolic process The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds. BP
GO:0032789 unsaturated monocarboxylic acid metabolic process The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds. BP
GO:0032780 negative regulation of ATPase activity Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. BP
GO:0032781 positive regulation of ATPase activity Any process that activates or increases the rate of ATP hydrolysis by an ATPase. BP
GO:0032782 bile acid secretion The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or group of cells. BP
GO:0032783 ELL-EAF complex A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae. CC
GO:0032784 regulation of RNA elongation Any process that modulates the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. BP
GO:0032785 negative regulation of RNA elongation Any process that stops, prevents or reduces the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. BP
GO:0032786 positive regulation of RNA elongation Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. BP
GO:0032787 monocarboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). BP
GO:0008679 2-hydroxy-3-oxopropionate reductase activity Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+. MF
GO:0043648 dicarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). BP
GO:0008671 2-dehydro-3-deoxygalactonokinase activity Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate. MF
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+. MF
GO:0008673 2-dehydro-3-deoxygluconokinase activity Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + beta-L-arabinose 1-phosphate. MF
GO:0043642 novobiocin biosynthetic process The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. BP
GO:0043645 cephalosporin metabolic process The chemical reactions involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria. BP
GO:0008674 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. MF
GO:0008677 2-dehydropantoate 2-reductase activity Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+. MF
GO:0008676 3-deoxy-8-phosphooctulonate synthase activity Catalysis of the reaction: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. MF
GO:0045526 interleukin-26 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-26. BP
GO:0045527 interleukin-27 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-27. BP
GO:0045524 interleukin-24 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-24. BP
GO:0045525 interleukin-25 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-25. BP
GO:0045522 interleukin-26 receptor binding Interacting selectively with the interleukin-26 receptor. MF
GO:0045523 interleukin-27 receptor binding Interacting selectively with the interleukin-27 receptor. MF
GO:0045520 interleukin-24 receptor binding Interacting selectively with the interleukin-24 receptor. MF
GO:0045521 interleukin-25 receptor binding Interacting selectively with the interleukin-25 receptor. MF
GO:0045528 regulation of interleukin-24 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24. BP
GO:0045529 regulation of interleukin-25 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25. BP
GO:0047018 indole-3-acetaldehyde reductase (NADH) activity Catalysis of the reaction: NAD+ + indole-3-ethanol = NADH + H+ + indole acetaldehyde. MF
GO:0047019 indole-3-acetaldehyde reductase (NADPH) activity Catalysis of the reaction: NADP+ + indole-3-ethanol = NADPH + H+ + indole acetaldehyde. MF
GO:0042068 regulation of pteridine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine. BP
GO:0042069 regulation of catecholamine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. BP
GO:0042066 perineurial glial growth NA BP
GO:0042067 establishment of ommatidial polarity (sensu Endopterygota) The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0047012 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one. MF
GO:0047013 12-alpha-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NADP+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate = NADPH + H+ + 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate. MF
GO:0047014 glycerol-3-phosphate 1-dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + glycerol-3-phosphate = NADPH + H+ + glyceraldehyde-3-phosphate. MF
GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. MF
GO:0047016 cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one. MF
GO:0047017 prostaglandin-F synthase activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. MF
GO:0031925 pyridoxal transporter activity Enables the directed movement of pyridoxal into, out of, within or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. MF
GO:0031924 vitamin B6 transporter activity Enables the directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of, within or between cells. MF
GO:0031927 pyridoxamine transporter activity Enables the directed movement of pyridoxamine into, out of, within or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. MF
GO:0031926 pyridoxal phosphate transporter activity Enables the directed movement of pyridoxal phosphate into, out of, within or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6. MF
GO:0031921 pyridoxal phosphate transport The directed movement of pyridoxal phosphate into, out of, within or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6. BP
GO:0031920 pyridoxal transport The directed movement of pyridoxal into, out of, within or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. BP
GO:0031923 pyridoxine transport The directed movement of pyridoxine into, out of, within or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. BP
GO:0031922 pyridoxamine transport The directed movement of pyridoxamine into, out of, within or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. BP
GO:0031929 TOR signaling pathway A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. BP
GO:0031928 pyridoxine transporter activity Enables the directed movement of pyridoxine into, out of, within or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. MF
GO:0046769 virus budding from inner nuclear membrane during viral capsid re-envelopment The re-envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring an additional membrane envelope. BP
GO:0046768 virus budding from plasma membrane during viral capsid re-envelopment The re-envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring an additional membrane envelope. BP
GO:0046761 non-lytic virus budding from plasma membrane A form of viral release in which the nucleocapsid evaginates from the host plasma membrane system, resulting in envelopment of the virus without triggering cell lysis. BP
GO:0046760 non-lytic virus budding from Golgi membrane A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus without triggering cell lysis. BP
GO:0046763 virus budding from Golgi membrane The evagination of the nucleocapsid from the host Golgi membrane system, resulting in envelopment of the virus. BP
GO:0046762 non-lytic virus budding from ER membrane A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus without triggering cell lysis. BP
GO:0046765 virus budding from nuclear membrane The evagination of the nucleocapsid from the host nuclear membrane system, resulting in envelopment of the virus. BP
GO:0046764 virus budding from ER membrane The evagination of the nucleocapsid from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus. BP
GO:0046767 virus budding from plasma membrane during viral capsid envelopment The envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring a membrane envelope. BP
GO:0046766 virus budding from plasma membrane The evagination of the nucleocapsid from the host plasma membrane system, resulting in envelopment of the virus. BP
GO:0005628 prospore membrane The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. CC
GO:0005625 soluble fraction That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water. CC
GO:0005624 membrane fraction That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes. CC
GO:0005626 insoluble fraction That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water. CC
GO:0005621 bud scar Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age. CC
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. CC
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. CC
GO:0009993 oogenesis (sensu Insecta) The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0009992 cellular osmoregulation The control of the osmotic activity of the fluid in a cell. BP
GO:0009991 response to extracellular stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. BP
GO:0009990 contact guidance Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells. BP
GO:0009997 negative regulation of cardioblast cell fate specification Any process that restricts, stops or prevents a cell from specifying into a cardioblast. BP
GO:0009996 negative regulation of cell fate specification Any process that restricts, stops or prevents a cell from adopting a specific cell fate. BP
GO:0009995 soluble molecule recognition The recognition of soluble molecules in the environment. BP
GO:0009994 oocyte differentiation The process whereby a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. BP
GO:0009999 negative regulation of auditory receptor cell fate specification Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell. BP
GO:0009998 negative regulation of retinal cone cell fate specification Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell. BP
GO:0005199 structural constituent of cell wall The action of a molecule that contributes to the structural integrity of a cell wall. MF
GO:0005198 structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. MF
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). MF
GO:0004573 mannosyl-oligosaccharide glucosidase activity Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). MF
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). MF
GO:0004576 oligosaccharyl transferase activity Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. MF
GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. MF
GO:0004574 oligo-1,6-glucosidase activity Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. MF
GO:0004575 sucrose alpha-glucosidase activity Catalysis of the hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action. MF
GO:0004578 chitobiosyldiphosphodolichol beta-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol. MF
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. MF
GO:0048103 somatic stem cell division The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. BP
GO:0048102 autophagic cell death Destruction of a cell by its own lysosomal contents. This type of programmed cell death is seen when entire tissues, or parts thereof, are committed to destruction, and occurs by the formation of multiple acidic autophagic vacuoles within the doomed cells. BP
GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive. MF
GO:0048100 wing disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing. BP
GO:0048107 4-amino-3-isothiazolidinone biosynthetic process The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively. BP
GO:0048106 establishment of body bristle orientation Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction. BP
GO:0048105 establishment of body hair orientation Orientation of body hairs, actin rich projections emanating from the apical surface of each cell, such that they all point in a uniform direction. BP
GO:0048104 establishment of body hair or bristle orientation Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction. BP
GO:0048109 peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water. BP
GO:0048108 peptide cross-linking via 4-amino-3-isothiazolidinone The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue. BP
GO:0018524 acetophenone carboxylase activity Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate. MF
GO:0018525 4-hydroxybenzoyl-CoA reductase activity Catalysis of the reaction: 4-hydroxybenzoyl-CoA + acceptor = benzoyl-CoA + reduced acceptor. MF
GO:0018526 2-aminobenzoyl-CoA reductase activity Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA. MF
GO:0018527 cyclohexylamine oxidase activity Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + H2O2. MF
GO:0018520 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2. MF
GO:0018521 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity Catalysis of the reaction: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ = 3-methylcatechol + NADH + H+ + CO2. MF
GO:0018522 benzoyl-CoA reductase activity Catalysis of the reaction: benzoyl-CoA + donor-H2 + 2 ATP = cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate. MF
GO:0018523 quinoline 2-oxidoreductase activity Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor. MF
GO:0003920 GMP reductase activity Catalysis of the reaction: inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH + H+. MF
GO:0003921 GMP synthase activity Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP. MF
GO:0003922 GMP synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. MF
GO:0003923 GPI-anchor transamidase activity Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. MF
GO:0018528 iminodiacetate dehydrogenase activity Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine. MF
GO:0018529 nitrilotriacetate monooxygenase activity Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate. MF
GO:0042859 chrysobactin catabolic process The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). BP
GO:0042858 chrysobactin biosynthetic process The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). BP
GO:0042857 chrysobactin metabolic process The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). BP
GO:0042856 eugenol catabolic process The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. BP
GO:0042855 eugenol biosynthetic process The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. BP
GO:0042854 eugenol metabolic process The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil. BP
GO:0042853 L-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of L-alanine, the levorotatory isomer of 2-aminopropanoic acid. BP
GO:0042852 L-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-alanine, the levorotatory isomer of 2-aminopropanoic acid. BP
GO:0042851 L-alanine metabolic process The chemical reactions and pathways involving L-alanine, the levorotatory isomer of 2-aminopropanoic acid. BP
GO:0042850 L-sorbose catabolic process The chemical reactions and pathways resulting in the breakdown of L-sorbose, the levorotatory isomer of the ketohexose xylo-2-hexulose. BP
GO:0048091 positive regulation of female pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females. BP
GO:0048090 negative regulation of female pigmentation Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in females. BP
GO:0008934 inositol-1(or 4)-monophosphatase activity Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. MF
GO:0008935 naphthoate synthase activity Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA. MF
GO:0048095 female pigmentation Establishment of a pattern of pigment in females. BP
GO:0048094 male pigmentation Establishment of a pattern of pigment in males. BP
GO:0048097 long-term maintenance of gene activation Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term. BP
GO:0048096 chromatin-mediated maintenance of transcription Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable. BP
GO:0050353 trimethyllysine dioxygenase activity Catalysis of the reaction: N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2. MF
GO:0050352 trimethylamine-oxide aldolase activity Catalysis of the reaction: (CH3)3NO = (CH3)2NH + formaldehyde. MF
GO:0050351 trimetaphosphatase activity Catalysis of the reaction: trimetaphosphate + H2O = triphosphate. MF
GO:0050350 trihydroxystilbene synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. MF
GO:0050357 tropinesterase activity Catalysis of the reaction: atropine + H2O = tropine + tropate. MF
GO:0050356 tropine dehydrogenase activity Catalysis of the reaction: tropine + NADP+ = tropinone + NADPH. MF
GO:0050355 triphosphatase activity Catalysis of the reaction: triphosphate + H2O = diphosphate + phosphate. MF
GO:0050354 triokinase activity Catalysis of the reaction: ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate. MF
GO:0050359 tropomyosin kinase activity Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin. MF
GO:0050358 tropinone reductase activity Catalysis of the reaction: pseudotropine + NADP+ = tropinone + NADPH. MF
GO:0051750 delta3,5-delta2,4-dienoyl-CoA isomerase activity Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA. MF
GO:0051751 alpha-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,4-linkage. MF
GO:0051752 phosphoglucan, water dikinase activity Catalysis of the reaction: ATP + glucan-phosphate(n) + H2O = AMP + glucan-phosphate(n+1) + phosphate. MF
GO:0051753 mannan synthase activity Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-1,4-linked mannan backbone in substrates such as galactomannan. MF
GO:0051754 meiotic sister chromatid cohesion, centromeric The cell cycle process whereby centromeres of sister chromatids are joined during meiosis. BP
GO:0051755 meiotic sister chromatid arm separation The cell cycle process whereby sister chromatid arms are physically detached from each other during meiosis. BP
GO:0051756 meiotic sister chromatid centromere separation The cell cycle process whereby the centromeres of sister chromatids are physically detached from each other during meiosis. BP
GO:0051757 meiotic sister chromatid separation The process by which sister chromatids are physically detached from each other during meiosis. BP
GO:0051758 homologous chromosome movement towards spindle pole during meiosis I The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I. BP
GO:0051759 sister chromosome movement towards spindle pole during meiosis II The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II. BP
GO:0007124 pseudohyphal growth A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate. BP
GO:0007126 meiosis Progression through meiosis, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiosis occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations. BP
GO:0007127 meiosis I Progression through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells. BP
GO:0007120 axial bud site selection The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell. BP
GO:0007121 bipolar bud site selection The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell. BP
GO:0007128 meiotic prophase I Progression through prophase of meiosis I; divided into several stages. BP
GO:0007129 synapsis The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate. BP
GO:0051428 peptide hormone receptor binding Interacting selectively with a receptor for peptide hormones. MF
GO:0051429 corticotropin-releasing hormone receptor binding Interacting selectively with a receptor for corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. MF
GO:0052221 positive chemotaxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052220 positive aerotaxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052223 negative chemotaxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052222 negative aerotaxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052225 energy taxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052224 energy taxis within other organism during symbiotic interaction The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052227 catabolism of substance in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction. BP
GO:0052226 biosynthesis of substance in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction. BP
GO:0052229 metabolism of macromolecule in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052228 metabolism by symbiont of host protein The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0005785 signal recognition particle receptor complex A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex. CC
GO:0010313 phytochrome binding Interacting selectively with phytochrome. MF
GO:0010312 detoxification of zinc ion The processes that reduce or remove the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion. BP
GO:0010311 lateral root formation The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0010310 regulation of hydrogen peroxide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions involving hydrogen peroxide. BP
GO:0010317 pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. CC
GO:0010316 pyrophosphate-dependent phosphofructokinase complex Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate. CC
GO:0010315 auxin efflux The process involved in the transport of auxin out of the cell. BP
GO:0010314 phosphatidylinositol-5-phosphate binding Interacting selectively with phosphatidylinositol-5-phosphate, a phosphorylated derivative of phosphatidylinositol. MF
GO:0010319 stromule Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types. CC
GO:0010318 pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. CC
GO:0032810 sterol response element binding Interacting selectively with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism. MF
GO:0032811 negative regulation of epinephrine secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of epinephrine. BP
GO:0032812 positive regulation of epinephrine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine. BP
GO:0032813 tumor necrosis factor receptor superfamily binding Interacting selectively with any member of the tumor necrosis factor receptor superfamily. MF
GO:0032814 regulation of natural killer cell activation Any process that modulates the frequency, rate or extent of natural killer cell activation. BP
GO:0032815 negative regulation of natural killer cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. BP
GO:0032816 positive regulation of natural killer cell activation Any process that activates or increases the frequency, rate or extent of natural killer cell activation. BP
GO:0032817 regulation of natural killer cell proliferation Any process that modulates the frequency, rate or extent of natural killer cell proliferation. BP
GO:0032818 negative regulation of natural killer cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation. BP
GO:0032819 positive regulation of natural killer cell proliferation Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation. BP
GO:0031861 prolactin-releasing peptide receptor binding Interacting selectively with a prolactin-releasing peptide receptor. MF
GO:0015448 type III protein (virulence-related) secretor activity NA MF
GO:0015449 type IV protein (DNA-protein) secretor activity NA MF
GO:0015444 magnesium-importing ATPase activity Catalysis of the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). MF
GO:0015445 silver-exporting ATPase activity Catalysis of the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out). MF
GO:0015446 arsenite-transporting ATPase activity Catalysis of the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). MF
GO:0015447 type II protein secretor activity NA MF
GO:0015440 peptide-transporting ATPase activity Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria. MF
GO:0015441 beta-glucan-transporting ATPase activity Catalysis of the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out). MF
GO:0047560 3-dehydrosphinganine reductase activity Catalysis of the reaction: sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+. MF
GO:0047561 3-hydroxyanthranilate oxidase activity Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2. MF
GO:0047562 3-hydroxyaspartate aldolase activity Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = glycine + glyoxylate. MF
GO:0047563 3-hydroxybenzoate 2-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + donor-H2 + O2 = 2,3-dihydroxybenzoate + acceptor + H2O. MF
GO:0047564 3-hydroxycyclohexanone dehydrogenase activity Catalysis of the reaction: 3-hydroxycyclohexanone + acceptor = cyclohexane-1,3-dione + reduced acceptor. MF
GO:0047565 3-hydroxypropionate dehydrogenase activity Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+. MF
GO:0047566 3-ketovalidoxylamine C-N-lyase activity Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one. MF
GO:0047567 3-methyleneoxindole reductase activity Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + NADPH + H+. MF
GO:0047568 3-oxo-5-beta-steroid 4-dehydrogenase activity Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor. MF
GO:0047569 3-oxoadipate CoA-transferase activity Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. MF
GO:0043270 positive regulation of ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells. BP
GO:0043271 negative regulation of ion transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells. BP
GO:0043272 ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring during the process of jasmonic acid and ethylene-dependent systemic resistance. BP
GO:0043273 CTPase activity Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction. MF
GO:0043274 phospholipase binding Interacting selectively with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. MF
GO:0043275 glutamate carboxypeptidase II activity Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu. MF
GO:0043276 anoikis Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix. BP
GO:0043277 apoptotic cell clearance The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. BP
GO:0043278 response to morphine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. BP
GO:0043279 response to alkaloid A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. BP
GO:0005764 lysosome Any of a group of related cytoplasmic, membrane bound organelles that are found in most animal cells and that contain a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. CC
GO:0005765 lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. CC
GO:0048916 posterior lateral line development The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear. BP
GO:0048917 posterior lateral line ganglion development The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear. BP
GO:0048910 afferent axon development in the anterior lateral line nerve The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve. BP
GO:0005761 mitochondrial ribosome A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. CC
GO:0048912 glial cell migration in the anterior lateral line nerve The movement of glial cells along the axons in the anterior lateral line nerve. BP
GO:0005763 mitochondrial small ribosomal subunit The smaller of the two subunits of a mitochondrial ribosome. CC
GO:0046211 (+)-camphor biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone. BP
GO:0046210 nitric oxide catabolic process The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. BP
GO:0046213 methyl ethyl ketone catabolic process The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. BP
GO:0046215 siderophore catabolic process The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. BP
GO:0046214 enterobactin catabolic process The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. BP
GO:0046217 indole phytoalexin metabolic process The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response. BP
GO:0046216 indole phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response. BP
GO:0046219 indolalkylamine biosynthetic process The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. BP
GO:0046218 indolalkylamine catabolic process The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. BP
GO:0005768 endosome A membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation. CC
GO:0048919 posterior lateral line neuromast development The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. BP
GO:0030508 thiol-disulfide exchange intermediate activity Functions as an exchange intermediate in thiol-disulfide exchange reactions. MF
GO:0030509 BMP signaling pathway A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor. BP
GO:0030500 regulation of bone mineralization Any process that modulates the frequency, rate or extent of bone mineralization. BP
GO:0030501 positive regulation of bone mineralization Any process that activates or increases the frequency, rate or extent of bone mineralization. BP
GO:0030502 negative regulation of bone mineralization Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization. BP
GO:0030503 regulation of cell redox homeostasis Any process that modulates the redox environment of a cell or compartment within a cell. BP
GO:0030504 inorganic diphosphate transporter activity Catalysis of the transfer of inorganic diphosphate across a membrane. MF
GO:0030505 inorganic diphosphate transport The directed movement of inorganic diphosphate into, out of, within or between cells. BP
GO:0030506 ankyrin binding Interacting selectively with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. MF
GO:0030507 spectrin binding Interacting selectively with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. MF
GO:0007618 mating The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. BP
GO:0007619 courtship behavior The actions or reactions of individuals for the purpose of attracting a sexual partner. BP
GO:0007612 learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. BP
GO:0007613 memory The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). BP
GO:0031679 NADH dehydrogenase (plastoquinone) activity Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol. MF
GO:0031678 NADH dehydrogenase complex (plastoquinone) (sensu CyanoBacteria) Complex that possesses NADH dehydrogenase (plastoquinone) activity, as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117). CC
GO:0031671 primary cell septum biogenesis The chemical reactions and pathways resulting in the formation of the constituents of the primary cell septum following nuclear division. BP
GO:0031670 cellular response to nutrient A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. BP
GO:0031673 H zone A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments. CC
GO:0031672 A band The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. CC
GO:0031675 NADH dehydrogenase complex (plastoquinone) Complex that possesses NADH dehydrogenase (plastoquinone) activity. CC
GO:0031674 I band A region of a sarcomere that appears as a light band on each side of the Z line, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. CC
GO:0031677 plastid NADH dehydrogenase complex (plastoquinone) A NADH dehydrogenase complex (plastoquinone) complex found in a plastid. CC
GO:0031676 thylakoid membrane (sensu CyanoBacteria) The pigmented membrane of a thylakoid. As in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117). CC
GO:0050575 2-(S)-hydroxypropyl-CoM dehydrogenase activity Catalysis of the reaction: 2-(S)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+. MF
GO:0002899 negative regulation of central B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion. BP
GO:0002898 regulation of central B cell deletion Any process that modulates the frequency, rate, or extent of central B cell deletion. BP
GO:0002897 positive regulation of central B cell tolerance induction Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction. BP
GO:0002896 negative regulation of central B cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction. BP
GO:0002895 regulation of central B cell tolerance induction Any process that modulates the frequency, rate, or extent of central B cell tolerance induction. BP
GO:0002894 positive regulation of type II hypersensitivity Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity. BP
GO:0002893 negative regulation of type II hypersensitivity Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity. BP
GO:0002892 regulation of type II hypersensitivity Any process that modulates the frequency, rate, or extent of type II hypersensitivity. BP
GO:0002891 positive regulation of immunoglobulin mediated immune response Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. BP
GO:0002890 negative regulation of immunoglobulin mediated immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response. BP
GO:0009719 response to endogenous stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus. BP
GO:0009718 anthocyanin biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. BP
GO:0032379 positive regulation of intracellular lipid transport Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. BP
GO:0032378 negative regulation of intracellular lipid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. BP
GO:0009711 purine alkaloid biosynthetic process The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure. BP
GO:0009710 tropane alkaloid biosynthetic process The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. BP
GO:0009713 catechol biosynthetic process The chemical reactions and pathways resulting in the formation of catechol, a compound containing a pyrocatechol nucleus or substituent. BP
GO:0009712 catechol metabolic process The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. BP
GO:0032371 regulation of sterol transport Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells. BP
GO:0009714 chalcone metabolic process The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives. BP
GO:0009717 isoflavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. BP
GO:0009716 flavonoid phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. BP
GO:0019949 SUMO conjugating enzyme activity Catalysis of the covalent attachment of the ubiquitin-like protein SUMO to other proteins. MF
GO:0019948 SUMO activating enzyme activity Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. BP
GO:0030993 axonemal heterotrimeric kinesin-II complex A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme. CC
GO:0030992 intraflagellar transport particle B The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa. CC
GO:0030991 intraflagellar transport particle A The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa. CC
GO:0030990 intraflagellar transport particle A nonmembrane-bound oliogmeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. CC
GO:0030997 regulation of centriole-centriole cohesion Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker. BP
GO:0030996 cell cycle arrest in response to nitrogen starvation The processes that lead to a halt in cell cycle progression (cessation of cell cycle transitions) as a result of deprivation of nitrogen. BP
GO:0030995 cell septum edging catabolic process Dissolution of the septum edging during cell separation. BP
GO:0030994 primary cell septum diassembly Dissolution of the primary septum during cell separation. BP
GO:0030999 linear element formation The cell cycle process whereby a proteinaceous scaffold, related to the synaptonemal complex, is formed in association with S. pombe chromosomes during meiotic prophase. BP
GO:0030998 linear element A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex. CC
GO:0042185 m-xylene catabolic process The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon. BP
GO:0042184 xylene catabolic process The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. BP
GO:0042187 p-xylene catabolic process The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon. BP
GO:0042186 o-xylene catabolic process The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. BP
GO:0042181 ketone biosynthetic process The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. BP
GO:0042180 ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. BP
GO:0042183 formate catabolic process The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. BP
GO:0042182 ketone catabolic process The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. BP
GO:0042189 vanillin biosynthetic process The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods. BP
GO:0042188 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. BP
GO:0047609 acetylputrescine deacetylase activity Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine. MF
GO:0047608 acetylindoxyl oxidase activity Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown. MF
GO:0042239 interleukin-22 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-22. BP
GO:0042238 interleukin-21 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-21. BP
GO:0047601 acetate kinase (diphosphate) activity Catalysis of the reaction: diphosphate + acetate = phosphate + acetyl phosphate. MF
GO:0047600 abequosyltransferase activity Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid. MF
GO:0047603 acetoacetyl-CoA hydrolase activity Catalysis of the reaction: acetoacetyl-CoA + H2O = CoA + acetoacetate. MF
GO:0047602 acetoacetate decarboxylase activity Catalysis of the reaction: acetoacetate + H+ = acetone + CO2. MF
GO:0047605 acetolactate decarboxylase activity Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2. MF
GO:0047604 acetoin racemase activity Catalysis of the reaction: (S)-acetoin = (R)-acetoin. MF
GO:0042231 interleukin-13 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-13. BP
GO:0042230 interleukin-11 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-11. BP
GO:0006549 isoleucine metabolic process The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. BP
GO:0006548 histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. BP
GO:0003718 RNA polymerase III transcription termination factor activity Any activity that brings about termination of transcription by RNA polymerase III. MF
GO:0003717 RNA polymerase II transcription termination factor activity Any activity that brings about termination of transcription by RNA polymerase II. MF
GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. BP
GO:0006547 histidine metabolic process The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. BP
GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. BP
GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. BP
GO:0003712 transcription cofactor activity The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. MF
GO:0006543 glutamine catabolic process The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid. BP
GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. BP
GO:0000257 nitrilase activity Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. MF
GO:0000256 allantoin catabolic process The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. BP
GO:0000255 allantoin metabolic process The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. BP
GO:0000254 C-4 methylsterol oxidase activity Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O. MF
GO:0000253 3-keto sterol reductase activity Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+. MF
GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. MF
GO:0000250 lanosterol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. MF
GO:0004947 bradykinin receptor activity Combining with bradykinin to initiate a change in cell activity. MF
GO:0004946 bombesin receptor activity Combining with bombesin to initiate a change in cell activity. MF
GO:0004945 angiotensin type II receptor activity NA MF
GO:0004944 C5a anaphylatoxin receptor activity Combining with anaphylatoxin C5a to initiate a change in cell activity. MF
GO:0004943 C3a anaphylatoxin receptor activity Combining with anaphylatoxin C3a to initiate a change in cell activity. MF
GO:0004942 anaphylatoxin receptor activity Combining with anaphylatoxin to initiate a change in cell activity. MF
GO:0004941 beta2-adrenergic receptor activity NA MF
GO:0004940 beta1-adrenergic receptor activity NA MF
GO:0005222 intracellular cAMP activated cation channel activity NA MF
GO:0004949 cannabinoid receptor activity Combining with cannabinoids to initiate a change in cell activity. MF
GO:0004948 calcitonin receptor activity Combining with calcitonin to initiate a change in cell activity. MF
GO:0005225 volume-sensitive anion channel activity NA MF
GO:0007436 larval salivary gland morphogenesis The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048802 notum morphogenesis The process by which the anatomical structures of dorsal part of the body are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048803 male genitalia morphogenesis (sensu Endopterygota) The process by which the anatomical structures of male genitalia are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048800 antennal morphogenesis The process by which the anatomical structures of antenna are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048801 antennal joint morphogenesis The process by which the anatomical structures of the antennal joint are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0002048 pyoverdine metabolic process The chemical reactions and pathways involving the siderochrome pyoverdine. BP
GO:0005017 platelet-derived growth factor receptor activity Combining with platelet-derived growth factor to initiate a change in cell activity. MF
GO:0048804 female genitalia morphogenesis (sensu Endopterygota) The process by which the anatomical structures of female genitalia are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048805 genitalia morphogenesis (sensu Endopterygota) The process by which the anatomical structures of genitalia are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0002044 blood vessel endothelial cell migration during intussusceptive angiogenesis The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis. BP
GO:0002045 regulation of cell adhesion during intussusceptive angiogenesis The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix during intussusceptive angiogenesis. BP
GO:0048808 male genitalia morphogenesis The process by which the anatomical structures of male genitalia are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0005019 platelet-derived growth factor beta-receptor activity NA MF
GO:0002040 sprouting angiogenesis The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. BP
GO:0002041 intussusceptive angiogenesis The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars. BP
GO:0002042 cell migration during sprouting angiogenesis The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during sprouting angiogenesis. BP
GO:0002043 blood vessel endothelial cell proliferation during sprouting angiogenesis The multiplication or reproduction of blood vessel endothelial cells, resulting in the rapid expansion of a cell population during sprouting angiogenesis. BP
GO:0051130 positive regulation of cell organization and biogenesis Any process that activates or increases the frequency, rate or extent of the processes involved in the assembly and arrangement of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. BP
GO:0051131 chaperone-mediated protein complex assembly The aggregation and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. BP
GO:0051132 NK T cell activation The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. BP
GO:0051133 regulation of NK T cell activation Any process that modulates the frequency, rate or extent of natural killer T cell activation. BP
GO:0051134 negative regulation of NK T cell activation Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell activation. BP
GO:0051135 positive regulation of NK T cell activation Any process that activates or increases the frequency, rate or extent of natural killer T cell activation. BP
GO:0051136 regulation of NK T cell differentiation Any process that modulates the frequency, rate or extent of natural killer T cell differentiation. BP
GO:0051137 negative regulation of NK T cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell differentiation. BP
GO:0051138 positive regulation of NK T cell differentiation Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation. BP
GO:0051139 metal ion:hydrogen antiporter activity Catalysis of the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). MF
GO:0010010 lysine-ketoglutarate reductase activity Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+. MF
GO:0010011 auxin binding Interacting selectively with auxin, plant hormones that regulate aspects of plant growth. MF
GO:0010012 steroid 22-alpha hydroxylase activity Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O. MF
GO:0010013 N-1-naphthylphthalamic acid binding Interacting selectively with N-1-naphthylphthalamic acid, an auxin transport inhibitor. MF
GO:0010014 meristem initiation Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. BP
GO:0010015 root morphogenesis The process by which the anatomical structures of roots are generated and organized. Morphogenesis pertains to the creation of form. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support. BP
GO:0010016 shoot morphogenesis The process by which the anatomical structures of the shoot are generated and organized. Morphogenesis pertains to the creation of form. The shoot is the part of a seed plant body that is usually above ground. BP
GO:0010017 red or far red light signaling pathway The series of molecular signals initiated upon sensing by photoreceptor molecules of red light at 660nm or far red light at 730nm. BP
GO:0010018 far red light signaling pathway The series of molecular signals initiated upon sensing of far red light by photoreceptor molecule at 730 nm. BP
GO:0010019 chloroplast-nucleus signaling pathway The process by which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis. BP
GO:0018227 peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine. BP
GO:0018226 peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic. BP
GO:0018222 peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine The, presumably, posttranslational modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide. BP
GO:0018221 peptidyl-serine palmitoylation The palmitoylation of peptidyl-serine to form peptidyl-O-palmitoyl-L-threonine. BP
GO:0018220 peptidyl-threonine palmitoylation The palmitoylation of peptidyl-threonine to form peptidyl-O-palmitoyl-L-threonine. BP
GO:0018229 peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl ester. BP
GO:0018228 peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification. BP
GO:0009620 response to fungus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. BP
GO:0004055 argininosuccinate synthase activity Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (Nw-L-arginino)succinate. MF
GO:0004054 arginine kinase activity Catalysis of the reaction: ATP + L-arginine = ADP + N-phospho-L-arginine. MF
GO:0004057 arginyltransferase activity Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein. MF
GO:0004056 argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. MF
GO:0004051 arachidonate 5-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. MF
GO:0004053 arginase activity Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. MF
GO:0004052 arachidonate 12-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. MF
GO:0004059 aralkylamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine. MF
GO:0004058 aromatic-L-amino-acid decarboxylase activity Catalysis of the reaction: L-tryptophan = tryptamine + CO2. MF
GO:0007432 salivary gland boundary specification Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. BP
GO:0001669 acrosome A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plama membrane and is derived from the lysosome. CC
GO:0001668 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidylinositol-4,5-bisphosphate + H2O = phosphatidyl inositol-4-phosphate + phosphate. MF
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein. MF
GO:0001664 G-protein-coupled receptor binding Interacting selectively with a G-protein-coupled receptor. MF
GO:0001667 ameboidal cell migration Cell migration that is accomplished by extension and retraction of a pseudopodium. BP
GO:0001666 response to hypoxia A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. BP
GO:0001661 conditioned taste aversion A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus. BP
GO:0001660 fever A rise in body temperature above the normal, often as a response to infection. BP
GO:0001662 behavioral fear response An acute behavioral change resulting from a perceived external threat. BP
GO:0007433 larval salivary gland determination Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. BP
GO:0051329 interphase of mitotic cell cycle Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. BP
GO:0052441 modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0018482 4-formylbenzenesulfonate dehydrogenase activity Catalysis of the reaction: 4-formylbenzenesulfonate + NAD+ + H2O = 4-sulfobenzoate + NADH + H+. MF
GO:0052443 modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0018480 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+. MF
GO:0052445 modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0018486 2-butanone oxidase activity Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate. MF
GO:0018485 salicylaldehyde dehydrogenase activity Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+. MF
GO:0018484 4-hydroxybenzaldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+. MF
GO:0052449 modulation by organism of ethylene levels in other organism during symbiotic interaction The alteration by an organism of the levels of ethylene in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0018489 vanillate monooxygenase activity Catalysis of the reaction: vanillate + O2 + NADH + H+ = 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde. MF
GO:0018488 aryl-aldehyde oxidase activity Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + H2O2. MF
GO:0007431 salivary gland development The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. BP
GO:0019574 sucrose catabolic process, using glucoside 3-dehydrogenase The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13). BP
GO:0019575 sucrose catabolic process, using beta-fructofuranosidase The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26). BP
GO:0019576 aerobic fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen. BP
GO:0042959 alkanesulfonate transporter activity Enables the directed movement of alkanesulfonate into, out of, within or between cells. MF
GO:0019570 L-arabinose catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate. BP
GO:0019571 D-arabinose catabolic process The chemical reactions and pathways resulting in the breakdown of D-arabinose, the dextrorotatory isomer of arabino-pentose. BP
GO:0019572 L-arabinose catabolic process The chemical reactions and pathways resulting in the breakdown of L-arabinose, the levorotatory isomer of arabino-pentose. BP
GO:0019573 D-arabinose catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate. BP
GO:0042952 beta-ketoadipate pathway A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. BP
GO:0042953 lipoprotein transport The directed movement of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids, into, out of, within or between cells. BP
GO:0042950 salicin transporter activity Enables the directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of, within or between cells. MF
GO:0042951 arbutin transporter activity Enables the directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of, within or between cells. MF
GO:0019578 aldaric acid biosynthetic process The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. BP
GO:0019579 aldaric acid catabolic process The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. BP
GO:0042954 lipoprotein transporter activity Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids, into, out of, within or between cells. MF
GO:0042955 dextrin transport The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of, within or between cells. BP
GO:0019688 purine deoxyribonucleoside interconversion NA BP
GO:0019689 pyrimidine nucleoside interconversion NA BP
GO:0019686 purine nucleoside interconversion NA BP
GO:0019687 pyruvate biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate. BP
GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. BP
GO:0019685 photosynthesis, dark reaction A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions. BP
GO:0019682 glyceraldehyde-3-phosphate metabolic process The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. BP
GO:0019683 glyceraldehyde-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis. BP
GO:0019680 L-methylmalonyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the levorotatory isomer of 2-carboxypropanoyl-CoA. BP
GO:0019681 acetyl-CoA assimilation pathway The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell. BP
GO:0005838 proteasome regulatory particle (sensu Eukaryota) A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0005839 proteasome core complex (sensu Eukaryota) A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. This complex is involved in the proteolysis of substrates in an ATP dependent manner and consists of four ring-like structures, two outer and two inner, each containing seven subunits. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0051499 D-aminoacyl-tRNA deacylase activity Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA. MF
GO:0051498 syn-copalyl diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = syn-copalyl diphosphate. MF
GO:0005834 heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. CC
GO:0005835 fatty acid synthase complex A multienzyme complex required to convert carbohydrates to fatty acids, specifically acetyl CoA to palmitate. CC
GO:0005836 fatty-acyl-CoA synthase complex NA CC
GO:0051494 negative regulation of cytoskeleton organization and biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of the assembly and arrangement of cytoskeletal structures. BP
GO:0005830 cytosolic ribosome (sensu Eukaryota) A ribosome found in the cytosol; this term can also be used to refer to ribosomes associated with the endoplasmic reticulum in eukaryotic cells. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0005831 steroid hormone aporeceptor complex NA CC
GO:0051491 positive regulation of filopodium formation Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. BP
GO:0005833 hemoglobin complex An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. CC
GO:0007083 mitotic chromosome decondensation The cell cycle process whereby chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells. BP
GO:0007080 mitotic metaphase plate congression The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. BP
GO:0007087 mitotic nuclear pore complex reassembly The cell cycle process whereby nuclear pore complexes reform during mitotic cell division. BP
GO:0007086 vesicle fusion with nuclear membrane The cell cycle process whereby the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus occurs. BP
GO:0007084 mitotic nuclear envelope reassembly The cell cycle process whereby the nuclear envelope reforms during mitotic cell division. BP
GO:0007089 traversing start control point of mitotic cell cycle Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle. BP
GO:0007088 regulation of mitosis Any process that modulates the frequency, rate or extent of mitosis. BP
GO:0015840 urea transport The directed movement into, out of or within the cell of urea, the water-soluble compound H2N-CO-NH2, produced in the liver via the ornithine-urea cycle. BP
GO:0015841 chromaffin granule amine transport NA BP
GO:0015842 synaptic vesicle amine transport The directed movement of amines into, out of or within synaptic vesicles. BP
GO:0015843 methylammonium transport The directed movement of methylammonium into, out of, within or between cells. BP
GO:0015844 monoamine transport The directed movement of monoamines, organic compounds containing one amino group, into, out of, within or between cells. BP
GO:0015846 polyamine transport The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of, within or between cells. BP
GO:0015847 putrescine transport The directed movement of putrescine into, out of, within or between cells. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. BP
GO:0015848 spermidine transport The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of, within or between cells. BP
GO:0015849 organic acid transport The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells. BP
GO:0007576 nucleolar fragmentation NA BP
GO:0006028 galactosaminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose. BP
GO:0006029 proteoglycan metabolic process The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. BP
GO:0006022 aminoglycan metabolic process The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. BP
GO:0006023 aminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. BP
GO:0006020 myo-inositol metabolic process The chemical reactions and pathways involving myo-inositol, 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. BP
GO:0006021 myo-inositol biosynthetic process The chemical reactions and pathways resulting in the formation of myo-inositol, 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. BP
GO:0006026 aminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. BP
GO:0006027 glycosaminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. BP
GO:0006024 glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. BP
GO:0006025 galactosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose. BP
GO:0008020 G-protein coupled photoreceptor activity A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. MF
GO:0008021 synaptic vesicle Secretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. CC
GO:0008022 protein C-terminus binding Interacting selectively with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. MF
GO:0008023 transcription elongation factor complex Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. CC
GO:0008024 transcription elongation factor complex b A complex of cyclin T and a cyclin-dependent protein kinase, catalyst, that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. CC
GO:0008026 ATP-dependent helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. MF
GO:0008028 monocarboxylic acid transporter activity Enables the directed movement of monocarboxylic acids into, out of, within or between cells. A monocarboxylic acid is an organic acid with one COOH group. MF
GO:0008029 pentraxin receptor activity Combining with a pentraxin to initiate a change in cell activity. MF
GO:0005201 extracellular matrix structural constituent The action of a molecule that contributes to the structural integrity of the extracellular matrix. MF
GO:0048610 reproductive cellular process A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism. BP
GO:0032215 positive regulation of telomere maintenance via semi-conservative replication Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA. BP
GO:0044008 dissemination or transmission of symbiont from host by vector The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044009 viral transmission by vector The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection. BP
GO:0044006 induction by symbiont in host of tumor, nodule, or growth containing transformed cells The process by which an organism causes the formation in its host organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044007 dissemination or transmission of symbiont from host The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044004 disruption by symbiont of host cells Any process by which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044005 induction by symbiont in host of tumor, nodule, or growth The process by which an organism causes the formation of an abnormal mass of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044002 acquisition of nutrients from host The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044003 modification of host morphology or physiology The process by which an organism effects a change in the structure or processes of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044000 movement within host The process by which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044001 migration within host The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0046530 photoreceptor cell differentiation The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. BP
GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. BP
GO:0046532 regulation of photoreceptor cell differentiation Any process that modulates the frequency, rate or extent of photoreceptor differentiation. BP
GO:0046533 negative regulation of photoreceptor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of photoreceptor differentiation. BP
GO:0016562 protein import into peroxisome matrix, receptor recycling The process by which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol. BP
GO:0046535 detection of chemical stimulus during sensory perception of umami taste The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. BP
GO:0016560 protein import into peroxisome matrix, docking The process by which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the preoxisomal membrane. BP
GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate without requiring the cofactor 2,3-bisphosphoglycerate. MF
GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; requires the cofactor 2,3-bisphosphoglycerate. MF
GO:0046539 histamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Nt-methylhistamine. MF
GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. BP
GO:0016569 covalent chromatin modification The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. BP
GO:0045841 negative regulation of mitotic metaphase/anaphase transition Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition. BP
GO:0045840 positive regulation of mitosis Any process that activates or increases the frequency, rate or extent of mitosis. BP
GO:0045843 negative regulation of striated muscle development Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle development. BP
GO:0045842 positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition. BP
GO:0045844 positive regulation of striated muscle development Any process that activates or increases the frequency, rate or extent of striated muscle development. BP
GO:0045847 negative regulation of nitrogen utilization Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen utilization. BP
GO:0045849 negative regulation of nurse cell apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of nurse cell apoptosis. BP
GO:0045848 positive regulation of nitrogen utilization Any process that activates or increases the frequency, rate or extent of nitrogen utilization. BP
GO:0046398 UDP-glucuronate metabolic process The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. BP
GO:0046399 glucuronate biosynthetic process The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid. BP
GO:0046394 carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. BP
GO:0046395 carboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. BP
GO:0046396 D-galacturonate metabolic process The chemical reactions and pathways involving D-galacturonate, the dextrorotatory isomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls. BP
GO:0046397 galacturonate catabolic process The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid. BP
GO:0046390 ribose phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar. BP
GO:0046391 5-phosphoribose 1-diphosphate metabolic process The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. BP
GO:0046392 galactarate catabolic process The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid. BP
GO:0046393 D-galactarate metabolic process The chemical reactions and pathways involving D-galactarate, the dextrorotatory isomer of galactarate, the anion of galactaric acid. BP
GO:0009038 undecaprenol kinase activity Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate. MF
GO:0009039 urease activity Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. MF
GO:0009030 thiamin phosphate kinase activity Catalysis of the reaction: ATP + thiamin phosphate = ADP + thiamin diphosphate. MF
GO:0009032 thymidine phosphorylase activity Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. MF
GO:0009033 trimethylamine-N-oxide reductase activity Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O. MF
GO:0009034 tryptophanase activity Catalysis of the reaction: L-tryptophan + H2O = indole + pyruvate + NH3. MF
GO:0009035 Type I site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. MF
GO:0009036 Type II site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. MF
GO:0009037 tyrosine-based site-specific recombinase activity Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site. MF
GO:0030719 polar granule organization and biogenesis The assembly and arrangement of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes. BP
GO:0030718 germ-line stem cell maintenance The processes involved in preventing uncommitted germ-line stem cells from differentiating as another cell type. BP
GO:0030711 positive regulation of border follicle cell delamination Any process that increases the frequency, rate or extent of border cell delamination. BP
GO:0030710 regulation of border follicle cell delamination Any process that regulates the frequency, rate or extent of border cell delamination. BP
GO:0030713 stalk formation (sensu Insecta) Differentiation of follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030712 negative regulation of border follicle cell delamination Any process that decreases the frequency, rate or extent of border cell delamination. BP
GO:0030715 oocyte growth (sensu Insecta) The increase in volume of an oocyte during the growth phase of the egg chamber. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030714 anterior/posterior axis determination, follicular epithelium Polarization of the follicle cells of an insect ovary along the anterior/posterior axis. BP
GO:0030717 karyosome formation Condensation of DNA in the oocyte nucleus into a compact spherical structure called the karyosome. BP
GO:0030716 oocyte fate determination Process by which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0018979 trichloroethylene metabolic process The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent. BP
GO:0018978 anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen. BP
GO:0018973 trinitrotoluene metabolic process The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene. BP
GO:0018972 toluene-4-sulfonate metabolic process The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water. BP
GO:0018971 anaerobic toluene metabolic process The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen. BP
GO:0018970 toluene metabolic process The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications. BP
GO:0018977 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. BP
GO:0018976 1,2,3-tribromopropane metabolic process The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture. BP
GO:0018975 anaerobic 2,4,6-trinitrotoluene metabolic process The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen. BP
GO:0018974 2,4,6-trinitrotoluene metabolic process The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives. BP
GO:0008349 MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. MF
GO:0008348 negative regulation of antimicrobial humoral response Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response. BP
GO:0008340 determination of adult life span The control of viability and duration in the adult phase of the life-cycle. BP
GO:0008343 adult feeding behavior Feeding behavior in a fully developed and mature organism. BP
GO:0008345 larval locomotory behavior Locomotory behavior in a larval (immature) organism. BP
GO:0008344 adult locomotory behavior Locomotory behavior in a fully developed and mature organism. BP
GO:0008347 glial cell migration The orderly movement of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. BP
GO:0008346 larval walking behavior The actions or reactions of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. BP
GO:0040024 dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. BP
GO:0040025 vulval development (sensu Nematoda) The process whose specific outcome is the progression of the vulva over time, from its formation to the mature structure. Vulval development begins during the larval stages to give rise to a fully formed vulva in the adult. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040026 positive regulation of vulval development (sensu Nematoda) Any process that activates or increases the frequency, rate or extent of development of the vulva, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040027 negative regulation of vulval development (sensu Nematoda) Any process that stops, prevents or reduces the frequency, rate or extent of development of the vulva, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040020 regulation of meiosis Any process that modulates the frequency, rate or extent of meiosis, the process by which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. BP
GO:0040021 hermaphrodite germ-line sex determination The determination of sex and sexual phenotype in the germ line of a hermaphrodite. BP
GO:0040022 feminization of hermaphroditic germ-line (sensu Nematoda) The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040023 establishment of nucleus localization The directed movement of the nucleus to a specific location within a cell. BP
GO:0040028 regulation of vulval development (sensu Nematoda) Any process that modulates the frequency, rate or extent of development of the vulva. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040029 regulation of gene expression, epigenetic Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. BP
GO:0001589 dopamine D5 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors. MF
GO:0015235 cobalamin transporter activity Enables the directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell. MF
GO:0015234 thiamin transporter activity Enables the directed movement of thiamin into, out of, within or between cells. Thiamin is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. MF
GO:0005938 cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. CC
GO:0005935 bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. CC
GO:0005934 bud tip The end of a bud distal to the site of attachment to the mother cell. CC
GO:0005937 mating projection The projection formed by unicellular fungi in response to mating pheromone. CC
GO:0005931 nexin complex A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules. CC
GO:0005930 axoneme The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements. CC
GO:0005933 bud A daughter cell of an organism that reproduces by budding; formed by pinching off part of the parent cell. CC
GO:0005932 basal body A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth. CC
GO:0015231 5-formyltetrahydrofolate transporter activity Enables the directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells. MF
GO:0015230 FAD transporter activity Enables the directed movement of flavin-adenine dinucleotide (FAD) into, out of, within or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. MF
GO:0048900 anterior lateral line neuromast primordium migration The migration of a cluster of relatively undifferentiated cells along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. BP
GO:0007519 striated muscle development The developmental sequence of events leading to the formation of adult muscle that occurs in the animal and in cultured cells. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. BP
GO:0001586 5-HT1 receptor activity NA MF
GO:0001587 5-HT2 receptor activity NA MF
GO:0042378 quinone cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of quinone cofactors. BP
GO:0042379 chemokine receptor binding Interacting selectively with any chemokine receptor. MF
GO:0042372 phylloquinone biosynthetic process The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. BP
GO:0042373 vitamin K metabolic process The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. BP
GO:0042370 thiamin diphosphate dephosphorylation The removal of one or more phosphoric groups from thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. BP
GO:0042371 vitamin K biosynthetic process The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. BP
GO:0042376 phylloquinone catabolic process The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. BP
GO:0042377 vitamin K catabolic process The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. BP
GO:0042374 phylloquinone metabolic process The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1. BP
GO:0042375 quinone cofactor metabolic process The chemical reactions and pathways involving quinone cofactors. BP
GO:0003692 left-handed Z-DNA binding Interacting selectively with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags. MF
GO:0003693 P-element binding Interacting selectively with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis. MF
GO:0003690 double-stranded DNA binding Interacting selectively with double-stranded DNA. MF
GO:0003691 double-stranded telomeric DNA binding Interacting selectively with double-stranded telomere-associated DNA. MF
GO:0003696 satellite DNA binding Interacting selectively with satellite DNA, DNA containing highly repetitive sequences which makes up a large proportion of the eukaryotic genome. MF
GO:0003697 single-stranded DNA binding Interacting selectively with single-stranded DNA. MF
GO:0003695 random coil DNA binding Interacting selectively with DNA in a random coil configuration. MF
GO:0000352 trans assembly of SL containing precatalytic spliceosome Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA. BP
GO:0000353 formation of quadruple SL/U4/U5/U6 snRNP Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA. BP
GO:0000350 generation of catalytic spliceosome for second transesterification step Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. BP
GO:0000351 assembly of spliceosomal tri-snRNP U4/U6.U5 The formation of a tri-snRNP complex containing the U4, U6, and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP to form the tri-snRNP that is ready to reassemble into another U2-type spliceosome complex. BP
GO:0000356 U2-type catalytic spliceosome formation for first transesterification step Formation of a catalytic U2-type spliceosome complex containing the pre-mRNA ready to perform the first splicing reaction. BP
GO:0000357 U12-type catalytic spliceosome formation for first transesterification step Formation of a catalytic U12-type spliceosome complex containing the pre-mRNA ready to perform the first splicing reaction. BP
GO:0000354 cis assembly of pre-catalytic spliceosome Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. BP
GO:0000355 assembly of spliceosomal tri-snRNP U4atac/U6atac.U5 The formation of a tri-snRNP complex containing the U4atac, U6atac, and U5 snRNAs and associated proteins. This includes reannealing of U4atac and U6atac snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP as well as the subsequent association of the U5 snRNP with the U4atac/U6atac snRNP to form a tri-snRNP that is ready to reassemble into another U12-type spliceosome complex. BP
GO:0000358 formation of catalytic U2-type spliceosome for second transesterification step Conformational rearrangement of the U2-type spliceosomal complex containing the RNA products of the first step of splicing to form the catalytic site for the second step of splicing. BP
GO:0000359 formation of catalytic U12-type spliceosome for second transesterification step Conformational rearrangement of the U12-type spliceosomal complex containing the RNA products of the 1st step of splicing to form the catalytic site for the second step of splicing. BP
GO:0048613 embryonic ectodermal gut morphogenesis The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048612 post-embryonic ectodermal gut development The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. BP
GO:0048611 embryonic ectodermal gut development The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. BP
GO:0005200 structural constituent of cytoskeleton The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. MF
GO:0048617 embryonic foregut morphogenesis The process by which the anatomical structures of the foregut are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0048616 post-embryonic anterior midgut (ectodermal) morphogenesis The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0048615 embryonic anterior midgut (ectodermal) morphogenesis The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0048614 post-embryonic ectodermal gut morphogenesis The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048619 embryonic hindgut morphogenesis The process by which the anatomical structures of the hindgut are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0048618 post-embryonic foregut morphogenesis The process by which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0001588 dopamine D1 receptor-like receptor activity A G-protein coupled receptor that binds the neurotransmitter dopamine and activates adenylate cyclase via coupling to Gs. MF
GO:0007514 garland cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a garland cells, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis. BP
GO:0007517 muscle development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. BP
GO:0007516 hemocyte development (sensu Arthropoda) The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body). As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0015233 pantothenate transporter activity Enables the directed movement of pantothenate into, out of, within or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. MF
GO:0015232 heme transporter activity Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. MF
GO:0007513 pericardial cell differentiation The process whereby a relatively unspecialized mesodermal cell acquires the specialized features of a pericardial cell. In insects, pericardial cells are loosely arranged non-myogenic cells that flank the cardioblasts and probably act in the filtration of hemolymph. BP
GO:0007512 adult heart development The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. BP
GO:0001580 detection of chemical stimulus during sensory perception of bitter taste The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. BP
GO:0001581 detection of chemical stimulus during sensory perception of sour taste The series of events required for a sour taste stimulus to be received and converted to a molecular signal. BP
GO:0001582 detection of chemical stimulus during sensory perception of sweet taste The series of events required for a sweet taste stimulus to be received and converted to a molecular signal. BP
GO:0001583 detection of chemical stimulus during sensory perception of salty taste The series of events required for a salty taste stimulus to be received and converted to a molecular signal. BP
GO:0001584 rhodopsin-like receptor activity A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor. MF
GO:0007518 myoblast cell fate determination Process by which a cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0015239 multidrug transporter activity Enables the directed movement of drugs into, out of, within or between cells. MF
GO:0015238 drug transporter activity Enables the directed movement of a drug into, out of, within or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. MF
GO:0019725 cell homeostasis The processes involved in the maintenance of an internal equilibrium at the level of the cell. BP
GO:0019724 B cell mediated immunity Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. BP
GO:0019727 mevaldate reductase (NAD+) activity Catalysis of the reaction: (R)-mevalonate + NAD+ = mevaldate + NADH + H+. MF
GO:0019726 mevaldate reductase (NADPH) activity Catalysis of the reaction: (R)-mevalonate + NADP+ = mevaldate + NADPH + H+. MF
GO:0019720 Mo-molybdopterin cofactor metabolic process The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. BP
GO:0019722 calcium-mediated signaling A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response. BP
GO:0019729 peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. BP
GO:0019728 peptidyl-allysine oxidation to 2-aminoadipic acid The oxidation of allysine to 2-aminoadipic acid. BP
GO:0042483 negative regulation of odontogenesis Any process that stops, prevents or reduces the frequency, rate or extent of the formation and development of a tooth or teeth. BP
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). MF
GO:0016767 geranylgeranyl-diphosphate geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate. MF
GO:0016760 cellulose synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1). MF
GO:0016761 cellulose synthase (GDP-forming) activity Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1). MF
GO:0016762 xyloglucan:xyloglucosyl transferase activity Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. MF
GO:0016763 transferase activity, transferring pentosyl groups Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). MF
GO:0016768 spermine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. MF
GO:0016769 transferase activity, transferring nitrogenous groups Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). MF
GO:0048824 pigment cell precursor differentiation The process whereby a relatively unspecialized cell acquires specialized features of a pigment cell precursor. BP
GO:0002097 tRNA wobble base modification The process whereby the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified. BP
GO:0002096 polkadots A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals. CC
GO:0047403 lacto-N-biosidase activity Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc. MF
GO:0035116 embryonic hindlimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. Morphogenesis pertains to the creation of form. The hindlimbs are the posterior limbs of an animal. BP
GO:0035117 embryonic arm morphogenesis The process, occurring in the embryo, by which the anatomical structures of the arm are generated and organized. Morphogenesis pertains to the creation of form. In humans, the arms are the two upper limbs of the body from the shoulder to the hand. BP
GO:0035110 leg morphogenesis The process by which the anatomical structures of leg are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands. BP
GO:0035111 leg joint morphogenesis The process by which the anatomical structures of leg joint are generated and organized. Morphogenesis pertains to the creation of form. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. For example the knee, which separates the leg tibia and femur. BP
GO:0035112 genitalia morphogenesis The process by which the anatomical structures of genitalia are generated and organized. Morphogenesis pertains to the creation of form. The genitalia are the organs of reproduction or generation, external and internal. BP
GO:0035113 embryonic appendage morphogenesis The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch. BP
GO:0012511 lipid storage body (sensu Viridiplantae) A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. A droplet of triacylglycerol surrounded by a monolayer of phospholipids, interacting with the triacylglycerols and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0012510 trans-Golgi network transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. CC
GO:0031020 plastid mRNA editing complex An mRNA editing complex found in a plastid. CC
GO:0031021 interphase microtubule organizing center A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus. CC
GO:0031022 nuclear migration along microfilament The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. BP
GO:0031023 microtubule organizing center organization and biogenesis The assembly and arrangement of a microtubule organizing center, a structure from which microtubules grow. BP
GO:0031024 interphase microtubule organizing center formation The assembly of gamma-tubulin and other proteins into an interphase microtubule organizing center. BP
GO:0031025 equatorial microtubule organizing center disassembly The process by which the equatorial microtubule organizing center is disassembled at the end of mitosis. BP
GO:0031026 glutamate synthase complex A complex that possesses glutamate synthase activity. CC
GO:0031027 glutamate synthase complex (NADH) A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. CC
GO:0031028 septation initiation signaling The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the begining of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis. BP
GO:0031029 regulation of septation initiation signaling Any process that modulates the frequency, rate or extent of septation initiation signaling. BP
GO:0017148 negative regulation of protein biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. BP
GO:0017147 Wnt-protein binding Interacting selectively with Wnt-protein, a secreted growth factor involved in signaling. MF
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the centre of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. CC
GO:0017145 stem cell division The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. BP
GO:0017144 drug metabolic process The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. BP
GO:0017143 insecticide metabolic process The chemical reactions and pathways involving insecticides, chemicals used to kill insects. BP
GO:0017140 lipoic acid synthase activity Catalysis of the reaction: octanoic acid + 2 S = lipoic acid + 2 H. MF
GO:0009238 enterobactin metabolic process The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. BP
GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. BP
GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. BP
GO:0009237 siderophore metabolic process The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. BP
GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. BP
GO:0009235 cobalamin metabolic process The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. BP
GO:0009232 riboflavin catabolic process The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). BP
GO:0009233 menaquinone metabolic process The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. BP
GO:0003858 3-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+. MF
GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). BP
GO:0009581 detection of external stimulus The series of events in which an external stimulus is received by a cell and converted into a molecular signal. BP
GO:0009582 detection of abiotic stimulus The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. BP
GO:0009583 detection of light stimulus The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. BP
GO:0009584 detection of visible light The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. BP
GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. BP
GO:0009586 rhodopsin mediated phototransduction The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events then required to return the rhodopsin containing cell to the unexcited state. BP
GO:0009588 UV-A, blue light phototransduction The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of approximately 400-500 nm. BP
GO:0009589 detection of UV The series of events in which an ultraviolet radiation (UV light) stimulus is received by a cell and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. BP
GO:0008188 neuropeptide receptor activity Combining with a neuropeptide to initiate a change in cell activity. MF
GO:0008187 poly-pyrimidine tract binding Interacting selectively with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. MF
GO:0008186 RNA-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction. MF
GO:0008184 glycogen phosphorylase activity Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. MF
GO:0008180 signalosome complex A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. CC
GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). CC
GO:0045255 hydrogen-translocating F-type ATPase complex NA CC
GO:0045256 hydrogen-translocating F-type ATPase complex (sensu Bacteria) A multisubunit hydrogen-translocating F-type ATPase. F-type ATPases have 2 components, CF(1), the catalytic core, and CF(0), the membrane proton channel. CF(1) has five subunits, alpha(3), beta(3), gamma(1), delta(1), and epsilon(1). CF(0) has three main subunits, a, b and c. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045257 succinate dehydrogenase complex (ubiquinone) The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. CC
GO:0045250 pyruvate dehydrogenase complex (sensu Bacteria) Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045251 electron transfer flavoprotein complex A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system. CC
GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). CC
GO:0045253 pyruvate dehydrogenase (lipoamide) phosphatase complex A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. CC
GO:0045258 succinate dehydrogenase complex (ubiquinone) (sensu Bacteria) The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045259 proton-transporting ATP synthase complex The complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation; it catalyzes the hydrolysis of ATP to ADP and orthophosphate. CC
GO:0032700 negative regulation of interleukin-17 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-17 production. BP
GO:0032701 negative regulation of interleukin-18 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production. BP
GO:0032702 negative regulation of interleukin-19 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production. BP
GO:0032703 negative regulation of interleukin-2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. BP
GO:0032704 negative regulation of interleukin-20 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production. BP
GO:0032705 negative regulation of interleukin-21 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production. BP
GO:0032706 negative regulation of interleukin-22 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production. BP
GO:0032707 negative regulation of interleukin-23 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production. BP
GO:0032708 negative regulation of interleukin-24 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production. BP
GO:0032709 negative regulation of interleukin-25 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production. BP
GO:0047392 CMP-N-acylneuraminate phosphodiesterase activity Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP. MF
GO:0015178 S-methylmethionine permease activity NA MF
GO:0015179 L-amino acid transporter activity Enables the directed movement of L-amino acids into, out of, within or between cells. MF
GO:0015174 basic amino acid transporter activity Enables the directed movement of basic amino acids, amino acids with a pH above 7, into, out of, within or between cells. MF
GO:0015175 neutral amino acid transporter activity Enables the directed movement of neutral amino acids, amino acids with no net charge, into, out of, within or between cells. MF
GO:0015177 S-adenosylmethionine permease activity NA MF
GO:0015170 propanediol transporter activity Enables the directed movement of propanediol into, out of, within or between cells. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. MF
GO:0015171 amino acid transporter activity Enables the directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells. MF
GO:0015172 acidic amino acid transporter activity Enables the directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells. MF
GO:0015173 aromatic amino acid transporter activity Enables the directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of, within or between cells. MF
GO:0042147 retrograde transport, endosome to Golgi The directed movement of membrane bound vesicles from recycling endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. BP
GO:0047090 benzoyl-CoA 3-monooxygenase activity Catalysis of the reaction: benzoyl-CoA + O2 + NADPH = H2O + NADP+ + 3-hydroxybenzoyl-CoA. MF
GO:0047091 L-lysine 6-monooxygenase (NADPH) activity Catalysis of the reaction: O2 + NADPH + H+ + L-lysine = H2O + NADP+ + N6-hydroxy-L-lysine. MF
GO:0047092 27-hydroxycholesterol 7-alpha-monooxygenase activity Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol. MF
GO:0047093 4-hydroxyquinoline 3-monooxygenase activity Catalysis of the reaction: O2 + NADH + quinolin-4-ol = H2O + NAD+ + quinolin-3,4-diol. MF
GO:0047094 3-hydroxyphenylacetate 6-hydroxylase activity Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate. MF
GO:0047095 2-hydroxycyclohexanone 2-monooxygenase activity Catalysis of the reaction: O2 + NADPH + 2-hydroxycyclohexan-1-one = H2O + NADP+ + 6-hydroxyhexan-6-olide. MF
GO:0047096 androst-4-ene-3,17-dione monooxygenase activity Catalysis of the reaction: O2 + donor-H2 + androst-4-ene-3,17-dione = H2O + acceptor + 3-oxo-13,17-secoandrost-4-eno-17,13-alpha-lactone. MF
GO:0047097 phylloquinone monooxygenase (2,3-epoxidizing) activity Catalysis of the reaction: O2 + donor-H2 + vitamin K1 = H2O + acceptor + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone. MF
GO:0047098 Latia-luciferin monooxygenase (demethylating) activity Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin. MF
GO:0043128 positive regulation of 1-phosphatidylinositol 4-kinase activity Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase. BP
GO:0048655 tapetal layer morphogenesis The process by which the anatomical structures of the tapetal layer are generated and organized. Morphogenesis pertains to the creation of form. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. BP
GO:0002637 regulation of immunoglobulin production Any process that modulates the frequency, rate, or extent of immunoglobulin production. BP
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB cascade Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. BP
GO:0002635 negative regulation of germinal center formation Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation. BP
GO:0002634 regulation of germinal center formation Any process that modulates the frequency, rate, or extent of germinal center formation. BP
GO:0002633 positive regulation of granuloma formation Any process that activates or increases the frequency, rate, or extent of granuloma formation. BP
GO:0002632 negative regulation of granuloma formation Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation. BP
GO:0002631 regulation of granuloma formation Any process that modulates the frequency, rate, or extent of granuloma formation. BP
GO:0043125 ErbB-3 class receptor binding Interacting selectively with the protein-tyrosine kinase receptor ErbB-3/HER3. MF
GO:0002639 positive regulation of immunoglobulin production Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. BP
GO:0002638 negative regulation of immunoglobulin production Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. BP
GO:0030038 contractile actin filament bundle formation Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. BP
GO:0035048 splicing factor protein import into nucleus The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0035049 juvenile hormone acid methyltransferase activity Catalysis of the transfer of a methyl group to juvenile hormone acid. MF
GO:0035046 pronuclear migration The directed movement of the male and female pronuclei towards each other prior to their fusion. BP
GO:0035047 centrosomal and pronuclear rotation The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion. BP
GO:0035044 sperm aster formation Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei. BP
GO:0030033 microvillus biogenesis Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. BP
GO:0030034 microvillar actin bundle formation Assembly of the parallel bundle of actin filaments at the core of a microvillus. BP
GO:0030035 microspike biogenesis Formation of a microspike, a thin, stiff projection extended from the surface of a migrating cell. BP
GO:0035040 sperm nuclear envelope removal Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus. BP
GO:0030037 actin filament reorganization during cell cycle The cell cycle process whereby rearrangement of the spatial distribution of actin filaments and associated proteins occurs. BP
GO:0043348 neuroblast fate determination (sensu Vertebrata) Process by which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043349 neuroblast proliferation (sensu Nematoda and Protostomia) The rapid expansion of a neuroblast population by cell division. Neuroblasts are embryonic cells which develop into nerve cells or neurons. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043344 maintenance of neuroblast polarity (sensu Vertebrata) The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043345 neuroblast division (sensu Vertebrata) The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043346 neuroblast division (sensu Nematoda and Protostomia) The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043347 neuroblast fate determination (sensu Nematoda and Protostomia) Process by which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043340 establishment of neuroblast polarity (sensu Nematoda and Protostomia) The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043341 maintenance of neuroblast polarity (sensu Nematoda and Protostomia) The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043342 establishment and/or maintenance of neuroblast polarity (sensu Vertebrata) The specification, formation and maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043343 establishment of neuroblast polarity (sensu Vertebrata) The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0048451 petal formation The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0048450 floral organ structural organization The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048453 sepal formation The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0048452 petal structural organization The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048455 stamen formation The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0048454 sepal structural organization The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048457 floral whorl morphogenesis The process by which the anatomical structures of the floral whorl are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048456 stamen structural organization The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048459 floral whorl structural organization The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048458 floral whorl formation The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0048654 anther morphogenesis The process by which the anatomical structures of the anther are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0009918 sterol delta7 reductase activity Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol. MF
GO:0009913 epidermal cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. BP
GO:0009912 auditory receptor cell fate commitment The process by which the cellular identity of auditory hair cells is acquired and determined. BP
GO:0009911 positive regulation of flower development Any process that activates or increases the frequency, rate or extent of flower development. BP
GO:0009910 negative regulation of flower development Any process that stops, prevents or reduces the frequency, rate or extent of flower development. BP
GO:0009917 sterol 5-alpha reductase activity Catalysis of the removal of a C-5 double bond in the B ring of a sterol. MF
GO:0009916 alternative oxidase activity Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product. MF
GO:0009915 phloem loading The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink. BP
GO:0009914 hormone transport The directed movement of hormones into, out of, within or between cells. BP
GO:0031349 positive regulation of defense response Any process that activates or increases the frequency, rate or extent of a defense response. BP
GO:0031348 negative regulation of defense response Any process that stops, prevents or reduces the frequency, rate or extent of a defense response. BP
GO:0042769 DNA damage response, detection of DNA damage The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. BP
GO:0042768 ecdysteroid 2-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 2. MF
GO:0031341 regulation of cell killing Any process that modulates the frequency, rate or extent of cell killing, the process by which a cell brings about the death of another cell, either in the same or a different organism. BP
GO:0031340 positive regulation of vesicle fusion Any process that activates or increases the frequency, rate or extent of vesicle fusion. BP
GO:0031343 positive regulation of cell killing Any process that activates or increases the frequency, rate or extent of cell killing. BP
GO:0031342 negative regulation of cell killing Any process that stops, prevents or reduces the frequency, rate or extent of cell killing. BP
GO:0031345 negative regulation of cell projection organization and biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of the processes involved in the assembly and arrangement of cell projections. BP
GO:0031344 regulation of cell projection organization and biogenesis Any process that modulates the frequency, rate or extent of the process involved in the assembly and arrangement of cell projections. BP
GO:0031347 regulation of defense response Any process that modulates the frequency, rate or extent of a defense response. BP
GO:0031346 positive regulation of cell projection organization and biogenesis Any process that activates or increases the frequency, rate or extent of the process involved in the assembly and arrangement of cell projections. BP
GO:0008852 exodeoxyribonuclease I activity Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. MF
GO:0050461 L-mimosine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate. MF
GO:0050460 hydroxylamine reductase (NADH) activity Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+. MF
GO:0050463 nitrate reductase [NAD(P)H] activity Catalysis of the reaction: NO2- (nitrite) + NAD(P)+ + H2O = NO3- (nitrate) + NAD(P)H + H+. MF
GO:0050462 N-acetylneuraminate synthase activity Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate . MF
GO:0050465 nitroquinoline-N-oxide reductase activity Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+. MF
GO:0050464 nitrate reductase (NADPH) activity Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+. MF
GO:0050467 pentalenene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = pentalenene + diphosphate. MF
GO:0050469 sabinene-hydrate synthase activity Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + sabinene hydrate. MF
GO:0050468 reticuline oxidase activity Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2. MF
GO:0048189 Lid2 complex A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p. CC
GO:0048188 COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p. CC
GO:0048183 activin AB complex A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B. CC
GO:0048180 activin complex A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit. CC
GO:0048187 inhibin beta-B binding Interacting selectively with inhibin beta-B. MF
GO:0048186 inhibin beta-A binding Interacting selectively with inhibin beta-A. MF
GO:0048185 activin binding Interacting selectively with activin. MF
GO:0048184 follistatin binding Interacting selectively with follistatin. MF
GO:0032069 regulation of nuclease activity Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. BP
GO:0032068 Type IV site-specific deoxyribonuclease complex A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation. CC
GO:0032061 negative regulation of translation in response to osmotic stress Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. BP
GO:0032060 bleb formation The assembly of a bleb, a cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions. BP
GO:0032063 negative regulation of translation initiation in response to osmotic stress Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. BP
GO:0032062 positive regulation of translation in response to osmotic stress Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. BP
GO:0032065 cortical protein anchoring A process which results in the anchoring of a protein or protein complex to the cell cortex. BP
GO:0032064 positive regulation of translation initiation in response to osmotic stress Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. BP
GO:0032067 Type IV site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated). MF
GO:0032066 nucleolus to nucleoplasm transport The directed movement of substances from the nucleolus to the nucleoplasm. BP
GO:0019259 2-aminobenzoate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2. BP
GO:0019258 4-nitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene. BP
GO:0019255 glucose 1-phosphate metabolic process The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1. BP
GO:0019254 carnitine metabolic process, CoA-linked The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA. BP
GO:0019257 4-nitrotoluene metabolic process The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor. BP
GO:0019256 acrylonitrile catabolic process The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. BP
GO:0019251 anaerobic cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen. BP
GO:0019250 aerobic cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen. BP
GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. BP
GO:0019252 starch biosynthetic process The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants. BP
GO:0019879 peptidyl-thyronine biosynthetic process from peptidyl-tyrosine The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine. BP
GO:0019878 lysine biosynthetic process via aminoadipic acid The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. BP
GO:0019871 sodium channel inhibitor activity NA MF
GO:0019870 potassium channel inhibitor activity NA MF
GO:0019872 streptomycin biosynthetic process The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. BP
GO:0019875 6-aminohexanoate-dimer hydrolase activity Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate. MF
GO:0019874 6-aminohexanoate-cyclic-dimer hydrolase activity Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate. MF
GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. BP
GO:0019876 nylon catabolic process The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. BP
GO:0060035 notochord cell development The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. BP
GO:0060034 notochord cell differentiation The process whereby relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate. BP
GO:0060036 notochord cell vacuolation The assembly and arrangement of a vacuole within a cell of the notochord. BP
GO:0060031 mediolateral intercalation The interdigitation of cells along the mediolateral axis during gastrulation. BP
GO:0060030 dorsal convergence The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement. BP
GO:0060033 anatomical structure regression The developmental process by which an anatomical stucture is destroyed as a part of its normal progression. BP
GO:0060032 notochord regression The developmental process by which the stucture of the notochord is destroyed in an embryo. BP
GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. BP
GO:0006478 peptidyl-tyrosine sulfation The posttranslational sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine. BP
GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. BP
GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. BP
GO:0006473 protein amino acid acetylation The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. BP
GO:0006475 internal protein amino acid acetylation NA BP
GO:0006474 N-terminal protein amino acid acetylation The acetylation of the N-terminal amino acid of proteins. BP
GO:0006477 protein amino acid sulfation The addition of a sulfate group as an ester to a protein amino acid. BP
GO:0006476 protein amino acid deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. BP
GO:0048845 venous blood vessel morphogenesis The process by which the anatomical structures of venous blood vessels are generated and organized. Morphogenesis pertains to the creation of form. Veins are blood vessels that transport blood from the body and its organs to the heart. BP
GO:0000142 bud neck contractile ring A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. CC
GO:0000140 acylglycerone-phosphate reductase activity Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+. MF
GO:0000147 actin cortical patch assembly Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. BP
GO:0000146 microfilament motor activity Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). MF
GO:0000145 exocyst Protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. CC
GO:0000144 bud neck septin ring A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. CC
GO:0000149 SNARE binding Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. MF
GO:0000148 1,3-beta-glucan synthase complex The complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. CC
GO:0018393 internal peptidyl-lysine acetylation NA BP
GO:0018392 glycoprotein 3-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosaminyl}asparagine. MF
GO:0018391 C-terminal peptidyl-glutamic acid tyrosinylation NA BP
GO:0018390 peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester. BP
GO:0018397 peptidyl-phenylalanine bromination to L-2'-bromophenylalanine The posttranslational bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine. BP
GO:0018396 peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine. BP
GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine. BP
GO:0018394 peptidyl-lysine acetylation The acetylation of peptidyl-lysine. BP
GO:0018399 peptidyl-phenylalanine bromination to L-4'-bromophenylalanine The posttranslational bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine. BP
GO:0018398 peptidyl-phenylalanine bromination to L-3'-bromophenylalanine The posttranslational bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine. BP
GO:0018645 alkene monooxygenase activity Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O. MF
GO:0018644 toluene 2-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene. MF
GO:0018647 phenanthrene 1,2-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide. MF
GO:0018646 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate. MF
GO:0018641 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. MF
GO:0018640 dibenzothiophene monooxygenase activity Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O. MF
GO:0018643 carbon disulfide oxygenase activity Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide. MF
GO:0018642 chlorophenol 4-monooxygenase activity Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol. MF
GO:0018649 tetrahydrofuran hydroxylase activity Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran. MF
GO:0018648 methanesulfonic acid monooxygenase activity Catalysis of the reaction: methanesulfonic acid + O2 + NADH = OH- + NAD+ + sulfurous acid + formaldehyde. MF
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist. BP
GO:0051089 constitutive protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands. BP
GO:0051084 posttranslational protein folding The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. BP
GO:0051085 chaperone cofactor-dependent protein folding The process of assisting in the correct noncovalent assembly of posttranslational proteins and is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. BP
GO:0051086 chaperone cofactor-independent protein folding The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release. BP
GO:0051087 chaperone binding Interacting selectively with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. MF
GO:0051080 meiosis II nuclear envelope disassembly The controlled breakdown of the nuclear envelope during the second division of meiosis. BP
GO:0051081 nuclear envelope disassembly The controlled breakdown of the nuclear envelope in the context of a normal process. BP
GO:0051082 unfolded protein binding Interacting selectively with an unfolded protein. MF
GO:0051083 cotranslational protein folding The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. BP
GO:0015373 monovalent anion:sodium symporter activity Catalysis of the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in). MF
GO:0015370 solute:sodium symporter activity Catalysis of the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). MF
GO:0015371 galactose:sodium symporter activity Catalysis of the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in). MF
GO:0015377 cation:chloride symporter activity Catalysis of the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). MF
GO:0015374 neutral, cationic amino acid:sodium:chloride symporter activity Catalysis of the reaction: neutral/cationic amino acid(out) + Na+(out) + Cl-(out) = neutral/cationic amino acid(in) + Na+(in) + Cl-(in). MF
GO:0015375 glycine:sodium symporter activity Catalysis of the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). MF
GO:0015378 sodium:chloride symporter activity Catalysis of the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in). MF
GO:0015379 potassium:chloride symporter activity Catalysis of the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). MF
GO:0009230 thiamin catabolic process The chemical reactions and pathways resulting in the breakdown of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. BP
GO:0051556 leucoanthocyanidin metabolic process The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids. BP
GO:0051557 leucoanthocyanidin biosynthetic process The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids. BP
GO:0051554 flavonol metabolic process The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. BP
GO:0051555 flavonol biosynthetic process The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. BP
GO:0051552 flavone metabolic process The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). BP
GO:0051553 flavone biosynthetic process The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). BP
GO:0051550 aurone metabolic process The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides. BP
GO:0051551 aurone biosynthetic process The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments. BP
GO:0051558 phlobaphene metabolic process The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. BP
GO:0051559 phlobaphene biosynthetic process The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. BP
GO:0001799 regulation of type IIb hypersensitivity Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response. BP
GO:0001798 positive regulation of type IIa hypersensitivity Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response. BP
GO:0001791 IgM binding Interacting selectively with an immunoglobulin of the IgM isotype. MF
GO:0001790 polymeric immunoglobulin binding Interacting selectively with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes. MF
GO:0001793 IgM receptor activity Combining with an immunoglobulin of the IgM isotype via the Fc region to initiate a change in cell activity. MF
GO:0001792 polymeric immunoglobulin receptor activity Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity. MF
GO:0001795 type IIb hypersensitivity An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors. BP
GO:0001794 type IIa hypersensitivity An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell. BP
GO:0001797 negative regulation of type IIa hypersensitivity Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response. BP
GO:0001796 regulation of type IIa hypersensitivity Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response. BP
GO:0016135 saponin biosynthetic process The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. BP
GO:0016134 saponin metabolic process The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. BP
GO:0019118 phenanthrene-epoxide hydrolase activity NA MF
GO:0019119 phenanthrene-9,10-epoxide hydrolase activity NA MF
GO:0016131 brassinosteroid metabolic process The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. BP
GO:0016130 phytosteroid catabolic process The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids of higher plants differing from animal steroids C1 or C2 residues at C24 and/or a double bond at C22. BP
GO:0016133 brassinosteroid catabolic process The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. BP
GO:0016132 brassinosteroid biosynthetic process The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. BP
GO:0019112 phenanthrol glycosyltransferase activity Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O. MF
GO:0019113 limonene monooxygenase activity NA MF
GO:0019110 oxidoreductase activity, acting on iron-sulfur proteins as donors, hydrogen ions as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces hydrogen ions. MF
GO:0019111 phenanthrol sulfotransferase activity Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate. MF
GO:0019116 hydroxy-nicotine oxidase activity Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2. MF
GO:0016138 glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. BP
GO:0019114 catechol dioxygenase activity NA MF
GO:0019115 benzaldehyde dehydrogenase activity Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+. MF
GO:0046039 GTP metabolic process The chemical reactions and pathways involving GTP, guanosine triphosphate. BP
GO:0046038 GMP catabolic process The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate. BP
GO:0046037 GMP metabolic process The chemical reactions and pathways involving GMP, guanosine monophosphate. BP
GO:0046036 CTP metabolic process The chemical reactions and pathways involving CTP, cytidine triphosphate. BP
GO:0030238 male sex determination The specification of male sex of an individual organism. BP
GO:0030239 myofibril assembly Formation of myofibrils, the repeating units of striated muscle. BP
GO:0030236 anti-inflammatory response A process that attenuates the inflammatory response. BP
GO:0030237 female sex determination The specification of female sex of an individual organism. BP
GO:0030234 enzyme regulator activity Modulates the activity of an enzyme. MF
GO:0030235 nitric-oxide synthase regulator activity Modulates the activity of nitric oxide synthase. MF
GO:0030232 insulin control element activator complex Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription. CC
GO:0030233 deoxynucleotide transporter activity Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. MF
GO:0048846 axon extension involved in axon guidance The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. BP
GO:0048847 adenohypophysis formation The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. BP
GO:0002002 regulation of angiotensin levels in blood The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin. BP
GO:0030580 quinone cofactor methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1). MF
GO:0030581 intracellular protein transport in host The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0030582 fruiting body development Formation of a multicellular structure that contains spores. BP
GO:0005055 laminin receptor activity Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. MF
GO:0030584 fruiting body development (sensu Fungi) Formation of a spore-bearing structure. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0030585 phosphoenolpyruvate carboxykinase (diphosphate) activity Catalysis of the reaction: diphosphate + oxaloacetate = phosphate + phosphoenolpyruvate + CO2. MF
GO:0030586 [methionine synthase] reductase activity Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. MF
GO:0030587 fruiting body development (sensu Dictyosteliida) The process by which a cellular slime mold forms the terminally differentiated organism that consists of a long stalk on top of which sits the sorus that contains the spores. As in, but not restricted to, the taxon Dictyosteliida (Dictyosteliida, ncbi_taxonomy_id:33083). BP
GO:0030588 pseudocleavage Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis. BP
GO:0002004 secretion of vasopressin during fast regulation of blood pressure The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland during fast regulation of blood pressure. BP
GO:0048843 negative regulation of axon extension involved in axon guidance Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in axon guidance. BP
GO:0048840 otolith development The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure. BP
GO:0002007 detection of hypoxic conditions in blood by chemoreceptors The process by which information about the levels of oxygen, carbon dioxide and hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. BP
GO:0002322 B cell proliferation during immune response The rapid expansion of a B cell population by cell division following B cell activation during an immune response. BP
GO:0031189 siderophore biosynthetic process from catechol, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of a catechol-derived siderophore. BP
GO:0031188 pyochelin biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within the siderophore pyochelin. BP
GO:0031187 pyochelin biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore pyochelin. BP
GO:0031186 ferricrocin biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within the siderophore ferricrocin. BP
GO:0031185 ferricrocin biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore ferricrocin. BP
GO:0031184 chrysobactin biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within the siderophore chrysobactin. BP
GO:0031183 chrysobactin biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore chrysobactin. BP
GO:0031182 achromobactin biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within the siderophore achromobactin. BP
GO:0031181 achromobactin biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore achromobactin. BP
GO:0031180 siderophore biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within a siderophore. Includes the formation of heterocycles such as thiazoline rings and oxazoline rings. BP
GO:0002202 somatic diversification of variable lymphocyte receptors of jawless fish The somatic process by means of which sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish is generated. BP
GO:0002817 negative regulation of biosynthetic process of antibacterial peptides active against anti-Gram-positive bacteria Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-positive bacteria. BP
GO:0002816 regulation of biosynthetic process of antibacterial peptides active against anti-Gram-positive bacteria Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-positive bacteria. BP
GO:0002815 biosynthetic process of antibacterial peptides active against anti-Gram-positive bacteria The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria. BP
GO:0002814 negative regulation of biosynthetic process of antibacterial peptides active against anti-Gram-negative bacteria Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-negative bacteria. BP
GO:0002813 regulation of biosynthetic process of antibacterial peptides active against anti-Gram-negative bacteria Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-negative bacteria. BP
GO:0002812 biosynthetic process of antibacterial peptides active against anti-Gram-negative bacteria The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria. BP
GO:0002811 negative regulation of antifungal peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis. BP
GO:0002810 regulation of antifungal peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis. BP
GO:0002819 regulation of adaptive immune response Any process that modulates the frequency, rate, or extent of an adaptive immune response. BP
GO:0002818 intracellular defense response A physiological defense response which occurs intracellularly. BP
GO:0009791 post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. BP
GO:0009790 embryonic development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. BP
GO:0009793 embryonic development (sensu Magnoliophyta) The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009792 embryonic development (sensu Metazoa) The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism specific and may be somewhat arbitrary; for mammals it is usually considered to be birth; for insects the hatching of the first instar larva from the eggshell. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0009794 regulation of progression through embryonic mitotic cell cycle Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo. BP
GO:0009797 cellularization (sensu Magnoliophyta) The separation of a multi-nucleate cell into individual cells each surrounded by a plasma membrane and a complete or rudimentary cell wall. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009796 cellularization (sensu Metazoa) The separation of a multi-nucleate cell or syncytium into individual cells. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0009799 determination of symmetry The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. BP
GO:0002203 proteolysis by cytosolic proteases associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation. BP
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. MF
GO:0046935 phosphatidylinositol 3-kinase regulator activity Modulates the activity of the enzyme phosphatidylinositol 3-kinase activity. MF
GO:0046936 deoxyadenosine deaminase activity Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3. MF
GO:0046937 phytochelatin metabolic process The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. BP
GO:0046930 pore complex Any small opening in a membrane that allows the passage of gases and/or liquids. CC
GO:0046931 pore complex biogenesis The formation of a pore complex, a small opening in a membrane that allows the passage of liquids and/or gases. BP
GO:0046932 sodium-transporting ATP synthase activity, rotational mechanism Catalysis of the reaction: ADP + phosphate + Na+(out) = ATP + H2O + Na+(in), by a rotational mechanism. MF
GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism Catalysis of the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. MF
GO:0046938 phytochelatin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. BP
GO:0046939 nucleotide phosphorylation The process of introducing one or more phosphoric groups into a nucleotide to produce a phosphorylated nucleoside. BP
GO:0002200 somatic diversification of immune receptors The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. BP
GO:0008446 GDP-mannose 4,6-dehydratase activity Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O. MF
GO:0008447 L-ascorbate oxidase activity Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O. MF
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate. MF
GO:0008445 D-aspartate oxidase activity Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2. MF
GO:0008442 3-hydroxyisobutyrate dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. MF
GO:0008443 phosphofructokinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule. MF
GO:0008440 inositol trisphosphate 3-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. MF
GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. MF
GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. MF
GO:0008449 N-acetylglucosamine-6-sulfatase activity Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. MF
GO:0042109 tumor necrosis factor-beta biosynthetic process The chemical reactions and pathways resulting in the formation of the cytokine tumor necrosis factor-beta. BP
GO:0042108 positive regulation of cytokine biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. BP
GO:0042105 alpha-beta T cell receptor complex NA CC
GO:0042104 positive regulation of activated T cell proliferation Any process that activates or increases the rate or extent of activated T cell proliferation. BP
GO:0042107 cytokine metabolic process The chemical reactions and pathways involving cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. BP
GO:0042106 gamma-delta T cell receptor complex NA CC
GO:0042101 T cell receptor complex A receptor complex usually consisting of a TCR- (T cell receptor) alpha and beta chain heterodimer, two CD3-epsilon chains, a CD3-gamma chain, a CD3-delta chain and a zeta chain homodimer. The complex mediates antigen recognition, ultimately resulting in T cell activation. CC
GO:0042100 B cell proliferation The rapid expansion of a B cell population by cell division. Follows B cell activation. BP
GO:0042103 positive regulation of T cell homeostatic proliferation Any process that activates or increases the rate or extent of resting T cell proliferation. BP
GO:0042102 positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation. BP
GO:0045779 negative regulation of bone resorption Any process that stops, prevents or reduces the frequency, rate or extent of bone resorption. BP
GO:0045778 positive regulation of ossification Any process that activates or increases the frequency, rate or extent of bone formation. BP
GO:0045777 positive regulation of blood pressure Any process that increases blood pressure. BP
GO:0045776 negative regulation of blood pressure Any process that reduces blood pressure. BP
GO:0045775 positive regulation of beta 2 integrin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. BP
GO:0045774 negative regulation of beta 2 integrin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. BP
GO:0045773 positive regulation of axon extension Any process that activates or increases the frequency, rate or extent of axon extension. BP
GO:0045772 positive regulation of autophagic vacuole size Any process that increases autophagic vacuole size. BP
GO:0045771 negative regulation of autophagic vacuole size Any process that reduces autophagic vacuole size. BP
GO:0045770 positive regulation of asymmetric cell division Any process that activates or increases the frequency, rate or extent of asymmetric cell division. BP
GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH. MF
GO:0047680 aryl-acylamidase activity Catalysis of the reaction: an anilide + H2O = a carboxylate + aniline. MF
GO:0047683 aryl-aldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP. MF
GO:0047682 aryl-alcohol oxidase activity Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2. MF
GO:0047685 amine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate. MF
GO:0047684 arylamine glucosyltransferase activity Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine. MF
GO:0047687 ascorbate 2,3-dioxygenase activity Catalysis of the reaction: H2O + O2 + ascorbate = L-threonate + oxalate. MF
GO:0047686 arylsulfate sulfotransferase activity Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate. MF
GO:0047689 aspartate racemase activity Catalysis of the reaction: L-aspartate = D-aspartate. MF
GO:0047688 aspartate 4-decarboxylase activity Catalysis of the reaction: L-aspartate = L-alanine + CO2. MF
GO:0003796 lysozyme activity Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins. MF
GO:0030919 peptidyl-serine O-acetylation The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine. BP
GO:0030913 paranodal junction assembly Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. BP
GO:0030912 response to deep water A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle. BP
GO:0030911 TPR domain binding Interacting selectively with a tetratricopeptide repeat (TPR) domain of a protein, the consensu thes sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. MF
GO:0030910 olfactory placode formation The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. BP
GO:0030917 midbrain-hindbrain boundary development The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. BP
GO:0030916 otic vesicle formation The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear. BP
GO:0030915 Smc5-Smc6 complex A conserved complex that contains a heterodimer of SMC proteins (Smc5 and Smc6, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S.cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. CC
GO:0030914 STAGA complex A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. CC
GO:0050939 regulation of early stripe melanocyte differentiation Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation. BP
GO:0050938 regulation of xanthophore differentiation Any process that modulates the frequency, rate or extent of xanthophore differentiation. BP
GO:0050933 early stripe melanocyte differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development). BP
GO:0050932 regulation of pigment cell differentiation Any process that modulates the frequency, rate or extent of pigmented cell differentiation. BP
GO:0050931 pigment cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. BP
GO:0050930 induction of positive chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. BP
GO:0050937 regulation of iridophore differentiation Any process that modulates the frequency, rate or extent of iridophore differentiation. BP
GO:0050936 xanthophore differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance. BP
GO:0050935 iridophore differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance. BP
GO:0050934 late stripe melanocyte differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development). BP
GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. BP
GO:0046489 phosphoinositide biosynthetic process The chemical reactions and pathways resulting in the formation of phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. BP
GO:0046484 oxazole or thiazole metabolic process The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. BP
GO:0046485 ether lipid metabolic process The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one fatty alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. BP
GO:0046486 glycerolipid metabolic process The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. BP
GO:0046487 glyoxylate metabolic process The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. BP
GO:0046480 galactolipid galactosyltransferase activity Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol. MF
GO:0046481 UDP-galactose:MGDG galactosyltransferase activity Catalysis of the reaction: 3-beta-D-galactosyl-1,2-diacylglycerol + UDP-galactose = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + UDP. MF
GO:0046482 para-aminobenzoic acid metabolic process The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins. BP
GO:0046483 heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). BP
GO:0002772 inhibitory C-type lectin receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response. BP
GO:0002773 B cell inhibitory signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response. BP
GO:0002770 T cell inhibitory signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response. BP
GO:0002771 inhibitory killer cell immunoglobulin-like receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a lymphocyte capable of inhibiting an immune effector process contributing to an immune response. BP
GO:0002776 antimicrobial peptide secretion The regulated release of an antimicrobial peptide from a cell or group of cells. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. BP
GO:0002777 antimicrobial peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. BP
GO:0002774 Fc receptor mediated inhibitory signaling pathway A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. BP
GO:0002775 antimicrobial peptide production The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. BP
GO:0002778 antibacterial peptide production The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. BP
GO:0002779 antibacterial peptide secretion The regulated release of an antibacterial peptide from a cell or group of cells. BP
GO:0044428 nuclear part Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. CC
GO:0044429 mitochondrial part Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. CC
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. CC
GO:0044425 membrane part Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. CC
GO:0044426 cell wall part Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. CC
GO:0044427 chromosomal part Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. CC
GO:0044420 extracellular matrix part Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). CC
GO:0044421 extracellular region part Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite. CC
GO:0044422 organelle part Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane. CC
GO:0044423 virion part Any constituent part of a virion, a complete fully infectious extracellular virus particle. CC
GO:0009896 positive regulation of catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. BP
GO:0009897 external side of plasma membrane The side of the plasma membrane that is opposite to the side that faces the cytoplasm. CC
GO:0009894 regulation of catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. BP
GO:0009895 negative regulation of catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. BP
GO:0009892 negative regulation of metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. BP
GO:0009893 positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. BP
GO:0009890 negative regulation of biosynthetic process Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. BP
GO:0009891 positive regulation of biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. BP
GO:0009898 internal side of plasma membrane The side of the plasma membrane that faces the cytoplasm. CC
GO:0009899 ent-kaurene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-kaurene + diphosphate. MF
GO:0046156 siroheme metabolic process The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. BP
GO:0046157 siroheme catabolic process The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. BP
GO:0046154 rhodopsin metabolic process The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. BP
GO:0046155 rhodopsin catabolic process The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. BP
GO:0046152 ommochrome metabolic process The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. BP
GO:0046153 ommochrome catabolic process The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. BP
GO:0046150 melanin catabolic process The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. BP
GO:0046151 eye pigment catabolic process The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. BP
GO:0046158 ocellus pigment metabolic process The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. BP
GO:0046159 ocellus pigment catabolic process The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. BP
GO:0048226 Casparian strip Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants. CC
GO:0048227 plasma membrane to endosome transport Transport of a vesicle from the plasma membrane to the endosome. BP
GO:0048224 lignin network A network composed of lignin; a complex polymer of phenylpropanoid subunits, laid down in the walls of plant cells such as xylem vessels and sclerenchyma. It imparts considerable strength to the wall and also protects it against degradation by microorganisms. It is also laid down as a defence reaction against pathogenic attack, as part of the hypersensitive response of plants. CC
GO:0048225 suberin network Fatty substance, containing long chain fatty acids and fatty esters, found in the cell walls of cork cells (phellem) in higher plants. Renders the cell wall impervious to water. CC
GO:0048222 glycoprotein network A network of glycoproteins; proteins with covalently attached sugar units, either bonded via the hydroxyl group of serine or threonine (O glycosylated) or through the amino terminal of asparagine (N glycosylated). CC
GO:0048223 hemicellulose network Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan. CC
GO:0048220 cis-Golgi to rough ER vesicle-mediated transport The directed movement of substances from the Golgi apparatus to the rough endoplasmic reticulum, mediated by vesicles. BP
GO:0048221 rough ER to cis-Golgi vesicle-mediated transport The directed movement of substances from the rough endoplasmic reticulum to the cis-Golgi, mediated by small transport vesicles. BP
GO:0048228 actin cortical patch distribution The processes that establish the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells. BP
GO:0048229 gametophyte development (sensu Magnoliophyta) The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0048624 plantlet formation on parent plant The process whereby a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed. BP
GO:0042489 negative regulation of odontogenesis (sensu Vertebrata) Any process that stops, prevents or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0004329 formate-tetrahydrofolate ligase activity Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. MF
GO:0004328 formamidase activity Catalysis of the reaction: formamide + H2O = formate + NH3. MF
GO:0042480 negative regulation of eye photoreceptor cell development Any process that stops, prevents or reduces the frequency, rate or extent of eye photoreceptor development. BP
GO:0004322 ferroxidase activity Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. MF
GO:0042482 positive regulation of odontogenesis Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth. BP
GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate. MF
GO:0042484 regulation of odontogenesis (sensu Protostomia) Any process that modulates the frequency, rate or extent of the formation and development of a tooth, any hard calcareous or chitinous organ found in the mouth and used in feeding or procuring food, e.g. a mollusk or starfish tooth. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0004326 tetrahydrofolylpolyglutamate synthase activity Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). MF
GO:0042486 negative regulation of odontogenesis (sensu Protostomia) Any process that stops, prevents or reduces the frequency, rate or extent of the formation and development of a tooth, any hard calcareous or chitinous organ found in the mouth and used in feeding or procuring food, e.g. a mollusk or starfish tooth. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0004324 ferredoxin-NADP+ reductase activity Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. MF
GO:0008859 exoribonuclease II activity Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction. MF
GO:0008858 exonuclease VIII activity NA MF
GO:0006879 iron ion homeostasis The regulation of the levels, transport, and metabolism of iron ions within a cell or between a cell and its external environment. BP
GO:0006878 copper ion homeostasis The regulation of the levels, transport, and metabolism of copper ions within a cell or between a cell and its external environment. BP
GO:0003809 thrombin activity Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B. MF
GO:0003808 protein C (activated) activity Catalysis of the degradation of blood coagulation factors Va and VIIIa. MF
GO:0003807 plasma kallikrein activity Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin. MF
GO:0003806 coagulation factor XIIa activity Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa. MF
GO:0008853 exodeoxyribonuclease III activity Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. MF
GO:0003804 coagulation factor Xa activity Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa). MF
GO:0008855 exodeoxyribonuclease VII activity Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. MF
GO:0008854 exodeoxyribonuclease V activity Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. MF
GO:0008857 exonuclease IX activity NA MF
GO:0008856 exodeoxyribonuclease X activity NA MF
GO:0018409 peptide or protein amino-terminal blocking NA BP
GO:0018408 peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine The posttranslational iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine). BP
GO:0018403 protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. BP
GO:0018402 protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. BP
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline The posttranslational modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. BP
GO:0018400 peptidyl-proline hydroxylation to 3-hydroxy-L-proline The posttranslational modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase. BP
GO:0018407 peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine The posttranslational iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine). BP
GO:0018406 protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring. BP
GO:0018405 protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues. BP
GO:0018404 protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. BP
GO:0016438 tRNA-queuosine beta-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine. MF
GO:0043460 response to long exposure to lithium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus. BP
GO:0006518 peptide metabolic process The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. BP
GO:0050168 pentanamidase activity Catalysis of the reaction: pentanamide + H2O = pentanoate + NH3. MF
GO:0006831 low-affinity zinc ion transport NA BP
GO:0006519 amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids. BP
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+. MF
GO:0050160 orsellinate-depside hydrolase activity Catalysis of the reaction: orsellinate depside + H2O = 2 orsellinate. MF
GO:0050161 oxalate CoA-transferase activity Catalysis of the reaction: succinyl-CoA + oxalate = succinate + oxalyl-CoA. MF
GO:0050162 oxalate oxidase activity Catalysis of the reaction: oxalate + O2 = 2 CO2 + H2O2. MF
GO:0050163 oxaloacetate tautomerase activity Catalysis of the reaction: keto-oxaloacetate = enol-oxaloacetate. MF
GO:0050164 oxoglutarate dehydrogenase (NADP+) activity Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH. MF
GO:0006833 water transport The directed movement of water (H2O) into, out of, within or between cells. BP
GO:0050166 pantoate 4-dehydrogenase activity Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + NADH. MF
GO:0050167 pantothenoylcysteine decarboxylase activity Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2. MF
GO:0043469 regulation of D-xylose catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose. BP
GO:0043468 regulation of fucose catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose. BP
GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells. BP
GO:0006837 serotonin transport The directed movement of serotonin into, out of, within or between cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. BP
GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. BP
GO:0051417 microtubule nucleation by spindle pole body The 'de novo' formation of a microtubule, mediated by the spindle pole body. BP
GO:0051416 myotilin binding Interacting selectively with myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C. MF
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation. BP
GO:0007008 outer mitochondrial membrane organization and biogenesis The assembly and arrangement of the mitochondrial outer membrane. BP
GO:0051413 response to cortisone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues. BP
GO:0051412 response to corticosterone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. BP
GO:0051411 ALP binding Interacting selectively wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band. MF
GO:0051410 detoxification of nitrogen compound The processes that reduce or remove the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. BP
GO:0007001 chromosome organization and biogenesis (sensu Eukaryota) The assembly and arrangement of the eukaryotic chromosomes, structures composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). BP
GO:0007000 nucleolus organization and biogenesis The assembly and arrangement of the nucleolus. BP
GO:0007007 inner mitochondrial membrane organization and biogenesis The assembly and arrangement of the mitochondrial inner membrane. BP
GO:0007006 mitochondrial membrane organization and biogenesis The assembly and arrangement of the mitochondrial membrane, the lipid bilayer surrounding a mitochondrion. BP
GO:0007005 mitochondrion organization and biogenesis The assembly and arrangement of a mitochondrion, including mitochondrial morphology and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. BP
GO:0051418 microtubule nucleation by microtubule organizing center The 'de novo' formation of a microtubule, mediated by the microtubule organizing center. BP
GO:0048792 calcium ion-independent exocytosis of neurotransmitter The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell. BP
GO:0051062 UDP reductase activity Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin. MF
GO:0052144 negative energy taxis within host The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0004091 carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. MF
GO:0052146 positive energy taxis on or near host The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052147 positive energy taxis within host The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052140 positive chemotaxis within host The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052141 positive chemotaxis on or near host The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052142 chemotaxis within host The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0004090 carbonyl reductase (NADPH) activity Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. MF
GO:0052148 modification by symbiont of host enzyme activity The process by which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052149 modification by symbiont of host protease activity The process by which an organism effects a change in host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0004092 carnitine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + carnitine = CoA + O-acetylcarnitine. MF
GO:0042912 colicin transporter activity Enables the directed movement of a colicin into, out of, within or between cells. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. MF
GO:0004097 catechol oxidase activity Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O. MF
GO:0042911 acridine transporter activity Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of, within or between cells. MF
GO:0052112 occlusion by symbiont of host xylem The process by which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0010216 maintenance of DNA methylation The processes involved in maintaining the methylation state of a nucleotide sequence. BP
GO:0010217 aluminum ion homeostasis The regulation of the levels, transport, and metabolism of aluminum ions within a cell or between a cell and its external environment. BP
GO:0010214 seed coat development The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure. BP
GO:0010215 cellulose microfibril organization Oriented deposition of cellulose microfibrils during plant cell wall biosynthesis. BP
GO:0010212 response to ionizing radiation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. BP
GO:0010213 non-photoreactive DNA repair Process involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated. BP
GO:0010210 IAA-Phe conjugate hydrolase activity Catalysis of the reaction: IAA-phenylalanine -> indole-3-acetic acid + phenylalanine. MF
GO:0010211 IAA-Leu conjugate hydrolase activity Catalysis of the reaction: IAA-leucine -> indole-3-acetic acid + leucine. MF
GO:0010218 response to far red light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a far red light stimulus. Far red light has a wavelength of around 740nm. BP
GO:0010219 regulation of vernalization response Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures. BP
GO:0005513 detection of calcium ion The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. BP
GO:0005517 calmodulin inhibitor activity NA MF
GO:0005516 calmodulin binding Interacting selectively with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. MF
GO:0005515 protein binding Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). MF
GO:0005519 cytoskeletal regulatory protein binding Interacting selectively with any protein involved in modulating the reorganization of the cytoskeleton. MF
GO:0005518 collagen binding Interacting selectively with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). MF
GO:0047447 erythro-3-hydroxyaspartate ammonia-lyase activity Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid. MF
GO:0047446 (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = cyclohexanone + acetyl-CoA. MF
GO:0047445 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = acetate + 7-methyl-3-oxooctanoyl-CoA. MF
GO:0047444 N-acylneuraminate-9-phosphate synthase activity Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate. MF
GO:0047443 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. MF
GO:0047442 17-alpha-hydroxyprogesterone aldolase activity Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. MF
GO:0047441 5-dehydro-2-deoxyphosphogluconate aldolase activity Catalysis of the reaction: 5-dehydro-2-deoxy-D-gluconate 6-phosphate = malonate semialdehyde + dihydroxy-acetone-phosphate. MF
GO:0047440 2-dehydro-3-deoxy-D-pentonate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-pentonate = glycolaldehyde + pyruvate. MF
GO:0015659 formate uptake permease activity NA MF
GO:0015658 branched-chain aliphatic amino acid transporter activity Enables the directed movement of branched-chain aliphatic amino acids, amino acids with branched carbon skeleton without rings, into, out of, within or between cells. MF
GO:0047449 2-dehydro-3-deoxy-L-arabinonate dehydratase activity Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = H2O + 2,5-dioxopentanoate. MF
GO:0047448 5-dehydro-4-deoxyglucarate dehydratase activity Catalysis of the reaction: 5-keto-4-deoxy-D-glucarate = CO2 + H2O + 2,5-dioxopentanoate. MF
GO:0043537 negative regulation of blood vessel endothelial cell migration Any process that stops, prevents or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. BP
GO:0043536 positive regulation of blood vessel endothelial cell migration Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. BP
GO:0043535 regulation of blood vessel endothelial cell migration Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. BP
GO:0043534 blood vessel endothelial cell migration The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during angiogenesis. BP
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding Interacting selectively with inositol 1,3,4,5 tetrakisphosphate. MF
GO:0043532 angiostatin binding Interacting selectively with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis. MF
GO:0043531 ADP binding Interacting selectively with ADP, adenosine 5'-diphosphate. MF
GO:0043530 adenosine 5'-monophosphoramidase activity Catalysis of the reaction: AMP-NH2 (adenosine 5'-monophosphoramidate) = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester. MF
GO:0043539 protein serine/threonine kinase activator activity Increases the activity of a protein serine/threonine kinase. MF
GO:0043538 regulation of actin phosphorylation Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule. BP
GO:0021708 Lugaro cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0021709 cerebellar basket cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0021704 locus ceruleus morphogenesis The process by which the anatomical structure of the locus ceruleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. BP
GO:0021705 locus ceruleus formation The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. BP
GO:0021706 locus ceruleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. BP
GO:0021707 cerebellar granule cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. BP
GO:0021700 developmental maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. BP
GO:0021701 cerebellar Golgi cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0021702 cerebellar Purkinje cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. BP
GO:0021703 locus ceruleus development The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. BP
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. MF
GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. MF
GO:0016303 phosphatidylinositol 3-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. MF
GO:0016300 tRNA (uracil) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. MF
GO:0016301 kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. MF
GO:0016307 phosphatidylinositol phosphate kinase activity Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. MF
GO:0046314 phosphocreatine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. BP
GO:0046315 phosphocreatine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. BP
GO:0046316 gluconokinase activity Catalysis of the reaction: ATP + D-gluconate = ADP + 6-phospho-D-gluconate. MF
GO:0046317 regulation of glucosylceramide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. BP
GO:0046310 1,3-dichloro-2-propanol catabolic process The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. BP
GO:0046311 prenylcysteine biosynthetic process The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. BP
GO:0046312 phosphoarginine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine. BP
GO:0046313 phosphoarginine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine. BP
GO:0046318 negative regulation of glucosylceramide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. BP
GO:0046319 positive regulation of glucosylceramide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide. BP
GO:0019391 glucuronoside catabolic process The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. BP
GO:0030791 arsenite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. MF
GO:0030790 chlorophenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole. MF
GO:0030793 3'-demethylstaurosporine O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine. MF
GO:0030792 methylarsonite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate. MF
GO:0030795 jasmonate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate. MF
GO:0030794 (S)-coclaurine-N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine. MF
GO:0030797 24-methylenesterol C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 24-methylenelophenol = S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol. MF
GO:0030796 cycloartenol 24-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + (24R)-24-methylcycloarta-8,25-dien-3N2-ol. MF
GO:0030799 regulation of cyclic nucleotide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. BP
GO:0030798 trans-aconitate 2-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate. MF
GO:0045159 myosin II binding Interacting selectively with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. MF
GO:0045158 electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II. MF
GO:0045157 electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis. MF
GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. MF
GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex. MF
GO:0045154 electron transporter, transferring electrons within cytochrome c oxidase complex activity Enables the directed movement of electrons within the cytochrome c oxidase complex. MF
GO:0045153 electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex. MF
GO:0045152 antisigma factor binding Interacting selectively with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator. MF
GO:0045151 acetoin biosynthetic process The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone. BP
GO:0045150 acetoin catabolic process The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone. BP
GO:0047942 glutamate-ethylamine ligase activity Catalysis of the reaction: ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine. MF
GO:0047943 glutamate-methylamine ligase activity Catalysis of the reaction: ATP + L-glutamate + methylamine = ADP + phosphate + N5-methyl-L-glutamine. MF
GO:0047940 glucuronokinase activity Catalysis of the reaction: ATP + D-glucuronate = ADP + 1-phospho-alpha-D-glucuronate. MF
GO:0047941 glucuronolactone reductase activity Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH. MF
GO:0047946 glutamine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. MF
GO:0047947 glutamine N-phenylacetyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine. MF
GO:0047944 glutamate 1-kinase activity Catalysis of the reaction: ATP + L-glutamate = ADP + alpha-L-glutamyl phosphate. MF
GO:0047945 glutamine-pyruvate transaminase activity Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine. MF
GO:0047948 glutarate-CoA ligase activity Catalysis of the reaction: ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA. MF
GO:0047949 glutarate-semialdehyde dehydrogenase activity Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH. MF
GO:0018729 propionate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA. MF
GO:0031446 regulation of striated fast muscle contraction Any process that modulates the frequency, rate or extent of striated fast muscle contraction. BP
GO:0031447 negative regulation of striated fast muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of striated fast muscle contraction. BP
GO:0031444 striated slow muscle contraction A process leading to shortening and/or development of tension in striated muscle tissue consisting entirely of slow-twitch fibers. BP
GO:0031445 striated mixed muscle contraction A process leading to shortening and/or development of tension in striated muscle tissue consisting of both fast-twitch and slow-twitch fibers. BP
GO:0031442 positive regulation of mRNA 3'-end processing Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. BP
GO:0031443 striated fast muscle contraction A process leading to shortening and/or development of tension in striated muscle tissue consisting entirely of fast-twitch fibers. BP
GO:0031440 regulation of mRNA 3'-end processing Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. BP
GO:0031441 negative regulation of mRNA 3'-end processing Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-end processing. BP
GO:0031448 positive regulation of striated fast muscle contraction Any process that activates or increases the frequency, rate or extent of striated fast muscle contraction. BP
GO:0031449 regulation of striated slow muscle contraction Any process that modulates the frequency, rate or extent of striated slow muscle contraction. BP
GO:0032230 positive regulation of synaptic transmission, GABAergic Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). BP
GO:0032231 regulation of actin filament bundle formation Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. BP
GO:0032232 negative regulation of actin filament bundle formation Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of actin filament bundles. BP
GO:0032233 positive regulation of actin filament bundle formation Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. BP
GO:0032234 regulation of calcium ion transport via store-operated calcium channel Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel. BP
GO:0032235 negative regulation of calcium ion transport via store-operated calcium channel Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel. BP
GO:0032236 positive regulation of calcium ion transport via store-operated calcium channel Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel. BP
GO:0032237 activation of store-operated calcium channel activity A process that initiates the activity of an inactive store-operated calcium channel. BP
GO:0032238 adenosine transport The directed movement of adenosine, adenine riboside, into, out of, within or between cells. BP
GO:0009615 response to virus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. BP
GO:0009616 virus induced gene silencing Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes. BP
GO:0009617 response to bacterium A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. BP
GO:0009610 response to symbiotic fungus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism. BP
GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. BP
GO:0009612 response to mechanical stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. BP
GO:0051453 regulation of cellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. BP
GO:0032498 detection of muramyl dipeptide The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan. BP
GO:0032499 detection of peptidoglycan The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule. BP
GO:0051452 cellular pH reduction Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. BP
GO:0032494 response to peptidoglycan A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of peptidoglycan. Peptidoglycan is a bacterial cell wall macromolecule. BP
GO:0032495 response to muramyl dipeptide A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of muramyl dipeptide. Muramyl dipeptide is derived from peptidoglycan. BP
GO:0032496 response to lipopolysaccharide A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of lipopolysaccharide, a major component of the cell wall of gram-negative bacteria. BP
GO:0032497 detection of lipopolysaccharide The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. BP
GO:0032490 detection of molecule of bacterial origin The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. BP
GO:0051451 myoblast migration The orderly movement of myoblasts from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. BP
GO:0032492 detection of molecule of oomycetes origin The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal. BP
GO:0032493 response to bacterial lipoprotein A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of bacterial lipoprotein. BP
GO:0051450 myoblast proliferation The multiplication or reproduction of myoblasts, resulting in the rapid expansion of a myoblast cell population. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. BP
GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. CC
GO:0051456 attachment of spindle microtubules to kinetochore during meiosis II The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs. BP
GO:0005876 spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. CC
GO:0030896 checkpoint clamp complex Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. CC
GO:0030897 HOPS complex A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p. CC
GO:0030894 replisome A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. CC
GO:0030895 apolipoprotein B mRNA editing enzyme complex Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP). CC
GO:0030892 mitotic cohesin complex A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. CC
GO:0030893 meiotic cohesin complex A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. CC
GO:0030890 positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation. BP
GO:0030891 VCB complex A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1. CC
GO:0030898 actin-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of an actin filament to accelerate release of ADP and phosphate. MF
GO:0030899 calcium-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of calcium ion (Ca2+). MF
GO:0045638 negative regulation of myeloid cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation. BP
GO:0045639 positive regulation of myeloid cell differentiation Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. BP
GO:0045632 negative regulation of mechanoreceptor differentiation Any process that stops, prevents or reduces the frequency, rate or extent of mechanoreceptor differentiation. BP
GO:0045633 positive regulation of mechanoreceptor differentiation Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation. BP
GO:0045630 positive regulation of T-helper 2 cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation. BP
GO:0045631 regulation of mechanoreceptor differentiation Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation. BP
GO:0045636 positive regulation of melanocyte differentiation Any process that activates or increases the frequency, rate or extent of melanocyte differentiation. BP
GO:0045637 regulation of myeloid cell differentiation Any process that modulates the frequency, rate or extent of myeloid cell differentiation. BP
GO:0045634 regulation of melanocyte differentiation Any process that modulates the frequency, rate or extent of melanocyte differentiation. BP
GO:0045635 negative regulation of melanocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of melanocyte differentiation. BP
GO:0047168 isocitrate O-dihydroxycinnamoyltransferase activity Catalysis of the reaction: threo-d(s)-iso-citrate + caffeoyl-CoA = 2-caffeoylisocitrate + CoA. MF
GO:0047169 galactarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: feruloyl-CoA + D-galactarate = O-feruloylgalactarate + CoA. MF
GO:0047164 isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA. MF
GO:0047165 flavonol-3-O-beta-glucoside O-malonyltransferase activity Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA. MF
GO:0047166 1-alkenylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA. MF
GO:0047167 1-alkyl-2-acetylglycerol O-acyltransferase activity Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA. MF
GO:0047160 alkylglycerophosphate 2-O-acetyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA. MF
GO:0047161 tartronate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: 2-hydroxymalonate + sinapoyl-CoA = sinapoyltartronate + CoA. MF
GO:0047162 17-O-deacetylvindoline O-acetyltransferase activity Catalysis of the reaction: 17-O-deacetylvindoline + acetyl-CoA = vindoline + CoA. MF
GO:0047163 3,4-dichloroaniline N-malonyltransferase activity Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonate + CoA. MF
GO:0006220 pyrimidine nucleotide metabolic process The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0006222 UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. BP
GO:0006223 uracil salvage Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. BP
GO:0006225 UDP biosynthetic process The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate. BP
GO:0006226 dUMP biosynthetic process The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). BP
GO:0006227 dUDP biosynthetic process The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate). BP
GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. BP
GO:0006229 dUTP biosynthetic process The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate. BP
GO:0047099 CDP-4-dehydro-6-deoxyglucose reductase activity Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose. MF
GO:0001634 pituitary adenylate cyclase activating protein receptor activity NA MF
GO:0001635 calcitonin gene-related polypeptide receptor activity NA MF
GO:0031859 platelet activating factor receptor binding Interacting selectively with a platelet activating factor receptor. MF
GO:0031858 pituitary adenylate cyclase-activating peptide receptor binding Interacting selectively with a pituitary adenylate cyclase-activating peptide receptor. MF
GO:0001639 PLC activating metabotropic glutamate receptor activity A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system. MF
GO:0031851 kappa-type opioid receptor binding Interacting selectively with a kappa-type opioid receptor. MF
GO:0031850 delta-type opioid receptor binding Interacting selectively with a delta-type opioid receptor. MF
GO:0031853 nociceptin receptor binding Interacting selectively with a nociceptin receptor. MF
GO:0031852 mu-type opioid receptor binding Interacting selectively with a mu-type opioid receptor. MF
GO:0031855 oxytocin receptor binding Interacting selectively with an oxytocin receptor. MF
GO:0031854 orexigenic neuropeptide QRFP receptor binding Interacting selectively with an orexigenic neuropeptide QRFP receptor. MF
GO:0031857 type 1 parathyroid hormone receptor binding Interacting selectively with a type 1 parathyroid hormone receptor. MF
GO:0031856 parathyroid hormone receptor binding Interacting selectively with a parathyroid hormone receptor. MF
GO:0050748 negative regulation of lipoprotein metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. BP
GO:0050749 apolipoprotein E receptor binding Interacting selectively with an apolipoprotein E receptor. MF
GO:0050740 protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine. BP
GO:0050741 protein-FMN linkage via O3-riboflavin phosphoryl-L-serine The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine. BP
GO:0050742 protein-FMN linkage via S-(4a-FMN)-L-cysteine The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine. BP
GO:0050743 protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine. BP
GO:0050744 protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine. BP
GO:0050745 peptide cross-linking via L-cysteinyl-5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. BP
GO:0050746 regulation of lipoprotein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. BP
GO:0050747 positive regulation of lipoprotein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. BP
GO:0048921 posterior lateral line neuromast cupula development The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. BP
GO:0005750 respiratory chain complex III (sensu Eukaryota) A part of the respiratory chain, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0048923 posterior lateral line neuromast hair cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. BP
GO:0048922 posterior lateral line neuromast deposition The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line. BP
GO:0048925 lateral line system development The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear. BP
GO:0048924 posterior lateral line neuromast mantle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. BP
GO:0048927 posterior lateral line neuromast support cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. BP
GO:0048926 electrosensory lateral line system development The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure. BP
GO:0048929 efferent axon development in the posterior lateral line nerve The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve. BP
GO:0048928 posterior lateral line ganglion neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion. BP
GO:0004486 methylenetetrahydrofolate dehydrogenase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. MF
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+. MF
GO:0004484 mRNA guanylyltransferase activity Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. MF
GO:0004485 methylcrotonoyl-CoA carboxylase activity Catalysis of the reaction: ATP + 3-methylcrotonyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA. MF
GO:0004482 mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. MF
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. MF
GO:0004481 methylene-fatty-acyl-phospholipid synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid. MF
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+. MF
GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. MF
GO:0048699 generation of neurons The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. BP
GO:0048698 negative regulation of collateral sprouting in the absence of injury Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting in the absence of injury. BP
GO:0002636 positive regulation of germinal center formation Any process that activates or increases the frequency, rate, or extent of germinal center formation. BP
GO:0048693 regulation of collateral sprouting of injured axon Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon. BP
GO:0048692 negative regulation of axon extension involved in regeneration Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in regeneration. BP
GO:0048691 positive regulation of axon extension involved in regeneration Any process that activates, maintains or increases the rate of axon extension involved in regeneration. BP
GO:0048690 regulation of axon extension involved in regeneration Any process that modulates the frequency, rate or extent of axon extension involved in regeneration. BP
GO:0048697 positive regulation of collateral sprouting in the absence of injury Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury. BP
GO:0048696 regulation of collateral sprouting in the absence of injury Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury. BP
GO:0048695 negative regulation of collateral sprouting of injured axon Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting of an injured axon. BP
GO:0048694 positive regulation of collateral sprouting of injured axon Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon. BP
GO:0002255 tissue kallikrein-kinin cascade A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. BP
GO:0002254 kinin cascade A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. BP
GO:0002257 negative regulation of kinin cascade Any process that stops, prevents or reduces the frequency, rate, or extent of the kinin cascade. BP
GO:0002256 regulation of kinin cascade Any process that modulates the frequency, rate, or extent of the kinin cascade. BP
GO:0002251 organ or tissue specific immune response An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. BP
GO:0002250 adaptive immune response An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). BP
GO:0002253 activation of immune response Any process that initiates an immune response. BP
GO:0002252 immune effector process Any process of the immune system that occurs as part of an immune response. BP
GO:0002259 endothelial cell activation within high endothelial venule during immune response A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. BP
GO:0002258 positive regulation of kinin cascade Any process that activates or increases the frequency, rate, or extent of the kinin cascade. BP
GO:0007599 hemostasis The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. BP
GO:0007598 blood coagulation, extrinsic pathway A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway. BP
GO:0007595 lactation The secretion of milk by the mammary gland. BP
GO:0007594 puparial adhesion The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation. BP
GO:0007597 blood coagulation, intrinsic pathway A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid. BP
GO:0002630 positive regulation of proteolysis associated with antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. BP
GO:0007591 molting cycle (sensu Insecta) The periodic shedding of part or all of a cuticle, which is then replaced by a new cuticle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007593 cuticle tanning The cross-linking of chitin and other cuticle proteins, rendering them insoluble and hardening the cuticle. This process generally darkens the color of the cuticle. BP
GO:0007592 cuticle biosynthetic process (sensu Protostomia and Nematoda) Synthesis and deposition of a noncellular, hardened, or membranous secretion from an epithelial sheet. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317), and the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0001501 skeletal development The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). BP
GO:0001502 cartilage condensation The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. BP
GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. BP
GO:0001504 neurotransmitter uptake The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft. BP
GO:0001505 regulation of neurotransmitter levels Any process that modulates levels of neurotransmitter. BP
GO:0001507 acetylcholine catabolic process in synaptic cleft The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission. BP
GO:0001508 regulation of action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. BP
GO:0001509 legumain activity Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds. MF
GO:0004158 dihydroorotate oxidase activity Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. MF
GO:0004159 dihydrouracil dehydrogenase (NAD+) activity Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+. MF
GO:0004150 dihydroneopterin aldolase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. MF
GO:0004151 dihydroorotase activity Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. MF
GO:0004152 dihydroorotate dehydrogenase activity Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. MF
GO:0004153 dihydropterin deaminase activity Catalysis of the reaction: 7,8-dihydropterin + H20 = 7,8-dihydrolumazine + NH3. MF
GO:0004154 dihydropterin oxidase activity Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + H2O2. MF
GO:0004155 6,7-dihydropteridine reductase activity Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. MF
GO:0004156 dihydropteroate synthase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. MF
GO:0004157 dihydropyrimidinase activity Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. MF
GO:0032203 telomere formation via telomerase The addition of telomeric repeats to a non-telomeric double-stranded DNA end by telomerase. BP
GO:0001984 vasodilation of artery during baroreceptor response to increased blood pressure An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure. BP
GO:0001985 negative regulation of heart contraction rate in baroreceptor response to increased blood pressure Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure. BP
GO:0008668 (2,3-dihydroxybenzoyl)adenylate synthase activity Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate. MF
GO:0021542 dentate gyrus development The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. BP
GO:0021543 pallium development The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. BP
GO:0021540 corpus callosum morphogenesis The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres. BP
GO:0008669 2,3-dihydroxy-phenylpropionate 1,2-dioxygenase activity NA MF
GO:0021546 rhombomere development The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. BP
GO:0021547 midbrain-hindbrain boundary initiation The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. BP
GO:0021544 subpallium development The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. BP
GO:0021545 cranial nerve development The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. BP
GO:0001980 ischemic regulation of blood pressure The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system. BP
GO:0021548 pons development The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. BP
GO:0021549 cerebellum development The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. BP
GO:0052493 negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction. BP
GO:0001982 baroreceptor response to lowering of blood pressure The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery. BP
GO:0008662 1-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate. MF
GO:0043653 mitochondrial fragmentation during apoptosis The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form. BP
GO:0008660 1-aminocyclopropane-1-carboxylate deaminase activity Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3. MF
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. MF
GO:0043656 intracellular region of host That space within the plasma membrane of a host cell. CC
GO:0043657 host cell A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope. CC
GO:0043654 recognition of apoptotic cell The process by which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis. BP
GO:0043655 extracellular space of host The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream. CC
GO:0035010 encapsulation of foreign target Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization. BP
GO:0030030 cell projection organization and biogenesis The assembly and arrangement of a prolongation or process extending from a cell, e.g. a flagellum or axon. BP
GO:0030031 cell projection biogenesis Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. BP
GO:0030032 lamellipodium biogenesis Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. BP
GO:0015927 trehalase activity Catalysis of the hydrolysis of trehalose or a trehalose derivative. MF
GO:0015926 glucosidase activity Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. MF
GO:0015925 galactosidase activity Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. MF
GO:0035045 sperm plasma membrane disassembly The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg. BP
GO:0015923 mannosidase activity Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. MF
GO:0015922 aspartate oxidase activity Catalysis of the reaction: aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2. MF
GO:0015921 lipopolysaccharide export The directed movement of lipopolysaccharides out of a cell or organelle. BP
GO:0015920 lipopolysaccharide transport The directed movement of lipopolysaccharides into, out of, within or between cells. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. BP
GO:0035042 fertilization, exchange of chromosomal proteins Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity. BP
GO:0015929 hexosaminidase activity Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. MF
GO:0035043 male pronuclear envelope synthesis Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation. BP
GO:0030036 actin cytoskeleton organization and biogenesis The assembly and arrangement of cytoskeletal structures comprising actin filaments and their associated proteins. BP
GO:0035041 sperm chromatin decondensation Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus. BP
GO:0051624 inhibition of norepinephrine uptake Any process that prevents the activation of the directed movement of norepinephrine into a cell. BP
GO:0051625 epinephrine uptake The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. BP
GO:0051626 regulation of epinephrine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell. BP
GO:0051627 negative regulation of epinephrine uptake Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell. BP
GO:0051620 norepinephrine uptake The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. BP
GO:0051621 regulation of norepinephrine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. BP
GO:0051622 negative regulation of norepinephrine uptake Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. BP
GO:0051623 positive regulation of norepinephrine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. BP
GO:0051628 positive regulation of epinephrine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell. BP
GO:0051629 inhibition of epinephrine uptake Any process that prevents the activation of the directed movement of epinephrine into a cell. BP
GO:0050530 glucosylglycerol 3-phosphatase activity Catalysis of the reaction: 2-(beta-D-glucosyl)-sn-glycerol-3-phosphate + H2O = 2-(beta-D-glucosyl)-sn-glycerol + phosphate. MF
GO:0006149 deoxyinosine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside. BP
GO:0006148 inosine catabolic process The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. BP
GO:0006141 regulation of purine base metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines. BP
GO:0006140 regulation of nucleotide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. BP
GO:0006142 regulation of pyrimidine base metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidines. BP
GO:0006145 purine base catabolic process The chemical reactions and pathways resulting in the breakdown of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. BP
GO:0006144 purine base metabolic process The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. BP
GO:0006147 guanine catabolic process The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. BP
GO:0006146 adenine catabolic process The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. BP
GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. MF
GO:0008106 alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. MF
GO:0008105 asymmetric protein localization The processes by which a protein is transported to, or maintained in, a specific asymmetric distribution. BP
GO:0008104 protein localization The processes by which a protein is transported to, or maintained in, a specific location. BP
GO:0008103 oocyte microtubule cytoskeleton polarization Establishment and maintenance of an axis of polarity of the oocyte microtubule network such that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. BP
GO:0008101 decapentaplegic receptor signaling pathway The series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands. BP
GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. MF
GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity Catalysis of the reaction: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. MF
GO:0022038 corpus callosum development The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. BP
GO:0022033 telencephalon microglial cell migration The orderly movement of microglial cells through the telencephalon. BP
GO:0022032 telencephalon oligodendrocyte cell migration The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the rapid expansion of a cell population. BP
GO:0022031 telencephalon astrocyte cell migration The orderly movement of astrocyte cells through the telencephalon. BP
GO:0022030 telencephalon glial cell migration The orderly movement of glial cells through the telencephalon. BP
GO:0022037 metencephalon development The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. BP
GO:0022036 rhombomere cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a rhombomere cell. BP
GO:0022035 rhombomere cell migration The movement of cells within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. BP
GO:0022034 rhombomere cell proliferation The multiplication or reproduction of rhombomere cells, resulting in the rapid expansion of the cell population. BP
GO:0047762 caffeate 3,4-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxy-trans-cinnamate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate. MF
GO:0047763 caffeate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate. MF
GO:0047760 butyrate-CoA ligase activity Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA. MF
GO:0047761 butyrate kinase activity Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate. MF
GO:0047766 carbamoyl-serine ammonia-lyase activity Catalysis of the reaction: O-carbamoyl-L-serine + H2O = pyruvate + 2 NH3 + CO2. MF
GO:0047764 caldesmon kinase activity Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate. MF
GO:0047765 caldesmon-phosphatase activity Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate. MF
GO:0047768 carboxy-cis,cis-muconate cyclase activity Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate. MF
GO:0047769 carboxycyclohexadienyl dehydratase activity Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2. MF
GO:0043472 IgD binding Interacting selectively with an immunoglobulin of a D isotype. MF
GO:0043473 pigmentation The deposition or aggregation of coloring matter in an organism, tissue or cell. BP
GO:0043470 regulation of carbohydrate catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. BP
GO:0043471 regulation of cellular carbohydrate catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. BP
GO:0043476 pigment accumulation The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. BP
GO:0043477 pigment biosynthetic process during pigment accumulation The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, occurring during pigment accumulation. BP
GO:0043474 pigment metabolic process during pigmentation The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, occurring during the deposition or aggregation of pigment in an organism, tissue or cell. BP
GO:0043475 pigment metabolic process during pigment accumulation The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, occurring during pigment accumulation. BP
GO:0043478 pigment accumulation in response to UV light The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus. BP
GO:0043479 pigment accumulation in tissues in response to UV light The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus. BP
GO:0016405 CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. MF
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. MF
GO:0016407 acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule. MF
GO:0016406 carnitine O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. MF
GO:0016401 palmitoyl-CoA oxidase activity Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + H2O2. MF
GO:0016403 dimethylargininase activity Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. MF
GO:0016402 pristanoyl-CoA oxidase activity Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + H2O2. MF
GO:0016409 palmitoyltransferase activity Catalysis of the transfer of an palmitoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. MF
GO:0016408 C-acyltransferase activity Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. MF
GO:0006065 UDP-glucuronate biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. BP
GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity A TGFbeta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The heterocomplex translocates to the nucleus to regulate transcription. MF
GO:0030619 U1 snRNA binding Interacting selectively with the U1 small nuclear RNA (U1 snRNA). MF
GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide. MF
GO:0030616 transforming growth factor beta receptor, common-partner cytoplasmic mediator activity A TGFbeta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription. MF
GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity A TGFbeta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators. MF
GO:0030611 arsenate reductase activity Catalysis of the interconversion of arsenate and arsenite. MF
GO:0030612 arsenate reductase (thioredoxin) activity Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is NADPH -> thioredoxin reductase -> thioredoxin -> arsenate reductase. MF
GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0042765 GPI-anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. CC
GO:0042764 prospore A spore, of the type seen in some species of fungi and protist, undergoing development, usually consisting of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). CC
GO:0042767 ecdysteroid 22-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 22. MF
GO:0045058 T cell selection The process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. BP
GO:0042766 nucleosome mobilization The movement of nucleosomes along a DNA fragment. BP
GO:0045052 protein insertion into ER membrane by GPI attachment sequence The insertion of integral proteins into the endoplasmic reticulum membrane. Proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule. BP
GO:0042761 very-long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of C18 or greater. BP
GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence The insertion of integral proteins into the endoplasmic reticulum membrane. Stop-transfer membrane-anchor sequences become an ER membrane spanning helix. BP
GO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence The insertion of integral proteins into the endoplasmic reticulum membrane. Signal anchor sequences function as both ER signal sequences and membrane anchor sequences. BP
GO:0045056 transcytosis The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. BP
GO:0045057 cisternal progression The process by which a new cis-Golgi stack physically moves from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna. BP
GO:0045054 constitutive secretory pathway The constitutive pathway required by all cells, along which substances are moved around and out of the cell. Transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. The membrane proteins and the lipids in these vesicles provide new components for the plasma membrane, while the soluble proteins inside the vesicles are secreted to the extracellular space by exocytosis. BP
GO:0042760 very-long-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of C18 or greater. BP
GO:0042763 immature spore A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants. CC
GO:0042762 regulation of sulfur metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. BP
GO:0018838 mandelate racemase activity Catalysis of the reaction: (S)-mandelate = (R)-mandelate. MF
GO:0018839 cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. MF
GO:0018836 alkylmercury lyase activity Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+. MF
GO:0018837 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate. MF
GO:0018834 dichloromethane dehalogenase activity Catalysis of the reaction: dichloromethane + H2O = formaldehyde + 2 chloride. MF
GO:0018835 carbon phosphorus lyase activity Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate). MF
GO:0018832 halohydrin hydrogen-halide-lyase B activity Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane. MF
GO:0018833 DDT-dehydrochlorinase activity Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + chloride. MF
GO:0018830 gamma-hexachlorocyclohexane dehydrochlorinase activity Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene. MF
GO:0018831 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone. MF
GO:0010253 UDP-rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate. BP
GO:0002475 antigen processing and presentation via MHC class Ib The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. BP
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. BP
GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0002471 monocyte antigen processing and presentation The process by which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0002470 plasmacytoid dendritic cell antigen processing and presentation The process by which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0002473 non-professional antigen presenting cell antigen processing and presentation The process by which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils. BP
GO:0002472 macrophage antigen processing and presentation The process by which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules. BP
GO:0002478 antigen processing and presentation of exogenous peptide antigen The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. BP
GO:0006388 tRNA splicing Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. BP
GO:0006387 snRNA capping NA BP
GO:0006386 transcription termination from RNA polymerase III promoter The process by which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues. BP
GO:0006385 RNA elongation from RNA polymerase III promoter The extension of an RNA molecule after transcription initiation at an RNA polymerase III-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase III. BP
GO:0006384 transcription initiation from RNA polymerase III promoter NA BP
GO:0006383 transcription from RNA polymerase III promoter The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter. BP
GO:0006382 adenosine to inosine editing The conversion of an adenosine residue to inosine in an RNA molecule by deamination. BP
GO:0006381 mRNA editing The insertion, deletion or substitution of nucleotides within nascent mRNA transcripts to produce mRNA molecules with sequences that differ from those coded genetically. BP
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat5 protein. BP
GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat5 protein. BP
GO:0042521 negative regulation of tyrosine phosphorylation of Stat4 protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat4 protein. BP
GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat4 protein. BP
GO:0042527 negative regulation of tyrosine phosphorylation of Stat6 protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat6 protein. BP
GO:0042526 positive regulation of tyrosine phosphorylation of Stat6 protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat6 protein. BP
GO:0042525 regulation of tyrosine phosphorylation of Stat6 protein Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat6 protein. BP
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat5 protein. BP
GO:0042529 positive regulation of tyrosine phosphorylation of Stat7 protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat7 protein. BP
GO:0042528 regulation of tyrosine phosphorylation of Stat7 protein Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat7 protein. BP
GO:0048716 labrum morphogenesis The process by which the anatomical structures of labrum are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048717 anterior cibarial plate morphogenesis The process by which the anatomical structures of anterior cibarial plate are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048714 positive regulation of oligodendrocyte differentiation Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. BP
GO:0048715 negative regulation of oligodendrocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte differentiation. BP
GO:0048712 negative regulation of astrocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte differentiation. BP
GO:0048713 regulation of oligodendrocyte differentiation Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. BP
GO:0048710 regulation of astrocyte differentiation Any process that modulates the frequency, rate or extent of astrocyte differentiation. BP
GO:0048711 positive regulation of astrocyte differentiation Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. BP
GO:0048718 fish trap bristle morphogenesis The process by which the anatomical structures of fish trap bristle are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048719 epistomal sclerite morphogenesis The process by which the anatomical structures of epistomal sclerite are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0004839 ubiquitin activating enzyme activity Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner. MF
GO:0004838 tyrosine transaminase activity Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate. MF
GO:0004833 tryptophan 2,3-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = L-formylkynurenine. MF
GO:0004832 valine-tRNA ligase activity Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). MF
GO:0004831 tyrosine-tRNA ligase activity Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). MF
GO:0004830 tryptophan-tRNA ligase activity Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). MF
GO:0004837 tyrosine decarboxylase activity Catalysis of the reaction: L-tyrosine = tyramine + CO2. MF
GO:0004836 tyramine-beta hydroxylase activity Catalysis of the hydroxylation of tyramine to form octopamine. MF
GO:0004835 tubulin-tyrosine ligase activity Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. MF
GO:0004834 tryptophan synthase activity Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. MF
GO:0051004 regulation of lipoprotein lipase activity Any process that modulates the activity of the enzyme lipoprotein lipase. BP
GO:0051005 negative regulation of lipoprotein lipase activity Any process that stops or reduces the activity of the enzyme lipoprotein lipase. BP
GO:0051006 positive regulation of lipoprotein lipase activity Any process that activates or increases the activity of the enzyme lipoprotein lipase. BP
GO:0051007 squalene-hopene cyclase activity Catalysis of the reaction: squalene = hop-22(29)-ene. MF
GO:0051000 positive regulation of nitric-oxide synthase activity Any process that activates or increases the activity of the enzyme nitric-oxide synthase. BP
GO:0051001 negative regulation of nitric-oxide synthase activity Any process that stops or reduces the activity of the enzyme nitric-oxide synthase. BP
GO:0051002 ligase activity, forming nitrogen-metal bonds Catalysis of the ligation of two substances via a nitrogen-metal bond. MF
GO:0051003 ligase activity, forming nitrogen-metal bonds, forming coordination complexes Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex. MF
GO:0007411 axon guidance The process by which the migration of an axon growth cone is directed to a specific target site in response to a combination of attractive and repulsive cues. BP
GO:0007412 axon target recognition The process by which an axon recognizes and binds to a set of cells with which it may form stable connections. BP
GO:0007413 axonal fasciculation The collection of axons into a bundle of rods, known as a fascicle. BP
GO:0051008 Hsp27 protein binding Interacting selectively with Hsp27 proteins, a lightweight heat shock protein. MF
GO:0051009 O-acetylhomoserine sulfhydrylase activity Catalysis of the reaction: O-acetyl-L-homoserine + H2S = homocysteine + acetate. MF
GO:0007416 synaptogenesis The biosynthesis of a synapse. BP
GO:0007417 central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. BP
GO:0010164 response to cesium A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. BP
GO:0010165 response to X-ray A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). BP
GO:0018319 protein amino acid myristoylation The covalent or non-covalent attachment of a myristoyl moiety to a protein amino acid. BP
GO:0018318 protein amino acid palmitoylation The covalent or non-covalent attachment of a palmitoyl moiety to a protein amino acid. BP
GO:0010160 formation of organ boundary The regionalization process that specificies organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. BP
GO:0010161 red light signaling pathway The series of molecular signals initiated upon sensing of red light by photoreceptor molecule at 660 nm. BP
GO:0010162 seed dormancy The process by which a dormant state is induced and maintained in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated once dormancy is broken. BP
GO:0010163 high affinity potassium ion import The directed, energized, high affinity movement of potassium ions into a cell or organelle, driven by cation symport with hydrogen or sodium ions. BP
GO:0018313 peptide cross-linking via L-alanyl-5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. BP
GO:0018312 peptidyl-serine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine. BP
GO:0018311 peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine. BP
GO:0018310 protein-FMN linkage via S-(6-FMN)-L-cysteine The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine. BP
GO:0018317 protein amino acid C-linked glycosylation via tryptophan The glycosylation of a carbon atom of a peptidyl-tryptophan residue. BP
GO:0051914 positive regulation of synaptic plasticity by chemical substance The process by which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require. BP
GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex The incorporation of molybdenum into a molybdenum-molybdopterin complex. BP
GO:0017092 sterol regulatory element-binding protein site 2 protease activity Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding-protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus. MF
GO:0017095 heparan sulfate 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. MF
GO:0017094 sterol regulatory element-binding protein site 1 protease activity Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding-protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves. MF
GO:0017097 acetylserotonin N-methyltransferase activity NA MF
GO:0017096 acetylserotonin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin (N-acetyl-5-methoxytryptamine). MF
GO:0001711 endodermal cell fate commitment The process by which a cell becomes committed to become part of the endoderm. BP
GO:0001710 mesodermal cell fate commitment The process by which a cell becomes committed to become part of the mesoderm. BP
GO:0001713 ectodermal cell fate determination Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0001712 ectodermal cell fate commitment The process by which a cell becomes committed to become part of the ectoderm. BP
GO:0001715 ectodermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0001714 endodermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec Process whereby serine carried by a specialized tRNA(ser) (which can read a UGA anticodon) is converted to selenocysteine. BP
GO:0001716 L-amino-acid oxidase activity Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2. MF
GO:0001718 conversion of met-tRNAf to fmet-tRNA The process whereby methionine carried by an initiator methionine tRNA is N-formylated. BP
GO:0016649 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound. MF
GO:0016648 oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide. MF
GO:0016643 oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. MF
GO:0016642 oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group. MF
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. MF
GO:0016640 oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule. MF
GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen. MF
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. MF
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0021977 tectospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord. BP
GO:0021976 medulla reticulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord. BP
GO:0021975 pons reticulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord. BP
GO:0021974 trigeminothalamic tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal processes is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face. BP
GO:0021973 corticospinal neuron axon decussation The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side. BP
GO:0021972 corticospinal neuron axon guidance through the spinal cord The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues. BP
GO:0021971 corticospinal neuron axon guidance through the medullary pyramid The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues. BP
GO:0021970 corticospinal neuron axon guidance through the basilar pons The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues. BP
GO:0021979 hypothalamus cell differentiation The differentiation of cells that will contribute to the structure and function of the hypothalamus. BP
GO:0021978 telencephalon regionalization The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. BP
GO:0052069 negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052068 negative regulation by symbiont of host jasmonic acid-mediated defense response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052067 negative regulation by symbiont of entry into host cell via phagocytosis Any process by which an organism stops or prevents itself undergoing phagocytosis into a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052066 entry of symbiont into host cell by promotion of host phagocytosis The invasion by an organism of a cell of its host organism by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052065 positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052064 induction by symbiont of defense-related host reactive oxygen species production The activation by an organism of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052063 induction by symbiont of defense-related host nitric oxide production The activation by an organism of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052062 induction by symbiont of host phytoalexin production The activation by an organism of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052061 evasion or tolerance by symbiont of host-produced phytoalexins The process by which an organism avoids the effects of phytoalexins produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052060 evasion or tolerance by symbiont of host-produced nitric oxide The process by which an organism avoids the effects of nitric oxide produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0019192 fructose porter activity NA MF
GO:0019193 sorbose porter activity NA MF
GO:0019190 cellobiose permease activity NA MF
GO:0019191 cellobiose transporter activity Enables the directed movement of cellobiose into, out of, within or between cells. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. MF
GO:0019196 galactosamine transporter activity Enables the directed movement of galactosamine into, out of, within or between cells. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative. MF
GO:0019197 phosphoenolpyruvate-dependent sugar phosphotransferase complex Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system). CC
GO:0019194 sorbose transporter activity Enables the directed movement of sorbose into, out of, within or between cells. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. MF
GO:0019195 galactosamine porter activity Catalysis of the movement of galactosamine by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. MF
GO:0019198 transmembrane receptor protein phosphatase activity The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner. MF
GO:0019199 transmembrane receptor protein kinase activity NA MF
GO:0031107 septin ring disassembly The controlled breakdown of a septin ring. BP
GO:0031106 septin ring organization Control of the formation, spatial distribution, and breakdown of the septin ring. BP
GO:0031105 septin complex Any of several heterooligomeric complexes containing multiple septins. CC
GO:0031104 dendrite regeneration The regrowth of dendrites following their loss or damage. BP
GO:0031103 axon regeneration The regrowth of axons following their loss or damage. BP
GO:0031102 neurite regeneration The regrowth of neuronal processes such as axons or dendrites following their loss or damage. BP
GO:0031101 fin regeneration The regrowth of fin tissue following its loss or destruction. BP
GO:0031100 organ regeneration The regrowth of a lost or destroyed organ. BP
GO:0031109 microtubule polymerization or depolymerization Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. BP
GO:0031108 holo-[acyl-carrier-protein] biosynthetic process The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]. BP
GO:0051783 regulation of nuclear division Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. BP
GO:0051782 negative regulation of cell division Any process that stops, prevents or reduces the frequency, rate or extent of cell division. BP
GO:0051781 positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division. BP
GO:0051780 behavioral response to nutrient A change in the behavior of an organism as a result of a nutrient stimulus. BP
GO:0051787 misfolded protein binding Interacting selectively with a misfolded protein. MF
GO:0051786 all-trans-retinol 13,14-reductase activity Catalysis of the reaction: all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor. Note that this reaction has only been observed to occur in the opposite direction. MF
GO:0051785 positive regulation of nuclear division Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. BP
GO:0051784 negative regulation of nuclear division Any process that stops, prevents or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. BP
GO:0051789 response to protein stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus. BP
GO:0051788 response to misfolded protein A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. BP
GO:0051875 pigment granule localization The processes by which a pigment granule is transported to, and/or maintained in, a specific location within the cell. BP
GO:0051874 sphinganine-1-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. BP
GO:0051877 pigment granule aggregation in cell center The directed movement of dispersed pigment granules towards the center of the cell. BP
GO:0051876 pigment granule dispersal The directed movement of pigment granules within a cell towards the cell periphery. BP
GO:0051871 dihydrofolic acid binding Interacting selectively with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms. MF
GO:0051870 methotrexate binding Interacting selectively with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. MF
GO:0051873 killing by host of symbiont cells Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051872 sphingosine catabolic process The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. BP
GO:0051879 Hsp90 protein binding Interacting selectively with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. MF
GO:0051878 lateral element assembly The cell cycle process whereby lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements. BP
GO:0008734 L-aspartate oxidase activity Catalysis of the reaction: L-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2. MF
GO:0008735 carnitine dehydratase activity Catalysis of the reaction: L-carnitine = 4-(trimethylammonio)but-2-enoate + H2O. MF
GO:0008736 L-fucose isomerase activity Catalysis of the reaction: L-fucose = L-fuculose. MF
GO:0008737 L-fuculokinase activity Catalysis of the reaction: ATP + L-fuculose = ADP + L-fuculose 1-phosphate. MF
GO:0008730 L(+)-tartrate dehydratase activity Catalysis of the reaction: (R,R)-tartrate = oxaloacetate + H2O. MF
GO:0008732 L-allo-threonine aldolase activity NA MF
GO:0008733 L-arabinose isomerase activity Catalysis of the reaction: L-arabinose = L-ribulose. MF
GO:0008738 L-fuculose-phosphate aldolase activity Catalysis of the reaction: L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. MF
GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. BP
GO:0045448 mitotic cell cycle, embryonic The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo. BP
GO:0045445 myoblast differentiation The process whereby a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a cell type that gives rise to mature contractile cells called myocytes. Fusion of myoblasts gives rise to the myotubes that eventually develop into skeletal muscle fibers. BP
GO:0045444 fat cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. BP
GO:0045446 endothelial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. BP
GO:0045441 deacetoxycephalosporin C synthetase activity Catalysis of the formation of deacetoxycephalosporin from penicillin-N. MF
GO:0045443 juvenile hormone secretion The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. BP
GO:0045442 deacetoxycephalosporin C hydroxylase activity Catalysis of the hydroxylation of deacetoxycephalosporin C in the 3' position to form deacetylcephalosporin C. MF
GO:0045189 connective tissue growth factor biosynthetic process The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGFbeta. BP
GO:0047357 UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + UDP-galactose = UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP. MF
GO:0047356 CDP-ribitol ribitolphosphotransferase activity Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP. MF
GO:0047355 CDP-glycerol glycerophosphotransferase activity Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP. MF
GO:0047354 sphingosine cholinephosphotransferase activity Catalysis of the reaction: sphingosine + CDP-choline = sphingosyl-phosphocholine + CMP. MF
GO:0047353 N-methylphosphoethanolamine cytidylyltransferase activity Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamin + diphosphate. MF
GO:0047352 adenylylsulfate-ammonia adenylyltransferase activity Catalysis of the reaction: NH3 + APS = SO4(2-) (sulfate) + adenosine 5'-phosphoramidate. MF
GO:0047351 guanosine-triphosphate guanylyltransferase activity Catalysis of the reaction: 2 GTP = P1,P4-bis(5'-guanosyl) tetraphosphate + diphosphate. MF
GO:0047350 glucuronate-1-phosphate uridylyltransferase activity Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = UDP-D-glucuronate + diphosphate. MF
GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP. MF
GO:0047358 UDP-glucose-glycoprotein glucose phosphotransferase activity Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP. MF
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. MF
GO:0046405 glycerol dehydratase activity Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. MF
GO:0046406 magnesium protoporphyrin IX methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + magnesium protoporphyrin = S-adenosyl-L-homocysteine + magnesium protoporphyrin monomethyl ester. MF
GO:0046407 chlorophyll a oxygenase activity Catalysis of the reaction: chlorophyll a + O2 + NADP+ + H+ = chlorophyll b + H2O + NADPH + H+. MF
GO:0046400 ketodeoxyoctanoate metabolic process The chemical reactions and pathways involving ketodeoxyoctanoate, 2-keto-3-deoxy-D-octaonate, an acid present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. BP
GO:0046401 lipopolysaccharide core region metabolic process The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains. BP
GO:0046402 O antigen metabolic process The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. BP
GO:0046403 polynucleotide 3'-phosphatase activity Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. MF
GO:0046408 chlorophyll synthetase activity Catalysis of the esterification reaction: chlorophyllide a + phytyl pyrophosphate = chlorophyll a + pyrophosphate. MF
GO:0046409 p-coumarate 3-hydroxylase activity Catalysis of the 3-hydroxylation reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H20 + NADP+. MF
GO:0035169 lymph gland plasmatocyte differentiation The process whereby a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. BP
GO:0035168 lymph gland hemocyte differentiation (sensu Arthropoda) The process whereby a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035165 embryonic crystal cell differentiation The process whereby an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. BP
GO:0035164 embryonic plasmatocyte differentiation The process whereby an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. BP
GO:0035167 lymph gland hemopoiesis (sensu Arthropoda) The production of blood cells from the larval lymph gland. Lymph glands in Drosophila are a hematopoietic organ composed of paired lobes located along the dorsal vessel. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035166 post-embryonic hemopoiesis The stages of blood cell formation that take place after completion of embryonic development. BP
GO:0035161 imaginal disc lineage restriction Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment. BP
GO:0035160 maintenance of tracheal epithelial integrity Ensuring that tracheal tubes maintain their epithelial structure during the cell shape changes and movements that occur during the branching process. BP
GO:0035163 embryonic hemocyte differentiation (sensu Arthropoda) The process whereby a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035162 embryonic hemopoiesis The stages of blood cell formation that take place within the embryo. BP
GO:0048554 positive regulation of metalloenzyme activity Any process that activates, maintains or increases the rate activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal. BP
GO:0048555 generative cell nucleus The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells. CC
GO:0048556 microsporocyte nucleus The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte. CC
GO:0048557 embryonic digestive tract morphogenesis The process by which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines. BP
GO:0048550 negative regulation of pinocytosis Any process that stops, prevents or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. BP
GO:0048551 metalloenzyme inhibitor activity Stops, prevents or reduces the activity of metalloenzyme. A metalloenzyme is any enzyme that contains metal. MF
GO:0048552 regulation of metalloenzyme activity Any process that modulates the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal. BP
GO:0048553 negative regulation of metalloenzyme activity Any process that stops, prevents or reduces the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal. BP
GO:0048558 embryonic gut morphogenesis The process by which the anatomical structures of the gut are generated and organized during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. BP
GO:0048559 establishment of floral organ orientation The process that determines the orientation of the floral organs with reference to the central axis of the flower. BP
GO:0009818 defense response to protozoan, incompatible interaction A response of an organism to a protozoan that prevents the occurrence or spread of disease. BP
GO:0008050 female courtship behavior The actions or reactions of a female, for the purpose of attracting a sexual partner. BP
GO:0009816 defense response to bacterium, incompatible interaction A response of an organism to a bacterium that prevents the occurrence or spread of disease. BP
GO:0009817 defense response to fungus, incompatible interaction A response of an organism to a fungus that prevents the occurrence or spread of disease. BP
GO:0009814 defense response, incompatible interaction A response of an organism to a pathogenic agent that prevents the occurrence or spread of disease. BP
GO:0009815 1-aminocyclopropane-1-carboxylate oxidase activity Catalysis of the reaction: ascorbate + 1-aminocyclopropane-1-carboxylate + O2 = 2 H2O + ethene (ethylene) + L-dehydro-ascorbate + hydrocyanic acid + CO2. MF
GO:0009812 flavonoid metabolic process The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. BP
GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. BP
GO:0009810 stilbene metabolic process The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA. BP
GO:0009811 stilbene biosynthetic process The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. BP
GO:0043155 negative regulation of photosynthesis, light reaction Any process that stops, prevents or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis. BP
GO:0043154 negative regulation of caspase activity Any process that stops, prevents or reduces the frequency, rate or extent of caspase activity. BP
GO:0043157 response to cation stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. BP
GO:0043156 chromatin remodeling in response to cation stress Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. BP
GO:0043151 DNA synthesis during double-strand break repair via single-strand annealing The synthesis of DNA during the process of double-strand break repair via single-strand annealing. BP
GO:0043150 DNA synthesis during double-strand break repair via homologous recombination The synthesis of DNA during the process of double-strand break repair via homologous recombination. BP
GO:0043153 entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). BP
GO:0043152 induction of bacterial agglutination The processes by which infecting bacteria are clumped together by a host organism. BP
GO:0043159 acrosomal matrix A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction. CC
GO:0043158 heterocyst differentiation The process whereby a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen. BP
GO:0042400 ectoine catabolic process The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. BP
GO:0042401 biogenic amine biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. BP
GO:0042402 biogenic amine catabolic process The chemical reactions and pathways resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. BP
GO:0042403 thyroid hormone metabolic process The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. BP
GO:0042404 thyroid hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. BP
GO:0042405 nuclear inclusion body Intranuclear foci at which aggregated proteins have been sequestered. CC
GO:0042406 extrinsic to endoplasmic reticulum membrane Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region. CC
GO:0042407 cristae formation The assembly of cristae, the inwards folds of the inner mitochondrial membrane. BP
GO:0042408 myrcene/(E)-beta-ocimene synthase activity Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes. MF
GO:0042409 caffeoyl-CoA O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA. MF
GO:0005112 Notch binding Interacting selectively with the Notch (N) protein, a surface receptor. MF
GO:0009108 coenzyme biosynthetic process The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. BP
GO:0009109 coenzyme catabolic process The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. BP
GO:0050258 riboflavinase activity Catalysis of the reaction: riboflavin + H2O = ribitol + lumichrome. MF
GO:0050259 ribose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-ribose + NADP+ + H2O = D-ribonate + NADPH. MF
GO:0050256 ribitol-5-phosphate 2-dehydrogenase activity Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+. MF
GO:0050257 riboflavin phosphotransferase activity Catalysis of the reaction: D-glucose 1-phosphate + riboflavin = D-glucose + FMN. MF
GO:0050254 rhodopsin kinase activity Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. MF
GO:0050255 ribitol 2-dehydrogenase activity Catalysis of the reaction: ribitol + NAD+ = D-ribulose + NADH. MF
GO:0009100 glycoprotein metabolic process The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. BP
GO:0050253 retinyl-palmitate esterase activity Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate. MF
GO:0009102 biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. BP
GO:0050251 retinol isomerase activity Catalysis of the reaction: all-trans-retinol = 11-cis-retinol. MF
GO:0003887 DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template or primer. MF
GO:0003886 DNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. MF
GO:0003885 D-arabinono-1,4-lactone oxidase activity Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = D-erythro-ascorbate + H2O2. MF
GO:0003884 D-amino-acid oxidase activity Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2. MF
GO:0003883 CTP synthase activity Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. MF
GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. MF
GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. MF
GO:0003880 C-terminal protein carboxyl methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of the C-terminal residue of a protein. MF
GO:0003889 alpha DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). A DNA polymerase that functions during the priming of DNA replication. MF
GO:0047400 phosphonoacetate hydrolase activity Catalysis of the reaction: H2O + phosphonoacetate = phosphate + acetate. MF
GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]. MF
GO:0047406 beta-aspartyl-N-acetylglucosaminidase activity Catalysis of the reaction: H2O + 1-beta-aspartyl-N-acetyl-D-glucosaminylamine = L-asparagine + N-acetyl-D-glucosamine. MF
GO:0047404 glucuronosyl-disulfoglucosamine glucuronidase activity Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2-,6-disulfo-D-glucosamine. MF
GO:0032388 positive regulation of intracellular transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. BP
GO:0032389 MutLalpha complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. CC
GO:0018510 phloroglucinol reductase activity Catalysis of the reaction: dihydrophloroglucinol + NADP+ = phloroglucinol + NADPH + H+. MF
GO:0032384 negative regulation of intracellular cholesterol transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells. BP
GO:0032385 positive regulation of intracellular cholesterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells. BP
GO:0032386 regulation of intracellular transport Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. BP
GO:0032387 negative regulation of intracellular transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. BP
GO:0032380 regulation of intracellular sterol transport Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells. BP
GO:0018513 dibenzothiophene dihydrodiol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + NADH + H+. MF
GO:0032382 positive regulation of intracellular sterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells. BP
GO:0032383 regulation of intracellular cholesterol transport Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells. BP
GO:0018515 pimeloyl-CoA dehydrogenase activity Catalysis of the reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+. MF
GO:0052552 modulation by organism of immune response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. BP
GO:0018517 phthalate 4,5-cis-dihydrodiol dehydrogenase activity Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+. MF
GO:0018516 2,4-dichlorobenzoyl-CoA reductase activity Catalysis of the reaction: 4-chlorobenzoyl-CoA + NADP+ + HCl = 2,4-dichlorobenzoyl-CoA + NADPH + H+. MF
GO:0019350 teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. BP
GO:0019351 dethiobiotin biosynthetic process The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms. BP
GO:0019352 protoporphyrinogen IX biosynthetic process from glycine The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine. BP
GO:0019353 protoporphyrinogen IX biosynthetic process from glutamate The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate. BP
GO:0019354 siroheme biosynthetic process The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. BP
GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate. BP
GO:0019356 nicotinate nucleotide biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan. BP
GO:0019357 nicotinate nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid). BP
GO:0019358 nicotinate nucleotide salvage The generation of nicotinate nucleotide without de novo synthesis. BP
GO:0019359 nicotinamide nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. BP
GO:0032656 regulation of interleukin-13 production Any process that modulates the frequency, rate, or extent of interleukin-13 production. BP
GO:0032657 regulation of interleukin-14 production Any process that modulates the frequency, rate, or extent of interleukin-14 production. BP
GO:0032654 regulation of interleukin-11 production Any process that modulates the frequency, rate, or extent of interleukin-11 production. BP
GO:0032655 regulation of interleukin-12 production Any process that modulates the frequency, rate, or extent of interleukin-12 production. BP
GO:0032652 regulation of interleukin-1 production Any process that modulates the frequency, rate, or extent of interleukin-1 production. BP
GO:0032653 regulation of interleukin-10 production Any process that modulates the frequency, rate, or extent of interleukin-10 production. BP
GO:0032650 regulation of interleukin-1 alpha production Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production. BP
GO:0032651 regulation of interleukin-1 beta production Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. BP
GO:0032658 regulation of interleukin-15 production Any process that modulates the frequency, rate, or extent of interleukin-15 production. BP
GO:0032659 regulation of interleukin-16 production Any process that modulates the frequency, rate, or extent of interleukin-16 production. BP
GO:0048705 skeletal morphogenesis The process by which the anatomical structures of skeleton are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048704 embryonic skeletal morphogenesis The process by which the anatomical structures of skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0048707 larval or pupal morphogenesis (sensu Insecta) The process, occurring during larval or pupal development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048706 embryonic skeletal development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. BP
GO:0005131 growth hormone receptor binding Interacting selectively with the growth hormone receptor. MF
GO:0048700 acquisition of desiccation tolerance The process by which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state. BP
GO:0005133 interferon-gamma receptor binding Interacting selectively with the interferon-gamma receptor. MF
GO:0048702 embryonic neurocranium morphogenesis The process by which the anatomical structures of neurocranium are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The neurocranium is the portion of the vertebrate skull surrounding the brain. BP
GO:0048709 oligodendrocyte differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. BP
GO:0048708 astrocyte differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. BP
GO:0010298 dihydrocamalexic acid decarboxylase activity Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2. MF
GO:0010299 detoxification of cobalt ion The processes that reduce or remove the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion. BP
GO:0010296 prenylcysteine methylesterase activity Catalysis of the reaction: protein prenyl L-cysteine methylester + H2O = protein L-cysteine + methanol. MF
GO:0010297 heteroglycan binding Interacting selectively with heteroglycans. MF
GO:0010294 abscisic acid glucosyltransferase activity Catalysis of the reaction: ABA + UDP-D-glucose = ABA-glucose ester + UDP. MF
GO:0010295 (+)-abscisic acid 8'-hydroxylase activity Catalysis of the reaction: (+)-abscisate + NADPH + H+ + O2 = 8'-hydroxyabscisate + NADP+ + H2O. MF
GO:0010292 GTP:GDP antiporter activity Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out). MF
GO:0010293 abscisic aldehyde oxidase activity Catalysis of the reaction: abscisic aldehyde + H2O + O2 = abscisic acid + H2O2. MF
GO:0010290 chlorophyll catabolite transporter activity Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), into, out of, within or between cells. MF
GO:0010291 carotene beta-ring hydroxylase activity Catalysis of C3-hydroxylation reaction of the beta-ring of various carotenes. MF
GO:0006646 phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. BP
GO:0006647 phosphatidyl-N-monomethylethanolamine biosynthetic process The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. BP
GO:0006644 phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. BP
GO:0006642 triacylglycerol mobilization NA BP
GO:0006643 membrane lipid metabolic process The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. BP
GO:0006640 monoacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. BP
GO:0006641 triacylglycerol metabolic process The chemical reactions and pathways involving triacylglycerol, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins. BP
GO:0006648 dihydrosphingosine-1-P pathway NA BP
GO:0006649 phospholipid transfer to membrane The transfer of a phospholipid from its site of synthesis to the plasma membrane. BP
GO:0005599 collagen type X A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets. CC
GO:0005598 short-chain collagen Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens. CC
GO:0005593 FACIT collagen Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix. CC
GO:0005592 collagen type XI A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils. CC
GO:0005591 collagen type VIII A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets. CC
GO:0005590 collagen type VII A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. CC
GO:0005597 collagen type XVI A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils. CC
GO:0005596 collagen type XIV A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures. CC
GO:0005595 collagen type XII A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures. CC
GO:0005594 collagen type IX A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils. CC
GO:0018296 protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine. BP
GO:0018297 protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine. BP
GO:0018294 protein-FAD linkage via S-(8alpha-FAD)-L-cysteine The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine. BP
GO:0018295 protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine. BP
GO:0018292 molybdenum incorporation via L-cysteinyl molybdopterin The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin. BP
GO:0018293 protein-FAD linkage The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD). BP
GO:0018290 iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase. BP
GO:0018291 molybdenum incorporation into iron-sulfur cluster The incorporation of molybdenum into an iron-sulfur cluster. BP
GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. BP
GO:0018299 iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide. BP
GO:0000778 condensed nuclear chromosome kinetochore A multisubunit complex that is located at the pericentric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules. CC
GO:0000779 condensed chromosome, pericentric region The central region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. CC
GO:0000770 peptide pheromone export The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones. BP
GO:0000771 agglutination The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation. BP
GO:0000772 mating pheromone activity The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted. MF
GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine. MF
GO:0000774 adenyl-nucleotide exchange factor activity Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. MF
GO:0000775 chromosome, pericentric region The central region of a chromosome that includes the centromere and associated proteins. CC
GO:0000776 kinetochore A multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules. CC
GO:0000777 condensed chromosome kinetochore A multisubunit complex that is located at the pericentric region of a condensed chromosome and provides an attachment point for the spindle microtubules. CC
GO:0004648 phosphoserine transaminase activity Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. MF
GO:0004649 poly(ADP-ribose) glycohydrolase activity Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. MF
GO:0004640 phosphoribosylanthranilate isomerase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. MF
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity Catalysis of the reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. MF
GO:0004642 phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate. MF
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. MF
GO:0004644 phosphoribosylglycinamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. MF
GO:0004645 phosphorylase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. MF
GO:0004647 phosphoserine phosphatase activity Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate. MF
GO:0021832 cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration. BP
GO:0021833 cell-substrate adhesion involved in tangential migration using cell-cell interactions The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex. BP
GO:0021830 interneuron migration from the subpallium to the cortex The directed movement of interneurons from the subpallium to the cortex during forebrain development. BP
GO:0021831 embryonic olfactory bulb interneuron precursor migration The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb. BP
GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration. BP
GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration The signaling that results in the stimulation of cell movement in the rostral migratory stream. BP
GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron migration The creation and reception of signals that guide olfactory bulb interneurons down concentration gradients towards the olfactory bulb. BP
GO:0021835 chemoattraction involved in embryonic olfactory bulb interneuron migration The creation and reception of signals that result in the migration of interneurons up a concentration gradient towards the olfactory bulb. BP
GO:0021838 motogenic signaling involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex. BP
GO:0021839 interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex The process whereby migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex. BP
GO:0007209 tachykinin receptor, phospholipase C activating pathway The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate. BP
GO:0007208 serotonin receptor, phospholipase C activating pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate. BP
GO:0051217 molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). BP
GO:0051216 cartilage development The process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. BP
GO:0051211 anisotropic cell growth The process by which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell. BP
GO:0051210 isotropic cell growth The process by which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth. BP
GO:0051213 dioxygenase activity Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate. MF
GO:0051212 vanadium ion binding Interacting selectively with vanadium (V) ions. MF
GO:0015523 arabinose efflux permease activity Catalysis of the reaction: H+(out) + arabinose(in) = H+(in) + arabinose(out). MF
GO:0007200 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate. BP
GO:0007202 phospholipase C activation The series of molecular signals that results in the upregulation of phospholipase C activity in response to the signal. BP
GO:0015527 glycerol-phosphate:inorganic phosphate antiporter activity Catalysis of the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out). MF
GO:0015526 hexose-phosphate:inorganic phosphate antiporter activity Catalysis of the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out). MF
GO:0007207 muscarinic acetylcholine receptor, phospholipase C activating pathway The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate. BP
GO:0007206 metabotropic glutamate receptor, phospholipase C activating pathway The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate. BP
GO:0018128 peptidyl-serine cyclase activity NA MF
GO:0018129 peptidyl-oxazoline dehydrogenase activity NA MF
GO:0001698 gastrin-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of gastrin with its receptor. BP
GO:0001699 acetylcholine-induced gastric acid secretion The regulated release of gastric acid by parietal cells in response to acetylcholine. BP
GO:0018120 peptidyl-arginine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine. BP
GO:0018121 NAD(P)-asparagine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine. MF
GO:0018122 peptidyl-asparagine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine. BP
GO:0018123 peptidyl-cysteine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine. BP
GO:0018124 peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue. BP
GO:0018125 peptidyl-cysteine methylation The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine. BP
GO:0018126 protein amino acid hydroxylation The addition of a hydroxy group to a protein amino acid. BP
GO:0018127 NAD(P)-serine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine. MF
GO:0021784 postganglionic parasympathetic nervous system development The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. BP
GO:0021785 branchiomotor neuron axon guidance The process by which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021786 branchiomotor neuron axon guidance in the neural tube The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021787 chemorepulsion of branchiomotor neuron axon in neural tube The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021780 glial cell fate specification The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. BP
GO:0021781 glial cell fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glial cell. BP
GO:0021782 glial cell development The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0021783 preganglionic parasympathetic nervous system development The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. BP
GO:0019651 citrate catabolic process to diacetyl The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP. BP
GO:0019650 glucose catabolic process to butanediol The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into 2,3-butanediol and other substances; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia. BP
GO:0019653 anaerobic purine catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of purines, yielding energy in the form of ATP. BP
GO:0019652 lactate fermentation to propionate and acetate The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP). BP
GO:0021788 chemoattraction of branchiomotor neuron axon in neural tube The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021789 branchiomotor neuron axon guidance in the branchial arch mesenchyme The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0019657 pyruvate fermentation to propionate The anaerobic conversion of pyruvate to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate. BP
GO:0019656 glucose catabolic process to D-lactate and ethanol The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule. BP
GO:0001966 thigmotaxis The directed movement of a motile cell or organism in response to touch. BP
GO:0001967 suckling behavior Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast. BP
GO:0001964 startle response An action or movement due to the application of a sudden unexpected stimulus. BP
GO:0001965 G-protein alpha-subunit binding Interacting selectively with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. MF
GO:0001962 alpha-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,3-linkage. MF
GO:0001963 synaptic transmission, dopaminergic The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. BP
GO:0001960 negative regulation of cytokine and chemokine mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the cytokine and chemokine mediated signaling pathway. BP
GO:0001961 positive regulation of cytokine and chemokine mediated signaling pathway Any process that activates or increases the frequency, rate or extent of a cytokine and chemokine mediated signaling pathway. BP
GO:0001968 fibronectin binding Interacting selectively with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. MF
GO:0001969 regulation of activation of membrane attack complex Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. BP
GO:0030467 establishment and/or maintenance of cell polarity (sensu Fungi) The specification or maintenance of polarized cell growth patterns. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0030466 chromatin silencing at silent mating-type cassette Repression of transcription at silent mating-type loci by the formation of heterochromatin. BP
GO:0030469 maintenance of cell polarity (sensu Fungi) The maintenance of established polarized cell growth patterns. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0030468 establishment of cell polarity (sensu Fungi) The specification of polarized cell growth patterns. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0017033 DNA topoisomerase I binding Interacting selectively with the enzyme DNA topoisomerase I. MF
GO:0017032 potassium:amino acid symporter activity Catalysis of the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in). MF
GO:0017034 Rap guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0017039 dipeptidyl-peptidase III activity Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides. MF
GO:0017038 protein import The directed movement of proteins into a cell or organelle. BP
GO:0031734 CCR9 chemokine receptor binding Interacting selectively with a CCR9 chemokine receptor. MF
GO:0031735 CCR10 chemokine receptor binding Interacting selectively with a CCR10 chemokine receptor. MF
GO:0031736 CCR11 chemokine receptor binding Interacting selectively with a CCR11 chemokine receptor. MF
GO:0031737 CX3C chemokine receptor binding Interacting selectively with a CX3C chemokine receptor. MF
GO:0031730 CCR5 chemokine receptor binding Interacting selectively with a CCR5 chemokine receptor. MF
GO:0031731 CCR6 chemokine receptor binding Interacting selectively with a CCR6 chemokine receptor. MF
GO:0031732 CCR7 chemokine receptor binding Interacting selectively with a CCR7 chemokine receptor. MF
GO:0031733 CCR8 chemokine receptor binding Interacting selectively with a CCR8 chemokine receptor. MF
GO:0031738 XCR1 chemokine receptor binding Interacting selectively with a XCR1 chemokine receptor. MF
GO:0031739 cholecystokinin receptor binding Interacting selectively with a cholecystokinin receptor. MF
GO:0015893 drug transport The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of, within or between cells. BP
GO:0015892 siderophore-iron transport The directed movement of iron-siderophores into, out of, within or between cells. BP
GO:0015891 siderophore transport The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of, within or between cells. BP
GO:0015890 nicotinamide mononucleotide transport The directed movement of nicotinamide mononucleotide into, out of, within or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP. BP
GO:0015897 organomercurial transport The directed movement of organomercurial compounds into, out of, within or between cells. Organomercurial substances are any organic compound containing a mercury atom. BP
GO:0015896 nalidixic acid transport The directed movement of nalidixic acid into, out of, within or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. BP
GO:0015895 alkane transport The directed movement of alkanes into, out of, within or between cells. Alkanes are saturated aliphatic hydrocarbon compounds. BP
GO:0015894 acriflavine transport The directed movement of acriflavine into, out of, within or between cells. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. BP
GO:0015899 aminotriazole transport The directed movement of aminotriazole into, out of, within or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity. BP
GO:0015898 amiloride transport The directed movement amiloride into, out of, within or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. BP
GO:0004262 cerevisin activity Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides. MF
GO:0004263 chymotrypsin activity Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa. MF
GO:0051010 microtubule plus-end binding Interacting selectively with the plus end of a microtubule. MF
GO:0009342 glutamate synthase complex (NADPH) A complex that possesses glutamate synthase (NADPH) activity. CC
GO:0009343 biotin carboxylase complex An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2). CC
GO:0009340 DNA topoisomerase IV complex A heterodimeric enzyme, which in most bacterial species is composed of two subunits, PARC and PARE. Functions in chromosome segregation and can relax supercoiled DNA. CC
GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is an heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. CC
GO:0009346 citrate lyase complex Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. CC
GO:0009347 aspartate carbamoyltransferase complex A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides. CC
GO:0009344 nitrite reductase complex [NAD(P)H] Complex that possesses nitrite reductase [NAD(P)H] activity. CC
GO:0009345 glycine-tRNA ligase complex A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly). CC
GO:0009348 ornithine carbamoyltransferase complex An enzyme complex that catalyzes the transfer of a carbamoyl to ornithine, forming citrulline. CC
GO:0009349 riboflavin synthase complex An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine. CC
GO:0044259 organismal macromolecule metabolic process The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. BP
GO:0044258 intestinal lipid catabolic process The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. BP
GO:0009694 jasmonic acid metabolic process The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid. BP
GO:0009695 jasmonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative. BP
GO:0009696 salicylic acid metabolic process The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. BP
GO:0009697 salicylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid. BP
GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. BP
GO:0009691 cytokinin biosynthetic process The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. BP
GO:0009692 ethylene metabolic process The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. BP
GO:0009693 ethylene biosynthetic process The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. BP
GO:0009698 phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. BP
GO:0009699 phenylpropanoid biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid. BP
GO:0015066 alpha-amylase inhibitor activity Stops, prevents or reduces the activity of alpha-amylase. MF
GO:0044254 organismal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level. BP
GO:0015067 amidinotransferase activity Catalysis of the reversible transfer of an amidino group to an acceptor. MF
GO:0009643 photosynthetic acclimation NA BP
GO:0010176 homogentisate phytyltransferase activity Catalysis of the reaction: homogentisic acid + phytyl diphosphate -> 2-methyl-6-phytylplastoquinol. MF
GO:0015065 uridine nucleotide receptor activity Combining with UTP or UDP to initiate a change in cell activity. MF
GO:0044251 protein catabolic process by pepsin The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid). BP
GO:0010174 nucleoside transporter activity, against a concentration gradient Enables the directed movement of a nucleoside across cell membranes against a concentration gradient. MF
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. MF
GO:0016819 hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-. MF
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. MF
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. MF
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. MF
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. MF
GO:0009798 axis specification The establishment, maintenance and elaboration of a pattern along a line or a point. BP
GO:0016817 hydrolase activity, acting on acid anhydrides Catalysis of the hydrolysis of any acid anhydride. MF
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. MF
GO:0016815 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. MF
GO:0032414 positive regulation of ion transporter activity Any process that activates or increases the activity of an ion transporter. BP
GO:0032415 regulation of sodium:hydrogen antiporter activity Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). BP
GO:0032416 negative regulation of sodium:hydrogen antiporter activity Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). BP
GO:0032417 positive regulation of sodium:hydrogen antiporter activity Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). BP
GO:0032410 negative regulation of transporter activity Any process that stops or reduces the activity of a transporter. BP
GO:0032411 positive regulation of transporter activity Any process that activates or increases the activity of a transporter. BP
GO:0032412 regulation of ion transporter activity Any process that modulates the activity of an ion transporter. BP
GO:0032413 negative regulation of ion transporter activity Any process that stops or reduces the activity of an ion transporter. BP
GO:0032418 lysosome localization The processes by which a lysosome is transported to, and/or maintained in, a specific location. BP
GO:0032419 extrinsic to lysosome membrane Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region. CC
GO:0008565 protein transporter activity Enables the directed movement of proteins into, out of, within or between cells. MF
GO:0008564 protein-exporting ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the concomitant secretion of proteins. MF
GO:0008566 mitochondrial protein-transporting ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex. MF
GO:0008560 steroid-transporting ATPase activity Catalysis of the reaction: ATP + H2O + steroid(in) = ADP + phosphate + steroid(out). MF
GO:0008569 minus-end-directed microtubule motor activity Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP). MF
GO:0008568 microtubule-severing ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. MF
GO:0047252 beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity Catalysis of the reaction: 1,6-alpha-D-mannosyloligodaccharide + beta-D-mannosylphosphodecaprenol = 1,6-alpha-D-mannosyl-1,6-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate. MF
GO:0047253 alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP. MF
GO:0047250 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity Catalysis of the reaction: p-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + UDP. MF
GO:0047251 thiohydroximate beta-D-glucosyltransferase activity Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP. MF
GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. MF
GO:0047257 diglucosyl diacylglycerol synthase activity Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)sn-glycerol. MF
GO:0047254 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP. MF
GO:0047255 galactogen 6-beta-galactosyltransferase activity Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP. MF
GO:0047258 sphingosine beta-galactosyltransferase activity Catalysis of the reaction: sphingosine + UDP-galactose = psychosine + UDP. MF
GO:0047259 glucomannan 4-beta-mannosyltransferase activity Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP. MF
GO:0030818 negative regulation of cAMP biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030819 positive regulation of cAMP biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030816 positive regulation of cAMP metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030817 regulation of cAMP biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030814 regulation of cAMP metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030815 negative regulation of cAMP metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0030812 negative regulation of nucleotide catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. BP
GO:0030813 positive regulation of nucleotide catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. BP
GO:0030810 positive regulation of nucleotide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. BP
GO:0030811 regulation of nucleotide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. BP
GO:0050878 regulation of body fluids Any process that modulates the levels of body fluids. BP
GO:0050879 organismal movement Physiological processes involved in the relocation of an organism or an anatomical part of an organism. BP
GO:0050877 neurological process The processes pertaining to the functions of the nervous system of an organism. BP
GO:0050872 white fat cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. BP
GO:0050873 brown fat cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. BP
GO:0050870 positive regulation of T cell activation Any process that activates or increases the frequency, rate or extent of T cell activation. BP
GO:0050871 positive regulation of B cell activation Any process that activates or increases the frequency, rate or extent of B cell activation. BP
GO:0035288 anterior head segmentation Partitioning the head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments. BP
GO:0035289 posterior head segmentation Partitioning the posterior region of the head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains. BP
GO:0046611 lysosomal hydrogen-translocating V-type ATPase complex NA CC
GO:0046610 lysosomal hydrogen ion transporting ATPase V0 domain NA CC
GO:0046612 lysosomal hydrogen ion transporting ATPase V1 domain NA CC
GO:0035280 miRNA-mediated gene silencing, miRNA loading onto RISC The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC). BP
GO:0035281 pre-microRNA export from nucleus Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product. BP
GO:0035282 segmentation The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. BP
GO:0035283 central nervous system segmentation Division of the central nervous system into a series of semi-repetitive parts or segments. BP
GO:0035284 brain segmentation Division of the brain into a series of semi-repetitive parts or segments. BP
GO:0035285 appendage segmentation Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented. BP
GO:0035286 leg segmentation Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint. BP
GO:0035287 head segmentation Partitioning the head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial). BP
GO:0045294 alpha-catenin binding Interacting selectively with the alpha subunit of the catenin complex. MF
GO:0030108 HLA-A specific activating MHC class I receptor activity Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. MF
GO:0030109 HLA-B specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. MF
GO:0030104 water homeostasis Any of the processes involved in the maintenance of an internal equilibrium of water within an organism or cell. BP
GO:0030107 HLA-A specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. MF
GO:0030100 regulation of endocytosis Any process that modulates the frequency, rate or extent of endocytosis. BP
GO:0030101 natural killer cell activation The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0030103 vasopressin secretion The regulated release of vasopressin from secretory granules into the blood. BP
GO:0004408 holocytochrome-c synthase activity Catalysis of the reaction: holocytochrome c = apocytochrome c + heme. MF
GO:0004409 homoaconitate hydratase activity Catalysis of the reaction: 2-hydroxybutane-1,2,4-tricarboxylate = but-1-ene-1,2,4-tricarboxylate + H2O. MF
GO:0004406 H3/H4 histone acetyltransferase activity Catalysis of the addition of an acetyl group to a histone, specific for histones H3 and H4. MF
GO:0004407 histone deacetylase activity Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. MF
GO:0004405 H2A/H2B histone acetyltransferase activity Catalysis of the addition of an acetyl group to a histone, specific for histones H2A and H2B. MF
GO:0004402 histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. MF
GO:0004400 histidinol-phosphate transaminase activity Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. MF
GO:0004401 histidinol-phosphatase activity Catalysis of the reaction: L-histidinol-phosphate + H2O = L-histidinol + phosphate. MF
GO:0006930 substrate-bound cell migration, cell extension The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. BP
GO:0006931 substrate-bound cell migration, cell attachment to substrate The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions. BP
GO:0006932 substrate-bound cell migration, cell contraction The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves. BP
GO:0006933 substrate-bound cell migration, cell release from substrate The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. BP
GO:0006934 substrate-bound cell migration, adhesion receptor recycling The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions. BP
GO:0008959 phosphate acetyltransferase activity Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate. MF
GO:0048079 regulation of cuticle pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. BP
GO:0006937 regulation of muscle contraction Any process that modulates the frequency, rate or extent of muscle contraction. BP
GO:0048077 negative regulation of eye pigmentation (sensu Endopterygota) Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0008955 peptidoglycan glycosyltransferase activity Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. MF
GO:0048075 positive regulation of eye pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. BP
GO:0048074 negative regulation of eye pigmentation Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. BP
GO:0048073 regulation of eye pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism. BP
GO:0048072 eye pigmentation (sensu Endopterygota) Establishment of a pattern of pigment in the eye. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048071 sex-specific pigmentation Establishment of a pattern of pigment in one sex that is not observed in the other sex. BP
GO:0048070 regulation of developmental pigmentation Any process that modulates the frequency, rate or extent of the deposition of coloring matter occurring during development. BP
GO:0042611 MHC protein complex A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. CC
GO:0042610 CD8 receptor binding Interacting selectively with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. MF
GO:0042613 MHC class II protein complex A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. CC
GO:0042612 MHC class I protein complex A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. CC
GO:0042615 CD154 receptor binding Interacting selectively with CD154, a receptor found on the surface of some activated lymphocytes. MF
GO:0042614 CD70 receptor binding Interacting selectively with a CD70, a receptor found on the surface of most activated B cells and some activated T cells. MF
GO:0042617 paclitaxel biosynthetic process The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment. BP
GO:0042616 paclitaxel metabolic process The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment. BP
GO:0042619 poly-hydroxybutyrate biosynthetic process The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells. BP
GO:0042618 poly-hydroxybutyrate metabolic process The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells. BP
GO:0050595 7-deoxyloganin 7-hydroxylase activity Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O. MF
GO:0050594 tabersonine 16-hydroxylase activity Catalysis of the reaction: tabersonine + NADPH + H+ + O2 = 16-hydroxytabersonine + NADP+ + H2O. MF
GO:0050597 taxane 10-beta-hydroxylase activity Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-yl acetate = H2O + NADP+ + 10-beta-hydroxytaxa-4(20),11-dien-5-alpha-yl acetate. MF
GO:0050596 vinorine hydroxylase activity Catalysis of the reaction: vinorine + NADPH + H+ + O2 = vomilenine + NADP+ + H2O. MF
GO:0050591 quinine 3-monooxygenase activity Catalysis of the reaction: quinine + NADPH + H+ + O2 = 3-hydroxyquinine + NADP+ + H2O. MF
GO:0050590 desacetoxyvindoline 4-hydroxylase activity Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2. MF
GO:0018728 succinyl-CoA:benzylsuccinate CoA-transferase activity NA MF
GO:0050592 4-hydroxyphenylacetaldehyde oxime monooxygenase activity Catalysis of the reaction: 4-hydroxyphenylacetaldehyde oxime + NADPH + H+ + O2 = 4-hydroxymandelonitrile + NADP+ + 2 H2O. MF
GO:0018726 9-phenanthrol sulfotransferase activity Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate. MF
GO:0018727 2-phenanthrol sulfotransferase activity Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate. MF
GO:0018724 4-phenanthrol sulfotransferase activity Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate. MF
GO:0018725 trans-3,4-dihydrodiolphenanthrene sulfotransferase activity Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate. MF
GO:0018722 1-phenanthrol sulfotransferase activity Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate. MF
GO:0018723 3-phenanthrol sulfotransferase activity Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate. MF
GO:0018720 phenol kinase activity Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate. MF
GO:0018721 trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate. MF
GO:0019099 female germ-line sex determination The determination of sex and sexual phenotype in a female organism's germ line. BP
GO:0019098 reproductive behavior The specific actions or reactions of an organism that are associated with reproduction. BP
GO:0019097 pole plasm mitochondrial srRNA localization The processes by which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0019096 pole plasm mitochondrial lrRNA localization The processes by which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0019095 pole plasm mitochondrial rRNA localization The processes by which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0019094 pole plasm mRNA localization The processes by which mRNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0019093 mitochondrial RNA localization The processes by which mitochondrial RNA is transported to, or maintained in, a specific location. BP
GO:0019092 mitochondrial srRNA export from mitochondrion The directed movement of mitochondrial srRNA out of a mitochondrion. BP
GO:0019091 mitochondrial lrRNA export from mitochondrion The directed movement of mitochondrial lrRNA out of a mitochondrion. BP
GO:0019090 mitochondrial rRNA export from mitochondrion The directed movement of mitochondrial rRNA out of a mitochondrion. BP
GO:0050049 leucine dehydrogenase activity Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH. MF
GO:0050048 leucine transaminase activity Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. MF
GO:0050047 leucine 2,3-aminomutase activity Catalysis of the reaction: (2S)-alpha-leucine = (3R)-beta-leucine. MF
GO:0050046 lathosterol oxidase activity Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2. MF
GO:0050045 laminaribiose phosphorylase activity Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate. MF
GO:0050044 galactose-6-phosphate isomerase activity Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate. MF
GO:0050043 lactate racemase activity Catalysis of the reaction: (S)-lactate = (R)-lactate. MF
GO:0050042 lactate-malate transhydrogenase activity Catalysis of the reaction: (S)-lactate + oxaloacetate = pyruvate + malate. MF
GO:0050041 lactate aldolase activity Catalysis of the reaction: (S)-lactate = formate + acetaldehyde. MF
GO:0050040 lactate 2-monooxygenase activity Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O. MF
GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter. BP
GO:0007323 peptide pheromone maturation The generation of a mature, active peptide pheromone via processes unique to its processing and modification. BP
GO:0007320 insemination The introduction of semen or sperm into the genital tract of a female. BP
GO:0007321 sperm displacement The physical displacement of sperm stored from previous mating encounters. BP
GO:0006907 pinocytosis The process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. BP
GO:0006906 vesicle fusion Fusion of the membrane of a transport vesicle with its target membrane. BP
GO:0006900 membrane budding The evagination of a membrane, resulting in formation of a vesicle. BP
GO:0052359 catabolism by organism of glucan in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052358 catabolism by host of symbiont glucan The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052355 catabolism by host of symbiont cell wall cellulose The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052354 catabolism by organism of carbohydrate in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052357 catabolism by host of symbiont cell wall pectin The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052356 catabolism by host of symbiont cell wall chitin The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052353 catabolism by host of symbiont carbohydrate The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052352 biosynthesis by host of substance in symbiont The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0001306 age-dependent response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism. BP
GO:0001307 extrachromosomal circular DNA accumulation during replicative cell aging Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. BP
GO:0001304 progressive alteration of chromatin during replicative cell aging The process that occurs in dividing cells as they age that results in changes to chromatin structure. BP
GO:0001305 progressive alteration of chromatin during chronological cell aging The process that occurs in non-dividing cells as they age that results in changes to chromatin structure. BP
GO:0001302 replicative cell aging The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division. BP
GO:0001303 nucleolar fragmentation during replicative aging Process of enlargement and fragmentation of the nucleolus into multiple rounded structures that occurs in conjunction with increasing age in dividing cells. BP
GO:0001300 chronological cell aging The process associated with progression of the cell from its inception to the end of its lifespan that occur when the cell is in a non-dividing, or quiescent, state. BP
GO:0001301 progressive alteration of chromatin during cell aging The process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. BP
GO:0001308 loss of chromatin silencing during replicative cell aging The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins. BP
GO:0001309 age-dependent telomere shortening Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process. BP
GO:0005416 cation:amino acid symporter activity Catalysis of the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). MF
GO:0005415 nucleoside:sodium symporter activity Catalysis of the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). MF
GO:0005412 glucose:sodium symporter activity Catalysis of the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). MF
GO:0015286 innexin channel activity NA MF
GO:0015284 fructose uniporter activity Catalysis of the reaction: fructose(out) = fructose(in). MF
GO:0015285 connexon channel activity NA MF
GO:0015282 NADPH oxidase-associated cytochrome b558 hydrogen channel activity NA MF
GO:0015283 apoptogenic cytochrome c release channel activity NA MF
GO:0015280 amiloride-sensitive sodium channel activity NA MF
GO:0015281 nonselective cation channel activity NA MF
GO:0015288 porin activity Allows the energy independent passage of small (less than 1000 Da) solutes across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. MF
GO:0016959 class I ribonucleotide reductase activity NA MF
GO:0016951 nickel-iron-selenium hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. The nickel-(iron-sulfur)-selenium-containing hydrogenases ((NiFe-Se) hydrogenases) which contain nickel and selenium in equimolecular amounts plus (4Fe-4S) centers. MF
GO:0016950 nickel-iron hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. Nickel-(iron-sulfur)-containing hydrogenases ((NiFe) hydrogenases) possess two (4Fe-4S) centers and one (3Fe-xS) cluster in addition to nickel. The redox active nickel is ligated by at least two cysteinyl thiolate residues and the (NiFe) hydrogenases are particularly resistant to inhibitors such as CO and nitrite (NO2(-)). MF
GO:0016954 nickel superoxide dismutase activity Catalysis of the reaction: 2 peroxide radical + 2 H+ = O2 + H2O2. MF
GO:0016488 farnesol catabolic process The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. BP
GO:0016485 protein processing The post translational modification of a protein, particularly secretory proteins and proteins targeted for membranes or specific cellular locations. BP
GO:0016484 proprotein convertase 2 activator activity Required for the maturation and activation of proprotein convertase 2. MF
GO:0016487 farnesol metabolic process The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. BP
GO:0016486 peptide hormone processing The generation of a mature peptide hormone by posttranslational processing of a prohormone. BP
GO:0016481 negative regulation of transcription Any process that stops, prevents or reduces the frequency, rate or extent of transcription. BP
GO:0016480 negative regulation of transcription from RNA polymerase III promoter Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter. BP
GO:0016483 tryptophan hydroxylase activator activity Increases the activity of the enzyme tryptophase hydroxylase. MF
GO:0016482 cytoplasmic transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell. BP
GO:0021663 rhombomere 4 formation The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021662 rhombomere 4 structural organization The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021661 rhombomere 4 morphogenesis The process by which the anatomical structure of rhombomere 4 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021660 rhombomere 3 formation The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021667 rhombomere 6 morphogenesis The process by which the anatomical structure of rhombomere 6 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021666 rhombomere 5 formation The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021665 rhombomere 5 structural organization The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021664 rhombomere 5 morphogenesis The process by which the anatomical structures of rhombomere 5 are generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021669 rhombomere 6 formation The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021668 rhombomere 6 structural organization The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0015758 glucose transport The directed movement of the hexose monosaccharide glucose into, out of, within or between cells. BP
GO:0015759 beta-glucoside transport The directed movement of beta-glucosides into, out of, within or between cells. Beta-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. BP
GO:0015750 pentose transport The directed movement of pentoses into, out of, within or between cells. A pentose is any aldose with a chain of five carbon atoms in the molecule. BP
GO:0015751 arabinose transport The directed movement of arabinose, a pentose monosaccharide that occurs in both D and L configurations, into, out of, within or between cells. BP
GO:0015752 D-ribose transport The directed movement of D-ribose into, out of, within or between cells. As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. BP
GO:0015753 D-xylose transport The directed movement of D-xylose into, out of, within or between cells. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. BP
GO:0015754 allose transport The directed movement of allose into, out of, within or between cells. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. BP
GO:0015755 fructose transport The directed movement of fructose into, out of, within or between cells. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. BP
GO:0015756 fucose transport The directed movement of fucose into, out of, within or between cells. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. BP
GO:0015757 galactose transport The directed movement of galactose into, out of, within or between cells. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. BP
GO:0016229 steroid dehydrogenase activity NA MF
GO:0046059 dAMP catabolic process The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). BP
GO:0046058 cAMP metabolic process The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0046053 dAMP metabolic process The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). BP
GO:0046052 UTP catabolic process The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate. BP
GO:0046051 UTP metabolic process The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. BP
GO:0046050 UMP catabolic process The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate. BP
GO:0046057 dADP catabolic process The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). BP
GO:0046056 dADP metabolic process The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). BP
GO:0046055 dGMP catabolic process The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). BP
GO:0046054 dGMP metabolic process The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). BP
GO:0030342 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity Catalysis of the hydroxylation of C-1 of 25-hydroxycalciferol (25-hydroxyvitamin D3) to form 1-alpha,25-dihydroxycalciferol. MF
GO:0030343 vitamin D3 25-hydroxylase activity Catalysis of the hydroxylation of C-25 of calciferol (vitamin D3) to form 25-hydroxycalciferol. MF
GO:0030340 hyaluronate lyase activity Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. MF
GO:0030341 chondroitin AC lyase activity Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. MF
GO:0030346 protein phosphatase 2B binding Interacting selectively with the enzyme protein phosphatase 2B. MF
GO:0030347 syntaxin-2 binding Interacting selectively with the SNAP receptor syntaxin-2. MF
GO:0030345 structural constituent of tooth enamel The action of a molecule that contributes to the structural integrity of tooth enamel. MF
GO:0030348 syntaxin-3 binding Interacting selectively with the SNAP receptor syntaxin-3. MF
GO:0030349 syntaxin-13 binding Interacting selectively with the SNAP receptor syntaxin-13. MF
GO:0030694 flagellar basal body, rod (sensu Bacteria) The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0030695 GTPase regulator activity Modulates the rate of GTP hydrolysis by a GTPase. MF
GO:0030696 tRNA (m5U54) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule. MF
GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the C5 atom of the uridine residue at position 54 in a tRNA molecule. MF
GO:0030690 Noc1p-Noc2p complex A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis. CC
GO:0030691 Noc2p-Noc3p complex A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis. CC
GO:0030692 Noc4p-Nop14p complex A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis. CC
GO:0030693 caspase activity Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue. MF
GO:0030698 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. MF
GO:0030699 glycine reductase activity Catalysis of the reaction: acetyl phosphate + ammonia + thioredoxin disulfide = glycine + phosphate + thioredoxin. MF
GO:0015310 benomyl:hydrogen antiporter activity Catalysis of the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out). MF
GO:0047861 diiodotyrosine transaminase activity Catalysis of the reaction: 3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate. MF
GO:0047860 diiodophenylpyruvate reductase activity Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH. MF
GO:0047863 dimethylallylcistransferase activity Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate. MF
GO:0047862 diisopropyl-fluorophosphatase activity Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride. MF
GO:0047865 dimethylglycine dehydrogenase activity Catalysis of the reaction: N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor. MF
GO:0047864 dimethylaniline-N-oxide aldolase activity Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde. MF
GO:0047867 dimethylmalate dehydrogenase activity Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH. MF
GO:0047866 dimethylglycine oxidase activity Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2. MF
GO:0047869 dimethylpropiothetin dethiomethylase activity Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate. MF
GO:0047868 dimethylmaleate hydratase activity Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O. MF
GO:0015311 monoamine:hydrogen antiporter activity Catalysis of the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out). MF
GO:0015312 polyamine:hydrogen antiporter activity Catalysis of the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out). MF
GO:0031565 cytokinesis checkpoint A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum. BP
GO:0042677 cone cell fate determination (sensu Endopterygota) Process by which a cell becomes capable of differentiating autonomously into a cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0031567 cell size control checkpoint Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size. BP
GO:0031566 cytokinesis, contractile ring maintenance The cell cycle process whereby the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. BP
GO:0031561 bud tip polarisome Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud. CC
GO:0031560 bud neck polarisome Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis. CC
GO:0031563 mating projection tip polarisome Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone. CC
GO:0031562 hyphal tip polarisome Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha. CC
GO:0031569 G2/M transition size control checkpoint A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until cells have reached a critical size. BP
GO:0042675 cone cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a cone cell, a cone-shaped cell, sensitive to light and found in the eye. BP
GO:0042674 cone cell differentiation (sensu Endopterygota) The process whereby a relatively unspecialized cell acquires the specialized features of a cone cell. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0015313 fluconazole:hydrogen antiporter activity Catalysis of the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out). MF
GO:0042673 regulation of retinal cone cell fate specification Any process that mediates the specification of a cell into a retinal cone cell. BP
GO:0042672 retinal cone cell fate specification Process by which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0042671 retinal cone cell fate determination Process by which a cell becomes capable of differentiating autonomously into an retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0042670 retinal cone cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a retinal cone cell. BP
GO:0015314 aminotriazole:hydrogen antiporter activity Catalysis of the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out). MF
GO:0009553 female gametophyte development The process whose specific outcome is the progression of the female gametophyte over time, from its formation to the mature structure. The female gametophyte (embryo sac) develops from the haploid megaspores. BP
GO:0009552 gamete generation (sensu Magnoliophyta) The generation, maintenance, and proliferation of gametes, as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009551 secondary plasmodesma NA CC
GO:0009550 primary plasmodesma NA CC
GO:0009557 antipodal cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an antipodal cell. BP
GO:0009556 microsporogenesis The formation and development of haploid microspores from diploid sporogenous cells. Microspores are any of the spores in heterosporous plants that give rise to male gametophytes and are generally smaller than the megaspore. BP
GO:0009555 male gametophyte development The process whose specific outcome is the progression of the male gametophyte over time, from its formation to the mature structure. This begins with the haploid microspores and ends with the mature microgametophytes containing the gametes (pollen). BP
GO:0009554 megasporogenesis The formation and development of haploid megaspores from the megaspore mother cell. Megaspores are any of the spores in heterosporous plants that give rise to female gametophytes and are generally larger than the microspore. BP
GO:0009559 female gametophyte central cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an endosperm mother cell. This is a bi-nucleate cell containing the two nuclei that were the polar nuclei. BP
GO:0009558 cellularization of megagametophyte The process by which the seven-nucleate single celled female gametophyte develops into the seven celled female gametophyte. The seven cells are the egg cell, two synergid cells, one endosperm mother cell that has two polar nuclei, and three antipodal cells. BP
GO:0015315 organophosphate:inorganic phosphate antiporter activity Catalysis of the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out). MF
GO:0046808 assemblon Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously. CC
GO:0046809 replication compartment Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously. CC
GO:0046800 enhancement of virulence Any process that activates or increases the severity of viral infection and subsequent disease. BP
GO:0046801 intracellular transport of viral capsid in host cell The directed movement of viral capsid proteins within the host cell. BP
GO:0046802 egress of viral procapsid from host cell nucleus The exit of the immature viral procapsid from the nucleus of the host cell. BP
GO:0046803 reduction of virulence Any process that stops, prevents or reduces the severity of viral infection and subsequent disease. BP
GO:0046804 peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine. BP
GO:0046805 protein-heme linkage via 1'-L-histidine The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine). BP
GO:0046806 viral scaffold A complex of proteins that form a scaffold around which the viral capsid is constructed. CC
GO:0046807 viral scaffold assembly and maintenance The assembly and maintenance of the viral scaffold around which the viral capsid is constructed. BP
GO:0045579 positive regulation of B cell differentiation Any process that activates or increases the frequency, rate or extent of B cell differentiation. BP
GO:0045578 negative regulation of B cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of B cell differentiation. BP
GO:0045571 negative regulation of imaginal disc growth Any process that stops, prevents or reduces the frequency, rate or extent of imaginal disc growth. BP
GO:0045570 regulation of imaginal disc growth Any process that modulates the frequency, rate or extent of the growth of the imaginal disc. BP
GO:0045572 positive regulation of imaginal disc growth Any process that activates or increases the frequency, rate or extent of imaginal disc growth. BP
GO:0045575 basophil activation The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors. BP
GO:0045574 sterigmatocystin catabolic process The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. BP
GO:0045577 regulation of B cell differentiation Any process that modulates the frequency, rate or extent of B cell differentiation. BP
GO:0045576 mast cell activation The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. BP
GO:0042031 angiotensin-converting enzyme inhibitor activity Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I. MF
GO:0042030 ATPase inhibitor activity Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate. MF
GO:0042033 chemokine biosynthetic process The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. BP
GO:0047040 pteridine reductase activity Catalysis of the reaction: 2 NADP+ + tetra-hydro-biopterin = 2 NADPH + 2 H+ + biopterin. MF
GO:0047047 oxaloglycolate reductase (decarboxylating) activity Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate. MF
GO:0047046 homoisocitrate dehydrogenase activity Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate. MF
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. MF
GO:0047044 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. MF
GO:0042039 vanadium incorporation into metallo-sulfur cluster The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n). BP
GO:0042038 peptidyl-histidine methylation, to form tele-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine). BP
GO:0047049 (R)-2-hydroxy-fatty-acid dehydrogenase activity Catalysis of the reaction: NAD+ + R-2-hydroxystearate = NADH + H+ + 2-oxostearate. MF
GO:0047048 3-hydroxybenzyl-alcohol dehydrogenase activity Catalysis of the reaction: NADP+ + 3-hydroxybenzyl alcohol = NADPH + H+ + 3-hydroxybenzaldehyde. MF
GO:0006307 DNA dealkylation The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT). BP
GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. BP
GO:0006305 DNA alkylation The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. BP
GO:0006304 DNA modification The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. BP
GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. BP
GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. BP
GO:0006301 postreplication repair Pathways for DNA repair which occur after DNA has replicated, e.g. mismatch repair, and which involve translesion synthesis (TLS-type) DNA polymerases. BP
GO:0006309 DNA fragmentation during apoptosis The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. BP
GO:0006308 DNA catabolic process The chemical reactions and pathways resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. BP
GO:0007181 transforming growth factor beta receptor complex assembly The aggregation and bonding together of a type II transforming growth factor beta (TGFbeta) receptor dimer with a type I TGFbeta receptor dimer, following ligand binding, to form a heterotetrameric TGFbeta receptor complex. BP
GO:0032185 septin cytoskeleton organization and biogenesis The assembly and arrangement of cytoskeletal structures comprising septin complexes and their associated proteins. BP
GO:0031958 corticosteroid receptor signaling pathway Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor. BP
GO:0031959 mineralocorticoid receptor signaling pathway Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor. BP
GO:0031954 positive regulation of protein amino acid autophosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. BP
GO:0031955 short-chain-fatty-acid-CoA ligase activity Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons. MF
GO:0031956 medium-chain-fatty-acid-CoA ligase activity Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12. MF
GO:0031957 very-long-chain-fatty-acid-CoA ligase activity Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18. MF
GO:0031950 negative regulation of glucocorticoid catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. BP
GO:0031951 positive regulation of glucocorticoid catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. BP
GO:0031952 regulation of protein amino acid autophosphorylation Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. BP
GO:0031953 negative regulation of protein amino acid autophosphorylation Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. BP
GO:0009041 uridylate kinase activity Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. MF
GO:0050629 tetrachloroethene reductive dehalogenase activity Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. MF
GO:0050572 L-idonate 5-dehydrogenase activity Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+. MF
GO:0050627 mycothione reductase activity Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione. MF
GO:0050626 trimethylamine-N-oxide reductase (cytochrome c) activity Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+ . MF
GO:0050625 2-hydroxy-1,4-benzoquinone reductase activity Catalysis of the reaction: hydroxybenzoquinone + NADH + H+ = 1,2,4-trihydroxybenzene + NAD+. MF
GO:0050624 vomilenine reductase activity Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+. MF
GO:0050623 berberine reductase activity Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+. MF
GO:0050622 glycine dehydrogenase (cyanide-forming) activity Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. MF
GO:0050621 tryptophan alpha,beta-oxidase activity Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2. MF
GO:0050620 phycocyanobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. MF
GO:0009042 valine-pyruvate transaminase activity Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine. MF
GO:0050577 GDP-L-fucose synthase activity Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. MF
GO:0009044 xylan 1,4-beta-xylosidase activity Catalysis of the hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini. MF
GO:0002686 negative regulation of leukocyte migration Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. BP
GO:0002687 positive regulation of leukocyte migration Any process that activates or increases the frequency, rate, or extent of leukocyte migration. BP
GO:0005656 pre-replicative complex A multiprotein complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. CC
GO:0005657 replication fork The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. CC
GO:0002682 regulation of immune system process Any process that modulates the frequency, rate, or extent of an immune system process. BP
GO:0002683 negative regulation of immune system process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. BP
GO:0002680 pro-T cell lineage commitment The process by which a lymphoid progenitor cell becomes committed to becoming a pro-T cell. BP
GO:0002681 somatic recombination of T cell receptor gene segments The process by which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments. BP
GO:0050574 2-(R)-hydroxypropyl-CoM dehydrogenase activity Catalysis of the reaction: 2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+. MF
GO:0005658 alpha DNA polymerase:primase complex A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. CC
GO:0002688 regulation of leukocyte chemotaxis Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. BP
GO:0002689 negative regulation of leukocyte chemotaxis Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. BP
GO:0035099 hemocyte migration (sensu Arthropoda) The directed movement of hemocytes within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body). In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035098 ESC/E(Z) complex A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. CC
GO:0048798 swim bladder inflation The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. BP
GO:0048799 organ maturation A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. BP
GO:0048796 swim bladder maturation A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. BP
GO:0002351 serotonin production during acute inflammatory response The synthesis or release of serotonin following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002352 B cell negative selection Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion. BP
GO:0035092 sperm chromatin condensation The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication. BP
GO:0002354 central B cell negative selection Any process leading to negative selection of B cells in the bone marrow. BP
GO:0002355 detection of tumor cell The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal. BP
GO:0002356 peripheral B cell negative selection Any process leading to negative selection of B cells in the periphery. BP
GO:0002357 defense response to tumor cell Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism. BP
GO:0007490 tergite morphogenesis The process by which the anatomical structures of the tergite are generated and organized. Morphogenesis pertains to the creation of form. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment. BP
GO:0007491 sternite morphogenesis The process by which the anatomical structures of the sternite are generated and organized. Morphogenesis pertains to the creation of form. The sternite is the plate or sclerite on the underside of a body segment. BP
GO:0007492 endoderm development The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. BP
GO:0007493 endodermal cell fate determination Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0007494 midgut development The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. BP
GO:0007495 visceral mesoderm-endoderm interaction involved in midgut development The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut. BP
GO:0007496 anterior midgut development The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure. BP
GO:0007497 posterior midgut development The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure. BP
GO:0007498 mesoderm development The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. BP
GO:0007499 ectoderm and mesoderm interaction A cell-cell signaling process occuring between the two gastrulation-generated layers of the ectoderm and the mesoderm. BP
GO:0016137 glycoside metabolic process The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. BP
GO:0016136 saponin catabolic process The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection. BP
GO:0016139 glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. BP
GO:0019117 dihydroxyfluorene dioxygenase activity NA MF
GO:0048138 germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst. BP
GO:0048139 female germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad. BP
GO:0048132 female germ-line stem cell division The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. BP
GO:0048133 male germ-line stem cell division The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes. BP
GO:0048130 oocyte microtubule cytoskeleton organization (sensu Insecta) Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. The MTOC nucleates a microtubule network that extends through the ring canals into the 15 nurse cells of the cyst. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048136 male germ-line cyst formation Formation of a cluster of germ-line cells, in the male gonad of an insect, derived from a single founder cell (cystoblast). BP
GO:0048137 spermatocyte division The meiotic divisions undergone by the primary and secondary spermatocytes to produce a cyst of haploid spermatids. BP
GO:0048134 germ-line cyst formation Formation of a cluster of germ-line cells derived from a single founder cell. BP
GO:0048135 female germ-line cyst formation Formation of a cluster of germ-line cells, in the female gonad, derived from a single founder cell. BP
GO:0042799 histone lysine N-methyltransferase activity (H4-K20 specific) Catalysis of the addition of a methyl group onto lysine at position 20 of the histone H4 protein. MF
GO:0004219 pyroglutamyl-peptidase I activity Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide. MF
GO:0004218 cathepsin S activity Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds. MF
GO:0004217 cathepsin L activity Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. MF
GO:0042795 snRNA transcription from RNA polymerase II promoter The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. BP
GO:0042796 snRNA transcription from RNA polymerase III promoter The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. BP
GO:0042797 tRNA transcription from RNA polymerase III promoter The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. BP
GO:0004213 cathepsin B activity Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. MF
GO:0042791 5S class rRNA transcription The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template. BP
GO:0042792 rRNA transcription from mitochondrial promoter The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template. BP
GO:0042793 transcription from plastid promoter The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase. BP
GO:0052572 response to host immune response A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0003973 (S)-2-hydroxy-acid oxidase activity Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2. MF
GO:0003972 RNA ligase (ATP) activity Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m). MF
GO:0003971 double-stranded RNA specific editase activity NA MF
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity Catalysis of the reaction: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine. MF
GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. MF
GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. MF
GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. MF
GO:0003979 UDP-glucose 6-dehydrogenase activity Catalysis of the reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + H+. MF
GO:0003978 UDP-glucose 4-epimerase activity Catalysis of the reaction: UDP-glucose = UDP-galactose. MF
GO:0019440 tryptophan catabolic process to indole-3-acetate The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate. BP
GO:0019441 tryptophan catabolic process to kynurenine The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. BP
GO:0019442 tryptophan catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA. BP
GO:0019444 tryptophan catabolic process to catechol The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol. BP
GO:0019445 tyrosine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate. BP
GO:0019446 tyrosine catabolic process to phosphoenolpyruvate The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate. BP
GO:0019447 D-cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin. BP
GO:0019448 L-cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of L-cysteine, the levorotatory isomer of 2-amino-3-mercaptopropanoic acid. BP
GO:0019449 L-cysteine catabolic process to hypotaurine The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine. BP
GO:0042866 pyruvate biosynthetic process The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate. BP
GO:0042867 pyruvate catabolic process The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate. BP
GO:0042864 pyochelin biosynthetic process The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). BP
GO:0042865 pyochelin catabolic process The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). BP
GO:0042862 achromobactin catabolic process The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore. BP
GO:0042863 pyochelin metabolic process The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). BP
GO:0042860 achromobactin metabolic process The chemical reactions and pathways involving achromobactin, a citrate siderophore. BP
GO:0042861 achromobactin biosynthetic process The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore. BP
GO:0042868 antisense RNA metabolic process The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis. BP
GO:0042869 aldarate transport The directed movement of aldarate into, out of, within or between cells. BP
GO:0050368 tyrosine 2,3-aminomutase activity Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate. MF
GO:0050369 [tyrosine 3-monooxygenase] kinase activity Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]. MF
GO:0050362 tryptophan transaminase activity Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate. MF
GO:0050363 tryptophan dehydrogenase activity Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+. MF
GO:0050360 tryptophan 2'-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3. MF
GO:0050361 tryptophan 2-monooxygenase activity Catalysis of the reaction: L-tryptophan + O2 = indole-3-acetamide + CO2 + H2O. MF
GO:0050366 tyramine N-feruloyltransferase activity Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine. MF
GO:0050367 tyrosine-arginine ligase activity Catalysis of the reaction: ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine. MF
GO:0050364 tryptophan dimethylallyltransferase activity Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan. MF
GO:0050365 tryptophanamidase activity Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH3. MF
GO:0051709 regulation of killing of cells of another organism Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism. BP
GO:0051708 intracellular protein transport in other organism during symbiotic interaction The directed movement of an organism's proteins within a cell of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051703 intraspecies interaction between organisms The processes by which an organism has an observable effect on an organism of the same species. BP
GO:0051702 interaction with symbiont An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. BP
GO:0051701 interaction with host An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. BP
GO:0051700 fructosyl-amino acid oxidase activity Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2. MF
GO:0051707 response to other organism A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. BP
GO:0051705 behavioral interaction between organisms The processes by which an organism has an observable behavioral effect on another organism of the same or different species. BP
GO:0051704 multi-organism process The processes by which an organism has an effect on another organism of the same or different species. BP
GO:0010328 auxin influx transporter activity Enables the directed movement of auxin into a cell. MF
GO:0010329 auxin efflux transporter activity Enables the directed movement of auxin out of a cell. MF
GO:0010322 regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). BP
GO:0010323 negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). BP
GO:0010320 arginine/lysine endopeptidase activity Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles. MF
GO:0010321 regulation of vegetative phase change Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development. BP
GO:0010326 methionine-oxo-acid transaminase activity Catalyzes the reaction: methionine + a 2-oxo acid = 4-methylthio-2-oxobutyrate + an amino acid. MF
GO:0010327 acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity Catalyzes the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate. MF
GO:0010324 membrane invagination The infolding of a membrane, resulting in formation of a vesicle. BP
GO:0010325 raffinose family oligosaccharide biosynthesis The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization). BP
GO:0032843 hydroperoxide reductase Catalysis of the reaction:2RSH + ROOH = RSSR + ROH + H2O, i.e. the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol plus water. MF
GO:0032842 cytochrome bc(1) complex A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. CC
GO:0032841 calcitonin binding Interacting selectively with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid. MF
GO:0032840 intramolecular proline-rich ligand binding Interacting selectively with a proline-rich region within the same polypeptide. MF
GO:0030583 fruiting body development (sensu Bacteria) Formation of a fruiting body by aggregation of individual cells; a starvation response observed in myxobacteria. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0030589 pseudocleavage (sensu Insecta) Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos in the syncytial blastoderm stage. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0047539 2-deoxyglucosidase activity Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol. MF
GO:0047538 2-carboxy-D-arabinitol-1-phosphatase activity Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate. MF
GO:0047533 2,5-dioxovalerate dehydrogenase activity Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+. MF
GO:0047532 2,5-dioxopiperazine hydrolase activity Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine. MF
GO:0047531 2,5-diaminovalerate transaminase activity Catalysis of the reaction: 2,5-diaminopentanoate + 2-oxoglutarate = 5-amino-2-oxopentanoate + L-glutamate. MF
GO:0047530 2,4-diaminopentanoate dehydrogenase activity Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+. MF
GO:0047537 2-aminohexanoate transaminase activity Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate. MF
GO:0047536 2-aminoadipate transaminase activity Catalysis of the reaction: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate. MF
GO:0047535 2-alkyn-1-ol dehydrogenase activity Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + NADH + H+. MF
GO:0047534 2-acetolactate mutase activity Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate. MF
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. CC
GO:0043228 non-membrane-bound organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. CC
GO:0043223 cytoplasmic SCF ubiquitin ligase complex A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). CC
GO:0043222 SMC/kleisin ring complex A molecular ring complex composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1 and Smc3, and the kleisin protein Scc1. CC
GO:0043221 SMC protein binding Interacting selectively with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization. MF
GO:0043220 Schmidt-Lanterman cleft Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman clefts occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. CC
GO:0043227 membrane-bound organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. CC
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. CC
GO:0043225 anion-transporting ATPase activity Catalysis of the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in). MF
GO:0043224 nuclear SCF ubiquitin ligase complex A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). CC
GO:0018772 trioxoheptanoate hydrolase activity Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate. MF
GO:0006963 positive regulation of antibacterial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis. BP
GO:0045979 positive regulation of nucleoside metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. BP
GO:0045978 negative regulation of nucleoside metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. BP
GO:0018778 DL-2 haloacid dehalogenase activity Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate. MF
GO:0045975 positive regulation of mRNA translation, snRNA-mediated Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein. BP
GO:0045974 regulation of mRNA translation, snRNA-mediated Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein. BP
GO:0045977 positive regulation of mitotic cell cycle, embryonic Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle. BP
GO:0045976 negative regulation of progression through embryonic mitotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of progression through the embryonic mitotic cell cycle. BP
GO:0045971 positive regulation of juvenile hormone catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. BP
GO:0045970 negative regulation of juvenile hormone catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. BP
GO:0045973 positive regulation of juvenile hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone. BP
GO:0045972 negative regulation of juvenile hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of juvenile hormone. BP
GO:0030553 cGMP binding Interacting selectively with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). MF
GO:0030552 cAMP binding Interacting selectively with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). MF
GO:0030551 cyclic nucleotide binding Interacting selectively with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. MF
GO:0030550 acetylcholine receptor inhibitor activity Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased. MF
GO:0030557 tRNA modification guide activity Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030556 rRNA modification guide activity Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030555 RNA modification guide activity Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030554 adenyl nucleotide binding Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. MF
GO:0030559 rRNA pseudouridylation guide activity Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030558 RNA pseudouridylation guide activity Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue. MF
GO:0009184 purine deoxyribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009185 ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009187 cyclic nucleotide metabolic process The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. BP
GO:0009180 purine ribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009181 purine ribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009182 purine deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009183 purine deoxyribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009188 ribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009189 deoxyribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0005793 ER-Golgi intermediate compartment A body found in cells where the endoplasmic reticulum is located several micrometers from the Golgi complex, formed from COP II coated vesicles that fuse with each other shortly after their formation. CC
GO:0005792 microsome Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g. CC
GO:0005298 proline:sodium symporter activity Catalysis of the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). MF
GO:0042697 menopause Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50. BP
GO:0005798 Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. CC
GO:0008275 gamma-tubulin small complex A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. CC
GO:0008274 gamma-tubulin ring complex A multiprotein complex composed of gamma-tubulin other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule. CC
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. BP
GO:0008276 protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein. MF
GO:0008271 sulfate porter activity NA MF
GO:0008270 zinc ion binding Interacting selectively with zinc (Zn) ions. MF
GO:0008273 calcium, potassium:sodium antiporter activity Catalysis of the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). MF
GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells. BP
GO:0008278 cohesin complex A protein complex required for sister chromatid cohesion in eukaryotes. CC
GO:0031598 nuclear proteasome regulatory particle The regulatory subcomplex of a proteasome located in the nucleus of a cell. CC
GO:0032304 negative regulation of icosanoid secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of an icosanoid from a cell or group of cells. BP
GO:0032305 positive regulation of icosanoid secretion Any process that activates or increases the frequency, rate or extent of the regulated release of an icosanoid from a cell or group of cells. BP
GO:0032306 regulation of prostaglandin secretion Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells. BP
GO:0032307 negative regulation of prostaglandin secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells. BP
GO:0032300 mismatch repair complex Any complex formed of proteins that act in mismatch repair. CC
GO:0032301 MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. CC
GO:0032302 MutSbeta complex A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. CC
GO:0032303 regulation of icosanoid secretion Any process that modulates the frequency, rate or extent of the regulated release of an icosanoid from a cell or group of cells. BP
GO:0032308 positive regulation of prostaglandin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells. BP
GO:0032309 icosanoid secretion The regulated release of icosanoids, any of a group of C20 polyunsaturated fatty acids. BP
GO:0002538 production of arachidonic acid metabolites during acute inflammatory response The synthesis or release of products of arachidonic acid metabolism following a stimulus during an acute inflammatory response, resulting in an increase in their intracellular or extracellular levels. BP
GO:0019935 cyclic-nucleotide-mediated signaling A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response. BP
GO:0019937 protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid. BP
GO:0019930 cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid The posttranslational modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1. BP
GO:0019931 protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine The posttranslation modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine. BP
GO:0019932 second-messenger-mediated signaling A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell. BP
GO:0019933 cAMP-mediated signaling A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. BP
GO:0002530 regulation of blood pressure during acute phase response Any process that modulates the force with which blood travels through the circulatory system during the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein. BP
GO:0002531 regulation of heart contraction during acute phase response Any process that modulates the frequency, rate or extent of heart contraction during the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein. BP
GO:0002532 production of molecular mediator of acute inflammatory response The synthesis or release of any molecular mediator of the acute inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002533 secretion of lysosomal enzymes during acute inflammatory response The regulated release of lysosomal enzymes by a cell or group of cells during an acute inflammatory response. BP
GO:0002534 cytokine production during acute inflammatory response The synthesis or release of a cytokine following a inflammatory stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002535 platelet activating factor secretion during acute inflammatory response The regulated release of platelet activating factor by a cell or group of cells during an acute inflammatory response. BP
GO:0002536 respiratory burst during acute inflammatory response A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus during an acute inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels. BP
GO:0002537 production of nitric oxide during acute inflammatory response The synthesis or release of nitric oxide following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0042206 halogenated hydrocarbon catabolic process The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. BP
GO:0042207 styrene catabolic process The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene. BP
GO:0042204 s-triazine compound catabolic process The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. BP
GO:0042205 chlorinated hydrocarbon catabolic process The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it. BP
GO:0042202 N-cyclopropylmelamine catabolic process The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide. BP
GO:0042203 toluene catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products. BP
GO:0042200 cyanuric acid catabolic process The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides. BP
GO:0042201 N-cyclopropylmelamine metabolic process The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide. BP
GO:0042208 propylene catabolic process The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. BP
GO:0042209 orcinol catabolic process The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. BP
GO:0006534 cysteine metabolic process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. BP
GO:0003727 single-stranded RNA binding Interacting selectively with single-stranded RNA. MF
GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. BP
GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. BP
GO:0006530 asparagine catabolic process The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid. BP
GO:0006531 aspartate metabolic process The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. BP
GO:0006532 aspartate biosynthetic process The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. BP
GO:0006533 aspartate catabolic process The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. BP
GO:0006538 glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. BP
GO:0006539 glutamate catabolic process via 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate. BP
GO:0003729 mRNA binding Interacting selectively with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA). MF
GO:0000268 peroxisome targeting sequence binding Interacting selectively with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome. MF
GO:0000269 toxin export channel activity NA MF
GO:0000266 mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. BP
GO:0000267 cell fraction A generic term for parts of cells prepared by disruptive biochemical techniques. CC
GO:0000262 mitochondrial chromosome A chromosome found in the mitochondrion of a eukaryotic cell. CC
GO:0004978 adrenocorticotropin receptor activity Combining with adrenocorticotropin to initiate a change in cell activity. MF
GO:0004979 beta-endorphin receptor activity Combining with beta-endorphin to initiate a change in cell activity. MF
GO:0004977 melanocortin receptor activity Combining with melanocortin to initiate a change in cell activity. MF
GO:0004974 leukotriene receptor activity Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. MF
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity NA MF
GO:0004970 ionotropic glutamate receptor activity Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. MF
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity NA MF
GO:0050988 N-terminal peptidyl-methionine carboxylation The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine. BP
GO:0050989 N-terminal protein amino acid carboxylation The carboxylation of the N-terminal amino acid of proteins. BP
GO:0050982 detection of mechanical stimulus The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050983 spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+. BP
GO:0050980 detection of light stimulus during magnetoreception The series of events during magnetoception in which a light stimulus is received by a cell and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field. BP
GO:0050981 detection of electrical stimulus The series of events by which an electrical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050986 isopeptide cross-linking via N-(L-isoglutamyl)-glycine The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25. BP
GO:0050987 enzyme active site formation via O-sulfo-L-serine The transient sulfation of peptidyl-serine to form O-sulfo-L-serine. BP
GO:0050984 peptidyl-serine sulfation The posttranslational sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine. BP
GO:0050985 peptidyl-threonine sulfation The posttranslational sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine. BP
GO:0051169 nuclear transport The directed movement of substances into, out of, or within the nucleus. BP
GO:0004399 histidinol dehydrogenase activity Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. MF
GO:0051163 D-arabitol metabolic process The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. BP
GO:0051162 L-arabitol metabolic process The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. BP
GO:0051161 arabitol metabolic process The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. BP
GO:0051160 L-xylitol catabolic process The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. BP
GO:0004396 hexokinase activity Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. MF
GO:0051166 2,5-dihydroxypyridine catabolic process The chemical reactions and pathways involving 2,5-dihydroxypyridine. BP
GO:0051165 2,5-dihydroxypyridine metabolic process The chemical reactions and pathways involving 2,5-dihydroxypyridine. BP
GO:0004395 hexaprenyldihydroxybenzoate methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. MF
GO:0010049 acquisition of reproductive competence The process by which a plant acquires the ability to respond to a floral inductive signal. BP
GO:0010048 vernalization response The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures. BP
GO:0010043 response to zinc ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. BP
GO:0010042 response to manganese ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. BP
GO:0010041 response to iron(III) ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. BP
GO:0010040 response to iron(II) ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. BP
GO:0010047 fruit dehiscence The process leading to the spontaneous opening of the fruit permitting the escape of seeds. BP
GO:0010046 response to mycotoxin A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin are a toxic chemical substance produced by fungi. BP
GO:0010045 response to nickel ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus. BP
GO:0010044 response to aluminum ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. BP
GO:0018218 peptidyl-cysteine phosphorylation The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine. BP
GO:0018219 peptidyl-cysteine S-acetylation The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine. BP
GO:0018216 peptidyl-arginine methylation Addition of a methyl group to any residue of peptidyl-arginine. BP
GO:0018217 peptidyl-aspartic acid phosphorylation The posttranslational phosphorylation of peptidyl-aspartic acid. BP
GO:0018214 protein amino acid carboxylation The addition of a carboxy group to a protein amino acid. BP
GO:0018215 protein amino acid phosphopantetheinylation The modification of a protein amino acid by phosphopantetheinylation. BP
GO:0018212 peptidyl-tyrosine modification The modification of peptidyl-tyrosine. BP
GO:0018213 peptidyl-valine modification The modification of peptidyl-valine. BP
GO:0018210 peptidyl-threonine modification The modification of peptidyl-threonine. BP
GO:0018211 peptidyl-tryptophan modification The chemical alteration of a tryptophan residue in a peptide. BP
GO:0005375 copper ion transporter activity Enables the directed movement of copper (Cu) ions into, out of, within or between cells. MF
GO:0005372 water transporter activity Enables the directed movement of water (H2O) into, out of, within or between cells. MF
GO:0005371 tricarboxylate carrier activity NA MF
GO:0051299 centrosome separation The process by which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. BP
GO:0051298 centrosome duplication The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. BP
GO:0051295 establishment of meiotic spindle localization The cell cycle process whereby the directed movement of the meiotic spindle to a specific location in the cell occurs. BP
GO:0051294 establishment of spindle orientation The processes that set the alignment of spindle relative to other cellular structures. BP
GO:0004026 alcohol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester. MF
GO:0004027 alcohol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. MF
GO:0051291 protein heterooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of nonidentical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. BP
GO:0004021 alanine transaminase activity Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate. MF
GO:0004022 alcohol dehydrogenase activity Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. MF
GO:0051292 nuclear pore complex assembly The process by which a nuclear pore is formed. BP
GO:0007281 germ cell development The process whose specific outcome is the progression of the immature germ cell over time, from its formation to the mature structure (gamete). BP
GO:0007280 pole cell migration The directed movement of pole cells (germline progenitors in insects) from their site of production at the posterior pole of the embryo through to the site where the gonads will form. BP
GO:0007283 spermatogenesis The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. BP
GO:0007282 cystoblast division The four rounds of incomplete mitosis undergone by the cystoblast to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. BP
GO:0007285 primary spermatocyte growth The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis. BP
GO:0007284 spermatogonial cell division The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form a cyst of secondary spermatogonia (primary spermatocytes). BP
GO:0007287 Nebenkern formation Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern. BP
GO:0007286 spermatid development The process whose specific outcome is the progression of a male gamete over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0007289 spermatid nuclear differentiation The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. BP
GO:0007288 sperm axoneme assembly The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. BP
GO:0001614 purinergic nucleotide receptor activity NA MF
GO:0001615 thyrotropin releasing hormone and secretagogue-like receptors activity NA MF
GO:0001616 growth hormone secretagogue receptor activity NA MF
GO:0001617 growth hormone secretagogue-like receptor activity NA MF
GO:0001610 A1 adenosine receptor activity, G-protein coupled NA MF
GO:0001611 A2A adenosine receptor activity, G-protein coupled NA MF
GO:0001612 A2B adenosine receptor activity, G-protein coupled NA MF
GO:0001613 A3 adenosine receptor activity, G-protein coupled NA MF
GO:0001618 viral receptor activity Combining with a virus component to initiate a change in cell activity. MF
GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. MF
GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. BP
GO:0006884 regulation of cell volume Any process that modulates the volume of a cell. BP
GO:0006885 regulation of pH Any process that modulates the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. BP
GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. BP
GO:0006887 exocytosis The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. BP
GO:0006880 intracellular sequestering of iron ion The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system. BP
GO:0006881 extracellular sequestering of iron ion The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system. BP
GO:0006882 zinc ion homeostasis The regulation of the levels, transport, and metabolism of zinc ions within a cell or between a cell and its external environment. BP
GO:0006883 sodium ion homeostasis The regulation of the levels, transport, and metabolism of sodium ions within a cell or between a cell and its external environment. BP
GO:0016070 RNA metabolic process The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. BP
GO:0016071 mRNA metabolic process The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. BP
GO:0016072 rRNA metabolic process The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. BP
GO:0016073 snRNA metabolic process The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. BP
GO:0016074 snoRNA metabolic process The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing of ribosomal RNA, and they contain a long stretch of sequence complementarity to conserved sequences in mature mRNA. BP
GO:0016075 rRNA catabolic process The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. BP
GO:0016076 snRNA catabolic process The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. BP
GO:0016077 snoRNA catabolic process The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. BP
GO:0016078 tRNA catabolic process The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. BP
GO:0016079 synaptic vesicle exocytosis Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. BP
GO:0015819 lysine transport The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of, within or between cells. BP
GO:0015818 isoleucine transport The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of, within or between cells. BP
GO:0015813 glutamate transport The directed movement of glutamate, the anion of 2-aminopentanedioic acid, into, out of, within or between cells. BP
GO:0015812 gamma-aminobutyric acid transport The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of, within or between cells. BP
GO:0015811 L-cystine transport The directed movement of L-cystine (also known as dicysteine) into, out of, within or between cells. BP
GO:0015810 aspartate transport The directed movement of aspartate, the anion of aspartic acid, into, out of, within or between cells. BP
GO:0015817 histidine transport The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of, within or between cells. BP
GO:0015816 glycine transport The directed movement of glycine, aminoethanoic acid, into, out of, within or between cells. BP
GO:0015814 p-aminobenzoyl-glutamate transport The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of, within or between cells. BP
GO:0051938 L-glutamate import The directed movement of L-glutamate, the levorotatory isomer of the anion of 2-aminopentanedioic acid, into a cell or organelle. BP
GO:0051939 gamma-aminobutyric acid import The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. BP
GO:0051930 regulation of sensory perception of pain Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0051931 regulation of sensory perception Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0051932 synaptic transmission, GABAergic The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). BP
GO:0051933 amino acid uptake during transmission of nerve impulse The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. BP
GO:0051934 catecholamine uptake during transmission of nerve impulse The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. BP
GO:0051935 glutamate uptake during transmission of nerve impulse The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. BP
GO:0051936 gamma-aminobutyric acid uptake during transmission of nerve impulse The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. BP
GO:0051937 catecholamine transport The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. BP
GO:0048659 smooth muscle cell proliferation The multiplication or reproduction of smooth muscle cells, resulting in the rapid expansion of a cell population. BP
GO:0048658 tapetal layer development The process whose specific outcome is the progression of the tapetal layer over time, from its formation to the mature structure. BP
GO:0005247 voltage-gated chloride channel activity NA MF
GO:0002210 behavioral response to wounding A behavioral response resulting from wounding. BP
GO:0005245 voltage-gated calcium channel activity Allows movement of calcium across a cell membrane through a transmembrane channel whose opening and closing is responsive to changes in membrane potential. MF
GO:0005244 voltage-gated ion channel activity A channel in a cell membrane whose opening is governed by the membrane potential. MF
GO:0002215 defense response to nematode A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. BP
GO:0048652 polyphenic determination, influence by genetic factors The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues. BP
GO:0045956 positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. BP
GO:0008079 translation termination factor activity Functions in the termination of translation. MF
GO:0008078 mesodermal cell migration The orderly movement of mesodermal cells from one site to another. BP
GO:0008073 ornithine decarboxylase inhibitor activity The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase. MF
GO:0008071 maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta) Polarization of the follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0008070 maternal determination of dorsal/ventral axis, follicular epithelium, germ-line encoded Polarization of the follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line. BP
GO:0008076 voltage-gated potassium channel complex NA CC
GO:0008074 guanylate cyclase complex, soluble Complex that possesses guanylate cyclase activity and is not bound to a membrane. CC
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. MF
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. MF
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base NA MF
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. MF
GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. MF
GO:0016897 exoribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. MF
GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. MF
GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. MF
GO:0016898 oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule. MF
GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule. MF
GO:0014021 secondary neural tube formation The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals. BP
GO:0014020 primary neural tube formation The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. BP
GO:0014023 neural rod formation (sensu Teleost) The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. BP
GO:0014022 neural plate elongation The process by which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions. BP
GO:0014025 neural keel formation The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. BP
GO:0014024 neural rod cavitation (sensu Teleost) The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube. BP
GO:0014027 secondary neural tube rod cavitation The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube. BP
GO:0014029 neural crest formation The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. BP
GO:0014028 notochord formation The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. BP
GO:0045320 hydrogen-translocating F-type ATPase complex (sensu Viridiplantae) A multisubunit hydrogen-translocating F-type ATPase. F-type ATPases have 2 components, CF(1), the catalytic core, and CF(0), the membrane proton channel. CF(1) has five subunits, alpha(3), beta(3), gamma(1), delta(1), and epsilon(1). CF(0) has three main subunits, a, b and c. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0045321 leukocyte activation A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. BP
GO:0045322 unmethylated CpG binding Interacting selectively with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters. MF
GO:0045323 interleukin-1 receptor complex Complex that binds interleukin-1; comprises an alpha and a beta subunit. CC
GO:0045324 late endosome to vacuole transport The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. BP
GO:0045325 peptidyl-tryptophan hydroxylation The posttranslational hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan. BP
GO:0045326 DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine. BP
GO:0045327 DNA-protein covalent cross-linking via peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue. BP
GO:0045328 cytochrome P450 4A1-heme linkage The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester. BP
GO:0045329 carnitine biosynthetic process The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. BP
GO:0001545 primary ovarian follicle growth Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle). BP
GO:0001540 beta-amyloid binding Interacting selectively with beta-amyloid peptide/protein and/or its precursor. MF
GO:0001541 ovarian follicle development The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. BP
GO:0001542 ovulation (sensu Mammalia) The process leading to the rupture of the follicle, releasing the centrally located oocyte. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0001543 ovarian follicle rupture Disruption of theca cell layer releasing follicular fluid and/or the oocyte. BP
GO:0015048 phthalate dioxygenase reductase activity Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems. MF
GO:0015049 methane monooxygenase activity Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O. MF
GO:0015042 trypanothione-disulfide reductase activity Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide. MF
GO:0015043 leghemoglobin reductase activity Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin. MF
GO:0015044 rubredoxin-NAD+ reductase activity Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+. MF
GO:0015045 rubredoxin-NAD(P)+ reductase activity Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+. MF
GO:0015046 rubredoxin reductase activity Catalysis of the reactions: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+. MF
GO:0015047 NADPH-cytochrome-c2 reductase activity Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2. MF
GO:0035200 leg disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc. BP
GO:0035201 leg disc anterior/posterior lineage restriction Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment. BP
GO:0035202 tracheal sac formation (sensu Insecta) Formation of the tracheal sacs, the first tube-like structures to form in the insect tracheal system. Once cells are determined to their tracheal cell fate, the tracheal sacs arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0035203 regulation of lamellocyte differentiation Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. BP
GO:0035204 negative regulation of lamellocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. BP
GO:0035205 positive regulation of lamellocyte differentiation Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. BP
GO:0035206 regulation of hemocyte proliferation (sensu Arthropoda) Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body). As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035207 negative regulation of hemocyte proliferation (sensu Arthropoda) Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body). As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035208 positive regulation of hemocyte proliferation (sensu Arthropoda) Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body). As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035209 pupal development (sensu Insecta) The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects which undergo a complete metamorphosis. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0016539 intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. BP
GO:0043587 tongue morphogenesis The process by which the anatomical structures of the tongue are generated and organized. Morphogenesis pertains to the creation of form. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. BP
GO:0046569 glyoxal oxidase activity Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2. MF
GO:0046568 3-methylbutanal reductase activity Catalysis of the reaction: isoamyl alcohol (3-methylbutanol) + NADP+ = isovaleraldehyde (3-methylbutanal) + NADPH + H+. MF
GO:0043582 sporangium development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. A sporangium is a plant or fungal structure producing and containing spores. BP
GO:0043583 ear development The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. BP
GO:0043580 periplasmic space organization and biogenesis The assembly and arrangement of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi. BP
GO:0043581 mycelium development The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium is the mass of hyphae that constitutes the vegetative part of a fungus. BP
GO:0046563 methanol oxidase activity Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde. MF
GO:0046562 glucose oxidase activity Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2. MF
GO:0046561 penicillopepsin activity Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen. MF
GO:0016532 superoxide dismutase copper chaperone activity A copper chaperone specifically delivering copper to the Cu-Zn superoxide dismutase. MF
GO:0046567 aphidicolan-16 beta-ol synthase activity Catalysis of the formation of aphidicolan-16 beta-ol from geranylgeranyl diphosphate. MF
GO:0046566 DOPA dioxygenase activity Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid. MF
GO:0046565 3-dehydroshikimate dehydratase activity Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate (protocatechuate) + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. MF
GO:0046564 oxalate decarboxylase activity Catalysis of the reaction: oxalate = formate + CO2. MF
GO:0030184 nitric oxide transporter activity Enables the directed movement of nitric oxide, nitrogen monoxide, into, out of, within or between cells. MF
GO:0030185 nitric oxide transport The directed movement of nitric oxide, nitrogen monoxide, into, out of, within or between cells. BP
GO:0030186 melatonin metabolic process The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine). BP
GO:0030187 melatonin biosynthetic process The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine). BP
GO:0030182 neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron. BP
GO:0030183 B cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a B cell. BP
GO:0030188 chaperone regulator activity Modulates the activity of a molecular chaperone. MF
GO:0030189 chaperone activator activity Increases the activity of a molecular chaperone. MF
GO:0043058 regulation of backward locomotion Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism. BP
GO:0043059 regulation of forward locomotion Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism. BP
GO:0043050 pharyngeal pumping The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes. BP
GO:0043051 regulation of pharyngeal pumping Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes. BP
GO:0043052 thermotaxis The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature. BP
GO:0043053 dauer entry Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development. BP
GO:0043054 dauer exit Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development. BP
GO:0043055 maintenance of dauer Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development. BP
GO:0043056 forward locomotion Anterior movement of an organism, following the direction of the head of the animal. BP
GO:0043057 backward locomotion Posterior movement of an organism, e.g. following the direction of the tail of an animal. BP
GO:0046699 metamorphosis (sensu Amphibia) A change of shape or structure of the whole organism from one developmental stage to another, particularly the rapid post embryonic structural transformation from juvenile to adult form, e.g. the transformation from tadpole to frog. As in, but not restricted to, the amphibia (Amphibia, ncbi_taxonomy_id:8292). BP
GO:0046698 metamorphosis (sensu Insecta) A change of shape or structure from one developmental stage to another, particularly the rapid post embryonic structural transformation from larva to adult form. Metamorphosis is considered to be a change in shape of the whole organism rather than just a part of an organism. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0046695 SLIK (SAGA-like) complex A protein complex similar to the SAGA complex but with a smaller form of Spt7 and no Spt8. Although little is known about the SLIK complex, evidence suggests involvement of the general amino acid control pathway. CC
GO:0046694 sperm incapacitation The process by which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males. BP
GO:0046697 decidualization The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. BP
GO:0046696 lipopolysaccharide receptor complex A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated. CC
GO:0046691 intracellular canaliculus A narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates. CC
GO:0046690 response to tellurium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus. BP
GO:0046693 sperm storage The retention of sperm by a female following mating. BP
GO:0046692 sperm competition Any process that contributes to the success of sperm fertilization in multiply-mated females. BP
GO:0007425 tracheal epithelial cell fate determination (sensu Insecta) Process by which a cell becomes capable of differentiating autonomously into a tracheal cell regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0031275 regulation of lateral pseudopodium formation Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell. BP
GO:0031274 positive regulation of pseudopodium formation Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. BP
GO:0031277 positive regulation of lateral pseudopodium formation Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell. BP
GO:0031276 negative regulation of lateral pseudopodium formation Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell. BP
GO:0031271 lateral pseudopodium formation The extension of a pseudopodium from the lateral area of a cell. BP
GO:0031270 pseudopodium retraction The myosin-based contraction and retraction of the pseudopodium. BP
GO:0031273 negative regulation of pseudopodium formation Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of pseudopodia. BP
GO:0031272 regulation of pseudopodium formation Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. BP
GO:0031279 regulation of cyclase activity Any process that modulates the frequency, rate or extent of cyclase activity. BP
GO:0031278 alpha-1,2-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage. MF
GO:0048349 regulation of paraxial mesodermal cell fate specification Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification. BP
GO:0048348 paraxial mesodermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0048345 regulation of paraxial mesodermal cell fate determination Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination. BP
GO:0048344 paraxial mesodermal cell fate determination Process by which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0048347 negative regulation of paraxial mesodermal cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination. BP
GO:0048346 positive regulation of paraxial mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination. BP
GO:0048341 paraxial mesoderm formation The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. BP
GO:0048340 paraxial mesoderm morphogenesis The process by which the anatomical structures of the paraxial mesoderm are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048343 paraxial mesodermal cell fate commitment The process by which a cell becomes committed to become a paraxial mesoderm cell. BP
GO:0048342 paraxial mesodermal cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell. BP
GO:0009063 amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. BP
GO:0009062 fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. BP
GO:0009061 anaerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. BP
GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. BP
GO:0050519 holo-[acyl-carrier-protein] synthase activity Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = pyrophosphate + holo-citrate lyase. MF
GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. MF
GO:0009065 glutamine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. BP
GO:0009064 glutamine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. BP
GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Catalysis of the reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. MF
GO:0050514 homospermidine synthase (spermidine-specific) activity Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine. MF
GO:0050517 inositol hexakisphosphate kinase activity Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown). MF
GO:0050516 inositol polyphosphate multikinase activity Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. MF
GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. MF
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. MF
GO:0050513 glycoprotein 2-beta-D-xylosyltransferase activity Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP-L-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP. MF
GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP. MF
GO:0007423 sensory organ development The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. BP
GO:0018942 organometal metabolic process The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms. BP
GO:0018943 organotin metabolic process The chemical reactions and pathways involving organotin, an organic compound containing a tin atom. BP
GO:0018940 orcinol metabolic process The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants. BP
GO:0018941 organomercury metabolic process The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom. BP
GO:0018946 aerobic organosilicon metabolic process The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen. BP
GO:0018947 anaerobic organosilicon metabolic process The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen. BP
GO:0018944 tri-n-butyltin metabolic process The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms. BP
GO:0018945 organosilicon metabolic process The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon. BP
GO:0018948 xylene metabolic process The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. BP
GO:0018949 m-xylene metabolic process The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. BP
GO:0019017 segmented viral genome A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion. CC
GO:0019016 non-segmented viral genome A viral genome that consists of one continuous nucleic acid molecule. CC
GO:0019015 viral genome The whole of the genetic information of a virus, contained as either DNA or RNA. CC
GO:0019013 viral nucleocapsid The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle. CC
GO:0019012 virion The complete fully infectious extracellular virus particle. CC
GO:0019010 farnesoic acid O-methyltransferase activity Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine. MF
GO:0019019 tripartite viral genome A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion. CC
GO:0019018 bipartite viral genome A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion. CC
GO:0032115 sorbose reductase activity L-sorbose + NADPH + H+ = D-glucitol + NADP+. The reaction may occur, to a minor extent, in the reverse direction. MF
GO:0032114 regulation of glucose-6-phosphatase activity Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate. BP
GO:0032117 horsetail-astral microtubule array An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement. CC
GO:0032116 cohesin loading complex A complex required for the loading of cohesin onto DNA prior to the establishment of cohesion. Appears to be eukaryotically conserved. CC
GO:0032111 activation of protein histidine kinase activity Any process that initiates the activity of an inactive protein histidine kinase. BP
GO:0032110 regulation of protein histidine kinase activity Any process that modulates the frequency, rate or extent of protein histidine kinase activity. BP
GO:0032113 regulation of carbohydrate phosphatase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate. BP
GO:0032112 negative regulation of protein histidine kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of protein histidine kinase activity. BP
GO:0032119 sequestering of zinc ion The process of binding or confining zinc ions such that they are separated from other components of a biological system. BP
GO:0032118 horsetail-astral microtubule organization and biogenesis The assembly and arrangement of the horsetatil-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis. BP
GO:0000819 sister chromatid segregation The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets. BP
GO:0000818 MIND complex A multiprotein complex in yeast consisting of Mtw1p, Nnf1p, Nsl1p, and Dsn1. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. CC
GO:0000815 ESCRT III complex An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. CC
GO:0000814 ESCRT II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes. CC
GO:0000817 COMA complex A multiprotein complex in yeast consisting of Ctf1p, Okp1p, Mcm1p, Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. CC
GO:0000816 nicotinamide riboside kinase activity Catalysis of the reaction: ATP + nicotinamide riboside = ADP + nicotinamide nucleotide (NMN). MF
GO:0000811 GINS complex A multisubunit complex that associates with replication origins and is required for the initiation of DNA replication. CC
GO:0000810 diacylglycerol pyrophosphate phosphatase activity Catalysis of the reaction: diacylglycerol pyrophosphate + H20 = 3-sn-phosphatidate + phosphate. MF
GO:0000813 ESCRT I complex An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. CC
GO:0000812 SWR1 complex A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. CC
GO:0005944 1-phosphatidylinositol-4-phosphate kinase, class IB complex NA CC
GO:0005945 6-phosphofructokinase complex A allosteric homotetrameric molecule with glycolytic activity. CC
GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) An enzyme complex that in yeast is composed of three or four polypeptides: TPS1, TPS2, TPS3 and TSL1. Catalyzes the formation of alpha,alpha-trehalose 6-phosphate and UDP from UDP-glucose and D-glucose 6-phosphate. CC
GO:0005947 alpha-ketoglutarate dehydrogenase complex (sensu Eukaryota) Complex that possesses alpha-ketoglutarate dehydrogenase activity. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0005940 septin ring A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. CC
GO:0005941 unlocalized protein complex Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products. CC
GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). CC
GO:0005943 1-phosphatidylinositol-4-phosphate kinase, class IA complex NA CC
GO:0005948 acetolactate synthase complex A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. CC
GO:0006767 water-soluble vitamin metabolic process The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. BP
GO:0006766 vitamin metabolic process The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. BP
GO:0006761 dihydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate. BP
GO:0006760 folic acid and derivative metabolic process The chemical reactions and pathways involving folic acid and its derivatives. BP
GO:0006769 nicotinamide metabolic process The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms. BP
GO:0006768 biotin metabolic process The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. BP
GO:0005498 sterol carrier activity NA MF
GO:0005499 vitamin D binding Interacting selectively with vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol. MF
GO:0005496 steroid binding Interacting selectively with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. MF
GO:0005497 androgen binding Interacting selectively with any androgen, male sex hormones. MF
GO:0000385 spliceosomal catalysis Catalysis of a transesterification reaction that is part of spliceosomal mRNA splicing. MF
GO:0000384 first spliceosomal transesterification activity Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. MF
GO:0000387 spliceosomal snRNP biogenesis The formation and assembly from one or more snRNA and multiple protein components of a ribonucleoprotein complex that in involved in formation of the spliceosome. BP
GO:0000386 second spliceosomal transesterification activity Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. MF
GO:0000381 regulation of alternative nuclear mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. BP
GO:0000380 alternative nuclear mRNA splicing, via spliceosome The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. BP
GO:0000383 U2-type nuclear mRNA 3'-splice site recognition Recognition of the intron 3'-splice site by components of the assembling U2-type spliceosome. BP
GO:0000382 U12-type nuclear mRNA 3'-splice site recognition Recognition of the intron 3'-splice site by components of the assembling U12-type spliceosome. BP
GO:0000389 nuclear mRNA 3'-splice site recognition Recognition of the intron 3'-splice site by components of the assembling U12-type spliceosome. BP
GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). BP
GO:0052324 cell wall cellulose biosynthesis The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. BP
GO:0048628 myoblast maturation A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. BP
GO:0048629 trichome patterning (sensu Magnoliophyta) The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0052325 cell wall pectin biosynthesis The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. BP
GO:0048622 reproductive sporulation The formation of reproductive spores. BP
GO:0048623 seed germination on parent plant The process by which a seed germinates before being shed from the parent plant. BP
GO:0005230 extracellular ligand-gated ion channel activity NA MF
GO:0048621 post-embryonic gut morphogenesis The process, occurring during the post-embryonic phase, by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. BP
GO:0048626 myoblast cell fate specification The process whereby a cell becomes capable of differentiating autonomously into a myoblast cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. BP
GO:0048627 myoblast development The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. BP
GO:0005234 glutamate-gated ion channel activity NA MF
GO:0048625 myoblast cell fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. BP
GO:0000038 very-long-chain fatty acid metabolic process The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater. BP
GO:0000036 acyl carrier activity NA MF
GO:0000035 acyl binding Interacting selectively with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. MF
GO:0000034 adenine deaminase activity Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3. MF
GO:0000033 alpha-1,3-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage. MF
GO:0000032 cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid. BP
GO:0000031 mannosylphosphate transferase activity Catalysis of the transfer of an mannosylphosphate group from one compound to another. MF
GO:0000030 mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. MF
GO:0004729 protoporphyrinogen oxidase activity Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2. MF
GO:0004728 receptor signaling protein tyrosine phosphatase activity NA MF
GO:0004727 prenylated protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. MF
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity NA MF
GO:0004725 protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. MF
GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity Catalysis of the removal of a serine- or threonine-bound phosphate group from a protein; action dependent on magnesium. MF
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. MF
GO:0004722 protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. MF
GO:0004721 phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. MF
GO:0004720 protein-lysine 6-oxidase activity Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2. MF
GO:0043160 acrosomal lumen The volume enclosed within the acrosome membrane. CC
GO:0043161 proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. BP
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. BP
GO:0043163 cell envelope organization and biogenesis The assembly and arrangement of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present. BP
GO:0043164 cell wall biosynthetic process (sensu ProteoBacteria) The chemical reactions and pathways resulting in the formation of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). BP
GO:0043165 outer membrane biogenesis (sensu ProteoBacteria) The assembly of an outer membrane, a lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). BP
GO:0032207 regulation of telomere maintenance via recombination Any process that modulates the frequency, rate or extent of recombinational processes involved in the maintenance of proper telomeric length. BP
GO:0043166 H4/H2A histone acetyltransferase activity Catalysis of the addition of an acetyl group to a histone, specific for histones H4 and (to a lesser extent) H2A. MF
GO:0043167 ion binding Interacting selectively with ions, charged atoms or groups of atoms. MF
GO:0051318 G1 phase Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. BP
GO:0051319 G2 phase Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis). BP
GO:0051310 metaphase plate congression The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle. BP
GO:0051311 meiotic metaphase plate congression The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis. BP
GO:0051312 chromosome decondensation The alteration of chromosome structure from the condensed form to a relaxed disperse form. BP
GO:0051313 attachment of spindle microtubules to chromosome The process by which spindle microtubules become physically associated with a chromosome. BP
GO:0051314 attachment of spindle microtubules to mitotic chromosome The cell cycle process whereby spindle microtubules become physically associated with a chromosome during mitosis. BP
GO:0051315 attachment of spindle microtubules to kinetochore during mitosis The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs. BP
GO:0051316 attachment of spindle microtubules to kinetochore during meiotic chromosome segregation The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiotic chromosome segregation. BP
GO:0051317 attachment of spindle microtubules to meiotic chromosome The cell cycle process whereby spindle microtubules become physically associated with a chromosome during meiosis. BP
GO:0007568 aging The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. BP
GO:0007569 cell aging Progression of the cell from its inception to the end of its lifespan. BP
GO:0015208 guanine transporter activity Enables the directed movement of guanine, 2-amino-6-hydroxypurine, into, out of, within or between cells. MF
GO:0015209 cytosine transporter activity Enables the directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of, within or between cells. MF
GO:0015206 allantoin transporter activity Enables the directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of, within or between cells. MF
GO:0015207 adenine transporter activity Enables the directed movement of adenine, 6-aminopurine, into, out of, within or between cells. MF
GO:0007566 embryo implantation Attachment of the blastocyst to the uterine lining. BP
GO:0007567 parturition The process of giving birth to live offspring or eggs. BP
GO:0007560 imaginal disc morphogenesis The process by which the anatomical structures derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. BP
GO:0007561 imaginal disc eversion The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis. BP
GO:0007562 eclosion The emergence of an insect from a pupa-case or of a larva from an egg. BP
GO:0007563 regulation of eclosion Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg. BP
GO:0018009 N-terminal peptidyl-L-cysteine N-palmitoylation The palmitoylation of the N-terminal cysteine of proteins to form the derivative N-palmitoyl-cysteine. BP
GO:0018008 N-terminal peptidyl-glycine N-myristoylation The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine. BP
GO:0018007 N-terminal peptidyl-glycine N-glucuronylation The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine. BP
GO:0018006 N-terminal protein amino acid glucuronylation The glucuronylation of the N-terminal amino acid of proteins. BP
GO:0018005 N-terminal peptidyl-glycine N-formylation The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine. BP
GO:0018004 N-terminal protein formylation The formylation of the N-terminal amino acid of proteins. BP
GO:0018003 peptidyl-lysine N6-acetylation The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine; catalyzed by tubulin N-acetyltransferase. BP
GO:0018002 N-terminal peptidyl-glutamic acid acetylation The acetylation of the N-terminal glutamic acid of proteins; catalyzed by peptide alpha-N-acetyltransferase. BP
GO:0018001 N-terminal peptidyl-valine acetylation The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine. BP
GO:0018000 N-terminal peptidyl-tyrosine acetylation The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine. BP
GO:0019758 glycosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. BP
GO:0019759 glycosinolate catabolic process The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. BP
GO:0019754 one-carbon compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds containing a single carbon atom. BP
GO:0019755 one-carbon compound transport The directed movement of one-carbon compounds into, out of, within or between cells. BP
GO:0019756 cyanogenic glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. BP
GO:0019757 glycosinolate metabolic process The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. BP
GO:0019750 chloroplast transport The directed movement of a chloroplast, a chlorophyll containing plastid found in cells of algae and higher plants, into, out of, within or between cells. BP
GO:0019751 polyol metabolic process The chemical reactions and pathways involving a polyol, any polyhydric alcohol. BP
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). BP
GO:0019753 one-carbon compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds containing a single carbon atom. BP
GO:0001805 positive regulation of type III hypersensitivity Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response. BP
GO:0001804 negative regulation of type III hypersensitivity Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response. BP
GO:0001807 regulation of type IV hypersensitivity Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response. BP
GO:0001806 type IV hypersensitivity An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation. BP
GO:0001801 positive regulation of type IIb hypersensitivity Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response. BP
GO:0001800 negative regulation of type IIb hypersensitivity Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response. BP
GO:0001803 regulation of type III hypersensitivity Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response. BP
GO:0001802 type III hypersensitivity An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue. BP
GO:0001809 positive regulation of type IV hypersensitivity Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response. BP
GO:0001808 negative regulation of type IV hypersensitivity Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response. BP
GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. MF
GO:0017177 alpha-glucosidase II complex A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins. CC
GO:0017174 glycine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. MF
GO:0017172 cysteine dioxygenase activity Catalysis of the reaction: L-cysteine + O2 = 3-sulfinoalanine. MF
GO:0017173 DRAP deaminase activity Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate. MF
GO:0017170 KU70 binding Interacting selectively with Ku70, a protein involved in non-homologous DNA end joining. MF
GO:0017171 serine hydrolase activity NA MF
GO:0017178 diphthine-ammonia ligase activity Catalysis of the reaction: ATP + diphthine + NH3 = ADP + phosphate + diphthamide. MF
GO:0017179 peptidyl-diphthine metabolic process The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue. BP
GO:0031079 picornain 3C activity Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. MF
GO:0031078 histone deacetylase activity (H3-K14 specific) Catalysis of the removal of an acetyl group from lysine at position 14 of the histone H3 protein. MF
GO:0031073 cholesterol 26-hydroxylase activity Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol. MF
GO:0031072 heat shock protein binding Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. MF
GO:0031071 cysteine desulfurase activity Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. MF
GO:0031070 intronic snoRNA processing The biogenesis of a snoRNA molecue which resides within, and is processed from, the intron of a pre-mRNA. BP
GO:0031077 post-embryonic eye development (sensu Actinopterygii) The process occuring during the post-embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. As in, but not restricted to, the ray-finned fishes (Actinopterygii, ncbi_taxonomy_id:7898). BP
GO:0031076 embryonic eye development (sensu Actinopterygii) The process occuring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. As in, but not restricted to, the ray-finned fishes (Actinopterygii, ncbi_taxonomy_id:7898). BP
GO:0031075 eye development (sensu Actinopterygii) The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. As in, but not restricted to, the ray-finned fishes (Actinopterygii, ncbi_taxonomy_id:7898). BP
GO:0031074 nucleocytoplasmic shuttling complex Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores. CC
GO:0015996 chlorophyll catabolic process The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products. BP
GO:0015997 ubiquinone biosynthetic process monooxygenase activity NA MF
GO:0015994 chlorophyll metabolic process The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. BP
GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. BP
GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells. BP
GO:0015993 molecular hydrogen transport The directed movement of molecular hydrogen (H2) into, out of, within or between cells. BP
GO:0015990 electron transport coupled proton transport NA BP
GO:0015991 ATP hydrolysis coupled proton transport NA BP
GO:0015999 eta DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). MF
GO:0009261 ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009260 ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009263 deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009262 deoxyribonucleotide metabolic process The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009265 2'-deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009264 deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009267 cellular response to starvation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. BP
GO:0009266 response to temperature stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. BP
GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. BP
GO:0009268 response to pH A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. BP
GO:0007548 sex differentiation The establishment of the sex of an organism by physical differentiation. BP
GO:0046880 regulation of follicle-stimulating hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone. BP
GO:0046881 positive regulation of follicle-stimulating hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone. BP
GO:0046882 negative regulation of follicle-stimulating hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone. BP
GO:0007549 dosage compensation Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes. BP
GO:0046884 follicle-stimulating hormone secretion The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. BP
GO:0046885 regulation of hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. BP
GO:0046886 positive regulation of hormone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. BP
GO:0046887 positive regulation of hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells. BP
GO:0046888 negative regulation of hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells. BP
GO:0046889 positive regulation of lipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. BP
GO:0009702 L-arabinokinase activity Catalysis of the reaction: ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate. MF
GO:0032367 intracellular cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells. BP
GO:0032364 oxygen homeostasis Any of the processes involved in the maintenance of an internal equilibrium of oxygen within an organism or cell. BP
GO:0009701 isoflavonoid phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. BP
GO:0032362 FAD catabolic process The chemical reactions and pathways resulting in the breakdown of FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. BP
GO:0009707 chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. CC
GO:0008608 attachment of spindle microtubules to kinetochore The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex. BP
GO:0008609 alkylglycerone-phosphate synthase activity Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. MF
GO:0032360 provirus maintenance The molecular events that maintain a viral genome integrated into a host genome. BP
GO:0043630 ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring during the process of polyadenylation-dependent non-coding RNA catabolism. BP
GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. BP
GO:0043632 modification-dependent macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule. BP
GO:0032361 pyridoxal phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. BP
GO:0043634 polyadenylation-dependent ncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target RNA. BP
GO:0008605 protein kinase CK2 regulator activity Modulation of the activity of the enzyme protein kinase CK2. MF
GO:0043636 bisphenol A catabolic process The chemical reactions and pathways resulting in the breakdown of bisphenol A, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins. BP
GO:0043637 puromycin metabolic process The chemical reactions and pathways involving puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. BP
GO:0045289 luciferin monooxygenase activity Catalysis of the oxidation of luciferin. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation. MF
GO:0045286 ubiquinol-cytochrome-c reductase complex (sensu Bacteria) An enzyme complex that contains cytochrome b/b6 and cytochrome c1. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045285 ubiquinol-cytochrome-c reductase complex An enzyme complex that contains cytochrome b/b6 and cytochrome c1. CC
GO:0045284 fumarate reductase complex (sensu Bacteria) A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:00224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045283 fumarate reductase complex A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:004224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). CC
GO:0045282 succinate dehydrogenase complex (sensu Bacteria) A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045281 succinate dehydrogenase complex A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones. CC
GO:0045280 NADH dehydrogenase complex (ubiquinone) (sensu Bacteria) Complex that possesses NADH dehydrogenase (ubiquinone) activity, as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0032759 positive regulation of TRAIL production Any process that activates or increases the frequency, rate, or extent of TRAIL production. BP
GO:0032758 positive regulation of interleukin-9 production Any process that activates or increases the frequency, rate, or extent of interleukin-9 production. BP
GO:0032753 positive regulation of interleukin-4 production Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. BP
GO:0032752 positive regulation of interleukin-3 production Any process that activates or increases the frequency, rate, or extent of interleukin-3 production. BP
GO:0032751 positive regulation of interleukin-27 production Any process that activates or increases the frequency, rate, or extent of interleukin-27 production. BP
GO:0032750 positive regulation of interleukin-26 production Any process that activates or increases the frequency, rate, or extent of interleukin-26 production. BP
GO:0032757 positive regulation of interleukin-8 production Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. BP
GO:0032756 positive regulation of interleukin-7 production Any process that activates or increases the frequency, rate, or extent of interleukin-7 production. BP
GO:0032755 positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. BP
GO:0032754 positive regulation of interleukin-5 production Any process that activates or increases the frequency, rate, or extent of interleukin-5 production. BP
GO:0019778 APG12 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. MF
GO:0008678 2-deoxy-D-gluconate 3-dehydrogenase activity Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+. MF
GO:0019776 APG8 conjugating enzyme activity Catalysis of the covalent attachment of the ubiquitin-like protein APG8 to substrate molecules; phosphatidylethanolamine is a known substrate. MF
GO:0019777 APG12 conjugating enzyme activity Catalysis of the covalent attachment of the ubiquitin-like protein APG12 to other proteins. MF
GO:0046718 entry of virus into host cell The process by which a virion enters a host cell, including virion attachment and penetration. BP
GO:0046719 regulation of viral protein levels in host cell Any virus-mediated process that modulates the levels of viral proteins in a cell. BP
GO:0046710 GDP metabolic process The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. BP
GO:0046711 GDP biosynthetic process The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate. BP
GO:0046712 GDP catabolic process The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate. BP
GO:0046713 boron transport The directed movement of boron into, out of, within or between cells. Boron is a group 13 element, with properties which are borderline between metals and non-metals. BP
GO:0046714 boron binding Interacting selectively with boron, the group 13 element with properties which are borderline between metals and non-metals. MF
GO:0046715 boron transporter activity Catalysis of the transport of boron across a membrane against the concentration gradient. MF
GO:0046716 muscle maintenance The maintenance of muscle fibers after their formation to allow normal functioning. BP
GO:0046717 acid secretion The regulated release of acid by a cell or group of cells. BP
GO:0002608 negative regulation of myeloid dendritic cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. BP
GO:0002609 positive regulation of myeloid dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. BP
GO:0002606 positive regulation of dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. BP
GO:0002607 regulation of myeloid dendritic cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. BP
GO:0002604 regulation of dendritic cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. BP
GO:0002605 negative regulation of dendritic cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. BP
GO:0002602 negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. BP
GO:0002603 positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. BP
GO:0002600 positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib. BP
GO:0002601 regulation of antigen processing and presentation of polysaccharide antigen via MHC class II Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II. BP
GO:0035011 melanotic encapsulation of foreign target Formation of a multilayered, melanized sheath of cells around a foreign invader. BP
GO:0030062 tricarboxylic acid cycle enzyme complex (sensu Eukaryota) Any of the heteromeric enzymes that act in the TCA cycle, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0035013 myosuppressin receptor activity Combining with the peptide myosuppressin to initiate a change in cell activity. MF
GO:0030060 L-malate dehydrogenase activity Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. MF
GO:0035015 elongation of arista core The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. BP
GO:0035014 phosphoinositide 3-kinase regulator activity Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. MF
GO:0030065 chlorite dismutase activity Catalysis of the reaction: ClO2- = Cl- + O2. MF
GO:0035016 elongation of arista lateral The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. BP
GO:0035019 somatic stem cell maintenance The process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. BP
GO:0035018 adult cuticle pattern formation (sensu Insecta) The process that gives rise to the patterns of cell differentiation that will arise in the adult cuticle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030069 lysogeny The incorporation of a bacteriophage genome into the genome of its bacterial host organism. BP
GO:0009112 nucleobase metabolic process The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. BP
GO:0050249 Renilla-luciferin sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + Renilla luciferin = adenosine 3',5'-bisphosphate + luciferyl sulfate. MF
GO:0050248 Renilla-luciferin 2-monooxygenase activity Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light. MF
GO:0009119 ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0050246 questin monooxygenase activity Catalysis of the reaction: questin + NADPH + O2 = sulochrin + NADP+ + H2O. MF
GO:0004529 exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. MF
GO:0004528 phosphodiesterase I activity Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. MF
GO:0004525 ribonuclease III activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. MF
GO:0004527 exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. MF
GO:0004526 ribonuclease P activity Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. MF
GO:0004521 endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. MF
GO:0004520 endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. MF
GO:0004523 ribonuclease H activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. MF
GO:0004522 pancreatic ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. MF
GO:0009922 fatty acid elongase activity Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). MF
GO:0009923 fatty acid elongase complex A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids. CC
GO:0009920 cell plate formation (sensu Magnoliophyta) The cell cycle process whereby the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009921 auxin efflux carrier complex The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell. CC
GO:0009926 auxin polar transport The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally. BP
GO:0009927 histidine phosphotransfer kinase activity Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. MF
GO:0009924 octadecanal decarbonylase activity Catalysis of the reaction: octadecanal = heptadecane + CO. MF
GO:0009925 basal plasma membrane Part of the plasma membrane at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. CC
GO:0009928 cell surface (sensu Magnoliophyta) The external part of the cell wall and/or plasma membrane. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0042714 dosage compensation complex assembly The processes by which the complex that mediates dosage compensation is assembled on one or more X chromosomes. BP
GO:0042715 dosage compensation complex assembly (sensu Nematoda) The processes by which the complex that mediates dosage compensation is assembled on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0004295 trypsin activity Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa. MF
GO:0004294 tripeptidyl-peptidase II activity Catalysis of the release of an N-terminal tripeptide from a polypeptide. MF
GO:0042710 biofilm formation A process whereby microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. BP
GO:0042711 maternal behavior Female behaviors associated with the care and rearing of offspring. BP
GO:0004291 subtilisin activity Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides. MF
GO:0004290 kexin activity Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors. MF
GO:0042718 yolk granule Discrete structures that partition the yolk of oocytes and ova, which may or may not be membrane enclosed. CC
GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. CC
GO:0004298 threonine endopeptidase activity Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles. MF
GO:0050498 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated. MF
GO:0050499 oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H. MF
GO:0050490 1,4-lactonase activity Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid. MF
GO:0050491 sulcatone reductase activity Catalysis of the reaction: NAD+ + sulcatol = NADH + H+ + sulcatone. MF
GO:0050492 glycerol-1-phosphate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate. MF
GO:0050493 GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine The formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0050494 GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine The formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0050495 peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine The formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine. BP
GO:0050496 peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine The posttranslational modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide. BP
GO:0050497 transferase activity, transferring alkylthio groups Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor). MF
GO:0018577 catechol 2,3-dioxygenase activity Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde. MF
GO:0018576 catechol 1,2-dioxygenase activity Catalysis of the reaction: catechol + O2 = cis,cis-muconate. MF
GO:0018575 chlorocatechol 1,2-dioxygenase activity Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate. MF
GO:0018574 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate. MF
GO:0018573 2-aminophenol 1,6-dioxygenase activity Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde. MF
GO:0018572 3,5-dichlorocatechol 1,2-dioxygenase activity Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H + 2,4-dichloro-cis,cis-muconate. MF
GO:0018571 2,3-dihydroxy-p-cumate dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate. MF
GO:0018570 p-cumate 2,3-dioxygenase activity Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate. MF
GO:0030737 iodophenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-iodophenol = S-adenosyl-L-homocysteine + 2-iodophenol methyl ether. MF
GO:0018579 protocatechuate 4,5-dioxygenase activity Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde. MF
GO:0018578 protocatechuate 3,4-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate. MF
GO:0019226 transmission of nerve impulse The sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation. BP
GO:0019227 action potential propagation A neurological process that causes the sequential depolarization of a neuron's cell membrane along an axon. BP
GO:0019220 regulation of phosphate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates. BP
GO:0019221 cytokine and chemokine mediated signaling pathway Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor. BP
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. BP
GO:0019228 generation of action potential The process that modulates the membrane potential involved in the propagation of a signal in a neuron. BP
GO:0042495 detection of triacylated bacterial lipoprotein The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are triacylated lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs). BP
GO:0030736 phenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole. MF
GO:0007176 regulation of epidermal growth factor receptor activity Any process that modulates the frequency, rate or extent of EGF receptor activity. BP
GO:0007175 negative regulation of epidermal growth factor receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity. BP
GO:0007174 epidermal growth factor ligand processing The proteolysis of epidermal growth factor after its internalization via binding to its receptor. BP
GO:0007173 epidermal growth factor receptor signaling pathway The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands. BP
GO:0007172 signal complex formation Formation of a complex by dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors; the resulting complex is capable of relaying a signal within a cell. BP
GO:0007171 transmembrane receptor protein tyrosine kinase activation (dimerization) NA BP
GO:0007179 transforming growth factor beta receptor signaling pathway The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands. BP
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. BP
GO:0052250 modulation of signal transduction pathway in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, occurring in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052251 induction by organism of defense response of other organism during symbiotic interaction The activation by an organism of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052252 negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052253 negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052254 negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052255 modulation by organism of defense response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the defense response of a second organism, the response mounted by that organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction. BP
GO:0052256 modulation by organism of inflammatory response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052257 pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction NA BP
GO:0052258 negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction NA BP
GO:0052259 positive regulation by organism of inflammatory response of other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. MF
GO:0008942 nitrite reductase [NAD(P)H] activity Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = NO2(-) (nitrite) + 3 NAD(P)H + 3 H+. MF
GO:0008941 nitric oxide dioxygenase activity Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 NO3- + NADP+. MF
GO:0008947 omptin activity Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys. MF
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. MF
GO:0000172 ribonuclease MRP complex A ribonucleoprotein complex that performs the first cleavage in rRNA transcript processing and is also involved in mitochondrial RNA processing. CC
GO:0000173 inactivation of MAPK activity during osmolarity sensing Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing. BP
GO:0000170 sphingosine hydroxylase activity Catalysis of the hydroxylation of sphingolipid long chain bases. MF
GO:0000171 ribonuclease MRP activity Catalysis of the first cleavage in rRNA transcript processing, also involved in mitochondrial RNA processing. MF
GO:0000176 nuclear exosome (RNase complex) Complex of 3'-5' exoribonucleases found in the nucleus. CC
GO:0000177 cytoplasmic exosome (RNase complex) Complex of 3'-5' exoribonucleases found in the cytoplasm. CC
GO:0000175 3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. MF
GO:0004888 transmembrane receptor activity Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. MF
GO:0004889 nicotinic acetylcholine-activated cation-selective channel activity NA MF
GO:0004882 androgen receptor activity Combining with an androgen to initiate a change in cell activity. MF
GO:0004883 glucocorticoid receptor activity Combining with a glucocorticoid to initiate a change in cell activity. MF
GO:0004880 juvenile hormone receptor activity Combining with juvenile hormone to initiate a change in cell activity. MF
GO:0004886 retinoid-X receptor activity NA MF
GO:0004887 thyroid hormone receptor activity Combining with thyroid hormone to initiate a change in cell activity. MF
GO:0004884 ecdysteroid hormone receptor activity Combining with ecdysteroid hormone to initiate a change in cell activity. MF
GO:0008946 oligonucleotidase activity Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates; also hydrolyzes NAD+ to NMN and AMP. MF
GO:0008945 oligopeptidase B activity Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline. MF
GO:0018638 toluene 4-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene. MF
GO:0018639 xylene monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = benzyl alcohol or xylene + 1/2 O2 = methylbenzyl alcohol. MF
GO:0018634 alpha-pinene monooxygenase [NADH] activity Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide. MF
GO:0018635 limonene 1,2-monooxygenase activity Catalysis of the reaction: (+)-(4R)-limonene + NADH + O2 = NAD+ + OH- + (4R)-limonene-1,2-epoxide. MF
GO:0018636 phenanthrene 9,10-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. MF
GO:0018637 1-hydroxy-2-naphthoate hydroxylase activity Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene. MF
GO:0018630 3,5-xylenol methylhydroxylase activity Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol. MF
GO:0018631 phenylacetate hydroxylase activity Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate. MF
GO:0018632 4-nitrophenol 4-monooxygenase activity Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + NO2(-) (nitrite) + p-benzoquinone. MF
GO:0018633 dimethyl sulfide monooxygenase activity Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde. MF
GO:0051509 tomatidine UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine. MF
GO:0051508 stigmasterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-stigmasterol. MF
GO:0051501 diterpene phytoalexin metabolic process The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units. BP
GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine resides in charged tRNA. MF
GO:0051503 adenine nucleotide transport The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of, within or between cells. BP
GO:0051502 diterpene phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses. BP
GO:0051505 cholesterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol. MF
GO:0051504 diterpene phytoalexin precursor biosynthetic process pathway A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins. BP
GO:0051507 beta-sitosterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-beta-sitosterol. MF
GO:0051506 ergosterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol. MF
GO:0015419 sulfate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). MF
GO:0015418 quaternary-ammonium-compound-transporting ATPase activity Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in). MF
GO:0015417 polyamine-transporting ATPase activity Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). MF
GO:0015416 phosphonate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). MF
GO:0015415 phosphate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in). MF
GO:0015414 nitrate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in). MF
GO:0015413 nickel-transporting ATPase activity Catalysis of the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). MF
GO:0015412 molybdate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in). MF
GO:0015411 taurine-transporting ATPase activity Catalysis of the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in). MF
GO:0015410 manganese-transporting ATPase activity Catalysis of the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in). MF
GO:0042488 positive regulation of odontogenesis (sensu Vertebrata) Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0016149 translation release factor activity, codon specific A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. MF
GO:0016144 S-glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. BP
GO:0016145 S-glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. BP
GO:0016140 O-glycoside metabolic process The chemical reactions and pathways involving O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group. BP
GO:0016141 O-glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group. BP
GO:0016142 O-glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group. BP
GO:0016143 S-glycoside metabolic process The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group. BP
GO:0042481 regulation of odontogenesis Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. BP
GO:0004321 fatty-acyl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. MF
GO:0046260 trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene. BP
GO:0046263 nitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached. BP
GO:0046265 thiocyanate catabolic process The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid. BP
GO:0046267 triethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. BP
GO:0046269 toluene-4-sulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule. BP
GO:0042485 positive regulation of odontogenesis (sensu Protostomia) Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth, any hard calcareous or chitinous organ found in the mouth and used in feeding or procuring food, e.g. a mollusk or starfish tooth. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0030261 chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. BP
GO:0047612 acid-CoA ligase (GDP-forming) activity Catalysis of the reaction: GTP + an acid + CoA = GDP + phosphate + acyl-CoA. MF
GO:0030263 apoptotic chromosome condensation The compaction of chromatin during apoptosis. BP
GO:0030262 apoptotic nuclear changes The morphological and physiological alterations undergone by the nucleus during apoptosis. BP
GO:0030265 rhodopsin mediated G-protein signaling, coupled to IP3 second messenger The series of molecular signals generated as a consequence of light impinging on rhodopsin molecules in a photoreceptor cell, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate. BP
GO:0030264 nuclear fragmentation during apoptosis The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. BP
GO:0030267 glyoxylate reductase (NADP) activity Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. MF
GO:0030266 quinate 5-dehydrogenase activity Catalysis of the reaction: quinate + NAD+ = 5-dehydroquinate + NADH + H+. MF
GO:0030269 tetrahydromethanopterin S-methyltransferase activity Catalysis of the reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. 2-(methylthio)ethanesulfonate is also known as methyl-CoM. MF
GO:0015707 nitrite transport The directed movement of nitrite into, out of, within or between cells. BP
GO:0042487 regulation of odontogenesis (sensu Vertebrata) Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0047610 acetylsalicylate deacetylase activity Catalysis of the reaction: acetylsalicylate + H2O = salicylate + acetate. MF
GO:0015706 nitrate transport The directed movement of nitrate into, out of, within or between cells. BP
GO:0047611 acetylspermidine deacetylase activity Catalysis of the reaction: N1-acetylspermidine + H2O = acetate + spermidine. MF
GO:0047617 acyl-CoA hydrolase activity Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. MF
GO:0047614 aconitate delta-isomerase activity Catalysis of the reaction: trans-aconitate = cis-aconitate. MF
GO:0047615 actinomycin lactonase activity Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone. MF
GO:0047736 cellobiose epimerase activity Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose. MF
GO:0006556 S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. BP
GO:0003701 RNA polymerase I transcription factor activity Functions to initiate or regulate RNA polymerase I transcription. MF
GO:0006554 lysine catabolic process The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. BP
GO:0003704 specific RNA polymerase II transcription factor activity Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II. MF
GO:0003705 RNA polymerase II transcription factor activity, enhancer binding Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA. MF
GO:0006550 isoleucine catabolic process The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. BP
GO:0003707 steroid hormone receptor activity Combining with a steroid hormone to initiate a change in cell activity. MF
GO:0008851 ethanolamine ammonia-lyase activity Catalysis of the reaction: ethanolamine = acetaldehyde + NH3. MF
GO:0006874 calcium ion homeostasis The regulation of the levels, transport, and metabolism of calcium ions within a cell or between a cell and its external environment. BP
GO:0006877 cobalt ion homeostasis The regulation of the levels, transport, and metabolism of cobalt ions within a cell or between a cell and its external environment. BP
GO:0006876 cadmium ion homeostasis The regulation of the levels, transport, and metabolism of cadmium ions within a cell or between a cell and its external environment. BP
GO:0003803 coagulation factor IXa activity Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa. MF
GO:0003802 coagulation factor VIIa activity Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta. MF
GO:0031608 ER proteasome core complex, beta-subunit complex The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell. CC
GO:0031609 cytosolic proteasome core complex, beta-subunit complex (sensu Eukaryota) The subunits forming the inner ring of the core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0006873 cell ion homeostasis The regulation of the levels, transport, and metabolism of ions within a cell or between a cell and its external environment. BP
GO:0031600 cytosolic proteasome regulatory particle (sensu Eukaryota) The regulatory subcomplex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0031601 nuclear proteasome core complex The core complex of a proteasome located in the nucleus of a cell. CC
GO:0031602 ER proteasome core complex The core complex of a proteasome located in the endoplasmic reticulum of a cell. CC
GO:0031603 cytosolic proteasome core complex (sensu Eukaryota) The core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0031604 nuclear proteasome core complex, alpha-subunit complex The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell. CC
GO:0031605 ER proteasome core complex, alpha-subunit complex The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell. CC
GO:0031606 cytosolic proteasome core complex, alpha-subunit complex (sensu Eukaryota) The subunits forming the outer ring of the core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0031607 nuclear proteasome core complex, beta-subunit complex The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell. CC
GO:0002828 regulation of T-helper 2 type immune response Any process that modulates the frequency, rate, or extent of a T-helper 2 type immune response. BP
GO:0002829 negative regulation of T-helper 2 type immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 2 type immune response. BP
GO:0002826 negative regulation of T-helper 1 type immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response. BP
GO:0002827 positive regulation of T-helper 1 type immune response Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. BP
GO:0002824 positive regulation of adaptive immune response (sensu Gnathostomata) Any process that activates or increases the frequency, rate, or extent of an adaptive immune response, as in, but not restricted to, the jawed vertebrates (Gnathostomata, ncbi_taxonomy_id:7776). BP
GO:0002825 regulation of T-helper 1 type immune response Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. BP
GO:0002822 regulation of adaptive immune response (sensu Gnathostomata) Any process that modulates the frequency, rate, or extent of an adaptive immune response, as in, but not restricted to, the jawed vertebrates (Gnathostomata, ncbi_taxonomy_id:7776). BP
GO:0002823 negative regulation of adaptive immune response (sensu Gnathostomata) Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response , as in, but not restricted to, the jawed vertebrates (Gnathostomata, ncbi_taxonomy_id:7776). BP
GO:0002820 negative regulation of adaptive immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. BP
GO:0002821 positive regulation of adaptive immune response Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. BP
GO:0009768 photosynthesis, light harvesting in photosystem I After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. BP
GO:0009769 photosynthesis, light harvesting in photosystem II After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. BP
GO:0009760 C4 photosynthesis The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch. BP
GO:0009761 CAM photosynthesis The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis. BP
GO:0009762 NADP-malic enzyme C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme. BP
GO:0009763 NAD-malic enzyme C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme. BP
GO:0009764 PEP carboxykinase C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK). BP
GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. BP
GO:0009766 primary charge separation In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes. BP
GO:0009767 photosynthetic electron transport The process by which pairs of electrons are transported from water to NADP+ in the light phase of photosynthesis during noncyclic photophosphorylation. BP
GO:0031051 scnRNA production Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome. BP
GO:0031050 dsRNA fragmentation Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. BP
GO:0031053 primary microRNA processing Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. BP
GO:0031052 chromosome breakage Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage. BP
GO:0031055 chromatin remodeling at centromere Dynamic structural changes in centromeric DNA. BP
GO:0031054 pre-microRNA processing Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. BP
GO:0031057 negative regulation of histone modification Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of a histone. BP
GO:0031056 regulation of histone modification Any process that modulates the frequency, rate or extent of the covalent alteration of a histone. BP
GO:0008419 RNA lariat debranching enzyme activity NA MF
GO:0008418 protein N-terminal asparagine amidohydrolase activity NA MF
GO:0008411 4-hydroxybutyrate CoA-transferase activity Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate. MF
GO:0008410 CoA-transferase activity Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). MF
GO:0008413 8-oxo-7,8-dihydroguanine triphosphatase activity Catalysis of the reaction: 8-oxo-7,8-dihydroguanine triphosphate = 8-oxo-7,8-dihydroguanine phosphate + diphosphate. MF
GO:0008412 4-hydroxybenzoate octaprenyltransferase activity Catalysis of the reaction: farnesylfarnesylgeranyl-PP + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate. MF
GO:0008415 acyltransferase activity Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. MF
GO:0008414 CDP-alcohol phosphotransferase activity Catalysis of the transfer of a CDP-alcohol group from one compound to another. MF
GO:0008417 fucosyltransferase activity Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. MF
GO:0008416 delta5-delta2,4-dienoyl-CoA isomerase activity NA MF
GO:0021659 rhombomere 3 structural organization The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0042174 negative regulation of sporulation Any process that stops, prevents or reduces the frequency, rate or extent of sporulation. BP
GO:0042175 nuclear envelope-endoplasmic reticulum network The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum. CC
GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. BP
GO:0042177 negative regulation of protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. BP
GO:0042170 plastid membrane Either of the lipid bilayers that surround a plastid and form the plastid envelope. CC
GO:0042171 lysophosphatidic acid acyltransferase activity NA MF
GO:0042173 regulation of sporulation Any process that modulates the frequency, rate or extent of spore formation. BP
GO:0042178 xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. BP
GO:0042179 nicotine biosynthetic process The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. BP
GO:0045746 negative regulation of Notch signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the Notch signaling pathway. BP
GO:0045747 positive regulation of Notch signaling pathway Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. BP
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. BP
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. BP
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. BP
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. BP
GO:0045740 positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication. BP
GO:0045741 positive regulation of epidermal growth factor receptor activity Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor activity. BP
GO:0021655 rhombomere 2 morphogenesis The process by which the anatomical structure of rhombomere 2 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0045748 positive regulation of R8 spacing Any process that activates or enforces the correct R8 spacing. BP
GO:0045749 negative regulation of S phase of mitotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity. BP
GO:0047678 arginine 2-monooxygenase activity Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O. MF
GO:0047679 arginine racemase activity Catalysis of the reaction: L-arginine = D-arginine. MF
GO:0042288 MHC class I protein binding Interacting selectively with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. MF
GO:0042289 MHC class II protein binding Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. MF
GO:0047670 anhydrotetracycline monooxygenase activity Catalysis of the reaction: anhydrotetracycline + NADPH + O2 = 12-dehydrotetracycline + NADP+ + H2O. MF
GO:0047671 anthranilate adenylyltransferase activity Catalysis of the reaction: ATP + anthranilate = diphosphate + N-adenylylanthranilate. MF
GO:0047672 anthranilate N-benzoyltransferase activity Catalysis of the reaction: benzoyl-CoA + anthranilate = CoA + N-benzoylanthranilate. MF
GO:0047673 anthranilate N-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + anthranilate = CoA + N-malonylanthranilate. MF
GO:0047674 apiose 1-reductase activity Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + NADH. MF
GO:0047675 arabinonate dehydratase activity Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O. MF
GO:0047676 arachidonate-CoA ligase activity Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA. MF
GO:0047677 arachidonate 8-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. MF
GO:0030922 peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. BP
GO:0030923 metal incorporation into metallo-oxygen cluster The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate. BP
GO:0030920 peptidyl-serine acetylation The acetylation of peptidyl-serine. BP
GO:0030921 peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. BP
GO:0030926 calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. BP
GO:0030927 manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. BP
GO:0030924 manganese incorporation into metallo-oxygen cluster The incorporation of manganese into a metallo-oxygen cluster. BP
GO:0030925 calcium incorporation into metallo-oxygen cluster The incorporation of calcium into a metallo-oxygen cluster. BP
GO:0030928 dopachrome decarboxylase activity Catalysis of the decarboxylation of L-dopachrome to form 5,6-dihydroxyindole. MF
GO:0030929 ADPG pyrophosphorylase complex Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits. CC
GO:0050902 leukocyte adhesive activation The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation. BP
GO:0050903 leukocyte activation-dependent arrest The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation. BP
GO:0050900 leukocyte migration The movement of leukocytes within or between different tissues and organs of the body. BP
GO:0050901 leukocyte tethering or rolling Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation. BP
GO:0050906 detection of stimulus during sensory perception The series of events during sensory perception in which a sensory stimulus is received by a cell and converted into a molecular signal. BP
GO:0050907 detection of chemical stimulus during sensory perception The series of events in which a sensory chemical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050904 diapedesis The passage of leukocytes between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. BP
GO:0050905 neuromuscular process The processes pertaining to the functions of the nervous and muscular systems of an organism. BP
GO:0050908 detection of light stimulus during visual perception The series of events during visual perception in which a sensory light stimulus is received by a cell and converted into a molecular signal. BP
GO:0050909 sensory perception of taste The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. BP
GO:0046109 uridine biosynthetic process The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. BP
GO:0046108 uridine metabolic process The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. BP
GO:0046101 hypoxanthine biosynthetic process The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. BP
GO:0046100 hypoxanthine metabolic process The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. BP
GO:0046103 inosine biosynthetic process The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. BP
GO:0046102 inosine metabolic process The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. BP
GO:0046105 thymidine biosynthetic process The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. BP
GO:0046104 thymidine metabolic process The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. BP
GO:0046107 uracil biosynthetic process The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. BP
GO:0046106 thymine biosynthetic process The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. BP
GO:0048859 formation of anatomical boundary The process by which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. BP
GO:0048858 cell projection morphogenesis The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0002019 angiotensin mediated regulation of renal output The process by which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney. BP
GO:0002018 renin-angiotensin regulation of aldosterone production The process by which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. BP
GO:0048855 adenohypophysis morphogenesis The process by which the anatomical structures of the adenohypophysis are generated and organized. Morphogenesis pertains to the creation of form. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. BP
GO:0035195 miRNA-mediated gene silencing Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. BP
GO:0002015 atrial regulation of blood pressure Processes that control blood pressure by sensing the amount of stretch occurring in the atria. BP
GO:0035197 siRNA binding Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. MF
GO:0002013 detection of carbon dioxide by vasomotor center The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system. BP
GO:0035191 nuclear axial expansion The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex. BP
GO:0048853 forebrain morphogenesis The process by which the anatomical structures of the forebrain are generated and organized. Morphogenesis pertains to the creation of form. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). BP
GO:0035193 central nervous system remodeling (sensu Insecta) Reorganization of the preexisting, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048279 vesicle fusion with endoplasmic reticulum The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum. BP
GO:0048278 vesicle docking The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. BP
GO:0048270 methionine adenosyltransferase regulator activity Modulates the activity of methionine adenosyltransferase. MF
GO:0048273 mitogen-activated protein kinase p38 binding Interacting selectively with mitogen-activated protein kinase p38, an enzyme that catalyses the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. MF
GO:0048275 N-terminal peptidyl-arginine acetylation The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase. BP
GO:0048276 gastrulation (sensu Vertebrata) The process of gastrulation, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0004312 fatty-acid synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. MF
GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. MF
GO:0004310 farnesyl-diphosphate farnesyltransferase activity Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. MF
GO:0004311 farnesyltranstransferase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. MF
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. MF
GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. MF
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. MF
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. MF
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. MF
GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+. MF
GO:0052430 modulation by host of symbiont RNA levels The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052433 modulation by organism of apoptosis in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052435 modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway Any process by which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0018439 peptidyl-leucine esterification The chemical reactions and pathways resulting in the formation of peptidyl-L-leucine methyl ester. BP
GO:0003836 beta-galactoside alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R. MF
GO:0006805 xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. BP
GO:0003834 beta-carotene 15,15'-monooxygenase activity Catalysis of the reaction: beta-carotene + O2 = 2 retinal. MF
GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. BP
GO:0006800 oxygen and reactive oxygen species metabolic process The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH). BP
GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. BP
GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. MF
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide. MF
GO:0006808 regulation of nitrogen utilization Any process that modulates the frequency, rate or extent of nitrogen utilization. BP
GO:0006809 nitric oxide biosynthetic process The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. BP
GO:0003838 sterol 24-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. MF
GO:0003839 gamma-glutamylcyclotransferase activity Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. MF
GO:0019527 pentitol catabolic process The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule. BP
GO:0019526 pentitol biosynthetic process The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule. BP
GO:0019525 D-dehydro-D-gluconate metabolic process The chemical reactions and pathways involving D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose. BP
GO:0019524 D-dehydro-D-gluconate catabolic process The chemical reactions and pathways resulting in the breakdown of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose. BP
GO:0019523 L-idonate metabolic process The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. BP
GO:0019522 ketogluconate metabolic process The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. BP
GO:0019521 D-gluconate metabolic process The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. BP
GO:0019520 aldonic acid metabolic process The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. BP
GO:0019529 taurine catabolic process The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. BP
GO:0019528 D-arabitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate. BP
GO:0042905 9-cis-retinoic acid metabolic process The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative. BP
GO:0042904 9-cis-retinoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. BP
GO:0042907 xanthine transporter activity Enables the directed movement of xanthine, into, out of, within or between cells. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. MF
GO:0042906 xanthine transport The directed movement of xanthine into, out of, within or between cells. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. BP
GO:0042901 arabinose polymer transporter activity Enables the directed movement of an arabinose polymer, a repeating chain of arabinose monomers, into, out of, within or between cells. MF
GO:0042900 arabinose transporter activity Enables the directed movement of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, into, out of, within or between cells. MF
GO:0042903 tubulin deacetylase activity Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. MF
GO:0042902 peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. BP
GO:0002498 proteolysis within endoplasmic reticulum associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation. BP
GO:0042909 acridine transport The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of, within or between cells. BP
GO:0042908 xenobiotic transport The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells. BP
GO:0050289 spermidine dehydrogenase activity Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor. MF
GO:0050288 sorbose dehydrogenase activity Catalysis of the reaction: L-sorbose + acceptor = 5-dehydro-D-fructose + reduced acceptor. MF
GO:0050281 serine-glyoxylate transaminase activity Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine. MF
GO:0050280 sequoyitol dehydrogenase activity Catalysis of the reaction: 5-O-methyl-myo-inositol + NAD+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH. MF
GO:0050283 serine-sulfate ammonia-lyase activity Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + SO4(2-) (sulfate). MF
GO:0050282 serine 2-dehydrogenase activity Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH. MF
GO:0050285 sinapine esterase activity Catalysis of the reaction: sinapoylcholine + H2O = sinapate + choline. MF
GO:0050284 sinapate 1-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose. MF
GO:0050287 sorbose 5-dehydrogenase (NADP+) activity Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + NADPH. MF
GO:0050286 sorbitol-6-phosphatase activity Catalysis of the reaction: sorbitol 6-phosphate + H2O = sorbitol + phosphate. MF
GO:0019383 (+)-camphor catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone. BP
GO:0019382 carbon tetrachloride catabolic process The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. BP
GO:0019381 atrazine catabolic process The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide. BP
GO:0019380 3-phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid. BP
GO:0019387 methanogenesis, from methanol The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol. BP
GO:0019386 methanogenesis, from carbon dioxide The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2). BP
GO:0019385 methanogenesis, from acetate The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate. BP
GO:0019384 caprolactam catabolic process The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid. BP
GO:0019389 glucuronoside metabolic process The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate. BP
GO:0019388 galactose catabolic process The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose. BP
GO:0050133 N6-hydroxylysine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N6-hydroxy-L-lysine = CoA + N6-acetyl-N6-hydroxy-L-lysine. MF
GO:0050132 N-methylalanine dehydrogenase activity Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = pyruvate + methylamine + NADPH. MF
GO:0050131 N-methyl-L-amino-acid oxidase activity Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2. MF
GO:0050130 N-methyl-2-oxoglutaramate hydrolase activity Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine. MF
GO:0050137 NADPH peroxidase activity Catalysis of the reaction: NADPH + H2O2 = NADP+ + 2 H2O. MF
GO:0050136 NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. MF
GO:0050135 NAD(P)+ nucleosidase activity Catalysis of the reaction: NAD(P)+ + H2O = ADPribose(P) + nicotinamide. MF
GO:0050134 N6-methyl-lysine oxidase activity Catalysis of the reaction: N6-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2. MF
GO:0050139 nicotinate glucosyltransferase activity Catalysis of the reaction: UDP-glucose + nicotinate = UDP + N-glucosylnicotinate. MF
GO:0050138 nicotinate dehydrogenase activity Catalysis of the reaction: nicotinate + H2O + NADP+ = 6-hydroxynicotinate + NADPH. MF
GO:0050169 peptide-tryptophan 2,3-dioxygenase activity Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine. MF
GO:0005869 dynactin complex A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. CC
GO:0005868 cytoplasmic dynein complex Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains. CC
GO:0051426 spindle pole body maturation The processes by which the newly duplicated spindle pole body (SPB) is processed to attain its full functional capacity. In S. pombe, early maturation includes increase in size of the lamellar bodies, invagination of the nuclear envelope, and accumulation of material in a pocket under the SPB. Late maturation includes fenestration of the nuclear envelope, SPB separation and entry into the nucleus, giving rise to the spindle. BP
GO:0051427 hormone receptor binding Interacting selectively with a receptor for hormones. MF
GO:0051424 corticotropin-releasing hormone binding Interacting selectively with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. MF
GO:0051425 PTB domain binding Interacting selectively with a phosphotyrosine-binding (PTB) domain of a protein. MF
GO:0005863 striated muscle thick filament Filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils. CC
GO:0005862 muscle thin filament tropomyosin An isoform of tropomyosin found associated with actin and the troponin complex in muscle thin filaments. CC
GO:0051420 nebulette binding Interacting selectively with nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin. MF
GO:0051421 regulation of endo-1,4-beta-xylanase activity Any process that modulates the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans. BP
GO:0007032 endosome organization and biogenesis The assembly and arrangement of endosomes. BP
GO:0007033 vacuole organization and biogenesis The assembly and arrangement of a vacuole. BP
GO:0007030 Golgi organization and biogenesis The assembly and arrangement of the Golgi apparatus. BP
GO:0007031 peroxisome organization and biogenesis The assembly and arrangement of a peroxisome. BP
GO:0007036 vacuolar calcium ion homeostasis The regulation of the levels, transport, and metabolism of calcium ions in the vacuole or between a vacuole and its surroundings. BP
GO:0007037 vacuolar phosphate transport The directed movement of phosphates into, out of or within a vacuole. BP
GO:0007034 vacuolar transport The directed movement of substances into, out of or within a vacuole. BP
GO:0007035 vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. BP
GO:0007038 endocytosed protein transport to vacuole The directed movement of proteins imported into a cell by endocytosis to the vacuole. BP
GO:0007039 vacuolar protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. BP
GO:0050165 pantetheine kinase activity Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate. MF
GO:0052199 negative regulation of enzyme activity in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052198 modification of protease activity in other organism during symbiotic interaction The process by which an organism effects a change in protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052197 positive regulation by host of symbiont defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052196 negative regulation by host of symbiont defense response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052195 movement on or near other organism during symbiotic interaction The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052194 movement on or near symbiont The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052193 movement in symbiont environment The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052192 movement in environment of other organism during symbiotic interaction The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052191 positive regulation by symbiont of host phagocytosis Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052190 modulation by symbiont of host phagocytosis Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans. BP
GO:0006074 1,3-beta-glucan metabolic process The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. BP
GO:0006077 1,6-beta-glucan metabolic process The chemical reactions and pathways involving beta-1,6 glucans, compounds composed of glucose residues linked by 1,6-beta-D-glucosidic bonds. BP
GO:0006076 1,3-beta-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of beta-1,3 glucans. BP
GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. BP
GO:0006070 octanol metabolic process The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH. BP
GO:0006073 glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. BP
GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. BP
GO:0006079 1,6-beta-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of beta-1,6 glucans. BP
GO:0006078 1,6-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,6 glucans. BP
GO:0010249 auxin conjugate metabolic process The chemical reactions and pathways involving auxin conjugates, a bound form of free auxin. BP
GO:0010248 establishment and/or maintenance of transmembrane electrochemical gradient The directed movement of ions to establish and maintain an electrochemical gradient across a membrane. BP
GO:0010241 ent-kaurene oxidase activity Catalysis of three successive oxidations of the 4-methyl group of ent-kaurene resulting in kaurenoic acid. MF
GO:0010240 pyruvate dehydrogenase complex (sensu Viridiplantae) Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0010243 response to organic nitrogen A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. Organic nitrogen is contained as amines in organic compounds such as amino acids and proteins. BP
GO:0010242 oxygen evolving activity The evolution of oxygen from oxidizing water carried out by oxygen evolving complex in photosystem II of plants. MF
GO:0010245 radial microtubular system formation Formation of radial microtubular systems during male meiotic cytokinesis in plants. BP
GO:0010244 response to low fluence blue light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence blue light stimulus. Low fluence blue light is blue light (threshold 0.1 mmol/m2/sec); excitation of the Blue Low Fluence (BLF)-System induces the transcription of a number of nuclear and plastid coded genes. BP
GO:0010247 detection of phosphate ion The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal. BP
GO:0010246 rhamnogalacturonan I biosynthetic process The chemical reactions and pathways resulting in the formation of rhamonogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide. BP
GO:0051414 response to cortisol stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions. BP
GO:0001410 chlamydospore formation (sensu Candida albicans) Development of chlamydospores, which are thick-walled, spore-like cells borne on the ends of elongated cells attached to hyphae or pseudohyphae, seen in the species Candida albicans and Candida dubliniensis. Note that although these structures resemble the chlamydospores of other fungi, it is not known whether they are true spores, so this process is not currently considered an instance of spore formation. As in, but not restricted to, the taxon Candida albicans (Candida albicans, ncbi_taxonomy_id:5476). BP
GO:0001411 hyphal tip The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation. CC
GO:0005528 FK506 binding Interacting selectively with the immunosuppressant FK506. MF
GO:0005529 sugar binding Interacting selectively with any mono-, di- or trisaccharide carbohydrate. MF
GO:0051419 nebulin binding Interacting selectively with nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone. MF
GO:0005522 profilin binding Interacting selectively with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. MF
GO:0005523 tropomyosin binding Interacting selectively with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. MF
GO:0005520 insulin-like growth factor binding Interacting selectively with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. MF
GO:0005521 lamin binding Interacting selectively with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. MF
GO:0005527 macrolide binding Interacting selectively with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. MF
GO:0005524 ATP binding Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. MF
GO:0005525 GTP binding Interacting selectively with GTP, guanosine triphosphate. MF
GO:0015598 arginine-importing ATPase activity Catalysis of the reaction: ATP + H2O + arginine(out) = ADP + phosphate + arginine(in). MF
GO:0015599 glutamine-importing ATPase activity Catalysis of the reaction: ATP + H2O + glutamine(out) = ADP + phosphate + glutamine(in). MF
GO:0015592 methylgalactoside transporter activity Enables the directed movement of methylgalactoside into, out of, within or between cells. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. MF
GO:0015593 allose transporter activity Enables the directed movement of allose into, out of, within or between cells. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. MF
GO:0015590 N-acetylgalactosamine permease activity NA MF
GO:0015591 D-ribose transporter activity Enables the directed movement of D-ribose into, out of, within or between cells. As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. MF
GO:0015594 putrescine-importing ATPase activity Catalysis of the reaction: ATP + H2O + putrescine(out) = ADP + phosphate + putrescine(in). MF
GO:0015595 spermidine-importing ATPase activity Catalysis of the reaction: ATP + H2O + spermidine(out) = ADP + phosphate + spermidine(in). MF
GO:0015628 protein secretion by the type II secretion system The process by which proteins are secreted across the outer membrane by the type II secretion system. Proteins using this pathway are first translocated across the plasma membrane via the Sec (general secretory) or Tat pathways. BP
GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. CC
GO:0047478 aspartate-ammonia ligase (ADP-forming) activity Catalysis of the reaction: NH3 + L-aspartate + ATP = phosphate + L-asparagine + ADP. MF
GO:0047479 trypanothione synthase activity Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate. MF
GO:0047476 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + pyrophosphate + AMP. MF
GO:0047477 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity Catalysis of the reaction: CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA + pyrophosphate + AMP. MF
GO:0015626 L-diaminopimelate transporter activity Enables the directed movement of L-diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of, within or between cells. MF
GO:0015627 type II protein secretion system complex NA CC
GO:0047472 3-carboxy-cis,cis-muconate cycloisomerase activity Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate. MF
GO:0047473 D-alanine-poly(phosphoribitol) ligase activity Catalysis of the reaction: poly(ribitol phosphate) + D-alanine + ATP = O-D-alanyl-poly(ribitol phosphate) + pyrophosphate + AMP. MF
GO:0047470 (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity Catalysis of the reaction: 4-(1,4-alpha-D-glucosyl)(n-1)-D-glucose = 1-alpha-D-(1,4-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside. MF
GO:0047471 maltose alpha-D-glucosyltransferase activity Catalysis of the reaction: maltose = trehalose. MF
GO:0043508 negative regulation of JNK activity Any process that stops, prevents or reduces the frequency, rate or extent of JUN kinase activity. BP
GO:0043509 activin A complex A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A). CC
GO:0043506 regulation of JNK activity Any process that modulates the frequency, rate or extent of JUN kinase activity. BP
GO:0043507 positive regulation of JNK activity Any process that activates or increases the frequency, rate or extent of JUN kinase activity. BP
GO:0043504 mitochondrial DNA repair The process of restoring mitochondrial DNA after damage. BP
GO:0043505 centromere-specific nucleosome A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). CC
GO:0043502 regulation of muscle plasticity Any process that modulates the frequency, rate or extent of muscle plasticity. BP
GO:0043503 skeletal muscle fiber plasticity Processes by which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. BP
GO:0043500 muscle plasticity Processes by which muscle adapts to stimuli such as contractile activity, loading conditions, substrate supply, and enviromental factors. These adaptive structural events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. BP
GO:0043501 skeletal muscle plasticity Processes by which skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. BP
GO:0045830 positive regulation of isotype switching Any process that activates or increases the frequency, rate or extent of isotype switching. BP
GO:0045831 negative regulation of light-activated channel activity Any process that stops, prevents or reduces the frequency, rate or extent of light-activated channel activity. BP
GO:0045832 positive regulation of light-activated channel activity Any process that activates or increases the frequency, rate or extent of light-activated channel activity. BP
GO:0045833 negative regulation of lipid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. BP
GO:0045834 positive regulation of lipid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. BP
GO:0045835 negative regulation of meiosis Any process that stops, prevents or reduces the frequency, rate or extent of meiosis. BP
GO:0045836 positive regulation of meiosis Any process that activates or increases the frequency, rate or extent of meiosis. BP
GO:0045837 negative regulation of membrane potential Any process that stops, prevents or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. BP
GO:0045838 positive regulation of membrane potential Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. BP
GO:0045839 negative regulation of mitosis Any process that stops, prevents or reduces the frequency, rate or extent of mitosis. BP
GO:0018498 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate. MF
GO:0030768 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxy-tabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline. MF
GO:0030769 macrocin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin. MF
GO:0030760 pyridine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + pyridine = S-adenosyl-L-homocysteine + N-methylpyridinium. MF
GO:0030761 8-hydroxyquercitin 8-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxy-flavone. MF
GO:0030762 tetrahydrocolumbamine 2-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine. MF
GO:0030763 isobutyraldoxime O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-methylpropanal oxime = S-adenosyl-L-homocysteine + 2-methylpropanal O-methyloxime. MF
GO:0030764 bergaptol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + bergaptol = S-adenosyl-L-homocysteine + O-methylbergaptol. MF
GO:0030765 xanthotoxol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + O-methylxanthotoxol. MF
GO:0030766 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline. MF
GO:0030767 3-hydroxyanthranilate 4-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-hydroxyanthranilate = S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate. MF
GO:0018497 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS. MF
GO:0043616 keratinocyte proliferation The multiplication or reproduction of keratinocytes, resulting in the rapid expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. BP
GO:0008627 induction of apoptosis by ionic changes NA BP
GO:0043614 multi-eIF complex A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preintiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. CC
GO:0043615 astrocyte cell migration The orderly movement of astrocytes, class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord. BP
GO:0043612 isoprene biosynthetic process The chemical reactions and pathways resulting in the formation of isoprene, C5H8. BP
GO:0043613 isoprene catabolic process The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8. BP
GO:0045167 asymmetric protein localization during cell fate commitment The processes by which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types. BP
GO:0045165 cell fate commitment The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. BP
GO:0045162 clustering of voltage-gated sodium channels The process by which voltage gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization. BP
GO:0045163 clustering of voltage-gated potassium channels The process by which voltage gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode. BP
GO:0045160 myosin I complex A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement. CC
GO:0045161 neuronal ion channel clustering The process by which voltage-gated sodium and potassium ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. BP
GO:0045168 cell-cell signaling during cell fate commitment Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. BP
GO:0045169 fusome A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle. CC
GO:0047995 hydroxyphenylpyruvate reductase activity Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH. MF
GO:0047994 hydroxymethylglutaryl-CoA hydrolase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate. MF
GO:0047997 hydroxypyruvate decarboxylase activity Catalysis of the reaction: hydroxypyruvate = glycolaldehyde + CO2. MF
GO:0047996 hydroxyphytanate oxidase activity Catalysis of the reaction: L-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2. MF
GO:0047991 hydroxylamine oxidase activity Catalysis of the reaction: hydroxylamine + O2 = NO2(-) (nitrite) + H2O. MF
GO:0047990 hydroxyglutamate decarboxylase activity Catalysis of the reaction: 3-hydroxy-L-glutamate = 4-amino-3-hydroxybutanoate + CO2. MF
GO:0047993 hydroxymalonate dehydrogenase activity Catalysis of the reaction: hydroxymalonate + NAD+ = oxomalonate + NADH. MF
GO:0047992 hydroxylysine kinase activity Catalysis of the reaction: GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine. MF
GO:0047999 hyponitrite reductase activity Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = hyponitrous acid + 2 NADH + 2 H+. MF
GO:0047998 hyoscyamine (6S)-dioxygenase activity Catalysis of the reaction: L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2. MF
GO:0008338 MAP kinase 1 activity NA MF
GO:0008339 MP kinase activity NA MF
GO:0008330 protein tyrosine/threonine phosphatase activity NA MF
GO:0008331 high voltage-gated calcium channel activity NA MF
GO:0008332 low voltage-gated calcium channel activity NA MF
GO:0008333 endosome to lysosome transport The directed movement of substances from endosomes to lysosomes. BP
GO:0008334 histone mRNA metabolic process The chemical reactions and pathways involving an mRNA encoding a histone. BP
GO:0008335 ovarian ring canal stabilization Maintenance of the structural integrity of the ring canals connecting the female germ-line cyst. BP
GO:0008336 gamma-butyrobetaine dioxygenase activity Catalysis of the reaction: 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2. MF
GO:0008628 induction of apoptosis by hormones Any process induced by hormones that directly activates any of the steps required for cell death by apoptosis. BP
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress Modulation of the frequency, rate or extent of transcription from an from RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. BP
GO:0031419 cobalamin binding Interacting lelectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. MF
GO:0031418 L-ascorbic acid binding Interacting selectivzely with L-ascorbic acid, a six-carbon carbohydrate-like compound found in fruit and vegetables. It has vitamin C activity in humans and guinea pigs. MF
GO:0031411 gas vesicle A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations. CC
GO:0031410 cytoplasmic vesicle A vesicle formed of membrane or protein, found in the cytoplasm of a cell. CC
GO:0031413 regulation of buoyancy Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases. BP
GO:0031412 gas vesicle organization and biogenesis The assembly and arrangement of a gas vesicle. BP
GO:0031415 NatA complex A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins. CC
GO:0031414 N-terminal protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. CC
GO:0031417 NatC complex A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p. CC
GO:0031416 NatB complex A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p. CC
GO:0047898 formate dehydrogenase (cytochrome) activity Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1. MF
GO:0047899 formate dehydrogenase (NADP+) activity Catalysis of the reaction: formate + NADP+ = CO2 + NADPH. MF
GO:0032269 negative regulation of cellular protein metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. BP
GO:0032268 regulation of cellular protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. BP
GO:0032263 GMP salvage Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis. BP
GO:0032262 pyrimidine nucleotide salvage Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis. BP
GO:0032261 purine nucleotide salvage Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis. BP
GO:0032260 response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. BP
GO:0032267 tRNA(Ile)-lysidine synthase Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine. MF
GO:0032266 phosphatidylinositol 3-phosphate binding Interacting selectively with phosphatidylinositol 3-phosphate, a phosphorylated derivative of phosphatidylinositol. MF
GO:0032265 XMP salvage Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis. BP
GO:0032264 IMP salvage Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. BP
GO:0047894 flavonol 3-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate. MF
GO:0047895 formaldehyde dismutase activity Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate. MF
GO:0032199 transcription during RNA-mediated transposition The synthesis of DNA from an RNA transposon intermediate. BP
GO:0032198 MITE transposition Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs). BP
GO:0044236 multicellular organismal metabolic process The chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. BP
GO:0032195 post-lysosomal vacuole A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. CC
GO:0032194 ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate. BP
GO:0032197 transposition, RNA-mediated Any process involved in a type of transpositional recombination which occurs via an RNA intermediate. BP
GO:0032196 transposition Any process involved in mediating the movement of discrete segments of DNA between nonhomolgous sites. BP
GO:0032191 acrosin heavy chain binding Interacting selectively with the larger of the two covalently linked polypeptide chains of acrosin. MF
GO:0032190 acrosin binding Interacting selectively with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. MF
GO:0032193 ubiquinone biosynthetic process via 2-polyprenylphenol The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol. BP
GO:0032192 acrosin light chain binding Interacting selectively with the smaller of the two covalently linked polypeptide chains of acrosin. MF
GO:0052145 negative energy taxis on or near host The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052143 chemotaxis on or near host The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0005308 creatine transporter activity Enables the directed movement of creatine into, out of, within or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. MF
GO:0005306 choline permease activity NA MF
GO:0005307 choline:sodium symporter activity Catalysis of the reaction: choline(out) + Na+(out) = choline(in) + Na+(in). MF
GO:0042325 regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphoric groups into a molecule. BP
GO:0042324 hypocretin receptor binding Interacting selectively with the hypocretin receptor. MF
GO:0006279 premeiotic DNA synthesis The replication of DNA that precedes meiotic cell division. BP
GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. BP
GO:0042321 negative regulation of circadian sleep/wake cycle, sleep Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. BP
GO:0042320 regulation of circadian sleep/wake cycle, REM sleep Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep. BP
GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. BP
GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep. BP
GO:0006273 lagging strand elongation The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. BP
GO:0006272 leading strand elongation The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork. BP
GO:0006271 DNA strand elongation during DNA replication The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. BP
GO:0006270 DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. BP
GO:0042329 structural constituent of cuticle (sensu Nematoda) The action of a molecule that contributes to the structural integrity of a cuticle. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). MF
GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. MF
GO:0006275 regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. BP
GO:0006274 DNA replication termination The process by which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. BP
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. MF
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm. CC
GO:0000305 response to oxygen radical A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. BP
GO:0000304 response to singlet oxygen A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. BP
GO:0000307 cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. CC
GO:0000306 extrinsic to vacuolar membrane Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region. CC
GO:0000301 retrograde transport, vesicle recycling within Golgi The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. BP
GO:0000300 peripheral to membrane of membrane fraction Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH. CC
GO:0000303 response to superoxide A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. BP
GO:0000302 response to reactive oxygen species A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. BP
GO:0050713 negative regulation of interleukin-1 beta secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells. BP
GO:0050712 negative regulation of interleukin-1 alpha secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells. BP
GO:0050711 negative regulation of interleukin-1 secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells. BP
GO:0050710 negative regulation of cytokine secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells. BP
GO:0050717 positive regulation of interleukin-1 alpha secretion Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells. BP
GO:0050716 positive regulation of interleukin-1 secretion Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells. BP
GO:0050715 positive regulation of cytokine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells. BP
GO:0050714 positive regulation of protein secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a protein from a cell or group of cells. BP
GO:0050719 interleukin-1 alpha biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-1 alpha. BP
GO:0050718 positive regulation of interleukin-1 beta secretion Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells. BP
GO:0002228 natural killer cell mediated immunity The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. BP
GO:0002229 defense response to oomycetes Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism. BP
GO:0002224 toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. BP
GO:0002225 positive regulation of antimicrobial peptide production Any process that activates or increases the frequency, rate, or extent of . BP
GO:0002226 innate immune response (sensu Viridiplantae) The process of the innate immunity as in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). Innate immune responses are defense responses mediated by germline encoded components that, in plants, directly recognize components of potential pathogens. BP
GO:0002227 innate immune response in mucosa Any process of the innate immune response that takes place in the mucosal tissues. BP
GO:0002220 innate immune response activating cell surface receptor signaling pathway Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. BP
GO:0002221 pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. BP
GO:0002222 stimulatory killer cell immunoglobulin-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation. BP
GO:0002223 stimulatory C-type lectin receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation. BP
GO:0051390 inactivation of MAPKKK activity Any process that terminates the activity of the active enzyme MAP kinase kinase kinase. BP
GO:0051391 tRNA acetylation The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. BP
GO:0051392 tRNA N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA. MF
GO:0051393 alpha-actinin binding Interacting selectively with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. MF
GO:0051394 regulation of nerve growth factor receptor activity Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor. BP
GO:0051395 negative regulation of nerve growth factor receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor. BP
GO:0051396 positive regulation of nerve growth factor receptor activity Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor. BP
GO:0051397 N-terminal basic amino acid aminopeptidase activity Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain. MF
GO:0051398 N-terminal lysine aminopeptidase activity Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain. MF
GO:0051399 N-terminal arginine aminopeptidase activity Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain. MF
GO:0004109 coproporphyrinogen oxidase activity Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. MF
GO:0004108 citrate (Si)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. MF
GO:0001559 regulation of cell growth by detection of nuclear:cytoplasmic ratio Any process whereby the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. BP
GO:0001558 regulation of cell growth Any process that modulates the frequency, rate or extent of cell growth. BP
GO:0001553 luteinization Differentiation of theca and granulosa cells into luteal cells. Also other processes involved in the formation of a corpus luteum after ovulation. BP
GO:0001552 ovarian follicle atresia Ovarian follicle demise mediated by apoptosis. BP
GO:0001551 ovarian follicle endowment Association of oocytes with supporting epithelial granulosa cells to form primordial follicles. BP
GO:0001550 ovarian cumulus expansion Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells. BP
GO:0001556 oocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. BP
GO:0001555 oocyte growth The process by which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. BP
GO:0001554 luteolysis Regression of ovarian corpora lutea. BP
GO:0018085 peptidyl-L-amino acid racemization The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid. BP
GO:0018084 peptidyl-lactic acid biosynthetic process from peptidyl-serine The modification of N-terminal peptidyl-serine to lactic acid. BP
GO:0018083 peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine The posttranslational modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases. BP
GO:0018082 peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine The formation of (Z)-dehydrobutyrine by the posttranslational dehydration of peptidyl-threonine. BP
GO:0018081 peptide cross-linking via lanthionine or 3-methyl-lanthionine The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process. BP
GO:0018080 peptidyl-tryptophan bromination The posttranslational bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan. BP
GO:0001889 liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. BP
GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan. MF
GO:0001885 endothelial cell development The progression of an endothelial cell over time, from its formation to the mature structure. BP
GO:0001884 pyrimidine nucleoside binding Interacting selectively with pyrimidine nucleoside. MF
GO:0001887 selenium metabolic process The chemical reactions and pathways involving the nonmetallic element selenium or compounds that contain selenium, such as selenocysteine. BP
GO:0001886 endothelial cell morphogenesis The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. BP
GO:0001881 receptor recycling The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal. BP
GO:0001880 Mullerian duct regression The process by which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos. BP
GO:0001883 purine nucleoside binding Interacting selectively with a purine nucleoside. MF
GO:0001882 nucleoside binding Interacting selectively with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. MF
GO:0016737 oxidoreductase activity, acting on reduced flavodoxin as donor Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016732 oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen. MF
GO:0016731 oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. MF
GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016738 oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen. MF
GO:0021595 rhombomere structural organization The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. BP
GO:0021594 rhombomere formation The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. BP
GO:0021597 central nervous system structural organization The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. BP
GO:0021591 ventricular system development The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. BP
GO:0021590 cerebellum maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. BP
GO:0021593 rhombomere morphogenesis The process by which the anatomical structure of the rhombomere is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. BP
GO:0021592 fourth ventricle development The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space. BP
GO:0021599 abducens nerve formation The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. BP
GO:0021598 abducens nerve morphogenesis The process by which the anatomical structure of the abducens nerve is generated and organized. Morphogenesis pertains to the creation of form. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. BP
GO:0015918 sterol transport The directed movement of sterols into, out of, within or between cells. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. BP
GO:0015919 peroxisomal membrane transport The directed movement of substances to, from or across the peroxisomal membrane. BP
GO:0015916 fatty acyl coenzyme A transport The directed movement of fatty acyl coenzyme A into, out of, within or between cells. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A). BP
GO:0015917 aminophospholipid transport The directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. BP
GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. BP
GO:0015915 fatty acyl transport The directed movement of fatty acyl groups into, out of, within or between cells. A fatty acyl group is any acyl group derived from a fatty acid. BP
GO:0015912 short-chain fatty acid transport The directed movement of short-chain fatty acids into, out of, within or between cells. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons. BP
GO:0015913 short-chain fatty acid import The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons. BP
GO:0015910 peroxisomal long-chain fatty acid import The directed movement of long-chain fatty acids into a peroxisome. BP
GO:0015911 plasma membrane long-chain fatty acid transport The directed movement of long-chain fatty acids across the plasma membrane. BP
GO:0009564 male gametophyte formation The process that gives rise to the generative and vegetative cells. This process pertains to the initial formation of the structures from unspecified parts. The generative and vegetative cell make up the two-celled haploid microgametophyte phase of the flowering plant life cycle. BP
GO:0051973 positive regulation of telomerase activity Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). BP
GO:0008138 protein tyrosine/serine/threonine phosphatase activity NA MF
GO:0008139 nuclear localization sequence binding Interacting selectively with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. MF
GO:0008137 NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. MF
GO:0008134 transcription factor binding Interacting selectively with a transcription factor, any protein required to initiate or regulate transcription. MF
GO:0008135 translation factor activity, nucleic acid binding Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome. MF
GO:0008132 pancreatic elastase activity Catalysis of the hydrolysis of proteins, including elastin. MF
GO:0008133 collagenase activity NA MF
GO:0008130 neutrophil collagenase activity Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I. MF
GO:0008131 amine oxidase activity Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. MF
GO:0051480 cytosolic calcium ion homeostasis The regulation of the levels, transport, and metabolism of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. BP
GO:0008681 2-octaprenyl-6-methoxyphenol hydroxylase activity NA MF
GO:0008682 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone. MF
GO:0005802 Golgi trans face The concave side of the Golgi apparatus, from which secretory vesicles emerge. CC
GO:0008684 2-oxopent-4-enoate hydratase activity Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. MF
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity Catalysis of the reaction: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP. MF
GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate. MF
GO:0008687 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde. MF
GO:0008688 3-(3-hydroxy-phenyl)propionate hydroxylase activity NA MF
GO:0008689 3-demethylubiquinone-9 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9. MF
GO:0045206 MAPK phosphatase transporter activity Enables the directed movement of MAPK phosphatase into, out of, within or between cells. MF
GO:0045205 MAPK transporter activity Enables the directed movement of MAP kinase into, out of, within or between cells. MF
GO:0045204 MAPK export from nucleus The directed movement of a MAP kinase from the nucleus to the cytoplasm. BP
GO:0045203 integral to outer membrane (sensu ProteoBacteria) Penetrating at least one phospholipid bilayer of the external outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0045202 synapse The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. CC
GO:0045201 maintenance of neuroblast polarity The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. BP
GO:0045200 establishment of neuroblast polarity The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. BP
GO:0045209 MAPK phosphatase export from nucleus, leptomycin B sensitive Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm. BP
GO:0045208 MAPK phosphatase export from nucleus The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm. BP
GO:0022002 wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate The series of molecular signals that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell. BP
GO:0022003 fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate The series of molecular signals that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. BP
GO:0022000 forebrain induction by the anterior neural ridge The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate. BP
GO:0022001 negative regulation of anterior neural cell fate of the neural plate Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a cell from adopting an anterior neural cell fate. BP
GO:0022006 zona limitans intrathalamica formation The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon. BP
GO:0022007 convergent extension involved in neural plate elongation The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate. BP
GO:0022004 midbrain-hindbrain boundary maturation during brain development A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. BP
GO:0022005 midbrain-hindbrain boundary maturation during neural plate development A developmental process involved in neural plate development. This process is independent of morphogenetic (shape) change, and is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. BP
GO:0022008 neurogenesis Generation of cells within the nervous system. BP
GO:0022009 central nervous system vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. BP
GO:0007234 osmosensory signaling pathway via two-component system A series of molecular signals generated in response to osmotic change, as mediated through a two-component (phosphorelay) system. BP
GO:0015553 xanthosine transporter activity Enables the directed movement of xanthosine, xanthine riboside, into, out of, within or between cells. MF
GO:0015550 galacturonate transporter activity Enables the directed movement of galacturonate into, out of, within or between cells. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. MF
GO:0015129 lactate transporter activity Enables the directed movement of lactate into, out of, within or between cells. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. MF
GO:0015128 gluconate transporter activity Enables the directed movement of gluconate into, out of, within or between cells. Gluconate is the aldonic acid derived from glucose. MF
GO:0015127 bilirubin transporter activity Enables the directed movement of bilirubin into, out of, within or between cells. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile. MF
GO:0015126 canalicular bile acid transporter activity NA MF
GO:0015125 bile acid transporter activity Enables the directed movement of bile acid into, out of, within or between cells. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. MF
GO:0015124 allantoate transporter activity Enables the directed movement of allantoate into, out of, within or between cells. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen. MF
GO:0015123 acetate transporter activity Enables the directed movement of acetate into, out of, within or between cells. Acetate is the 2-carbon carboxylic acid ethanoic acid. MF
GO:0015121 phosphoenolpyruvate transporter activity Enables the directed movement of phosphoenolpyruvate into, out of, within or between cells. Phosphoenolpyruvate is the phosphate ester formed from the hydroxy group of the enol tautomer of pyruvate. It is a key intermediate in glycolysis and gluconeogenesis, and in the biosynthesis of aromatic amino acids. MF
GO:0015120 phosphoglycerate transporter activity Enables the directed movement of phosphoglycerates into, out of, within or between cells. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis. MF
GO:0016479 negative regulation of transcription from RNA polymerase I promoter Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter. BP
GO:0016474 sodium-translocating V-type ATPase complex NA CC
GO:0016475 detection of nuclear:cytoplasmic ratio The process by which the size of the nucleus with respect to its cytoplasm is sensed by a cell. BP
GO:0016476 shape changes of embryonic cells NA BP
GO:0016477 cell migration The orderly movement of cells from one site to another, often during the development of a multicellular organism. BP
GO:0016471 hydrogen-translocating V-type ATPase complex Complex composed of a V1 and a V0 domain to form an active V-type ATPase that functions as a proton pump. CC
GO:0016472 sodium-transporting two-sector ATPase complex A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. CC
GO:0016473 sodium-translocating F-type ATPase complex NA CC
GO:0043319 positive regulation of cytotoxic T cell degranulation Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation. BP
GO:0043318 negative regulation of cytotoxic T cell degranulation Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. BP
GO:0043317 regulation of cytotoxic T cell degranulation Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation. BP
GO:0043316 cytotoxic T cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. BP
GO:0043315 positive regulation of neutrophil degranulation Any process that activates or increases the frequency, rate or extent of neutrophil degranulation. BP
GO:0043314 negative regulation of neutrophil degranulation Any process that stops, prevents, or reduces the rate of neutrophil degranulation. BP
GO:0043313 regulation of neutrophil degranulation Any process that modulates the frequency, rate, or extent of neutrophil degranulation. BP
GO:0043312 neutrophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil. BP
GO:0043311 positive regulation of eosinophil degranulation Any process that activates or increases the frequency, rate or extent of eosinophil degranulation. BP
GO:0043310 negative regulation of eosinophil degranulation Any process that stops, prevents, or reduces the rate of eosinophil degranulation. BP
GO:0046790 virion binding Interacting selectively with a virion, either by binding to components of the capsid or the viral envelope. MF
GO:0046791 suppression by virus of host complement neutralization Viral processes that result in the inhibition of complement neutralization of the host cell. BP
GO:0046792 suppression by virus of host cell cycle arrest Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur. BP
GO:0046793 induction by virus of modification of host RNA polymerase II The viral induction of modification to the host RNA polymerase II. BP
GO:0046794 virion transport The directed movement of a virion into, out of, or within a host cell. BP
GO:0046795 intracellular virion transport The directed movement of a virion within a host cell from one location to another. BP
GO:0046796 viral genome transport in host cell The directed movement of the viral genome(s) within a host cell. BP
GO:0046797 viral procapsid maturation The period of virion development during which the capsid components form the immature capsid and encapsulate the viral genome; the capsid often undergoes a number of structural alterations during this period. BP
GO:0046798 viral portal complex A multimeric ring of proteins through which the DNA enters and exits the viral capsid. CC
GO:0046799 recruitment of helicase-primase complex to DNA lesions The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair. BP
GO:0031338 regulation of vesicle fusion Any process that modulates the frequency, rate or extent of vesicle fusion. BP
GO:0031339 negative regulation of vesicle fusion Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fusion. BP
GO:0031330 negative regulation of cellular catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. BP
GO:0031331 positive regulation of cellular catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. BP
GO:0031332 RNAi effector complex Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. CC
GO:0031333 negative regulation of protein complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of protein complex assembly. BP
GO:0031334 positive regulation of protein complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly. BP
GO:0031335 regulation of sulfur amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. BP
GO:0031336 negative regulation of sulfur amino acid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. BP
GO:0031337 positive regulation of sulfur amino acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. BP
GO:0050410 3-oxolaurate decarboxylase activity Catalysis of the reaction: 3-oxododecanoate = 2-undecanone + CO2. MF
GO:0050411 agaritine gamma-glutamyltransferase activity Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor. MF
GO:0050412 cinnamate beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + trans-cinnamate = UDP + trans-cinnamoyl beta-D-glucoside. MF
GO:0050413 D-alanine 2-hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = tetrahydrofolate + 2-methylserine. MF
GO:0050414 formimidoylaspartate deiminase activity Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3. MF
GO:0050415 formimidoylglutamase activity Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. MF
GO:0050416 formimidoylglutamate deiminase activity Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3. MF
GO:0050417 glutamin-(asparagin-)ase activity Catalysis of the reaction: H2O + L-glutamine (or L-asparagine) = NH3 + L-glutamate (or L-aspartate). MF
GO:0050418 hydroxylamine reductase activity Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor. MF
GO:0050419 hydroxymandelonitrile lyase activity Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate. MF
GO:0018861 4-chlorobenzoate-CoA ligase activity Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. Requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway. MF
GO:0018860 anthranilate--CoA ligase activity Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA. MF
GO:0018863 phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene. MF
GO:0018862 phenylphosphate carboxylase activity Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate. MF
GO:0018865 acrylonitrile metabolic process The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. BP
GO:0018864 acetylene metabolic process The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes. BP
GO:0018867 alpha-pinene metabolic process The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor. BP
GO:0018866 adamantanone metabolic process The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. BP
GO:0018869 2-aminobenzoate metabolic process The chemical reactions and pathways involving 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2. BP
GO:0018868 2-aminobenzenesulfonate metabolic process The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. BP
GO:0000910 cytokinesis The processes resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components. BP
GO:0000911 cytokinesis by cell plate formation The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. BP
GO:0000912 cytokinesis, formation of actomyosin apparatus The formation of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis. BP
GO:0000913 preprophase band formation The process of marking the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation. BP
GO:0000914 phragmoplast formation The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles). BP
GO:0000915 cytokinesis, contractile ring formation The process of formation of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis. BP
GO:0000916 cytokinesis, contractile ring contraction The process of an actomyosin ring, which functions in cytokinesis, getting smaller in diameter. BP
GO:0000917 barrier septum formation The process of making a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material. BP
GO:0000918 selection of site for barrier septum formation The process of marking the site where a barrier septum will form. BP
GO:0000919 cell plate formation The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast. BP
GO:0032018 2-methylbutanal reductase activity Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+. MF
GO:0032019 mitochondrial cloud A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material. CC
GO:0032010 phagolysosome A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. CC
GO:0032011 ARF protein signal transduction A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state. BP
GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. BP
GO:0032013 negative regulation of ARF protein signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of ARF protein signal transduction. BP
GO:0032014 positive regulation of ARF protein signal transduction Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction. BP
GO:0032015 regulation of Ran protein signal transduction Any process that modulates the frequency, rate or extent of Ran protein signal transduction. BP
GO:0032016 negative regulation of Ran protein signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of Ran protein signal transduction. BP
GO:0032017 positive regulation of Ran protein signal transduction Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction. BP
GO:0019808 polyamine binding Interacting selectively with polyamines, organic compounds containing two or more amino groups. MF
GO:0019809 spermidine binding Interacting selectively with spermidine, N-(3-aminopropyl)-1,4-diaminobutane. MF
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain. BP
GO:0019801 cyclization of asparagine, during protein splicing The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing. BP
GO:0019802 cyclization of glutamine, during protein splicing The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing. BP
GO:0019803 peptidyl-aspartic acid carboxylation The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid. BP
GO:0019804 quinolinate synthetase complex A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate. CC
GO:0019805 quinolinate biosynthetic process The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. BP
GO:0019806 bromide peroxidase activity Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide. MF
GO:0019807 aspartoacylase activity Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. MF
GO:0002408 myeloid dendritic cell chemotaxis The movement of a myeloid dendritic cell in response to an external stimulus. BP
GO:0002409 Langerhans cell chemotaxis The movement of a Langerhans cell in response to an external stimulus. BP
GO:0002404 antigen sampling in mucosal-associated lymphoid tissue The process initiating the mucosal immune response which entails the apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue. BP
GO:0002405 antigen sampling by dendritic cells in mucosal-associated lymphoid tissue The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue. BP
GO:0002406 antigen sampling by M cells in mucosal-associated lymphoid tissue The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue. BP
GO:0002407 dendritic cell chemotaxis The movement of a dendritic cell in response to an external stimulus. BP
GO:0002400 tolerance induction in nasopharyngeal-associated lymphoid tissue Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT). BP
GO:0002401 tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT). BP
GO:0002402 B cell tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells. BP
GO:0002403 T cell tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells. BP
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat3 protein. BP
GO:0042519 regulation of tyrosine phosphorylation of Stat4 protein Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat4 protein. BP
GO:0042512 negative regulation of tyrosine phosphorylation of Stat1 protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat1 protein. BP
GO:0042513 regulation of tyrosine phosphorylation of Stat2 protein Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat2 protein. BP
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat1 protein. BP
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat1 protein. BP
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat3 protein. BP
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat3 protein. BP
GO:0042514 negative regulation of tyrosine phosphorylation of Stat2 protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat2 protein. BP
GO:0042515 positive regulation of tyrosine phosphorylation of Stat2 protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat2 protein. BP
GO:0006408 snRNA export from nucleus The directed movement of snRNA from the nucleus to the cytoplasm. BP
GO:0006409 tRNA export from nucleus The directed movement of tRNA from the nucleus to the cytoplasm. BP
GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within tRNA, resulting in a change in the properties of the tRNA. BP
GO:0006401 RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. BP
GO:0006402 mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. BP
GO:0006403 RNA localization The processes by which RNA is transported to, or maintained in, a specific location. BP
GO:0006404 RNA import into nucleus The import of RNA from the cytoplasm to the nucleus. BP
GO:0006405 RNA export from nucleus The directed movement of RNA from the nucleus to the cytoplasm. BP
GO:0006406 mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm. BP
GO:0006407 rRNA export from nucleus The directed movement of rRNA from the nucleus to the cytoplasm. BP
GO:0005179 hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects. MF
GO:0005178 integrin binding Interacting selectively with an integrin. MF
GO:0005171 hepatocyte growth factor receptor binding Interacting selectively with the hepatocyte growth factor receptor. MF
GO:0005170 neurotrophin TRKC receptor binding Interacting selectively with the neurotrophin TRKC receptor. MF
GO:0005173 stem cell factor receptor binding Interacting selectively with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. MF
GO:0048742 regulation of skeletal muscle fiber development Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. BP
GO:0005175 CD27 receptor binding Interacting selectively with a CD27, a receptor found on the surface of T cells and some B cells and NK cells. MF
GO:0005174 CD40 receptor binding Interacting selectively with CD40, a receptor found on the surface of all B-lymphocytes. MF
GO:0048747 muscle fiber development The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. BP
GO:0005176 ErbB-2 class receptor binding Interacting selectively with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2. MF
GO:0004802 transketolase activity Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate. MF
GO:0004803 transposase activity Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms. MF
GO:0004800 thyroxine 5'-deiodinase activity Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. MF
GO:0004801 transaldolase activity Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. MF
GO:0004806 triacylglycerol lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. MF
GO:0004807 triose-phosphate isomerase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. MF
GO:0004804 P-element encoded transposase activity NA MF
GO:0004805 trehalose-phosphatase activity Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate. MF
GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. MF
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. MF
GO:0007443 Malpighian tubule morphogenesis The process by which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. Morphogenesis pertains to the creation of form. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. BP
GO:0007442 hindgut morphogenesis The process by which the anatomical structures of the hindgut are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0007441 anterior midgut (ectodermal) morphogenesis The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0007440 foregut morphogenesis The process by which the anatomical structures of the foregut are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0007447 imaginal disc pattern formation The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. BP
GO:0015328 cystine porter activity NA MF
GO:0007445 determination of imaginal disc primordium Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment. BP
GO:0007444 imaginal disc development The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.). BP
GO:0015325 acetyl-CoA:CoA antiporter activity Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out). MF
GO:0015324 peptide-acetyl-CoA transporter activity NA MF
GO:0015327 cystine:glutamate antiporter activity Catalysis of the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out). MF
GO:0015326 cationic amino acid transporter activity NA MF
GO:0015321 sodium-dependent phosphate transporter activity NA MF
GO:0015320 phosphate carrier activity Catalysis of the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion). MF
GO:0015323 type V protein secretor activity NA MF
GO:0015322 oligopeptide porter activity NA MF
GO:0018322 protein amino acid tyrosinylation The addition of a tyrosine molecule to a protein amino acid. BP
GO:0018323 enzyme active site formation via L-cysteine sulfinic acid The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid. BP
GO:0018320 enzyme active site formation via S-methyl-L-cysteine The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine. BP
GO:0018321 protein amino acid glucuronylation The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose. BP
GO:0018326 enzyme active site formation via S-acetyl-L-cysteine The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine. BP
GO:0018327 enzyme active site formation via 1'-phospho-L-histidine The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine). BP
GO:0018324 enzyme active site formation via L-cysteine sulfenic acid The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase. BP
GO:0018325 enzyme active site formation via S-phospho-L-cysteine The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine. BP
GO:0018328 enzyme active site formation via 3'-phospho-L-histidine The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). BP
GO:0018329 enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase. BP
GO:0019493 arginine catabolic process to proline The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline. BP
GO:0019492 proline salvage Any process which produces the amino acid proline from derivatives of it, without de novo synthesis. BP
GO:0019491 ectoine biosynthetic process The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria. BP
GO:0019490 2-aminobenzenesulfonate desulfonation The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. BP
GO:0019497 hexachlorocyclohexane metabolic process The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution. BP
GO:0019496 serine-isocitrate lyase pathway NA BP
GO:0019495 proline catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate. BP
GO:0019494 proline oxidation NA BP
GO:0019499 cyanide metabolic process The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain. BP
GO:0019498 n-octane oxidation NA BP
GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. BP
GO:0051581 negative regulation of neurotransmitter uptake Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. BP
GO:0051580 regulation of neurotransmitter uptake Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. BP
GO:0051583 dopamine uptake The directed movement of dopamine into a cell, typically presynaptic neurons or glial cells. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. BP
GO:0051582 positive regulation of neurotransmitter uptake Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. BP
GO:0051585 negative regulation of dopamine uptake Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of dopamine into a cell. BP
GO:0051584 regulation of dopamine uptake Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell. BP
GO:0051587 inhibition of dopamine uptake Any process that prevents the activation of the directed movement of dopamine into a cell. BP
GO:0051586 positive regulation of dopamine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell. BP
GO:0051589 negative regulation of neurotransmitter transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells. BP
GO:0051588 regulation of neurotransmitter transport Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells. BP
GO:0015497 cadaverine:lysine antiporter activity Catalysis of the reaction: cadaverine(out) + lysine(in) = cadaverine(in) + lysine(out). MF
GO:0015496 putrescine:ornithine antiporter activity Catalysis of the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out). MF
GO:0015495 gamma-aminobutyric acid:hydrogen symporter activity Catalysis of the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). MF
GO:0015494 aromatic amino acid:hydrogen symporter activity Catalysis of the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in). MF
GO:0015493 lysine:hydrogen symporter activity Catalysis of the reaction: lysine(out) + H+(out) = lysine(in) + H+(in). MF
GO:0015492 phenylalanine:hydrogen symporter activity Catalysis of the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in). MF
GO:0015491 cation:cation antiporter activity Catalysis of the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). MF
GO:0015490 cadaverine transporter activity Enables the directed movement of cadaverine, 1,5-pentanediamine, into, out of, within or between cells. MF
GO:0015499 formate transporter activity Enables the directed movement of formate into, out of, within or between cells. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. MF
GO:0015498 pantothenate:sodium symporter activity Catalysis of the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in). MF
GO:0019145 aminobutyraldehyde dehydrogenase activity Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. MF
GO:0019144 ADP-sugar diphosphatase activity Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. MF
GO:0019147 (R)-aminopropanol dehydrogenase activity Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH + H+. MF
GO:0019146 arabinose-5-phosphate isomerase activity Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate. MF
GO:0019141 2-dehydropantolactone reductase (B-specific) activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. MF
GO:0019140 inositol 3-kinase activity Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate. MF
GO:0019143 3-deoxy-manno-octulosonate-8-phosphatase activity Catalysis of the reaction: 3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate. MF
GO:0019142 2-hydroxyglutarate synthase activity Catalysis of the reaction: propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA. MF
GO:0019149 3-chloro-D-alanine dehydrochlorinase activity Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3. MF
GO:0019148 D-cysteine desulfhydrase activity Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate. MF
GO:0016672 oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound. MF
GO:0016673 oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. MF
GO:0016670 oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. MF
GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. MF
GO:0016676 oxidoreductase activity, acting on heme group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen. MF
GO:0016677 oxidoreductase activity, acting on heme group of donors, nitrogenous group as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group. MF
GO:0021948 inward migration of deep nuclear neurons The directed movement of deep nuclear neurons from the rostrodorsal region of the cerebellar plate to their final more ventral position. BP
GO:0016675 oxidoreductase activity, acting on heme group of donors Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0021946 deep nuclear neuron cell migration The directed movement of deep nuclear neurons from the ventricular zone to the deep hindbrain nuclei. BP
GO:0021947 outward migration of deep nuclear neurons The directed movement of deep nuclear neurons from their ventrolateral origin to a rostrodorsal region of the cerebellar plate. BP
GO:0021944 neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration The changes in adhesion between neuronal cells and glial cells as a component of the process of hindbrain glial-mediated radial cell migration. BP
GO:0021945 calcium-mediated positive regulation of granule cell migration The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration. BP
GO:0021942 radial glia guided migration of Purkinje cell The migration of postmitotic Purkinje cells along radial glial cells from the ventricular zone to the Purkinje cell layer. BP
GO:0021943 formation of radial glial scaffolds The formation of scaffolds from radial glial cells. The scaffolds are used as a substrate for the radial migration of cells. BP
GO:0021940 positive regulation of granule cell precursor proliferation The process that activates or increases the rate or extent of granule cell precursor proliferation. BP
GO:0021941 negative regulation of granule cell precursor proliferation The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation. BP
GO:0000922 spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. CC
GO:0052056 negative regulation by symbiont of host protein function Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052057 modification by symbiont of host morphology or physiology via protein secreted by type III secretion system The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052054 negative regulation by symbiont of host protease activity Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052055 modification by symbiont of host protein function The process by which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052052 modification by symbiont of host morphology or physiology via protein secreted by type II secretion system The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052053 negative regulation by symbiont of host enzyme activity Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052050 interaction with host via substance secreted by type IV secretion system An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052051 interaction with host via protein secreted by type II secretion system An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052058 modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052059 evasion or tolerance by symbiont of host-produced reactive oxygen species The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042737 drug catabolic process The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease. BP
GO:0015655 alanine:sodium symporter activity Catalysis of the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in). MF
GO:0042739 endogenous drug catabolic process The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism. BP
GO:0031138 negative regulation of conjugation with cellular fusion Any process that decreases the rate or frequency of conjugation with cellular fusion. BP
GO:0031139 positive regulation of conjugation with cellular fusion Any process that increases the rate or frequency of conjugation with cellular fusion. BP
GO:0031136 positive regulation of conjugation Any process that increases the rate or frequency of conjugation. BP
GO:0031137 regulation of conjugation with cellular fusion Any process that modulates the rate or frequency of conjugation with cellular fusion. BP
GO:0031134 sister chromatid biorientation The cell cycle process whereby sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. BP
GO:0031135 negative regulation of conjugation Any process that decreases the rate of conjugation. BP
GO:0031132 serine 3-dehydrogenase L-serine + NADP+ = 2-ammoniomalonate semialdehyde + NADPH + H+. MF
GO:0031133 regulation of axon diameter Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained. BP
GO:0031130 creation of an inductive signal The process by which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter. BP
GO:0031131 reception of an inductive signal The process by which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change. BP
GO:0015651 quaternary ammonium group transporter activity Enables the directed movement of quaternary ammonium groups into, out of, within or between cells. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. MF
GO:0015650 lactate:hydrogen symporter activity Catalysis of the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in). MF
GO:0015653 glycine betaine:hydrogen symporter activity Catalysis of the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in). MF
GO:0015652 quaternary ammonium group:hydrogen symporter activity Catalysis of the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in). MF
GO:0031680 G-protein beta/gamma-subunit complex The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange. CC
GO:0031681 G-protein beta-subunit binding Interacting selectively with a G-protein beta subunit. MF
GO:0031682 G-protein gamma-subunit binding Interacting selectively with a G-protein gamma subunit. MF
GO:0031683 G-protein beta/gamma-subunit binding Interacting selectively with a complex of G-protein beta/gamma subunits. MF
GO:0031684 heterotrimeric G-protein complex cycle The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits. BP
GO:0031685 adenosine receptor binding Interacting selectively with an adenosine receptor. MF
GO:0031686 A1 adenosine receptor binding Interacting selectively with an A1 adenosine receptor. MF
GO:0031687 A2A adenosine receptor binding Interacting selectively with an A2A adenosine receptor. MF
GO:0031688 A2B adenosine receptor binding Interacting selectively with an A2B adenosine receptor. MF
GO:0031689 A3 adenosine receptor binding Interacting selectively with an A3 adenosine receptor. MF
GO:0051808 translocation of peptides or proteins into other organism during symbiotic interaction The directed movement of peptides or proteins produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051809 passive evasion of immune response of other organism during symbiotic interaction Any process by which an organism avoids the immune response of a second organism without directly interfering with the second organism's immune system, where the two organisms are in a symbiotic interaction. BP
GO:0051804 positive regulation of cytolysis of cells in other organism during symbiotic interaction Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051805 evasion or tolerance of immune response of other organism during symbiotic interaction Any process by which an organism avoids the immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051806 entry into cell of other organism during symbiotic interaction The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051807 evasion or tolerance of defense response of other organism during symbiotic interaction Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense response; the defense response is mounted by the second organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction. BP
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidyl inositol-4-phosphate + phosphate. MF
GO:0051801 cytolysis of cells in other organism during symbiotic interaction The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction. BP
GO:0051802 regulation of cytolysis of cells in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051803 negative regulation of cytolysis of cells in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0009454 aerotaxis The directed movement of a motile cell or organism in response to environmental oxygen. BP
GO:0009455 redox taxis The directed movement of a motile cell or organism in response to redox potential. BP
GO:0009452 RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript. BP
GO:0009453 energy taxis The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. BP
GO:0009450 gamma-aminobutyric acid catabolic process The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. BP
GO:0009451 RNA modification The covalent alteration of one or more nucleotides within RNA, resulting in a change in the properties of the RNA. BP
GO:0046967 cytosol to ER transport The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell. BP
GO:0046966 thyroid hormone receptor binding Interacting selectively with a thyroid hormone receptor. MF
GO:0046965 retinoid X receptor binding Interacting selectively with a retinoid X receptor. MF
GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transporter activity Enables the directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of, within or between cells. MF
GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of, within or between cells. BP
GO:0046962 sodium-transporting ATPase activity, rotational mechanism Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out), by a rotational mechanism. MF
GO:0046961 hydrogen ion transporting ATPase activity, rotational mechanism Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. MF
GO:0046960 sensitization An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched. BP
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 9 of the histone H3 protein. MF
GO:0046968 peptide antigen transport The directed movement of a peptide antigen into, out of, within or between cells. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. BP
GO:0008490 arsenite porter activity Catalysis of the movement of arsenite by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. MF
GO:0008493 tetracycline transporter activity Enables the directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). MF
GO:0008495 protoheme IX farnesyltransferase activity NA MF
GO:0008494 translation activator activity Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. MF
GO:0008496 mannan endo-1,6-alpha-mannosidase activity Catalysis of the random hydrolysis of 1,6-alpha-D-mannosidic linkages in unbranched 1,6-mannans. MF
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. MF
GO:0045434 negative regulation of female receptivity, post-mating Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating. BP
GO:0045435 lycopene epsilon cyclase activity Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene). MF
GO:0045436 lycopene beta cyclase activity Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively. MF
GO:0045437 uridine nucleosidase activity Catalysis of the reaction: uridine + H2O = D-ribose + uracil. MF
GO:0045430 chalcone isomerase activity Catalysis of the reaction: a chalcone = a flavanone. MF
GO:0045431 flavonol synthase activity Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O. MF
GO:0045432 leucoanthocyanidin dioxygenase activity Catalysis of the alpha-ketoglutarate-dependent oxidation of leucoanthocyanidins into anthocyanidins. MF
GO:0045433 male courtship behavior (sensu Insecta), song production The process during wing vibration where the male produces a species-specific acoustic signal called a love song. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0045438 L-cysteinyl-D-valine synthetase activity Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol. MF
GO:0045439 isopenicillin-N epimerase activity Catalysis of the reaction: isopenicillin-N = penicillin-N. MF
GO:0047368 UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine 4-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = UDP-N-acetyl-D-galactosamine 4,6-bissulfate + adenosine 3',5'-bisphosphate. MF
GO:0047369 succinate-hydroxymethylglutarate CoA-transferase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate. MF
GO:0047366 quercetin-3-sulfate 4'-sulfotransferase activity Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,4'-bissulfate + adenosine 3',5'-bisphosphate. MF
GO:0047367 quercetin-3,3'-bissulfate 7-sulfotransferase activity Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate. MF
GO:0047364 desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: desulfoglucotropeolin + 3'-phosphoadenosine 5'-phosphosulfate = glucotropeolin + adenosine 3',5'-bisphosphate. MF
GO:0047365 quercetin-3-sulfate 3'-sulfotransferase activity Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3'-bissulfate + adenosine 3',5'-bisphosphate. MF
GO:0047362 thiosulfate-dithiol sulfurtransferase activity Catalysis of the reaction: dithioerythritol + S2O3(2-) (thiosulfate) = H2S + dithioerythritol disulfide + SO3(2-) (sulfite). MF
GO:0047363 triglucosylalkylacylglycerol sulfotransferase activity Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate. MF
GO:0047360 undecaprenyl-phosphate galactose phosphotransferase activity Catalysis of the reaction: undecaprenyl phosphate + UDP-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP. MF
GO:0047361 phosphomannan mannosephosphotransferase activity Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP. MF
GO:0002729 positive regulation of natural killer cell cytokine production Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production. BP
GO:0002728 negative regulation of natural killer cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production. BP
GO:0002725 negative regulation of T cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. BP
GO:0002724 regulation of T cell cytokine production Any process that modulates the frequency, rate, or extent of T cell cytokine production. BP
GO:0002727 regulation of natural killer cell cytokine production Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production. BP
GO:0002726 positive regulation of T cell cytokine production Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. BP
GO:0002721 regulation of B cell cytokine production Any process that modulates the frequency, rate, or extent of B cell cytokine production. BP
GO:0002720 positive regulation of cytokine production during immune response Any process that activates or increases the frequency, rate, or extent of cytokine production during immune response. BP
GO:0002723 positive regulation of B cell cytokine production Any process that activates or increases the frequency, rate, or extent of B cell cytokine production. BP
GO:0002722 negative regulation of B cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production. BP
GO:0046181 ketogluconate catabolic process The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. BP
GO:0046180 ketogluconate biosynthetic process The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group. BP
GO:0046183 L-idonate catabolic process The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. BP
GO:0046182 L-idonate biosynthetic process The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. BP
GO:0046185 aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. BP
GO:0046184 aldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O. BP
GO:0046187 acetaldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. BP
GO:0046186 acetaldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol. BP
GO:0046189 phenol biosynthetic process The chemical reactions and pathways resulting in the formation of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers. BP
GO:0046188 methane catabolic process The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. BP
GO:0035114 appendage morphogenesis (sensu Endopterygota) The process by which the anatomical structures of appendages are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0035115 embryonic forelimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. The forelimbs are the front limbs of an animal. BP
GO:0002095 caveolar macromolecular signaling complex A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3). CC
GO:0002094 polyprenyltransferase activity Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). MF
GO:0002093 auditory receptor cell morphogenesis Any process that alters the mass volume or shape of an auditory receptor cell. BP
GO:0002092 positive regulation of receptor internalization Any process that activates or increases the frequency, rate or extent of receptor internalization. BP
GO:0002091 negative regulation of receptor internalization Any process that stops, prevents or reduces the frequency, rate or extent of receptor internalization. BP
GO:0002090 regulation of receptor internalization Any process that modulates the frequency, rate or extent of receptor internalization. BP
GO:0035118 embryonic pectoral fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted lateraly and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. BP
GO:0035119 embryonic pelvic fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. BP
GO:0002099 tRNA wobble guanine modification The process whereby a guanine in t position 34 of a tRNA is post-transcriptionally modified. BP
GO:0002098 tRNA wobble uridine modification The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified. BP
GO:0047588 5-aminopentanamidase activity Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3. MF
GO:0047589 5-aminovalerate transaminase activity Catalysis of the reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate. MF
GO:0047582 4-methyleneglutaminase activity Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH3. MF
GO:0047583 4-methyloxaloacetate esterase activity Catalysis of the reaction: oxaloacetate 4-methyl ester + H2O = oxaloacetate + methanol. MF
GO:0047580 4-hydroxyproline epimerase activity Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline. MF
GO:0047581 4-methyleneglutamate-ammonia ligase activity Catalysis of the reaction: ATP + 4-methylene-L-glutamate + NH3 = AMP + diphosphate + 4-methylene-L-glutamine. MF
GO:0047586 5'-acylphosphoadenosine hydrolase activity Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate. MF
GO:0047587 5-alpha-hydroxysteroid dehydratase activity Catalysis of the reaction: 5-alpha-ergosta-7,22-diene-3-beta,5-diol = ergosterol + H2O. MF
GO:0047584 4-oxalmesaconate hydratase activity Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O. MF
GO:0047585 4-pyridoxolactonase activity Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate. MF
GO:0043299 leukocyte degranulation The regulated exocytosis of secretory granules by a leukocyte. BP
GO:0043292 contractile fiber Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. CC
GO:0043293 apoptosome A multisubunit protein complex involved in the activation of apoptosis. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms. CC
GO:0043290 apocarotenoid catabolic process The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid. BP
GO:0043291 RAVE complex A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme. CC
GO:0043296 apical junction complex A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. CC
GO:0043297 apical junction assembly The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation and bonding together of its constituents. BP
GO:0043294 mitochondrial glutamate synthase complex (NADH) A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. CC
GO:0043295 glutathione binding Interacting selectively with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine. MF
GO:0048589 developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. BP
GO:0048588 developmental cell growth The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. BP
GO:0048587 regulation of short-day photoperiodism, flowering Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. BP
GO:0048586 regulation of long-day photoperiodism, flowering Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. BP
GO:0048585 negative regulation of response to stimulus Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. BP
GO:0048584 positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. BP
GO:0048583 regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. BP
GO:0048582 positive regulation of post-embryonic development Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. BP
GO:0048581 negative regulation of post-embryonic development Any process that stops, prevents or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. BP
GO:0048580 regulation of post-embryonic development Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. BP
GO:0045988 negative regulation of striated muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle contraction. BP
GO:0045989 positive regulation of striated muscle contraction Any process that activates or increases the frequency, rate or extent of striated muscle contraction. BP
GO:0045984 negative regulation of pyrimidine base metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases. BP
GO:0045985 positive regulation of pyrimidine base metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases. BP
GO:0045986 negative regulation of smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction. BP
GO:0045987 positive regulation of smooth muscle contraction Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. BP
GO:0045980 negative regulation of nucleotide metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. BP
GO:0045981 positive regulation of nucleotide metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. BP
GO:0045982 negative regulation of purine base metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine bases. BP
GO:0045983 positive regulation of purine base metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases. BP
GO:0009841 mitochondrial endopeptidase Clp complex A Clp endopeptidase complex located in the mitochondrion. CC
GO:0009840 chloroplastic endopeptidase Clp complex A Clp endopeptidase complex located in the chloroplast. CC
GO:0009843 thylakoid (sensu Glaucocystophyceae) Photosynthetic membrane resembling that of cyanobacteria found in the cyanelles of certain algae. As in, but not restricted to, the glaucocystophytes (Glaucocystophyceae, ncbi_taxonomy_id:38254). CC
GO:0009842 cyanelle Plastid type found in Glaucophyta having unstacked thylakoid membranes bearing phycobilisomes; cyanelles are bound by a double membrane and a peptidoglycan layer. CC
GO:0009845 seed germination The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis. BP
GO:0043129 surfactant homeostasis Any of the processes involved in the maintenance of an equilibrium of the surface-active lipoprotein mixture which coats the alveoli. BP
GO:0009847 spore germination The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall). BP
GO:0009846 pollen germination The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture. BP
GO:0009849 tryptophan-independent indoleacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan. BP
GO:0009848 indoleacetic acid biosynthetic process via tryptophan The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan. BP
GO:0043126 regulation of 1-phosphatidylinositol 4-kinase activity Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase. BP
GO:0043127 negative regulation of 1-phosphatidylinositol 4-kinase activity Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase. BP
GO:0043120 tumor necrosis factor binding Interacting selectively with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. MF
GO:0043121 neurotrophin binding Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth. MF
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade. BP
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. BP
GO:0052091 modulation by symbiont of nutrient release from host Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042459 octopine catabolic process to proline The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline. BP
GO:0042458 nopaline catabolic process to proline The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline. BP
GO:0042453 deoxyguanosine metabolic process The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. BP
GO:0042452 deoxyguanosine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. BP
GO:0042451 purine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0042450 arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. BP
GO:0042457 ethylene catabolic process The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. BP
GO:0042455 ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0042454 ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0042989 sequestering of actin monomers The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers. BP
GO:0042988 X11-like protein binding Interacting selectively with X11-like protein, a neuron-specific adaptor protein. MF
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. BP
GO:0042984 regulation of amyloid precursor protein biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. BP
GO:0042987 amyloid precursor protein catabolic process The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. BP
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid. BP
GO:0042981 regulation of apoptosis Any process that modulates the occurrence or rate of cell death by apoptosis. BP
GO:0042980 cystic fibrosis transmembrane conductance regulator binding Interacting selectively with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein. MF
GO:0042983 amyloid precursor protein biosynthetic process The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. BP
GO:0042982 amyloid precursor protein metabolic process The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. BP
GO:0021914 negative regulation of smoothened signaling pathway in ventral spinal cord patterning Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord. BP
GO:0050201 fucokinase activity Catalysis of the reaction: ATP + 6-deoxy-L-galactose = ADP + 6-deoxy-L-galactose 1-phosphate. MF
GO:0050200 plasmalogen synthase activity Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine. MF
GO:0050203 oxalate-CoA ligase activity Catalysis of the reaction: ATP + oxalate + CoA = AMP + diphosphate + oxalyl-CoA. MF
GO:0050202 octopamine dehydratase activity Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3. MF
GO:0050205 oxamate carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + oxamate = phosphate + oxalureate. MF
GO:0050204 oxalomalate lyase activity Catalysis of the reaction: 3-oxalomalate = oxaloacetate + glyoxylate. MF
GO:0050207 plasmanylethanolamine desaturase activity Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O. MF
GO:0050206 oximinotransferase activity Catalysis of the reaction: pyruvate oxime + acetone = pyruvate + acetone oxime. MF
GO:0050209 polyvinyl-alcohol oxidase activity Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2. MF
GO:0050208 polysialic-acid O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9. MF
GO:0008828 dATP pyrophosphohydrolase activity Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate. MF
GO:0008829 dCTP deaminase activity Catalysis of the reaction: dCTP + H2O = dUTP + NH3. MF
GO:0008820 cobinamide phosphate guanylyltransferase activity Catalysis of the reaction: adenosylcobinamide-phosphate + GTP = adenosylcobinamide-GDP + diphosphate. MF
GO:0008821 crossover junction endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). MF
GO:0008823 cupric reductase activity NA MF
GO:0008824 cyanate hydratase activity Catalysis of the reaction: cyanate (NCO-) + H2O = carbamate (H2N-CO-O-). MF
GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. MF
GO:0008826 cysteine sulfinate desulfinase activity Catalysis of the reaction: 3-sulfinoalanine = L-alanine + SO3(2-). MF
GO:0008827 cytochrome o ubiquinol oxidase activity Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2R; cytochrome O is the electron acceptor. MF
GO:0019309 mannose catabolic process The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. BP
GO:0019308 dTDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate. BP
GO:0019303 D-ribose catabolic process The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose). BP
GO:0019302 D-ribose biosynthetic process The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose). BP
GO:0019301 rhamnose catabolic process The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. BP
GO:0019300 rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose. BP
GO:0019307 mannose biosynthetic process The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. BP
GO:0019306 GDP-D-rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate. BP
GO:0019305 dTDP-rhamnose biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. BP
GO:0019304 anaerobic rhamnose catabolic process The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen. BP
GO:0032609 interferon-gamma production The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032608 interferon-beta production The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032601 connective tissue growth factor production The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032603 fractalkine production The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032602 chemokine production The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032605 hepatocyte growth factor production The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032604 granulocyte macrophage colony-stimulating factor production The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032607 interferon-alpha production The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032606 interferon type I production The appearance of interferon type I due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0004222 metalloendopeptidase activity Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. MF
GO:0004221 ubiquitin thiolesterase activity Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. MF
GO:0042313 protein kinase C deactivation Any process resulting in the inhibition or termination of the activity of protein kinase C. BP
GO:0052117 aerotaxis in host environment The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052116 chemotaxis in host environment The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052115 energy taxis in host environment The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052114 adaptation to host pH environment The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052113 adaptation to host osmotic environment The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0004228 gelatinase A activity Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond. MF
GO:0052111 modification by symbiont of host structure The process by which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052110 occlusion by symbiont of host vascular system The process by which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0004229 gelatinase B activity Catalysis of the cleavage of gelatin types I and V and collagen types IV and V. MF
GO:0052119 negative energy taxis in host environment The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052118 positive energy taxis in host environment The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042317 penicillin catabolic process The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. BP
GO:0006618 SRP-dependent cotranslational protein targeting to membrane, signal sequence processing The removal of the signal peptide from a nascent protein during cotranslational membrane targeting. BP
GO:0006611 protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm. BP
GO:0006610 ribosomal protein import into nucleus The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0006613 cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner. BP
GO:0006612 protein targeting to membrane The process of directing proteins towards a membrane using signals contained within the protein. BP
GO:0006615 SRP-dependent cotranslational protein targeting to membrane, docking The process by which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting. BP
GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. BP
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition The process by which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. BP
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. BP
GO:0000723 telomere maintenance The maintenance of proper telomeric length and structure by processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences. BP
GO:0000722 telomere maintenance via recombination The maintenance of proper telomeric length by recombinational processes. BP
GO:0000721 (R,R)-butanediol dehydrogenase activity Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+. MF
GO:0000720 pyrimidine dimer repair via nucleotide-excision repair The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. BP
GO:0000727 double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. BP
GO:0000726 non-recombinational repair The repair of damaged DNA that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. BP
GO:0000725 recombinational repair The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. BP
GO:0000724 double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. BP
GO:0000729 DNA double-strand break processing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. BP
GO:0000728 gene conversion at mating-type locus, DNA double-strand break formation The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another. BP
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. MF
GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2. MF
GO:0004611 phosphoenolpyruvate carboxykinase activity Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2. MF
GO:0004610 phosphoacetylglucosamine mutase activity Catalysis of the reaction: N-acetyl-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. MF
GO:0004617 phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. MF
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. MF
GO:0004615 phosphomannomutase activity Catalysis of the reaction: D-mannose 1-phosphate = D-mannose 6-phosphate. MF
GO:0004614 phosphoglucomutase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. MF
GO:0004619 phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. MF
GO:0004618 phosphoglycerate kinase activity Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. MF
GO:0018173 peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine. BP
GO:0018172 peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine The, presumably, posttranslational modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine. BP
GO:0018171 peptidyl-cysteine oxidation The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid. BP
GO:0018170 C-terminal peptidyl-polyglutamic acid amidation The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus. BP
GO:0018177 protein amino acid uridylylation The addition of phospho-uridine to a protein amino acid. BP
GO:0018175 protein amino acid nucleotidylation The addition of a nucleotide to a protein amino acid. BP
GO:0018174 protein-heme P460 linkage The linkage of protein to heme P460. BP
GO:0018179 peptidyl-cysteine desulfurization The posttranslational desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate. BP
GO:0018178 peptidyl-threonine adenylylation The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine. BP
GO:0051268 alpha-keto amide reductase activity Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic. MF
GO:0051269 alpha-keto ester reductase activity Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic. MF
GO:0051264 mono-olein transacylation activity Catalysis of the reaction: mono-olein (mono-oleoylglycerol) + mono-olein = diolein (dioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid. MF
GO:0051265 diolein transacylation activity Catalysis of the reaction: diolein (dioleoylglycerol) + mono-olein (mono-oleoylglycerol) = triolein (trioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid; triolein or trioleoylglycerol is also known as olein. MF
GO:0051266 sirohydrochlorin ferrochelatase activity Catalysis of the reaction: sirohydrochlorin + Fe2+ = siroheme + 2 H+. MF
GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity Catalysis of the reaction: ethanolamine phosphate (EtN-P) + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. MF
GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. BP
GO:0051261 protein depolymerization The process by which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. BP
GO:0051262 protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. BP
GO:0051263 microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain. BP
GO:0015512 L-threonine permease activity NA MF
GO:0015513 nitrite uptake permease activity NA MF
GO:0015510 low-affinity tryptophan permease activity NA MF
GO:0015511 L-serine permease activity NA MF
GO:0015516 tartrate:succinate antiporter activity Catalysis of the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out). MF
GO:0015517 galactose:hydrogen symporter activity Catalysis of the reaction: galactose(out) + H+(out) = galactose(in) + H+(in). MF
GO:0015514 nitrite extrusion permease activity NA MF
GO:0015515 citrate:succinate antiporter activity Catalysis of the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out). MF
GO:0015518 arabinose:hydrogen symporter activity Catalysis of the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in). MF
GO:0015519 D-xylose:hydrogen symporter activity Catalysis of the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in). MF
GO:0021759 globus pallidus development The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain. BP
GO:0021758 putamen development The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain. BP
GO:0021757 caudate nucleus development The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain. BP
GO:0021756 striatum development The progression of the striatum over time from its initial formation until its mature state. The striatum is a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking. BP
GO:0021755 eurydendroid cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts. BP
GO:0021754 facial nucleus development The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure. BP
GO:0021753 superior salivary nucleus development The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. BP
GO:0021752 inferior salivary nucleus development The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure. BP
GO:0021751 salivary nucleus development The process whose specific outcome is the progression of the salivary nucleus over time, from its formation to the mature structure. BP
GO:0021750 vestibular nucleus development The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure. BP
GO:0001939 female pronucleus The pronucleus originating from the ovum that is being fertilized. CC
GO:0001938 positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation. BP
GO:0001931 uropod A rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated, found on the opposite side of the cell from the lamellipodium or immunological synapse, respectively. CC
GO:0001930 positive regulation of exocyst assembly Any process that increases the rate or extent of exocyst assembly. BP
GO:0001933 negative regulation of protein amino acid phosphorylation Any process that stops, prevents or decreases the rate of addition of phosphoric groups to amino acids within a protein. BP
GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphoric groups into an amino acid in a protein. BP
GO:0001935 endothelial cell proliferation The multiplication or reproduction of endothelial cells, resulting in the rapid expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. BP
GO:0001934 positive regulation of protein amino acid phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphoric groups to amino acids within a protein. BP
GO:0001937 negative regulation of endothelial cell proliferation Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. BP
GO:0001936 regulation of endothelial cell proliferation Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. BP
GO:0046347 mannosamine biosynthetic process The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. BP
GO:0046346 mannosamine catabolic process The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. BP
GO:0046345 abscisic acid catabolic process The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. BP
GO:0046344 ecdysteroid catabolic process The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. BP
GO:0046343 streptomycin metabolic process The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. BP
GO:0046342 CDP-diacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. BP
GO:0046341 CDP-diacylglycerol metabolic process The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. BP
GO:0046340 diacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. BP
GO:0016358 dendrite development The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. BP
GO:0046349 amino sugar biosynthetic process The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. BP
GO:0046348 amino sugar catabolic process The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. BP
GO:0008088 axon cargo transport The directed movement of organelles along microtubules in nerve cell axons. BP
GO:0016806 dipeptidyl-peptidase and tripeptidyl-peptidase activity Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain. MF
GO:0030452 group I intron catabolic process The chemical reactions and pathways resulting in the breakdown of an excised group I intron. BP
GO:0030450 regulation of complement activation, classical pathway Any process that modulates the frequency, rate or extent of the classical pathway of complement activation. BP
GO:0030451 regulation of complement activation, alternative pathway Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation. BP
GO:0043649 dicarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. BP
GO:0017008 protein-phycobiliviolin linkage The linkage of the chromophore phycobiliviolin to phycoerythrocyanin. BP
GO:0017009 protein-phycocyanobilin linkage The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin. BP
GO:0017002 activin receptor activity Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity. MF
GO:0017003 protein-heme linkage The covalent linkage of heme and a protein. BP
GO:0017000 antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. BP
GO:0017001 antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. BP
GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. BP
GO:0017007 protein-bilin linkage The covalent linkage of bilin and a protein. BP
GO:0017004 cytochrome complex assembly The aggregation and bonding together of a cytochrome. BP
GO:0017005 tyrosyl-DNA phosphodiesterase activity Catalysis of the hydrolysis of covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. MF
GO:0047919 GDP-mannose 6-dehydrogenase activity Catalysis of the reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH. MF
GO:0047918 GDP-mannose 3,5-epimerase activity Catalysis of the reaction: GDP-mannose = GDP-L-galactose. MF
GO:0047915 ganglioside galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine. MF
GO:0047914 gamma-glutamylhistamine synthase activity Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown. MF
GO:0047917 GDP-glucosidase activity Catalysis of the reaction: GDP-glucose + H2O = D-glucose + GDP. MF
GO:0047916 GDP-6-deoxy-D-talose 4-dehydrogenase activity Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+. MF
GO:0047911 galacturan 1,4-alpha-galacturonidase activity Catalysis of the reaction: 1,4-alpha-D-galacturonide(n) + H2O = 1,4-alpha-D-galacturonide(n-1) + D-galacturonate. MF
GO:0047910 galactose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH. MF
GO:0047913 gallate 1-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + gallate = UDP + 1-galloyl-beta-D-glucose. MF
GO:0047912 galacturonokinase activity Catalysis of the reaction: ATP + D-galacturonate = ADP + 1-phospho-alpha-D-galacturonate. MF
GO:0048758 companion cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member. BP
GO:0031491 nucleosome binding Interacting selectively with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. MF
GO:0031490 chromatin DNA binding Interacting selectively with DNA that is assembled into chromatin. MF
GO:0031493 nucleosomal histone binding Interacting selectively with a histone that is assembled into a nucleosome. MF
GO:0031492 nucleosomal DNA binding Interacting selectively with the DNA portion of a nucleosome. MF
GO:0031495 negative regulation of mating type switching Any process that stops, prevents or reduces the frequency, rate or extent of mating type switching. BP
GO:0031494 regulation of mating type switching Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. BP
GO:0031497 chromatin assembly The assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. BP
GO:0031496 positive regulation of mating type switching Any process that activates or increases the frequency, rate or extent of mating type switching. BP
GO:0031499 TRAMP complex A multiprotein complex, which in yeast consists of Trf4p, Air1p or Air2p and Mtr4p. This nuclear RNA surveillance and quality control complex is involved in the distributive polyadenylation of substrates that include: hypomodified and incorrectly folded tRNAs, snoRNA precursors and rRNA precursors. It is also required for the degradative activity of the nuclear exosome in vivo. CC
GO:0031498 chromatin disassembly The disassembly of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins. BP
GO:0009395 phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. BP
GO:0009394 2'-deoxyribonucleotide metabolic process The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009397 folic acid and derivative catabolic process The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives. BP
GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. BP
GO:0009391 ribonucleotide reductase activating enzyme activity NA MF
GO:0009390 dimethyl sulfoxide reductase complex An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide. CC
GO:0009392 N-acetyl-anhydromuramoyl-L-alanine amidase activity NA MF
GO:0009399 nitrogen fixation The process by which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide. BP
GO:0009398 FMN biosynthetic process The chemical reactions and pathways resulting in the formation of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. BP
GO:0052509 positive regulation by symbiont of host defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0005163 nerve growth factor receptor binding Interacting selectively with the nerve growth factor receptor. MF
GO:0016517 interleukin-12 receptor activity Combining with interleukin-12 to initiate a change in cell activity. MF
GO:0005160 transforming growth factor beta receptor binding Interacting selectively with the transforming growth factor beta receptor. MF
GO:0046508 hydrolase activity, acting on carbon-sulfur bonds Catalysis of the hydrolysis of any carbon-sulfur bond, C-S. MF
GO:0005166 neurotrophin p75 receptor binding Interacting selectively with the neurotrophin p75 receptor. MF
GO:0005167 neurotrophin TRK receptor binding Interacting selectively with a neurotrophin TRK receptor. MF
GO:0048754 branching morphogenesis of a tube The process by which the anatomical structures of branches in a tube are generated and organized. Morphogenesis pertains to the creation of form. A tube is a long hollow cylinder. BP
GO:0009649 entrainment of circadian clock The synchronization of a circadian rhythm to environmental time cues such as light. BP
GO:0009648 photoperiodism A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical daylength'. The critical daylength varies between species. BP
GO:0044257 cellular protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by individual cells. BP
GO:0044256 protein digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism. BP
GO:0044255 cellular lipid metabolic process The chemical reactions and pathways involving lipids, as carried out by individual cells. BP
GO:0009644 response to high light intensity A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. BP
GO:0044253 positive regulation of organismal metabolic process Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. BP
GO:0044252 negative regulation of organismal metabolic process Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. BP
GO:0009641 shade avoidance Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome. BP
GO:0044250 negative regulation of metabolic activity during hibernation The slowing of metabolic processes to very low levels in order to conserve energy during hibernation. BP
GO:0046506 sulfolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid. BP
GO:0008518 reduced folate carrier activity NA MF
GO:0008519 ammonium transporter activity Enables the directed movement of ammonium into, out of, within or between cells. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. MF
GO:0008514 organic anion transporter activity Enables the directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. MF
GO:0008515 sucrose transporter activity Enables the directed movement of sucrose into, out of, within or between cells. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. MF
GO:0008516 hexose uniporter activity Catalysis of the reaction: hexose(out) = hexose(in). MF
GO:0008517 folic acid transporter activity Enables the directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. MF
GO:0008510 sodium:bicarbonate symporter activity Catalysis of the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). MF
GO:0008511 sodium:potassium:chloride symporter activity Catalysis of the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in). MF
GO:0008512 sulfate:hydrogen symporter activity Catalysis of the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). MF
GO:0008513 organic cation porter activity NA MF
GO:0047285 flavonol-3-O-glycoside xylosyltransferase activity Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP. MF
GO:0047284 dolichyl-xylosyl-phosphate-protein xylosyltransferase activity Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein. MF
GO:0047287 lactosylceramide alpha-2,6-N-sialyltransferase activity Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP. MF
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide. MF
GO:0047281 dioxotetrahydropyrimidine phosphoribosyltransferase activity Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine. MF
GO:0047280 nicotinamide phosphoribosyltransferase activity Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide. MF
GO:0047283 dolichyl-phosphate D-xylosyltransferase activity Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP. MF
GO:0047282 dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity Catalysis of the reaction: streptidine 6-phosphate + dTDP-L-dihydrostreptose = O-1,4-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP. MF
GO:0047289 galactosyldiacylglycerol alpha-2,3-sialyltransferase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetylneuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP. MF
GO:0047288 monosialoganglioside sialyltransferase activity Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP. MF
GO:0045665 negative regulation of neuron differentiation Any process that stops, prevents or reduces the frequency, rate or extent of neuron differentiation. BP
GO:0045664 regulation of neuron differentiation Any process that modulates the frequency, rate or extent of neuron differentiation. BP
GO:0045667 regulation of osteoblast differentiation Any process that modulates the frequency, rate or extent of osteoblast differentiation. BP
GO:0045666 positive regulation of neuron differentiation Any process that activates or increases the frequency, rate or extent of neuron differentiation. BP
GO:0045661 regulation of myoblast differentiation Any process that modulates the frequency, rate or extent of myoblast differentiation. BP
GO:0045660 positive regulation of neutrophil differentiation Any process that activates or increases the frequency, rate or extent of neutrophil differentiation. BP
GO:0045663 positive regulation of myoblast differentiation Any process that activates or increases the frequency, rate or extent of myoblast differentiation. BP
GO:0045662 negative regulation of myoblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of myoblast differentiation. BP
GO:0045669 positive regulation of osteoblast differentiation Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. BP
GO:0045668 negative regulation of osteoblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of osteoblast differentiation. BP
GO:0047139 glutathione-homocystine transhydrogenase activity Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine. MF
GO:0047138 aquacobalamin reductase activity Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+. MF
GO:0047137 N-hydroxy-2-acetamidofluorene reductase activity Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+. MF
GO:0047136 4-(dimethylamino)phenylazoxybenzene reductase activity Catalysis of the reaction: 4-dimethylaminophenylazobenzene + NADP+ = 4-(dimethylamino)phenylazoxybenzene + NADPH + H+. MF
GO:0047135 bis-gamma-glutamylcystine reductase activity Catalysis of the reaction: 2 gamma-glutamylcysteine + NADP+ = bis-gamma-glutamylcystine + NADPH + H+. MF
GO:0047134 protein-disulfide reductase activity Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. MF
GO:0047133 dimethylamine dehydrogenase activity Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine. MF
GO:0047132 dihydrobenzophenanthridine oxidase activity Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine. MF
GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Catalysis of the reaction: H2O + NAD+ + saccharopine = NADH + allysine + L-glutamate. MF
GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity Catalysis of the reaction: H2O + NADP+ + saccharopine = NADPH + 2-oxoglutarate + L-lysine. MF
GO:0030841 positive regulation of intermediate filament polymerization Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization. BP
GO:0030840 negative regulation of intermediate filament polymerization Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament polymerization. BP
GO:0030843 negative regulation of intermediate filament depolymerization Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament depolymerization. BP
GO:0030842 regulation of intermediate filament depolymerization Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament. BP
GO:0030845 phospholipase C inhibition A signaling pathway that results in preventing the activation of phospholipase C in response to the signal. BP
GO:0030844 positive regulation of intermediate filament depolymerization Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization. BP
GO:0030847 transcription termination from Pol II promoter, RNA polymerase(A)-independent The process by which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end. BP
GO:0030846 transcription termination from Pol II promoter, RNA polymerase(A) coupled The process by which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination. BP
GO:0030849 autosome Any chromosome other than a sex chromosome. CC
GO:0030848 threo-3-hydroxyaspartate ammonia-lyase activity Catalysis of the reaction: threo-3-hydroxy-L-aspartate = oxaloacetate + NH3. MF
GO:0050821 protein stabilization The processes involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. BP
GO:0050820 positive regulation of coagulation Any process that activates or increases the frequency, rate or extent of coagulation. BP
GO:0050823 peptide antigen stabilization The processes involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded. BP
GO:0050822 peptide stabilization The processes involved in maintaining the structure and integrity of a peptide and preventing it from being degraded. BP
GO:0050825 ice binding Interacting selectively with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. MF
GO:0050824 water binding Interacting selectively with water (H2O). MF
GO:0050827 toxin receptor binding Interacting selectively with a toxin receptor, a receptor for substances that cause injury to living organisms. MF
GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. BP
GO:0050829 defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. BP
GO:0050828 regulation of liquid surface tension Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid. BP
GO:0050799 cocaine biosynthetic process The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. BP
GO:0050798 activated T cell proliferation The rapid expansion of a T cell population following activation by an antigenic stimulus. BP
GO:0050793 regulation of developmental process Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). BP
GO:0050792 regulation of viral life cycle Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. BP
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme. BP
GO:0050797 thymidylate synthase (FAD) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + FADH2 = dTMP + tetrahydrofolate + FAD. MF
GO:0050796 regulation of insulin secretion Any process that modulates the frequency, rate or extent of the regulated release of insulin. BP
GO:0050795 regulation of behavior Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli. BP
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. BP
GO:0046668 regulation of retinal programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. BP
GO:0046669 regulation of retinal cell programmed cell death (sensu Endopterygota) Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0046664 dorsal closure, amnioserosa morphology change The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo. BP
GO:0046665 amnioserosa maintenance Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. BP
GO:0046666 retinal cell programmed cell death Programmed cell death that occurs in the developing retina. BP
GO:0046667 retinal cell programmed cell death (sensu Endopterygota) Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidia. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0046660 female sex differentiation The establishment of the sex of a female organism by physical differentiation. BP
GO:0046661 male sex differentiation The establishment of the sex of a male organism by physical differentiation. BP
GO:0046662 regulation of oviposition Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium. BP
GO:0046663 dorsal closure, leading edge cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure. BP
GO:0005720 nuclear heterochromatin A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. CC
GO:0005721 centric heterochromatin Chromatin located near the centromere of a chromosome. CC
GO:0005722 beta-heterochromatin A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization. CC
GO:0005723 alpha-heterochromatin A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization. CC
GO:0005724 nuclear telomeric heterochromatin Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus. CC
GO:0002117 larval development (sensu Amphibia) The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. As in, but not restricted to, the amphibia (Amphibia, ncbi_taxonomy_id:8292). BP
GO:0005726 perichromatin fibrils Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts. CC
GO:0005727 extrachromosomal circular DNA Circular DNA structures that are not part of a chromosome. CC
GO:0005728 extrachromosomal rDNA circle Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats. CC
GO:0005729 2-micrometer circle DNA A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies. CC
GO:0002119 larval development (sensu Nematoda) The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-stage larva and ends with the end of the last larval stage (e.g. fourth-stage in C. elegans) before molting to adulthood. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0031828 type 2C serotonin receptor binding Interacting selectively with a type 2C serotonin receptor. MF
GO:0031829 type 4 serotonin receptor binding Interacting selectively with a type 4 serotonin receptor. MF
GO:0031820 P2Y11 nucleotide receptor binding Interacting selectively with a P2Y11 nucleotide receptor. MF
GO:0031821 metabotropic serotonin receptor binding Interacting selectively with a metabotropic serotonin receptor. MF
GO:0031822 type 1B serotonin receptor binding Interacting selectively with a type 1B serotonin receptor. MF
GO:0031823 type 1D serotonin receptor binding Interacting selectively with a type 1D serotonin receptor. MF
GO:0031824 type 1E serotonin receptor binding Interacting selectively with a type 1E serotonin receptor. MF
GO:0031825 type 1F serotonin receptor binding Interacting selectively with a type 1F serotonin receptor. MF
GO:0031826 type 2A serotonin receptor binding Interacting selectively with a type 2A serotonin receptor. MF
GO:0031827 type 2B serotonin receptor binding Interacting selectively with a type 2B serotonin receptor. MF
GO:0004451 isocitrate lyase activity Catalysis of the reaction: isocitrate = succinate + glyoxylate. MF
GO:0004450 isocitrate dehydrogenase (NADP+) activity Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. MF
GO:0004453 juvenile-hormone esterase activity Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone. MF
GO:0004452 isopentenyl-diphosphate delta-isomerase activity Catalysis of the isomerization of isopentenyl diphosphate into dimethylallyl diphosphate. MF
GO:0004455 ketol-acid reductoisomerase activity Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. MF
GO:0004454 ketohexokinase activity Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. MF
GO:0004457 lactate dehydrogenase activity Catalysis of the oxidation of lactate to produce pyruvate. MF
GO:0004456 phosphogluconate dehydratase activity Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O. MF
GO:0004459 L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. MF
GO:0004458 D-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c. MF
GO:0018771 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity Catalysis of the reaction: 2-hydroxy-6-keto-nona-2,4-dienedioate + OH- = cis-2-hydroxypenta-2,4-dienoate + succinate. MF
GO:0018770 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate + H2O = 2-(4-chlorophenyl)-3,3-dichloropropenoate. MF
GO:0018773 acetylpyruvate hydrolase activity Catalysis of the reaction: acetylpyruvate + H2O = acetate + pyruvate. MF
GO:0006968 cellular defense response A defense response that is mediated by cells. BP
GO:0018775 2-hydroxymuconate-semialdehyde hydrolase activity Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate. MF
GO:0018774 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate. MF
GO:0018777 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol). MF
GO:0018776 trans-chloroacrylic acid dehalogenase activity Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde. MF
GO:0018779 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity NA MF
GO:0006962 male-specific antibacterial humoral response An immune response against bacteria, specific to males and mediated through a body fluid. BP
GO:0006961 antibacterial humoral response (sensu Protostomia) An immune response against bacteria mediated through a body fluid. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0006960 antimicrobial humoral response (sensu Protostomia) An immune response against microbes mediated through a body fluid. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0006967 positive regulation of antifungal peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis. BP
GO:0006966 antifungal humoral response (sensu Protostomia) An immune response against a fungus mediated through a body fluid. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against anti-Gram-positive bacteria Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-positive bacteria. BP
GO:0006964 positive regulation of biosynthetic process of antibacterial peptides active against anti-Gram-negative bacteria Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against anti-Gram-negative bacteria. BP
GO:0048046 apoplast The protoplasts of cells in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. CC
GO:0048047 mating behavior, sex discrimination The actions or reactions of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner. BP
GO:0048045 trans-pentaprenyltranstransferase activity Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-hexaprenyl diphosphate. MF
GO:0048042 regulation of oviposition, post-mating Any process that modulates the frequency, rate or extent of egg-laying, following mating. BP
GO:0048040 UDP-glucuronate decarboxylase activity Catalysis of the reaction: UDP-D-glucuronic acid = UDP-D-xylose + CO2. MF
GO:0048041 focal adhesion formation Establishment and maturation of focal adhesions, complexes of intracellular signaling and structural proteins which provide a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. BP
GO:0048048 embryonic eye morphogenesis The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048049 embryonic eye morphogenesis (sensu Endopterygota) The process occurring in the embryo by which the anatomical structures of the larval eye are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0004189 tubulinyl-Tyr carboxypeptidase activity Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr. MF
GO:0004188 serine-type Pro-X carboxypeptidase activity Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid. MF
GO:0004183 carboxypeptidase E activity Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents. MF
GO:0004182 carboxypeptidase A activity Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. MF
GO:0004181 metallocarboxypeptidase activity Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism. MF
GO:0004180 carboxypeptidase activity Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. MF
GO:0004187 carboxypeptidase D activity Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents. MF
GO:0004186 carboxypeptidase C activity Catalysis of the release of a C-terminal amino acid with a broad specificity. MF
GO:0004185 serine carboxypeptidase activity Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a serine residue is at the active center. MF
GO:0004184 lysine carboxypeptidase activity Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma. MF
GO:0021519 spinal cord association neuron specification The process whereby a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway. BP
GO:0021518 spinal cord commissural neuron specification The process whereby a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway. BP
GO:0021515 cell differentiation in spinal cord The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021514 ventral spinal cord interneuron differentiation The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021517 ventral spinal cord development The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. BP
GO:0021516 dorsal spinal cord development The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. BP
GO:0021511 spinal cord patterning The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. BP
GO:0021510 spinal cord development The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. BP
GO:0021513 spinal cord dorsal-ventral patterning The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. BP
GO:0021512 spinal cord anterior-posterior patterning The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord. BP
GO:0050076 maleate isomerase activity Catalysis of the reaction: maleate = fumarate. MF
GO:0050077 maleylpyruvate isomerase activity Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate. MF
GO:0050074 malate-CoA ligase activity Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA. MF
GO:0050075 maleate hydratase activity Catalysis of the reaction: (R)-malate = maleate + H2O. MF
GO:0050072 m7G(5')pppN diphosphatase activity Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. MF
GO:0050073 macrolide 2'-kinase activity Catalysis of the reaction: ATP + oleandomycin = ADP + oleandomycin 2'-O-phosphate. MF
GO:0050070 lysolecithin acylmutase activity Catalysis of the reaction: 2-lysolecithin = 3-lysolecithin. MF
GO:0050071 lysyltransferase activity Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol. MF
GO:0050078 malonate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA. MF
GO:0050079 acetylenecarboxylate hydratase activity, producing 3-oxopropanoate Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O. MF
GO:0007371 ventral midline determination The rgionalization process by which the area where the ventral furrow will begin invagination is specified. BP
GO:0007370 ventral furrow formation Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation. BP
GO:0007373 determination of posterior border of ventral midline NA BP
GO:0007372 determination of anterior border of ventral midline NA BP
GO:0007375 anterior midgut invagination Internalization of the anterior midgut into the interior of the embryo. BP
GO:0007374 posterior midgut invagination Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior. BP
GO:0007377 germ-band extension Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further. BP
GO:0007376 cephalic furrow formation Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome. BP
GO:0007379 segment specification The process during which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. BP
GO:0007378 amnioserosa formation Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift. BP
GO:0009103 lipopolysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. BP
GO:0051677 pullulan biosynthetic process The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. BP
GO:0051676 pullulan metabolic process The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. BP
GO:0051675 isopullulanase activity Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose). MF
GO:0051674 localization of cell The processes by which a cell is transported to, and/or maintained in, a specific location. BP
GO:0051673 membrane disruption in another organism The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism. BP
GO:0051672 cell wall peptidoglycan catabolic process in another organism The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism. BP
GO:0051671 induction of autolysin activity in another organism Any process by which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism. BP
GO:0051670 inulinase activity Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin. MF
GO:0051679 6-alpha-maltosylglucose metabolic process The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose. BP
GO:0051678 pullulan catabolic process The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. BP
GO:0032239 regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells. BP
GO:0007456 eye development (sensu Endopterygota) The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007451 dorsal/ventral lineage restriction, imaginal disc Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment. BP
GO:0006138 NADH-O2 electron transport NA BP
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. BP
GO:0052320 positive regulation of phytoalexin metabolism Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins. BP
GO:0052321 negative regulation of phytoalexin metabolism Any process that stops, prevents or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins. BP
GO:0052322 positive regulation of phytoalexin biosynthesis Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. BP
GO:0052323 negative regulation of phytoalexin biosynthesis Any process that stops, prevents or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. BP
GO:0006133 5,10-methylenetetrahydrofolate oxidation NA BP
GO:0052329 positive regulation by organism of phytoalexin production in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0006136 succinate-O2 electron transport NA BP
GO:0006137 ubiquinone-8-O2 electron transport NA BP
GO:0009005 signal peptidase II activity Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group. MF
GO:0016960 class II ribonucleotide reductase activity NA MF
GO:0016961 class III ribonucleotide reductase activity NA MF
GO:0016966 nitric oxide reductase activity Catalysis of the reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor. MF
GO:0016964 alpha-2 macroglobulin receptor activity Combining with an alpha-2 macroglobulin to initiate a change in cell activity. MF
GO:0009004 signal peptidase I activity Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor. MF
GO:0050535 beta-primeverosidase activity Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol. MF
GO:0050533 5-phytase activity Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate. MF
GO:0009000 selenocysteine lyase activity Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor. MF
GO:0015703 chromate transport The directed movement of chromate into, out of, within or between cells. BP
GO:0015702 chlorate transport The directed movement of chlorate into, out of, within or between cells. BP
GO:0015701 bicarbonate transport The directed movement of bicarbonate into, out of, within or between cells. BP
GO:0015700 arsenite transport The directed movement of arsenite into, out of, within or between cells. BP
GO:0047739 cephalosporin-C deacetylase activity Catalysis of the reaction: cephalosporin C + H2O = deacetylcephalosporin C + acetate. MF
GO:0047738 cellobiose phosphorylase activity Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose. MF
GO:0015705 iodide transport The directed movement of iodide into, out of, within or between cells. BP
GO:0015704 cyanate transport The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of, within or between cells. BP
GO:0047735 cellobiose dehydrogenase (acceptor) activity Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor. MF
GO:0047734 CDP-glycerol diphosphatase activity Catalysis of the reaction: CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate. MF
GO:0015709 thiosulfate transport The directed movement of thiosulfate into, out of, within or between cells. BP
GO:0015708 silicate transport The directed movement of silicates into, out of, within or between cells. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. BP
GO:0047731 catechol oxidase (dimerizing) activity Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O. MF
GO:0047730 carnosine synthase activity Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. MF
GO:0047733 CDP-glucose 4,6-dehydratase activity Catalysis of the reaction: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O. MF
GO:0047732 CDP-abequose epimerase activity Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose. MF
GO:0043429 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. MF
GO:0043428 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. MF
GO:0043425 bHLH transcription factor binding Interacting selectively with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transciptional networks of many developmental pathways. MF
GO:0043424 protein histidine kinase binding Interacting selectively with protein histidine kinase. MF
GO:0043427 carbon fixation by 3-hydroxypropionate cycle An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product. BP
GO:0043426 MRF binding Interacting selectively with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of trascription factors. MF
GO:0043421 anthranilate catabolic process The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate). BP
GO:0043420 anthranilate metabolic process The chemical reactions and pathways involving anthranilate (2-aminobenzoate). BP
GO:0043423 3-phosphoinositide-dependent protein kinase binding Interacting selectively with a 3-phosphoinositide-dependent protein kinase. MF
GO:0043422 protein kinase B binding Interacting selectively with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. MF
GO:0043397 regulation of corticotropin-releasing hormone secretion Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion. BP
GO:0043396 corticotropin-releasing hormone secretion The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce adrenocorticotrophic hormone (ACTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle. BP
GO:0043395 heparan sulfate proteoglycan binding Interacting selectively with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. MF
GO:0043394 proteoglycan binding Interacting selectively with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. MF
GO:0043393 regulation of protein binding Any process that modulates the frequency, rate or extent of protein binding. BP
GO:0043392 negative regulation of DNA binding Any process that stops, prevents or reduces the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid. BP
GO:0043391 aflatoxin B2 metabolic process The chemical reactions and pathways involving aflatoxin B2, a mycotoxin produced by the fungal species Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius. BP
GO:0043390 aflatoxin B1 metabolic process The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi. BP
GO:0021652 rhombomere 1 formation The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021653 rhombomere 1 structural organization The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021650 vestibulocochlear nerve formation The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. BP
GO:0021651 rhombomere 1 morphogenesis The process by which the anatomical structure of rhombomere 1 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021656 rhombomere 2 structural organization The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021657 rhombomere 2 formation The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0043399 tRNA A64-2'-O-ribosylphosphate transferase activity Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA. MF
GO:0043398 HLH domain binding Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. MF
GO:0046062 dCDP metabolic process The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate. BP
GO:0046063 dCMP metabolic process The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate. BP
GO:0046060 dATP metabolic process The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). BP
GO:0046061 dATP catabolic process The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). BP
GO:0046066 dGDP metabolic process The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). BP
GO:0046067 dGDP catabolic process The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). BP
GO:0046064 dCMP biosynthetic process The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate. BP
GO:0046065 dCTP metabolic process The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate. BP
GO:0046068 cGMP metabolic process The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. BP
GO:0046069 cGMP catabolic process The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate. BP
GO:0030395 lactose binding Interacting selectively with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. MF
GO:0030394 fructoseglycine metabolic process The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine moiety in place of a hydroxyl group. BP
GO:0030397 membrane disassembly The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. BP
GO:0030391 fructosamine biosynthetic process The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. BP
GO:0030393 fructoselysine metabolic process The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine moiety in place of a hydroxyl group. BP
GO:0030392 fructosamine catabolic process The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. BP
GO:0030399 autophagic membrane disassembly The controlled breakdown of the membranes of autophagic vacuoles. BP
GO:0030398 peroxisomal membrane disassembly The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation. BP
GO:0030649 aminoglycoside antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. BP
GO:0030648 aminoglycoside antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. BP
GO:0030647 aminoglycoside antibiotic metabolic process The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. BP
GO:0030645 glucose catabolic process to butyrate The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum. BP
GO:0030644 chloride ion homeostasis The regulation of the levels, transport, and metabolism of chloride ions within a cell or between a cell and its external environment. BP
GO:0030643 phosphate ion homeostasis The regulation of the levels, transport, and metabolism of phosphate ions within a cell or between a cell and its external environment. BP
GO:0030642 sulfate ion homeostasis The regulation of the levels, transport, and metabolism of sulfate ions within a cell or between a cell and its external environment. BP
GO:0030641 hydrogen ion homeostasis The regulation of the levels, transport, and metabolism of hydrogen ions (protons) within a cell or between a cell and its external environment. BP
GO:0030640 polyketide catabolic process The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps. BP
GO:0032491 detection of molecule of fungal origin The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal. BP
GO:0020018 flagellar pocket membrane That part of the plasma membrane found in the flagellar pocket. CC
GO:0020013 rosetting The binding of parasite infected erythrocytes to uninfected erythrocytes. BP
GO:0020012 evasion or tolerance of host immune response Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0020011 apicoplast The plastid organelle found in apicomplexans. CC
GO:0020010 conoid Coiled microtubules within both the polar and basal rings of the apical complex of an apicomplexan parasite. CC
GO:0020017 flagellar membrane The lipid bilayer surrounding the flagellum; continuous with the plasma membrane. CC
GO:0020016 flagellar pocket Invagination of the plasma membrane from which a flagellum protrudes. CC
GO:0020015 glycosome Membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis. CC
GO:0020014 schizogony Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously. BP
GO:0045005 maintenance of fidelity during DNA-dependent DNA replication The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair. BP
GO:0045004 DNA replication proofreading Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity. BP
GO:0045007 depurination The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar. BP
GO:0045006 DNA deamination The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil. BP
GO:0045003 double-strand break repair via synthesis-dependent strand annealing SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. BP
GO:0045002 double-strand break repair via single-strand annealing Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. BP
GO:0047890 flavanone 4-reductase activity Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH. MF
GO:0047891 flavone 7-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone. MF
GO:0047892 flavone apiosyltransferase activity Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone. MF
GO:0047893 flavonol 3-O-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside. MF
GO:0045009 chitosome An intracellular membrane-bound particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum. CC
GO:0045008 depyrimidination The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar. BP
GO:0047896 formaldehyde transketolase activity Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone. MF
GO:0047897 formate-dihydrofolate ligase activity Catalysis of the reaction: ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate. MF
GO:0031518 CBF3 complex A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p. CC
GO:0031519 PcG protein complex A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. CC
GO:0031514 motile secondary cilium A cilium that consists of a 9 + 2 arrangement of microtubules, radial spokes, and a dynein apparatus. Motile cilia, found on cells that line the lumenal ducts of various tissues, beat with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. CC
GO:0031515 tRNA (m1A) methyltransferase complex A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. CC
GO:0031516 far-red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation. MF
GO:0031517 red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation. MF
GO:0031510 SUMO activating enzyme complex A conserved heterodimeric complex with SUMO activating enzyme activity. CC
GO:0031511 Mis6-Sim4 complex A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. CC
GO:0031512 motile primary cilium A specialized primary cilium that contains a 9 + 0 arrangement of microtubules, radial spokes, and a dynein apparatus, but no inner doublet microtubules. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface. CC
GO:0031513 nonmotile primary cilium An immotile primary cilium that may be missing the central pair of microtubules, or the central pair of microtubules and outer dynein arms. Some primary cilia also have altered arrangements of outer microtubules (fewer than nine and/or not always present as doublets). Nonmotile primary cilia typically function as sensory organelles that concentrate and organize sensory signaling molecules. CC
GO:0021938 smoothened signaling pathway in regulation of granule cell precursor cell proliferation The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in granule cells that contributes to the regulation of proliferation of the cells. BP
GO:0009568 amyloplast starch grain Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. CC
GO:0009569 chloroplast starch grain Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. CC
GO:0009562 megagametophyte nuclear migration The directed movement of a megagametophyte nucleus. BP
GO:0009563 synergid differentiation The process whereby a relatively unspecialized cell acquires specialized features of a synergid cell. BP
GO:0009560 female gametophyte egg cell differentiation Differentiation of the haploid egg cell within the plant gametophyte. BP
GO:0009561 megagametophyte nuclear division The partitioning of a megagametophyte nucleus and its genetic information. BP
GO:0009566 fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). BP
GO:0009567 double fertilization (sensu Magnoliophyta) Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0006935 chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). BP
GO:0021936 regulation of granule cell precursor proliferation The process that modulates the frequency, rate or extent of granule cell precursor proliferation. BP
GO:0000924 gamma-tubulin ring complex, centrosomal A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring. CC
GO:0016680 oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP. MF
GO:0032090 Pyrin domain binding Interacting selectively with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain. MF
GO:0032091 negative regulation of protein binding Any process that stops, prevents or reduces the frequency, rate or extent of protein binding. BP
GO:0032092 positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding. BP
GO:0032093 SAM domain binding Interacting selectively with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. MF
GO:0032094 response to food A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. BP
GO:0032095 regulation of response to food Any process that modulates the frequency, rate or extent of a response to a food stimulus. BP
GO:0032096 negative regulation of response to food Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. BP
GO:0032097 positive regulation of response to food Any process that activates, maintains, or increases the rate of a response to a food stimulus. BP
GO:0032098 regulation of appetite Any process which modulates appetite, the desire or physical craving for food. BP
GO:0032099 negative regulation of appetite Any process that reduces appetite. BP
GO:0046853 inositol and derivative phosphorylation The process of introducing a phosphoric group into inositol or an inositol derivative. Inositol is the cyclic alcohol 1,2,3,5/4,6-cyclohexanehexol which is widely distributed in nature and acts as a growth factor in animals and microorganisms. BP
GO:0046852 positive regulation of bone remodeling Any process that activates or increases the frequency, rate or extent of bone remodeling. BP
GO:0046851 negative regulation of bone remodeling Any process that stops, prevents or reduces the frequency, rate or extent of bone remodeling. BP
GO:0046850 regulation of bone remodeling Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. BP
GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. MF
GO:0046856 phosphoinositide dephosphorylation The process of removing one or more phosphoric groups from a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. BP
GO:0046855 inositol phosphate dephosphorylation The process of removing a phosphoric group from any mono- or polyphosphorylated inositol. BP
GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphoric groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. BP
GO:0046859 hydrogenosomal membrane The lipid bilayer surrounding a hydrogenosome. CC
GO:0046858 chlorosome A small compartment found in photosynthetic Chlorobiaceae bacteria. It contains bacteriochlorophyll c and is attached to the cytoplasmic membrane. CC
GO:0019882 antigen processing and presentation The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0019883 antigen processing and presentation of endogenous antigen The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. BP
GO:0019884 antigen processing and presentation of exogenous antigen The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex. BP
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. BP
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II The process by which an antigen-presenting cell expresses an peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. BP
GO:0019887 protein kinase regulator activity Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. MF
GO:0019888 protein phosphatase regulator activity Modulation of the activity of a protein phosphatase enzyme. MF
GO:0019889 pteridine metabolic process The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. BP
GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules. BP
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules. BP
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules. BP
GO:0002487 antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules. BP
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules. BP
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0002482 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0002483 antigen processing and presentation of endogenous peptide antigen The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. BP
GO:0002488 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. BP
GO:0047078 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate. MF
GO:0047079 pyrimidine-deoxynucleoside 1'-dioxygenase activity Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + dioxyribonolactone + uracil. MF
GO:0047072 2,3-dihydroxybenzoate 2,3-dioxygenase activity Catalysis of the reaction: O2 + 2,3-dihydroxybenzoate = 2-carboxy-cis,cis-muconate. MF
GO:0047073 2,4'-dihydroxyacetophenone dioxygenase activity Catalysis of the reaction: O2 + 2',4'-dihydroxyacetophenone = formate + p-hydroxybenzoate. MF
GO:0047070 3-carboxyethylcatechol 2,3-dioxygenase activity Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. MF
GO:0047071 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity Catalysis of the reaction: O2 + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate. MF
GO:0047076 methylphenyltetrahydropyridine N-monooxygenase activity Catalysis of the reaction: O2 + 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine = methanol + 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide. MF
GO:0047077 Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + pyrophosphate + AMP + CO2 + oxidized Photinus luciferin. MF
GO:0047074 4-hydroxycatechol 1,2-dioxygenase activity Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate. MF
GO:0047075 2,5-dihydroxypyridine 5,6-dioxygenase activity Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate. MF
GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. BP
GO:0006336 DNA replication-independent nucleosome assembly The formation of nucleosomes outside the context of DNA replication. BP
GO:0006337 nucleosome disassembly The disassembly of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. BP
GO:0006334 nucleosome assembly The aggregation and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. BP
GO:0006335 DNA replication-dependent nucleosome assembly The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. BP
GO:0018966 styrene metabolic process The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen. BP
GO:0018967 tetrachloroethylene metabolic process The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent. BP
GO:0042592 homeostatic process The biological processes involved in the maintenance of an internal equilibrium. BP
GO:0042593 glucose homeostasis Any of the processes involved in the maintenance of an internal equilibrium of glucose within an organism or cell. BP
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. BP
GO:0042596 fear response The response of an organism to a perceived external threat. BP
GO:0042597 periplasmic space The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi). CC
GO:0042594 response to starvation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. BP
GO:0042595 behavioral response to starvation A change in the behavior of an organism as a result of deprivation of nourishment. BP
GO:0042598 vesicular fraction Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized. CC
GO:0042599 lamellar body A membrane bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. CC
GO:0006480 N-terminal protein amino acid methylation The methylation of the N-terminal amino acid of a protein. BP
GO:0006481 C-terminal protein amino acid methylation The methylation of the C-terminal amino acid of a protein. BP
GO:0006482 protein amino acid demethylation NA BP
GO:0006486 protein amino acid glycosylation The addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. BP
GO:0006487 protein amino acid N-linked glycosylation The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine or the N1' atom peptidyl-tryptophan. BP
GO:0006488 dolichol-linked oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. BP
GO:0006489 dolichyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative. BP
GO:0050616 secologanin synthase activity Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O. MF
GO:0050617 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. MF
GO:0050614 delta24-sterol reductase activity Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. MF
GO:0050615 1,2-dihydrovomilenine reductase activity Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + NADPH + H+. MF
GO:0050612 arsenate reductase (donor) activity Catalysis of the reaction: acceptor + arsenite = donor-H2 + arsenate. MF
GO:0050613 delta14-sterol reductase activity Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. MF
GO:0050610 methylarsonate reductase activity Catalysis of the reaction: reduced glutathione + methylarsonate = oxidized glutathione + methylarsonite. MF
GO:0050611 arsenate reductase (azurin) activity Catalysis of the reaction: azurin(ox) + H2O + arsenite = azurin(red) + arsenate. MF
GO:0050618 phycoerythrobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin. MF
GO:0050619 phytochromobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. MF
GO:0005689 U12-dependent spliceosome The minor (U12-dependent) spliceosome is composed of the snRNPs, U11, U12, U4atac, U6atac, and U5 (which is also a component of the major spliceosome). This minor form of the spliceosome is responsible for the splicing of the majority of introns with atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. CC
GO:0005688 snRNP U6 Ribonucleoprotein complex containing small nuclear RNA U6; a component of the major spliceosome complex. CC
GO:0005687 snRNP U4 Ribonucleoprotein complex containing small nuclear RNA U4; a component of the major spliceosome complex. CC
GO:0005686 snRNP U2 Ribonucleoprotein complex containing small nuclear RNA U2; a component of the major spliceosome complex. CC
GO:0005685 snRNP U1 Ribonucleoprotein complex containing small nuclear RNA U1; a component of the major spliceosome complex. CC
GO:0005684 U2-dependent spliceosome The major (U2-dependent) spliceosome is composed of five snRNP complexes (U1, U2, U4, U5, and U6) as well as many non-snRNP proteins. It acts through many RNA-RNA, RNA-protein, and protein-protein interactions to precisely excise each intron and join the flanking exons. CC
GO:0005683 snRNP U7 A ribonucleoprotein complex, that includes the U7 snRNA, required for the 3'-end processing of replication-dependent histone pre-mRNAs. CC
GO:0005682 snRNP U5 Ribonucleoprotein complex containing small nuclear RNA U5; a component of both the major and minor spliceosome complexes. CC
GO:0005681 spliceosome A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. CC
GO:0005680 anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. CC
GO:0006875 metal ion homeostasis The regulation of the levels, transport, and metabolism of metal ions within a cell or between a cell and its external environment. BP
GO:0002303 gamma-delta T cell differentiation during immune response The process whereby an antigenically nave gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. BP
GO:0002302 CD8-positive, alpha-beta T cell differentiation during immune response The process whereby an antigenically nave CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. BP
GO:0002301 CD4-positive, alpha-beta intraepithelial T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. BP
GO:0002300 CD8-positive, alpha-beta intraepithelial T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. BP
GO:0002307 CD8-positive, alpha-beta regulatory T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell. BP
GO:0002306 CD4-positive gamma-delta intraepithelial T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. BP
GO:0002305 CD8-positive, gamma-delta intraepithelial T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. BP
GO:0002304 gamma-delta intraepithelial T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. BP
GO:0002309 T cell proliferation during immune response The rapid expansion of a T cell population by cell division during an immune response. BP
GO:0002308 CD8-positive, alpha-beta cytotoxic T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell. BP
GO:0004226 Gly-X carboxypeptidase activity Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa. MF
GO:0051056 regulation of small GTPase mediated signal transduction Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. BP
GO:0051055 negative regulation of lipid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. BP
GO:0051054 positive regulation of DNA metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. BP
GO:0051053 negative regulation of DNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. BP
GO:0051052 regulation of DNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. BP
GO:0051051 negative regulation of transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. BP
GO:0051050 positive regulation of transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. BP
GO:0051059 NF-kappaB binding Interacting selectively with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. MF
GO:0051058 negative regulation of small GTPase mediated signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction. BP
GO:0010137 ureide biosynthetic process The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots. BP
GO:0010136 ureide catabolic process The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium. BP
GO:0010135 ureide metabolic process The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants. BP
GO:0010134 sulfate assimilation via adenylyl sulfate reduction The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase. BP
GO:0010133 proline catabolic process to glutamate The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate. BP
GO:0010132 dhurrin biosynthetic process The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound. BP
GO:0010131 sucrose catabolic process using invertase or sucrose synthase The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase. BP
GO:0010130 anaerobic ethylbenzene catabolic process The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen. BP
GO:0010139 pyrimidine deoxyribonucleotide salvage The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis. BP
GO:0010138 pyrimidine ribonucleotide salvage The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis. BP
GO:0015437 lipopolysaccharide-transporting ATPase activity Catalysis of the reaction: ATP + H2O + lipopolysaccharide(in) = ADP + phosphate + lipopolysaccharide(out). MF
GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity Catalysis of the reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2. MF
GO:0001761 beta-alanine transporter activity Enables the directed movement of beta-alanine, 3-aminopropanoic acid, into, out of, within or between cells. MF
GO:0001762 beta-alanine transport The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of, within or between cells. BP
GO:0001763 morphogenesis of a branching structure The process by which the anatomical structures of branches are generated and organized. Morphogenesis pertains to the creation of form. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. BP
GO:0001764 neuron migration The characteristic movement of immature neurons from germinal zones to specific positions where they will reside as they mature. BP
GO:0001765 lipid raft formation Formation of tightly-packed gel-like membrane microdomains enriched in sphingolipids and cholesterol. BP
GO:0001766 lipid raft polarization The clustering and aggregation of lipid rafts at a single cellular pole during activation of particular cell types, such as lymphocytes. BP
GO:0001767 establishment of lymphocyte polarity The directed orientation of lymphocyte signaling molecules and associated lipid rafts towards a chemokine gradient or a contact point with an appropriate activating cell. BP
GO:0001768 establishment of T cell polarity The directed orientation of T cell signaling molecules and associated lipid rafts towards a chemokine gradient or a contact point with antigen presenting cell. BP
GO:0001769 establishment of B cell polarity The directed orientation of B cell signaling molecules and associated lipid rafts towards a chemokine gradient of a contact point with an antigen displaying cell. BP
GO:0015439 heme-transporting ATPase activity Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out). MF
GO:0015438 teichoic-acid-transporting ATPase activity Catalysis of the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out). MF
GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-glucosaminylamine + L-aspartate. MF
GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide. MF
GO:0052501 positive regulation by organism of apoptosis in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052502 positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. MF
GO:0003943 N-acetylgalactosamine-4-sulfatase activity Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. MF
GO:0003940 L-iduronidase activity Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in desulfated dermatan. MF
GO:0003941 L-serine ammonia-lyase activity Catalysis of the reaction: L-serine = pyruvate + NH3. MF
GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide. MF
GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. MF
GO:0003945 N-acetyllactosamine synthase activity Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. MF
GO:0019419 sulfate reduction NA BP
GO:0019418 sulfide oxidation NA BP
GO:0019413 acetate biosynthetic process The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. BP
GO:0019412 aerobic respiration, using hydrogen as electron donor The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water. BP
GO:0019411 aerobic respiration, using ferrous ions as electron donor NA BP
GO:0019410 aerobic respiration, using carbon monoxide as electron donor NA BP
GO:0019417 sulfur oxidation The addition of oxygen to elemental sulfur. BP
GO:0019416 polythionate oxidation NA BP
GO:0019415 acetate biosynthetic process from carbon monoxide The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide. BP
GO:0019414 aerobic respiration, using sulfur or sulfate as electron donor NA BP
GO:0042839 D-glucuronate metabolic process The chemical reactions and pathways involving D-glucuronate, the dextrorotatory isomer of glucuronate. BP
GO:0042838 D-glucarate catabolic process The chemical reactions and pathways resulting in the breakdown of D-glucarate, the dextrorotatory isomer of glucarate. BP
GO:0042832 defense response to protozoan Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism. BP
GO:0042835 BRE binding Interacting selectively with the RNA element BRE (Bruno response element). MF
GO:0042834 peptidoglycan binding Interacting selectively, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. MF
GO:0042837 D-glucarate biosynthetic process The chemical reactions and pathways resulting in the formation of D-glucarate, the dextrorotatory isomer of glucarate. BP
GO:0042836 D-glucarate metabolic process The chemical reactions and pathways involving D-glucarate, the dextrorotatory isomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose. BP
GO:0048082 regulation of adult cuticle pigmentation Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. BP
GO:0048083 negative regulation of adult cuticle pigmentation Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. BP
GO:0048080 negative regulation of cuticle pigmentation Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. BP
GO:0008940 nitrate reductase activity Catalysis of the reaction: NO2- (nitrite) + acceptor = NO3- (nitrate) + reduced acceptor. MF
GO:0048086 negative regulation of pigmentation Any process that stops, prevents or reduces the rate or extent of color pattern formation in an organ or organism. BP
GO:0048087 positive regulation of pigmentation Any process that activates or increases the rate or extent of color pattern formation in an organ or organism. BP
GO:0000411 positive regulation of transcription by galactose Any process involving galactose that activates or increases the rate of transcription. BP
GO:0000410 negative regulation of transcription by galactose NA BP
GO:0000413 protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue. BP
GO:0000412 histone peptidyl-prolyl isomerization The modification of a histone by cis-trans isomerization of a proline residue. BP
GO:0000415 negative regulation of histone H3-K36 methylation Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. BP
GO:0006921 cell structure disassembly during apoptosis The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. BP
GO:0000417 HIR complex A protein complex proposed to be involved in replication-indepdent chromatin assembly. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p. CC
GO:0000416 positive regulation of histone H3-K36 methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. BP
GO:0000419 DNA-directed RNA polymerase IVb complex RNA polymerase IVb is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensu thes sequence as well as other sequences. The remainder of the complex is composed of smaller subunits. CC
GO:0000418 DNA-directed RNA polymerase IV complex RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The IVa and IVb complexes contain different forms of the largest subunit. The remainder of the complex is composed of smaller subunits. CC
GO:0048085 adult cuticle pigmentation Establishment of the adult pattern of pigmentation in the cuticle of an organism. BP
GO:0008949 oxalyl-CoA decarboxylase activity Catalysis of the reaction: oxalyl-CoA = formyl-CoA + CO2. MF
GO:0048089 regulation of female pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females. BP
GO:0005605 basal lamina A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. CC
GO:0051732 polyribonucleotide kinase activity Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA. MF
GO:0051733 polydeoxyribonucleotide kinase activity Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA. MF
GO:0051730 GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA. MF
GO:0051731 polynucleotide kinase activity Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. MF
GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA. MF
GO:0051737 GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA. MF
GO:0051734 ATP-dependent polynucleotide kinase activity Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. MF
GO:0051735 GTP-dependent polynucleotide kinase activity Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. MF
GO:0051738 xanthophyll binding Interacting selectively with xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen. MF
GO:0051739 ammonia transporter activity Enables the directed movement of ammonia into, out of, within or between cells. MF
GO:0051884 regulation of anagen Any process that modulates the frequency, rate or extent of anagen, the growth phase of the hair cycle. BP
GO:0051885 positive regulation of anagen Any process that activates or increases the frequency, rate or extent of anagen, the growth phase of the hair cycle. BP
GO:0051886 negative regulation of anagen Any process that stops, prevents or reduces the frequency, rate or extent of anagen, the growth phase of the hair cycle. BP
GO:0051887 regulation of exogen Any process that modulates the frequency, rate or extent of exogen, the shedding phase of the hair cycle. BP
GO:0051880 G-quadruplex DNA binding Interacting selectively with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. MF
GO:0051881 regulation of mitochondrial membrane potential Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. BP
GO:0051882 mitochondrial depolarization The process in which the membrane potential of the mitochondria changes in the depolarizing direction from the resting potential, from negative to positive. BP
GO:0051883 killing of cells in other organism during symbiotic interaction Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051888 positive regulation of exogen Any process that activates or increases the frequency, rate or extent of exogen, the shedding phase of the hair cycle. BP
GO:0051889 negative regulation of exogen Any process that stops, prevents or reduces the frequency, rate or extent of exogen, the shedding phase of the hair cycle. BP
GO:0052283 modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052282 negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052281 negative regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052280 negative regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052287 positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of calcium-dependent protein kinase pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052286 induction by organism of resistance gene-dependent defense response of other organism during symbiotic interaction The activation by an organism of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052285 modulation by organism of defense-related callose deposition of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052284 modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052289 induction by organism of systemic acquired resistance in other organism during symbiotic interaction Any process by which an organism activates systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052288 induction by organism of induced systemic resistance in other organism during symbiotic interaction Any process by which an organism activates induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0008767 UDP-galactopyranose mutase activity Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose. MF
GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. MF
GO:0008765 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate. MF
GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. MF
GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. MF
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. MF
GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. MF
GO:0008760 UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. MF
GO:0008769 X-His dipeptidase activity Catalysis of the hydrolysis of Xaa-His dipeptides. MF
GO:0008768 UDP-sugar diphosphatase activity Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. MF
GO:0047727 isobutyryl-CoA mutase activity Catalysis of the reaction: 2-methylpropanoyl-CoA = butanoyl-CoA. MF
GO:0052495 occlusion by organism of vascular system in other organism during symbiotic interaction The process by which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction. BP
GO:0005725 intercalary heterochromatin Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes. CC
GO:0015300 solute:solute antiporter activity Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out). MF
GO:0042740 exogenous antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism. BP
GO:0048818 positive regulation of hair follicle maturation Any process that activates or increases the frequency, rate or extent of hair follicle maturation. BP
GO:0016167 glial cell line-derived neurotrophic factor receptor activity NA MF
GO:0047502 (+)-sabinol dehydrogenase activity Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (+)-sabinone + NADH + H+. MF
GO:0047503 (-)-borneol dehydrogenase activity Catalysis of the reaction: (-)-borneol + NAD+ = (-)-camphor + NADH + H+. MF
GO:0047500 (+)-borneol dehydrogenase activity Catalysis of the reaction: (+)-borneol + NAD+ = (+)-camphor + NADH + H+. MF
GO:0047501 (+)-neomenthol dehydrogenase activity Catalysis of the reaction: (+)-neomenthol + NADP+ = (-)-menthone + NADPH + H+. MF
GO:0047506 (deoxy)adenylate kinase activity Catalysis of the reaction: ATP + dAMP = ADP + dADP. MF
GO:0047507 (deoxy)nucleoside-phosphate kinase activity Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate. MF
GO:0047504 (-)-menthol dehydrogenase activity Catalysis of the reaction: (-)-menthol + NADP+ = (-)-menthone + NADPH + H+. MF
GO:0047505 (-)-menthol monooxygenase activity Catalysis of the reaction: (-)-menthol + NADPH + H+ + O2 = p-menthane-3,8-diol + NADP+ + H2O. MF
GO:0047508 (R)-2-methylmalate dehydratase activity Catalysis of the reaction: (R)-2-methylmalate = 2-methylmaleate + H2O. MF
GO:0047509 (R)-dehydropantoate dehydrogenase activity Catalysis of the reaction: (R)-4-dehydropantoate + NAD+ + H2O = (R)-3,3-dimethylmalate + NADH + H+. MF
GO:0043212 carbohydrate-exporting ATPase activity Catalysis of the reaction: ATP + H2O + carbohydrate(in) = ADP + phosphate + carbohydrate(out). MF
GO:0043213 bacteriocin transport The directed movement of a bacteriocin into, out of, within or between cells. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain. BP
GO:0043210 alkanesulfonate binding Interacting selectively with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety. MF
GO:0043211 carbohydrate-transporting ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of carbohydrates across a membrane. MF
GO:0043216 daunorubicin-transporting ATPase activity Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out). MF
GO:0043217 myelin maintenance The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. BP
GO:0043214 bacteriocin-transporting ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane. MF
GO:0043215 daunorubicin transport The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of, within or between cells. BP
GO:0043218 compact myelin The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. CC
GO:0043219 lateral loop Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode. CC
GO:0047402 protein-glucosylgalactosylhydroxylysine glucosidase activity Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. MF
GO:0046457 prostanoid biosynthetic process The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. BP
GO:0046456 icosanoid biosynthetic process The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. BP
GO:0046455 organosilicon catabolic process The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon. BP
GO:0046454 dimethylsilanediol metabolic process The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. BP
GO:0046453 dipyrrin metabolic process The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group. BP
GO:0046452 dihydrofolate metabolic process The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate. BP
GO:0046451 diaminopimelate metabolic process The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. BP
GO:0046450 dethiobiotin metabolic process The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms. BP
GO:0046459 short-chain fatty acid metabolic process The chemical reactions and pathways involving fatty acids with a chain length of less than 8 carbons. BP
GO:0046458 hexadecanal metabolic process The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde. BP
GO:0045904 negative regulation of translational termination Any process that stops, prevents or reduces the frequency, rate or extent of translational termination. BP
GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. BP
GO:0045906 negative regulation of vasoconstriction Any process that stops, prevents or reduces the frequency, rate or extent of vasoconstriction. BP
GO:0045907 positive regulation of vasoconstriction Any process that activates or increases the frequency, rate or extent of vasoconstriction. BP
GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. BP
GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. BP
GO:0045902 negative regulation of translational fidelity Any process that stops, prevents or reduces the frequency, rate or extent of activities to ensure translational fidelity. BP
GO:0045903 positive regulation of translational fidelity Any process that activates or increases the frequency, rate or extent of activities to ensure translational fidelity. BP
GO:0045908 negative regulation of vasodilation Any process that stops, prevents or reduces the frequency, rate or extent of vasodilation. BP
GO:0045909 positive regulation of vasodilation Any process that activates or increases the frequency, rate or extent of vasodilation. BP
GO:0005751 respiratory chain complex IV (sensu Eukaryota) A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Found in eukaryotes. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0048920 posterior lateral line neuromast primordium migration The migration of a cluster of relatively undifferentiated cells along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. BP
GO:0005753 proton-transporting ATP synthase complex (sensu Eukaryota) The complex that catalyzes the phosphorylation of ADP to ATP in mitochondria, during oxidative phosphorylation; it catalyzes the hydrolysis of ATP to ADP and orthophosphate. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0015227 acyl carnitine transporter activity Enables the directed movement of acyl carnitine into, out of, within or between cells. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. MF
GO:0005754 proton-transporting ATP synthase, catalytic core (sensu Eukaryota) The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0010121 arginine catabolic process to proline via ornithine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine. BP
GO:0005757 mitochondrial permeability transition pore NA CC
GO:0005756 proton-transporting ATP synthase, central stalk (sensu Eukaryota) One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated F0 proteins; rotates within the catalytic core during catalysis. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0005759 mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty-acid oxidation. CC
GO:0005758 mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope. CC
GO:0048507 meristem development The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. BP
GO:0048506 regulation of timing of meristematic phase transition The process controlling the point in time during development when a meristem will change its identity, and/or the rate at which the change occurs. BP
GO:0048505 regulation of timing of cell differentiation The process controlling the timing and/or rate at which relatively unspecialized cells acquire specialized features. BP
GO:0048504 regulation of timing of organ formation The process controlling the point in time during development when an organ will form, and/or the rate at which organ formation occurs. BP
GO:0048503 GPI anchor binding Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. MF
GO:0048502 thiamin-transporting ATPase activity Catalysis of the reaction: ATP + H2O + thiamin(out) = ADP + phosphate + thiamin(in). MF
GO:0048501 signal recognition particle (sensu Bacteria and Archaea) A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. CC
GO:0048509 regulation of meristem development Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. BP
GO:0048508 embryonic meristem development The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure. BP
GO:0030568 plasmin inhibitor activity Stops, prevents or reduces the activity of the serine endopeptidase plasmin. MF
GO:0030569 chymotrypsin inhibitor activity Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin. MF
GO:0030562 rRNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030563 snRNA 2'-O-ribose methylation guide activity Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule. MF
GO:0030560 tRNA pseudouridylation guide activity Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030561 RNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030566 snRNA modification guide activity Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030567 prothrombin activator activity Increases the rate of proteolysis catalyzed by thrombin. MF
GO:0030564 tRNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue. MF
GO:0030565 snRNA pseudouridylation guide activity Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule. MF
GO:0005047 signal recognition particle binding Interacting selectively with the signal recognition particle. MF
GO:0009159 deoxyribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009158 ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009156 ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009155 purine deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009154 purine ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009153 purine deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009152 purine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009151 purine deoxyribonucleotide metabolic process The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009150 purine ribonucleotide metabolic process The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0005046 KDEL sequence binding Interacting selectively with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. MF
GO:0005041 low-density lipoprotein receptor activity Combining with a low-density lipoprotein to initiate a change in cell activity. MF
GO:0005040 decoy death receptor activity NA MF
GO:0005043 repulsive netrin receptor activity A transmembrane receptor activity that responds to the netrin family of ligands and results in chemorepulsion when activated. MF
GO:0005289 high-affinity arginine transporter activity NA MF
GO:0005288 arginine permease activity Catalysis of the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane. MF
GO:0008208 C21-steroid hormone catabolic process The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. BP
GO:0008209 androgen metabolic process The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. BP
GO:0005042 netrin receptor activity A transmembrane receptor activity that responds to the netrin family of ligands and results in chemotaxis when activated. MF
GO:0008204 ergosterol metabolic process The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light. BP
GO:0008205 ecdysone metabolic process The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development. BP
GO:0008206 bile acid metabolic process The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. BP
GO:0008207 C21-steroid hormone metabolic process The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. BP
GO:0008200 ion channel inhibitor activity NA MF
GO:0008201 heparin binding Interacting selectively with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. MF
GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. BP
GO:0008203 cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. BP
GO:0005283 sodium:amino acid symporter activity Catalysis of the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). MF
GO:0005280 hydrogen:amino acid symporter activity Catalysis of the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). MF
GO:0005287 high-affinity basic amino acid transporter activity NA MF
GO:0005286 basic amino acid permease activity Catalysis of the stereospecific transfer of basic amino acids, amino acids with a pH greater than 7, across a biological membrane. MF
GO:0005284 insulin-activated sodium:amino acid symporter activity NA MF
GO:0002563 somatic diversification of immune receptors via alternate splicing The process by which immune receptor genes are diversified through alternate splicing. BP
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. BP
GO:0002561 basophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil. BP
GO:0002560 basophil mediated immunity Any process involved in the carrying out of an immune response by a mast cell. BP
GO:0002567 somatic diversification of FREP-based immune receptors The process by means of which sequence diversity of the FREP-based immune receptors of snails is generated. BP
GO:0002566 somatic diversification of immune receptors via somatic mutation The process by which immune receptor genes are diversified through somatic mutation. BP
GO:0002565 somatic diversification of immune receptors via gene conversion The process by which immune receptor genes are diversified through gene conversion. BP
GO:0002564 alternate splicing of immunoglobulin genes The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons. BP
GO:0002569 somatic diversification of immune receptors by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene. BP
GO:0002568 somatic diversification of T cell receptor genes The somatic process by means of which sequence diversity of T cell receptor genes is generated. BP
GO:0032681 regulation of tumor necrosis factor-beta production Any process that modulates the frequency, rate, or extent of tumor necrosis factor-beta production. BP
GO:0032680 regulation of tumor necrosis factor-alpha production Any process that modulates the frequency, rate, or extent of tumor necrosis factor-alpha production. BP
GO:0032683 negative regulation of connective tissue growth factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production. BP
GO:0032682 negative regulation of chemokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. BP
GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. BP
GO:0032684 negative regulation of fractalkine production Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production. BP
GO:0032687 negative regulation of interferon-alpha production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production. BP
GO:0032686 negative regulation of hepatocyte growth factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production. BP
GO:0032689 negative regulation of interferon-gamma production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. BP
GO:0032688 negative regulation of interferon-beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production. BP
GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. BP
GO:0042259 peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine The posttranslation modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12. BP
GO:0042258 molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide. BP
GO:0042251 maintenance of polarity of larval imaginal disc epithelium The maintenance of an established polarized larval imaginal disc epithelium. BP
GO:0042250 maintenance of polarity of embryonic epithelium The maintenance of an established polarized embryonic epithelial sheet. BP
GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages. BP
GO:0042252 establishment of polarity of larval imaginal disc epithelium The specification and formation of a polarized larval imaginal disc epithelium. BP
GO:0042255 ribosome assembly The aggregation and bonding together of the mature ribosome and of its subunits. BP
GO:0042254 ribosome biogenesis and assembly The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. BP
GO:0042257 ribosomal subunit assembly The assembly of the ribosomal subunits from their constituent components. BP
GO:0042256 mature ribosome assembly The assembly of the large and small ribosomal subunits into a functional ribosome. BP
GO:0003779 actin binding Interacting selectively with monomeric or multimeric forms of actin, including actin filaments. MF
GO:0003774 motor activity Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. MF
GO:0003777 microtubule motor activity Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). MF
GO:0000235 astral microtubule Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. CC
GO:0000234 phosphoethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. MF
GO:0000237 leptotene Progression through the first stage of prophase I in meiosis, in which chromosomes first become visible. BP
GO:0000236 mitotic prometaphase Progression through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. BP
GO:0000239 pachytene Progression through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome. BP
GO:0000238 zygotene Progression through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur. BP
GO:0004921 interleukin-11 receptor activity Combining with interleukin-11 to initiate a change in cell activity. MF
GO:0004920 interleukin-10 receptor activity Combining with interleukin-10 to initiate a change in cell activity. MF
GO:0004923 leukemia inhibitory factor receptor activity Combining with leukemia inhibitory factor to initiate a change in cell activity. MF
GO:0004925 prolactin receptor activity Combining with prolactin to initiate a change in cell activity. MF
GO:0004924 oncostatin-M receptor activity Combining with oncostatin-M to initiate a change in cell activity. MF
GO:0004926 non-G-protein coupled 7TM receptor activity NA MF
GO:0006691 leukotriene metabolic process The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. BP
GO:0006690 icosanoid metabolic process The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. BP
GO:0006693 prostaglandin metabolic process The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. BP
GO:0006692 prostanoid metabolic process The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. BP
GO:0006695 cholesterol biosynthetic process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. BP
GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. BP
GO:0006697 ecdysone biosynthetic process The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. BP
GO:0006696 ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. BP
GO:0006699 bile acid biosynthetic process The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. BP
GO:0005346 purine ribonucleotide transporter activity Enables the directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell. MF
GO:0005347 ATP transporter activity Enables the directed movement of ATP, adenosine triphosphate, into, out of, within or between cells. MF
GO:0005344 oxygen transporter activity Enables the directed movement of oxygen into, out of, within or between cells. MF
GO:0005345 purine transporter activity Enables the directed movement of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells. MF
GO:0005342 organic acid transporter activity Enables the directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells. MF
GO:0005343 organic acid:sodium symporter activity Catalysis of the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). MF
GO:0005340 nucleotide-sulfate transporter activity NA MF
GO:0004699 calcium-independent protein kinase C activity NA MF
GO:0004698 calcium-dependent protein kinase C activity NA MF
GO:0004693 cyclin-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). MF
GO:0004692 cGMP-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cGMP. MF
GO:0004691 cAMP-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cAMP. MF
GO:0004690 cyclic nucleotide-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a cyclic nucleotide. MF
GO:0004697 protein kinase C activity NA MF
GO:0004696 glycogen synthase kinase 3 activity NA MF
GO:0004695 galactosyltransferase-associated kinase activity NA MF
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity NA MF
GO:0051152 positive regulation of smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. BP
GO:0051153 regulation of striated muscle cell differentiation Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. BP
GO:0051150 regulation of smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. BP
GO:0051151 negative regulation of smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle cell differentiation. BP
GO:0051156 glucose 6-phosphate metabolic process The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. BP
GO:0051157 arabitol catabolic process The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. BP
GO:0051154 negative regulation of striated muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle cell differentiation. BP
GO:0051155 positive regulation of striated muscle cell differentiation Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. BP
GO:0051158 L-arabitol catabolic process The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. BP
GO:0051159 D-arabitol catabolic process The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. BP
GO:0010072 primary shoot apical meristem specification The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers. BP
GO:0010073 meristem maintenance The processes involved in maintaining the identity, size and shape of a meristem. BP
GO:0010070 zygote asymmetric cell division The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. BP
GO:0010071 root meristem specification The specification of a meristem which will give rise to a primary or lateral root. BP
GO:0010076 maintenance of floral meristem identity The processes involved in maintaining the identity of a floral meristem. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010077 maintenance of inflorescence meristem identity The processes involved in maintaining the identity of an inflorescence meristem. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010074 maintenance of meristem identity The process by which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. BP
GO:0010075 regulation of meristem size The processes involved in maintaining the size and shape of a meristem. BP
GO:0010078 maintenance of root meristem identity The processes involved in maintaining the identity of a root meristem. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0010079 maintenance of vegetative meristem identity The processes involved in maintaining the identity of a vegetative meristem. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0018241 protein amino acid O-linked glycosylation via hydroxylysine The posttranslational glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine. BP
GO:0018240 protein amino acid S-linked glycosylation via cysteine The posttranslational glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine. BP
GO:0018243 protein amino acid O-linked glycosylation via threonine The posttranslational glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine. BP
GO:0018242 protein amino acid O-linked glycosylation via serine The posttranslational glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine. BP
GO:0018245 protein amino acid O-linked glycosylation via tyrosine The posttranslational glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen. BP
GO:0018244 protein amino acid N-linked glycosylation via tryptophan The posttranslational glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; it is uncertain whether this is an N-glycoside linkage (as indicated), and which particular hexose is involved. BP
GO:0018247 protein-phosphoribosyl dephospho-coenzyme A linkage The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position. BP
GO:0018246 protein-coenzyme A linkage NA BP
GO:0018249 protein amino acid dehydration The removal of a water group from a protein amino acid. BP
GO:0018248 enzyme active site formation via S-sulfo-L-cysteine The transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine. BP
GO:0019596 mandelate catabolic process The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. BP
GO:0019597 (R)-mandelate catabolic process to benzoate The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate. BP
GO:0019594 mannitol metabolic process The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. BP
GO:0019595 non-phosphorylated glucose catabolic process The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose. BP
GO:0019592 mannitol catabolic process The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. BP
GO:0019593 mannitol biosynthetic process The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. BP
GO:0019590 L-arabitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. BP
GO:0019591 arabitol utilization NA BP
GO:0019598 (R)-mandelate catabolic process to catechol The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol. BP
GO:0019599 (R)-4-hydroxymandelate catabolic process The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid. BP
GO:0007278 pole cell fate determination Process by which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0007279 pole cell formation Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells. BP
GO:0007270 nerve-nerve synaptic transmission The process of communication from a neuron to another neuron across a synapse. BP
GO:0007271 synaptic transmission, cholinergic The process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. BP
GO:0007272 ensheathment of neurons The process whereby glial cells envelop neuronal cell bodies and/or axons to form and insulating layer. This can take the form of myelinating or non-myelinating ensheathment. BP
GO:0007274 neuromuscular synaptic transmission The process of communication from a neuron to a muscle, across a synapse. BP
GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). BP
GO:0007276 gametogenesis The generation and maintenance of gametes. BP
GO:0007277 pole cell development The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure. BP
GO:0021869 forebrain ventricular zone progenitor cell division The mitotic division of a basal progenitor giving rise to two neurons. BP
GO:0021868 ventricular zone cell-producing asymmetric radial glial cell division in the forebrain The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell. BP
GO:0021865 symmetric radial glial cell division in the forebrain The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain. BP
GO:0021864 radial glial cell division in the forebrain The mitotic division of radial glial cells in the developing forebrain. BP
GO:0021867 neuron-producing asymmetric radial glial cell division in the forebrain The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor. BP
GO:0021866 asymmetric radial glial cell division in the forebrain The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type. BP
GO:0021861 radial glial cell differentiation in the forebrain The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021860 pyramidal neuron development The progression of a pyramidal neuron from its initial formation to its mature state. BP
GO:0021863 neuroblast cell differentiation The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblast that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021862 early neuron differentiation in the forebrain The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0016029 subrhabdomeral cisterna The internal stores of calcium found at the base of the rhabdomere. CC
GO:0016028 rhabdomere The specialized microvillar organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction. CC
GO:0016023 cytoplasmic membrane-bound vesicle A membrane-bound vesicle found in the cytoplasm of the cell. CC
GO:0016022 endoplasmic reticulum cisterna The flattened sac-like space enclosed between paired membrane of the endoplasmic reticulum. CC
GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. CC
GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. CC
GO:0016027 inaD signaling complex A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD. CC
GO:0016024 CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. BP
GO:0019628 urate catabolic process The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine. BP
GO:0019629 propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle. BP
GO:0019620 aerobic benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen. BP
GO:0019621 creatinine catabolic process to formate The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate. BP
GO:0019622 3-(3-hydroxy)phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. BP
GO:0019623 atrazine catabolic process to urea The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea. BP
GO:0019624 atrazine catabolic process to isopropylamine The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine. BP
GO:0019625 atrazine catabolic process to cyanuric acid The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid. BP
GO:0019626 short-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than 8 carbons. BP
GO:0019627 urea metabolic process The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals. BP
GO:0042699 follicle-stimulating hormone signaling pathway The series of molecular signals mediated by follicle-stimulating hormone. BP
GO:0042698 menstrual cycle The type of sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. BP
GO:0004325 ferrochelatase activity Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+. MF
GO:0031767 gastric inhibitory polypeptide receptor binding Interacting selectively with a gastric inhibitory polypeptide receptor. MF
GO:0031766 type 3 galanin receptor binding Interacting selectively with a type 3 galanin receptor. MF
GO:0031765 type 2 galanin receptor binding Interacting selectively with a type 2 galanin receptor. MF
GO:0031764 type 1 galanin receptor binding Interacting selectively with a type 1 galanin receptor. MF
GO:0031763 galanin receptor binding Interacting selectively with a galanin receptor. MF
GO:0031762 follicle stimulating hormone receptor binding Interacting selectively with a follicle stimulating hormone receptor. MF
GO:0031761 fMet-Leu-Phe receptor binding Interacting selectively with a fMet-Leu-Phe receptor. MF
GO:0031760 Edg-7 lysophosphatidic acid receptor binding Interacting selectively with an Edg-7 lysophosphatidic acid receptor. MF
GO:0031769 glucagon receptor binding Interacting selectively with a glucagon receptor. MF
GO:0031768 ghrelin receptor binding Interacting selectively with a ghrelin receptor. MF
GO:0015822 ornithine transport The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of, within or between cells. BP
GO:0015823 phenylalanine transport The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of, within or between cells. BP
GO:0015820 leucine transport The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of, within or between cells. BP
GO:0015821 methionine transport The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of, within or between cells. BP
GO:0015826 threonine transport The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of, within or between cells. BP
GO:0015827 tryptophan transport The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of, within or between cells. BP
GO:0015824 proline transport The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of, within or between cells. BP
GO:0015825 L-serine transport The directed movement of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells. BP
GO:0021658 rhombomere 3 morphogenesis The process by which the anatomical structure of rhombomere 3 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0015828 tyrosine transport The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of, within or between cells. BP
GO:0015829 valine transport The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of, within or between cells. BP
GO:0042693 muscle cell fate commitment The process by which the cellular identity of muscle cells is acquired and determined. BP
GO:0042692 muscle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell. BP
GO:0042695 thelarche The beginning of development of the breasts in the female. BP
GO:0042694 muscle cell fate specification Process by which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0051963 regulation of synaptogenesis Any process that modulates the frequency, rate or extent of synaptogenesis, the formation of a synapse. BP
GO:0051962 positive regulation of nervous system development Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. BP
GO:0051961 negative regulation of nervous system development Any process that stops, prevents or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. BP
GO:0051960 regulation of nervous system development Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. BP
GO:0051967 negative regulation of synaptic transmission, glutamatergic Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. BP
GO:0017087 mitochondrial processing peptidase complex This enzyme complex catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion. CC
GO:0017084 delta1-pyrroline-5-carboxylate synthetase activity NA MF
GO:0051964 negative regulation of synaptogenesis Any process that stops, prevents or reduces the frequency, rate or extent of synaptogenesis, the formation of a synapse. BP
GO:0051969 regulation of transmission of nerve impulse Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. BP
GO:0051968 positive regulation of synaptic transmission, glutamatergic Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. BP
GO:0009319 cytochrome o ubiquinol oxidase complex A bacterial heterooctameric enzyme composed of two A chains, two B chains, two C chains and two D chains. Possesses cytochrome o ubiquinol oxidase activity. CC
GO:0009318 exodeoxyribonuclease VII complex An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. CC
GO:0044265 cellular macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. BP
GO:0009314 response to radiation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. BP
GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. CC
GO:0009316 3-isopropylmalate dehydratase complex A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. CC
GO:0009311 oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. BP
GO:0009310 amine catabolic process The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. BP
GO:0009313 oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. BP
GO:0009312 oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. BP
GO:0008043 ferritin complex A iron-storing protein complex, which in humans has 24 subunits. There are two different ferritin subunits, the L (light) chain and H (heavy) chain. CC
GO:0008046 axon guidance receptor activity NA MF
GO:0008047 enzyme activator activity Increases the activity of an enzyme. MF
GO:0008045 motor axon guidance The process by which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. BP
GO:0005218 intracellular ligand-gated calcium channel activity NA MF
GO:0008048 calcium sensitive guanylate cyclase activator activity NA MF
GO:0008049 male courtship behavior The actions or reactions of a male, for the purpose of attracting a sexual partner. BP
GO:0048609 reproductive process in a multicellular organism The process, occurring above the cellular level, that is pertinent to the reproductive function of an organism. This includes the integrated processes at the level of tissues and organs. BP
GO:0016844 strictosidine synthase activity Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. MF
GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. MF
GO:0016846 carbon-sulfur lyase activity Catalysis of the elimination of H2S or substituted H2S. MF
GO:0016841 ammonia-lyase activity Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. MF
GO:0016840 carbon-nitrogen lyase activity Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). MF
GO:0016843 amine-lyase activity Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate. MF
GO:0016842 amidine-lyase activity Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. MF
GO:0016849 phosphorus-oxygen lyase activity NA MF
GO:0016848 carbon-halide lyase activity Catalysis of the breakage of a bond between carbon and any halogen atom. MF
GO:0005214 structural constituent of cuticle (sensu Insecta) The action of a molecule that contributes to the structural integrity of a cuticle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). MF
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. MF
GO:0005216 ion channel activity Allows the regulatable energy-independent passage of ions across a lipid bilayer down a concentration gradient. MF
GO:0005217 intracellular ligand-gated ion channel activity NA MF
GO:0008594 photoreceptor cell morphogenesis (sensu Endopterygota) Morphogenesis of photoreceptors, sensory cells that react to the presence of light. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0008595 determination of anterior/posterior axis, embryo The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. BP
GO:0045379 negative regulation of interleukin-17 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17. BP
GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. MF
GO:0008590 regulation of frizzled signaling pathway Any process that modulates the frequency, rate or extent of the frizzled signaling pathway. BP
GO:0048602 fibroblast growth factor 1 binding Interacting selectively with fibroblast growth factor 1. MF
GO:0008592 regulation of Toll signaling pathway Any process that modulates the frequency, rate or extent of the Tl signaling pathway. BP
GO:0008593 regulation of Notch signaling pathway Any process that modulates the frequency, rate or extent of the Notch signaling pathway. BP
GO:0045373 negative regulation of interleukin-15 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15. BP
GO:0045372 regulation of interleukin-15 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15. BP
GO:0045371 positive regulation of interleukin-14 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14. BP
GO:0048603 fibroblast growth factor 2 binding Interacting selectively with fibroblast growth factor 2. MF
GO:0045377 positive regulation of interleukin-16 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16. BP
GO:0008599 protein phosphatase type 1 regulator activity Modulation of the activity of the enzyme protein phosphatase type 1. MF
GO:0045375 regulation of interleukin-16 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16. BP
GO:0045374 positive regulation of interleukin-15 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15. BP
GO:0032447 protein urmylation Covalent attachment of the ubiquitin-like protein URM1 to another protein. BP
GO:0032446 protein modification by small protein conjugation A process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. BP
GO:0032445 fructose import The directed movement of the hexose monosaccharide fructose into a cell or organelle. BP
GO:0032444 activin responsive factor complex A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor. CC
GO:0032443 regulation of ergosterol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. BP
GO:0032442 phenylcoumaran benzylic ether reductase activity Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction dehydrodiconiferyl alcohol + NADPH = isodihydrodehydrodiconiferyl alcohol + NADP. MF
GO:0032441 pheophorbide a oxygenase activity Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite (RCC) + oxidized ferredoxin + H2O. MF
GO:0032440 2-alkenal reductase activity Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+. MF
GO:0032449 CBM complex A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation. CC
GO:0032448 DNA hairpin binding Interacting selectively with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences. MF
GO:0021654 rhombomere boundary formation The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0015013 heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan. BP
GO:0015012 heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. BP
GO:0015011 nickel-tetrapyrrole coenzyme metabolic process The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430cofactor found in methyl-coenzyme M reductase. BP
GO:0015010 tetrahydrocorphin metabolic process The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins. BP
GO:0047209 coniferyl-alcohol glucosyltransferase activity Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP. MF
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-desulfoheparin = adenosine 3',5'-bisphosphate + heparin. MF
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. BP
GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan. BP
GO:0047205 quinate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA. MF
GO:0047204 chlorogenate-glucarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: D-glucarate + chlorogenate = 2-O-caffeoylglucarate + quinate. MF
GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide. MF
GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. MF
GO:0047201 beta-glucogallin O-galloyltransferase activity Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1-O,6-O-digalloyl-beta-D-glucose + beta-D-glucose. MF
GO:0047200 tetrahydrodipicolinate N-acetyltransferase activity Catalysis of the reaction: L-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA = L-2-acetamido-6-oxoheptanedioate + CoA. MF
GO:0047203 13-hydroxylupinine O-tigloyltransferase activity Catalysis of the reaction: 13-hydroxylupinine + (E)-2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyl)oxylupinine + CoA. MF
GO:0047202 sinapoylglucose-choline O-sinapoyltransferase activity Catalysis of the reaction: choline + 1-O-sinapoyl-beta-D-glucose = O-sinapoylcholine + beta-D-glucose. MF
GO:0046552 photoreceptor cell fate commitment The process during which a photoreceptor, a cell that responds to incident electromagnetic radiation, commit to their cell fate. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. BP
GO:0046553 D-malate dehydrogenase (decarboxylating) activity Catalysis of the reaction: (R)-malate + NAD+ = pyruvate + CO2 + NADH + H+. MF
GO:0046550 (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7. BP
GO:0046551 retinal cone cell fate commitment The process during which the cone cells of the eye adopt pathways of differentiation that lead to the establishment of their distinct cell type. BP
GO:0046556 alpha-N-arabinofuranosidase activity Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. MF
GO:0046557 glucan endo-1,6-beta-glucosidase activity Catalysis of the random hydrolysis of 1,6-linkages in 1,6-beta-D-glucans. MF
GO:0046554 malate dehydrogenase (NADP+) activity Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. MF
GO:0046555 acetylxylan esterase activity Catalysis of the deacetylation of xylans and xylo-oligosaccharides. MF
GO:0046558 arabinan endo-1,5-alpha-L-arabinosidase activity Catalysis of the endohydrolysis of 1,5-alpha-arabinofuranosidic linkages in 1,5-arabinans. MF
GO:0046559 alpha-glucuronidase activity Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate. MF
GO:0035259 glucocorticoid receptor binding Interacting selectively with a glucocorticoid receptor. MF
GO:0035258 steroid hormone receptor binding Interacting selectively with a steroid hormone receptor. MF
GO:0035253 ciliary rootlet A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. CC
GO:0035252 UDP-xylosyltransferase activity Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. MF
GO:0035251 UDP-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. MF
GO:0035250 UDP-galactosyltransferase activity Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. MF
GO:0035257 nuclear hormone receptor binding Interacting selectively with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell. MF
GO:0035256 metabotropic glutatmate receptor binding Interacting selectively with a metabotropic glutamate receptor. Metabotropic glutamate receptors are G-protein coupled receptors that bind glutamate and exert an effect through the regulation of enzyme activity. MF
GO:0035255 ionotropic glutamate receptor binding Interacting selectively with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. MF
GO:0035254 glutamate receptor binding Interacting selectively with a glutamate receptor. MF
GO:0021541 ammon gyrus development The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons. BP
GO:0030159 receptor signaling complex scaffold activity Functions to provide a scaffold for the assembly of a multiprotein receptor signaling complex. MF
GO:0030158 protein xylosyltransferase activity Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. MF
GO:0030157 pancreatic juice secretion The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. BP
GO:0030156 benzodiazepine receptor binding Interacting selectively with the peripheral benzodiazepine receptor (PBR). MF
GO:0030155 regulation of cell adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. BP
GO:0030154 cell differentiation The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0030153 bacteriocin immunity A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. BP
GO:0030152 bacteriocin biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. BP
GO:0030151 molybdenum ion binding Interacting selectively with molybdenum (Mo) ions. MF
GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. BP
GO:0043003 positive regulation of Golgi to plasma membrane CFTR protein transport Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. BP
GO:0043002 negative regulation of Golgi to plasma membrane CFTR protein transport Any process that stops, prevents or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. BP
GO:0043001 Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. BP
GO:0043000 Golgi to plasma membrane CFTR protein transport The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. BP
GO:0043007 maintenance of rDNA Any process involved in sustaining the fidelity and copy number of rDNA repeats. BP
GO:0043006 calcium-dependent phospholipase A2 activation A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal. BP
GO:0043005 neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. CC
GO:0043004 cytoplasmic sequestering of CFTR protein The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane. BP
GO:0043009 embryonic development (sensu Vertebrata) The process whose specific outcome is the progression of the embryo over time, from zygote formation until birth. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043008 ATP-dependent protein binding Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP. MF
GO:0048860 glioblast cell division The process resulting in the physical partitioning and separation of a glioblast into daughter cells. BP
GO:0048334 regulation of mesodermal cell fate determination Any process that modulates the frequency, rate or extent of mesoderm cell fate determination. BP
GO:0048335 negative regulation of mesodermal cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm cell fate determination. BP
GO:0048336 positive regulation of mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination. BP
GO:0048337 positive regulation of mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification. BP
GO:0048330 positive regulation of axial mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification. BP
GO:0048331 axial mesoderm structural organization The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048332 mesoderm morphogenesis The process by which the anatomical structures of the mesoderm are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048333 mesodermal cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a mesoderm cell. BP
GO:0048338 mesoderm structural organization The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048339 paraxial mesoderm development The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. BP
GO:0042660 positive regulation of cell fate specification Any process that activates or enables a cell to adopt a specific fate. BP
GO:0042661 regulation of mesodermal cell fate specification Any process that modulates the frequency, rate or extent of mesoderm cell fate specification. BP
GO:0042662 negative regulation of mesodermal cell fate specification Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm cell fate specification. BP
GO:0042663 regulation of endodermal cell fate specification Any process that mediates the specification of a cell into an endoderm cell. BP
GO:0031208 POZ domain binding Interacting selectively with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors. MF
GO:0031209 SCAR complex A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction. CC
GO:0042666 negative regulation of ectodermal cell fate specification Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell. BP
GO:0042667 auditory receptor cell fate specification Process by which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0031204 posttranslational protein targeting to membrane, translocation The process by which a protein translocates through the ER membrane posttranslationally. BP
GO:0031205 Sec complex (sensu Eukaryota) A membrane associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0031206 Sec complex-associated translocon complex A translocon complex physically associated with a Sec complex. CC
GO:0031207 Sec62/Sec63 complex A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p. CC
GO:0031200 ferrichrome biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within a ferrichrome, a type of siderophore. BP
GO:0031201 SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. CC
GO:0031202 RNA splicing factor activity, transesterification mechanism An activity which binds RNA and functions to assist splicing of substrate RNA(s) by facilitating the formation and stabilization of a catalytic conformation in which the splice junctions of the RNA(s) to be spliced are positioned for a transesterification reaction that occurs between two sites within the RNA(s) to be spliced. MF
GO:0031203 posttranslational protein targeting to membrane, docking The process by which the signal sequence of a translated protein binds to and forms a complex with the Sec complex. BP
GO:0009058 biosynthetic process The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes. BP
GO:0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of macromolecules, large molecules including proteins, nucleic acids and carbohydrates. BP
GO:0009052 pentose-phosphate shunt, non-oxidative branch The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. BP
GO:0009053 electron donor activity Any substance that is able to transfer an electron to another chemical species. MF
GO:0009050 glycopeptide catabolic process The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide. BP
GO:0009051 pentose-phosphate shunt, oxidative branch The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). BP
GO:0009056 catabolic process The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. BP
GO:0009057 macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates. BP
GO:0009054 electron acceptor activity Any substance to which an electron may be transferred. MF
GO:0009055 electron carrier activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. MF
GO:0050564 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity Catalysis of the reaction: L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H2O = N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate. MF
GO:0050565 aerobactin synthase activity Catalysis of the reaction: 4 ATP + citrate + N6-acetyl-N6-hydroxylysine = 4 ADP + 4 phosphate + aerobactin. MF
GO:0050566 asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP. MF
GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. MF
GO:0050560 aspartate-tRNA(Asn) ligase activity Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + pyrophosphate + AMP. MF
GO:0050561 glutamate-tRNA(Gln) ligase activity Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + pyrophosphate + AMP. MF
GO:0050562 lysine-tRNA(Pyl) ligase activity Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + pyrophosphate + AMP. MF
GO:0050563 trans-feruloyl-CoA synthase activity Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown. MF
GO:0050568 protein-glutamine glutaminase activity Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3. MF
GO:0050569 glycolaldehyde dehydrogenase activity Catalysis of the reaction: glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+. MF
GO:0008909 isochorismate synthase activity Catalysis of the reaction: chorismate = isochorismate. MF
GO:0008908 isochorismatase activity Catalysis of the reaction: isochorismate + H2O = 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate. MF
GO:0008907 integrase activity Catalysis of the integration of lambdoid phage DNA during establishment, probably by forming a transient DNA-protein link. MF
GO:0008906 inosine kinase activity Catalysis of the reaction: ATP + inosine = ADP + IMP. MF
GO:0008905 mannose-phosphate guanylyltransferase activity Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. MF
GO:0008904 hygromycin B kinase activity Catalysis of the reaction: ATP + hygromycin B = ADP + 7''-O-phosphohygromycin B. MF
GO:0008903 hydroxypyruvate isomerase activity Catalysis of the reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate. MF
GO:0008902 hydroxymethylpyrimidine kinase activity Catalysis of the reaction: ATP + 4-amino-2-methyl-5-hydroxymethylpyrimidine = ADP + 4-amino-2-methyl-5-phosphomethylpyrimidine. MF
GO:0008901 ferredoxin hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. MF
GO:0008900 hydrogen:potassium-exchanging ATPase activity Catalysis of the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). MF
GO:0018995 host Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. CC
GO:0018994 polar granule A small protein-containing electron dense organelle, not surrounded by a membrane, that induces the formation of and becomes incorporated into germ cells. CC
GO:0018996 molting cycle (sensu Nematoda) The periodic shedding of part or all of a cuticle, which is then replaced by a new cuticle, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0018991 oviposition The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water. BP
GO:0018990 ecdysis (sensu Insecta) The shedding of the old cuticular fragments during the molting cycle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0018993 somatic sex determination The determination of sex and sexual phenotypes in an organism's soma. BP
GO:0018992 germ-line sex determination The determination of sex and sexual phenotype in an organism's germ line. BP
GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. CC
GO:0019029 helical viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure. CC
GO:0019026 negative sense viral genome A single stranded RNA genome with the opposite nucleotide polarity as mRNA. CC
GO:0019027 ambisense viral genome A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule. CC
GO:0019024 ssRNA viral genome A viral genome composed of single stranded RNA of either positive or negative sense. CC
GO:0019025 positive sense viral genome A single stranded RNA genome with the same nucleotide polarity as mRNA. CC
GO:0019022 RNA viral genome A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked. CC
GO:0019023 dsRNA viral genome A viral genome composed of double stranded RNA. CC
GO:0019020 multipartite viral genome A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion. CC
GO:0019021 DNA viral genome A viral genome composed of deoxyribonucleic acid. CC
GO:0032168 hyphal septin ring A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins. CC
GO:0032169 prospore septin ring A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins. CC
GO:0032164 hyphal septin cap A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. CC
GO:0032165 prospore septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation. CC
GO:0032166 chlamydospore septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation. CC
GO:0032160 septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans. CC
GO:0032161 cleavage apparatus septin structure Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis. CC
GO:0032162 mating projection septin band A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection). CC
GO:0032163 hyphal septin band A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. CC
GO:0004327 formaldehyde dehydrogenase (glutathione) activity Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+. MF
GO:0002844 negative regulation of tolerance induction to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell. BP
GO:0002845 positive regulation of tolerance induction to tumor cell Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell. BP
GO:0002846 regulation of T cell tolerance induction to tumor cell Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell. BP
GO:0002847 negative regulation of T cell tolerance induction to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell. BP
GO:0002840 regulation of T cell mediated immune response to tumor cell Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell. BP
GO:0002841 negative regulation of T cell mediated immune response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell. BP
GO:0002842 positive regulation of T cell mediated immune response to tumor cell Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell. BP
GO:0002843 regulation of tolerance induction to tumor cell Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell. BP
GO:0007506 gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. BP
GO:0007507 heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. BP
GO:0015222 serotonin transporter activity Enables the directed movement of serotonin into, out of, within or between cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. MF
GO:0015224 biopterin transporter activity Enables the directed movement of biopterin into, out of, within or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. MF
GO:0007503 fat body development The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism. BP
GO:0015226 carnitine transporter activity Enables the directed movement of carnitine into, out of, within or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. MF
GO:0005999 xylulose biosynthetic process The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose. BP
GO:0005998 xylulose catabolic process The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose. BP
GO:0005997 xylulose metabolic process The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose. BP
GO:0005996 monosaccharide metabolic process The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. BP
GO:0005995 melibiose catabolic process The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. BP
GO:0005994 melibiose metabolic process The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. BP
GO:0005993 trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. BP
GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. BP
GO:0005991 trehalose metabolic process The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. BP
GO:0005990 lactose catabolic process The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose. BP
GO:0005122 torso binding Interacting selectively with the torso (tor) protein, a receptor tyrosine kinase. MF
GO:0006718 juvenile hormone biosynthetic process The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. BP
GO:0006719 juvenile hormone catabolic process The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. BP
GO:0006714 sesquiterpenoid metabolic process The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units. BP
GO:0006715 farnesol biosynthetic process The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol. BP
GO:0006716 juvenile hormone metabolic process The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. BP
GO:0006710 androgen catabolic process The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. BP
GO:0006711 estrogen catabolic process The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. BP
GO:0006712 mineralocorticoid catabolic process The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. BP
GO:0006713 glucocorticoid catabolic process The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. BP
GO:0005123 death receptor binding Interacting selectively with a death receptor. MF
GO:0015924 mannosyl-oligosaccharide mannosidase activity Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. MF
GO:0015928 fucosidase activity Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. MF
GO:0007418 ventral midline development The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate. BP
GO:0007419 ventral cord development The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms. BP
GO:0000006 high affinity zinc uptake transporter activity Catalysis of the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. MF
GO:0000007 low-affinity zinc ion transporter activity NA MF
GO:0000002 mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome. BP
GO:0000003 reproduction The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism. BP
GO:0000001 mitochondrion inheritance The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. BP
GO:0000009 alpha-1,6-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage. MF
GO:0004716 receptor signaling protein tyrosine kinase activity NA MF
GO:0004714 transmembrane receptor protein tyrosine kinase activity NA MF
GO:0004715 non-membrane spanning protein tyrosine kinase activity NA MF
GO:0004712 protein threonine/tyrosine kinase activity NA MF
GO:0004713 protein-tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. MF
GO:0004710 MAP/ERK kinase kinase activity NA MF
GO:0004711 ribosomal protein S6 kinase activity Catalysis of the phosphorylation of ribosomal protein S6. MF
GO:0004718 Janus kinase activity NA MF
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. MF
GO:0018036 C-terminal peptidyl-asparagine amidation The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein. BP
GO:0018037 C-terminal peptidyl-aspartic acid amidation The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein. BP
GO:0018034 C-terminal peptidyl-alanine amidation The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein. BP
GO:0018035 C-terminal peptidyl-arginine amidation The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein. BP
GO:0018032 protein amino acid amidation Addition of an amide group from a glycine to a protein amino acid. BP
GO:0018033 protein C-terminal amidation The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein. BP
GO:0018030 peptidyl-lysine N6-myristoyltransferase activity NA MF
GO:0018031 peptidyl-lysine N6-palmitoyltransferase activity NA MF
GO:0018038 C-terminal peptidyl-cysteine amidation The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein. BP
GO:0018039 C-terminal peptidyl-glutamine amidation The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein. BP
GO:0051343 positive regulation of cyclic nucleotide phosphodiesterase activity Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. BP
GO:0051342 regulation of cyclic nucleotide phosphodiesterase activity Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. BP
GO:0051341 regulation of oxidoreductase activity Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. BP
GO:0051340 regulation of ligase activity Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. BP
GO:0051347 positive regulation of transferase activity Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. BP
GO:0051346 negative regulation of hydrolase activity Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. BP
GO:0051345 positive regulation of hydrolase activity Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. BP
GO:0051344 negative regulation of cyclic nucleotide phosphodiesterase activity Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate. BP
GO:0051349 positive regulation of lyase activity Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. BP
GO:0051348 negative regulation of transferase activity Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. BP
GO:0015251 ammonium channel activity NA MF
GO:0015250 water channel activity NA MF
GO:0015252 hydrogen ion channel activity NA MF
GO:0015255 propanediol channel activity NA MF
GO:0015254 glycerol channel activity NA MF
GO:0015257 organic anion channel activity NA MF
GO:0015256 monocarboxylate channel activity NA MF
GO:0015259 glutamate channel activity NA MF
GO:0015258 gluconate channel activity NA MF
GO:0016786 selenotransferase activity NA MF
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. MF
GO:0016784 3-mercaptopyruvate sulfurtransferase activity Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. MF
GO:0016785 transferase activity, transferring selenium-containing groups Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor). MF
GO:0016782 transferase activity, transferring sulfur-containing groups Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). MF
GO:0016783 sulfurtransferase activity Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). MF
GO:0016780 phosphotransferase activity, for other substituted phosphate groups Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). MF
GO:0016781 phosphotransferase activity, paired acceptors Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors. MF
GO:0016788 hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond. MF
GO:0016789 carboxylic ester hydrolase activity Catalysis of the reaction: carboxylic ester + H2O = an alcohol + a carboxylate. MF
GO:0015789 UDP-N-acetylgalactosamine transport The directed movement of UDP-N-acetylgalactosamine into, out of, within or between cells. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0015788 UDP-N-acetylglucosamine transport The directed movement of UDP-N-acetylglucosamine into, out of, within or between cells. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0015783 GDP-fucose transport The directed movement of GDP-fucose into, out of, within or between cells. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. BP
GO:0015782 CMP-sialic acid transport The directed movement of CMP-sialic acid into, out of, within or between cells. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate. BP
GO:0015781 pyrimidine nucleotide-sugar transport The directed movement of pyrimidine nucleotide-sugars into, out of, within or between cells. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. BP
GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. BP
GO:0015787 UDP-glucuronic acid transport The directed movement of UDP-glucuronic acid into, out of, within or between cells. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. BP
GO:0015786 UDP-glucose transport The directed movement of UDP-glucose into, out of, within or between cells. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate. BP
GO:0015785 UDP-galactose transport The directed movement of UDP-galactose into, out of, within or between cells. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. BP
GO:0015784 GDP-mannose transport The directed movement of GDP-mannose into, out of, within or between cells. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate. BP
GO:0001878 response to yeast A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. BP
GO:0001879 detection of yeast The series of events in which a stimulus from a yeast is received and converted into a molecular signal. BP
GO:0001874 zymosan receptor activity Combining with zymosan to initiate a change in cell activity. MF
GO:0001875 lipopolysaccharide receptor activity Combining with lipopolysaccharide to initiate a change in cell activity. MF
GO:0001876 lipoarabinomannan binding Interacting selectively with lipoarabinomannan. MF
GO:0001877 lipoarabinomannan receptor activity Combining with lipoarabinomannan to initiate a change in cell activity. MF
GO:0001870 positive regulation of complement activation, lectin pathway Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway. BP
GO:0001871 pattern binding Interacting selectively with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan. MF
GO:0001872 zymosan binding Interacting selectively with zymosan. MF
GO:0001873 polysaccharide receptor activity Combining with a polysaccharide to initiate a change in cell activity. MF
GO:0030319 di-, tri-valent inorganic anion homeostasis The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic anions within a cell or between a cell and its external environment. BP
GO:0030318 melanocyte differentiation The process whereby a relatively unspecialized cell acquires specialized features of a melanocyte. BP
GO:0007414 axonal defasciculation Separation of axons away from a bundle of axons known as a fascicle. BP
GO:0030315 T-tubule Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. CC
GO:0030314 junctional membrane complex Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules). CC
GO:0030317 sperm motility Any process involved in the controlled movement of a sperm cell. BP
GO:0030316 osteoclast differentiation The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. BP
GO:0030311 poly-N-acetyllactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. BP
GO:0030310 poly-N-acetyllactosamine catabolic process The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. BP
GO:0030313 cell envelope Everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present. CC
GO:0030312 external encapsulating structure A structure that lies outside the plasma membrane and surrounds the entire cell. CC
GO:0002080 acrosomal membrane The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. CC
GO:0007415 defasciculation of motor neuron axon Separation of a motor axon away from a bundle of axons known as a fascicle. BP
GO:0035120 post-embryonic appendage morphogenesis The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch. BP
GO:0035123 embryonic dorsal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. BP
GO:0016258 N-glycan diversification The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases. BP
GO:0016259 selenocysteine metabolic process The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins. BP
GO:0035122 embryonic medial fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. BP
GO:0016250 N-sulfoglucosamine sulfohydrolase activity Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + SO4(2-) (sulfate). MF
GO:0016251 general RNA polymerase II transcription factor activity Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF). MF
GO:0016252 nonspecific RNA polymerase II transcription factor activity Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set. MF
GO:0016253 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + peptide = UDP + N-acetyl-beta-D-glucosaminyl-peptide. MF
GO:0016254 preassembly of GPI anchor in ER membrane The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. BP
GO:0016255 attachment of GPI anchor to protein A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. BP
GO:0016256 N-glycan processing to lysosome The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome. BP
GO:0016257 N-glycan processing to secreted and cell-surface N-glycans The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus. BP
GO:0017129 triglyceride binding Interacting selectively with any triester of glycerol. MF
GO:0017128 phospholipid scramblase activity NA MF
GO:0002086 diaphragm contraction A process leading to shortening and/or development of tension in the diaphragm. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange. BP
GO:0017121 phospholipid scrambling The process by which all major lipid classes are redistributed within the plasma membrane following cell activation or injury, resulting in surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). Cell surface-exposed PS can serve as receptor sites for coagulation enzyme complexes, and contributes to cell clearance by the reticuloendothelial system. BP
GO:0017120 polyphosphoinositide phosphatase activity Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization. MF
GO:0017123 Ral GTPase activator activity Increases the rate of GTP hydrolysis by a GTPase of the Ral family. MF
GO:0017122 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase complex Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide. CC
GO:0017125 deoxycytidyl transferase activity Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA. MF
GO:0017124 SH3 domain binding Interacting selectively with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. MF
GO:0017127 cholesterol transporter activity Enables the directed movement of cholesterol into, out of, within or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. MF
GO:0017126 nucleologenesis Processes involved with the formation and assembly of the nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. BP
GO:0035129 post-embryonic hindlimb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0035128 post-embryonic forelimb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. The forelimbs are the front limbs of an organism. BP
GO:0045089 positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. BP
GO:0045088 regulation of innate immune response Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. BP
GO:0045085 negative regulation of interleukin-2 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. BP
GO:0045084 positive regulation of interleukin-12 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12. BP
GO:0045087 innate immune response The innate immune response is the first line of defense against infection. It can also activate the adaptive immune response via inflammation as a danger signal that something has damaged the host tissue. BP
GO:0045086 positive regulation of interleukin-2 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. BP
GO:0045081 negative regulation of interleukin-10 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10. BP
GO:0045080 positive regulation of chemokine biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. BP
GO:0045083 negative regulation of interleukin-12 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12. BP
GO:0045082 positive regulation of interleukin-10 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10. BP
GO:0047810 D-alanine transaminase activity Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate. MF
GO:0047811 D-alanine gamma-glutamyltransferase activity Catalysis of the reaction: L-glutamine + D-alanine = NH3 + g-L-glutamyl-D-alanine. MF
GO:0047812 D-amino-acid N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid. MF
GO:0047813 D-arabinitol 4-dehydrogenase activity Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH. MF
GO:0031046 spindle pole body duplication in cytoplasm Construction of a new spindle pole body adjacent to the existing spindle pole body exterior to the outer nuclear envelope. BP
GO:0047815 D-arabinonolactonase activity Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate. MF
GO:0031044 O-glycan processing, core 8 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-1->3-GalNAc. BP
GO:0047817 D-arginase activity Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea. MF
GO:0047818 D-fuconate dehydratase activity Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O. MF
GO:0047819 D-glutamate(D-aspartate) oxidase activity Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2. MF
GO:0031048 small RNA-mediated chromatin silencing Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region. BP
GO:0031049 programmed DNA elimination Removal of micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES), from the developing macronucleus (anlage) of a ciliate. BP
GO:0031594 neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction. CC
GO:0009299 mRNA transcription The synthesis of messenger RNA (mRNA) from a DNA template. BP
GO:0031596 ER proteasome complex A proteasome found in the endoplasmic reticulum of a cell. CC
GO:0031597 cytosolic proteasome complex (sensu Eukaryota) A proteasome found in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0031590 wybutosine metabolic process The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. BP
GO:0031591 wybutosine biosynthetic process The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. BP
GO:0031592 centrosomal corona An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin. CC
GO:0031593 polyubiquitin binding Interacting selectively and non-covalently with a polymer of ubiqutin. MF
GO:0009290 DNA import into cell during transformation The directed movement of DNA into a cell during the process of transformation, the uptake of foreign genetic material into a cell. BP
GO:0009291 unidirectional conjugation The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. BP
GO:0009292 genetic transfer In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual. BP
GO:0009293 transduction The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector. BP
GO:0009294 DNA mediated transformation The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material. BP
GO:0031599 ER proteasome regulatory particle The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell. CC
GO:0009296 flagellum biogenesis The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. BP
GO:0009297 pilus biogenesis The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation and plays a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. BP
GO:0030268 methylenetetrahydromethanopterin dehydrogenase activity Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420. MF
GO:0021689 cerebellar molecular layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. BP
GO:0021688 cerebellar molecular layer formation The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. BP
GO:0032762 mast cell cytokine production Any process that contributes to cytokine production by a mast cell. BP
GO:0032763 regulation of mast cytokine production Any process that modulates the frequency, rate, or extent of mast cell cytokine production. BP
GO:0032760 positive regulation of tumor necrosis factor-alpha production Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor-alpha production. BP
GO:0032761 positive regulation of tumor necrosis factor-beta production Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor-beta production. BP
GO:0032766 NHE3/E3KARP/ACTN4 complex A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments. CC
GO:0032767 copper-dependent protein binding Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper. MF
GO:0032764 negative regulation of mast cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production. BP
GO:0032765 positive regulation of mast cytokine production Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production. BP
GO:0032768 regulation of monooxygenase activity Any process that modulates the activity of a monooxygenase. BP
GO:0032769 negative regulation of monooxygenase activity Any process that stops or reduces the activity of a monooxygenase. BP
GO:0021685 cerebellar granular layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. BP
GO:0021684 cerebellar granular layer formation The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. BP
GO:0008653 lipopolysaccharide metabolic process The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. BP
GO:0008652 amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. BP
GO:0043661 peribacteroid membrane A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). CC
GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 2'-O atom of a uridine residue in an rRNA molecule. MF
GO:0008657 DNA gyrase inhibitor activity Stops, prevents or reduces the activity of DNA gyrase. MF
GO:0008656 caspase activator activity Increases the rate of proteolysis catalyzed by a caspase. MF
GO:0008655 pyrimidine salvage Any process that generates a pyrimidine, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. BP
GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. BP
GO:0008659 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O. MF
GO:0008658 penicillin binding Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system. MF
GO:0045508 interleukin-26 receptor activity Combining with interleukin-26 to initiate a change in cell activity. MF
GO:0045509 interleukin-27 receptor activity Combining with interleukin-27 to initiate a change in cell activity. MF
GO:0045500 sevenless signaling pathway The series of molecular signals generated as a consequence of the sevenless receptor binding to one of its physiological ligands. BP
GO:0045501 regulation of sevenless signaling pathway Any process that modulates the frequency, rate or extent of the sevenless signaling pathway. BP
GO:0045502 dynein binding Interacting selectively with dynein, the multisubunit protein complex that is associated with microtubules. MF
GO:0045503 dynein light chain binding Interacting selectively with a light chain of the dynein complex. MF
GO:0045504 dynein heavy chain binding Interacting selectively with a heavy chain of the dynein complex. MF
GO:0004758 serine C-palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2. MF
GO:0045506 interleukin-24 receptor activity Combining with interleukin-24 to initiate a change in cell activity. MF
GO:0045507 interleukin-25 receptor activity Combining with interleukin-25 to initiate a change in cell activity. MF
GO:0042040 metal incorporation into metallo-molybdopterin complex The incorporation of a metal into a metallo-molybdopterin complex. BP
GO:0042042 tungsten incorporation into tungsten-molybdopterin complex The incorporation of tungsten into a tungsten-molybdopterin complex. BP
GO:0042043 neurexin binding Interacting selectively with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. MF
GO:0042044 fluid transport The directed movement of substances that are in liquid form in normal living conditions into, out of, within or between cells. BP
GO:0042045 epithelial fluid transport The directed movement of fluid across epithelia. BP
GO:0042046 W-molybdopterin cofactor metabolic process The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. BP
GO:0042047 W-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. BP
GO:0042048 olfactory behavior The actions or reactions of an organism in response to an odor. BP
GO:0042049 cell acyl-CoA homeostasis Any of the processes involved in the maintenance of an internal equilibrium of acyl-CoA within a cell or between a cell and its external environment. BP
GO:0042156 zinc-mediated transcriptional activator activity Initiates or upregulates transcription in the presence of zinc. MF
GO:0047389 glycerophosphocholine phosphodiesterase activity Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. MF
GO:0018078 peptidyl-thyronine iodination The posttranslational iodination of peptidyl-thyronine, formed from tyrosine. BP
GO:0015296 anion:cation symporter activity Catalysis of the reaction: anion(out) + cation(out) = anion(in) + cation(in). MF
GO:0047386 fructose-2,6-bisphosphate 6-phosphatase activity Catalysis of the reaction: H2O + D-fructose 2,6-bisphosphate = phosphate + fructose-2-phosphate. MF
GO:0047387 serine-ethanolaminephosphate phosphodiesterase activity Catalysis of the reaction: H2O + serine phosphoethanolamine = phosphoryl-ethanolamine + L-serine. MF
GO:0050698 proteoglycan sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans. MF
GO:0050699 WW domain binding Interacting selectively with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. MF
GO:0050696 trichloroethylene catabolic process The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent. BP
GO:0050697 1,1,2-trichloroethene reductive dehalogenase activity Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene. MF
GO:0050694 galactose 3-O-sulfotransferase activity Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc. MF
GO:0050695 benzoylformate decarboxylase activity Catalysis of the reaction: benzoylformate = benzaldehyde + CO2. MF
GO:0050692 DBD domain binding Interacting selectively with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors. MF
GO:0050693 LBD domain binding Interacting selectively with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. MF
GO:0050690 regulation of antiviral response by virus Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. BP
GO:0015298 solute:cation antiporter activity Catalysis of the reaction: solute(out) + cation(in) = solute(in) + cation(out). MF
GO:0046743 viral capsid transport in host cell cytoplasm The directed movement of viral capsid proteins within the cytoplasm of the host cell. BP
GO:0046742 viral capsid transport in host cell nucleus The directed movement of viral capsid proteins within the nucleus of the host cell. BP
GO:0046741 spread of virus within host, tissue to tissue The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host tissue. BP
GO:0046740 spread of virus within host, cell to cell The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host cells. BP
GO:0046747 virus budding from Golgi membrane during viral capsid re-envelopment The re-envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring an additional membrane envelope. BP
GO:0046746 virus budding from nuclear membrane during viral capsid re-envelopment The re-envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring an additional membrane envelope. BP
GO:0046745 viral capsid re-envelopment The process by which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope. BP
GO:0046744 viral capsid envelopment The process by which a capsid acquires a membrane envelope. BP
GO:0046749 virus budding from nuclear membrane during viral capsid envelopment The envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring a membrane envelope. BP
GO:0046748 virus budding from ER membrane during viral capsid re-envelopment The re-envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring an additional membrane envelope. BP
GO:0002651 positive regulation of tolerance induction to self antigen Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen. BP
GO:0002650 negative regulation of tolerance induction to self antigen Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen. BP
GO:0002653 negative regulation of tolerance induction dependent upon immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response. BP
GO:0005604 basement membrane A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. CC
GO:0002655 regulation of tolerance induction to nonself antigen Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen. BP
GO:0002654 positive regulation of tolerance induction dependent upon immune response Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response. BP
GO:0002657 positive regulation of tolerance induction to nonself antigen Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen. BP
GO:0005600 collagen type XIII A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes. CC
GO:0002659 negative regulation of peripheral tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction. BP
GO:0002658 regulation of peripheral tolerance induction Any process that modulates the frequency, rate, or extent of peripheral tolerance induction. BP
GO:0005609 laminin-4 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta2 and gamma1. CC
GO:0005608 laminin-3 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha1, beta2 and gamma1. CC
GO:0002389 tolerance induction in Peyer's patch Tolerance induction taking place in the Peyer's patches. BP
GO:0002388 immune response in Peyer's patch Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine. BP
GO:0002383 immune response in brain or nervous system An immune response taking place in the brain or nervous system. BP
GO:0002382 regulation of tissue kallikrein-kinin cascade Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade. BP
GO:0030050 vesicle transport along actin filament Movement of a vesicle along an actin filament, mediated by motor proteins. BP
GO:0002380 immunoglobulin secretion during immune response The regulated release of immunoglobulins from a B cell or plasma cell during an immune response. BP
GO:0030056 hemidesmosome Point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments. CC
GO:0030057 desmosome Button-like point of intercellular contact through which the intermediate filaments of adjacent cells are connected indirectly. CC
GO:0030054 cell junction A specialized region of connection between two cells or between a cell and the extracellular matrix. CC
GO:0030055 cell-matrix junction A specialized region of connection between a cell and the extracellular matrix. CC
GO:0031909 peroxisomal lumen The volume enclosed by the membranes of a peroxisome. CC
GO:0031908 glyoxysomal lumen The volume enclosed by the membranes of a glyoxysome. CC
GO:0031907 microbody lumen The volume enclosed by the membranes of a microbody. CC
GO:0031906 late endosome lumen The volume enclosed by the membranes of a late endosome. CC
GO:0031905 early endosome lumen The volume enclosed by the membranes of an early endosome. CC
GO:0031904 endosome lumen The volume enclosed by the membranes of an endosome. CC
GO:0031903 microbody membrane The lipid bilayer surrounding a microbody. CC
GO:0031902 late endosome membrane The lipid bilayer surrounding a late endosome. CC
GO:0031901 early endosome membrane The lipid bilayer surrounding an early endosome. CC
GO:0031900 chromoplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope. CC
GO:0004555 alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. MF
GO:0004556 alpha-amylase activity Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. MF
GO:0004557 alpha-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase. MF
GO:0004550 nucleoside diphosphate kinase activity Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. MF
GO:0004551 nucleotide diphosphatase activity Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. MF
GO:0004552 octanol dehydrogenase activity Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + NADH + H+. MF
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds NA MF
GO:0004558 alpha-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose. MF
GO:0004559 alpha-mannosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. MF
GO:0048165 fused antrum stage, oogenesis (sensu Mammalia) The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048164 distinct antral spaces stage, oogenesis (sensu Mammalia) The stage in oogenesis when the antral spaces become distinct and the first polar body forms. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048167 regulation of synaptic plasticity A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. BP
GO:0048166 mature follicle stage, oogenesis (sensu Mammalia) The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048161 double layer follicle stage, oogenesis (sensu Mammalia) The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048160 primary follicle stage, oogenesis (sensu Mammalia) The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048163 scattered antral spaces stage, oogenesis (sensu Mammalia) The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048162 multi-layer follicle stage, oogenesis (sensu Mammalia) The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048169 regulation of long-term neuronal synaptic plasticity A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. BP
GO:0048168 regulation of neuronal synaptic plasticity A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. BP
GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. MF
GO:0042445 hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. BP
GO:0042446 hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. BP
GO:0042447 hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. BP
GO:0042440 pigment metabolic process The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. BP
GO:0042441 eye pigment metabolic process The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. BP
GO:0042442 melatonin catabolic process The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine). BP
GO:0042443 phenylethylamine metabolic process The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. BP
GO:0050335 thiocyanate isomerase activity Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate. MF
GO:0050334 thiaminase activity Catalysis of the reaction: thiamin + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole. MF
GO:0050337 thiosulfate-thiol sulfurtransferase activity Catalysis of the reaction: thiosulfate + 2 glutathione = SO3(2-) (sulfite) + glutathione disulfide + sulfide. MF
GO:0050336 thioethanolamine S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine. MF
GO:0050331 thiamin diphosphate kinase activity Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate. MF
GO:0050330 theanine hydrolase activity Catalysis of the reaction: N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine. MF
GO:0018548 pentaerythritol tetranitrate reductase activity Catalysis of the reaction: pentaerythritol tri(or tetra)nitrate + NADPH = NADP+ + NO3- (nitrate) + pentaerythritol di(or tri)nitrate. MF
GO:0050332 thiamin pyridinylase activity Catalysis of the reaction: thiamin + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole. MF
GO:0018546 nitrobenzene nitroreductase activity NA MF
GO:0008087 light-activated voltage-gated calcium channel complex NA CC
GO:0018544 4-carboxy-4'-sulfoazobenzene reductase activity Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate. MF
GO:0018545 NAD(P)H nitroreductase activity NA MF
GO:0050339 thymidine-triphosphatase activity Catalysis of the reaction: dTTP + H2O = dTDP + phosphate. MF
GO:0050338 thiosulfate dehydrogenase activity Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c. MF
GO:0018540 hydroxybenzoquinone reductase activity Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + NADH + H+ = NAD+ + 1,2,4-benzenetriol. MF
GO:0018541 p-benzoquinone reductase (NADPH) activity Catalysis of the reaction: NADPH + H+ + p-benzoquinone = NADP+ + hydroquinone. MF
GO:0007146 meiotic recombination nodule assembly The assembly of small, electron dense structures in association with meiotic chromosomes. BP
GO:0007147 female meiosis II The cell cycle process whereby the second meiotic division occurs in the female germline. BP
GO:0007144 female meiosis I The cell cycle process whereby the first meiotic division occurs in the female germline. BP
GO:0007142 male meiosis II Progression through male meiosis II, the second meiotic division in the male germline. BP
GO:0007143 female meiosis Meiosis in the female germline. BP
GO:0007140 male meiosis Meiosis in the male germline. BP
GO:0007141 male meiosis I Progression through male meiosis I, the first meiotic division in the male germline. BP
GO:0032377 regulation of intracellular lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. BP
GO:0052209 interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction. BP
GO:0052208 modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction. BP
GO:0052203 modification of enzyme activity in other organism during symbiotic interaction The process by which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052202 negative regulation by symbiont of defense-related host cell wall callose deposition Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052201 response to symbiont defenses A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052200 response to host defenses A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052207 modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction. BP
GO:0052206 modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction. BP
GO:0052205 modification of protein function in other organism during symbiotic interaction The process by which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052204 negative regulation of protein function in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0032370 positive regulation of lipid transport Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells. BP
GO:0032373 positive regulation of sterol transport Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells. BP
GO:0032372 negative regulation of sterol transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells. BP
GO:0017158 regulation of calcium ion-dependent exocytosis Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. BP
GO:0051698 saccharopine oxidase activity Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2. MF
GO:0017150 tRNA dihydrouridine synthase activity NA MF
GO:0017151 DEAD/H-box RNA helicase binding Interacting selectively with the enzyme DEAD/H-box RNA helicase. MF
GO:0017153 sodium:dicarboxylate symporter activity Catalysis of the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). MF
GO:0051695 actin filament uncapping The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. BP
GO:0017155 sodium:hydrogen antiporter regulator activity NA MF
GO:0017156 calcium ion-dependent exocytosis The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions. BP
GO:0017157 regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis. BP
GO:0015426 polar-amino acid-transporting ATPase activity Catalysis of the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). MF
GO:0015424 amino acid-transporting ATPase activity Catalysis of the reaction: ATP + H2O + amino acid(out) = ADP + phosphate + amino acid(in). MF
GO:0015425 nonpolar-amino acid-transporting ATPase activity Catalysis of the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). MF
GO:0015422 oligosaccharide-transporting ATPase activity Catalysis of the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in). MF
GO:0015423 maltose-transporting ATPase activity Catalysis of the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in). MF
GO:0015420 cobalamin-transporting ATPase activity Catalysis of the reaction: ATP + H2O + cobalamin(out) = ADP + phosphate + cobalamin(in). Cobalamin = vitamin B12. MF
GO:0015421 oligopeptide-transporting ATPase activity Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in). MF
GO:0015428 type I protein secretor activity NA MF
GO:0021999 neural plate anterioposterior pattern formation The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. BP
GO:0021998 neural plate mediolateral pattern formation The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate. BP
GO:0021991 neural plate thickening The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode. BP
GO:0021990 neural plate formation The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. BP
GO:0021993 initiation of neural tube closure The process by which closure points are established at multiple points and along the neural rostrocaudal axis. BP
GO:0021992 cell proliferation involved in neural plate elongation The process of rapid expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue. BP
GO:0021995 neuropore closure The process of joining together the neural folds at either end of the neural tube. BP
GO:0021994 progression of neural tube closure The process whereby the neural folds are fused extending from the initial closure points. BP
GO:0021997 neural plate pattern formation The pattern specification process whereby the axes of the nervous system are established. BP
GO:0021996 lamina terminalis formation The process whereby the anterior-most portion of the neural axis is formed by closure of the anterior neuropore. BP
GO:0016871 cycloartenol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol. MF
GO:0016215 CoA desaturase activity NA MF
GO:0016216 isopenicillin-N synthase activity Catalysis of the reaction: O2 + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine = isopenicillin-N + H2O. MF
GO:0046239 phthalate catabolic process The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid. BP
GO:0046025 precorrin-6Y C5,15-methyltransferase (decarboxylating) activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2. MF
GO:0046232 carbazole catabolic process The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. BP
GO:0046230 2-aminobenzenesulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. BP
GO:0046236 mandelate biosynthetic process The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. BP
GO:0046235 gallate biosynthetic process The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). BP
GO:0016211 ammonia ligase activity NA MF
GO:0030298 receptor signaling protein tyrosine kinase activator activity NA MF
GO:0030299 cholesterol absorption Uptake of cholesterol into the blood by absorption from the small intestine. BP
GO:0046020 negative regulation of transcription from RNA polymerase II promoter by pheromones Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. BP
GO:0030290 sphingolipid activator protein activity Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase. MF
GO:0030291 protein serine/threonine kinase inhibitor activity Stops, prevents or reduces the activity of a protein serine/threonine kinase. MF
GO:0030292 protein tyrosine kinase inhibitor activity Stops, prevents or reduces the activity of a protein tyrosine kinase. MF
GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis. BP
GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity NA MF
GO:0030295 protein kinase activator activity Increases the activity of a protein kinase, an enzyme which phosphorylates a protein. MF
GO:0030296 protein tyrosine kinase activator activity Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. MF
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity NA MF
GO:0005021 vascular endothelial growth factor receptor activity Combining with vascular endothelial growth factor to initiate a change in cell activity. MF
GO:0005020 stem cell factor receptor activity Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity. MF
GO:0005026 transforming growth factor beta receptor activity, type II Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of a type I activin receptor. MF
GO:0005025 transforming growth factor beta receptor activity, type I Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of a type I TGF-beta receptor. MF
GO:0005024 transforming growth factor beta receptor activity Combining with transforming growth factor beta to initiate a change in cell activity. MF
GO:0031653 heat dissipation Any process by which an organism releases excess heat to the environment, thereby lowering its internal temperature. BP
GO:0031652 positive regulation of heat generation Any process that activates or increases the frequency, rate, or extent of heat generation. BP
GO:0031651 negative regulation of heat generation Any process that stops, prevents, or reduces the frequency, rate, or extent of heat generation. BP
GO:0031650 regulation of heat generation Any process that modulates the frequency, rate, or extent of heat generation. BP
GO:0031657 G1/S-specific regulation of cyclin-dependent protein kinase activity Any process that modulates the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle. BP
GO:0031656 positive regulation of heat dissipation Any process that activates or increases the frequency, rate, or extent of heat dissipation. BP
GO:0031655 negative regulation of heat dissipation Any process that stops, prevents, or reduces the frequency, rate, or extent of heat dissipation. BP
GO:0031654 regulation of heat dissipation Any process that modulates the frequency, rate, or extent of heat dissipation. BP
GO:0031659 G1/S-specific positive regulation of cyclin-dependent protein kinase activity Any process that activates or increases the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle. BP
GO:0031658 G1/S-specific negative regulation of cyclin-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle. BP
GO:0008284 positive regulation of cell proliferation Any process that activates or increases the rate or extent of cell proliferation. BP
GO:0008285 negative regulation of cell proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation. BP
GO:0008286 insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. BP
GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. CC
GO:0008280 cohesin core heterodimer The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes. CC
GO:0008281 sulfonylurea receptor activity Combining with sulfonylurea to initiate a change in cell activity. MF
GO:0008282 ATP-sensitive potassium channel complex NA CC
GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population. BP
GO:0008288 boss receptor activity Combining with the protein bride of sevenless (boss) to initiate a change in cell activity. MF
GO:0008289 lipid binding Interacting selectively with a lipid. MF
GO:0048842 positive regulation of axon extension involved in axon guidance Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. BP
GO:0009486 cytochrome bo3 ubiquinol oxidase activity NA MF
GO:0022406 membrane docking The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. BP
GO:0022407 regulation of cell-cell adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. BP
GO:0022404 molting cycle process A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin. BP
GO:0022405 hair cycle process A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. BP
GO:0022402 cell cycle process A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. BP
GO:0022403 cell cycle phase A cell cycle process composed of one of the morphological steps through which a cell progresses during successive cell replication or nuclear replication events. BP
GO:0022400 regulation of rhodopsin mediated signaling NA BP
GO:0022401 adaptation of signaling pathway The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. BP
GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. BP
GO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. BP
GO:0022408 negative regulation of cell-cell adhesion Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. BP
GO:0022409 positive regulation of cell-cell adhesion Any process that activates or increases the rate or extent of cell adhesion to another cell. BP
GO:0032357 oxidized purine DNA binding Interacting selectively with oxidized purine residues in DNA. MF
GO:0009732 detection of hexose stimulus The series of events in which a stimulus from a hexose substance is received and converted into a molecular signal. BP
GO:0032355 response to estradiol stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. BP
GO:0032354 response to follicle-stimulating hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. BP
GO:0032353 negative regulation of hormone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. BP
GO:0032352 positive regulation of hormone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. BP
GO:0032351 negative regulation of hormone metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone. BP
GO:0032350 regulation of hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. BP
GO:0009739 response to gibberellic acid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellic acid stimulus. BP
GO:0009738 abscisic acid mediated signaling A series of molecular signals mediated by the detection of abscisic acid. BP
GO:0032359 provirus excision The molecular events that lead to the excision of a viral genome from the host genome. BP
GO:0032358 oxidized pyrimidine DNA binding Interacting selectively with oxidized pyrimidine residues in DNA. MF
GO:0019967 interleukin-1, Type I, activating binding NA MF
GO:0019966 interleukin-1 binding Interacting selectively with interleukin-1. MF
GO:0019965 interleukin binding Interacting selectively with an interleukin. MF
GO:0019964 interferon-gamma binding Interacting selectively with interferon-gamma. MF
GO:0019962 interferon-alpha/beta binding NA MF
GO:0019961 interferon binding Interacting selectively with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. MF
GO:0019960 C-X3-C chemokine binding Interacting selectively with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. MF
GO:0019969 interleukin-10 binding Interacting selectively with interleukin-10. MF
GO:0019968 interleukin-1, Type II, blocking binding NA MF
GO:0045719 negative regulation of glycogen biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. BP
GO:0045718 negative regulation of flagellum biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a flagellum. BP
GO:0045711 positive regulation of adult salivary gland determination Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism. BP
GO:0045710 negative regulation of larval salivary gland determination Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination in a larval organism. BP
GO:0045713 low-density lipoprotein receptor biosynthetic process The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein by cells. BP
GO:0045712 positive regulation of larval salivary gland determination Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism. BP
GO:0045715 negative regulation of low-density lipoprotein receptor biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors. BP
GO:0045714 regulation of low-density lipoprotein receptor biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors. BP
GO:0045717 negative regulation of fatty acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. BP
GO:0045716 positive regulation of low-density lipoprotein receptor biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors. BP
GO:0047623 adenosine-phosphate deaminase activity Catalysis of the reaction: 5'-AMP + H2O = 5'-IMP + NH3. MF
GO:0047622 adenosine nucleosidase activity Catalysis of the reaction: adenosine + H2O = D-ribose + adenine. MF
GO:0047621 acylpyruvate hydrolase activity Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate. MF
GO:0047620 acylglycerol kinase activity Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate. MF
GO:0047627 adenylylsulfatase activity Catalysis of the reaction: adenylylsulfate + H2O = AMP + SO4(2-) (sulfate). MF
GO:0047626 adenosylmethionine hydrolase activity Catalysis of the reaction: H2O + S-adenosyl-L-methionine = L-homoserine + methylthioadenosine. MF
GO:0047625 adenosylmethionine cyclotransferase activity Catalysis of the reaction: S-adenosyl-L-methionine = 5'-methylthioadenosine + 2-aminobutan-4-olide. MF
GO:0047624 adenosine-tetraphosphatase activity Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate. MF
GO:0047629 ADP deaminase activity Catalysis of the reaction: ADP + H2O = IDP + NH3. MF
GO:0047628 ADP-thymidine kinase activity Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate. MF
GO:0006567 threonine catabolic process The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. BP
GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. BP
GO:0006565 L-serine catabolic process The chemical reactions and pathways resulting in the breakdown of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid. BP
GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid. BP
GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid. BP
GO:0006562 proline catabolic process The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. BP
GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. BP
GO:0006560 proline metabolic process The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. BP
GO:0006569 tryptophan catabolic process The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. BP
GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. BP
GO:0005034 osmosensor activity NA MF
GO:0005035 death receptor activity NA MF
GO:0048826 cotyledon morphogenesis The process by which the anatomical structures of the cotyledon are generated and organized. Morphogenesis pertains to the creation of form. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. BP
GO:0048827 phyllome development The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants. BP
GO:0005030 neurotrophin receptor activity Combining with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth, to initiate a change in cell activity. MF
GO:0005031 tumor necrosis factor receptor activity Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. MF
GO:0002020 protease binding Interacting selectively with any protease or peptidase. MF
GO:0002021 response to dietary excess The physiological process by which dietary excess is sensed by the central nervous system and results in a reduction in food intake and increased energy expenditure. BP
GO:0048828 embryonic morphogenesis (sensu Magnoliophyta) The process by which the anatomical structures of the embryo are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0048829 root cap development The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant. BP
GO:0002028 regulation of sodium ion transport Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells. BP
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway. BP
GO:0001647 G-protein coupled cytokinin receptor activity Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled. MF
GO:0001646 cAMP receptor activity Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) to initiate a change in cell activity. MF
GO:0001642 group III metabotropic glutamate receptor activity A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. MF
GO:0001641 group II metabotropic glutamate receptor activity A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. MF
GO:0001640 adenylate cyclase inhibiting metabotropic glutamate receptor activity A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity. MF
GO:0001649 osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone. BP
GO:0001648 proteinase activated receptor activity NA MF
GO:0052469 modulation by organism of salicylic acid levels in other organism during symbiotic interaction The alteration by an organism of the levels of salicylic acid in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052462 modulation by host of symbiont phagocytosis Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052460 modulation by host of nutrient release from symbiont Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0003869 4-nitrophenylphosphatase activity Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate. MF
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. MF
GO:0003861 3-isopropylmalate dehydratase activity Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O. MF
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. MF
GO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. MF
GO:0003862 3-isopropylmalate dehydrogenase activity Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. MF
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. MF
GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. MF
GO:0003867 4-aminobutyrate transaminase activity Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. MF
GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. MF
GO:0019518 threonine catabolic process to pyruvate The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound pyruvate. BP
GO:0019519 pentitol metabolic process The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule. BP
GO:0019516 lactate oxidation NA BP
GO:0019517 threonine catabolic process to D-lactate The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound D-lactate. BP
GO:0019515 lactose catabolic process via UDP-galactose The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose. BP
GO:0019512 lactose catabolic process via tagatose-6-phosphate The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate. BP
GO:0019513 lactose catabolic process, using glucoside 3-dehydrogenase The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13). BP
GO:0019510 S-adenosylhomocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine. BP
GO:0019511 peptidyl-proline hydroxylation NA BP
GO:0042978 ornithine decarboxylase activator activity Upregulation of the activity of the enzyme ornithine decarboxylase. MF
GO:0042979 ornithine decarboxylase regulator activity Modulation of the activity of the enzyme ornithine decarboxylase. MF
GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). MF
GO:0004078 biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)). MF
GO:0042974 retinoic acid receptor binding Interacting selectively with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. MF
GO:0042975 peroxisome proliferator activated receptor binding Interacting selectively with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. MF
GO:0042976 activation of JAK protein The process of introducing a phosphoric group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. BP
GO:0042977 tyrosine phosphorylation of JAK2 protein The process of introducing a phosphoric group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it. BP
GO:0042970 homoserine transporter activity Enables the directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of, within or between cells. MF
GO:0042971 lactone transporter activity Enables the directed movement of lactone, any of a series of organic compounds, regarded as anhydrides of certain hydroxy acids, into, out of, within or between cells. MF
GO:0004071 aspartate-ammonia ligase activity Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine. MF
GO:0042973 glucan endo-1,3-beta-D-glucosidase activity Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans. MF
GO:0015344 siderophore-iron (ferrioxamine) uptake transporter activity Catalysis of the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). MF
GO:0050108 monoterpenyl-diphosphatase activity Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate. MF
GO:0050109 morphine 6-dehydrogenase activity Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+. MF
GO:0050102 cellodextrin phosphorylase activity Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. MF
GO:0050103 dextrin dextranase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1). MF
GO:0050100 methylitaconate delta-isomerase activity Catalysis of the reaction: methylitaconate = dimethylmaleate. MF
GO:0050101 mimosinase activity Catalysis of the reaction: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine. MF
GO:0050106 monomethyl-sulfatase activity Catalysis of the reaction: monomethyl sulfate + H2O = methanol + SO4(2-) (sulfate). MF
GO:0050107 monoterpenol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester. MF
GO:0050104 L-gulonate 3-dehydrogenase activity Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH. MF
GO:0006827 high affinity iron ion transport NA BP
GO:0048686 regulation of sprouting of injured axon Any process that modulates the frequency, rate or extent of sprouting of an injured axon. BP
GO:0003856 3-dehydroquinate synthase activity Catalysis of the reaction: 3-deoxy-arabino-heptulosonate 7-phosphate = 3-dehydroquinate + phosphate. MF
GO:0051471 ectoine transporter activity Enables the directed movement of ectoine into, out of, within or between cells. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria. MF
GO:0051470 ectoine transport The directed movement of ectoine into, out of, within or between cells. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria. BP
GO:0051473 glucosylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. BP
GO:0051472 glucosylglycerol metabolic process The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. BP
GO:0051475 glucosylglycerol transport The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of, within or between cells. BP
GO:0005853 eukaryotic translation elongation factor 1 complex A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. CC
GO:0005850 eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. CC
GO:0051476 mannosylglycerate transport The directed movement of mannosylglycerate into, out of, within or between cells. BP
GO:0051479 mannosylglycerate biosynthetic process The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. BP
GO:0051478 mannosylglycerate metabolic process The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. BP
GO:0005858 axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which in converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains. CC
GO:0005859 muscle myosin complex A filament of myosin found in a muscle cell of any type. CC
GO:0017062 cytochrome bc(1) complex assembly Formation of cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation and bonding together of its constituents. BP
GO:0048680 positive regulation of axon regeneration Any process that activates, maintains or increases the rate of axon regeneration. BP
GO:0048681 negative regulation of axon regeneration Any process that stops, prevents or reduces the frequency, rate or extent of axon regeneration. BP
GO:0004082 bisphosphoglycerate mutase activity Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. MF
GO:0048683 regulation of collateral sprouting of intact axon in response to injury Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon. BP
GO:0004083 bisphosphoglycerate phosphatase activity Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 3-phosphoglycerate + phosphate. MF
GO:0004080 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)). MF
GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. MF
GO:0042967 acyl-carrier-protein biosynthetic process The chemical reactions and pathways resulting in the formation of acyl-carrier protein. BP
GO:0004087 carbamoyl-phosphate synthase (ammonia) activity Catalysis of the reaction: 2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate. MF
GO:0031086 mRNA catabolic process, deadenylation-independent decay A pathway of mRNA degradation that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability. BP
GO:0004084 branched-chain-amino-acid transaminase activity Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. MF
GO:0031087 deadenylation-independent decapping Cleavage of the 5'-cap of an mRNA that is independent of poly(A) tail shortening. BP
GO:0004085 butyryl-CoA dehydrogenase activity Catalysis of the reaction: butanoyl-CoA + ETF = 2-butenoyl-CoA + reduced ETF. MF
GO:0047856 dihydrocoumarin hydrolase activity Catalysis of the reaction: dihydrocoumarin + H2O = melilotate. MF
GO:0031085 BLOC-3 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins. CC
GO:0031082 BLOC complex Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. CC
GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. MF
GO:0047851 dicarboxylate-CoA ligase activity Catalysis of the reaction: ATP + an omega-dicarboxylic acid = AMP + diphosphate + an omega-carboxyacyl-CoA. MF
GO:0004089 carbonate dehydratase activity Catalysis of the reaction: H2CO3 = CO2 + H2O. MF
GO:0031080 Nup107-160 complex A subcomplex of the nuclear pore complex (NPC) mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p. CC
GO:0047853 difructose-anhydride synthase activity Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose. MF
GO:0006008 glucose 1-phosphate utilization NA BP
GO:0006009 glucose 1-phosphate phosphorylation The process of introducing a phosphoric group into glucose 1-phosphate to produce glucose bisphosphate. BP
GO:0006004 fucose metabolic process The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. BP
GO:0006005 L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose). BP
GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. BP
GO:0006007 glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. BP
GO:0006000 fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. BP
GO:0006001 fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose. BP
GO:0006002 fructose 6-phosphate metabolic process The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. BP
GO:0006003 fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. BP
GO:0047859 dihydroxyphenylalanine ammonia-lyase activity Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3. MF
GO:0014050 negative regulation of glutamate secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of glutamate. BP
GO:0014051 gamma-aminobutyric acid secretion The regulated release of gamm-aminobutyric acid by a cell or group of cells. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues. BP
GO:0014052 regulation of gamma-aminobutyric acid secretion Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. BP
GO:0014053 negative regulation of gamma-aminobutyric acid secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. BP
GO:0014054 positive regulation of gamma-aminobutyric acid secretion Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. BP
GO:0014055 acetylcholine secretion The regulated release of acetylcholine by a cell or group of cells. The acetylcholine is a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS). BP
GO:0014056 regulation of acetylcholine secretion Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. BP
GO:0014057 positive regulation of acetylcholine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine. BP
GO:0014058 negative regulation of acetylcholine secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of acetylcholine. BP
GO:0014059 regulation of dopamine secretion Any process that modulates the frequency, rate or extent of the regulated release of dopamine. BP
GO:0015099 nickel ion transporter activity Enables the directed movement of nickel (Ni) ions into, out of, within or between cells. MF
GO:0015098 molybdate ion transporter activity Enables the directed movement of molybdate (MoO4 2-) ions into, out of, within or between cells. Molybdate is the bivalent anion derived from molybdic acid. MF
GO:0015093 ferrous iron transporter activity Enables the directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells. MF
GO:0015092 high affinity ferric uptake transporter activity Catalysis of the import of Fe(III). MF
GO:0015091 ferric iron transporter activity Enables the directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of, within or between cells. MF
GO:0015090 low affinity iron ion transporter activity Catalysis of the reaction: Fe2+(out) = Fe2+(in). MF
GO:0015097 mercury ion transporter activity Enables the directed movement of mercury (Hg) ions into, out of, within or between cells. MF
GO:0015096 manganese resistance permease activity NA MF
GO:0015095 magnesium ion transporter activity Enables the directed movement of magnesium (Mg) ions into, out of, within or between cells. MF
GO:0015094 lead ion transporter activity Enables the directed movement of lead (Pb) ions into, out of, within or between cells. MF
GO:0047421 N-acyl-D-glutamate deacylase activity Catalysis of the reaction: H2O + N-acyl-D-glutamate = D-glutamate + carboxylate. MF
GO:0047420 N-acyl-D-amino-acid deacylase activity Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid. MF
GO:0047423 N-methylhydantoinase (ATP-hydrolyzing) activity Catalysis of the reaction: 2 H2O + N-methylhydantoin + ATP = phosphate + N-carbamoylsarcosine + ADP. MF
GO:0047422 N-acyl-D-aspartate deacylase activity Catalysis of the reaction: H2O + N-acyl-D-aspartate = D-aspartate + carboxylate. MF
GO:0047425 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity Catalysis of the reaction: H2O + 1-pyrroline-4-hydroxy-2-carboxylate = NH3 + 2,5-dioxopentanoate. MF
GO:0047424 methylenediurea deaminase activity Catalysis of the reaction: 2 H2O + NH(2)-CO-NH-CH(2)-NH-CO-NH(2) = CO2 + 2 NH3 + N-hydroxymethylurea. MF
GO:0047427 cyanoalanine nitrilase activity Catalysis of the reaction: 2 H2O + 3-cyano-L-alanine = NH3 + L-aspartate. MF
GO:0047426 ricinine nitrilase activity Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone. MF
GO:0047429 nucleoside-triphosphate diphosphatase activity Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. MF
GO:0047428 arylacetonitrilase activity Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3. MF
GO:0002027 cardiac chronotropy Any process that modulates the frequency or rate of heart contraction. BP
GO:0043551 regulation of phosphoinositide 3-kinase activity Any process that modulates the frequency, rate or extent of phosphoinositide 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. BP
GO:0016549 tRNA editing The chemical modification of nucleotides within the primary transcript of transfer RNA (tRNA), necessary to form a mature tRNA. BP
GO:0043553 negative regulation of phosphoinositide 3-kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphoinositide 3-kinase activity. BP
GO:0043552 positive regulation of phosphoinositide 3-kinase activity Any process that activates or increases the frequency, rate or extent of phosphoinositide 3-kinase activity. BP
GO:0043555 regulation of translation in response to stress Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). BP
GO:0043554 aerobic respiration, using arsenite as electron donor The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems. BP
GO:0043557 regulation of translation in response to osmotic stress Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. BP
GO:0043556 regulation of translation in response to oxidative stress Modulation of the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. BP
GO:0043559 insulin binding Interacting selectively with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. MF
GO:0043558 regulation of translation initiation in response to stress Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. BP
GO:0016542 male courtship behavior (sensu Insecta) The actions of reactions of a male, for the purpose of attracting a sexual partner. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0016543 male courtship behavior (sensu Insecta), orientation The process during courtship, where the male orients towards a potential partner. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0016544 male courtship behavior (sensu Insecta), tapping The process during courtship where the male taps the female with his frontal leg. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0016545 male courtship behavior (sensu Insecta), wing vibration The process during courtship where the male vibrates his wings. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0016546 male courtship behavior (sensu Insecta), licking The process during courtship where the male licks the genitalia of a stationary female fly with his proboscis. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0016547 RNA editing The insertion, deletion or substitution of nucleotides within nascent RNA transcripts to produce RNA molecules with sequences that differ from those coded genetically. BP
GO:0043089 positive regulation of Cdc42 GTPase activity Any process that activates or increases the activity of the GTPase Cdc42. BP
GO:0043088 regulation of Cdc42 GTPase activity Any process that modulates the activity of the GTPase Cdc42. BP
GO:0043083 synaptic cleft The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. CC
GO:0043082 egg cell nucleus (sensu Viridiplantae) The nucleus of a plant egg cell, the female gamete, at the micropylar end of the embryo and its descendents. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0043081 male germ cell nucleus (sensu Metazoa) The nucleus of the male germ cell, a cell specialized to produce haploid gametes, and its descendents. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). CC
GO:0043080 female germ cell nucleus (sensu Metazoa) The nucleus of the female germ cell, a cell specialized to produce haploid gametes, and its descendents. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). CC
GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. BP
GO:0043086 negative regulation of enzyme activity Any process that stops or reduces the activity of an enzyme. BP
GO:0043085 positive regulation of enzyme activity Any process that activates or increases the activity of an enzyme. BP
GO:0043084 penile erection The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. BP
GO:0002022 detection of dietary excess The mechanism by which the brain senses excessive caloric intake. BP
GO:0009859 pollen hydration The process by which water is taken up by pollen. BP
GO:0002023 reduction of food intake in response to dietary excess The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food. BP
GO:0045869 negative regulation of retroviral genome replication Any process that stops, prevents or reduces the frequency, rate or extent of retroviral genome replication. BP
GO:0045863 negative regulation of pteridine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine. BP
GO:0045862 positive regulation of proteolysis Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. BP
GO:0045861 negative regulation of proteolysis Any process that stops, prevents or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. BP
GO:0045860 positive regulation of protein kinase activity Any process that activates or increases the frequency, rate or extent of protein kinase activity. BP
GO:0045864 positive regulation of pteridine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine. BP
GO:0031284 positive regulation of guanylate cyclase activity Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. BP
GO:0031285 regulation of stalk cell differentiation Any process that modulates the frequency, rate or extent of stalk cell differentiation. BP
GO:0031286 negative regulation of stalk cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of stalk cell differentiation. BP
GO:0031287 positive regulation of stalk cell differentiation Any process that activates or increases the frequency, rate or extent of stalk cell differentiation. BP
GO:0031280 negative regulation of cyclase activity Any process that stops or reduces the activity of a cyclase. BP
GO:0031281 positive regulation of cyclase activity Any process that activates or increases the activity of a cyclase. BP
GO:0031282 regulation of guanylate cyclase activity Any process that modulates the frequency, rate or extent of guanylate cyclase activity. BP
GO:0031283 negative regulation of guanylate cyclase activity Any process that stops, prevents or reduces the frequency, rate or extent of guanylate cyclase activity. BP
GO:0031288 fruiting body morphogenesis (sensu Dictyosteliida) The process by which the fruiting body of cellular slime mold is generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the taxon Dictyosteliida (Dictyosteliida, ncbi_taxonomy_id:33083). BP
GO:0031289 actin phosphorylation The transfer of one or more phosphate groups to an actin molecule. BP
GO:0030489 processing of 27S pre-rRNA NA BP
GO:0030488 tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. BP
GO:0030482 actin cable A long bundle of actin filaments, comprising filamentous actin and associated proteins, found in cells. CC
GO:0030485 smooth muscle contractile fiber The contractile fiber of smooth muscle cells. CC
GO:0030487 inositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the removal of a phosphate group from the carbon-5 position of D-myo-inositol 4,5-bisphosphate. MF
GO:0030486 smooth muscle dense body Electron-dense region associated with a smooth muscle contractile fiber. CC
GO:0015277 kainate selective glutamate receptor activity NA MF
GO:0008987 quinolinate synthetase A activity Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate. MF
GO:0008986 pyruvate, water dikinase activity Catalysis of the reaction: ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate. MF
GO:0008985 pyruvate dehydrogenase (cytochrome) activity Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1. MF
GO:0008984 protein-glutamate methylesterase activity Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. MF
GO:0008983 protein-glutamate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. MF
GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). MF
GO:0008981 protease IV activity NA MF
GO:0008980 propionate kinase activity Catalysis of the reaction: ATP + propionate = ADP + propionate phosphate. MF
GO:0030739 O-demethylpuromycin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin. MF
GO:0030738 tyramine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. MF
GO:0008989 rRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine. MF
GO:0008988 rRNA (adenine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine. MF
GO:0045138 tail tip morphogenesis (sensu Nematoda) The process by which the anatomical structures of the tail tip are generated and organized. Morphogenesis pertains to the creation of form. The tail tip undergoes morphogenesis to form a copulatory structure. The most posterior hypodermal cells in the tail define a specialized, sexually dimorphic compartment in which cells fuse and retract in the male, changing their shape from a tapered cone to a blunt dome. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0005005 transmembrane-ephrin receptor activity NA MF
GO:0045131 pre-mRNA branch point binding Interacting selectively with a pre-mRNA branch point sequence, located upstream of the 3' splice site. MF
GO:0045130 keratan sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. MF
GO:0045133 2,3-dihydroxybenzoate 3,4-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 3-carboxy-2-hydroxymuconate semialdehyde. MF
GO:0045132 meiotic chromosome segregation The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle. BP
GO:0045135 poly(beta-D-mannuronate) lyase activity Catalysis of the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. MF
GO:0045134 uridine-diphosphatase activity Catalysis of the reaction: UDP + H2O = UMP + phosphate. MF
GO:0045137 development of primary sexual characteristics The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. BP
GO:0045136 development of secondary sexual characteristics The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion. BP
GO:0018919 gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health. BP
GO:0018918 gallate metabolic process The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms. BP
GO:0018915 ethylbenzene metabolic process The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels. BP
GO:0018914 chlorobenzene metabolic process The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone. BP
GO:0018917 fluorene metabolic process The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents. BP
GO:0018916 nitrobenzene metabolic process The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline. BP
GO:0018911 1,2,4-trichlorobenzene metabolic process The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides. BP
GO:0018910 benzene metabolic process The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation. BP
GO:0018913 anaerobic ethylbenzene metabolic process The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen. BP
GO:0018912 1,4-dichlorobenzene metabolic process The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs. BP
GO:0008363 larval cuticle biosynthetic process (sensu Insecta) Synthesis and deposition of a larval cuticle as in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. BP
GO:0008362 embryonic cuticle biosynthetic process (sensu Insecta) Synthesis and deposition of an embryonic cuticle by the underlying epidermal epithelium, as in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). This tough, waterproof layer is essential to provide structural integrity of the larval body. BP
GO:0008361 regulation of cell size Any process that modulates the size of a cell. BP
GO:0008360 regulation of cell shape Any process that modulates the shape of a cell. BP
GO:0008367 bacterial binding Interacting selectively with any part of a bacterial cell. MF
GO:0008366 axon ensheathment The processes by which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. BP
GO:0008365 adult cuticle biosynthetic process (sensu Insecta) Synthesis and deposition of the cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0008364 pupal cuticle biosynthetic process (sensu Insecta) Synthesis and deposition of a pupal cuticle as in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. BP
GO:0008368 Gram-negative bacterial binding Interacting selectively with any part of a Gram-negative bacterial cell. MF
GO:0040040 thermosensory behavior Behavior that is dependent upon the sensation of temperature. BP
GO:0032252 secretory granule localization The processes by which a secretory granule is transported to, and/or maintained in, a specific location within the cell. BP
GO:0032253 dense core granule localization The processes by which a dense core granule is transported to, and/or maintained in, a specific location within the cell. BP
GO:0032250 negative regulation of adenosine transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells. BP
GO:0032251 positive regulation of adenosine transport Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells. BP
GO:0032256 establishment of dense core granule localization The directed movement of a dense core granule to a specific location. BP
GO:0032257 maintenance of dense core granule localization The processes by which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0032254 establishment of secretory granule localization The directed movement of a secretory granule to a specific location. BP
GO:0032255 maintenance of secretory granule localization The processes by which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0032258 CVT pathway A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast. BP
GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. BP
GO:0005845 mRNA cap complex Any complex that binds to an mRNA cap at any time in the lifetime of the mRNA. CC
GO:0051445 regulation of progression through meiotic cell cycle Any process that modulates the rate or extent of progression through the mitotic cell cycle. BP
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. CC
GO:0005917 nephrocyte junction A tissue-specific adherens junction found in kidney cells. CC
GO:0005916 fascia adherens A broad intercellular junction in the intercalated disk of cardiac muscle that anchors actin filaments. CC
GO:0005915 zonula adherens Cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. CC
GO:0005846 snRNA cap binding complex NA CC
GO:0005913 cell-cell adherens junction An adherens junction which connects two cells to each other. CC
GO:0005912 adherens junction A cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. CC
GO:0005911 intercellular junction A specialized region of connection between two cells including but not limited to gap junctions, desmosomes, and tight junctions, but excluding direct cytoplasmic junctions such as ring canals. CC
GO:0005919 pleated septate junction A septate junction in which regular arrays of electron-dense septae span the intermembrane space. CC
GO:0005918 septate junction Invertebrate-specific cell-cell junctions which form a band around the apical borders of epithelial cells and attach to actin filaments. CC
GO:0005843 cytosolic small ribosomal subunit (sensu Eukaryota) The small subunit of a eukaryotic cytosolic ribosome; has a sedimentation coefficient of 40S. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0018076 N-terminal peptidyl-lysine acetylation The acetylation of the N-terminal lysine of proteins. BP
GO:0005842 cytosolic large ribosomal subunit (sensu Eukaryota) The large subunit of a ribosome; has a sedimentation coefficient of 60S. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0051448 gonadotropin-releasing hormone binding Interacting selectively with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus. MF
GO:0051449 thyrotropin-releasing hormone binding Interacting selectively with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system. MF
GO:0042358 thiamin diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. BP
GO:0042359 vitamin D metabolic process The chemical reactions and pathways involving vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol. BP
GO:0042354 L-fucose metabolic process The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. BP
GO:0042355 L-fucose catabolic process The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). BP
GO:0042356 GDP-4-dehydro-D-rhamnose reductase activity Catalysis of the reaction: GDP-6-deoxy-D-mannose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+. MF
GO:0042357 thiamin diphosphate metabolic process The chemical reactions and pathways involving thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. BP
GO:0042350 GDP-L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. BP
GO:0042351 'de novo' GDP-L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271). BP
GO:0042352 GDP-L-fucose salvage The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30). BP
GO:0042353 fucose biosynthetic process The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose). BP
GO:0006242 dCTP biosynthetic process The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate. BP
GO:0006243 CTP deamination NA BP
GO:0006240 dCDP biosynthetic process The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate. BP
GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. BP
GO:0006246 dTDP catabolic process The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate. BP
GO:0006244 pyrimidine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0006245 TDP catabolic process The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate. BP
GO:0006248 CMP catabolic process The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate. BP
GO:0006249 dCMP catabolic process The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate. BP
GO:0000374 Group III intron splicing The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensu thes sequences are not as well conserved. BP
GO:0000375 RNA splicing, via transesterification reactions Splicing of RNA via a series of two transesterification reactions. BP
GO:0000376 RNA splicing, via transesterification reactions with guanosine as nucleophile Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile. BP
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. BP
GO:0000370 U2-type nuclear mRNA branch site recognition Recognition of the intron branch site sequence of a U2-type intron. This recognition may include an interaction between the U2 snRNA (as part of the U2 snRNP) and the branch site sequence of the pre-mRNA. In cis-splicing, the U1 snRNP, already associated with the 5'-splice site may also be involved in recruiting the U2 snRNP to the branch site. BP
GO:0000371 U12-type nuclear mRNA branch site recognition Recognition of the intron branch site sequence of a U12-type intron. The U12 snRNP is thought to play a role in this via an interaction between the U12 snRNA and the branch site sequence of the pre-mRNA. BP
GO:0000372 Group I intron splicing The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensu thes splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize). BP
GO:0000373 Group II intron splicing The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensu thes sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. BP
GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bound subcellular organelles. Usually requires an organelle specific protein sequence motif. BP
GO:0000378 RNA exon ligation The process of joining two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction. BP
GO:0000379 tRNA-type intron splice site recognition and cleavage The process of recognition of the tertiary structure of a tRNA type intron and the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites. BP
GO:0006794 phosphorus utilization NA BP
GO:0006795 regulation of phosphorus utilization Any process that modulates the frequency, rate or extent of phosphorus utilization. BP
GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. BP
GO:0006797 polyphosphate metabolic process The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid. BP
GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. BP
GO:0006791 sulfur utilization NA BP
GO:0006792 regulation of sulfur utilization Any process that modulates the frequency, rate or extent of sulfur utilization. BP
GO:0006793 phosphorus metabolic process The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). BP
GO:0006798 polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid. BP
GO:0006799 polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. BP
GO:0048675 axon extension Long distance growth of a single process. BP
GO:0048674 collateral sprouting of injured axon The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process by which outgrowths develop from the shafts of existing axons. BP
GO:0048677 axon extension involved in regeneration Long distance growth of a single axon process involved in regeneration of the neuron. BP
GO:0048676 axon extension involved in development Long distance growth of a single axon process involved in cellular development. BP
GO:0048671 negative regulation of collateral sprouting Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting. BP
GO:0048670 regulation of collateral sprouting Any process that modulates the frequency, rate or extent of collateral sprouting. BP
GO:0048673 collateral sprouting of intact axon in response to injury The process by which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input. BP
GO:0048672 positive regulation of collateral sprouting Any process that activates or increases the frequency, rate or extent of collateral sprouting. BP
GO:0000086 G2/M transition of mitotic cell cycle Progression from G2 phase to M phase of the mitotic cell cycle. BP
GO:0000087 M phase of mitotic cell cycle Progression through M phase, the part of the mitotic cell cycle during which mitosis and cytokinesis take place. BP
GO:0000084 S phase of mitotic cell cycle Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place. BP
GO:0000085 G2 phase of mitotic cell cycle Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis. BP
GO:0000082 G1/S transition of mitotic cell cycle Progression from G1 phase to S phase of the mitotic cell cycle. BP
GO:0048678 response to axon injury A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. BP
GO:0000080 G1 phase of mitotic cell cycle Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis. BP
GO:0004798 thymidylate kinase activity Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. MF
GO:0004799 thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. MF
GO:0004796 thromboxane-A synthase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromba-5,13-dienoate. MF
GO:0004797 thymidine kinase activity Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. MF
GO:0004794 threonine ammonia-lyase activity Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. MF
GO:0004795 threonine synthase activity Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. MF
GO:0004792 thiosulfate sulfurtransferase activity Catalysis of the reaction: thiosulfate + cyanide = SO3(2-) (sulfite) + thiocyanate. MF
GO:0004793 threonine aldolase activity Catalysis of the reaction: L-threonine = glycine + acetaldehyde. MF
GO:0004790 thioether S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. MF
GO:0004791 thioredoxin-disulfide reductase activity Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+. MF
GO:0050728 negative regulation of inflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of the inflammatory response. BP
GO:0050729 positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response. BP
GO:0050722 regulation of interleukin-1 beta biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta. BP
GO:0050723 negative regulation of interleukin-1 alpha biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha. BP
GO:0050720 interleukin-1 beta biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-1 beta. BP
GO:0050721 regulation of interleukin-1 alpha biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha. BP
GO:0050726 positive regulation of interleukin-1 alpha biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha. BP
GO:0050727 regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. BP
GO:0050724 negative regulation of interleukin-1 beta biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta. BP
GO:0050725 positive regulation of interleukin-1 beta biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta. BP
GO:0004138 deoxyguanosine kinase activity Catalysis of the reaction: ATP + deoxyguanosine = ADP + dGMP. MF
GO:0004139 deoxyribose-phosphate aldolase activity Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. MF
GO:0004132 dCMP deaminase activity Catalysis of the reaction: dCMP + H2O = dUMP + NH3. MF
GO:0004133 glycogen debranching enzyme activity Catalysis of the cleavage of branch points in branched glycogen polymers. MF
GO:0004130 cytochrome-c peroxidase activity Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O. MF
GO:0004131 cytosine deaminase activity Catalysis of the reaction: cytosine + H2O = uracil + NH3. MF
GO:0004136 deoxyadenosine kinase activity Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP. MF
GO:0004137 deoxycytidine kinase activity Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. MF
GO:0004134 4-alpha-glucanotransferase activity Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan. MF
GO:0004135 amylo-alpha-1,6-glucosidase activity Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present. MF
GO:0007539 primary sex determination, soma The transmission of information about sexual status from the initial, general, determination to signals specific to the soma. BP
GO:0007538 primary sex determination NA BP
GO:0007537 inactivation of recombination (HML) The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. BP
GO:0007536 activation of recombination (HML) The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. BP
GO:0007535 donor selection The process by which a cell uses one locus in preference to another as the donor in mating type switching. BP
GO:0007534 gene conversion at mating-type locus The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged. BP
GO:0007533 mating type switching The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. BP
GO:0007532 regulation of transcription, mating-type specific Any mating-type specific process that modulates the frequency, rate or extent of transcription. BP
GO:0007531 mating type determination Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms. BP
GO:0007530 sex determination Any process that establishes and transmits the specification of sexual status of an individual organism. BP
GO:0001562 response to protozoan A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. BP
GO:0001563 detection of protozoan The series of events in which a stimulus from a protozoan is received and converted into a molecular signal. BP
GO:0001560 regulation of cell growth by extracellular stimulus Any process whereby external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. BP
GO:0001561 fatty acid alpha-oxidation Pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway. BP
GO:0001566 non-kinase phorbol ester receptor activity Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity. MF
GO:0001567 cholesterol 25-hydroxylase activity Catalysis of the hydroxylation of cholesterol at position 25 of the side chain, to produce 25-hydroxycholesterol. MF
GO:0001565 phorbol ester receptor activity Combining with a phorbol ester to initiate a change in cell activity. MF
GO:0001568 blood vessel development The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. BP
GO:0001569 patterning of blood vessels The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. BP
GO:0016708 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen is incorporated into one donor. MF
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. MF
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. MF
GO:0016707 gibberellin 3-beta-dioxygenase activity Catalysis of the reaction: gibberellin 20 + 2-oxoglutarate + O2 = gibberellin 1 + succinate + CO2. MF
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. MF
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. MF
GO:0016703 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor. MF
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. MF
GO:0019709 iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. BP
GO:0019708 peptidyl-glycine cholesteryl ester biosynthetic process from peptidyl-glycine The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins. BP
GO:0019707 protein-cysteine S-acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule. MF
GO:0019706 protein-cysteine S-palmitoleyltransferase activity Catalysis of the transfer of an palmitoleyl group to a sulfur atom on the cysteine of a protein molecule. MF
GO:0019705 protein-cysteine S-myristoyltransferase activity Catalysis of the transfer of an myristoyl group to a sulfur atom on the cysteine of a protein molecule. MF
GO:0019704 peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine. BP
GO:0019703 coenzyme A-peptidyl-cysteine covalent linking The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide. BP
GO:0019702 protein-arginine N5-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. MF
GO:0019701 peptidyl-arginine N5-methylation The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine. BP
GO:0019700 phosphonate catabolic process The chemical reactions and pathways resulting in the breakdown of phosphonates, any salt, anion, or ester of phosphonic acid (HPO(OH)2). BP
GO:0015941 pantothenate catabolic process The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. BP
GO:0015940 pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. BP
GO:0015943 formate biosynthetic process The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. BP
GO:0015942 formate metabolic process The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. BP
GO:0015945 methanol metabolic process The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. BP
GO:0015944 formate oxidation NA BP
GO:0015947 methane metabolic process The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. BP
GO:0015946 methanol oxidation NA BP
GO:0015949 nucleobase, nucleoside and nucleotide interconversion NA BP
GO:0015948 methanogenesis The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. BP
GO:0045053 protein retention in Golgi The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known. BP
GO:0009210 pyrimidine ribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009212 pyrimidine deoxyribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009214 cyclic nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. BP
GO:0009215 purine deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009216 purine deoxyribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009217 purine deoxyribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009218 pyrimidine ribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009219 pyrimidine deoxyribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0045055 regulated secretory pathway The regulated secretory pathway is a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. BP
GO:0065010 extracellular membrane-bound organelle Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. CC
GO:0008160 protein tyrosine phosphatase activator activity Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein. MF
GO:0008169 C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. MF
GO:0008168 methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule. MF
GO:0055026 negative regulation of cardiac muscle development Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle development. BP
GO:0055024 regulation of cardiac muscle development Any process that modulates the frequency, rate or extent of cardiac muscle development. BP
GO:0055025 positive regulation of cardiac muscle development Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle development. BP
GO:0055022 negative regulation of cardiac muscle growth Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle growth. BP
GO:0055023 positive regulation of cardiac muscle growth Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. BP
GO:0055020 positive regulation of cardiac muscle fiber development Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. BP
GO:0045238 CXCR2 chemokine receptor binding Interacting selectively with the CXCR2 chemokine receptor. MF
GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. CC
GO:0045236 CXCR chemokine receptor binding Interacting selectively with a chemokine receptor in the CXCR family. MF
GO:0045237 CXCR1 chemokine receptor binding Interacting selectively with the CXCR1 chemokine receptor. MF
GO:0045234 protein palmitoleylation The covalent or non-covalent attachment of a palmitoleyl moiety to a protein. BP
GO:0045235 protein amino acid palmitoleylation The covalent or non-covalent attachment of a palmitoleyl moiety to a protein amino acid. BP
GO:0045232 S-layer organization and biogenesis The assembly and arrangement of an S-layer enveloping the cell. BP
GO:0045233 natural killer cell receptor activity A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family. MF
GO:0045230 capsule organization and biogenesis The assembly and arrangement of the capsule, a protective structure surrounding some species of bacteria and fungi. BP
GO:0045231 slime layer organization and biogenesis The assembly and arrangement of a slime layer enveloping the cell. BP
GO:0045580 regulation of T cell differentiation Any process that modulates the frequency, rate or extent of T cell differentiation. BP
GO:0045581 negative regulation of T cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation. BP
GO:0045582 positive regulation of T cell differentiation Any process that activates or increases the frequency, rate or extent of T cell differentiation. BP
GO:0045583 regulation of cytotoxic T cell differentiation Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation. BP
GO:0045584 negative regulation of cytotoxic T cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation. BP
GO:0045585 positive regulation of cytotoxic T cell differentiation Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation. BP
GO:0045586 regulation of gamma-delta T cell differentiation Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation. BP
GO:0045587 negative regulation of gamma-delta T cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell differentiation. BP
GO:0045588 positive regulation of gamma-delta T cell differentiation Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation. BP
GO:0045589 regulation of regulatory T cell differentiation Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. BP
GO:0015116 sulfate transporter activity Enables the directed movement of sulfate ions (SO4 2-) into, out of, within or between cells. MF
GO:0015117 thiosulfate transporter activity Enables the directed movement of thiosulfate ions (S2O3 2-) into, out of, within or between cells. MF
GO:0015114 phosphate transporter activity Enables the directed movement of phosphate (PO4 3-) ions into, out of, within or between cells. MF
GO:0015115 silicate transporter activity Enables the directed movement of silicates into, out of, within or between cells. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. MF
GO:0015112 nitrate transporter activity Enables the directed movement of nitrate ions (NO3-) into, out of, within or between cells. MF
GO:0015113 nitrite transporter activity Enables the directed movement of nitrite (NO2(-)) ions into, out of, within or between cells. MF
GO:0015110 cyanate transporter activity Enables the directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of, within or between cells. MF
GO:0015111 iodide transporter activity Enables the directed movement of iodide ions into, out of, within or between cells. MF
GO:0015118 tellurite transporter activity Enables the directed movement of tellurite into, out of, within or between cells. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals. MF
GO:0015119 hexose phosphate transporter activity Enables the directed movement of hexose phosphate into, out of, within or between cells. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule. MF
GO:0042004 feminization of hermaphrodite soma (sensu Nematoda) Promotion of female sex and sexual phenotypes in the hermaphroditic soma, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0042005 hermaphrodite germ-line sex determination (sensu Nematoda) The determination of sex and sexual phenotype in the germ line of a hermaphrodite, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0042006 masculinization of hermaphroditic germ-line (sensu Nematoda) The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0047035 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity Catalysis of the reaction: NAD+ + testosterone = NADH + H+ + androst-4-ene-3,17-dione. MF
GO:0042000 translocation of peptides or proteins into host The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042001 hermaphrodite somatic sex determination The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. BP
GO:0035060 brahma complex A multi-subunit ATP-dependent chromatin remodeling complex, a counterpart of the SWI/SNF complex that contains the ATPase product of the Drosophila brahma gene. CC
GO:0035061 interchromatin granule A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs). CC
GO:0035062 omega speckle A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs). CC
GO:0035063 nuclear speck organization and biogenesis The assembly and arrangement of nuclear specks, a class of nuclear body in which splicing factors are localized. BP
GO:0035064 methylated histone residue binding Interacting selectively with a methylated residue on a histone protein. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. MF
GO:0035065 regulation of histone acetylation Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein. BP
GO:0035066 positive regulation of histone acetylation Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. BP
GO:0035067 negative regulation of histone acetylation Any process that stops, prevents or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. BP
GO:0035068 micro-ribonucleoprotein complex A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA. CC
GO:0035069 larval midgut histolysis The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. BP
GO:0042003 masculinization of hermaphrodite soma (sensu Nematoda) Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0031987 locomotion during locomotory behavior Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. BP
GO:0031986 proteinoplast A leucoplast in which protein is stored. CC
GO:0031985 Golgi cisterna Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. CC
GO:0031984 organelle subcompartment A membrane-enclosed compartment that is a part of an organelle. CC
GO:0031983 vesicle lumen The volume enclosed by the membrane or protein that forms a vesicle. CC
GO:0031982 vesicle Any small, fluid-filled, spherical organelle enclosed by membrane or protein. CC
GO:0031981 nuclear lumen The volume enclosed by the nuclear inner membrane. CC
GO:0031980 mitochondrial lumen The volume enclosed by the mitochondrial inner membrane. CC
GO:0031989 bombesin receptor signaling pathway The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands. BP
GO:0031988 membrane-bound vesicle Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer. CC
GO:0043326 chemotaxis to folate The directed movement of a motile cell or organism in response to the presence of folate. BP
GO:0043327 chemotaxis to cAMP The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP. BP
GO:0043324 pigment metabolic process during developmental pigmentation The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin, occurring during the deposition of coloring matter in an organ or organism. BP
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding Interacting selectively with phosphatidylinositol-3,4-bisphosphate, a diphosphorylated derivative of phosphatidylinositol. MF
GO:0043322 negative regulation of natural killer cell degranulation Any process that stops, prevents, or reduces the rate of mast cell degranulation. BP
GO:0043323 positive regulation of natural killer cell degranulation Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation. BP
GO:0043320 natural killer cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell. BP
GO:0043321 regulation of natural killer cell degranulation Any process that modulates the frequency, rate, or extent of natural killer cell degranulation. BP
GO:0043328 protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway The process of directing proteins towards the vacuole using signals contained within the protein, occurring during protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway. BP
GO:0043329 protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway The process of directing proteins towards a membrane using signals contained within the protein, occurring during ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway. BP
GO:0009979 16:0 monogalactosyldiacylglycerol desaturase activity NA MF
GO:0009978 allene oxide synthase activity Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O. MF
GO:0009975 cyclase activity Catalysis of a ring closure reaction. MF
GO:0009974 epsilon hydroxylase activity Catalysis of the hydroxylation of zeinoxanthin to lutein. Adds hydroxy group to the epsilon ring of the alpha-carotene. MF
GO:0009977 delta-pH-dependent transporter activity Transports proteins across membranes and transportation is dependent on pH gradient across the membranes. MF
GO:0009976 tocopherol cyclase activity Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol). MF
GO:0009971 male meiotic spindle assembly (sensu Viridiplantae) The formation of the spindle in male meiotic cells. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). BP
GO:0009970 cellular response to sulfate starvation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate. BP
GO:0009973 adenylyl-sulfate reductase activity Catalysis of the reaction: AMP + SO3(2-) (sulfite) + acceptor = adenylyl sulfate + reduced acceptor. MF
GO:0009972 cytidine deamination The removal of amino group in the presence of water. BP
GO:0031363 N-terminal protein amino acid deamination The removal of an amino group from the N-terminal amino acid residue of a protein. BP
GO:0031362 anchored to external side of plasma membrane Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane. CC
GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031360 intrinsic to thylakoid membrane Located in a thylakoid membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031367 N-terminal peptidyl-glutamine deamination The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein. BP
GO:0031366 N-terminal peptidyl-arginine deamination The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein. BP
GO:0031365 N-terminal protein amino acid modification The alteration of the N-terminal amino acid residue in a protein. BP
GO:0031364 N-terminal protein amino acid deamination, from side chain The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein. BP
GO:0031369 translation initiation factor binding Interacting selectively with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. MF
GO:0031368 Pro-X metallocarboxypeptidase activity Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid. MF
GO:0042749 regulation of circadian sleep/wake cycle Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. BP
GO:0042748 circadian sleep/wake cycle, non-REM sleep All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions. BP
GO:0019229 regulation of vasoconstriction Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. BP
GO:0048479 style development The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma. BP
GO:0048478 replication fork protection Processes preventing the collapse of stalled replication forks. BP
GO:0048473 D-methionine transport The directed movement of D-methionine into, out of, within, or between cells. BP
GO:0048472 threonine-phosphate decarboxylase activity Catalysis of the reaction: L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2. MF
GO:0048471 perinuclear region Cytoplasm situated near, or occurring around, the nucleus. CC
GO:0048477 oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. BP
GO:0048476 Holliday junction resolvase complex An endonuclease complex that resolves Holliday junctions by a nick and counternick mechanism. CC
GO:0048475 coated membrane A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. CC
GO:0048474 D-methionine transporter activity Enables the directed movement of D-methionine into, out of, within, or between cells. MF
GO:0050449 casbene synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = casbene + diphosphate. MF
GO:0050448 beta-cyclopiazonate dehydrogenase activity Catalysis of the reaction: beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor. MF
GO:0050442 3-propylmalate synthase activity Catalysis of the reaction: pentanoyl-CoA + H2O + glyoxylate = 3-propylmalate + CoA . MF
GO:0050441 3-ethylmalate synthase activity Catalysis of the reaction: butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA . MF
GO:0050440 2-methylcitrate synthase activity Catalysis of the reaction: propanoyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA. MF
GO:0050447 zeatin 9-aminocarboxyethyltransferase activity Catalysis of the reaction: O-acetyl-L-serine + zeatin = lupinate + acetate. MF
GO:0050446 azobenzene reductase activity Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+. MF
GO:0050445 asparagusate reductase activity Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + NADH + H+. MF
GO:0050444 aquacobalamin reductase (NADPH) activity Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+. MF
GO:0031352 intrinsic to plastid inner membrane Located in a plastid inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031353 integral to plastid inner membrane Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031350 intrinsic to plastid membrane Located in a plastid membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031351 integral to plastid membrane Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031356 intrinsic to chloroplast inner membrane Located in the chloroplast inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031357 integral to chloroplast inner membrane Penetrating at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031354 intrinsic to plastid outer membrane Located in a plastid outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031355 integral to plastid outer membrane Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0018898 2,4-dichlorobenzoate metabolic process The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs). BP
GO:0018899 1,2-dichloroethane metabolic process The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride. BP
GO:0018890 cyanamide metabolic process The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism. BP
GO:0018891 cyclohexanol metabolic process The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent. BP
GO:0018892 cyclohexylsulfamate metabolic process The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide. BP
GO:0018893 dibenzofuran metabolic process The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals. BP
GO:0018894 dibenzo-p-dioxin metabolic process The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern. BP
GO:0018895 dibenzothiophene metabolic process The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion. BP
GO:0018896 dibenzothiophene catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. BP
GO:0018897 dibenzothiophene desulfurization The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. BP
GO:0032043 mitochondrial DNA catabolic process The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA. BP
GO:0032042 mitochondrial DNA metabolic process The chemical reactions and pathways involving mitochondrial DNA. BP
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 14 of the histone H3 protein. MF
GO:0032040 small subunit processome A large ribonuclear protein complex containing the U3 snoRNA and associated proteins (28 in S. cerevisiae) that is involved in processing of the pre-18S rRNA to form the small ribosomal subunit. CC
GO:0032047 mitosome A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. CC
GO:0032046 micropexophagy-specific membrane apparatus A membrane-bound flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole. CC
GO:0032045 guanyl-nucleotide exchange factor complex A protein complex that stimulates the exchange of guanyl nucleotides by a GTPase. CC
GO:0032044 DSIF complex A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions. CC
GO:0032049 cardiolipin biosynthetic process The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. BP
GO:0032048 cardiolipin metabolic process The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. BP
GO:0000943 retrotransposon nucleocapsid A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog. CC
GO:0000942 outer kinetochore of condensed nuclear chromosome The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. CC
GO:0000941 inner kinetochore of condensed nuclear chromosome The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. CC
GO:0000940 outer kinetochore of condensed chromosome The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. CC
GO:0019277 UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0019276 UDP-N-acetylgalactosamine metabolic process The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0019275 phenylalanine biosynthetic process, shikimate pathway The chemical reactions and pathways resulting in the formation of phenylalanine, an aromatic amino acid through shikimate pathway. BP
GO:0019274 phenylalanine biosynthetic process, prephenate pathway The chemical reactions and pathways resulting in the formation of phenylalanine that occurs in the prephenate pathway. BP
GO:0019273 L-alanine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine. BP
GO:0019272 L-alanine biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate. BP
GO:0019271 aerobactin transport The directed movement of the hydroxamate iron transport compound aerobactin into, out of, within or between cells. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. BP
GO:0019270 aerobactin biosynthetic process The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. BP
GO:0019279 methionine biosynthetic process from L-homoserine via cystathione The chemical reactions and pathways resulting in the formation of methionine from other compounds, including L-homoserine, via the intermediate cystathione. BP
GO:0019278 UDP-N-acetylgalactosamine catabolic process The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0019853 L-ascorbic acid biosynthetic process The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. BP
GO:0019852 L-ascorbic acid metabolic process The chemical reactions and pathways involving L-ascorbic acid, a carbohydrate-like vitamin containing six carbon atoms per molecule. Widely distributed in fruit and vegetables. BP
GO:0019851 D-tyrosyl-tRNA hydrolase activity NA MF
GO:0019857 5-methylcytosine metabolic process The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA. BP
GO:0019856 pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases. BP
GO:0019855 calcium channel inhibitor activity The inhibition of the passage of calcium ions through a calcium channel; the function of some venoms. MF
GO:0019854 L-ascorbic acid catabolic process The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. BP
GO:0019859 thymine metabolic process The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. BP
GO:0019858 cytosine metabolic process The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. BP
GO:0060017 parathyroid gland development The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone. BP
GO:0060016 granulosa cell development The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate. BP
GO:0060015 granulosa cell fate commitment The cell fate commitment of precursor cells that will become granulosa cells. BP
GO:0060014 granulosa cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals. BP
GO:0060013 righting reflex A reflex process in which an animal immediately tries to turn over after being placed in a supine position. BP
GO:0060012 synaptic transmission, glycinergic The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. BP
GO:0060011 Sertoli cell proliferation The multiplication or reproduction of Sertoli cells, resulting in the rapid expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. BP
GO:0060010 Sertoli cell fate commitment The process by which the cellular identity of Sertoli cells is acquired and determined. BP
GO:0060019 radial glial cell differentiation The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0060018 astrocyte fate commitment The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte. BP
GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. BP
GO:0006451 translational readthrough The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UGA codon as a modified amino acid, rather than as a termination codon. BP
GO:0006450 regulation of translational fidelity Any process that modulates the frequency, rate or extent of activities to ensure translational fidelity. BP
GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. BP
GO:0006458 'de novo' protein folding The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. BP
GO:0035309 wing and notum subfield formation The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures. BP
GO:0035308 negative regulation of protein amino acid dephosphorylation Any process the stops, prevents or reduces the frequency, rate or extent of removal of phosphoric groups from a protein. BP
GO:0035301 Hedgehog signaling complex A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila). CC
GO:0035300 inositol trisphosphate 5/6-kinase activity Catalysis of the reactions: inositol 1,3,4-trisphosphate + ATP = inositol 1,3,4,5-tetrakisphosphate + ADP, and inositol 1,3,4-trisphosphate + ATP = inositol 1,3,4,6-tetrakisphosphate + ADP. MF
GO:0035303 regulation of dephosphorylation Any process that modulates the frequency, rate or extent of removal of phosphoric groups from a molecule. BP
GO:0035302 ecdysteroid 25-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods. MF
GO:0035305 negative regulation of dephosphorylation Any process the stops, prevents or reduces the frequency, rate or extent of removal of phosphoric groups from a molecule. BP
GO:0035304 regulation of protein amino acid dephosphorylation Any process that modulates the frequency, rate or extent of removal of phosphoric groups from a protein. BP
GO:0035307 positive regulation of protein amino acid dephosphorylation Any process that activates or increases the frequency, rate or extent of removal of phosphoric groups from a protein. BP
GO:0035306 positive regulation of dephosphorylation Any process that activates or increases the frequency, rate or extent of removal of phosphoric groups from a molecule. BP
GO:0000125 PCAF complex A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs. CC
GO:0000124 SAGA complex A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. CC
GO:0000127 transcription factor TFIIIC complex A heterotrimeric transcription factor for eukaryotic RNA polymerase III promoters. CC
GO:0000126 transcription factor TFIIIB complex A transcription factor for eukaryotic RNA polymerase III promoters that is an RNA polymerase binding protein. CC
GO:0000121 glycerol-1-phosphatase activity Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate. MF
GO:0000120 RNA polymerase I transcription factor complex A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I. CC
GO:0000123 histone acetyltransferase complex Complex that possesses histone acetyltransferase activity. CC
GO:0000122 negative regulation of transcription from RNA polymerase II promoter Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. BP
GO:0000128 flocculation Non-sexual aggregation of single-celled organisms in culture. BP
GO:0032200 telomere organization and biogenesis The assembly and arrangement of telomeres, terminal regions of a linear chromosome that includes the telomeric DNA repeats and associated proteins. BP
GO:0017082 mineralocorticoid receptor activity Combining with mineralocorticoid to initiate a change in cell activity. MF
GO:0007478 leg disc morphogenesis The process by which the anatomical structures derived from the leg disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura. BP
GO:0007479 leg disc proximal/distal pattern formation The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg. BP
GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. MF
GO:0007472 wing disc morphogenesis The process by which the anatomical structures derived from the wing disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura. BP
GO:0007473 wing disc proximal/distal pattern formation The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing. BP
GO:0007470 prothoracic disc morphogenesis The process by which the anatomical structures derived from the prothoracic disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle. BP
GO:0007476 wing morphogenesis The process by which the anatomical structures of the wing are generated and organized. Morphogenesis pertains to the creation of form. The wing is an appendage modified for flying. BP
GO:0017080 sodium channel regulator activity NA MF
GO:0007474 wing vein specification The regionalization process by which the area of a wing that will form a wing vein is specified. BP
GO:0007475 apposition of dorsal and ventral wing surfaces The coming together of the dorsal and ventral surfaces of the wing during the conversion of a folded single layered wing disc to a flat bilayered wing. BP
GO:0015354 polyspecific organic cation transporter activity NA MF
GO:0010187 negative regulation of seed germination Any process that stops, prevents or reduces the frequency, rate or extent of seed germination. BP
GO:0010184 cytokinin transport The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of, within or between cells. BP
GO:0010185 regulation of cellular defense response Any process that modulates the frequency, rate or extent of cellular defense response. BP
GO:0015350 methotrexate transporter activity Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. MF
GO:0015351 bilirubin porter activity NA MF
GO:0015352 sterol porter activity NA MF
GO:0010181 FMN binding Interacting selectively with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. MF
GO:0017086 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamin diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate. CC
GO:0015359 amino acid permease activity Catalysis of the stereospecific transfer of amino acids, organic acids containing one or more amino substituents, across a biological membrane. MF
GO:0010188 response to microbial phytotoxin A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants. BP
GO:0051966 regulation of synaptic transmission, glutamatergic Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. BP
GO:0021911 retinoic acid metabolic process in spinal cord anterior-posterior patterning The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. BP
GO:0021910 smoothened signaling pathway in ventral spinal cord patterning The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. BP
GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord. BP
GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord. BP
GO:0021915 neural tube development The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. BP
GO:0051965 positive regulation of synaptogenesis Any process that activates, maintains or increases the frequency, rate or extent of synaptogenesis, the formation of a synapse. BP
GO:0021917 somatic motor neuron fate commitment The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons. BP
GO:0021916 inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis. BP
GO:0021919 BMP signaling pathway in spinal cord dorsal-ventral patterning A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. BP
GO:0021918 regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis. BP
GO:0017085 response to insecticide A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. BP
GO:0051578 Mrf4 binding Interacting selectively with the muscle regulatory factor Mrf4. MF
GO:0051579 myogenin binding Interacting selectively with the muscle regulatory factor myogenin. MF
GO:0051570 regulation of histone H3-K9 methylation Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. BP
GO:0051571 positive regulation of histone H3-K4 methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. BP
GO:0051572 negative regulation of histone H3-K4 methylation Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. BP
GO:0051573 negative regulation of histone H3-K9 methylation Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. BP
GO:0051574 positive regulation of histone H3-K9 methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. BP
GO:0051575 5'-deoxyribose-5-phosphate lyase activity Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. MF
GO:0051576 Myf5 binding Interacting selectively with the muscle regulatory factor Myf5. MF
GO:0051577 MyoD binding Interacting selectively with the muscle regulatory factor MyoD. MF
GO:0017089 glycolipid transporter activity Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. MF
GO:0031040 micronucleus A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell. CC
GO:0018669 3-hydroxybenzoate 6-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O. MF
GO:0018668 3-hydroxybenzoate 4-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O. MF
GO:0018667 cyclohexanone monooxygenase activity Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O. MF
GO:0018666 2,4-dichlorophenol 6-monooxygenase activity Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O. MF
GO:0018665 4-hydroxyphenylacetate 1-monooxygenase activity Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O. MF
GO:0018664 benzoate 4-monooxygenase activity Catalysis of the reaction: benzoate + NADPH + H+ + O2 = 4-hydroxybenzoate + NADP+ + H2O. MF
GO:0018663 2,6-dihydroxypyridine 3-monooxygenase activity Catalysis of the reaction: 2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O. MF
GO:0018662 phenol 2-monooxygenase activity Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O. MF
GO:0018661 orcinol 2-monooxygenase activity Catalysis of the reaction: orcinol + NADH + H+ + O2 = 2,3,5-trihydroxytoluene + NAD+ + H2O. MF
GO:0018660 4-hydroxyphenylacetate 3-monooxygenase activity Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O. MF
GO:0019138 ribosylhomocysteinase activity Catalysis of the reaction: S-ribosyl-L-homocysteine + H2O = D-ribose + L-homocysteine. MF
GO:0019139 cytokinin dehydrogenase activity Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. MF
GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + D-glucosamine 1-phosphate = CoA + N-acetyl-D-glucosamine 1-phosphate. MF
GO:0019135 deoxyhypusine monooxygenase activity Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. MF
GO:0019136 deoxynucleoside kinase activity Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. MF
GO:0019137 thioglucosidase activity Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar. MF
GO:0019131 tripeptidyl-peptidase I activity Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH. MF
GO:0019132 C-terminal processing peptidase activity Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. MF
GO:0019133 choline monooxygenase activity Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O. MF
GO:0001928 regulation of exocyst assembly Any process that modulates the frequency, rate or extent of exocyst assembly. BP
GO:0001929 negative regulation of exocyst assembly Any process that stops, prevents or reduces the rate or extent of exocyst assembly. BP
GO:0030210 heparin biosynthetic process The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. BP
GO:0030211 heparin catabolic process The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. BP
GO:0030212 hyaluronan metabolic process The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. BP
GO:0030213 hyaluronan biosynthetic process The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. BP
GO:0030214 hyaluronan catabolic process The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. BP
GO:0030215 semaphorin receptor binding Interacting selectively with semaphorin receptors. MF
GO:0030216 keratinocyte differentiation The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte. BP
GO:0030217 T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a T cell. BP
GO:0030218 erythrocyte differentiation The process by which a myeloid precursor cell acquires specializes features of an erythrocyte. BP
GO:0030219 megakaryocyte differentiation The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte. BP
GO:0001922 B-1 B cell homeostasis The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. BP
GO:0001923 B-1 B cell differentiation The process whereby a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. BP
GO:0052009 disassembly by symbiont of host cell wall The chemical reactions and pathways performed by an organism resulting in the breakdown of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052008 disassembly by symbiont of host cellular component The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052001 Type IV pili-dependent localized adherence to host Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052000 Type IV pili-dependent aggregation The formation of bacterial aggregates in liquid culture dependent on the presence of Type IV pili. BP
GO:0052003 negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052002 metabolism by symbiont of substance in host The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052005 negative regulation by symbiont of host ethylene-mediated defense response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052004 negative regulation by symbiont of host salicylic acid-mediated defense response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052007 biosynthesis by symbiont of substance in host The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052006 catabolism by symbiont of substance in host The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0016119 carotene metabolic process The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids. BP
GO:0016118 carotenoid catabolic process The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. BP
GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. BP
GO:0016116 carotenoid metabolic process The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. BP
GO:0016115 terpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. BP
GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. BP
GO:0016113 polyterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units. BP
GO:0016112 polyterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units. BP
GO:0016111 polyterpenoid metabolic process The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units. BP
GO:0016110 tetraterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units. BP
GO:0016346 male meiotic chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis. BP
GO:0016344 meiotic chromosome movement towards spindle pole The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis. BP
GO:0016345 female meiotic chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis. BP
GO:0016342 catenin complex Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. CC
GO:0016340 calcium-dependent cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction. BP
GO:0031161 phosphatidylinositol catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. BP
GO:0031160 spore wall The specialized envelope lying outside the cell membrane of a spore. CC
GO:0031163 metallo-sulfur cluster assembly The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. BP
GO:0031162 sulfur incorporation into metallo-sulfur cluster The incorporation of exogenous sulfur into a metallo-sulfur cluster. BP
GO:0031165 integral to contractile vacuolar membrane Penetrating at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031164 contractile vacuolar membrane The lipid bilayer surrounding the contractile vacuole. CC
GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. BP
GO:0031166 integral to vacuolar membrane Penetrating at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031169 ferrichrome biosynthetic process The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. BP
GO:0031168 ferrichrome metabolic process The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. BP
GO:0043641 novobiocin metabolic process The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. BP
GO:0002347 response to tumor cell A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. BP
GO:0048784 pigment biosynthetic process during pigment granule maturation The chemical reactions and pathways resulting in the formation of a pigment, during the process by which a membrane bound organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. BP
GO:0002345 peripheral B cell receptor editing The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation. BP
GO:0002344 B cell affinity maturation The process by which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen. BP
GO:0043640 benzoate catabolic process via hydroxylation The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol. BP
GO:0048781 regulation of cyanophore differentiation Any process that modulates the frequency, rate or extent of cyanophore differentiation. BP
GO:0048780 positive regulation of erythrophore differentiation Any process that activates or increases the frequency, rate or extent of erythrophore differentiation. BP
GO:0048783 positive regulation of cyanophore differentiation Any process that activates or increases the frequency, rate or extent of cyanophore differentiation. BP
GO:0002340 central B cell selection Processes of B cell selection that occur in the bone marrow. BP
GO:0043643 tetracycline metabolic process The chemical reactions involving tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). BP
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. BP
GO:0009400 receptor signaling protein serine/threonine phosphatase activity NA MF
GO:0009403 toxin biosynthetic process The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. BP
GO:0009405 pathogenesis The specific processes that generate the ability of an organism to cause disease in another. BP
GO:0009404 toxin metabolic process The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. BP
GO:0009407 toxin catabolic process The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. BP
GO:0009409 response to cold A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. BP
GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. BP
GO:0046958 nonassociative learning A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment. BP
GO:0046959 habituation A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented. BP
GO:0046956 positive phototaxis The directed movement of a cell or organism towards a source of light. BP
GO:0046957 negative phototaxis The directed movement of a cell or organism away from a source of light. BP
GO:0046952 ketone body catabolic process The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA. BP
GO:0046950 ketone body metabolic process The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism. BP
GO:0046951 ketone body biosynthetic process The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA. BP
GO:0008469 histone-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N-methyl-arginine. MF
GO:0008460 dTDP-glucose 4,6-dehydratase activity Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O. MF
GO:0008462 endopeptidase Clp activity Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs). MF
GO:0008463 formylmethionine deformylase activity Catalysis of the reaction: N-formyl-L-methionine + H2O = formate + L-methionine. MF
GO:0008464 gamma-glutamyl hydrolase activity Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid. MF
GO:0008465 glycerate dehydrogenase activity Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. MF
GO:0008466 glycogenin glucosyltransferase activity Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. MF
GO:0008467 heparin-glucosamine 3-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparin-glucosamine = adenosine 3',5'-bisphosphate + heparin-glucosamine 3-O-sulfate. MF
GO:0047331 diphosphate-glycerol phosphotransferase activity Catalysis of the reaction: glycerol + pyrophosphate = phosphate + glycerol-3-phosphate. MF
GO:0042126 nitrate metabolic process The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. BP
GO:0047333 dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity Catalysis of the reaction: dihydrostreptomycin 6-phosphate + ATP = dihydrostreptomycin 3'-alpha-6-bisphosphate + ADP. MF
GO:0042124 1,3-beta-glucanosyltransferase activity Catalysis of the splitting and linkage of 1,3-beta-glucan molecules, resulting in 1,3-beta-glucan chain elongation. MF
GO:0042123 glucanosyltransferase activity Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation. MF
GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity Catalysis of the reaction: fructose-6-phosphate + pyrophosphate = phosphate + fructose-1,6-bisphosphate. MF
GO:0047337 dolichyl-diphosphate-polyphosphate phosphotransferase activity Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate. MF
GO:0047336 5-methyldeoxycytidine-5'-phosphate kinase activity Catalysis of the reaction: deoxy-5-methylcytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP. MF
GO:0047339 nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate. MF
GO:0047338 UTP:xylose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate. MF
GO:0042129 regulation of T cell proliferation Any process that modulates the frequency, rate or extent of T cell proliferation. BP
GO:0042128 nitrate assimilation The uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances. BP
GO:0003007 heart morphogenesis The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. BP
GO:0003006 reproductive developmental process A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. BP
GO:0003005 follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage The menstual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the scattered antral spaces stage of oogenesis. BP
GO:0003004 follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage The menstual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the antral spaces stage of oogenesis. BP
GO:0003003 follicular fluid formation in ovarian follicle antrum during fused antrum stage The menstual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the fused antrum stage of oogenesis. BP
GO:0003002 regionalization The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. BP
GO:0003001 generation of a signal involved in cell-cell signaling The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal. BP
GO:0045793 positive regulation of cell size Any process that increases cell size. BP
GO:0045792 negative regulation of cell size Any process that reduces cell size. BP
GO:0045795 positive regulation of cell volume Any process that increases cell volume. BP
GO:0045794 negative regulation of cell volume Any process that decreases cell volume. BP
GO:0045797 positive regulation of cholesterol absorption Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine. BP
GO:0045796 negative regulation of cholesterol absorption Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine. BP
GO:0045799 positive regulation of chromatin assembly or disassembly Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly. BP
GO:0045798 negative regulation of chromatin assembly or disassembly Any process that stops, prevents or reduces the frequency, rate or extent of chromatin assembly or disassembly. BP
GO:0030979 alpha-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of alpha-glucans. BP
GO:0030978 alpha-glucan metabolic process The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. BP
GO:0030975 thiamin binding Interacting selectively with thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. MF
GO:0030974 thiamin pyrophosphate transport The directed movement of thiamin pyrophosphate into, out of, within or between cells. BP
GO:0030977 taurine binding Interacting selectively with taurine. MF
GO:0030976 thiamin pyrophosphate binding Interacting selectively with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. MF
GO:0030971 receptor tyrosine kinase binding Interacting selectively with a receptor that possesses protein tyrosine kinase activity. MF
GO:0030970 retrograde protein transport, ER to cytosol The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. BP
GO:0030973 molybdate ion binding Interacting selectively with molybdate (MoO4 2-) ions. MF
GO:0030972 cleavage of cytosolic proteins during apoptosis The proteolytic degradation of proteins in the cytosol during apoptosis. BP
GO:0050959 echolocation Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning. BP
GO:0050958 magnetoreception The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light. BP
GO:0050955 thermoception The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). BP
GO:0050954 sensory perception of mechanical stimulus The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0050957 equilibrioception The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion. BP
GO:0050956 electroception The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. BP
GO:0050951 sensory perception of temperature stimulus The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0050950 positive regulation of late stripe melanocyte differentiation Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation. BP
GO:0050953 sensory perception of light stimulus The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0050952 sensory perception of electrical stimulus The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0002754 intracellular vesicle pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. BP
GO:0002755 MyD88-dependent toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. BP
GO:0002756 MyD88-independent toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. BP
GO:0002757 immune response-activating signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response. BP
GO:0002750 antigen processing and presentation following macropinocytosis Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis. BP
GO:0002751 antigen processing and presentation following receptor mediated endocytosis Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis. BP
GO:0002752 cell surface pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. BP
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a cytoplasmic pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. BP
GO:0002758 innate immune response-activating signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response. BP
GO:0002759 regulation of antimicrobial humoral response Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response. BP
GO:0044446 intracellular organelle part A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. CC
GO:0044447 axoneme part Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements. CC
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. CC
GO:0044445 cytosolic part Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. CC
GO:0044442 flagellar part (sensu Eukaryota) Any constituent part of a flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0044443 fimbrial part Any constituent part of a fimbrium, a proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter. CC
GO:0044440 endosomal part Any constituent part of an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation. CC
GO:0044441 cilium part Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. CC
GO:0044448 cell cortex part Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. CC
GO:0044449 contractile fiber part Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. CC
GO:0046178 D-gluconate biosynthetic process The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. BP
GO:0046179 D-dehydro-D-gluconate biosynthetic process The chemical reactions and pathways resulting in the formation of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose. BP
GO:0046170 methanol catabolic process The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. BP
GO:0046171 octanol biosynthetic process The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH. BP
GO:0046172 octanol catabolic process The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH. BP
GO:0046173 polyol biosynthetic process The chemical reactions and pathways resulting in the formation of a polyol, any polyhydric alcohol. BP
GO:0046174 polyol catabolic process The chemical reactions and pathways resulting in the breakdown of a polyol, any polyhydric alcohol. BP
GO:0046175 aldonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. BP
GO:0046176 aldonic acid catabolic process The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. BP
GO:0046177 D-gluconate catabolic process The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. BP
GO:0048208 COPII coating of Golgi vesicle The addition of COPII proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. BP
GO:0048209 regulation of vesicle targeting, to, from or within Golgi Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. BP
GO:0048200 Golgi transport vesicle coating The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles. BP
GO:0048201 vesicle targeting, plasma membrane to endosome The process by which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. BP
GO:0048202 clathrin coating of Golgi vesicle The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. BP
GO:0048203 vesicle targeting, trans-Golgi to endosome The process by which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome. BP
GO:0048204 vesicle targeting, inter-Golgi cisterna The process by which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another. BP
GO:0048205 COPI coating of Golgi vesicle The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. BP
GO:0048206 vesicle targeting, cis-Golgi to rough ER The process by which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER. BP
GO:0048207 vesicle targeting, rough ER to cis-Golgi The process by which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi. BP
GO:0042462 eye photoreceptor cell development Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. BP
GO:0042463 non-eye photoreceptor cell development Development of non-eye photoreceptors, sensory cells that react to the presence of light, found outside of the eye. BP
GO:0042461 photoreceptor cell development Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. BP
GO:0042466 chemokinesis A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis). BP
GO:0042467 orthokinesis The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased. BP
GO:0042464 dosage compensation, by hypoactivation of X chromosome Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. BP
GO:0042465 kinesis The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus. BP
GO:0004345 glucose-6-phosphate 1-dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. MF
GO:0004344 glucose dehydrogenase (acceptor) activity Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor. MF
GO:0042468 klinokinesis The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered. BP
GO:0004346 glucose-6-phosphatase activity Catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate. MF
GO:0004341 gluconolactonase activity Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. MF
GO:0004340 glucokinase activity Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate. MF
GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate. MF
GO:0004342 glucosamine-6-phosphate deaminase activity Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3. MF
GO:0008873 gluconate 2-dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+. MF
GO:0006856 eye pigment precursor transport The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of, within or between cells. BP
GO:0008871 gentamicin 2''-nucleotidyltransferase activity Catalysis of the reaction: nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin. MF
GO:0008870 galactoside O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside. MF
GO:0008877 glucose-1-phosphatase activity Catalysis of the reaction: D-glucose 1-phosphate + H2O = D-glucose + phosphate. MF
GO:0008876 quinoprotein glucose dehydrogenase activity Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol. MF
GO:0008875 gluconate dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+. MF
GO:0008874 gluconate 5-dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+. MF
GO:0008879 glucose-1-phosphate thymidylyltransferase activity Catalysis of the reaction: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose. MF
GO:0008878 glucose-1-phosphate adenylyltransferase activity Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. MF
GO:0006859 extracellular carbohydrate transport The directed extracellular movement of carbohydrates. BP
GO:0006858 extracellular transport The transport of substances that occurs outside cells. BP
GO:0018469 myrtenal dehydrogenase activity Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid. MF
GO:0018468 alcohol dehydrogenase (acceptor) activity Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor. MF
GO:0018465 vanillyl-alcohol oxidase activity Catalysis of the reaction: vanillyl alcohol + O2 = vanillin + H2O2. MF
GO:0018464 3-hydroxypimeloyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxypimeloyl-CoA + NAD+ = 3-oxopimeloyl-CoA + NADH + H+. MF
GO:0018467 formaldehyde dehydrogenase activity Catalysis of the reaction: formaldehyde + NAD+ + H2O = formate + NADH + H+. Unlike EC:1.2.1.1 formaldehyde dehydrogenase (glutathione), this enzyme does not need reduced glutathione. MF
GO:0018466 limonene-1,2-diol dehydrogenase activity Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene. MF
GO:0018461 fluoren-9-ol dehydrogenase activity Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+. MF
GO:0018460 cyclohexanol dehydrogenase activity Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+. MF
GO:0018463 6-hydroxyhexanoate dehydrogenase activity Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+. MF
GO:0018462 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + NADH + H+. MF
GO:0019332 aerobic respiration, using nitrite as electron donor The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species. BP
GO:0019333 denitrification pathway The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen. BP
GO:0019330 aldoxime metabolic process The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH. BP
GO:0019331 anaerobic respiration, using ammonium as electron donor The oxidation of ammonium (NH4) to nitrogen (N2), using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2. BP
GO:0019336 phenol catabolic process The chemical reactions and pathways resulting in the breakdown of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. BP
GO:0019337 tetrachloroethylene catabolic process The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines. BP
GO:0019334 p-cymene catabolic process The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants. BP
GO:0019335 3-methylquinoline catabolic process The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. BP
GO:0019338 pentachlorophenol catabolic process The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms. BP
GO:0019339 parathion catabolic process The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition. BP
GO:0050182 phosphate butyryltransferase activity Catalysis of the reaction: butanoyl-CoA + phosphate = CoA + butanoylphosphate. MF
GO:0050183 phosphatidylcholine 12-monooxygenase activity Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + NAD+ + H2O. MF
GO:0050180 phloretin hydrolase activity Catalysis of the reaction: phloretin + H2O = phloretate + phloroglucinol. MF
GO:0050181 phorbol-diester hydrolase activity Catalysis of the reaction: phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate. MF
GO:0050186 phosphoadenylylsulfatase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + SO4(2-) (sulfate). MF
GO:0050187 phosphoamidase activity Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate. MF
GO:0050184 phosphatidylcholine desaturase activity Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+ = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH. MF
GO:0050185 phosphatidylinositol deacylase activity Catalysis of the reaction: 1-phosphatidyl-D-myo-inositol + H2O = 1-acylglycerophosphoinositol + a carboxylate. MF
GO:0050188 phosphoenolpyruvate mutase activity Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate. MF
GO:0050189 phosphoenolpyruvate phosphatase activity Catalysis of the reaction: phosphoenolpyruvate + H2O = pyruvate + phosphate. MF
GO:0052541 cell wall cellulose metabolism The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. BP
GO:0018500 trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene. MF
GO:0018501 cis-chlorobenzene dihydrodiol dehydrogenase activity NA MF
GO:0007069 negative regulation of transcription from RNA polymerase I promoter, mitotic Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis. BP
GO:0007068 negative regulation of transcription, mitotic Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis. BP
GO:0007065 male meiosis sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male. BP
GO:0007064 mitotic sister chromatid cohesion The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during mitosis. This cohesion cycle is critical for high fidelity chromosome transmission. BP
GO:0007067 mitosis Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. BP
GO:0007066 female meiosis sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female. BP
GO:0007060 male meiosis chromosome segregation The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male. BP
GO:0007063 regulation of sister chromatid cohesion Any process that modulates the frequency, rate or extent of sister chromatid cohesion. BP
GO:0007062 sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome. BP
GO:0018504 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+. MF
GO:0052547 regulation of peptidase activity Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of peptide linkages within nucleic acids. BP
GO:0018508 cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+. MF
GO:0043562 cellular response to nitrogen levels A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. BP
GO:0016558 protein import into peroxisome matrix The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. BP
GO:0045378 regulation of interleukin-17 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17. BP
GO:0008591 regulation of frizzled-2 signaling pathway Any process that modulates the frequency, rate or extent of the frizzled-2 signaling pathway. BP
GO:0005126 hematopoietin/interferon-class (D200-domain) cytokine receptor binding NA MF
GO:0005127 ciliary neurotrophic factor receptor binding Interacting selectively with the ciliary neurotrophic factor receptor. MF
GO:0016553 base conversion or substitution editing Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s). BP
GO:0005124 scavenger receptor binding Interacting selectively with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. MF
GO:0016552 cotranscriptional insertion or deletion editing The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription. BP
GO:0005125 cytokine activity Functions to control the survival, growth, differentiation and effector function of tissues and cells. MF
GO:0052128 positive energy taxis The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. BP
GO:0052129 negative energy taxis The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. BP
GO:0052126 movement in host environment The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052127 movement on or near host The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052124 energy taxis within host The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052125 energy taxis on or near host The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052122 negative aerotaxis in host environment The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052123 negative chemotaxis in host environment The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052120 positive aerotaxis in host environment The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052121 positive chemotaxis in host environment The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0045370 negative regulation of interleukin-14 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14. BP
GO:0005120 thickveins binding Interacting selectively with the thickveins (tkv) protein, a type I transforming growth factor beta receptor. MF
GO:0005121 Toll binding Interacting selectively with the Toll protein, a transmembrane receptor. MF
GO:0045376 negative regulation of interleukin-16 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16. BP
GO:0005128 erythropoietin receptor binding Interacting selectively with the erythropoietin receptor. MF
GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding Interacting selectively with the granulocyte macrophage colony-stimulating factor receptor. MF
GO:0006084 acetyl-CoA metabolic process The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. BP
GO:0006085 acetyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. BP
GO:0006086 acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from other compounds, including pyruvate. BP
GO:0006087 pyruvate dehydrogenase bypass NA BP
GO:0006080 mannan metabolic process The chemical reactions and pathways involving mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. Mannans also occur in ferns, high plants, algae and some yeasts where they may function as the main structural component of the cell wall. BP
GO:0006081 aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O. BP
GO:0006082 organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. BP
GO:0006083 acetate metabolic process The chemical reactions and pathways involving acetate, the anion of acetic acid. BP
GO:0006089 lactate metabolic process The chemical reactions and pathways involving lactate, the anion of lactic acid. BP
GO:0010238 response to proline A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus. BP
GO:0010239 chloroplast mRNA processing Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs. BP
GO:0010230 alternative respiration Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa. BP
GO:0010231 maintenance of seed dormancy The processes by which a dormant state is maintained in a seed. BP
GO:0010232 vascular transport The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane. BP
GO:0010233 phloem transport The directed movement of substances, into, out of or within a cell, either in a phloem tissue or in the phloem membrane. BP
GO:0010234 tapetal cell fate specification The process by which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0010235 guard mother cell cytokinesis The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells. BP
GO:0010236 plastoquinone biosynthetic process The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast. BP
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. CC
GO:0005577 fibrinogen complex A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. CC
GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. CC
GO:0005579 membrane attack complex A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow. CC
GO:0005578 extracellular matrix (sensu Metazoa) A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). CC
GO:0042144 vacuole fusion, non-autophagic The fusion of two vacuole membranes to form a single vacuole. BP
GO:0000718 nucleotide-excision repair, DNA damage removal The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage. BP
GO:0000719 photoreactive repair The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines. BP
GO:0000712 resolution of meiotic joint molecules as recombinants The cleavage and rejoining of Holliday junctions to produce two intact molecules in which genetic material has been exchanged. BP
GO:0000713 meiotic heteroduplex formation During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. BP
GO:0000710 meiotic mismatch repair A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. BP
GO:0000711 meiotic DNA repair synthesis During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template. BP
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. BP
GO:0000717 nucleotide-excision repair, DNA duplex unwinding The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. BP
GO:0000714 meiotic strand displacement The cell cycle process whereby the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis. BP
GO:0000715 nucleotide-excision repair, DNA damage recognition The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. BP
GO:0004629 phospholipase C activity Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. MF
GO:0004622 lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. MF
GO:0004623 phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. MF
GO:0004620 phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid. MF
GO:0004621 glycosylphosphatidylinositol phospholipase D activity Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. MF
GO:0018148 RNA-protein covalent cross-linking via peptidyl-tyrosine The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine. BP
GO:0018149 peptide cross-linking The formation of a covalent cross-link between or within protein chains. BP
GO:0018142 DNA-protein covalent cross-linking The formation of a covalent cross-link between DNA and a protein. BP
GO:0018143 nucleic acid-protein covalent cross-linking The formation of a covalent cross-link between a nucleic acid and a protein. BP
GO:0018140 peptide cross-linking via L-cysteine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018141 peptide cross-linking via L-lysine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018146 keratan sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. BP
GO:0018147 molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). BP
GO:0018144 RNA-protein covalent cross-linking The formation of a covalent cross-link between RNA and a protein. BP
GO:0018145 DNA-protein covalent cross-linking via peptidyl-serine The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine. BP
GO:0021898 commitment of multipotent stem cells to the neuronal lineage in the forebrain The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain. BP
GO:0021899 fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. BP
GO:0021894 cerebral cortex GABAergic interneuron development The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell. BP
GO:0021895 cerebral cortex neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. BP
GO:0021896 forebrain astrocyte differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. BP
GO:0021897 forebrain astrocyte development The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. BP
GO:0021890 olfactory bulb interneuron fate commitment The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb. BP
GO:0021891 olfactory bulb interneuron development The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. BP
GO:0021892 cerebral cortex GABAergic interneuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. BP
GO:0021893 cerebral cortex GABAergic interneuron fate commitment The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex. BP
GO:0016098 monoterpenoid metabolic process The chemical reactions and pathways involving monoterpenoid compounds, terpenoids with two isoprene units. BP
GO:0016099 monoterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids with two isoprene units. BP
GO:0016092 prenol catabolic process The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. BP
GO:0016093 polyprenol metabolic process The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. BP
GO:0016090 prenol metabolic process The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. BP
GO:0016091 prenol biosynthetic process The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail. BP
GO:0016096 polyisoprenoid metabolic process The chemical reactions and pathways involving polyisoprenoids, acyclic polymers containing a large number of isoprene subunits, usually unsaturated. BP
GO:0016097 polyisoprenoid catabolic process The chemical reactions and pathways resulting in the breakdown of polyisoprenoids, acyclic polymers containing a large number of isoprene subunits, usually unsaturated. BP
GO:0016094 polyprenol biosynthetic process The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. BP
GO:0016095 polyprenol catabolic process The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans. BP
GO:0021766 hippocampus development The progression of the hippocampus over time from its initial formation until its mature state. BP
GO:0021767 mammilary body development The progression of the mammilary body over time from its initial formation until its mature state. The mammilary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei. BP
GO:0021764 amygdala development The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure. BP
GO:0021765 cingulate gyrus development The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum. BP
GO:0021762 substantia nigra development The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). BP
GO:0021763 subthalamic nucleus development The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function. BP
GO:0021761 limbic system development The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. BP
GO:0021768 nucleus accumbens development The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia. BP
GO:0021769 orbitofrontal cortex development The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe. BP
GO:0015679 plasma membrane copper ion transport The directed movement of copper ions across the plasma membrane. BP
GO:0015678 high affinity copper ion transport NA BP
GO:0015677 copper ion import The directed movement of copper ions into a cell or organelle. BP
GO:0015676 vanadium ion transport The directed movement of vanadium (V) ions into, out of, within or between cells. BP
GO:0015675 nickel ion transport The directed movement of nickel (Ni) ions into, out of, within or between cells. BP
GO:0015674 di-, tri-valent inorganic cation transport The directed movement of inorganic cations with a valency of two or three into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. BP
GO:0015673 silver ion transport The directed movement of silver (Ag) ions into, out of, within or between cells. BP
GO:0015672 monovalent inorganic cation transport The directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. BP
GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells. BP
GO:0015670 carbon dioxide transport The directed movement of carbon dioxide (CO2) into, out of, within or between cells. BP
GO:0016328 lateral plasma membrane The membranes on the sides of epithelial cells which lie at the interface of adjacent cells. CC
GO:0046378 enterobacterial common antigen metabolic process The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. BP
GO:0046379 extracellular polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides used in extracellular structures. BP
GO:0016324 apical plasma membrane Part of the plasma membrane at the apical end of the cell. CC
GO:0046377 colanic acid metabolic process The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues. BP
GO:0046374 teichoic acid metabolic process The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. BP
GO:0016327 apicolateral plasma membrane The apical end of the lateral plasma membrane of epithelial cells. CC
GO:0016320 endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum. BP
GO:0016321 female meiosis chromosome segregation The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. BP
GO:0046370 fructose biosynthetic process The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose. BP
GO:0046371 dTDP-mannose metabolic process The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate. BP
GO:0030401 transcription antiterminator activity Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed. MF
GO:0030403 collagenase 4 activity NA MF
GO:0030402 matrilysin-2 activity NA MF
GO:0030405 matrix metalloproteinase 19 activity NA MF
GO:0030404 collagenase 3 activity NA MF
GO:0030407 formimidoyltransferase activity Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid. MF
GO:0030406 matrix metalloproteinase 25 activity NA MF
GO:0030409 glutamate formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. MF
GO:0030408 glycine formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = tetrahydrofolate + N-formimidoylglycine. MF
GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity Catalysis of the reaction: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] + ATP = [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate + ADP. MF
GO:0047964 glyoxylate reductase activity Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH. MF
GO:0047965 glycoprotein O-fatty-acyltransferase activity Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein. MF
GO:0047966 glycosulfatase activity Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + SO4(2-) (sulfate). MF
GO:0047967 glycyrrhizinate beta-glucuronidase activity Catalysis of the reaction: H2O + glycyrrhizinate = 1,2-beta-D-glucuronosyl-D-glucuronate + glycyrrhetinate. MF
GO:0047960 glycine dehydrogenase activity Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH. MF
GO:0047961 glycine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. MF
GO:0047962 glycine N-benzoyltransferase activity Catalysis of the reaction: benzoyl-CoA + glycine = CoA + N-benzoylglycine. MF
GO:0047963 glycine N-choloyltransferase activity Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate. MF
GO:0047968 glyoxylate dehydrogenase (acylating) activity Catalysis of the reaction: glyoxylate + CoA + NADP+ = oxalyl-CoA + NADPH. MF
GO:0047969 glyoxylate oxidase activity Catalysis of the reaction: glyoxylate + H2O + O2 = oxalate + H2O2. MF
GO:0047041 (S)-carnitine 3-dehydrogenase activity Catalysis of the reaction: NAD+ + L-carnitine = NADH + H+ + 3-dehydrocarnitine. MF
GO:0031468 nuclear envelope reassembly The reformation of the nuclear envelope fllowing its breakdown in the context of a normal process. BP
GO:0031469 polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. CC
GO:0031460 glycine betaine transport The directed movement of glycine betaine, N-trimethylglycine, into, out of, within or between cells. BP
GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. CC
GO:0031462 Cul2-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. CC
GO:0031463 Cul3-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. CC
GO:0031464 Cul4A-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. CC
GO:0031465 Cul4B-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits. CC
GO:0031466 Cul5-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. CC
GO:0031467 Cul7-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein. CC
GO:0044248 cellular catabolic process The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. BP
GO:0009659 leucoplast organization and biogenesis The assembly and arrangement of a leucoplast. BP
GO:0047325 inositol tetrakisphosphate 1-kinase activity Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. MF
GO:0044240 organismal lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, occurring at the tissue, organ, or organismal level of a multicellular organism. BP
GO:0044241 lipid digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. BP
GO:0044242 cellular lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. BP
GO:0009676 low affinity sulfate:hydrogen symporter activity Catalysis of the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). Transporter that mediates the transport of sulfate between cellular or subcellular compartments with a low affinity for hydrogen and sulfate. MF
GO:0009677 double fertilization (sensu Gnetophyta) Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. As in, but not restricted to, the taxon Gnetophyta (Gnetophyta, ncbi_taxonomy_id:58022). BP
GO:0009674 potassium:sodium symporter activity Catalysis of the reaction: K+(out) + Na+(out) = K+(in) + Na+(in). MF
GO:0009653 anatomical structure morphogenesis The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0009672 auxin:hydrogen symporter activity Catalysis of the reaction: auxin(out) + H+(out) = auxin(in) + H+(in). MF
GO:0009673 low affinity phosphate transporter activity Transporter that catalyzes phosphate transport with a low affinity for phosphate. MF
GO:0044260 cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, as carried out by individual cells. BP
GO:0009671 nitrate:hydrogen symporter activity Catalysis of the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in). MF
GO:0044244 organismal polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, occurring at the tissue, organ, or organismal level of a multicellular organism. BP
GO:0044268 organismal protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level. BP
GO:0009679 hexose:hydrogen symporter activity Catalysis of the reaction: hexose(out) + H+(out) = hexose(in) + H+(in). MF
GO:0044246 regulation of organismal metabolic process Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. BP
GO:0044247 cellular polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. BP
GO:0047208 o-dihydroxycoumarin 7-O-glucosyltransferase activity Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + UDP. MF
GO:0010166 wax metabolic process The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids. BP
GO:0010167 response to nitrate A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus. BP
GO:0047207 1,2-beta-fructan 1F-fructosyltransferase activity Catalysis of the reaction: (1,2-beta-D-fructosyl)(n) + (1,2-beta-D-fructosyl)(m) = (1,2-beta-D-fructosyl)(n+1) + (1,2-beta-D-fructosyl)(m-1). MF
GO:0047206 UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA. MF
GO:0010168 ER body A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species. CC
GO:0010169 myrosinase complex A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds. CC
GO:0045618 positive regulation of keratinocyte differentiation Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. BP
GO:0045619 regulation of lymphocyte differentiation Any process that modulates the frequency, rate or extent of lymphocyte differentiation. BP
GO:0045614 negative regulation of plasmatocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of plasmatocyte differentiation. BP
GO:0045615 positive regulation of plasmatocyte differentiation Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation. BP
GO:0045616 regulation of keratinocyte differentiation Any process that modulates the frequency, rate or extent of keratinocyte differentiation. BP
GO:0045617 negative regulation of keratinocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte differentiation. BP
GO:0045610 regulation of hemocyte differentiation Any process that modulates the frequency, rate or extent of hemocyte differentiation. BP
GO:0045611 negative regulation of hemocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of hemocyte differentiation. BP
GO:0045612 positive regulation of hemocyte differentiation Any process that activates or increases the frequency, rate or extent of hemocyte differentiation. BP
GO:0045613 regulation of plasmatocyte differentiation Any process that modulates the frequency, rate or extent of plasmatocyte differentiation. BP
GO:0047106 4-hydroxyphenylacetaldehyde dehydrogenase activity Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate. MF
GO:0047107 gamma-guanidinobutyraldehyde dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + 4-guanidinobutanal = NADH + 4-guanidinobutanoate. MF
GO:0047104 hexadecanal dehydrogenase (acylating) activity Catalysis of the reaction: NAD+ + CoA + palmitaldehyde = NADH + palmityl-CoA. MF
GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate. MF
GO:0047102 aminomuconate-semialdehyde dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate. MF
GO:0047103 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate. MF
GO:0047100 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate. MF
GO:0047101 2-oxoisovalerate dehydrogenase (acylating) activity Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA. MF
GO:0047108 (R)-3-hydroxyacid-ester dehydrogenase activity Catalysis of the reaction: NADP+ + ethyl (R)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate. MF
GO:0047109 (S)-3-hydroxyacid-ester dehydrogenase activity Catalysis of the reaction: NADP+ + ethyl (S)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate. MF
GO:0031873 type 2 proteinase activated receptor binding Interacting selectively with a type 2 proteinase activated receptor. MF
GO:0031872 type 1 proteinase activated receptor binding Interacting selectively with a type 1 proteinase activated receptor. MF
GO:0031871 proteinase activated receptor binding Interacting selectively with a proteinase activated receptor. MF
GO:0031870 thromboxane A2 receptor binding Interacting selectively with a thromboxane A2 receptor. MF
GO:0031877 somatostatin receptor binding Interacting selectively with a somatostatin receptor. MF
GO:0031876 secretin receptor binding Interacting selectively with a secretin receptor. MF
GO:0031875 type 4 proteinase activated receptor binding Interacting selectively with a type 4 proteinase activated receptor. MF
GO:0031874 type 3 proteinase activated receptor binding Interacting selectively with a type 3 proteinase activated receptor. MF
GO:0031879 type 2 somatostatin receptor binding Interacting selectively with a type 2 somatostatin receptor. MF
GO:0031878 type 1 somatostatin receptor binding Interacting selectively with a type 1 somatostatin receptor. MF
GO:0048909 anterior lateral line nerve development The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. BP
GO:0048908 anterior lateral line ganglion neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion. BP
GO:0048903 anterior lateral line neuromast hair cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. BP
GO:0048902 anterior lateral line neuromast deposition The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line. BP
GO:0048901 anterior lateral line neuromast development The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. BP
GO:0005770 late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. CC
GO:0048907 anterior lateral line ganglion development The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear. BP
GO:0048906 anterior lateral line neuromast support cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. BP
GO:0048905 anterior lateral line neuromast mantle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. BP
GO:0048904 anterior lateral line neuromast cupula development The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. BP
GO:0007608 sensory perception of smell The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. BP
GO:0007605 sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. BP
GO:0007604 phototransduction, UV The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. BP
GO:0007606 sensory perception of chemical stimulus The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. BP
GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0007603 phototransduction, visible light The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. BP
GO:0007602 phototransduction The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. BP
GO:0002279 mast cell activation during immune response The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. BP
GO:0002278 eosinophil activation during immune response The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002277 myeloid dendritic cell activation during immune response The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002276 basophil activation during immune response A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. BP
GO:0002275 myeloid cell activation during immune response A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. BP
GO:0002274 myeloid leukocyte activation A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. BP
GO:0002273 plasmacytoid dendritic cell differentiation The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell. BP
GO:0002272 plasmacytoid dendritic cell differentiation during immune response The process whereby an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell during an immune response. BP
GO:0002271 plasmacytoid dendritic cell activation during immune response A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. BP
GO:0002270 plasmacytoid dendritic cell activation A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. BP
GO:0018788 atrazine chlorohydrolase activity Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride. MF
GO:0018789 cyclamate sulfohydrolase activity Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + SO4(2-) (sulfate). MF
GO:0018780 dichloroacetate halidohydrolase activity Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate. MF
GO:0018781 S-triazine hydrolase activity NA MF
GO:0018782 cis-chloroacrylic acid dehalogenase activity Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde. MF
GO:0018783 deisopropyldeethylatrazine hydrolase activity NA MF
GO:0018784 (S)-2-haloacid dehalogenase activity Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. MF
GO:0018785 haloacetate dehalogenase activity Catalysis of the reaction: haloacetate + H2O = glycolate + halide. MF
GO:0018786 haloalkane dehalogenase activity Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide. MF
GO:0018787 4-chlorobenzoyl-CoA dehalogenase activity Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride. MF
GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. BP
GO:0048018 receptor agonist activity Interacts with receptors such that the proportion of receptors in the active form is increased. MF
GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). BP
GO:0006956 complement activation Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. BP
GO:0006957 complement activation, alternative pathway Processes involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. BP
GO:0006954 inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. BP
GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. BP
GO:0048011 nerve growth factor receptor signaling pathway The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands. BP
GO:0048010 vascular endothelial growth factor receptor signaling pathway The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands. BP
GO:0048013 ephrin receptor signaling pathway The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. BP
GO:0048012 hepatocyte growth factor receptor signaling pathway The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands. BP
GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. BP
GO:0048014 Tie receptor signaling pathway The series of molecular signals generated as a consequence of a Tie receptor binding to one of its physiological ligands (angiopoietins). BP
GO:0048017 inositol lipid-mediated signaling A series of molecular signals in which a cell uses an inositol lipid to convert an extracellular signal into a response. BP
GO:0048016 inositol phosphate-mediated signaling A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert an extracellular signal into a response. BP
GO:0019787 small conjugating protein ligase activity Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. MF
GO:0019786 APG8-specific protease activity Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier. MF
GO:0019785 ISG15-specific protease activity Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates. MF
GO:0019784 NEDD8-specific protease activity Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates. MF
GO:0019783 small conjugating protein-specific protease activity Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups. MF
GO:0019782 ISG15 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0019781 NEDD8 activating enzyme activity Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. MF
GO:0019780 FAT10 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0019789 SUMO ligase activity Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function. MF
GO:0019788 NEDD8 ligase activity Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue. MF
GO:0021564 vagus nerve development The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. BP
GO:0021565 accessory nerve development The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. BP
GO:0021566 hypoglossal nerve development The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. BP
GO:0021567 rhombomere 1 development The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021560 abducens nerve development The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. BP
GO:0021561 facial nerve development The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. BP
GO:0021562 vestibulocochlear nerve development The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. BP
GO:0021563 glossopharyngeal nerve development Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. BP
GO:0021568 rhombomere 2 development The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021569 rhombomere 3 development The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0050029 L-lysine oxidase activity Catalysis of the reaction: L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2. MF
GO:0050028 L-lysine-lactamase activity Catalysis of the reaction: L-lysine 1,6-lactam + H2O = L-lysine. MF
GO:0050021 L-arabinonolactonase activity Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate. MF
GO:0050020 L-arabinonate dehydratase activity Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O. MF
GO:0050023 L-fuconate dehydratase activity Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O. MF
GO:0050022 L-arabinose 1-dehydrogenase activity Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH. MF
GO:0050025 L-glutamate oxidase activity Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2. MF
GO:0050024 L-galactonolactone oxidase activity Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2. MF
GO:0050027 L-idonate 2-dehydrogenase activity Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH. MF
GO:0050026 L-glycol dehydrogenase activity Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+. MF
GO:0007388 posterior compartment specification The process involved in the specification of cell identity in the posterior compartments of the segmented embryo. BP
GO:0007389 pattern specification process The developmental processes that result in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. BP
GO:0007380 specification of segmental identity, head The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0007381 specification of segmental identity, labial segment The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0007382 specification of segmental identity, maxillary segment The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0007383 specification of segmental identity, antennal segment The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0007384 specification of segmental identity, thorax The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0007385 specification of segmental identity, abdomen The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0007386 compartment specification The regionalization process by which embryonic segments are divided into compartments that will result in differences in cell differentiation. BP
GO:0007387 anterior compartment specification The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo. BP
GO:0051648 vesicle localization The processes by which a vesicle or vesicles are transported to, and/or maintained in, a specific location. BP
GO:0051649 establishment of cellular localization The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. BP
GO:0051646 mitochondrion localization The processes by which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. BP
GO:0051647 nucleus localization The processes by which the nucleus is transported to, and/or maintained in, a specific location within the cell. BP
GO:0051644 plastid localization The processes by which a plastid is transported to, and/or maintained in, a specific location within the cell. BP
GO:0051645 Golgi localization The processes by which the Golgi is transported to, and/or maintained in, a specific location within the cell. BP
GO:0051642 centrosome localization The processes by which a centrosome is transported to, and/or maintained in, a specific location within the cell. BP
GO:0051643 ER localization The processes by which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell. BP
GO:0051640 organelle localization The processes by which an organelle is transported to, and/or maintained in, a specific location. BP
GO:0051641 cellular localization The processes by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell. BP
GO:0006163 purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0006161 deoxyguanosine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose. BP
GO:0006160 guanosine phosphorolysis NA BP
GO:0006167 AMP biosynthetic process The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. BP
GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. BP
GO:0006165 nucleoside diphosphate phosphorylation The process of introducing a phosphoric group into a nucleoside diphosphate to produce a nucleoside triphosphate. BP
GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0006169 adenosine salvage Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis. BP
GO:0006168 adenine salvage Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. BP
GO:0015198 oligopeptide transporter activity Enables the directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. MF
GO:0015199 betaine transporter activity Enables the directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of, within or between cells. MF
GO:0015196 L-tryptophan transporter activity Enables the directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of, within or between cells. MF
GO:0015197 peptide transporter activity Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. MF
GO:0015194 L-serine transporter activity Enables the directed movement of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells. MF
GO:0015195 L-threonine transporter activity Enables the directed movement of L-threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of, within or between cells. MF
GO:0015192 L-phenylalanine transporter activity Enables the directed movement of L-phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of, within or between cells. MF
GO:0015193 L-proline transporter activity Enables the directed movement of L-proline, pyrrolidine-2-carboxylic acid, into, out of, within or between cells. MF
GO:0015190 L-leucine transporter activity Enables the directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of, within or between cells. MF
GO:0015191 L-methionine transporter activity Enables the directed movement of L-methionine, 2-amino-4-(methylthio)butanoic acid, into, out of, within or between cells. MF
GO:0015738 glucuronate transport The directed movement of glucuronate into, out of, within or between cells. BP
GO:0015739 sialic acid transport The directed movement of sialic acid into, out of, within or between cells. BP
GO:0015732 prostaglandin transport The directed movement of prostaglandins into, out of, within or between cells. BP
GO:0015733 shikimate transport The directed movement of shikimate into, out of, within or between cells. BP
GO:0015730 propionate transport The directed movement of propionate into, out of, within or between cells. BP
GO:0015731 3-hydroxyphenyl propanoate transport The directed movement of 3-hydroxyphenyl propanoate into, out of, within or between cells. BP
GO:0015736 hexuronate transport The directed movement of hexuronate into, out of, within or between cells. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. BP
GO:0015737 galacturonate transport The directed movement of galacturonate into, out of, within or between cells. BP
GO:0015734 taurine transport The directed movement of taurine into, out of, within or between cells. BP
GO:0015735 uronic acid transport The directed movement of uronic acid into, out of, within or between cells. BP
GO:0047744 chloridazon-catechol dioxygenase activity Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone. MF
GO:0047745 chlorogenate hydrolase activity Catalysis of the reaction: chlorogenate + H2O = caffeate + quinate. MF
GO:0047746 chlorophyllase activity Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide. MF
GO:0047747 cholate-CoA ligase activity Catalysis of the reaction: ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA. MF
GO:0047740 cephalosporin-C transaminase activity Catalysis of the reaction: cephalosporin C + pyruvate = 7-(5-carboxyl-5-oxopentanyl)-aminocephalosporinate + L-alanine. MF
GO:0047741 cetraxate benzylesterase activity Catalysis of the reaction: cetraxate benzyl ester + H2O = cetraxate + benzyl alcohol. MF
GO:0047742 chenodeoxycholoyltaurine hydrolase activity Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine. MF
GO:0047743 chlordecone reductase activity Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + NADPH. MF
GO:0047748 cholestanetetraol 26-dehydrogenase activity Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH. MF
GO:0047749 cholestanetriol 26-monooxygenase activity Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O. MF
GO:0043454 alkyne catabolic process The chemical reactions and pathways resulting in the breakdown of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. BP
GO:0043455 regulation of secondary metabolic process Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. BP
GO:0043456 regulation of pentose-phosphate shunt Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process by which glucose is oxidized, coupled to NADPH synthesis. BP
GO:0043457 regulation of cellular respiration Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. BP
GO:0043450 alkene biosynthetic process The chemical reactions and pathways resulting in the formation of an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond. BP
GO:0043451 alkene catabolic process The chemical reactions and pathways resulting in the breakdown of an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond. BP
GO:0016429 tRNA (adenine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. MF
GO:0016428 tRNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. MF
GO:0016427 tRNA (cytosine)-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in a tRNA molecule. MF
GO:0016426 tRNA (adenine)-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in a tRNA molecule. MF
GO:0016424 tRNA (guanosine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanosine residue in a tRNA molecule. MF
GO:0016423 tRNA (guanine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in a tRNA molecule. MF
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. MF
GO:0016421 CoA carboxylase activity NA MF
GO:0016420 malonyltransferase activity Catalysis of the transfer of an malonyl (HOOC-CH2-CO-) group to an acceptor molecule. MF
GO:0020022 acidocalcisome An electron-dense acidic organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. CC
GO:0020023 kinetoplast A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum. CC
GO:0020020 food vacuole Vacuole within a parasite used for digestion of the host cell cytoplasm. CC
GO:0020021 immortalization of host cell The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0020026 dense granule (sensu Apicomplexa) Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell. As in, but not restricted to, the apicomplexans (Apicomplexa, ncbi_taxonomy_id:5794). CC
GO:0020027 hemoglobin metabolic process The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. BP
GO:0020025 subpellicular microtubule Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid. CC
GO:0020028 hemoglobin import The directed movement into a tissue, cell or organelle of externally available hemoglobin. BP
GO:0030676 Rac guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0030677 ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. CC
GO:0030674 protein binding, bridging Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. MF
GO:0030675 Rac GTPase activator activity Increases the rate of GTP hydrolysis by a GTPase of the Rac family. MF
GO:0030672 synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle. CC
GO:0030673 axolemma The plasma membrane of an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. CC
GO:0030670 phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle. CC
GO:0030671 clathrin-coated phagocytic vesicle membrane The lipid bilayer surrounding a clathrin-coated phagocytic vesicle. CC
GO:0030678 mitochondrial ribonuclease P complex A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule. CC
GO:0030679 cyanelle ribonuclease P complex A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. CC
GO:0045078 positive regulation of interferon-gamma biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. BP
GO:0045079 negative regulation of chemokine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. BP
GO:0045074 regulation of interleukin-10 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10. BP
GO:0045075 regulation of interleukin-12 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12. BP
GO:0045076 regulation of interleukin-2 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. BP
GO:0045077 negative regulation of interferon-gamma biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. BP
GO:0045070 positive regulation of viral genome replication Any process that activates or increases the frequency, rate or extent of viral genome replication. BP
GO:0045071 negative regulation of viral genome replication Any process that stops, prevents or reduces the frequency, rate or extent of viral genome replication. BP
GO:0045072 regulation of interferon-gamma biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. BP
GO:0045073 regulation of chemokine biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. BP
GO:0018810 trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene. MF
GO:0055001 muscle cell development The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. BP
GO:0055002 striated muscle cell development The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. BP
GO:0018813 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E )-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde). MF
GO:0055004 atrial cardiac myofibril development The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. BP
GO:0018815 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = CH2CHCOCOOH + 2,5,6-trihydroxy-3-methylpyridine. MF
GO:0055006 cardiac cell development The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. BP
GO:0055007 cardiac muscle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. BP
GO:0055008 cardiac muscle morphogensis The process by which the anatomical structures of cardiac muscle are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0055009 atrial cardiac muscle morphogenesis The process by which the anatomical structure of cardiac atrium muscle is generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0042664 negative regulation of endodermal cell fate specification Any process that restricts, stops or prevents a cell from specifying into an endoderm cell. BP
GO:0042665 regulation of ectodermal cell fate specification Any process that mediates the specification of a cell into an ectoderm cell. BP
GO:0042668 auditory receptor cell fate determination Process by which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0042669 regulation of auditory receptor cell fate specification Any process that mediates the specification of a cell into an auditory hair cell. BP
GO:0046868 mesosome An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins. CC
GO:0046869 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide. BP
GO:0046862 chromoplast membrane The membrane surrounding a chromoplast. CC
GO:0046863 ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate. MF
GO:0046860 glycosome membrane The lipid bilayer surrounding a glycosome. CC
GO:0046861 glyoxysomal membrane The lipid bilayer surrounding a glyoxysome. CC
GO:0046866 tetraterpenoid transport The directed movement of tetraterpenoids into, out of, within or between cells. Tetraterpenoids are terpenoids with eight isoprene units. BP
GO:0046867 carotenoid transport The directed movement of carotenoids into, out of, within or between cells. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. BP
GO:0046864 isoprenoid transport The directed movement of isoprenoids into, out of, within or between cells. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. BP
GO:0046865 terpenoid transport The directed movement of terpenoids into, out of, within or between cells. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups. BP
GO:0002459 adaptive immune response (sensu Myxinidae and Petromyzontidae) An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory), as in, but not restricted to, hagfish and lamprays (Myxinidae, ncbi_taxonomy_id:7762, Petromyzontidae, ncbi_taxonomy_id:7746). BP
GO:0002458 peripheral T cell tolerance induction Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus. BP
GO:0002457 T cell antigen processing and presentation The process by which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0002456 T cell mediated immunity Any process involved in the carrying out of an immune response by a T cell. BP
GO:0002455 humoral immune response mediated by circulating immunoglobulin An immune response dependent upon secreted immunoglobulin. BP
GO:0002454 peripheral B cell deletion The deletion of B cells by apoptosis occurring as part of peripheral tolerance induction and B cell selection. BP
GO:0002453 peripheral B cell anergy Any process contributing to anergy in peripheral B cells. Anergy is a state of functional inactivation and occurs as part of tolerance induction. BP
GO:0002452 B cell receptor editing The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor. BP
GO:0002451 peripheral B cell tolerance induction Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue. BP
GO:0002450 B cell antigen processing and presentation The process by which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0042093 T-helper cell differentiation The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. BP
GO:0042092 T-helper 2 type immune response An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. BP
GO:0042091 interleukin-10 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-10. BP
GO:0042090 interleukin-12 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-12. BP
GO:0042097 interleukin-4 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-4. BP
GO:0042095 interferon-gamma biosynthetic process The chemical reactions and pathways resulting in the formation of interferon-gamma. BP
GO:0042094 interleukin-2 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-2. BP
GO:0042098 T cell proliferation The rapid expansion of a T cell population by cell division. Follows T cell activation. BP
GO:0006361 transcription initiation from RNA polymerase I promoter NA BP
GO:0006360 transcription from RNA polymerase I promoter The synthesis of RNA from a DNA template by RNA polymerase I (Pol I), originating at a Pol I-specific promoter. BP
GO:0006363 transcription termination from RNA polymerase I promoter The process by which transcription by RNA polymerase I is terminated; typically occurs within U-rich regions. BP
GO:0006362 RNA elongation from RNA polymerase I promoter The extension of an RNA molecule after transcription initiation at an RNA polymerase I-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I. BP
GO:0006365 35S primary transcript processing NA BP
GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. BP
GO:0006367 transcription initiation from RNA polymerase II promoter Processes involved in starting transcription from the RNA polymerase II promoter. BP
GO:0006366 transcription from RNA polymerase II promoter The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). BP
GO:0006369 transcription termination from RNA polymerase II promoter Any process by which transcription by RNA polymerase II is terminated. BP
GO:0006368 RNA elongation from RNA polymerase II promoter The extension of an RNA molecule after transcription initiation at an RNA polymerase II-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. BP
GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. BP
GO:0042544 melibiose biosynthetic process The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. BP
GO:0042547 cell wall modification during multidimensional cell growth The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls. BP
GO:0042546 cell wall biosynthetic process The chemical reactions and pathways resulting in the formation of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. BP
GO:0042541 hemoglobin biosynthetic process The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. BP
GO:0042540 hemoglobin catabolic process The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids. BP
GO:0042543 protein amino acid N-linked glycosylation via arginine The posttranslational glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine. BP
GO:0042542 response to hydrogen peroxide A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. BP
GO:0042549 photosystem II stabilization The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. BP
GO:0042548 regulation of photosynthesis, light reaction Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis. BP
GO:0004859 phospholipase inhibitor activity Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. MF
GO:0004858 dUTP pyrophosphatase inhibitor activity Stops, prevents or reduces the activity of dUTP pyrophosphatase. MF
GO:0004855 xanthine oxidase activity Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2. MF
GO:0004854 xanthine dehydrogenase activity Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. MF
GO:0004857 enzyme inhibitor activity Stops, prevents or reduces the activity of an enzyme. MF
GO:0004856 xylulokinase activity Catalysis of the reaction: ATP + D-xylulose = ADP + D-xylulose 5-phosphate. MF
GO:0004851 uroporphyrin-III C-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2. MF
GO:0004850 uridine phosphorylase activity Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. MF
GO:0004853 uroporphyrinogen decarboxylase activity Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. MF
GO:0004852 uroporphyrinogen-III synthase activity Catalysis of the reaction: hydroxymethylbilane = uroporphyrinogen-III + H2O. MF
GO:0050649 testosterone 6-beta-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. MF
GO:0050648 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding Interacting selectively with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. MF
GO:0050641 6-methylsalicylic acid synthase activity Catalysis of the reaction: acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+. MF
GO:0050640 isopenicillin-N N-acyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + isopenicillin-N + H2O = CoA + penicillin-G + L-2-aminohexanedioate. MF
GO:0050643 10-deacetylbaccatin III 10-O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III. MF
GO:0050642 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity Catalysis of the reaction: benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III. MF
GO:0050645 limonoid glucosyltransferase activity Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP. MF
GO:0050644 cis-p-coumarate glucosyltransferase activity Catalysis of the reaction: cis-p-coumarate + UDP-D-glucose = UDP + 4'-O-beta-D-glucosyl-cis-p-coumarate. MF
GO:0050647 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding Interacting selectively with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. MF
GO:0050646 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding Interacting selectively with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds. MF
GO:0050784 cocaine catabolic process The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. BP
GO:0050785 advanced glycation end-product receptor activity Combining with advanced glycation end-products to initiate a change in cell activity. MF
GO:0048738 cardiac muscle development The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. BP
GO:0005109 frizzled binding Interacting selectively with the frizzled (fz) receptor. MF
GO:0002338 B-1b B cell differentiation The process whereby B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5. BP
GO:0002339 B cell selection The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival. BP
GO:0002332 transitional stage B cell differentiation The process whereby immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent. BP
GO:0002333 transitional one stage B cell differentiation The process whereby immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21. BP
GO:0002330 pre-B cell receptor expression The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface. BP
GO:0002331 pre-B cell allelic exclusion Expression of a single heavy chain allele during pre-B cell differentiation. BP
GO:0002336 B-1 B cell lineage commitment The process by which an immature B cell becomes committed to become a B-1 B cell. BP
GO:0002337 B-1a B cell differentiation The process whereby B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors. BP
GO:0002334 transitional two stage B cell differentiation The process whereby immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21. BP
GO:0002335 mature B cell differentiation The process whereby transitional stage B cells acquire the specialized features of mature B cells in the spleen. BP
GO:0004278 granzyme B activity Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa. MF
GO:0051068 dihydrolipoamide metabolic process The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor. BP
GO:0051069 galactomannan metabolic process The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units. BP
GO:0051066 dihydrobiopterin metabolic process The chemical reactions and pathways involving dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions. BP
GO:0051067 dihydropteridine metabolic process The chemical reactions and pathways involving dihydropteridine, a bicyclic compound with the formula C6H6N4. BP
GO:0051064 TTP reductase activity Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. MF
GO:0051065 CTP reductase activity Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. MF
GO:0004275 enteropeptidase activity Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen. MF
GO:0004274 dipeptidyl-peptidase IV activity Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline. MF
GO:0004277 granzyme A activity Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates. MF
GO:0004276 furin activity Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. MF
GO:0010108 detection of glutamine The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal. BP
GO:0010109 regulation of photosynthesis Any process that modulates the frequency, rate or extent of photosynthesis. BP
GO:0010106 cellular response to iron ion starvation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions. BP
GO:0010107 potassium ion import The directed movement of potassium ions into a cell or organelle. BP
GO:0010104 regulation of ethylene mediated signaling pathway Any process that modulates the frequency, rate or extent of ethylene (ethene) mediated signaling. BP
GO:0010105 negative regulation of ethylene mediated signaling pathway Any process that stops or prevents ethylene (ethene) mediated signaling. BP
GO:0010102 lateral root morphogenesis The process by which the anatomical structures of lateral root are generated and organized. Morphogenesis pertains to the creation of form. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. BP
GO:0010103 stomatal complex morphogenesis The process by which the anatomical structures of the stomatal complex are generated and organized. Morphogenesis pertains to the creation of form. The stomatal complex is the stomatal guard cells and their associated epidermal cells. BP
GO:0010100 negative regulation of photomorphogenesis Any process that stops, reduces or prevents photomorphogenesis. BP
GO:0010101 post-embryonic root morphogenesis The process by which the anatomical structures of the post-embryonic root are generated and organized. Morphogenesis pertains to the creation of form. The post-embryonic root is the root formed after the embryonic phase has been completed. BP
GO:0018379 cytochrome c-heme linkage via heme-bis-L-cysteine The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine. BP
GO:0018378 cytochrome c-heme linkage via heme-L-cysteine The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine. BP
GO:0050788 sequestering of mercury The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system. BP
GO:0018377 protein myristoylation The covalent or non-covalent attachment of a myristoyl moiety to a protein. BP
GO:0018376 peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine The posttranslational hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). BP
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. BP
GO:0001739 sex chromatin A condensed mass of chromatin that represents an inactivated X chromosome. CC
GO:0001738 morphogenesis of a polarized epithelium The process by which the anatomical structures of polarized epithelium are generated and organized. Morphogenesis pertains to the creation of form. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. BP
GO:0001733 galactosylceramide sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. MF
GO:0001732 formation of translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. BP
GO:0001731 formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA. BP
GO:0001730 2'-5'-oligoadenylate synthetase activity Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. Requires binding of double-stranded RNA. MF
GO:0001737 establishment of wing hair orientation Orientation of hairs in the wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction. BP
GO:0001736 establishment of planar polarity Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates. BP
GO:0001735 prenylcysteine oxidase activity Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H20 = a prenal + L-cysteine + H202. MF
GO:0001734 mRNA (N6-adenosine)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R = purine, and H = C, A, or U. MF
GO:0018599 2-hydroxyisobutyrate 3-monooxygenase activity Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate. MF
GO:0018598 hydroxymethylsilanetriol oxidase activity Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol. MF
GO:0018591 methyl tertiary butyl ether 3-monooxygenase activity Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde. MF
GO:0018590 methylsilanetriol hydroxylase activity Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol. MF
GO:0018593 4-chlorophenoxyacetate monooxygenase activity Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol. MF
GO:0018592 4-nitrocatechol 4-monooxygenase activity Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + NO2(-) (nitrite) + 1,2,4-benzenetriol. MF
GO:0018595 alpha-pinene monooxygenase activity Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol. MF
GO:0018594 tert-butyl alcohol 2-monooxygenase activity Catalysis of the reaction: tert-butyl alcohol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol. MF
GO:0018597 ammonia monooxygenase activity NA MF
GO:0018596 dimethylsilanediol hydroxylase activity Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol. MF
GO:0016629 12-oxophytodienoate reductase activity Catalysis of the reaction: 8-((1R,2R)-3-oxo-2-((Z)-pent-2-enyl)cyclopentyl)octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + NADPH. MF
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. MF
GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. MF
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. MF
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016621 cinnamoyl-CoA reductase activity Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+. MF
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. MF
GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. MF
GO:0016622 oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome. MF
GO:0019422 disproportionation of elemental sulfur The process by which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2. BP
GO:0019423 sulfur oxidation, ferric ion-dependent NA BP
GO:0019420 dissimilatory sulfate reduction The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide. BP
GO:0019421 sulfate reduction, APS pathway The reduction of sulfate and ATP to adenosine-phosphosulfate (APS) and pyrophosphate. The activated compound APS then participates in a variety of downstream reactions. BP
GO:0019426 bisulfite reduction NA BP
GO:0019427 acetyl-CoA biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate. BP
GO:0019424 sulfide oxidation, using siroheme sulfite reductase NA BP
GO:0019425 sulfur oxidation, using siroheme sulfite reductase NA BP
GO:0019428 allantoin biosynthetic process The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. BP
GO:0019429 fluorene catabolic process The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents. BP
GO:0052081 modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway Any process by which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052080 modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway Any process by which an organism modulates the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052083 negative regulation by symbiont of host cell-mediated immune response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052082 modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway Any process by which an organism modulates the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052085 negative regulation by symbiont of host T-cell mediated immune response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052084 modulation by symbiont of host ethylene-mediated defense response Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052087 negative regulation by symbiont of defense-related host callose deposition Any process by which an organism stops, prevents or reduces the frequency, rate or extent of callose deposition performed by the host as part of its defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052086 negative regulation by symbiont of host B-cell mediated immune response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052089 modulation by symbiont of host salicylic acid-mediated defense response Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052088 modulation by symbiont of host jasmonic acid-mediated defense response Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0016197 endosome transport The directed movement of substances into, out of or mediated by an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation. BP
GO:0016192 vesicle-mediated transport The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. BP
GO:0016191 synaptic vesicle uncoating The removal of the protein coat on a synaptic vesicle. BP
GO:0016199 axon midline choice point recognition The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline. BP
GO:0016198 axon choice point recognition The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth. BP
GO:0007199 G-protein signaling, coupled to cGMP nucleotide second messenger The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase and a subsequent increase in the concentration of cyclic GMP. BP
GO:0007198 serotonin receptor, adenylate cyclase inhibiting pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. BP
GO:0007191 dopamine receptor, adenylate cyclase activating pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP. BP
GO:0007190 adenylate cyclase activation Any process that initiates the activity of the inactive enzyme adenylate cyclase. BP
GO:0007193 G-protein signaling, adenylate cyclase inhibiting pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. BP
GO:0007192 serotonin receptor, adenylate cyclase activating pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP. BP
GO:0007195 dopamine receptor, adenylate cyclase inhibiting pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. BP
GO:0007194 negative regulation of adenylate cyclase activity Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity. BP
GO:0007197 muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. BP
GO:0007196 metabotropic glutamate receptor, adenylate cyclase inhibiting pathway The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. BP
GO:0051326 telophase Progression through telophase, the last stage of chromosome segregation in the cell cycle. Canonically, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. BP
GO:0051859 suppression of symbiont defenses Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051858 avoidance of symbiont defenses Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051857 growth or development of organism on or near symbiont surface The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051856 adhesion to symbiont The attachment of an organism to its symbiont via adhesion molecules, general stickiness etc., either directly or indirectly. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051855 recognition of symbiont The specific processes that allow an organism to detect the presence of its symbiont via physical or chemical signals. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051854 induction in symbiont of tumor, nodule, or growth containing transformed cells The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051853 induction in symbiont of tumor, nodule, or growth The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051852 disruption by host of symbiont cells Any process by which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051851 modification of symbiont morphology or physiology The process by which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051850 acquisition of nutrients from symbiont The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0001849 complement component C1q binding Interacting selectively with the C1q component of the classical complement cascade. MF
GO:0001848 complement binding Interacting selectively with any component or product of the complement cascade. MF
GO:0006924 activated T cell apoptosis The process of apoptosis in activated T cells. BP
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. MF
GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. MF
GO:0008756 o-succinylbenzoate-CoA ligase activity Catalysis of the reaction: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA. MF
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. MF
GO:0008754 O antigen ligase activity NA MF
GO:0008755 O antigen polymerase activity Catalysis of the polymerization of o-antigen chains. O-antigens are tetra and penta saccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide. MF
GO:0008752 FMN reductase activity Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. MF
GO:0008753 NADPH dehydrogenase (quinone) activity Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor. MF
GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. MF
GO:0045467 R7 development The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium. BP
GO:0045466 R7 cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor. BP
GO:0045465 R8 cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor. BP
GO:0045464 R8 cell fate specification Process by which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0045463 R8 development The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium. BP
GO:0045462 trichothecene 3-O-acetyltransferase activity Catalysis of the conversion of isotrichodermol to isotrichodermin. MF
GO:0045461 sterigmatocystin biosynthetic process The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. BP
GO:0045460 sterigmatocystin metabolic process The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. BP
GO:0045469 negative regulation of R8 spacing Any process that stops or prevents the correct R8 spacing pattern. BP
GO:0045468 regulation of R8 spacing Any process that modulates the frequency, rate or extent of the spacing of the R8 cells, ensuring that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc. BP
GO:0035147 tracheal branch fusion Fusing of specific tracheal branches to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint. BP
GO:0035146 tube fusion The joining of specific branches of a tubular system to form a continuous network. BP
GO:0035145 exon-exon junction complex A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. CC
GO:0035144 anal fin morphogenesis The process by which the anatomical structures of the anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. BP
GO:0035143 caudal fin morphogenesis The process by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion. BP
GO:0035142 dorsal fin morphogenesis The process by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. BP
GO:0035141 medial fin morphogenesis The process by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. BP
GO:0035140 arm morphogenesis The process by which the anatomical structures of the arm are generated and organized. Morphogenesis pertains to the creation of form. In humans, the arms are the two upper limbs of the body from the shoulder to the hand. BP
GO:0035149 tracheal lumen formation Creation of the central hole of a tracheal tube through which gases flow. BP
GO:0035148 lumen formation Creation of the central hole of a tube in an antomical structure through which gases and/or liquids flow. BP
GO:0046468 phosphatidyl-N-monomethylethanolamine metabolic process The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria. BP
GO:0046469 platelet activating factor metabolic process The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. BP
GO:0046466 membrane lipid catabolic process The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. BP
GO:0046467 membrane lipid biosynthetic process The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. BP
GO:0046464 acylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. BP
GO:0046465 dolichyl diphosphate metabolic process The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes. BP
GO:0046462 monoacylglycerol metabolic process The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. BP
GO:0046463 acylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. BP
GO:0046460 neutral lipid biosynthetic process The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. BP
GO:0046461 neutral lipid catabolic process The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. BP
GO:0009830 cell wall modification during abscission The series of events that occur during abscission that result in chemical and structural alterations of existing cell walls. BP
GO:0009831 cell wall modification during multidimensional cell growth (sensu Magnoliophyta) The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009832 cell wall biosynthetic process (sensu Magnoliophyta) The chemical reactions and pathways resulting in the formation of the cell wall, as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009833 primary cell wall biosynthetic process (sensu Magnoliophyta) The chemical reactions and pathways resulting in the formation of cell walls that form adjacent to the middle lamella following cell division and during cell expansion. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009834 secondary cell wall biosynthetic process (sensu Magnoliophyta) The chemical reactions and pathways resulting in the formation of inextensible cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0009835 ripening The series of events causing changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) to make it more attractive to animals and/or aid in seed dispersal. BP
GO:0009836 ripening, climacteric A ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset. BP
GO:0043178 alcohol binding Interacting selectively with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. MF
GO:0009838 abscission The controlled shedding of a body part. BP
GO:0043176 amine binding Interacting selectively with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. MF
GO:0043175 RNA polymerase core enzyme binding Interacting selectively with the prokaryotic RNA polymerase core enzyme, the part of the RNA polymerase consisting of two alpha, one beta and one beta prime subunits. MF
GO:0043174 nucleoside salvage Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. BP
GO:0043173 nucleotide salvage Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. BP
GO:0043172 ferredoxin biosynthetic process The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each. BP
GO:0043171 peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. BP
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates. BP
GO:0046288 isoflavonoid catabolic process The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. BP
GO:0046289 isoflavonoid phytoalexin metabolic process The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. BP
GO:0046282 cinnamic acid ester catabolic process The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid. BP
GO:0046283 anthocyanin metabolic process The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers. BP
GO:0046280 chalcone catabolic process The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives. BP
GO:0046281 cinnamic acid catabolic process The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid. BP
GO:0046286 flavonoid phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. BP
GO:0046287 isoflavonoid metabolic process The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring moiety. BP
GO:0046284 anthocyanin catabolic process The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. BP
GO:0046285 flavonoid phytoalexin metabolic process The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. BP
GO:0048538 thymus development The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. BP
GO:0048539 bone marrow development The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. BP
GO:0048536 spleen development The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. BP
GO:0048537 mucosal-associated lymphoid tissue development The process whose specific outcome is the progression of mucosal- associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes. BP
GO:0048534 hemopoietic or lymphoid organ development The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. BP
GO:0048535 lymph node development The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. BP
GO:0048532 organization of an anatomical structure The process that gives rise to the structural organization of an organ or tissue. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048533 sporocyte differentiation The process whereby a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores. BP
GO:0048530 fruit morphogenesis The process by which the anatomical structures of a fruit are generated and organized. Morphogenesis pertains to the creation of form. A fruit is a reproductive body of a seed plant. BP
GO:0048531 beta-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. MF
GO:0048033 heme o metabolic process The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. BP
GO:0048032 galacturonate binding Interacting selectively with any galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. MF
GO:0048280 vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. BP
GO:0048281 inflorescence morphogenesis The process by which the anatomical structures of inflorescences are generated and organized. Morphogenesis pertains to the creation of form. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers. BP
GO:0048282 determinate inflorescence morphogenesis The process by which the anatomical structures of determinate inflorescences are generated and organized. Morphogenesis pertains to the creation of form. A determinate inflorescence is one that can only produce a predetermined number of floral meristems. BP
GO:0048283 indeterminate inflorescence morphogenesis The process by which the anatomical structures of determinate inflorescences are generated and organized. Morphogenesis pertains to the creation of form. A determinate inflorescence is one that can produce an undefined number of floral meristems. BP
GO:0048284 organelle fusion The creation of a single organelle from two or more organelles. BP
GO:0048285 organelle fission The creation of two or more organelles by division of one organelle. BP
GO:0048286 alveolus development The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. BP
GO:0048288 nuclear membrane fusion during karyogamy The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. BP
GO:0048289 isotype switching to IgE isotypes The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus. BP
GO:0048036 central complex development The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli. BP
GO:0048035 heme o catabolic process The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. BP
GO:0006973 intracellular accumulation of glycerol The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment. BP
GO:0005784 translocon complex A translocation complex that constitutes the specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. Composed of a heterotetramer of alpha, beta, gamma and delta subunits (translocon-associated proteins or TRAPs). In yeast it is a heterotrimeric complex consisting of Sec61p, Sbh1p, and Sss1p. The Sec61 complex functions in cotranslational and posttranslational translocation events. CC
GO:0050270 S-adenosylhomocysteine deaminase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = S-inosyl-L-homocysteine + NH3. MF
GO:0009167 purine ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0050272 S-carboxymethylcysteine synthase activity Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride. MF
GO:0050273 S-succinylglutathione hydrolase activity Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + succinate. MF
GO:0009162 deoxyribonucleoside monophosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009163 nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0050276 scyllo-inosamine 4-kinase activity Catalysis of the reaction: ATP + 1-amino-1-deoxy-scyllo-inositol = ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate. MF
GO:0009161 ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0050278 sedoheptulose-bisphosphatase activity Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate. MF
GO:0050279 sepiapterin deaminase activity Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3. MF
GO:0009168 purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009169 purine ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0000365 nuclear mRNA trans splicing, via U2-type spliceosome The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. BP
GO:0000364 second U2-type spliceosomal transesterification activity Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins. MF
GO:0043259 laminin-10 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta1 and gamma1. CC
GO:0002558 type I hypersensitivity mediated by mast cells An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. BP
GO:0002559 type I hypersensitivity mediated by basophils An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. BP
GO:0002552 serotonin secretion by mast cell The regulated release of serotonin by a mast cell or group of mast cells. BP
GO:0002553 histamine secretion by mast cell The regulated release of histamine by a mast cell or group of mast cells. BP
GO:0002550 positive regulation of plasma kallikrein-kinin cascade Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade. BP
GO:0002551 mast cell chemotaxis The movement of a mast cell in response to an external stimulus. BP
GO:0002556 serotonin secretion by basophil The regulated release of serotonin by a basophil or group of basophils. BP
GO:0002557 histamine secretion by basophil The regulated release of histamine by a basophil or group of basophils. BP
GO:0002554 serotonin secretion by platelet The regulated release of serotonin by a platelet or group of platelets. BP
GO:0002555 histamine secretion by platelet The regulated release of histamine by a platelet or group of platelets. BP
GO:0032678 regulation of interleukin-9 production Any process that modulates the frequency, rate, or extent of interleukin-9 production. BP
GO:0032679 regulation of TRAIL production Any process that modulates the frequency, rate, or extent of TRAIL production. BP
GO:0032670 regulation of interleukin-26 production Any process that modulates the frequency, rate, or extent of interleukin-26 production. BP
GO:0032671 regulation of interleukin-27 production Any process that modulates the frequency, rate, or extent of interleukin-27 production. BP
GO:0032672 regulation of interleukin-3 production Any process that modulates the frequency, rate, or extent of interleukin-3 production. BP
GO:0032673 regulation of interleukin-4 production Any process that modulates the frequency, rate, or extent of interleukin-4 production. BP
GO:0032674 regulation of interleukin-5 production Any process that modulates the frequency, rate, or extent of interleukin-5 production. BP
GO:0032675 regulation of interleukin-6 production Any process that modulates the frequency, rate, or extent of interleukin-6 production. BP
GO:0032676 regulation of interleukin-7 production Any process that modulates the frequency, rate, or extent of interleukin-7 production. BP
GO:0032677 regulation of interleukin-8 production Any process that modulates the frequency, rate, or extent of interleukin-8 production. BP
GO:0006668 sphinganine-1-phosphate metabolic process The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. BP
GO:0006669 sphinganine-1-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol. BP
GO:0006660 phosphatidylserine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. BP
GO:0006661 phosphatidylinositol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. BP
GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. BP
GO:0006663 platelet activating factor biosynthetic process The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. BP
GO:0006664 glycolipid metabolic process The chemical reactions and pathways involving glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. BP
GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). BP
GO:0006666 3-keto-sphinganine metabolic process The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine. BP
GO:0006667 sphinganine metabolic process The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol. BP
GO:0005319 lipid transporter activity Enables the directed movement of lipids into, out of, within or between cells. MF
GO:0005310 dicarboxylic acid transporter activity Enables the directed movement of dicarboxylic acids into, out of, within or between cells. A dicarboxylic acid is an organic acid with two COOH groups. MF
GO:0005313 L-glutamate transporter activity Enables the directed movement of L-glutamate, the anion of 2-aminopentanedioic acid, into, out of, within or between cells. MF
GO:0005315 inorganic phosphate transporter activity NA MF
GO:0005314 high-affinity glutamate transporter activity Catalysis of the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). MF
GO:0005316 high affinity inorganic phosphate:sodium symporter activity Catalysis of the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). MF
GO:0000792 heterochromatin A compact and highly condensed form of chromatin. CC
GO:0000793 condensed chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. CC
GO:0000790 nuclear chromatin The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus. CC
GO:0000791 euchromatin A dispersed and relatively uncompacted form of chromatin. CC
GO:0000796 condensin complex A multisubunit protein complex that plays a central role in chromosome condensation. CC
GO:0000797 condensin core heterodimer The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation. CC
GO:0000794 condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus. CC
GO:0000795 synaptonemal complex A proteinaceous scaffold found between homologous chromosomes during meiosis. CC
GO:0000798 nuclear cohesin complex A protein complex required for cohesion between sister chromatids that remain in the nucleus. CC
GO:0000799 nuclear condensin complex A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus. CC
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation Any process that stops, prevents or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. BP
GO:0051185 coenzyme transporter activity Enables the directed movement of a coenzyme into, out of, within or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. MF
GO:0051184 cofactor transporter activity Enables the directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. MF
GO:0051187 cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. BP
GO:0051186 cofactor metabolic process The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. BP
GO:0051181 cofactor transport The directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. BP
GO:0051180 vitamin transport The directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. BP
GO:0051183 vitamin transporter activity Enables the directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. MF
GO:0051182 coenzyme transport The directed movement of a coenzyme into, out of, within or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. BP
GO:0051189 prosthetic group metabolic process The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. BP
GO:0051188 cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. BP
GO:0021814 cell locomotion involved in cerebral cortex glial-mediated radial migration The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration. BP
GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial cell migration Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration. BP
GO:0021816 extension of a leading process involved in cell locomotion in cerebral cortex glial-mediated radial migration The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells. BP
GO:0021817 nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration. BP
GO:0021810 neurotransmitter signaling initiating cell movement, involved in cerebral cortex glial-mediated radial migration Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration. BP
GO:0021811 growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex. BP
GO:0021812 neuronal-glial interaction involved in cerebral cortex glial-mediated radial cell migration The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. BP
GO:0021813 cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial cell migration The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex. BP
GO:0021818 modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial cell migration The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. BP
GO:0021819 layer formation in the cerebral cortex The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. BP
GO:0051239 regulation of multicellular organismal process Any process that modulates the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. BP
GO:0051238 sequestering of metal ion The process of binding or confining metal ions such that they are separated from other components of a biological system. BP
GO:0051237 maintenance of RNA localization The processes by which RNA is maintained in a location and prevented from moving elsewhere. BP
GO:0051236 establishment of RNA localization The directed movement of RNA to a specific location. BP
GO:0051235 maintenance of localization The processes by which a substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. BP
GO:0051234 establishment of localization The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location. BP
GO:0051233 spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap. CC
GO:0051232 meiotic spindle elongation The lengthening of the distance between poles of the spindle during a meiotic cell cycle. BP
GO:0051231 spindle elongation The cell cycle process whereby the distance is lengthened between poles of the spindle. BP
GO:0051230 spindle disassembly The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. BP
GO:0007223 frizzled-2 signaling pathway The series of molecular signals initiated by binding of Wnt protein to a frizzled-2 receptor on the surface of the target cell. BP
GO:0007222 frizzled signaling pathway The series of molecular signals initiated by binding of Wnt protein to a frizzled receptor on the surface of the target cell. BP
GO:0007221 activation of Notch receptor target transcription factor The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain. BP
GO:0007220 Notch receptor processing The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor. BP
GO:0007227 signal transduction downstream of smoothened The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway. BP
GO:0015548 organomercurial transporter activity Enables the directed movement of organomercurial compounds into, out of, within or between cells. Organomercurial substances are any organic compound containing a mercury atom. MF
GO:0007225 patched ligand processing The post translational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties. BP
GO:0007224 smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. BP
GO:0015545 bicyclomycin transporter activity Enables the directed movement of bicyclomycin into, out of, within or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. MF
GO:0015544 phenyl propionate permease activity Catalysis of the reaction: phenyl propionate(out) = phenyl propionate(in). MF
GO:0015547 nalidixic acid transporter activity Enables the directed movement of nalidixic acid into, out of, within or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. MF
GO:0015546 sulfathiazole transporter activity Enables the directed movement of sulfathiazole into, out of, within or between cells. Sulfathiazole is an antibacterial agent of the sulfonamide group. MF
GO:0015541 cyanate porter activity Catalysis of the reaction: cyanate(out) = cyanate(in). MF
GO:0015540 3-hydroxyphenyl propionate porter activity Catalysis of the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in). MF
GO:0015542 sugar efflux transporter activity Catalysis of the reaction: sugar(in) = sugar(out). MF
GO:0019673 GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. BP
GO:0019672 ethanol-acetate fermentation to butyrate and caproate The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP. BP
GO:0019671 glutamate catabolic process via mesaconate and citramalate The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP. BP
GO:0019670 anaerobic glutamate catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP. BP
GO:0019677 NAD catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH. BP
GO:0019676 ammonia assimilation cycle The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen. BP
GO:0019674 NAD metabolic process The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. BP
GO:0019679 propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle. BP
GO:0019678 propionate metabolic process, methylmalonyl pathway The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway. BP
GO:0001948 glycoprotein binding Interacting selectively with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. MF
GO:0001949 sebaceous gland cell differentiation Process whereby a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell. BP
GO:0001940 male pronucleus The pronucleus originating from the spermatozoa that was involved in fertilization. CC
GO:0001941 postsynaptic membrane organization The maintenance of membrane compostition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). BP
GO:0001942 hair follicle development The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. BP
GO:0001944 vasculature development The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. BP
GO:0001945 lymph vessel development The process whose specific outcome is the progression of the lymphatic vasculature over time, from its formation to the mature structure. BP
GO:0001946 lymphangiogenesis Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. BP
GO:0001947 heart looping The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceeding their future integration. BP
GO:0016012 sarcoglycan complex Formed of five N-glycosylated sarcoglycans: alpha-, beta-, gamma-, delta-, and epsilon sarcoglycan, single-pass transmembrane proteins that form a complex which is fixed to the dystrophin axis by a lateral association with the dystroglycan complex. CC
GO:0016013 syntrophin complex Includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase. CC
GO:0016010 dystrophin-associated glycoprotein complex A multiprotein complex that forms the critical link between the cytoskeleton and extracellular matrix; typical of, but not confined, to muscle cells. The constituents of the complex are somewhat tissue specific. The rod-like dystrophin forms a link between the actin cytoskeleton and the plasma membrane; links between dystrophin and the extracellular matrix are provided by the sarcoglycan complex. CC
GO:0016011 dystroglycan complex Includes alpha- and beta-dystroglycan; alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin. CC
GO:0016014 dystrobrevin complex A complex of alpha- and beta-dystrobrevin. CC
GO:0016015 morphogen activity NA MF
GO:0016018 cyclosporin A binding Interacting selectively with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. MF
GO:0016019 peptidoglycan receptor activity Combining with a peptidoglycan to initiate a change in cell activity. MF
GO:0017055 negative regulation of transcriptional preinitiation complex formation Any process that stops, prevents or reduces the frequency, rate or extent of transcriptional preinitiation complex formation. BP
GO:0017054 negative cofactor 2 complex NA CC
GO:0017057 6-phosphogluconolactonase activity Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. MF
GO:0017056 structural constituent of nuclear pore The action of a molecule that contributes to the structural integrity of the nuclear pore complex. MF
GO:0017051 retinol dehydratase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol. MF
GO:0017050 D-erythro-sphingosine kinase activity Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. MF
GO:0017053 transcriptional repressor complex NA CC
GO:0017059 serine C-palmitoyltransferase complex An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine. CC
GO:0017058 FH1 domain binding Interacting selectively with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain. MF
GO:0005076 receptor signaling protein serine/threonine kinase signaling protein activity NA MF
GO:0031758 Edg-5 sphingosine 1-phosphate receptor binding Interacting selectively with an Edg-5 sphingosine 1-phosphate receptor. MF
GO:0031759 Edg-6 sphingosine 1-phosphate receptor binding Interacting selectively with an Edg-6 sphingosine 1-phosphate receptor. MF
GO:0031756 Edg-3 sphingosine 1-phosphate receptor binding Interacting selectively with an Edg-3 sphingosine 1-phosphate receptor. MF
GO:0031757 Edg-4 lysophosphatidic acid receptor binding Interacting selectively with an Edg-4 lysophosphatidic acid receptor. MF
GO:0031754 Edg-1 sphingosine 1-phosphate receptor binding Interacting selectively with an Edg-1 sphingosine 1-phosphate receptor. MF
GO:0031755 Edg-2 lysophosphatidic acid receptor binding Interacting selectively with an Edg-2 lysophosphatidic acid receptor. MF
GO:0031752 D5 dopamine receptor binding Interacting selectively with a D5 dopamine receptor. MF
GO:0031753 endothelial differentiation G-protein coupled receptor binding Interacting selectively with an endothelial differentiation G-protein coupled receptor. MF
GO:0031750 D3 dopamine receptor binding Interacting selectively with a D3 dopamine receptor. MF
GO:0031751 D4 dopamine receptor binding Interacting selectively with a D4 dopamine receptor. MF
GO:0051958 methotrexate transport The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. BP
GO:0051959 dynein light intermediate chain binding Interacting selectively with a light intermediate chain of the dynein complex. MF
GO:0051952 regulation of amine transport Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of, within or between cells. BP
GO:0051953 negative regulation of amine transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amines into, out of, within or between cells. BP
GO:0051950 positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell. BP
GO:0051951 positive regulation of glutamate uptake during transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. BP
GO:0051956 negative regulation of amino acid transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells. BP
GO:0051957 positive regulation of amino acid transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells. BP
GO:0051954 positive regulation of amine transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of, within or between cells. BP
GO:0051955 regulation of amino acid transport Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells. BP
GO:0009365 protein histidine kinase complex A complex that possesses protein histidine kinase activity. CC
GO:0009366 enterobactin synthetase complex A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. CC
GO:0009367 prepilin peptidase complex An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group. CC
GO:0009360 DNA polymerase III complex NA CC
GO:0009361 succinate-CoA ligase complex (ADP-forming) A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. CC
GO:0005251 delayed rectifier potassium channel activity NA MF
GO:0009368 endopeptidase Clp complex An enzymatically active or inactive multimeric complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. CC
GO:0009369 quorum sensing signal generator activity NA MF
GO:0002201 somatic diversification of DSCAM-based immune receptors The somatic process by means of which sequence diversity of the DSCAM-based immune receptors of insects is generated. BP
GO:0002206 gene conversion of immunoglobulin genes The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion. BP
GO:0002207 gene conversion of immunoglobulin genes during immune response The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of an immune response. BP
GO:0002204 somatic recombination of immunoglobulin genes during immune response The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. BP
GO:0048647 polyphenic determination The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues. BP
GO:0008095 inositol-1,4,5-triphosphate receptor activity Combining with inositol-1,4,5-triphosphate to initiate a change in cell activity. MF
GO:0008094 DNA-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of double-stranded DNA; drives another reaction. MF
GO:0008097 5S rRNA binding Interacting selectively with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. MF
GO:0008096 juvenile hormone epoxide hydrolase activity NA MF
GO:0016838 carbon-oxygen lyase activity, acting on phosphates Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. MF
GO:0008090 retrograde axon cargo transport The directed movement of organelles along microtubules from the cell periphery toward the cell body in nerve cell axons. BP
GO:0008093 cytoskeletal adaptor activity NA MF
GO:0008092 cytoskeletal protein binding Interacting selectively with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). MF
GO:0016835 carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond. MF
GO:0016836 hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. MF
GO:0016837 carbon-oxygen lyase activity, acting on polysaccharides Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide. MF
GO:0016830 carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. MF
GO:0016831 carboxy-lyase activity NA MF
GO:0016832 aldehyde-lyase activity Catalyzes the cleavage of a carbon-carbon bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. MF
GO:0016833 oxo-acid-lyase activity NA MF
GO:0008545 JUN kinase kinase activity Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. MF
GO:0008544 epidermis development The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. BP
GO:0008543 fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. BP
GO:0008542 visual learning Any process in an organism in which a change in behavior of an individual in response to repeated exposure to a visual cue. BP
GO:0008541 proteasome regulatory particle, lid subcomplex (sensu Eukaryota) Refers to the subunits of the regulatory particle that forms the peripheral lid, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0008540 proteasome regulatory particle, base subcomplex (sensu Eukaryota) Refers to the subunits of the regulatory particle that directly associates with the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0045342 MHC class II biosynthetic process The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II. BP
GO:0045343 regulation of MHC class I biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. BP
GO:0045340 mercury ion binding Interacting selectively with mercury (Hg) ions. MF
GO:0045341 MHC class I biosynthetic process The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I. BP
GO:0045346 regulation of MHC class II biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. BP
GO:0045347 negative regulation of MHC class II biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. BP
GO:0045344 negative regulation of MHC class I biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. BP
GO:0045345 positive regulation of MHC class I biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I. BP
GO:0045348 positive regulation of MHC class II biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. BP
GO:0045349 interferon-alpha biosynthetic process The chemical reactions and pathways resulting in the formation of interferon-alpha. BP
GO:0047274 galactinol-sucrose galactosyltransferase activity Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol. MF
GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. MF
GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP. MF
GO:0047277 globoside alpha-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. MF
GO:0047270 lipopolysaccharide glucosyltransferase II activity Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP. MF
GO:0047271 glycosaminoglycan galactosyltransferase activity Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP. MF
GO:0047272 phosphopolyprenol glucosyltransferase activity Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP. MF
GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. MF
GO:0047278 bilirubin-glucuronoside glucuronosyltransferase activity Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin-bisglucuronoside + bilirubin. MF
GO:0047279 sn-glycerol-3-phosphate 1-galactosyltransferase activity Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = alpha-D-galactosyl-(1,1')-sn-glycerol 3-phosphate + UDP. MF
GO:0045694 regulation of female gametophyte egg cell differentiation Any process that modulates the frequency, rate or extent of female gametophyte egg cell differentiation. BP
GO:0045695 negative regulation of female gametophyte egg cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of female gametophyte egg cell differentiation. BP
GO:0045696 positive regulation of female gametophyte egg cell differentiation Any process that activates or increases the frequency, rate or extent of female gametophyte egg cell differentiation. BP
GO:0045697 regulation of synergid differentiation Any process that modulates the frequency, rate or extent of synergid cell differentiation. BP
GO:0045690 positive regulation of antipodal cell differentiation Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation. BP
GO:0045691 regulation of female gametophyte central cell differentiation Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation. BP
GO:0045692 negative regulation of female gametophyte central cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of female gametophyte central cell differentiation. BP
GO:0045693 positive regulation of female gametophyte central cell differentiation Any process that activates or increases the frequency, rate or extent of female gametophyte central cell differentiation. BP
GO:0045698 negative regulation of synergid differentiation Any process that stops, prevents or reduces the frequency, rate or extent of synergid cell differentiation. BP
GO:0045699 positive regulation of synergid differentiation Any process that activates or increases the frequency, rate or extent of synergid cell differentiation. BP
GO:0032478 heterotetrameric decaprenyl diphosphate synthase complex A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1. CC
GO:0032479 regulation of interferon type I production Any process that modulates the frequency, rate, or extent of interferon type I production. BP
GO:0032476 decaprenyl diphosphate synthase complex A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. CC
GO:0032477 homodimeric decaprenyl diphosphate synthase complex A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. CC
GO:0032474 otolith morphogenesis The process by which the anatomical structures of an otolith are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0032475 otolith formation The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0032472 Golgi calcium ion transport The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus. BP
GO:0032473 external side of mitochondrial outer membrane The external (cytoplasmic face) of the mitochondrial outer membrane. CC
GO:0032470 elevation of endoplasmic reticulum calcium ion concentration Any process that increases the concentration of calcium ions in the endoplasmic reticulum. BP
GO:0032471 reduction of endoplasmic reticulum calcium ion concentration Any process that decreases the concentration of calcium ions in the endoplasmic reticulum. BP
GO:0030830 negative regulation of cGMP catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP. BP
GO:0030831 positive regulation of cGMP catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP. BP
GO:0030832 regulation of actin filament length Any process that controls the length of actin filaments in a cell. BP
GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. BP
GO:0030834 regulation of actin filament depolymerization Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. BP
GO:0030835 negative regulation of actin filament depolymerization Any process that stops, prevents or reduces the frequency, rate or extent of actin depolymerization. BP
GO:0030836 positive regulation of actin filament depolymerization Any process that activates or increases the frequency, rate or extent of actin depolymerization. BP
GO:0030837 negative regulation of actin filament polymerization Any process that stops, prevents or reduces the frequency, rate or extent of actin polymerization. BP
GO:0030838 positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization. BP
GO:0030839 regulation of intermediate filament polymerization Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament. BP
GO:0015028 coreceptor, insoluble ligand activity NA MF
GO:0015020 glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. MF
GO:0015021 heparin-sulfate lyase activity Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. MF
GO:0015026 coreceptor activity Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. MF
GO:0015027 coreceptor, soluble ligand activity NA MF
GO:0015024 glucuronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. MF
GO:0050850 positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. BP
GO:0050851 antigen receptor-mediated signaling pathway A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. BP
GO:0050852 T cell receptor signaling pathway A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. BP
GO:0050853 B cell receptor signaling pathway A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. BP
GO:0050854 regulation of antigen receptor-mediated signaling pathway Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. BP
GO:0050855 regulation of B cell receptor signaling pathway Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. BP
GO:0050856 regulation of T cell receptor signaling pathway Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. BP
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. BP
GO:0050858 negative regulation of antigen receptor-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. BP
GO:0050859 negative regulation of B cell receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. BP
GO:0046585 enniatin biosynthetic process The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. BP
GO:0046584 enniatin metabolic process The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. BP
GO:0046587 positive regulation of calcium-dependent cell-cell adhesion Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion. BP
GO:0046586 regulation of calcium-dependent cell-cell adhesion Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. BP
GO:0046581 intercellular canaliculus An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates. CC
GO:0046580 negative regulation of Ras protein signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of Ras protein signal transduction. BP
GO:0046583 cation efflux permease activity Catalysis of the stereospecific transfer of cations across a biological membrane out of a cell. MF
GO:0046582 Rap GTPase activator activity Increases the rate of GTP hydrolysis by a GTPase of the Rap family. MF
GO:0046589 ribonuclease T1 activity Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates. MF
GO:0046588 negative regulation of calcium-dependent cell-cell adhesion Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion. BP
GO:0047188 aromatic-hydroxylamine O-acetyltransferase activity Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl. MF
GO:0047189 2,3-diaminopropionate N-oxalyltransferase activity Catalysis of the reaction: L-2,3-diaminopropanoate + oxalyl-CoA = N3-oxalyl-L-23-diaminopropanoate + CoA. MF
GO:0047186 N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA. MF
GO:0047187 deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate. MF
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. MF
GO:0047185 N-acetylneuraminate 4-O-acetyltransferase activity Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA. MF
GO:0047182 alcohol O-cinnamoyltransferase activity Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate. MF
GO:0047183 anthocyanin 5-aromatic acyltransferase activity Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA. MF
GO:0047180 salutaridinol 7-O-acetyltransferase activity Catalysis of the reaction: salutaridinol + acetyl-CoA = 7-O-acetylsalutaridinol + CoA. MF
GO:0047181 benzophenone synthase activity Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A. MF
GO:0046639 negative regulation of alpha-beta T cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell differentiation. BP
GO:0046638 positive regulation of alpha-beta T cell differentiation Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. BP
GO:0046637 regulation of alpha-beta T cell differentiation Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. BP
GO:0046636 negative regulation of alpha-beta T cell activation Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell activation. BP
GO:0046635 positive regulation of alpha-beta T cell activation Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. BP
GO:0046634 regulation of alpha-beta T cell activation Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. BP
GO:0046633 alpha-beta T cell proliferation The rapid expansion of an alpha-beta T cell population by cell division. BP
GO:0046632 alpha-beta T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta T cell. BP
GO:0046631 alpha-beta T cell activation The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. BP
GO:0046630 gamma-delta T cell proliferation The rapid expansion of a gamma-delta T cell population by cell division. BP
GO:0035262 gonad morphogenesis The process by which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. BP
GO:0035263 genital disc sexually dimorphic development The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed. BP
GO:0035260 internal genitalia morphogenesis The process by which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. BP
GO:0035261 external genitalia morphogenesis The process by which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. BP
GO:0035266 meristem growth The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation. BP
GO:0035267 NuA4 histone acetyltransferase complex A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). CC
GO:0035264 body growth The increase in size or mass of an entire organism, as opposed to cell growth. BP
GO:0035265 organ growth The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. BP
GO:0035268 protein amino acid mannosylation The addition of a mannose residue to a protein acceptor molecule. BP
GO:0035269 protein amino acid O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. BP
GO:0030166 proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. BP
GO:0030167 proteoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. BP
GO:0030164 protein denaturation Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds. BP
GO:0030165 PDZ domain binding Interacting selectively with a PDZ domain of a protein, a domain found in diverse signaling proteins. MF
GO:0030162 regulation of proteolysis Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. BP
GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. BP
GO:0030160 GKAP/Homer scaffold activity Functions as a scaffold bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses. MF
GO:0030161 calpain inhibitor activity Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue. MF
GO:0030168 platelet activation A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. BP
GO:0030169 low-density lipoprotein binding Interacting selectively with low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans). MF
GO:0043038 amino acid activation The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. BP
GO:0043039 tRNA aminoacylation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. BP
GO:0043032 positive regulation of macrophage activation Any process that stimulates, induces or increases the rate of macrophage activation. BP
GO:0043033 isoamylase complex A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. CC
GO:0043030 regulation of macrophage activation Any process that modulates the frequency or rate of macrophage activation. BP
GO:0043031 negative regulation of macrophage activation Any process that stops, prevents or reduces the frequency, rate or extent of macrophage activation. BP
GO:0043036 starch grain Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. CC
GO:0043034 costamere Vinculin-containing myofibril attachment site which connects the Z-discs to the sarcolemma. CC
GO:0043035 chromatin insulator sequence binding Interacting selectively and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription. MF
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. MF
GO:0004421 hydroxymethylglutaryl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. MF
GO:0004422 hypoxanthine phosphoribosyltransferase activity Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0004423 iduronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. MF
GO:0004424 imidazoleglycerol-phosphate dehydratase activity Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. MF
GO:0004425 indole-3-glycerol-phosphate synthase activity Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. MF
GO:0004426 indoleamine-pyrrole 2,3-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = N-formylkynurenine. MF
GO:0004427 inorganic diphosphatase activity Catalysis of the reaction: diphosphate + H2O = 2 phosphate. MF
GO:0004428 inositol or phosphatidylinositol kinase activity Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. MF
GO:0008936 nicotinamidase activity Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3. MF
GO:0008937 ferredoxin reductase activity Catalysis of the reactions: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+. MF
GO:0048093 positive regulation of male pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males. BP
GO:0048092 negative regulation of male pigmentation Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in males. BP
GO:0008932 murein lytic endotransglycosylase E activity NA MF
GO:0008933 murein transglycosylase B activity NA MF
GO:0008930 methylthioadenosine nucleosidase activity Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose. MF
GO:0008931 murein DD-endopeptidase activity NA MF
GO:0048099 anterior/posterior lineage restriction, imaginal disc Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment. BP
GO:0048098 antennal joint development The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments. BP
GO:0008938 nicotinate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate. MF
GO:0008939 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Catalysis of the reaction: beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole. MF
GO:0042639 telogen The resting phase of hair cycle. BP
GO:0042638 exogen The shedding phase of the hair cycle. BP
GO:0042633 hair cycle The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. BP
GO:0042632 cholesterol homeostasis Any of the processes involved in the maintenance of an internal equilibrium of cholesterol within an organism or cell. BP
GO:0042631 cellular response to water deprivation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water. BP
GO:0042630 behavioral response to water deprivation A change in the behavior of an organism as a result of deprivation of water. BP
GO:0042637 catagen The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced. BP
GO:0042636 negative regulation of hair cycle Any process that stops, prevents or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. BP
GO:0042635 positive regulation of hair cycle Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. BP
GO:0042634 regulation of hair cycle Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. BP
GO:0018700 2-chloro-N-isopropylacetanilide reductive dehalogenase activity Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide. MF
GO:0018701 2,5-dichlorohydroquinone reductive dehalogenase activity Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone). MF
GO:0018702 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. MF
GO:0018703 2,4-dichlorophenoxyacetate dehalogenase activity Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate. MF
GO:0018704 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde. MF
GO:0018705 1,2-dichloroethene reductive dehalogenase activity Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride. MF
GO:0018706 pyrogallol hydroxytransferase activity Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene. MF
GO:0018707 1-phenanthrol methyltransferase activity Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene. MF
GO:0018708 thiol S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether. MF
GO:0019071 viral DNA cleavage The cleavage of viral DNA into singular functional units. BP
GO:0019070 viral genome maturation Viral processes that occur on newly synthesized viral genomes. BP
GO:0019073 viral DNA genome packaging The packing of viral DNA into a capsid. BP
GO:0019072 viral genome packaging The encapsulation of the viral genome within the capsid. BP
GO:0019075 virus maturation The assembly of the component viral parts into an infectious virion. BP
GO:0019074 viral RNA genome packaging The packaging of viral RNA into a nucleocapsid. BP
GO:0019077 lytic viral release A viral infection and replication that leads to the destruction (lysis) of the infected cell with the release of virions. BP
GO:0019076 release of virus from host The process by which a virus becomes free of a host cell either by the lysis of the host cell or by a non-lytic mechanism. BP
GO:0019079 viral genome replication Any process involved directly in viral genome replication, including viral nucleotide metabolism. BP
GO:0019078 lytic viral budding A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment. BP
GO:0007300 nurse cell to oocyte transport (sensu Insecta) Transfer of constituents synthesized in the nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007301 ovarian ring canal formation Assembly of the intercellular bridges that connect the germ-line cells of a female cyst. BP
GO:0007302 nurse cell nucleus anchoring Attachment of the nurse cell nucleus to the plasma membrane. BP
GO:0007303 cytoplasmic transport, nurse cell to oocyte The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte. BP
GO:0007304 eggshell formation (sensu Insecta) The construction of an eggshell. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007305 vitelline membrane formation (sensu Insecta) Construction of the vitelline membrane portion of an egg shell. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007306 insect chorion formation Construction of the chorion portion of the insect egg shell, which comprises the channels for gas exchange. BP
GO:0007307 chorion gene amplification Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster. BP
GO:0007308 oocyte construction The synthesis, deposition, and organization of a cell of an animal ovary that can then undergo meiosis and form an ovum. BP
GO:0007309 oocyte axis determination The establishment, maintenance and elaboration of an axis in the oocyte. BP
GO:0052376 evasion or tolerance by organism of nitric oxide produced by other organism during symbiotic interaction The process by which an organism avoids the effects of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052374 negative regulation by symbiont of entry into host Any process by which an organism stops, prevents or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. BP
GO:0052373 negative regulation by organism of entry into other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052372 modulation by symbiont of entry into host Any process by which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. BP
GO:0052371 modulation by organism of entry into other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052370 entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction The invasion by an organism of a cell of a second organism by utilizing the second organism's phagocytosis mechanism, where the two organisms are in a symbiotic interaction. BP
GO:0052379 modulation by organism of entry into other organism via phagocytosis during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction. BP
GO:0052378 evasion or tolerance by organism of phytoalexins produced by other organism during symbiotic interaction The process by which an organism avoids the effects of phytoalexins produced as a defense response by the second organism, where the two organisms are in a symbiotic interaction. BP
GO:0001320 age-dependent response to reactive oxygen species during chronological cell aging A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. BP
GO:0001321 age-dependent general metabolic decline during replicative cell aging The process, arising in dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function. BP
GO:0001322 age-dependent response to oxidative stress during replicative cell aging A change in state or activity of a cell or an organism occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism. BP
GO:0001323 age-dependent general metabolic decline during chronological cell aging The process, arising in non-dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function. BP
GO:0001324 age-dependent response to oxidative stress during chronological cell aging A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism. BP
GO:0001325 formation of extrachromosomal circular DNA Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats. BP
GO:0001326 replication of extrachromosomal circular DNA Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication. BP
GO:0005430 synaptic vesicle amine transporter activity Enables the directed movement of amines into, out of or within synaptic vesicles. MF
GO:0005432 calcium:sodium antiporter activity Catalysis of the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). MF
GO:0005436 sodium:phosphate symporter activity Catalysis of the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). MF
GO:0000059 protein import into nucleus, docking The aggregation and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins. BP
GO:0000051 urea cycle intermediate metabolic process The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. BP
GO:0000050 urea cycle A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea. BP
GO:0000053 argininosuccinate metabolic process The chemical reactions and pathways involving argininosuccinate, 2-(Nw-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate. BP
GO:0000052 citrulline metabolic process The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. BP
GO:0000055 ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. BP
GO:0000054 ribosome export from nucleus The directed movement of a ribosome from the nucleus into the cytoplasm. BP
GO:0000056 ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. BP
GO:0004749 ribose phosphate diphosphokinase activity Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0004748 ribonucleoside-diphosphate reductase activity Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. MF
GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. MF
GO:0004740 [pyruvate dehydrogenase (lipoamide)] kinase activity Catalysis of the reaction: ATP + (pyruvate dehydrogenase (lipoamide)) = ADP + (pyruvate dehydrogenase (lipoamide)) phosphate. MF
GO:0004743 pyruvate kinase activity Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. MF
GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. MF
GO:0004745 retinol dehydrogenase activity Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. MF
GO:0004744 retinal isomerase activity Catalysis of the reaction: all-trans-retinal = 11-cis-retinal. MF
GO:0004747 ribokinase activity Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. MF
GO:0004746 riboflavin synthase activity Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. MF
GO:0018069 peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone The posttranslational cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase. BP
GO:0018068 peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine The posttranslational modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases. BP
GO:0018061 peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine The posttranslational modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid. BP
GO:0018060 N-terminal peptidyl-cysteine acid deamination NA BP
GO:0018063 cytochrome c-heme linkage The linkage of cytochromes and other heme proteins to heme. BP
GO:0018062 peptidyl-tryptophan succinylation The posttranslational modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan. BP
GO:0018065 protein-cofactor linkage The covalent linking of a cofactor to a protein. BP
GO:0018064 protein-histidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine. MF
GO:0018067 peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine The posttranslational modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA). BP
GO:0016939 kinesin II complex A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes. CC
GO:0016938 kinesin I complex A complex of two kinesin heavy chains and two kinesin light chains. CC
GO:0016935 glycine-gated chloride channel complex NA CC
GO:0016934 glycine-gated chloride channel activity NA MF
GO:0016937 short-branched-chain-acyl-CoA dehydrogenase activity NA MF
GO:0016936 galactoside binding Interacting selectively with any glycoside in which the sugar moiety is galactose. MF
GO:0016931 vasopressin activated calcium mobilizing receptor activity NA MF
GO:0016933 glycine-gated ion channel activity NA MF
GO:0051378 serotonin binding Interacting selectively with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. MF
GO:0051379 epinephrine binding Interacting selectively with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. MF
GO:0051372 nonmuscle alpha-actinin binding Interacting selectively with nonmuscle isoforms of actinin. Nonmuscle alpha-actinin is found at the leading edge of motile cells, cell adhesion sites, focal contacts and along actin stress fibers in migrating cells. MF
GO:0051373 FATZ binding Interacting selectively with a family of FATZ proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. MF
GO:0051370 ZASP binding Interacting selectively with Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain. MF
GO:0051371 muscle alpha-actinin binding Interacting selectively with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. MF
GO:0051376 FATZ 3 binding Interacting selectively with FATZ 3, a protein of the FATZ family that is highly expressed in skeletal muscle fast fiber. MF
GO:0051377 mannose-ethanolamine phosphotransferase activity Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. MF
GO:0051374 FATZ 1 binding Interacting selectively with FATZ 1, a protein of FATZ family that is highly expressed in skeletal muscle fast fiber. MF
GO:0051375 FATZ 2 binding Interacting selectively with FATZ 2, a protein of the FATZ family that is highly expressed in skeletal muscle fiber fast IIa and slow I and in cardiac muscle. MF
GO:0021605 cranial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. BP
GO:0021604 cranial nerve structural organization The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. BP
GO:0021607 accessory nerve morphogenesis The process by which the anatomical structure of the accessory nerve is generated and organized. Morphogenesis pertains to the creation of form. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. BP
GO:0021606 accessory nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. BP
GO:0021601 abducens nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. BP
GO:0021600 abducens nerve structural organization The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. BP
GO:0021603 cranial nerve formation The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. BP
GO:0021602 cranial nerve morphogenesis The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. BP
GO:0021609 accessory nerve structural organization The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. BP
GO:0021608 accessory nerve formation The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. BP
GO:0016203 muscle attachment The developmental process by which a skeletal muscle attaches to a bone. BP
GO:0016202 regulation of striated muscle development Any process that modulates the frequency, rate or extent of striated muscle development. BP
GO:0016201 synaptic target inhibition The process by which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source. BP
GO:0016200 synaptic target attraction The process by which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets. BP
GO:0016207 4-coumarate-CoA ligase activity Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA. MF
GO:0016206 catechol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. MF
GO:0016205 selenocysteine methyltransferase activity Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine. MF
GO:0016204 determination of muscle attachment site The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site. BP
GO:0046035 CMP metabolic process The chemical reactions and pathways involving CMP, cytidine monophosphate. BP
GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. BP
GO:0016209 antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. MF
GO:0016208 AMP binding Interacting selectively with AMP, adenosine monophosphate. MF
GO:0046031 ADP metabolic process The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. BP
GO:0046030 inositol trisphosphate phosphatase activity Catalysis of the removal of one of the three phosphate groups of an inositol trisphosphate. MF
GO:0046033 AMP metabolic process The chemical reactions and pathways involving AMP, adenosine monophosphate. BP
GO:0046032 ADP catabolic process The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate. BP
GO:0030366 Mo-molybdopterin synthase activity Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. MF
GO:0030367 interleukin-17 receptor binding Interacting selectively with the interleukin-17 receptor. MF
GO:0030360 protein phosphatase type 4 activity NA MF
GO:0030362 protein phosphatase type 4 regulator activity Modulation of the activity of the enzyme protein phosphatase type 4. MF
GO:0030368 interleukin-17 receptor activity Combining with interleukin-17 to initiate a change in cell activity. MF
GO:0030369 ICAM-3 receptor activity Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. MF
GO:0047849 dextransucrase activity Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1). MF
GO:0047848 dephospho-[reductase kinase] kinase activity Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]. MF
GO:0047843 dehydrogluconate dehydrogenase activity Catalysis of the reaction: 2-dehydro-D-gluconate + acceptor = 2,5-didehydro-D-gluconate + reduced acceptor. MF
GO:0047842 dehydro-L-gulonate decarboxylase activity Catalysis of the reaction: 3-dehydro-L-gulonate = L-xylulose + CO2. MF
GO:0047841 dehydrogluconokinase activity Catalysis of the reaction: ATP + 2-dehydro-D-gluconate = ADP + 6-phospho-2-dehydro-D-gluconate. MF
GO:0047840 dCTP diphosphatase activity Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate. MF
GO:0047847 deoxyuridine phosphorylase activity Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate. MF
GO:0047846 deoxynucleotide 3'-phosphatase activity Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate. MF
GO:0047845 deoxylimonate A-ring-lactonase activity Catalysis of the reaction: deoxylimonate + H2O = deoxylimononic acid D-ring-lactone. MF
GO:0047844 deoxycytidine deaminase activity Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3. MF
GO:0031095 platelet dense tubular network membrane The lipid bilayer surrounding the platelet dense tubular network. CC
GO:0031094 platelet dense tubular network A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. CC
GO:0031097 medial ring A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning. CC
GO:0031096 platelet dense tubular network lumen The volume enclosed by the membranes of the platelet dense tubular network. CC
GO:0031091 platelet alpha granule A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). CC
GO:0031090 organelle membrane The lipid bilayer surrounding an organelle. CC
GO:0031093 platelet alpha granule lumen The volume enclosed by the membrane of the platelet alpha granule. CC
GO:0031092 platelet alpha granule membrane The lipid bilayer surrounding the platelet alpha granule. CC
GO:0031099 regeneration The regrowth of a lost or destroyed body part, such as an organ or tissue. BP
GO:0031098 stress-activated protein kinase signaling pathway A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. BP
GO:0031549 negative regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. BP
GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. BP
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands. BP
GO:0031546 brain-derived neurotrophic factor receptor binding Interacting selectively with the brain-derived neurotrophic factor receptor. MF
GO:0031545 peptidyl-proline 4-dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. MF
GO:0031544 peptidyl-proline 3-dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. MF
GO:0031543 peptidyl-proline dioxygenase activity Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein. MF
GO:0031542 positive regulation of anthocyanin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. BP
GO:0031541 negative regulation of anthocyanin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. BP
GO:0031540 regulation of anthocyanin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins. BP
GO:0009535 thylakoid membrane (sensu Viridiplantae) The pigmented membrane of a thylakoid. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0009534 thylakoid (sensu Viridiplantae) Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0009537 proplastid The precursor of other plastids. CC
GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. CC
GO:0009531 secondary cell wall A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin. CC
GO:0009530 primary cell wall A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present. CC
GO:0009533 chloroplast stromal thylakoid Unstacked thylakoids that connect the grana stacks through the stroma. CC
GO:0009532 plastid stroma The proteinaceous ground substance of plastids. CC
GO:0009539 photosystem II reaction center An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone. CC
GO:0009538 photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. CC
GO:0043658 host symbiosome A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell. CC
GO:0043659 symbiosome A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane). CC
GO:0043652 engulfment of apoptotic cell The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte. BP
GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. MF
GO:0043650 dicarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. BP
GO:0043651 linoleic acid metabolic process The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. BP
GO:0008666 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Catalysis of the reaction: succinyl-CoA + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. MF
GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. MF
GO:0008664 2'-5'-RNA ligase activity NA MF
GO:0008665 2'-phosphotransferase activity Catalysis of the transfer of a 2'-phosphate group from one compound to another. MF
GO:0045553 TRAIL biosynthetic process The chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptosis in a wide variety of cells. BP
GO:0045552 dihydrokaempferol 4-reductase activity Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. MF
GO:0045551 cinnamyl-alcohol dehydrogenase activity Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. MF
GO:0045550 geranylgeranyl reductase activity Catalysis of the formation of phytyl moiety from the stepwise reduction of a geranylgeranyl moiety. MF
GO:0045557 TRAIL receptor biosynthetic process The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. BP
GO:0045556 positive regulation of TRAIL biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand. BP
GO:0045555 negative regulation of TRAIL biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand. BP
GO:0045554 regulation of TRAIL biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand. BP
GO:0045559 TRAIL receptor 2 biosynthetic process The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. BP
GO:0045558 TRAIL receptor 1 biosynthetic process The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway. BP
GO:0042019 interleukin-23 binding Interacting selectively with interleukin-23. MF
GO:0042018 interleukin-22 receptor activity Combining with interleukin-22 to initiate a change in cell activity. MF
GO:0042013 interleukin-19 binding Interacting selectively with interleukin-19. MF
GO:0042012 interleukin-16 receptor activity Combining with interleukin-16 to initiate a change in cell activity. MF
GO:0042011 interleukin-16 binding Interacting selectively with interleukin-16. MF
GO:0042010 interleukin-15 receptor activity Combining with interleukin-15 to initiate a change in cell activity. MF
GO:0042017 interleukin-22 binding Interacting selectively with interleukin-22. MF
GO:0042016 interleukin-20 receptor activity Combining with interleukin-20 to initiate a change in cell activity. MF
GO:0042015 interleukin-20 binding Interacting selectively with interleukin-20. MF
GO:0042014 interleukin-19 receptor activity Combining with interleukin-19 to initiate a change in cell activity. MF
GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]. MF
GO:0047024 3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NADP+ + 5-alpha-androstan-3-beta,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADPH + H+. MF
GO:0047027 benzyl-2-methyl-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: NADP+ + benzyl (2R,3S)-2-methyl-3-hydroxybutanoate = NADPH + H+ + benzyl 2-methyl-3-oxobutanoate. MF
GO:0047026 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. MF
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate = NADPH + H+ + (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate. MF
GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. MF
GO:0047023 3(or 17)-alpha-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. MF
GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + 7-beta-hydroxysteroid = NADPH + H+ + 7-oxosteroid. MF
GO:0047029 (R)-4-hydroxyphenyllactate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate = NAD(P)H + H+ + 3-(4-hydroxyphenyl)pyruvate. MF
GO:0047028 6-pyruvoyltetrahydropterin 2'-reductase activity Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin. MF
GO:0031936 negative regulation of chromatin silencing Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing. BP
GO:0031937 positive regulation of chromatin silencing Any process that activates or increases the frequency, rate or extent of chromatin silencing. BP
GO:0031934 mating-type region heterochromatin Heterochromatic regions of the chromosome found at silenced mating-type loci. CC
GO:0031935 regulation of chromatin silencing Any process that affects the rate, extent or location of chromatin silencing. BP
GO:0031932 TORC 2 complex A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization. CC
GO:0031933 telomeric heterochromatin Heterochromatic regions of the chromosome found at the telomeres. CC
GO:0031930 mitochondrial signaling pathway A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function. BP
GO:0031931 TORC 1 complex A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy. CC
GO:0031938 regulation of chromatin silencing at telomere Any process that affects the rate, extent or location of chromatin silencing at telomeres. BP
GO:0031939 negative regulation of chromatin silencing at telomere Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing at telomeres. BP
GO:0046778 modification by virus of host mRNA processing Viral processes that interfere with the processing of mRNA in the host cell. BP
GO:0046779 suppression by virus of expression of host genes with introns Viral processes that discriminate against and subsequently inhibit host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed. BP
GO:0046772 virus budding from outer nuclear membrane during viral capsid envelopment The envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope. BP
GO:0046773 suppression by virus of host termination of protein biosynthetic process Viral processes that inhibit the termination of host cell protein biosynthesis that occurs in response to viral infection. BP
GO:0046770 virus budding from outer nuclear membrane during viral capsid re-envelopment The re-envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring an additional membrane envelope. BP
GO:0046771 virus budding from inner nuclear membrane during viral capsid envelopment The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring a membrane envelope. BP
GO:0046776 suppression by virus of MHC class I cell surface presentation in host Viral processes that result in the inhibition of presentation of MHC class I antigen-presenting proteins on the host cell surface. BP
GO:0046777 protein amino acid autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. BP
GO:0046774 suppression by virus of intracellular interferon activity in host Viral processes that result in the inhibition of interferon activity within the host cell. BP
GO:0046775 suppression by virus of host cytokine production Viral processes that result in the inhibition of host cell cytokine production. BP
GO:0005638 lamin filament Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C. CC
GO:0005639 integral to nuclear inner membrane Penetrating at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0005637 nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. CC
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. CC
GO:0005635 nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). CC
GO:0005632 inner layer of spore wall Either of the two innermost layers of the spore wall, as described in Saccharomyces. CC
GO:0005633 ascus lipid droplet Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins. CC
GO:0005630 dityrosine layer of spore wall The outermost layer of the spore wall, as described in Saccharomyces. CC
GO:0005631 chitosan layer of spore wall The second outermost layer of the spore wall, as described in Saccharomyces. CC
GO:0009988 cell-cell recognition Cell recognition between cells, usually involving the formation of specialized cell junctions. BP
GO:0009989 cell-matrix recognition Cell recognition that involves the interaction of the cell with the extracellular matrix. BP
GO:0009985 dihydroflavonol(thiole) lyase activity NA MF
GO:0009986 cell surface The external part of the cell wall and/or cell membrane. CC
GO:0009987 cellular process Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. BP
GO:0009980 glutamate carboxypeptidase activity Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups. MF
GO:0009982 pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. MF
GO:0009983 tyrosine aminopeptidase activity Catalysis of the release of N-terminal tyrosine from a peptide. MF
GO:0005183 luteinizing hormone-releasing factor activity NA MF
GO:0005184 neuropeptide hormone activity The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. MF
GO:0005185 neurohypophyseal hormone activity NA MF
GO:0005186 pheromone activity The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant. MF
GO:0009104 lipopolysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. BP
GO:0009105 lipoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids. BP
GO:0009106 lipoate metabolic process The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. BP
GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. BP
GO:0050252 retinol O-fatty-acyltransferase activity Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. MF
GO:0009101 glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. BP
GO:0050250 retinal oxidase activity Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2. MF
GO:0004589 orotate reductase (NADH) activity Catalysis of the reaction: (S)-dihydroorotate + NAD+ = orotate + NADH + H+. MF
GO:0004588 orotate phosphoribosyltransferase activity Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0004587 ornithine-oxo-acid transaminase activity Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. MF
GO:0004586 ornithine decarboxylase activity Catalysis of the reaction: L-ornithine = putrescine + CO2. MF
GO:0004585 ornithine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. MF
GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide. MF
GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity NA MF
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. MF
GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. MF
GO:0048110 oocyte construction (sensu Insecta) The synthesis, deposition, and organization of a cell of an ovary that can then undergo meiosis and form an ovum. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048111 oocyte axis determination (sensu Insecta) The establishment, maintenance and elaboration of an axis in the oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048112 oocyte anterior/posterior axis determination (sensu Insecta) Polarization of the oocyte along its anterior-posterior axis. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). In Drosophila, for example, this relies on the correct targeting of bicoid (bcd) and oskar (osk) mRNAs to opposite poles of the oocyte (anterior and posterior, respectively). BP
GO:0048113 pole plasm assembly (sensu Insecta) Establishment of the specialized cytoplasm found at the poles of the insect egg. The posterior pole plasm is both necessary and sufficient for the formation of germ cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0018511 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity Catalysis of the reaction: cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ = 2,3-dihydroxy-p-cumate + NADH + H+. MF
GO:0052556 positive regulation by symbiont of host immune response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052555 positive regulation by organism of immune response of other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. BP
GO:0018512 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+. MF
GO:0052553 modulation by symbiont of host immune response Any process by which an organism modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0018514 terephthalate 1,2-cis-dihydrodiol dehydrogenase activity Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH + H+. MF
GO:0052551 response to defense-related nitric oxide production by other organism during symbiotic interaction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052550 response to defense-related reactive oxygen species production by other organism during symbiotic interaction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0018519 cis-dihydroethylcatechol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + NADH + H+. MF
GO:0018518 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H+. MF
GO:0052559 induction by symbiont of host immune response Any process by which an organism activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052558 induction by organism of immune response of other organism during symbiotic interaction Any process by which an organism activates the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. BP
GO:0003914 DNA (6-4) photolyase activity Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. MF
GO:0003917 DNA topoisomerase type I activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. MF
GO:0003916 DNA topoisomerase activity Catalysis of a topological transformation in double-stranded DNA by a covalent or non-covalent mechanism. MF
GO:0003911 DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). MF
GO:0003910 DNA ligase (ATP) activity Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). MF
GO:0003913 DNA photolyase activity Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. MF
GO:0003912 DNA nucleotidylexotransferase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). MF
GO:0003919 FMN adenylyltransferase activity Catalysis of the reaction: ATP + FMN = diphosphate + FAD. MF
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. MF
GO:0042848 sorbose catabolic process The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. BP
GO:0042849 L-sorbose biosynthetic process The chemical reactions and pathways resulting in the formation of L-sorbose, the levorotatory isomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol. BP
GO:0042840 D-glucuronate catabolic process The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the dextrorotatory isomer of glucuronate. BP
GO:0042841 D-glucuronate biosynthetic process The chemical reactions and pathways resulting in the formation of D-glucuronate, the dextrorotatory isomer of glucuronate. BP
GO:0042842 D-xylose biosynthetic process The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide. BP
GO:0042843 D-xylose catabolic process The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide. BP
GO:0042844 glycol metabolic process The chemical reactions and pathways involving glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule. BP
GO:0042845 glycol biosynthetic process The chemical reactions and pathways resulting in the formation of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule. BP
GO:0042846 glycol catabolic process The chemical reactions and pathways resulting in the breakdown of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule. BP
GO:0042847 sorbose biosynthetic process The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. BP
GO:0048876 retinal chemical homeostasis The processes involved in the maintenance of the internal equilibrium of the amount of a chemical at the level of the retina. BP
GO:0048872 homeostasis of number of cells The biological processes involved in the maintenance of the equilibrium of cell number within a population of cells. BP
GO:0048871 multicellular organismal homeostasis The processes involved in the maintenance of an internal equilibrium at the level of the multicellular organism. BP
GO:0050348 trehalose O-mycolyltransferase activity Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate. MF
GO:0050349 triacetate-lactonase activity Catalysis of the reaction: triacetate lactone + H2O = triacetate. MF
GO:0050344 trans-cinnamate 2-monooxygenase activity Catalysis of the reaction: trans-cinnamate + NADPH + O2 = 2-hydroxycinnamate + NADP+ + H2O. MF
GO:0050345 trans-epoxysuccinate hydrolase activity Catalysis of the reaction: H2O + trans-2,3-epoxysuccinate = meso-tartrate. MF
GO:0050346 trans-L-3-hydroxyproline dehydratase activity Catalysis of the reaction: trans-L-3-hydroxyproline = H2O + delta(1)-pyrroline_2-carboxylate. MF
GO:0050347 trans-octaprenyltranstransferase activity Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate. MF
GO:0050340 thymidylate 5'-phosphatase activity Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate. MF
GO:0050341 thymine dioxygenase activity Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2. MF
GO:0050342 tocopherol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol. MF
GO:0050343 trans-2-enoyl-CoA reductase (NAD+) activity Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH. MF
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor protein activity NA MF
GO:0051769 regulation of nitric-oxide synthase biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase. BP
GO:0051768 nitric-oxide synthase 2 biosynthetic process The chemical reactions and pathways resulting in the formation of nitric-oxide synthase 2, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. BP
GO:0051765 inositol tetrakisphosphate kinase activity Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. MF
GO:0051764 actin crosslink formation The process by which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. BP
GO:0051767 nitric-oxide synthase biosynthetic process The chemical reactions and pathways resulting in the formation of nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. BP
GO:0051766 inositol trisphosphate kinase activity Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. MF
GO:0051761 sesquiterpene metabolic process The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. BP
GO:0051760 meiotic sister chromatid cohesion, arms The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis. BP
GO:0051763 sesquiterpene catabolic process The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. BP
GO:0051762 sesquiterpene biosynthetic process The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. BP
GO:0007111 cytokinesis after meiosis II The processes resulting in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells. BP
GO:0007110 cytokinesis after meiosis I The processes resulting in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells. BP
GO:0007113 endomitotic cell cycle The replication and division of chromosomes which is not followed by nuclear division, resulting in an increased number of chromosomes in the cell. BP
GO:0007112 male meiosis cytokinesis The processes resulting in the division of the cytoplasm of a cell to produce two daughter cells that occur during male meiosis. BP
GO:0007114 cell budding A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell. BP
GO:0007117 budding cell bud growth The process by which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. BP
GO:0007116 regulation of cell budding Any process that modulates the frequency, rate or extent of the formation and growth of cell buds. BP
GO:0007119 budding cell isotropic bud growth Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding. BP
GO:0007118 budding cell apical bud growth Growth at the tip of a bud, in a cell that reproduces by budding. BP
GO:0052232 positive aerotaxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052233 positive aerotaxis within other organism during symbiotic interaction The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052230 modulation of intracellular transport in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052231 modulation of phagocytosis in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052236 negative chemotaxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052237 aerotaxis within other organism during symbiotic interaction The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052234 negative aerotaxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052235 negative aerotaxis within other organism during symbiotic interaction The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052238 aerotaxis on or near other organism during symbiotic interaction The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052239 negative chemotaxis within other organism during symbiotic interaction The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO. MF
GO:0010309 acireductone dioxygenase (Fe2+-requiring) activity Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate. MF
GO:0010304 PSII associated light-harvesting complex II catabolic process Catabolism of one or more components of the light-harvesting complex of photosystem II. BP
GO:0010305 leaf vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the leaf of vascular plants. BP
GO:0010306 rhamnogalacturonan II biosynthetic process The formation from simpler components of rhamonogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms. BP
GO:0010307 acetylglutamate kinase regulator activity Modulates the enzyme activity of acetylglutamate kinase. MF
GO:0010300 acyl-ACP synthetase activity Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. MF
GO:0010301 xanthoxin dehydrogenase activity Catalysis of the reaction: xanthoxin + NAD+ = abscisic aldehyde + NADH + H+. MF
GO:0010302 2-oxoglutarate-dependent dioxygenase activity Hydroxylase, with 2-oxoglutarate as one donor, and incorporation or reduction of one atom each of oxygen into both donors. MF
GO:0010303 limit dextrinase activity Catalysis of the hydrolysis of (16)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan. MF
GO:0065001 specification of axis polarity NA BP
GO:0032381 negative regulation of intracellular sterol transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells. BP
GO:0065009 regulation of a molecular function Any process that modulates the frequency, rate or extent of molecular functions. Molecular functions are elemental biological activities occurring at the molecular level, such as catalysis or binding. BP
GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. BP
GO:0032828 positive regulation of natural killer cell differentiation during immune response Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation during an immune response. BP
GO:0032825 positive regulation of natural killer cell differentiation Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation. BP
GO:0032824 negative regulation of natural killer cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation. BP
GO:0032827 negative regulation of natural killer cell differentiation during immune response Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation during an immune response. BP
GO:0032826 regulation of natural killer cell differentiation during immune response Any process that modulates the frequency, rate or extent of natural killer cell differentiation during an immune response. BP
GO:0032821 negative regulation of natural killer cell proliferation during immune response Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation during an immune response. BP
GO:0032820 regulation of natural killer cell proliferation during immune response Any process that modulates the frequency, rate or extent of natural killer cell proliferation during an immune response. BP
GO:0032823 regulation of natural killer cell differentiation Any process that modulates the frequency, rate or extent of natural killer cell differentiation. BP
GO:0032822 positive regulation of natural killer cell proliferation during immune response Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation during an immune response. BP
GO:0015478 oligosaccharide transporting porin activity NA MF
GO:0015471 nucleoside-specific channel forming porin activity NA MF
GO:0015473 fimbrial usher porin activity A porin that acts in the assembly of fimbria together with fimbrial chaperone. MF
GO:0015475 adhesin autotransporter activity NA MF
GO:0015474 autotransporter activity Transports a protein virulence factor from the periplasm to the external milieu; the virulence factor and the porin are the N- and C-terminal regions of the same protein, respectively. MF
GO:0015477 receptor porin activity A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane. MF
GO:0015476 hemaglutinin autotransporter activity NA MF
GO:0047559 3-dehydro-L-gulonate 2-dehydrogenase activity Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+. MF
GO:0047558 3-cyanoalanine hydratase activity Catalysis of the reaction: L-asparagine = 3-cyanoalanine + H2O. MF
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. MF
GO:0047554 2-pyrone-4,6-dicarboxylate lactonase activity Catalysis of the reaction: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate. MF
GO:0047557 3-aci-nitropropanoate oxidase activity Catalysis of the reaction: H2O + O2 + 3-aci-nitropropanoate = NO2(-) (nitrite) + H2O2 + 3-oxopropanoate. MF
GO:0047556 3,4-dihydroxyphthalate decarboxylase activity Catalysis of the reaction: 3,4-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. MF
GO:0047551 2-oxoaldehyde dehydrogenase (NAD) activity Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+. MF
GO:0047550 2-oxoadipate reductase activity Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + NADH + H+. MF
GO:0047553 2-oxoglutarate synthase activity Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin. MF
GO:0047552 2-oxoaldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+. MF
GO:0043249 erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. BP
GO:0043248 proteasome assembly The aggregation and bonding together of a mature, active proteasome complex. BP
GO:0043245 extraorganismal space The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms. CC
GO:0043244 regulation of protein complex disassembly Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. BP
GO:0043247 telomere maintenance in response to DNA damage The processes that occur in response to the presence of critically short telomeres. BP
GO:0043246 megasome Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex. CC
GO:0043241 protein complex disassembly The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. BP
GO:0043240 Fanconi anaemia nuclear complex A protein complex composed of the Fanconi anaemia (FA) proteins A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. CC
GO:0043243 positive regulation of protein complex disassembly Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. BP
GO:0043242 negative regulation of protein complex disassembly Any process that stops, prevents or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. BP
GO:0046202 cyanide biosynthetic process The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. BP
GO:0046203 spermidine catabolic process The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. BP
GO:0046201 cyanate biosynthetic process The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid. BP
GO:0046206 trypanothione metabolic process The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress. BP
GO:0046207 trypanothione catabolic process The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress. BP
GO:0046204 nor-spermidine metabolic process The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. BP
GO:0046205 nor-spermidine catabolic process The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. BP
GO:0046208 spermine catabolic process The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. BP
GO:0046209 nitric oxide metabolic process The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. BP
GO:0032222 regulation of synaptic transmission, cholinergic Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. BP
GO:0045957 negative regulation of complement activation, alternative pathway Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the alternative pathway. BP
GO:0047726 iron-cytochrome-c reductase activity Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+. MF
GO:0045955 negative regulation of calcium ion-dependent exocytosis Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. BP
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity. BP
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. BP
GO:0045952 regulation of juvenile hormone catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone. BP
GO:0045951 positive regulation of mitotic recombination Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis. BP
GO:0045950 negative regulation of mitotic recombination Any process that inhibits or decreases the rate of DNA recombination during mitosis. BP
GO:0047724 inosine nucleosidase activity Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine. MF
GO:0045959 negative regulation of complement activation, classical pathway Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the classical pathway. BP
GO:0045958 positive regulation of complement activation, alternative pathway Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway. BP
GO:0047725 inulosucrase activity Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1). MF
GO:0047722 indolelactate dehydrogenase activity Catalysis of the reaction: indolelactate + NAD+ = indolepyruvate + NADH. MF
GO:0006529 asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. BP
GO:0047723 inosinate nucleosidase activity Catalysis of the reaction: 5'-inosinate + H2O = D-ribose 5-phosphate + hypoxanthine. MF
GO:0006528 asparagine metabolic process The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid. BP
GO:0047720 indoleacetaldoxime dehydratase activity Catalysis of the reaction: indole-3-acetaldoxime = indole-3-acetonitrile + H2O. MF
GO:0047721 indoleacetate-lysine synthetase activity Catalysis of the reaction: ATP + indoleacetate + L-lysine = ADP + phosphate + N6-[(indole-3-yl)acetyl]-L-lysine. MF
GO:0030534 adult behavior Behavior in a fully developed and mature organism. BP
GO:0030537 larval behavior Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics. BP
GO:0030536 larval feeding behavior Feeding behavior in a larval (immature) organism. BP
GO:0030531 small cytoplasmic ribonucleoprotein complex A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm. CC
GO:0030530 heterogeneous nuclear ribonucleoprotein complex Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA. CC
GO:0030533 triplet codon-amino acid adaptor activity Mediates the insertion of an amino acid at the correct point in the sequence of a nascent polypeptide chain during protein synthesis. MF
GO:0030532 small nuclear ribonucleoprotein complex A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. CC
GO:0030539 male genitalia development The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. BP
GO:0030538 embryonic genitalia morphogenesis The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0018414 nickel incorporation into metallo-sulfur cluster The incorporation of nickel into a metallo-sulfur cluster. BP
GO:0042219 amino acid derivative catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. BP
GO:0042218 1-aminocyclopropane-1-carboxylate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. BP
GO:0008849 enterochelin esterase activity NA MF
GO:0006868 glutamine transport The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of, within or between cells. BP
GO:0018413 peptidyl-serine O-glucuronidation The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine. BP
GO:0003810 protein-glutamine gamma-glutamyltransferase activity Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. MF
GO:0006867 asparagine transport The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of, within or between cells. BP
GO:0008840 dihydrodipicolinate synthase activity Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. MF
GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells. BP
GO:0008846 endopeptidase La activity Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP. MF
GO:0018419 protein catenane formation The aggregation and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain. BP
GO:0003816 complement component C1s activity Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond). MF
GO:0031668 cellular response to extracellular stimulus NA BP
GO:0031669 cellular response to nutrient levels A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. BP
GO:0031662 G2/M-specific positive regulation of cyclin-dependent protein kinase activity Any process that activates or increases the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle. BP
GO:0031663 lipopolysaccharide-mediated signaling pathway The series of molecular signals generated in response to detection of lipopolysaccharide. BP
GO:0031660 G2/M-specific regulation of cyclin-dependent protein kinase activity Any process that modulates the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle. BP
GO:0031661 G2/M-specific negative regulation of cyclin-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle. BP
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. BP
GO:0031667 response to nutrient levels A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. BP
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. BP
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. BP
GO:0008258 head involution Movement of the anterior ectoderm to the interior of the embryo. BP
GO:0008257 protein histidine tele-kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine. MF
GO:0008256 protein histidine pros-kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine. MF
GO:0008255 ecdysis-triggering hormone activity NA MF
GO:0008254 3'-nucleotidase activity Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. MF
GO:0008253 5'-nucleotidase activity Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. MF
GO:0008252 nucleotidase activity Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. MF
GO:0008251 tRNA specific adenosine deaminase activity NA MF
GO:0008250 oligosaccharyl transferase complex A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast. CC
GO:0002888 positive regulation of myeloid leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. BP
GO:0002889 regulation of immunoglobulin mediated immune response Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response. BP
GO:0002880 regulation of chronic inflammatory response to non-antigenic stimulus Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. BP
GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. BP
GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus. BP
GO:0002883 regulation of hypersensitivity Any process that modulates the frequency, rate, or extent of hypersensitivity. BP
GO:0002884 negative regulation of hypersensitivity Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity. BP
GO:0002885 positive regulation of hypersensitivity Any process that activates or increases the frequency, rate, or extent of hypersensitivity. BP
GO:0002886 regulation of myeloid leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. BP
GO:0002887 negative regulation of myeloid leukocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. BP
GO:0031042 O-glycan processing, core 6 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-1->6-GalNAc. BP
GO:0009708 benzyl isoquinoline alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings. BP
GO:0009709 terpenoid indole alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate). BP
GO:0032368 regulation of lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells. BP
GO:0032369 negative regulation of lipid transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells. BP
GO:0032366 intracellular sterol transport The directed movement of sterols within cells. BP
GO:0009703 nitrate reductase (NADH) activity Catalysis of the reaction: NO2- (nitrite) + NAD+ + H2O = NO3- (nitrate) + NADH + H+. MF
GO:0009700 indole phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response. BP
GO:0032365 intracellular lipid transport The directed movement of lipids within cells. BP
GO:0009706 chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. CC
GO:0032363 FMN catabolic process The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. BP
GO:0009704 de-etiolation The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll. BP
GO:0009705 vacuolar membrane (sensu Magnoliophyta) The lipid bilayer enclosing the vacuole; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0046989 galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids. MF
GO:0046988 asioloorosomucoid beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid. MF
GO:0031041 O-glycan processing, core 5 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-1->3-GalNAc. BP
GO:0046981 beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids. MF
GO:0046980 tapasin binding Interacting selectively with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules. MF
GO:0046983 protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. MF
GO:0046982 protein heterodimerization activity Interacting selectively with a nonidentical protein to form a heterodimer. MF
GO:0046985 positive regulation of hemoglobin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. BP
GO:0046984 regulation of hemoglobin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. BP
GO:0046987 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine). MF
GO:0046986 negative regulation of hemoglobin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. BP
GO:0047816 D-arabinose 1-dehydrogenase activity Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH. MF
GO:0019958 C-X-C chemokine binding Interacting selectively with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. MF
GO:0019959 interleukin-8 binding Interacting selectively with interleukin-8. MF
GO:0019956 chemokine binding Interacting selectively with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. MF
GO:0019957 C-C chemokine binding Interacting selectively with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. MF
GO:0019954 asexual reproduction The biological process by which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process. BP
GO:0019955 cytokine binding Interacting selectively with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. MF
GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. BP
GO:0019950 SMT3-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein. BP
GO:0019951 Smt3-protein conjugation The covalent addition to a protein of Smt3, a ubiquitin-like protein. BP
GO:0032348 negative regulation of aldosterone biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. BP
GO:0030988 high molecular weight kininogen receptor complex A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins. CC
GO:0030989 horsetail nuclear movement The cell cycle process whereby oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, which may facilitate synapsis necessary for efficient meiotic recombination; as observed in S. pombe. BP
GO:0030984 kininogen binding Interacting selectively with a kininogen, any of a group of plasma proteins that are kinin precursors. MF
GO:0030985 high molecular weight kininogen binding Interacting selectively with a kininogen of high molecular mass. MF
GO:0030986 low molecular weight kininogen binding Interacting selectively with a kininogen of low molecular mass. MF
GO:0030987 high molecular weight kininogen receptor binding Interacting selectively with a high molecular weight kininogen receptor. MF
GO:0030980 alpha-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-glucans. BP
GO:0030981 cortical microtubule cytoskeleton The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane. CC
GO:0030982 adventurous gliding motility A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime. BP
GO:0030983 mismatched DNA binding Interacting selectively with double-stranded DNA containing one or more mismatches. MF
GO:0042196 chlorinated hydrocarbon metabolic process The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it. BP
GO:0042197 halogenated hydrocarbon metabolic process The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine. BP
GO:0042194 quinate biosynthetic process The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid. BP
GO:0042195 aerobic gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen. BP
GO:0042192 methylmercury biosynthetic process The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal. BP
GO:0042193 methylmercury catabolic process The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal. BP
GO:0042190 vanillin catabolic process The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods. BP
GO:0042191 methylmercury metabolic process The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species. BP
GO:0042198 nylon metabolic process The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. BP
GO:0042199 cyanuric acid metabolic process The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives. BP
GO:0042228 interleukin-8 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-8. BP
GO:0042229 interleukin-9 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-9. BP
GO:0047618 acylagmatine amidase activity Catalysis of the reaction: benzoylagmatine + H2O = benzoate + agmatine. MF
GO:0047619 acylcarnitine hydrolase activity Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine. MF
GO:0042220 response to cocaine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. BP
GO:0042221 response to chemical stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. BP
GO:0042222 interleukin-1 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen. BP
GO:0042223 interleukin-3 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-3. BP
GO:0047616 acyl-CoA dehydrogenase (NADP+) activity Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+. MF
GO:0042225 interleukin-5 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-5. BP
GO:0042226 interleukin-6 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-6. BP
GO:0042227 interleukin-7 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-7. BP
GO:0003708 retinoic acid receptor activity Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A. MF
GO:0003709 RNA polymerase III transcription factor activity Functions to initiate or regulate RNA polymerase III transcription. MF
GO:0006558 L-phenylalanine metabolic process The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid. BP
GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. BP
GO:0003700 transcription factor activity The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. MF
GO:0006557 S-adenosylmethioninamine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. BP
GO:0003702 RNA polymerase II transcription factor activity Functions to initiate or regulate RNA polymerase II transcription. MF
GO:0006555 methionine metabolic process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. BP
GO:0006552 leucine catabolic process The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid. BP
GO:0006553 lysine metabolic process The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. BP
GO:0003706 ligand-regulated transcription factor activity NA MF
GO:0006551 leucine metabolic process The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid. BP
GO:0000240 diplotene Progression through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. BP
GO:0000241 diakinesis Progression through the final stage of prophase I in meiosis; the transition to meiotic metaphase I. BP
GO:0000242 pericentriolar material A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. CC
GO:0000243 commitment complex The first portion of the spliceosome to assemble in mRNA splicing; in commitment complex formation the 5' and 3' splice sites are recognized by the U1 snRNP and the U2 snRNP auxiliary factor, respectively. CC
GO:0000244 assembly of spliceosomal tri-snRNP The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. BP
GO:0000245 spliceosome assembly The aggregation and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. BP
GO:0000246 delta24(24-1) sterol reductase activity Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH + H+. MF
GO:0000247 C-8 sterol isomerase activity Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. MF
GO:0000248 C-5 sterol desaturase activity Catalysis of the introduction of a C-5 double bond in the B ring of ergosterol. MF
GO:0000249 C-22 sterol desaturase activity Catalysis of the formation of the C-22(23) double bond in the sterol side chain. MF
GO:0004950 chemokine receptor activity Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity. MF
GO:0004951 cholecystokinin receptor activity Combining with cholecystokinin, a 33-amino acid peptide secreted by the upper intestinal mucosa and also found in the central nervous system, to initiate a change in cell activity. MF
GO:0004952 dopamine receptor activity Combining with the neurotransmitter dopamine to initiate a change in cell activity. MF
GO:0004953 icosanoid receptor activity Combining with an icosanoid to initiate a change in cell activity. MF
GO:0004954 prostanoid receptor activity Combining with a prostanoid, any compound based on or derive4d from the prostanoate structure, to initiate a change in cell activity. MF
GO:0004955 prostaglandin receptor activity Combining with a prostaglandin (PG) to initiate a change in cell activity. MF
GO:0004956 prostaglandin D receptor activity Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. MF
GO:0004957 prostaglandin E receptor activity Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. MF
GO:0004958 prostaglandin F receptor activity Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. MF
GO:0003711 transcriptional elongation regulator activity Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. MF
GO:0009298 GDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. BP
GO:0031595 nuclear proteasome complex A proteasome found in the nucleus of a cell. CC
GO:0002079 inner acrosomal membrane The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane. CC
GO:0002078 membrane fusion during acrosome reaction The fusion of the plasma membrane of the sperm with the outer acrosomal membrane. BP
GO:0002071 glandular epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. BP
GO:0002070 epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. BP
GO:0002073 retina development (sensu Mammalia) The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The process begins after the optic cup has reached its final shape as a two-layered structure and ends with a mature functional retina. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0002072 optic cup morphogenesis (sensu Mammalia) The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0002075 somitomeric trunk muscle development (sensu Mammalia) The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0002074 extraocular skeletal muscle development (sensu Mammalia) The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0002077 acrosome matrix dispersal The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg. BP
GO:0002076 osteoblast development The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. BP
GO:0051109 crotonobetaine-CoA ligase activity Catalysis of the reaction: CoA + crotono-betaine = crotonobetainyl-CoA. MF
GO:0051108 carnitine-CoA ligase activity Catalysis of the reaction: D-carnitine + CoA = D-carnitinyl-CoA. MF
GO:0051105 regulation of DNA ligation Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. BP
GO:0051104 DNA ligation during DNA-dependent DNA replication The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA-dependent DNA replication. BP
GO:0051107 negative regulation of DNA ligation Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. BP
GO:0051106 positive regulation of DNA ligation Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. BP
GO:0051101 regulation of DNA binding Any process that modulates the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid. BP
GO:0051100 negative regulation of binding Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. BP
GO:0051103 DNA ligation during DNA repair The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA repair. BP
GO:0051102 DNA ligation during DNA recombination The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA recombination. BP
GO:0010029 regulation of seed germination Any process that modulates the frequency, rate or extent of seed germination. BP
GO:0010028 xanthophyll cycle A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II. BP
GO:0010025 wax biosynthetic process The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids. BP
GO:0010024 phytochromobilin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha. BP
GO:0010027 thylakoid membrane organization and biogenesis The assembly and arrangement of the thylakoid membrane. BP
GO:0010026 trichome differentiation (sensu Magnoliophyta) The process whereby a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0010021 amylopectin biosynthetic process The chemical reactions and pathways resulting in the formation of amylopectin, the (1,4) linked alpha glucose units with alpha-(1,6) linkages. BP
GO:0010020 chloroplast fission The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis. BP
GO:0010023 proanthocyanidin biosynthetic process The chemical reactions and pathways resulting in the formation of proanthocyanidin. BP
GO:0010022 meristem determinacy The process by which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate). BP
GO:0018230 peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine to form peptidyl-S-palmitoyl-L-cysteine; the palmitate group represents a mixture of saturated and unsaturated fatty acids. BP
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine The co- or posttranslational modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids. BP
GO:0018232 peptide cross-linking via S-(L-isoglutamyl)-L-cysteine The posttranslation modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link. BP
GO:0018233 peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine The posttranslation modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link. BP
GO:0018234 peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine The posttranslational thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase. BP
GO:0018235 peptidyl-lysine carboxylation The posttranslational modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine. BP
GO:0018236 ribulose-bisphosphate carboxylase activase activity NA MF
GO:0018237 urease activase activity NA MF
GO:0018238 peptidyl-lysine carboxyethylation The posttranslational modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine. BP
GO:0018239 protein amino acid carboxyethylation The addition of a carboxyethyl group to a protein amino acid. BP
GO:0009295 nucleoid The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined. CC
GO:0005391 sodium:potassium-exchanging ATPase activity Catalysis of the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). MF
GO:0005395 eye pigment precursor transporter activity Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out). MF
GO:0004046 aminoacylase activity Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. MF
GO:0004047 aminomethyltransferase activity Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. MF
GO:0004044 amidophosphoribosyltransferase activity Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. MF
GO:0004045 aminoacyl-tRNA hydrolase activity Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. MF
GO:0004042 amino-acid N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. MF
GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. MF
GO:0004040 amidase activity Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. MF
GO:0004048 anthranilate phosphoribosyltransferase activity Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate. MF
GO:0004049 anthranilate synthase activity Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. MF
GO:0001678 cell glucose homeostasis Any of the processes involved in the maintenance of an internal equilibrium of glucose within a cell or between a cell and its external environment. BP
GO:0001676 long-chain fatty acid metabolic process The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18. BP
GO:0001677 formation of translation initiation ternary complex Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). BP
GO:0001674 female germ cell nucleus The nucleus of the female germ cell, a cell specialized to produce haploid gametes, and its descendents. CC
GO:0001675 acrosome formation The formation of the acrosome from the spermatid Golgi. BP
GO:0001672 regulation of chromatin assembly or disassembly Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly. BP
GO:0001673 male germ cell nucleus The nucleus of a male germ cell, a cell specialized to produce haploid gametes, and its descendents. CC
GO:0001670 dopamine D2 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors. MF
GO:0001671 ATPase stimulator activity Functions to increase the rate of ATP hydrolysis. MF
GO:0052456 modulation by organism of jasmonic acid levels in other organism during symbiotic interaction The alteration by an organism of the levels of jasmonic acid in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0018499 cis-2,3-dihydrodiol DDT dehydrogenase activity Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT. MF
GO:0018494 carvone reductase activity Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone. MF
GO:0018495 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA. MF
GO:0018496 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA. MF
GO:0052459 modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of programmed cell death by a non-apoptotic pathway in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0018490 4-hydroxyphenylpyruvate oxidase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + 1/2 O2 = 4-hydroxyphenylacetate + CO2. MF
GO:0018491 2-oxobutyrate synthase activity Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin. MF
GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor. MF
GO:0018493 formylmethanofuran dehydrogenase activity Catalysis of the reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor. MF
GO:0019541 propionate metabolic process The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants. BP
GO:0019540 siderophore biosynthetic process from catechol The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol. BP
GO:0019543 propionate catabolic process The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid. BP
GO:0019542 propionate biosynthetic process The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid. BP
GO:0019545 arginine catabolic process to succinate The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate. BP
GO:0019544 arginine catabolic process to glutamate The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate. BP
GO:0019547 arginine catabolic process to ornithine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine. BP
GO:0019546 arginine deiminase pathway NA BP
GO:0019549 glutamate catabolic process to succinate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including succinate. BP
GO:0019548 arginine catabolic process to spermine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine. BP
GO:0051116 cobaltochelatase activity Catalysis of the reaction: ATP + hydrogenobyrinic acid a,c-diamide + Co2+ = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H+. MF
GO:0051117 ATPase binding Interacting selectively with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. MF
GO:0051114 peptidyl-histidine uridylylation The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine). BP
GO:0004382 guanosine-diphosphatase activity Catalysis of the reaction: GDP + H2O = GMP + phosphate. MF
GO:0051112 peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine). BP
GO:0004386 helicase activity Catalysis of the unwinding of a DNA or RNA duplex. MF
GO:0051488 anaphase-promoting complex activation Any process that initiatiates the ubiquitin ligase activity of the anaphase-promoting complex. BP
GO:0051489 regulation of filopodium formation Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. BP
GO:0005801 Golgi cis face The convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. CC
GO:0051481 reduction of cytosolic calcium ion concentration Any process that decreases the concentration of calcium ions in the cytodol. BP
GO:0051482 elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger. BP
GO:0051483 terpenoid biosynthetic process, mevalonate-independent The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate. BP
GO:0051484 isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway during terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. BP
GO:0051485 terpenoid biosynthetic process, mevalonate-dependent The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, actetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. BP
GO:0051486 isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway during terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. BP
GO:0051487 anaphase-promoting complex activation during meiotic cell cycle Any process that initiatiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle. BP
GO:0007098 centrosome cycle The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. BP
GO:0007099 centriole replication The cell cycle process whereby a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. BP
GO:0007094 mitotic spindle checkpoint A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly). BP
GO:0007095 mitotic G2 checkpoint A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA. BP
GO:0007096 regulation of exit from mitosis Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. BP
GO:0007097 nuclear migration The directed movement of the nucleus. BP
GO:0007090 regulation of S phase of mitotic cell cycle A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of mitotic cell cycle. BP
GO:0007091 mitotic metaphase/anaphase transition The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins. BP
GO:0007092 anaphase-promoting complex activation during mitotic cell cycle Any process that activates, maintains or increases the rate of the ubiquitin ligase activity of the anaphase-promoting complex during the mitotic cell cycle. BP
GO:0007093 mitotic checkpoint A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis. BP
GO:0015879 carnitine transport The directed movement of carnitine into, out of, within or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. BP
GO:0015878 biotin transport The directed movement of biotin into, out of, within or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. BP
GO:0015874 norepinephrine transport The directed movement of norepinephrine into, out of, within or between cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. BP
GO:0015877 biopterin transport The directed movement of biopterin into, out of, within or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. BP
GO:0015876 acetyl-CoA transport The directed movement of acetyl-CoA into, out of, within or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. BP
GO:0015871 choline transport The directed movement of choline into, out of, within or between cells. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. BP
GO:0015870 acetylcholine transport The directed movement of acetylcholine into, out of, within or between cells. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. BP
GO:0015872 dopamine transport The directed movement of dopamine into, out of, within or between cells. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. BP
GO:0003812 alternative-complement-pathway C3/C5 convertase activity Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b. MF
GO:0048854 brain morphogenesis The process by which the anatomical structures of brain are generated and organized. Morphogenesis pertains to the creation of form. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). BP
GO:0048857 neural nucleus development The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. BP
GO:0008015 circulation The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products. BP
GO:0008017 microtubule binding Interacting selectively with microtubules, filaments composed of tubulin monomers. MF
GO:0008016 regulation of heart contraction Any process that modulates the frequency, rate or extent of heart contraction. BP
GO:0008011 structural constituent of pupal cuticle (sensu Insecta) The action of a molecule that contributes to the structural integrity of the cuticle of an pupa. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). MF
GO:0008010 structural constituent of larval cuticle (sensu Insecta) The action of a molecule that contributes to the structural integrity of the cuticle of a larva. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). MF
GO:0008013 beta-catenin binding Interacting selectively with the beta subunit of the catenin complex. MF
GO:0008012 structural constituent of adult cuticle (sensu Insecta) The action of a molecule that contributes to the structural integrity of the cuticle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). MF
GO:0014009 glial cell proliferation The multiplication or reproduction of glial cells by cell division, resulting in the rapid expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. BP
GO:0014008 positive regulation of microglia differentiation Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. BP
GO:0042476 odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). BP
GO:0014003 oligodendrocyte development The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. BP
GO:0014002 astrocyte development The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. BP
GO:0014001 sclerenchyma cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. Plant cell type with thick lignified walls, normally dead at maturity and specialised for structural strength. Includes fibre cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplast at maturity. Cell form and size are variable. BP
GO:0014007 negative regulation of microglia differentiation Any process that stops, prevents or reduces the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. BP
GO:0014006 regulation of microglia differentiation Any process that modulates the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. BP
GO:0014005 microglia development The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0014004 microglia differentiation The process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system. BP
GO:0051400 BH domain binding Interacting selectively with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. MF
GO:0051401 CH domain binding Interacting selectively with the calponin homology domain of a protein, a domain of 100 residues that occurs in signaling and cytoskeletal proteins. MF
GO:0051402 neuron apoptosis The process of apoptosis in neurons, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. BP
GO:0051403 stress-activated MAPK cascade A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. BP
GO:0042479 positive regulation of eye photoreceptor cell development Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. BP
GO:0051404 clostripain activity Catalysis of the cleavage of Arg-Xaa bonds. MF
GO:0051405 microbial collagenase activity Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds. MF
GO:0051406 beta-actinin binding Interacting selectively with beta-actinin, a heterodimeric actin-binding protein which caps the barbed end of actin filaments and nucleates actin polymerization in a calcium-independent manner. In myofibrils it is localized in the Z-lines. MF
GO:0051407 glycerone phosphate:inorganic phosphate antiporter activity Catalysis of the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out). MF
GO:0051408 glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity Catalysis of the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out). MF
GO:0048850 hypophysis morphogenesis The process by which the anatomical structures of the hypophysis are generated and organized. Morphogenesis pertains to the creation of form. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. BP
GO:0048852 diencephalon morphogenesis The process by which the anatomical structures of diencephalon are generated and organized. Morphogenesis pertains to the creation of form. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. BP
GO:0048797 swim bladder formation The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. BP
GO:0048794 swim bladder development The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. BP
GO:0048795 swim bladder morphogenesis The process by which the anatomical structure of the swim bladder is generated and organized. Morphogenesis pertains to the creation of form. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. BP
GO:0030653 beta-lactam antibiotic metabolic process The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. BP
GO:0016513 core-binding factor complex A heterodimer with alpha- and beta-subunits that binds the core site 5'-PYGPYGGT-3' of several enhancers and promoters; the beta-subunit enhances the DNA binding of the alpha-subunit. CC
GO:0016512 endothelin-converting enzyme 1 activity Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor. MF
GO:0016511 endothelin-converting enzyme activity NA MF
GO:0046509 1,2-diacylglycerol 3-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + 1,2-diacylglycerol = UDP + 3-beta-D-galactosyl-1,2-diacylglycerol. MF
GO:0016516 interleukin-4 receptor complex Complexes that bind interleukin-4; consist of alpha, beta, and gamma chains and exist in three forms, one containing extracellular transmembrane and cytoplasmic domains, one lacking the cytoplasmic domain and a third that is secreted. CC
GO:0016515 interleukin-13 receptor activity Combining with interleukin-13 to initiate a change in cell activity. MF
GO:0016514 SWI/SNF complex Any of a family of protein complexes that regulate transcription by remodeling chromatin. Swi/Snf complexes comprise nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. CC
GO:0046505 sulfolipid metabolic process The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid. BP
GO:0046504 glycerol ether biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. BP
GO:0046507 UDPsulfoquinovose synthase activity Catalysis of the reaction: UDP-glucose + SO3(2-) (sulfite) = UDP-6-sulfoquinovose + H2O. MF
GO:0016518 interleukin-14 receptor activity Combining with interleukin-14 to initiate a change in cell activity. MF
GO:0046501 protoporphyrinogen IX metabolic process The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation. BP
GO:0046500 S-adenosylmethionine metabolic process The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. BP
GO:0046503 glycerolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. BP
GO:0046502 uroporphyrinogen III metabolic process The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds. BP
GO:0045852 pH elevation Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. BP
GO:0045853 negative regulation of bicoid mRNA localization Any process that stops, prevents or reduces the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location. BP
GO:0045850 positive regulation of nurse cell apoptosis Any process that activates or increases the frequency, rate or extent of nurse cell apoptosis. BP
GO:0045851 pH reduction Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. BP
GO:0045856 positive regulation of pole plasm oskar mRNA localization Any process that activates or increases the frequency, rate or extent of the process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0045857 negative regulation of protein activity, epigenetic Any epigenetic process that stops, prevents or reduces the rate of protein activity. BP
GO:0045854 positive regulation of bicoid mRNA localization Any process that activates or increases the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location. BP
GO:0045855 negative regulation of pole plasm oskar mRNA localization Any process that stops, prevents or reduces the frequency, rate or extent of the processes by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0045858 positive regulation of protein activity, epigenetic Any epigenetic process that activates or increases the rate of protein activity. BP
GO:0045859 regulation of protein kinase activity Any process that modulates the frequency, rate or extent of protein kinase activity. BP
GO:0048793 pronephros development The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. The pronephros is the first of the embryonic kidneys to be established and is the simplest vertebrate excretory organ. BP
GO:0048790 maintenance of presynaptic active zone structure The process by which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters. BP
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter The release of a neurotransmitter into the synaptic cleft, where the release step is dependent on the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell. BP
GO:0031259 uropod membrane The portion of the plasma membrane surrounding a uropod. CC
GO:0031258 lamellipodium membrane The portion of the plasma membrane surrounding a lamellipodium. CC
GO:0031257 trailing edge membrane The portion of the plasma membrane surrounding the trailing edge of a motile cell. CC
GO:0031256 leading edge membrane The portion of the plasma membrane surrounding the leading edge of a motile cell. CC
GO:0031255 lateral part of motile cell The area of a motile cell perpendicular to the direction of movement. CC
GO:0031254 trailing edge The area of a motile cell opposite to the direction of movement. CC
GO:0031253 cell projection membrane The portion of the plasma membrane surrounding a cell surface projection. CC
GO:0031252 leading edge The area of a motile cell closest to the direction of movement. CC
GO:0031251 PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. CC
GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit. CC
GO:0048367 shoot development The process whose specific outcome is the progression of the shoot over time, from its formation to the mature structure. BP
GO:0048366 leaf development The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure. BP
GO:0048365 Rac GTPase binding Interacting selectively with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. MF
GO:0048364 root development The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. BP
GO:0048363 mucilage pectin metabolic process The chemical reactions and pathways involving the pectin component of mucilage. BP
GO:0048362 pedicel mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the flower stem. BP
GO:0048361 root epithelial mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. BP
GO:0048360 root cap mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth. BP
GO:0048369 lateral mesoderm morphogenesis The process by which the anatomical structures of the lateral mesoderm are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048368 lateral mesoderm development The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. BP
GO:0050537 mandelamide amidase activity Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH3. MF
GO:0050536 (S)-N-acetyl-1-phenylethylamine hydrolase activity Catalysis of the reaction: N-acetylphenylethylamine + H2O = phenylethylamine + acetate. MF
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. MF
GO:0050534 3-deoxyoctulosonase activity Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide. MF
GO:0009001 serine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + L-serine = CoA + O-acetyl-L-serine. MF
GO:0050532 2-phosphosulfolactate phosphatase activity Catalysis of the reaction: 2-phospho-3-sulfolactate + H2O = 3-sulfolactate + phosphate. MF
GO:0050531 mannosyl-3-phosphoglycerate phosphatase activity Catalysis of the reaction: 2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate. MF
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. MF
GO:0009009 site-specific recombinase activity Catalysis of new phosphodiester bonds between a pair of short, unique DNA target sequences. MF
GO:0009008 DNA-methyltransferase activity Catalysis of the transfer of a methyl group to a DNA molecule. MF
GO:0050539 maleimide hydrolase activity Catalysis of the reaction: maleimide + H2O = maleamic acid. MF
GO:0050538 N-carbamoyl-L-amino-acid hydrolase activity Catalysis of the reaction: N-carbamoyl-L-2-amino acid (a 2-ureido carboxylate) + H2O = L-2-amino acid + NH3 + CO2. MF
GO:0030708 female germ-line cyst encapsulation (sensu Insecta) Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030709 border follicle cell delamination The splitting off of border cells from the anterior epithelium, prior to border cell migration. BP
GO:0030702 chromatin silencing at centromere Repression of transcription of centromeric DNA by the formation of heterochromatin. BP
GO:0030703 eggshell formation Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration. BP
GO:0030700 glycine reductase complex Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C. CC
GO:0030701 NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]. MF
GO:0030706 oocyte differentiation (sensu Insecta) The process whereby one relatively unspecialized immature cystocyte of the germ-line cyst acquires the specialized features of an oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030707 ovarian follicle cell development (sensu Insecta) The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030704 vitelline membrane formation Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg. BP
GO:0030705 cytoskeleton-dependent intracellular transport The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell. BP
GO:0043663 host bacteroid-containing symbiosome A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell. CC
GO:0043662 peribacteroid fluid The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome. CC
GO:0043660 bacteroid-containing symbiosome A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants. CC
GO:0043667 pollen wall The complex wall surrounding a pollen grain. CC
GO:0043666 regulation of phosphoprotein phosphatase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. BP
GO:0043665 host peribacteroid fluid The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell. CC
GO:0043664 host peribacteroid membrane A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). CC
GO:0043669 ectexine The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections. CC
GO:0032285 ensheathment of non-myelinated axons The process by which a non-myelinating glial cell membrane closes around an axon. BP
GO:0032284 plastid biotin carboxylase complex A biotin carboxylase complex located in the stroma of a plastid. CC
GO:0032287 myelin maintenance in the peripheral nervous system The process by which the structure and material content of mature peripheral nervous system myelin is kept in a functional state. BP
GO:0032286 myelin maintenance in the central nervous system The process by which the structure and material content of mature central nervous system myelin is kept in a functional state. BP
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the centre of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. CC
GO:0032280 symmetric synapse A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density. CC
GO:0032283 plastid acetate CoA-transferase complex An acetate CoA-transferase complex located in the stroma of a plastid. CC
GO:0032282 plastid acetyl-CoA carboxylase complex An acetyl-CoA carboxylase complex located in the stroma of a plastid. CC
GO:0032289 myelin formation in the central nervous system The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system. BP
GO:0032288 myelin formation The process by which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. BP
GO:0018964 propylene metabolic process The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals. BP
GO:0018965 s-triazine compound metabolic process The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. BP
GO:0008358 maternal determination of anterior/posterior axis, embryo The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos. BP
GO:0008359 regulation of bicoid mRNA localization Any process that modulates the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location. BP
GO:0018960 4-nitrophenol metabolic process The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. BP
GO:0018961 pentachlorophenol metabolic process The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms. BP
GO:0018962 3-phenylpropionate metabolic process The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins. BP
GO:0018963 phthalate metabolic process The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses. BP
GO:0008352 katanin complex A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa). CC
GO:0008353 RNA polymerase subunit kinase activity Catalysis of the reaction: ATP + (DNA-directed RNA polymerase) = ADP + phospho-(DNA-directed RNA polymerase). MF
GO:0018968 tetrahydrofuran metabolic process The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems. BP
GO:0018969 thiocyanate metabolic process The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries. BP
GO:0008354 germ cell migration The orderly movement of a germ cell, a cell specialized to produce haploid gametes, through the embryo from its site of production to the place where the gonads will form. BP
GO:0008355 olfactory learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. BP
GO:0040011 locomotion Self-propelled movement of a cell or organism from one location to another. BP
GO:0040010 positive regulation of growth rate Any process that increases the rate of growth of all or part of an organism. BP
GO:0040013 negative regulation of locomotion Any process that stops, prevents or reduces the frequency, rate or extent of locomotion of a cell or organism. BP
GO:0040012 regulation of locomotion Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. BP
GO:0040015 negative regulation of body size Any process that stops, prevents or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. BP
GO:0040014 regulation of body size Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. BP
GO:0040017 positive regulation of locomotion Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. BP
GO:0040016 embryonic cleavage The first few specialized divisions of an activated animal egg. BP
GO:0040019 positive regulation of embryonic development Any process that activates or increases the frequency, rate or extent of embryonic development. BP
GO:0040018 positive regulation of body size Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. BP
GO:0032139 dinucleotide insertion or deletion binding Interacting selectively with double-stranded DNA containing a dinucleotide insertion or deletion. MF
GO:0032138 single base insertion or deletion binding Interacting selectively with double-stranded DNA containing a single base insertion or deletion. MF
GO:0032137 guanine/thymine mispair binding Interacting selectively with double-stranded DNA containing an G/T mispair. MF
GO:0032136 adenine/cytosine mispair binding Interacting selectively with double-stranded DNA containing an A/C mispair. MF
GO:0032135 DNA insertion or deletion binding Interacting selectively with double-stranded DNA containing insertions or deletions. MF
GO:0032134 mispaired DNA binding Interacting selectively with double-stranded DNA containing pyrimidine/purine mispairs. MF
GO:0032133 chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger comples coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain containing protein survivin, aurora kinase and INCENP. CC
GO:0032132 O6-alkylguanine-DNA binding Interacting selectively with O6-alkylguanine adducts in DNA. MF
GO:0032131 alkylated DNA binding Interacting selectively with alkylated residues in DNA. MF
GO:0032130 medial membrane band formation The formation of sterol rich region of the plasma membrane at the cell surface overlying the contractile ring. BP
GO:0017074 procollagen N-endopeptidase activity Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln. MF
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. BP
GO:0006294 nucleotide-excision repair, preincision complex formation The assembly of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. BP
GO:0006297 nucleotide-excision repair, DNA gap filling Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. BP
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage. BP
GO:0006290 pyrimidine dimer repair The repair of UV-induced T-T, C-T and C-C dimers. BP
GO:0006293 nucleotide-excision repair, preincision complex stabilization The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. BP
GO:0006298 mismatch repair A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. BP
GO:0005928 apical hemi-adherens junction An adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle. CC
GO:0005929 cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. CC
GO:0005926 connecting hemi-adherens junction A hemiadherens junction (HAJ) that forms juctions such that HAJs in opposing cells are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects). CC
GO:0005927 muscle tendon junction An adherens junctions formed between a muscle cell and a tendon cell; the muscle and tendon cytoplasmic faces are distinct. CC
GO:0005924 cell-substrate adherens junction An adherens junction which connects a cell to the extracellular matrix. CC
GO:0005925 focal adhesion Small region on the surface of a cell that anchors the cell to the extracellular matrix and that are points of termination of actin filaments. CC
GO:0005922 connexon complex An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. CC
GO:0005923 tight junction A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia. CC
GO:0005920 smooth septate junction A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions. CC
GO:0005921 gap junction Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. CC
GO:0045505 dynein intermediate chain binding Interacting selectively with an intermediate chain of the dynein complex. MF
GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. BP
GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. BP
GO:0006748 lipoamide metabolic process The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group. BP
GO:0006747 FAD biosynthetic process The chemical reactions and pathways resulting in the formation of FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. BP
GO:0006746 FADH2 metabolic process The chemical reactions and pathways involving the reduced form of flavin-adenine dinucleotide. BP
GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. BP
GO:0006743 ubiquinone metabolic process The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. BP
GO:0006742 NADP catabolic process The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. BP
GO:0006741 NADP biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH. BP
GO:0006740 NADPH regeneration NA BP
GO:0048608 reproductive structure development The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. BP
GO:0005219 ryanodine-sensitive calcium-release channel activity NA MF
GO:0048604 fibroblast growth factor 3 binding Interacting selectively with fibroblast growth factor 3. MF
GO:0048605 fibroblast growth factor 4 binding Interacting selectively with fibroblast growth factor 4. MF
GO:0048606 fibroblast growth factor 5 binding Interacting selectively with fibroblast growth factor 5. MF
GO:0048607 fibroblast growth factor 6 binding Interacting selectively with fibroblast growth factor 6. MF
GO:0048600 oocyte fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oocyte. BP
GO:0048601 oocyte morphogenesis The process by which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. BP
GO:0005212 structural constituent of eye lens The action of a molecule that contributes to the structural integrity of the lens of an eye. MF
GO:0005213 structural constituent of chorion (sensu Insecta) The action of a molecule that contributes to the structural integrity of a chorion. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). MF
GO:0015220 choline transporter activity Enables the directed movement of choline into, out of, within or between cells. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. MF
GO:0015221 lipopolysaccharide transporter activity Enables the directed movement of lipopolysaccharides into, out of, within or between cells. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. MF
GO:0007504 larval fat body development The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life. BP
GO:0007505 adult fat body development The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body. BP
GO:0007502 gut mesoderm development The process whose specific outcome is the progression of the gut mesoderm over time, from its formation to the mature structure. The gut mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gut of the organism. BP
GO:0015225 biotin transporter activity Enables the directed movement of biotin into, out of, within or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. MF
GO:0007500 mesodermal cell fate determination Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0007501 mesodermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0015228 coenzyme A transporter activity Enables the directed movement of coenzyme A into, out of, within or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. MF
GO:0015229 L-ascorbic acid transporter activity Enables the directed movement of L-ascorbate into, out of, within or between cells. L-ascorbate is a six-carbon carbohydrate-like compound found in fruit and vegetables. It has vitamin C activity in humans and guinea pigs. MF
GO:0007508 larval heart development The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper. BP
GO:0007509 mesoderm migration The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism. BP
GO:0019736 peptidyl-sarcosine incorporation The incorporation of sarcosine (N-methylglycine) into non-coded peptides. BP
GO:0019734 antifungal humoral response (sensu Vertebrata) An immune response against a fungus mediated through a body fluid, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0019735 antimicrobial humoral response (sensu Vertebrata) An immune response against microbes mediated through a body fluid, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0019732 antifungal humoral response An immune response against a fungus mediated through a body fluid. BP
GO:0019733 antibacterial humoral response (sensu Vertebrata) An immune response against bacteria mediated through a body fluid, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0019730 antimicrobial humoral response An immune response against microbes mediated through a body fluid. BP
GO:0019731 antibacterial humoral response An immune response against bacteria mediated through a body fluid. BP
GO:0001829 trophectodermal cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. BP
GO:0001828 inner cell mass cellular morphogenesis The morphogenesis of cells in the inner cell mass. BP
GO:0001827 inner cell mass cell fate commitment The cell fate commitment of precursor cells that will become inner cell mass cells. BP
GO:0001826 inner cell mass cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an inner cell mass cell. BP
GO:0001825 blastocyst formation The initial formation of a blastocyst from a solid ball of cells known as a morula. BP
GO:0001824 blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. BP
GO:0001823 mesonephros development The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is a transient excretory organ of the embryo. BP
GO:0001822 kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. BP
GO:0001821 histamine secretion The regulated release of histamine by a cell or group of cells. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems. BP
GO:0001820 serotonin secretion The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. BP
GO:0016751 S-succinyltransferase activity Catalysis of the transfer of an succinyl group to a sulfur atom on the acceptor molecule. MF
GO:0016750 O-succinyltransferase activity Catalysis of the transfer of an succinyl group to an oxygen atom on the acceptor molecule. MF
GO:0016753 O-sinapoyltransferase activity Catalysis of the transfer of an sinapoyl group to an oxygen atom on the acceptor molecule. MF
GO:0016752 sinapoyltransferase activity Catalysis of the transfer of an sinapoyl group to an acceptor molecule. MF
GO:0016755 transferase activity, transferring amino-acyl groups Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). MF
GO:0016754 sinapoylglucose-malate O-sinapoyltransferase activity Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + (S)-malate = D-glucose + sinapoyl-(S)-malate. MF
GO:0016757 transferase activity, transferring glycosyl groups Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). MF
GO:0016756 glutathione gamma-glutamylcysteinyltransferase activity Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly. MF
GO:0016759 cellulose synthase activity Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1). MF
GO:0016758 transferase activity, transferring hexosyl groups Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). MF
GO:0021687 cerebellar molecular layer morphogenesis The process by which the anatomical structure of the cerebellar molecular layer is generated and organized. Morphogenesis pertains to the creation of form. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. BP
GO:0021686 cerebellar granular layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. BP
GO:0021681 cerebellar granular layer development The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. BP
GO:0021680 cerebellar Purkinje cell layer development The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. BP
GO:0021683 cerebellar granular layer morphogenesis The process by which the anatomical structure of the cerebellar granular layer is generated and organized. Morphogenesis pertains to the creation of form. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. BP
GO:0021682 nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. BP
GO:0016289 CoA hydrolase activity Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. MF
GO:0016283 eukaryotic 48S initiation complex The 48S initiation complex is composed of the 40S ribosomal subunit, the initiator tRNA, and the mRNA. CC
GO:0016282 eukaryotic 43S preinitiation complex The 43S preinitiation complex is the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound to the initiator tRNA. CC
GO:0016281 eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. CC
GO:0016287 glycerone-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate. MF
GO:0016286 small conductance calcium-activated potassium channel activity NA MF
GO:0016285 cytosol alanyl aminopeptidase activity Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides. MF
GO:0016284 alanine aminopeptidase activity Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide. MF
GO:0012501 programmed cell death Cell death resulting from activation of endogenous cellular processes. BP
GO:0012502 induction of programmed cell death A process which directly activates any of the steps required for programmed cell death. BP
GO:0012503 induction of non-apoptotic programmed cell death A process which directly activates any of the steps required for non-apoptotic programmed cell death. BP
GO:0012504 induction of non-apoptotic programmed cell death by other organism A process which directly activates any of the steps required for non-apoptotic programmed cell death in another organism. BP
GO:0012505 endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. CC
GO:0012506 vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell. CC
GO:0012507 ER to Golgi transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. CC
GO:0012508 Golgi to ER transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER. CC
GO:0012509 inter-Golgi transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances within the Golgi. CC
GO:0031019 mitochondrial mRNA editing complex An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates. CC
GO:0031018 endocrine pancreas development The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. BP
GO:0031015 karyopherin docking complex A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p. CC
GO:0031014 troponin T binding Interacting selectively with troponin T, the tropomyosin-binding subunit of the troponin complex. MF
GO:0031017 exocrine pancreas development The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. BP
GO:0031016 pancreas development The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. BP
GO:0031011 INO80 complex A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity. CC
GO:0031010 ISWI complex Any chromatin remodeling complex that contains an ATPase subunit of the ISWI family. CC
GO:0031013 troponin I binding Interacting selectively with troponin I, the inhibitory subunit of the troponin complex. MF
GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). CC
GO:0051699 proline oxidase activity Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2. MF
GO:0017159 pantetheinase activity NA MF
GO:0051691 cellular oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. BP
GO:0051690 organismal oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level. BP
GO:0051693 actin filament capping The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. BP
GO:0051692 cellular oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. BP
GO:0017154 semaphorin receptor activity NA MF
GO:0051694 pointed-end actin filament capping The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. BP
GO:0051697 protein delipidation The breakage of covalent or non-covalent bonds to detach lipid moieties from a protein. BP
GO:0051696 pointed-end actin filament uncapping The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. BP
GO:0009249 protein-lipoylation NA BP
GO:0009248 K antigen biosynthetic process The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. BP
GO:0009243 O antigen biosynthetic process The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. BP
GO:0009242 colanic acid biosynthetic process The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide. BP
GO:0009241 polyisoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of polyisoprenoids, acyclic polymers containing a large number of isoprene subunits, usually unsaturated. BP
GO:0009240 isopentenyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. BP
GO:0009247 glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. BP
GO:0009246 enterobacterial common antigen biosynthetic process The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. BP
GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. BP
GO:0009244 lipopolysaccharide core region biosynthetic process The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. BP
GO:0008198 ferrous iron binding Interacting selectively with ferrous iron, Fe(II). MF
GO:0008199 ferric iron binding Interacting selectively with ferric iron, Fe(III). MF
GO:0008190 eukaryotic initiation factor 4E binding Interacting selectively with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. MF
GO:0008191 metalloendopeptidase inhibitor activity Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity. MF
GO:0008192 RNA guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. MF
GO:0008193 tRNA guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. MF
GO:0008194 UDP-glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. MF
GO:0008195 phosphatidate phosphatase activity Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. MF
GO:0008196 vitellogenin receptor activity Combining with vitellogenin to initiate a change in cell activity. MF
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. CC
GO:0045260 proton-transporting ATP synthase complex (sensu Bacteria) The complex that catalyzes the phosphorylation of ADP to ATP in the plasma membrane, during oxidative phosphorylation; it catalyzes the hydrolysis of ATP to ADP and orthophosphate. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. CC
GO:0045262 proton-transporting ATP synthase complex, catalytic core F(1) (sensu Bacteria) The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045265 proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core. CC
GO:0045264 proton-transporting ATP synthase complex, coupling factor F(o) (sensu Bacteria) All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045267 proton-transporting ATP synthase, catalytic core The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. CC
GO:0045266 proton-transporting ATP synthase, stator stalk (sensu Bacteria) One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045269 proton-transporting ATP synthase, central stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis. CC
GO:0045268 proton-transporting ATP synthase, catalytic core (sensu Bacteria) The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0051215 DNA virus induced gene silencing Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing. BP
GO:0051214 RNA virus induced gene silencing Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing. BP
GO:0015529 raffinose:hydrogen symporter activity Catalysis of the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in). MF
GO:0015528 lactose:hydrogen symporter activity Catalysis of the reaction: lactose(out) + H+(out) = lactose(in) + H+(in). MF
GO:0032739 positive regulation of interleukin-16 production Any process that activates or increases the frequency, rate, or extent of interleukin-16 production. BP
GO:0032738 positive regulation of interleukin-15 production Any process that activates or increases the frequency, rate, or extent of interleukin-15 production. BP
GO:0015522 hydrophobic uncoupler:hydrogen antiporter activity Catalysis of the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS. MF
GO:0032735 positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. BP
GO:0032734 positive regulation of interleukin-11 production Any process that activates or increases the frequency, rate, or extent of interleukin-11 production. BP
GO:0032737 positive regulation of interleukin-14 production Any process that activates or increases the frequency, rate, or extent of interleukin-14 production. BP
GO:0032736 positive regulation of interleukin-13 production Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. BP
GO:0032731 positive regulation of interleukin-1 beta production Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. BP
GO:0032730 positive regulation of interleukin-1 alpha production Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production. BP
GO:0032733 positive regulation of interleukin-10 production Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. BP
GO:0032732 positive regulation of interleukin-1 production Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. BP
GO:0015520 tetracycline:hydrogen antiporter activity Catalysis of the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). MF
GO:0007205 protein kinase C activation The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. BP
GO:0007204 elevation of cytosolic calcium ion concentration Any process that increases the concentration of calcium ions in the cytosol. BP
GO:0015149 hexose transporter activity Enables the directed movement of a hexose sugar, a monosaccharide with 6 carbon atoms, into, out of, within or between cells. MF
GO:0015148 D-xylose transporter activity Enables the directed movement of D-xylose into, out of, within or between cells. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. MF
GO:0015141 succinate transporter activity Enables the directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of, within or between cells. MF
GO:0015140 malate transporter activity Enables the directed movement of malate into, out of, within or between cells. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. MF
GO:0015143 urate transporter activity Enables the directed movement of urate into, out of, within or between cells. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. MF
GO:0015142 tricarboxylic acid transporter activity Enables the directed movement of tricarboxylic acids into, out of, within or between cells. Tricarboxylic acid are organic acids with three COOH groups. MF
GO:0015145 monosaccharide transporter activity Enables the directed movement of monosaccharide into, out of, within or between cells. MF
GO:0015144 carbohydrate transporter activity Enables the directed movement of carbohydrate into, out of, within or between cells. MF
GO:0015147 L-arabinose transporter activity Enables the directed movement of L-arabinose into, out of, within or between cells. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc. MF
GO:0015146 pentose transporter activity Enables the directed movement of a pentose sugar, a monosaccharide with 5 carbon atoms, into, out of, within or between cells. MF
GO:0001694 histamine biosynthetic process The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. BP
GO:0001695 histamine catabolic process The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. BP
GO:0050691 regulation of antiviral response by host Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. BP
GO:0001696 gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. BP
GO:0001697 histamine-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP. BP
GO:0001691 pseudophosphatase activity Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues. MF
GO:0001692 histamine metabolic process The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. BP
GO:0019659 glucose catabolic process to lactate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP). BP
GO:0019658 glucose catabolic process to lactate and acetate The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP. BP
GO:0002620 negative regulation of non-professional antigen presenting cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. BP
GO:0002621 positive regulation of non-professional antigen presenting cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. BP
GO:0002622 regulation of B cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation. BP
GO:0002623 negative regulation of B cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation. BP
GO:0002624 positive regulation of B cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation. BP
GO:0002625 regulation of T cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. BP
GO:0002626 negative regulation of T cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. BP
GO:0002627 positive regulation of T cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. BP
GO:0002628 regulation of proteolysis associated with antigen processing and presentation Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. BP
GO:0002629 negative regulation of proteolysis associated with antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. BP
GO:0005607 laminin-2 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma1. CC
GO:0035039 male pronucleus formation The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division. BP
GO:0035038 female pronucleus formation Formation of the haploid nucleus of the unfertilized egg. BP
GO:0005606 laminin-1 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha1, beta1 and gamma1. CC
GO:0035033 histone deacetylase regulator activity Modulates the activity of histone deacetylase. MF
GO:0035032 phosphoinositide 3-kinase complex, class III A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). CC
GO:0035031 phosphoinositide 3-kinase complex, class IB A complex containing a heterodimer of a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks. CC
GO:0035030 phosphoinositide 3-kinase complex, class IA A complex containing a heterodimer of a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit bound to a SH2 domain-containing regulatory (adaptor) subunit. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. CC
GO:0035037 sperm entry Penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur. BP
GO:0035036 sperm-egg recognition The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. BP
GO:0035035 histone acetyltransferase binding Interacting selectively with the enzyme histone acetyltransferase. MF
GO:0035034 histone acetyltransferase regulator activity Modulates the activity of histone acetyltransferase. MF
GO:0030005 di-, tri-valent inorganic cation homeostasis The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic cations within a cell or between a cell and its external environment. BP
GO:0030004 monovalent inorganic cation homeostasis The regulation of the levels, transport, and metabolism of monovalent inorganic cations within a cell or between a cell and its external environment. BP
GO:0030007 potassium ion homeostasis The regulation of the levels, transport, and metabolism of potassium ions within a cell or between a cell and its external environment. BP
GO:0002652 regulation of tolerance induction dependent upon immune response Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response. BP
GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells. BP
GO:0030003 cation homeostasis The regulation of the levels, transport, and metabolism of cations within a cell or between a cell and its external environment. BP
GO:0030002 anion homeostasis The regulation of the levels, transport, and metabolism of anions within a cell or between a cell and its external environment. BP
GO:0005603 complement component C2 complex NA CC
GO:0030008 TRAPP complex A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion. CC
GO:0005602 complement component C1q complex NA CC
GO:0005601 classical-complement-pathway C3/C5 convertase complex NA CC
GO:0002656 negative regulation of tolerance induction to nonself antigen Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen. BP
GO:0043379 memory T cell differentiation The process whereby a newly activated T cell acquires specialized features of a memory T cell. BP
GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation. BP
GO:0043371 negative regulation of CD4-positive, alpha beta T cell differentiation Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation. BP
GO:0043370 regulation of CD4-positive, alpha beta T cell differentiation Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation. BP
GO:0043373 CD4-positive, alpha-beta T cell lineage commitment The process by which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell. BP
GO:0043372 positive regulation of CD4-positive, alpha beta T cell differentiation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha beta T cell differentiation. BP
GO:0043375 CD8-positive, alpha-beta T cell lineage commitment The process by which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell. BP
GO:0043374 CD8-positive, alpha-beta T cell differentiation The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell. BP
GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation. BP
GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation. BP
GO:0048442 sepal development The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure. BP
GO:0048443 stamen development The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure. BP
GO:0048440 carpel development The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style. BP
GO:0048441 petal development The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure. BP
GO:0048446 petal morphogenesis The process by which the anatomical structures of the petal are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048447 sepal morphogenesis The process by which the anatomical structures of the sepal are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048444 floral organ morphogenesis The process by which the anatomical structures of the floral organ are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048445 carpel morphogenesis The process by which the anatomical structures of the carpel are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048448 stamen morphogenesis The process by which the anatomical structures of the stamen are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048449 floral organ formation The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0004507 steroid 11-beta-monooxygenase activity Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. MF
GO:0004506 squalene monooxygenase activity Catalysis of the formation of a 2,3-epoxide in squalene. MF
GO:0004505 phenylalanine 4-monooxygenase activity Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. MF
GO:0004504 peptidylglycine monooxygenase activity Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. MF
GO:0004503 monophenol monooxygenase activity Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O. MF
GO:0004502 kynurenine 3-monooxygenase activity Catalysis of the reaction: L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O. MF
GO:0004501 ecdysone 20-monooxygenase activity Catalysis of the reaction: ecdysone + donor-H2 + O2 = 20-hydroxyecdysone + acceptor + H2O. MF
GO:0004500 dopamine beta-monooxygenase activity Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O. MF
GO:0004509 steroid 21-monooxygenase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O. MF
GO:0004508 steroid 17-alpha-monooxygenase activity Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. MF
GO:0009904 chloroplast accumulation movement The relocation process by which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis. BP
GO:0009905 ent-copalyl diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = ent-copalyl diphosphate. MF
GO:0009906 response to photoperiod, blue light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light (light with a wavelength of between 440 and 500nm) photoperiod stimulus. BP
GO:0009907 response to photoperiod, red light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light (light with a wavelength of between 620 and 700nm) photoperiod stimulus. BP
GO:0009900 dehiscence The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it. BP
GO:0009901 anther dehiscence The dehiscence of an anther to release the pollen grains contained within it. BP
GO:0009902 chloroplast relocation The process by which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery. BP
GO:0009903 chloroplast avoidance movement The relocation process by which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery. BP
GO:0009908 flower development The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. BP
GO:0009909 regulation of flower development Any process that modulates the frequency, rate or extent of flower development. BP
GO:0048194 Golgi vesicle budding The evagination of the Golgi membrane, resulting in formation of a vesicle. BP
GO:0048195 Golgi membrane priming complex assembly A process by which an incoming coat component recognizes both GTPase and a membrane protein to form the membrane priming complex. BP
GO:0048196 extracellular matrix (sensu Magnoliophyta) The matrix external to the cell, composed of the cell wall and middle lamella. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0048197 Golgi membrane coat protein complex assembly The process by which priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat. BP
GO:0048190 wing disc dorsal/ventral pattern formation The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing. BP
GO:0048193 Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. BP
GO:0048198 Golgi vesicle bud deformation and release The process by which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released. BP
GO:0048199 vesicle targeting, to, from or within Golgi The process by which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. BP
GO:0031358 intrinsic to chloroplast outer membrane Located in the chloroplast outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031359 integral to chloroplast outer membrane Penetrating at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0042778 tRNA end turnover Process by which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA. BP
GO:0042779 removal of tRNA 3'-trailer sequence Endonucleolytic or exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. BP
GO:0042776 ATP synthesis coupled proton transport (sensu Eukaryota) The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). BP
GO:0042777 ATP synthesis coupled proton transport (sensu Bacteria) The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0042774 ATP synthesis coupled electron transport (sensu Bacteria) The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0042775 ATP synthesis coupled electron transport (sensu Eukaryota) The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). BP
GO:0042772 DNA damage response, signal transduction resulting in transcription A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. BP
GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. BP
GO:0042770 DNA damage response, signal transduction A cascade of processes induced by the detection of DNA damage within a cell. BP
GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death). BP
GO:0050472 zeatin reductase activity Catalysis of the reaction: dihydrozeatin + NADP+ = zeatin + NADPH. MF
GO:0050473 arachidonate 15-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. MF
GO:0050470 trimethylamine dehydrogenase activity Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein. MF
GO:0050471 uracilylalanine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate. MF
GO:0050476 acetylenedicarboxylate decarboxylase activity Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate. MF
GO:0050477 acyl-lysine deacylase activity Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate. MF
GO:0050474 (S)-norcoclaurine synthase activity Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O. MF
GO:0050475 (S)-norlaudanosoline synthase activity Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)ethylamine + 3,4-dihydroxyphenylacetaldehyde = (S)-norlaudanosoline + H2O. MF
GO:0050478 anthranilate 3-monooxygenase activity Catalysis of the reaction: O2 + anthranilate + (tetrahydrobiopterin/tetrahydropteridine) = 3-hydroxanthranilate + H2O + (dihydrobiopterin/dihydropteridine). MF
GO:0050479 glyceryl-ether monooxygenase activity Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). MF
GO:0030058 amine dehydrogenase activity Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor. MF
GO:0030059 aralkylamine dehydrogenase activity Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor; acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine. MF
GO:0003999 adenine phosphoribosyltransferase activity Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0003998 acylphosphatase activity Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. MF
GO:0003995 acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. MF
GO:0003994 aconitate hydratase activity Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. MF
GO:0003997 acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. MF
GO:0003996 acyl-CoA ligase activity NA MF
GO:0003991 acetylglutamate kinase activity Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. MF
GO:0003990 acetylcholinesterase activity Catalysis of the reaction: acetylcholine + H2O = choline + acetate. MF
GO:0003993 acid phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate. MF
GO:0003992 acetylornithine transaminase activity Catalysis of the reaction: N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. MF
GO:0002381 immunoglobulin production during immune response The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002387 immune response in gut-associated lymphoid tissue Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules. BP
GO:0002386 immune response in mucosal-associated lymphoid tissue Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes. BP
GO:0002385 mucosal immune response An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. BP
GO:0002384 hepatic immune response An immune response taking place in the liver. BP
GO:0032078 negative regulation of endodeoxyribonuclease activity Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. BP
GO:0032079 positive regulation of endodeoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. BP
GO:0032072 regulation of restriction endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. BP
GO:0032073 negative regulation of restriction endodeoxyribonuclease activity Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. BP
GO:0032070 regulation of deoxyribonuclease activity Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. BP
GO:0032071 regulation of endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. BP
GO:0032076 negative regulation of deoxyribonuclease activity Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. BP
GO:0032077 positive regulation of deoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. BP
GO:0032074 negative regulation of nuclease activity Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. BP
GO:0032075 positive regulation of nuclease activity Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. BP
GO:0019248 D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde The chemical reactions and pathways resulting in the formation of D-lactate from other compounds, including methylglyoxal, via the intermediate (R)-lactaldehyde. BP
GO:0019249 lactate biosynthetic process The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid. BP
GO:0019246 L(+)-lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of L(+)lactate from other compounds, including pyruvate. BP
GO:0019247 lactate racemization Partial conversion of one lactate enantiomorph into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture. BP
GO:0019244 lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate. BP
GO:0019245 D(-)-lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate. BP
GO:0019242 methylglyoxal biosynthetic process The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. BP
GO:0019243 methylglyoxal catabolic process to D-lactate The breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. BP
GO:0019240 citrulline biosynthetic process The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. BP
GO:0019241 citrulline catabolic process The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. BP
GO:0019869 chloride channel inhibitor activity NA MF
GO:0019862 IgA binding Interacting selectively with an immunoglobulin of an IgA isotype. MF
GO:0019863 IgE binding Interacting selectively with an immunoglobulin of the IgE isotype. MF
GO:0019860 uracil metabolic process The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. BP
GO:0019861 flagellum Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium. CC
GO:0019866 organelle inner membrane The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. CC
GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. CC
GO:0019864 IgG binding Interacting selectively with an immunoglobulin of an IgG isotype. MF
GO:0019865 immunoglobulin binding Interacting selectively with an immunoglobulin. MF
GO:0060028 convergent extension involved in axis elongation The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism. BP
GO:0060029 convergent extension involved in organogenesis The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ. BP
GO:0060026 convergent extension The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. BP
GO:0060027 convergent extension involved in gastrulation The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. BP
GO:0060024 rhythmic synaptic transmission Processes involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit. BP
GO:0060025 regulation of synaptic activity Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell. BP
GO:0060022 hard palate development The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes. BP
GO:0060023 soft palate development The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate. BP
GO:0060020 Bergmann glial cell differentiation The process whereby neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0060021 palate development The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. BP
GO:0006468 protein amino acid phosphorylation The process of introducing a phosphoric group on to a protein. BP
GO:0006469 negative regulation of protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity. BP
GO:0006463 steroid hormone receptor complex assembly The aggregation and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. BP
GO:0006461 protein complex assembly The aggregation and bonding together of a set of components to form a protein complex. BP
GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. BP
GO:0006464 protein modification The covalent alteration of one or more amino acid residues within a protein, resulting in a change in the properties of that protein. BP
GO:0006465 signal peptide processing NA BP
GO:0051057 positive regulation of small GTPase mediated signal transduction Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. BP
GO:0000158 protein phosphatase type 2A activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. A protein serine/threonine phosphatase that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine. MF
GO:0000159 protein phosphatase type 2A complex A heterodimer with protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic and regulatory subunits. CC
GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within rRNA, resulting in a change in the properties of the rRNA. BP
GO:0000155 two-component sensor activity Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. MF
GO:0000156 two-component response regulator activity Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. MF
GO:0000150 recombinase activity Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. MF
GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex. CC
GO:0000152 nuclear ubiquitin ligase complex A ubiquitin ligase complex found in the nucleus. CC
GO:0000153 cytoplasmic ubiquitin ligase complex A ubiquitin ligase complex found in the cytoplasm. CC
GO:0018388 N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine. BP
GO:0018389 N-terminal peptidyl-valine deamination The deamination of valine to form isobutyrate. BP
GO:0018386 N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine. BP
GO:0018387 N-terminal peptidyl-amino acid deamination to pyruvic acid The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. BP
GO:0018656 phenanthrene 3,4-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide. MF
GO:0018657 toluene 3-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene. MF
GO:0018654 2-hydroxy-phenylacetate hydroxylase activity Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate. MF
GO:0018655 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA. MF
GO:0018652 toluene-sulfonate methyl-monooxygenase activity Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol. MF
GO:0018653 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. MF
GO:0018650 styrene monooxygenase activity Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide. MF
GO:0018651 toluene-4-sulfonate monooxygenase activity Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene. MF
GO:0018658 salicylate 1-monooxygenase activity Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2. MF
GO:0018659 4-hydroxybenzoate 3-monooxygenase activity Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O. MF
GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity Catalysis of the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in). MF
GO:0015388 potassium uptake permease activity Catalysis of the reaction: K+(out) + energy = K+(in). MF
GO:0015387 potassium:hydrogen symporter activity Catalysis of the reaction: K+(out) + H+(out) = K+(in) + H+(in). MF
GO:0015386 potassium:hydrogen antiporter activity Catalysis of the reaction: K+(in) + H+(out) = K+(out) + H+(in). MF
GO:0015385 sodium:hydrogen antiporter activity Catalysis of the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). MF
GO:0015383 sulfate:bicarbonate antiporter activity Catalysis of the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out). MF
GO:0015382 sodium:sulfate symporter activity Catalysis of the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in). MF
GO:0015381 high affinity sulfate permease activity NA MF
GO:0015380 anion exchanger activity NA MF
GO:0051523 cell growth mode switching, monopolar to bipolar The process by which a cell switches from monopolar cell growth to bipolar cell growth. BP
GO:0051522 activation of monopolar cell growth Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell. BP
GO:0051521 termination of monopolar cell growth Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell. BP
GO:0051520 termination of bipolar cell growth Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell. BP
GO:0051527 NFAT2 protein binding Interacting selectively with NFAT2 (nuclear factor of activated T cells 2 protein), a calcium-regulated protein which acts as a transcription factor. MF
GO:0051526 NFAT1 protein binding Interacting selectively with NFAT1 (nuclear factor of activated T cells 1 protein), a calcium-regulated protein which acts as a transcription factor. MF
GO:0051525 NFAT protein binding Interacting selectively with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. MF
GO:0051524 cell growth mode switch, bipolar to monopolar The process by which a cell switches from bipolar cell growth to monopolar cell growth. BP
GO:0051529 NFAT4 protein binding Interacting selectively with NFAT4 (nuclear factor of activated T cells 4 protein), a calcium-regulated protein which acts as a transcription factor. MF
GO:0051528 NFAT3 protein binding Interacting selectively with NFAT3 (nuclear factor of activated T cells 3 protein), a calcium-regulated protein which acts as a transcription factor. MF
GO:0001788 antibody-dependent cellular cytotoxicity Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. BP
GO:0001789 G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) A G-protein coupled signaling pathway that results in the activation of sphingosine kinase, causing an increase in cellular levels of sphingosine-1-phosphate. BP
GO:0001782 B cell homeostasis The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. BP
GO:0001783 B cell apoptosis The process of apoptosis in B cells. BP
GO:0001780 neutrophil homeostasis The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. BP
GO:0001781 neutrophil apoptosis The process of apoptosis in neutrophils. BP
GO:0001786 phosphatidylserine binding Interacting selectively with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. MF
GO:0001787 natural killer cell proliferation The rapid expansion of a natural killer cell population by cell division. BP
GO:0001784 phosphotyrosine binding Interacting selectively with a phosphorylated tyrosine residue within a protein. MF
GO:0001785 prostaglandin J receptor activity Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. MF
GO:0016126 sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. BP
GO:0016127 sterol catabolic process The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. BP
GO:0016124 xanthophyll catabolic process The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids. BP
GO:0016125 sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. BP
GO:0016122 xanthophyll metabolic process The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids. BP
GO:0016123 xanthophyll biosynthetic process The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids. BP
GO:0016120 carotene biosynthetic process The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids. BP
GO:0016121 carotene catabolic process The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids. BP
GO:0016128 phytosteroid metabolic process The chemical reactions and pathways involving phytosteroids, steroids of higher plants differing from animal steroids C1 or C2 residues at C24 and/or a double bond at C22. BP
GO:0016129 phytosteroid biosynthetic process The chemical reactions and pathways resulting in the formation of phytosteroids, steroids of higher plants differing from animal steroids in having substitutions at C24 and/or a double bond at C22. BP
GO:0030249 guanylate cyclase regulator activity Modulates the activity of guanylate cyclase. MF
GO:0030248 cellulose binding Interacting selectively with cellulose. MF
GO:0030243 cellulose metabolic process The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. BP
GO:0030242 peroxisome degradation The process by which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions. BP
GO:0030241 muscle thick filament assembly Formation of the myosin-based thick filaments of myofibrils. BP
GO:0030240 muscle thin filament assembly Formation of the actin-based thin filaments of myofibrils. BP
GO:0030247 polysaccharide binding Interacting selectively with any polysaccharide. MF
GO:0030246 carbohydrate binding Interacting selectively with any carbohydrate. MF
GO:0030245 cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. BP
GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. BP
GO:0002101 tRNA wobble cytosine modification The process whereby a cytosine in position 34 of a tRNA is post-transcriptionally modified. BP
GO:0015646 permease activity Catalysis of the stereospecific transfer of a substrate across a biological membrane. MF
GO:0015647 peptidoglycan transporter activity Enables the directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of, within or between cells. MF
GO:0031198 siderophore biosynthetic process from hydroxamic acid, peptide modification The covalent alteration of one or more amino acid residues within a hydroxamic acid-derived siderophore. BP
GO:0031199 ferrichrome biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of a ferrichrome, a type of siderophore. BP
GO:0015645 fatty-acid ligase activity Catalysis of the ligation of a long-chain carboxylic acid to an acceptor, coupled to the hydrolysis of ATP. MF
GO:0031190 siderophore biosynthetic process from catechol, peptide modification The covalent alteration of one or more amino acid residues within a catechol-derived siderophore. BP
GO:0031191 enterobactin biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore enterobactin. BP
GO:0031192 enterobactin biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within the siderophore enterobactin during the chemical reactions and pathways resulting in the formation of enterobactin. BP
GO:0031193 rhizobactin 1021 biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore rhizobactin. BP
GO:0031194 rhizobactin 1021 biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within the siderophore rhizobactin during the chemical reactions and pathways resulting in the formation of rhizobactin. BP
GO:0031195 vibriobactin biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore vibriobactin. BP
GO:0031196 vibriobactin biosynthetic process, peptide modification The covalent alteration of one or more amino acid residues within the siderophore vibriobactin during the chemical reactions and pathways resulting in the formation of vibriobactin. BP
GO:0031197 siderophore biosynthetic process from hydroxamic acid, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of a hydroxamic acid-derived siderophore. BP
GO:0047456 2-methylisocitrate dehydratase activity Catalysis of the reaction: methylisocitrate = H2O + 2-methylaconitate. MF
GO:0016599 caveolar membrane The membrane area of caveolae, the small pits, depressions, or invaginations found in the plasma membrane of cells. Caveolar membrane is characterized by the presence of caveolins, which constitute the major protein component of caveolar membrane in vivo. CC
GO:0043523 regulation of neuron apoptosis Any process that modulates the occurrence or rate of cell death by apoptosis in neurons. BP
GO:0043528 tRNA (m2G10) methyltransferase complex A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p. CC
GO:0043529 GET complex A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins. CC
GO:0002800 regulation of antifungal peptide secretion Any process that modulates the frequency, rate, or extent of . BP
GO:0002801 negative regulation of antifungal peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of . BP
GO:0002802 positive regulation of antifungal peptide secretion Any process that activates or increases the frequency, rate, or extent of . BP
GO:0002803 positive regulation of antibacterial peptide production Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production. BP
GO:0002804 positive regulation of antifungal peptide production Any process that activates or increases the frequency, rate, or extent of antifungal peptide production. BP
GO:0002805 regulation of antimicrobial peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis. BP
GO:0002806 negative regulation of antimicrobial peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis. BP
GO:0002807 positive regulation of antimicrobial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis. BP
GO:0002808 regulation of antibacterial peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis. BP
GO:0002809 negative regulation of antibacterial peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis. BP
GO:0009782 photosystem I antenna complex The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). CC
GO:0009783 photosystem II antenna complex The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). CC
GO:0009780 photosynthetic NADP+ reduction Processes by which NADP+ is reduced to NADPH. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions. BP
GO:0009781 photosynthetic water oxidation Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle. BP
GO:0009786 regulation of asymmetric cell division Any process that modulates the frequency, rate or extent of asymmetric cell division. BP
GO:0009787 regulation of abscisic acid mediated signaling Any process that modulates the frequency, rate or extent of signal transduction mediated by abscisic acid. BP
GO:0009784 transmembrane receptor histidine kinase activity A transmembrane receptor that perceives a stimulus and that produces a molecular signal via phosphotransfer at histidine residues. MF
GO:0009785 blue light signaling pathway The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 440nm and 500nm. BP
GO:0009788 negative regulation of abscisic acid mediated signaling Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by abscisic acid. BP
GO:0009789 positive regulation of abscisic acid mediated signaling Any process that activates or increases the frequency, rate or extent of abscisic acid mediated signal transduction. BP
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. BP
GO:0046900 tetrahydrofolylpolyglutamate metabolic process The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. BP
GO:0046903 secretion The regulated release of a substance by a cell or group of cells. BP
GO:0046902 regulation of mitochondrial membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. BP
GO:0046905 phytoene synthase activity Catalysis of the reaction: prephytoene pyrophosphate = phytoene + pyrophosphate. MF
GO:0046904 calcium oxalate binding Interacting selectively with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi. MF
GO:0046907 intracellular transport The directed movement of substances within a cell. BP
GO:0046906 tetrapyrrole binding Interacting selectively with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. MF
GO:0046909 intermembrane transport The directed movement of substances between the intracellular membranes of a cell, for example, the transfer of glycolipids from the endoplasmic reticulum to other cellular membrane structures in which they reside. BP
GO:0008789 altronate dehydratase activity Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O. MF
GO:0008788 alpha,alpha-phosphotrehalase activity Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate. MF
GO:0008781 N-acylneuraminate cytidylyltransferase activity Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. MF
GO:0008780 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. MF
GO:0008783 agmatinase activity Catalysis of the reaction: agmatine + H2O = putrescine + urea. MF
GO:0008782 adenosylhomocysteine nucleosidase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine. MF
GO:0008785 alkyl hydroperoxide reductase activity Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. MF
GO:0008784 alanine racemase activity Catalysis of the reaction: L-alanine = D-alanine. MF
GO:0008787 allose kinase activity Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate. MF
GO:0008786 allose 6-phosphate isomerase activity Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate. MF
GO:0032502 developmental process A biological process whose specific outcome is the progression of an integrated living unit: a cell, tissue, organ, or organism over time from an initial condition to a later condition. BP
GO:0032500 muramyl dipeptide binding Interacting selectively, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan. MF
GO:0032501 multicellular organismal process The biological processes, occurring at the level of the organism, pertinent to the function of the organism. BP
GO:0032506 cytokinetic process A cellular process that is involved in the division of the cytoplasm of a cell and its separation into two daughter cells. BP
GO:0032507 maintenance of cellular protein localization The processes by which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. BP
GO:0032504 multicellular organism reproduction The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. BP
GO:0032505 reproduction of a single-celled organism The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. BP
GO:0032508 DNA duplex unwinding The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. BP
GO:0008432 JUN kinase binding Interacting selectively with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. MF
GO:0008431 vitamin E binding Interacting selectively with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. MF
GO:0008430 selenium binding Interacting selectively with selenium (Se). MF
GO:0008437 thyrotropin-releasing hormone activity NA MF
GO:0008434 vitamin D3 receptor activity Combining with vitamin D3, cholecalciferol, to initiate a change in cell activity. MF
GO:0008439 monophenol monooxygenase activator activity Increases the activity of the enzyme monophenol monooxygenase. MF
GO:0042118 endothelial cell activation The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0042119 neutrophil activation The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0042116 macrophage activation A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0042117 monocyte activation The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0042113 B cell activation The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. BP
GO:0042110 T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. BP
GO:0045768 positive regulation of anti-apoptosis Any process that activates or increases the frequency, rate or extent of anti-apoptosis. BP
GO:0045769 negative regulation of asymmetric cell division Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric cell division. BP
GO:0045760 positive regulation of action potential Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. BP
GO:0045761 regulation of adenylate cyclase activity Any process that modulates the frequency, rate or extent of adenylate cyclase activity. BP
GO:0045762 positive regulation of adenylate cyclase activity Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. BP
GO:0045763 negative regulation of amino acid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. BP
GO:0045764 positive regulation of amino acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. BP
GO:0045765 regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis. BP
GO:0045766 positive regulation of angiogenesis Any process that activates or increases angiogenesis. BP
GO:0045767 regulation of anti-apoptosis Any process that modulates the frequency, rate or extent of anti-apoptosis. BP
GO:0047692 ATP deaminase activity Catalysis of the reaction: ATP + H2O = ITP + NH3. MF
GO:0047693 ATP diphosphatase activity Catalysis of the reaction: ATP + H2O = AMP + diphosphate. MF
GO:0047690 aspartyltransferase activity Catalysis of the reaction: L-asparagine + hydroxylamine = NH3 + L-aspartylhydroxamate. MF
GO:0047691 aspulvinone dimethylallyltransferase activity Catalysis of the reaction: 2 dimethylallyl diphosphate + aspulvinone E = 2 diphosphate + aspulvinone H. MF
GO:0047696 beta-adrenergic receptor kinase activity Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor. MF
GO:0047697 beta-alanopine dehydrogenase activity Catalysis of the reaction: beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH. MF
GO:0047694 barbiturase activity Catalysis of the reaction: barbiturate + H2O = malonate + urea. MF
GO:0047695 benzoin aldolase activity Catalysis of the reaction: benzoin = 2 benzaldehyde. MF
GO:0047698 beta-alanyl-CoA ammonia-lyase activity Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3. MF
GO:0047699 beta-diketone hydrolase activity Catalysis of the reaction: nonane-4,6-dione + H2O = pentan-2-one + butanoate. MF
GO:0003785 actin monomer binding Interacting selectively with monomeric actin, also known as G-actin. MF
GO:0003786 actin lateral binding Interacting selectively with an actin filament along its length. MF
GO:0030904 retromer complex A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. CC
GO:0030905 retromer complex, outer shell One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. CC
GO:0030906 retromer complex, inner shell One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p. CC
GO:0030907 MBF transcription complex A complex of two or three proteins that binds to the Mlu1 cell cycle box (MCB) promoter element and is involved in cell cycle-dependent regulation of transcription. In Saccharomyces the complex consists of Mbp1p and Swi6p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p. CC
GO:0030900 forebrain development The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). BP
GO:0030901 midbrain development The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). BP
GO:0030902 hindbrain development The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). BP
GO:0030903 notochord development The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. BP
GO:0030908 protein splicing The post-translational removal of peptide sequences from within a protein sequence. BP
GO:0030909 non-intein-mediated protein splicing The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins. BP
GO:0050924 positive regulation of negative chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. BP
GO:0050925 negative regulation of negative chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. BP
GO:0050926 regulation of positive chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. BP
GO:0050927 positive regulation of positive chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. BP
GO:0050920 regulation of chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. BP
GO:0050921 positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. BP
GO:0050922 negative regulation of chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. BP
GO:0050923 regulation of negative chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. BP
GO:0050928 negative regulation of positive chemotaxis Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. BP
GO:0050929 induction of negative chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. BP
GO:0002789 negative regulation of antifungal peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production. BP
GO:0002788 regulation of antifungal peptide production Any process that modulates the frequency, rate, or extent of antifungal peptide production. BP
GO:0002787 negative regulation of antibacterial peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production. BP
GO:0002786 regulation of antibacterial peptide production Any process that modulates the frequency, rate, or extent of antibacterial peptide production. BP
GO:0002785 negative regulation of antimicrobial peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production. BP
GO:0002784 regulation of antimicrobial peptide production Any process that modulates the frequency, rate, or extent of antimicrobial peptide production. BP
GO:0002783 antifungal peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antifungal peptide. BP
GO:0002782 antifungal peptide secretion The regulated release of an antifungal peptide from a cell or group of cells. BP
GO:0002781 antifungal peptide production The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels. BP
GO:0002780 antibacterial peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antibacterial peptide. BP
GO:0044419 interspecies interaction between organisms The processes by which an organism has an observable effect on an organism of a different species. BP
GO:0044418 translocation of DNA into host The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044411 entry into host through host barriers Penetration by an organism into its host organism via active breaching of the physical barriers of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044410 entry into host through natural portals Penetration by an organism into its host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044413 avoidance of host defenses Any process, either constitutive or induced, by which an organism evades, suppresses or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044412 growth or development of symbiont within host The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044415 evasion or tolerance of host defenses Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044414 suppression of host defenses Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044417 translocation of molecules into host The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044416 induction by symbiont of host defense response The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0019824 P6 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes. CC
GO:0046123 purine deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046122 purine deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046121 deoxyribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046120 deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046127 pyrimidine deoxyribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046126 pyrimidine deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046125 pyrimidine deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046124 purine deoxyribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0046129 purine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0046128 purine ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0048877 homeostasis of number of retinal cells The biological processes involved in the maintenance of the equilibrium of cell number within a population of cells in the retina. BP
GO:0005066 transmembrane receptor protein tyrosine kinase signaling protein activity NA MF
GO:0048875 chemical homeostasis within a tissue The processes involved in the maintenance of the internal equilibrium of the amount of a chemical at the level of the tissue. BP
GO:0048874 homeostasis of number of cells in a free-living population The biological process involved in maintaining the equilibrium of cell number within a population of free-living cells suc as the bacteria in the gut. BP
GO:0048873 homeostasis of number of cells within a tissue The biological processes involved in the maintenance of the equilibrium of cell number within a population of cells in a tissue. BP
GO:0005062 hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity NA MF
GO:0005061 aryl hydrocarbon receptor nuclear translocator activity NA MF
GO:0048870 cell motility involved in cell locomotion Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another. BP
GO:0005069 transmembrane receptor protein tyrosine kinase docking protein activity NA MF
GO:0048878 chemical homeostasis The biological processes involved in the maintenance of an internal equilibrium of a chemical. BP
GO:0002424 T cell mediated immune response to tumor cell An immune response mediated by a T cell triggered in response to the presence of a tumor cell. BP
GO:0002425 tolerance induction in urogenital tract Tolerance induction taking place in the urogenital tract. BP
GO:0048252 lauric acid metabolic process The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources. BP
GO:0048251 elastic fiber assembly Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. BP
GO:0048250 mitochondrial iron ion transport The directed movement of iron ions into, out of or within a mitochondrion. BP
GO:0048257 3'-flap endonuclease activity Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. MF
GO:0048256 flap endonuclease activity Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. MF
GO:0048255 mRNA stabilization Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. BP
GO:0048254 snoRNA localization The processes by which small nucleolar RNA is transported to, or maintained in, a specific location. BP
GO:0048259 regulation of receptor mediated endocytosis Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. BP
GO:0048258 3-ketoglucose-reductase activity Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose. MF
GO:0004334 fumarylacetoacetase activity Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. MF
GO:0004335 galactokinase activity Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. MF
GO:0004336 galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. MF
GO:0004337 geranyltranstransferase activity Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. MF
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. MF
GO:0004332 fructose-bisphosphate aldolase activity Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. MF
GO:0004333 fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H2O. MF
GO:0004338 glucan 1,3-beta-glucosidase activity Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose. MF
GO:0004339 glucan 1,4-alpha-glucosidase activity Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. MF
GO:0003818 complement factor I activity Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage. MF
GO:0018415 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. BP
GO:0018416 nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. BP
GO:0018417 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. BP
GO:0018410 peptide or protein carboxyl-terminal blocking NA BP
GO:0018411 protein amino acid glucuronidation The modification of a protein by amino acid glucuronidation. BP
GO:0018412 protein amino acid O-glucuronidation NA BP
GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. BP
GO:0008842 diphosphate-purine nucleoside kinase activity Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide. MF
GO:0008843 endochitinase activity Catalysis of the hydrolysis of nonterminal 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin and chitodextrins. MF
GO:0006864 pyrimidine nucleotide transport The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. BP
GO:0008841 dihydrofolate synthase activity Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate. MF
GO:0006862 nucleotide transport The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. BP
GO:0006863 purine transport The directed movement of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells. BP
GO:0006860 extracellular amino acid transport The directed extracellular movement of amino acids. BP
GO:0003817 complement factor D activity Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF). MF
GO:0042929 ferrichrome transporter activity Enables the directed movement of a ferrichrome into, out of, within or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. MF
GO:0042928 ferrichrome transport The directed movement of a ferrichrome into, out of, within or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. BP
GO:0042927 siderophore transporter activity Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of, within or between cells. MF
GO:0042926 3-hydroxyphenylpropionic acid transporter activity Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of, within or between cells. MF
GO:0042925 benzoate transporter activity Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of, within or between cells. MF
GO:0042924 neuromedin U binding Interacting selectively and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. MF
GO:0042923 neuropeptide binding Interacting selectively and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). MF
GO:0042922 neuromedin U receptor binding Interacting selectively with one or more specific sites on a neuromedin U receptor. MF
GO:0042921 glucocorticoid receptor signaling pathway Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor. BP
GO:0042920 3-hydroxyphenylpropionic acid transport The directed movement of 3-hydroxyphenylpropionic acid into, out of, within or between cells. BP
GO:0050333 thiamin-triphosphatase activity Catalysis of the reaction: thiamin triphosphate + H2O = thiamin diphosphate + phosphate. MF
GO:0018549 methanethiol oxidase activity Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2. MF
GO:0018547 nitroglycerin reductase activity Catalysis of the removal of one or more nitrite (NO2(-)) groups from nitroglycerin or a derivative. MF
GO:0018542 2,3-dihydroxy DDT 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate. MF
GO:0018543 4-amino-2-nitroso-6-nitrotoluene reductase activity Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene. MF
GO:0050155 ornithine(lysine) transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate. MF
GO:0050154 opheline kinase activity Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = ADP + N'-phosphoguanidinoethyl methylphosphate. MF
GO:0050157 ornithine racemase activity Catalysis of the reaction: L-ornithine = D-ornithine. MF
GO:0050156 ornithine N-benzoyltransferase activity Catalysis of the reaction: 2 benzoyl-CoA + L-ornithine = 2 CoA + N2,N5-dibenzoyl-L-ornithine. MF
GO:0050151 oleate hydratase activity Catalysis of the reaction: (R)-10-hydroxystearate = oleate + H2O. MF
GO:0050150 o-pyrocatechuate decarboxylase activity Catalysis of the reaction: 2,3-dihydroxybenzoate = catechol + CO2. MF
GO:0050153 omega-hydroxydecanoate dehydrogenase activity Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + NADH. MF
GO:0050152 omega-amidase activity Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. MF
GO:0050159 orsellinate decarboxylase activity Catalysis of the reaction: 2,4-dihydroxy-6-methylbenzoate = orcinol + CO2. MF
GO:0050158 orotate reductase (NADPH) activity Catalysis of the reaction: (S)-dihydroorotate + NADP+ = orotate + NADPH. MF
GO:0005881 cytoplasmic microtubule Any microtubule in the cytoplasm of a cell. CC
GO:0005880 nuclear microtubule Any microtubule in the nucleus of a cell. CC
GO:0005883 neurofilament A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. CC
GO:0005882 intermediate filament A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells. CC
GO:0005885 Arp2/3 protein complex A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. CC
GO:0005884 actin filament A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. CC
GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. CC
GO:0005889 hydrogen:potassium-exchanging ATPase complex NA CC
GO:0051409 response to nitrosative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. BP
GO:0007014 indirect flight muscle actin ubiquitination NA BP
GO:0007015 actin filament organization Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. BP
GO:0007016 cytoskeletal anchoring Process by which cytoskeletal filaments are directly or indirectly linked to the plasma membrane. BP
GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. BP
GO:0007010 cytoskeleton organization and biogenesis The assembly and arrangement of cytoskeletal structures. BP
GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. BP
GO:0007019 microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a microtubule. BP
GO:0051040 regulation of calcium-independent cell-cell adhesion Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. BP
GO:0051041 positive regulation of calcium-independent cell-cell adhesion Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion. BP
GO:0051042 negative regulation of calcium-independent cell-cell adhesion Any process that stops, prevents or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion. BP
GO:0051043 regulation of membrane protein ectodomain proteolysis Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). BP
GO:0004254 acylaminoacyl-peptidase activity Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide. MF
GO:0052171 growth or development during symbiotic interaction The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. BP
GO:0052170 negative regulation by symbiont of host innate immunity Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052173 response to defenses of other organism during symbiotic interaction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052172 metabolism by symbiont of host cell wall cellulose The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052175 metabolism by symbiont of host carbohydrate The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052174 metabolism by symbiont of host macromolecule The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052177 metabolism by symbiont of host xylan The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052176 metabolism by symbiont of host glucan The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052179 metabolism by symbiont of host cell wall pectin The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052178 metabolism by symbiont of host cell wall chitin The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0006059 hexitol metabolic process The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule. BP
GO:0006058 mannoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid. BP
GO:0006057 mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid. BP
GO:0006056 mannoprotein metabolic process The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid. BP
GO:0006055 CMP-N-acetylneuraminate biosynthetic process The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate. BP
GO:0006054 N-acetylneuraminate metabolic process The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. BP
GO:0006053 N-acetylmannosamine catabolic process The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. BP
GO:0006052 N-acetylmannosamine biosynthetic process The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. BP
GO:0006051 N-acetylmannosamine metabolic process The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose. BP
GO:0006050 mannosamine metabolic process The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins. BP
GO:0010263 tricyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings. BP
GO:0010262 somatic embryogenesis Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes. BP
GO:0010261 organ senescence (sensu Magnoliophyta) The process that occurs in a plant organ near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0010260 organ senescence The process that occurs in an organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. BP
GO:0010267 RNA interference, production of ta-siRNAs Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs. BP
GO:0010266 response to vitamin B1 A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus. BP
GO:0010265 SCF complex assembly The aggregation and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex. BP
GO:0010264 phytate biosynthetic process The chemical reactions and pathways resulting in the formation of phytic acid, phytate/hexakisphosphate inositol, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds. BP
GO:0010269 response to selenium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. BP
GO:0010268 brassinosteroid homeostasis Any of the processes involved in the maintenance of an internal equilibrium of brassinosteroids within an organism or cell. BP
GO:0018358 protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine. BP
GO:0005509 calcium ion binding Interacting selectively with calcium ions (Ca2+). MF
GO:0005504 fatty acid binding Interacting selectively with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. MF
GO:0005506 iron ion binding Interacting selectively with iron (Fe) ions. MF
GO:0005507 copper ion binding Interacting selectively with copper (Cu) ions. MF
GO:0005500 juvenile hormone binding Interacting selectively with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. MF
GO:0005501 retinoid binding Interacting selectively with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. MF
GO:0005502 11-cis retinal binding Interacting selectively with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. MF
GO:0005503 all-trans retinal binding Interacting selectively with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. MF
GO:0047450 crotonoyl-[acyl-carrier-protein] hydratase activity Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]. MF
GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]. MF
GO:0047452 protoaphin-aglucone dehydratase (cyclizing) activity Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin. MF
GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity Catalysis of the reaction: (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide + ATP = phosphate + NADH + ADP. MF
GO:0047454 phaseollidin hydratase activity Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin. MF
GO:0047455 16-alpha-hydroxyprogesterone dehydratase activity Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone. MF
GO:0015640 peptidoglycan peptide transporter activity Enables the directed movement of peptidoglycan peptides into, out of, within or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. MF
GO:0047457 exo-(1,4)-alpha-D-glucan lyase activity Catalysis of the reaction: linear alpha-glucan = 1,5-anhydro-D-fructose + beta-D-glucose. MF
GO:0047458 beta-pyrazolylalanine synthase activity Catalysis of the reaction: pyrazole + O-acetyl-L-serine = acetate + 3-(pyrazol-1-yl)-L-alanine. MF
GO:0047459 3-aminobutyryl-CoA ammonia-lyase activity Catalysis of the reaction: L-3-aminobutyryl-CoA = NH3 + crotonyl-CoA. MF
GO:0015648 lipid-linked peptidoglycan transporter activity NA MF
GO:0015649 2-keto-3-deoxygluconate:hydrogen symporter activity Catalysis of the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in). MF
GO:0043520 regulation of myosin II filament assembly Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules. BP
GO:0043521 regulation of myosin II filament disassembly Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules. BP
GO:0043522 leucine zipper domain binding Interacting selectively with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. MF
GO:0016598 protein arginylation The posttranslational conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. BP
GO:0043524 negative regulation of neuron apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis in neurons. BP
GO:0043525 positive regulation of neuron apoptosis Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptosis. BP
GO:0043526 neuroprotection Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss. BP
GO:0043527 tRNA methyltransferase complex A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. CC
GO:0016593 Cdc73/Paf1 complex A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Hpr1p, Ccr4p, Ctr9p, Rtf1p, and Leo1p. CC
GO:0016592 Srb-mediator complex A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. CC
GO:0016591 DNA-directed RNA polymerase II, holoenzyme Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. CC
GO:0016590 ACF complex A chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. In Drosophila, the complex comprises ACF1 and ISWI. CC
GO:0016597 amino acid binding Interacting selectively with an amino acid, organic acids containing one or more amino substituents. MF
GO:0016596 thienylcyclohexylpiperidine binding Interacting selectively with thienylcyclohexylpiperidine. MF
GO:0016595 glutamate binding Interacting selectively with glutamate, the anion of 2-aminopentanedioic acid. MF
GO:0016594 glycine binding Interacting selectively with glycine, aminoethanoic acid. MF
GO:0021739 mesencephalic trigeminal nucleus development The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure. BP
GO:0021738 fastigial nucleus development The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure. BP
GO:0021731 trigeminal motor nucleus development The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure. BP
GO:0021730 trigeminal sensory nucleus development The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure. BP
GO:0021733 caudal lateral line nerve development The progression of the caudal lateral line nerve over time from its initial formation until its mature state. The caudal lateral line nerve is a sensory afferent projecting from the posterior lateral line ganglion to the hindbrain in fishes. BP
GO:0021732 midbrain-hindbrain boundary maturation A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. BP
GO:0021735 dentate nucleus development The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure. BP
GO:0021734 rostral lateral line nerve development The progression of the rostral lateral line nerve over time from its initial formation until its mature state. The rostral lateral line nerve is a sensory afferent projecting from the anterior lateral line ganglion to the hindbrain in fishes. BP
GO:0021737 emboliform nucleus development The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure. BP
GO:0021736 globose nucleus development The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure. BP
GO:0042062 long-term strengthening of neuromuscular junction Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse. BP
GO:0046321 positive regulation of fatty acid oxidation Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. BP
GO:0046320 regulation of fatty acid oxidation Any process that modulates the frequency, rate or extent of fatty acid oxidation. BP
GO:0046323 glucose import The directed movement of the hexose monosaccharide glucose into a cell or organelle. BP
GO:0046322 negative regulation of fatty acid oxidation Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid oxidation. BP
GO:0046325 negative regulation of glucose import Any process that stops, prevents or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. BP
GO:0046324 regulation of glucose import Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. BP
GO:0046327 glycerol biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate. BP
GO:0046326 positive regulation of glucose import Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. BP
GO:0046329 negative regulation of JNK cascade Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. BP
GO:0046328 regulation of JNK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. BP
GO:0030782 (S)-tetrahydroprotoberberine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine. MF
GO:0030783 [cytochrome c]-methionine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine. MF
GO:0030780 12-hydroxydihydrochelirubine 12-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine. MF
GO:0030781 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline. MF
GO:0030786 (RS)-norcoclaurine 6-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine. MF
GO:0030787 inositol 4-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 4-methyl-myo-inositol. MF
GO:0030784 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline. MF
GO:0030785 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine. MF
GO:0030788 precorrin-2 C20-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A. MF
GO:0030789 precorrin-3B C17-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4. MF
GO:0045148 tripeptide aminopeptidase activity Catalysis of the release of the N-terminal residue from a tripeptide. MF
GO:0045149 acetoin metabolic process The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source. BP
GO:0045140 inositol phosphoceramide synthase activity Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide. MF
GO:0045141 telomere clustering The cell cycle process whereby the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis. BP
GO:0045142 triplex DNA binding Interacting selectively with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination. MF
GO:0045143 homologous chromosome segregation The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. BP
GO:0045144 meiotic sister chromatid segregation The cell cycle process whereby sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle. BP
GO:0045145 single-stranded DNA specific 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a single-stranded DNA molecule. MF
GO:0045146 initiation of acetate catabolic process by acetate The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. BP
GO:0045147 regulation of initiation of acetate catabolic process by acetate Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. BP
GO:0031789 muscarinic acetylcholine receptor binding Interacting selectively with a muscarinic acetylcholine receptor. MF
GO:0031788 motilin receptor binding Interacting selectively with a motilin receptor. MF
GO:0031781 type 3 melanocortin receptor binding Interacting selectively with a type 3 melanocortin receptor. MF
GO:0031780 adrenocorticotropic hormone receptor binding Interacting selectively with an adrenocorticotropic hormone receptor. MF
GO:0031783 type 5 melanocortin receptor binding Interacting selectively with a type 5 melanocortin receptor. MF
GO:0031782 type 4 melanocortin receptor binding Interacting selectively with a type 4 melanocortin receptor. MF
GO:0031785 type 1A melatonin receptor binding Interacting selectively with a type 1A melatonin receptor. MF
GO:0031784 melatonin receptor binding Interacting selectively with a melatonin receptor. MF
GO:0031787 H9 melatonin receptor binding Interacting selectively with a H9 melatonin receptor. MF
GO:0031786 type 1B melatonin receptor binding Interacting selectively with a type 1B melatonin receptor. MF
GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. BP
GO:0009088 threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. BP
GO:0009085 lysine biosynthetic process The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid. BP
GO:0009084 glutamine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. BP
GO:0009087 methionine catabolic process The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. BP
GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. BP
GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. BP
GO:0009080 pyruvate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine. BP
GO:0009083 branched chain family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. BP
GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. BP
GO:0031433 telethonin binding Interacting selectively with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. MF
GO:0031432 titin binding Interacting selectively with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. MF
GO:0031431 Dbf4-dependent protein kinase complex A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins. CC
GO:0031430 M line The midline of aligned thick filaments in a sarcomere; location of specific proteins that link adjacent thick filaments to each other. CC
GO:0031437 regulation of mRNA cleavage Any process that modulates the frequency, rate or extent of mRNA cleavage, any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. BP
GO:0031436 BRCA1-BARD1 complex A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage. CC
GO:0031435 mitogen-activated protein kinase kinase kinase binding Interacting selectively with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. MF
GO:0031434 mitogen-activated protein kinase kinase binding Interacting selectively with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. MF
GO:0031439 positive regulation of mRNA cleavage Any process that activates or increases the frequency, rate or extent of mRNA cleavage. BP
GO:0031438 negative regulation of mRNA cleavage Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cleavage. BP
GO:0043591 endospore external encapsulating structure The structures that lie outside the inner membrane and surround the entire endospore. CC
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. MF
GO:0043593 endospore coat The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination. CC
GO:0046519 sphingoid metabolic process The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. BP
GO:0016504 protease activator activity Increases the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds. MF
GO:0016505 apoptotic protease activator activity NA MF
GO:0044239 salivary polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth. BP
GO:0044238 primary metabolic process Reactions involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. BP
GO:0016507 fatty acid beta-oxidation multienzyme complex A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. CC
GO:0032209 positive regulation of telomere maintenance via recombination Any process that activates or increases the frequency, rate or extent of recombinational processes involved in the maintenance of proper telomeric length. BP
GO:0032208 negative regulation of telomere maintenance via recombination Any process that stops, prevents or reduces the frequency, rate or extent of recombinational processes involved in the maintenance of proper telomeric length. BP
GO:0032205 negative regulation of telomere maintenance Any process that stops, prevents or reduces the frequency, rate or extent of the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA. BP
GO:0016500 protein-hormone receptor activity Combining with a protein hormone to initiate a change in cell activity. MF
GO:0009623 response to parasitic fungus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection. BP
GO:0032206 positive regulation of telomere maintenance Any process that activates or increases the frequency, rate or extent of the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA. BP
GO:0032201 telomere maintenance via semi-conservative replication The process whereby telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors. BP
GO:0009624 response to nematode A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. BP
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. BP
GO:0009626 hypersensitive response The rapid death of plant cells in response to invasion by a pathogen. BP
GO:0046510 UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP. MF
GO:0016503 pheromone receptor activity Combining with a pheromone to initiate a change in cell activity. MF
GO:0019408 dolichol biosynthetic process The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. BP
GO:0042827 platelet dense granule Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. Contain a highly condensed core consisting of serotonin, calcium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. CC
GO:0000414 regulation of histone H3-K36 methylation Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. BP
GO:0047159 1-alkenylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA. MF
GO:0047158 sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucoside = 1,2-bis-O-sinapoyl beta-D-glucoside + beta-D-glucose. MF
GO:0042309 homoiothermy The processes by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. BP
GO:0042308 negative regulation of protein import into nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. BP
GO:0047151 methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Catalysis of the reaction: FADH + H+ + tRNA U(psi)C = FAD+ + tRNA T(psi)C + THF. MF
GO:0047150 betaine-homocysteine S-methyltransferase activity Catalysis of the reaction: homocysteine + betaine = L-methionine + dimethylglycine. MF
GO:0047153 deoxycytidylate 5-hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate. MF
GO:0042304 regulation of fatty acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. BP
GO:0047155 3-hydroxymethylcephem carbamoyltransferase activity Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem. MF
GO:0042302 structural constituent of cuticle The action of a molecule that contributes to the structural integrity of a cuticle. MF
GO:0047157 myelin-proteolipid O-palmitoyltransferase activity Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA. MF
GO:0047156 acetoin-ribose-5-phosphate transaldolase activity Catalysis of the reaction: ribose-5-phosphate + 3-hydroxybutan-2-one = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde. MF
GO:0006219 deoxyuridine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. BP
GO:0006218 uridine catabolic process The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids. BP
GO:0006214 thymidine catabolic process The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA. BP
GO:0006217 deoxycytidine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. BP
GO:0006216 cytidine catabolic process The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside. BP
GO:0006211 5-methylcytosine catabolic process The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA. BP
GO:0006210 thymine catabolic process The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. BP
GO:0006213 pyrimidine nucleoside metabolic process The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0006212 uracil catabolic process The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. BP
GO:0000327 lytic vacuole within protein storage vacuole A membrane-bound compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole. CC
GO:0000326 protein storage vacuole A compound organelle of plants where there is a lytic vacuole within a storage vacuole. CC
GO:0000325 vacuole (sensu Magnoliophyta) Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0000324 vacuole (sensu Fungi) The vacuole is a large, membrane-bound organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0000323 lytic vacuole A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. CC
GO:0000322 storage vacuole A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules. CC
GO:0000321 re-entry into mitotic cell cycle after pheromone arrest The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. BP
GO:0000320 re-entry into mitotic cell cycle The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. BP
GO:0000329 vacuolar membrane (sensu Fungi) The lipid bilayer separating the vacuole from the cytoplasm of the cell. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0000328 vacuolar lumen (sensu Fungi) The volume enclosed within the vacuolar membrane of the vacuole. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0050883 musculoskeletal movement, spinal reflex action Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord. BP
GO:0050882 voluntary musculoskeletal movement The physiological processes associated with the voluntary movement of an organism or a part of an organism. BP
GO:0050881 musculoskeletal movement The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. BP
GO:0050880 regulation of blood vessel size Any process that modulates the size of blood vessels. BP
GO:0050887 determination of sensory modality The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain. BP
GO:0050886 endocrine process The hormonal, neural, and secretory processes that release products into the blood or lymph. These products have specific effects on other organs. BP
GO:0050885 regulation of balance The processes that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. BP
GO:0050884 regulation of posture The processes by which an organism voluntarily modulates its posture, the alignment of its anatomical parts. BP
GO:0050889 determination of stimulus intensity The determination of the perceived strength of a sensory stimulus. BP
GO:0050888 determination of stimulus location The determination of where on the body surface, within the body or in the environment a stimulus originates. BP
GO:0031848 protection from non-homologous end joining at telomere A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse. BP
GO:0031849 olfactory receptor binding Interacting selectively with an olfactory receptor. MF
GO:0031842 type 1 neuropeptide Y receptor binding Interacting selectively with a type 1 neuropeptide Y receptor. MF
GO:0031843 type 2 neuropeptide Y receptor binding Interacting selectively with a type 2 neuropeptide Y receptor. MF
GO:0031840 type 2 neuromedin U receptor binding Interacting selectively with a type 2 neuromedin U receptor. MF
GO:0031841 neuropeptide Y receptor binding Interacting selectively with a neuropeptide Y receptor. MF
GO:0031846 neurotensin receptor binding Interacting selectively with a neurotensin receptor. MF
GO:0031847 type 1 neurotensin receptor binding Interacting selectively with a type 1 neurotensin receptor. MF
GO:0031844 type 4 neuropeptide Y receptor binding Interacting selectively with a type 4 neuropeptide Y receptor. MF
GO:0031845 type 5 neuropeptide Y receptor binding Interacting selectively with a type 5 neuropeptide Y receptor. MF
GO:0050775 positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. BP
GO:0050774 negative regulation of dendrite morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of dendrite morphogenesis. BP
GO:0050777 negative regulation of immune response Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. BP
GO:0050776 regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. BP
GO:0050771 negative regulation of axonogenesis Any process that stops, prevents or reduces the frequency, rate or extent of axonogenesis. BP
GO:0050770 regulation of axonogenesis Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. BP
GO:0050773 regulation of dendrite development Any process that modulates the frequency, rate or extent of dendrite development. BP
GO:0050772 positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis. BP
GO:0050779 RNA destabilization Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. BP
GO:0050778 positive regulation of immune response Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. BP
GO:0048932 myelination of posterior lateral line nerve axons The formation of compact myelin sheaths around the axons of the posterior lateral line nerve. BP
GO:0048933 afferent axon development in the posterior lateral line nerve The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve. BP
GO:0048930 glial cell migration in the posterior lateral line nerve The movement of glial cells along the axons in the posterior lateral line nerve. BP
GO:0048931 posterior lateral line nerve glial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve. BP
GO:0048936 peripheral nervous system neuron axonogenesis Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells. BP
GO:0005747 respiratory chain complex I (sensu Eukaryota) A part of the respiratory chain, containing about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron; the iron undergoes oxidation-reduction between Fe(II) and Fe(III). Catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0048934 peripheral nervous system neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. BP
GO:0048935 peripheral nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. BP
GO:0048938 lateral line nerve glial cell morphogenesis during differentiation The process by which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initally relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve. BP
GO:0048939 anterior lateral line nerve glial cell development The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0005294 neutral L-amino acid porter activity NA MF
GO:0005295 neutral amino acid:sodium symporter activity Catalysis of the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in). MF
GO:0002244 hemopoietic progenitor cell differentiation The process whereby a unspecialized hemopoietic stem cell acquires the specialized features of a hemopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. BP
GO:0005297 hydrogen:proline symporter activity Catalysis of the reaction: proline(out) + H+(out) = proline(in) + H+(in). MF
GO:0002242 defense response to parasitic plant Reactions triggered in response to the presence of a parasitic plant that act to protect an organism. BP
GO:0002243 detection of parasitic plant The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal. BP
GO:0005292 high-affinity lysine transporter activity NA MF
GO:0002241 response to parasitic plant A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant. BP
GO:0048688 negative regulation of sprouting of injured axon Any process that stops, prevents or reduces the frequency, rate or extent of sprouting of an injured axon. BP
GO:0048689 formation of growth cone in injured axon The formation of a growth cone in an injured axon. BP
GO:0002248 connective tissue replacement during inflammatory response The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared during or following an inflammatory response. BP
GO:0002249 lymphocyte anergy Any process contributing to lymphocyte anergy, a state of functional inactivation. BP
GO:0004165 dodecenoyl-CoA delta-isomerase activity Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA. MF
GO:0004164 diphthine synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. MF
GO:0004167 dopachrome isomerase activity Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. MF
GO:0004166 dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate. MF
GO:0004161 dimethylallyltranstransferase activity Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. MF
GO:0004160 dihydroxy-acid dehydratase activity Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. MF
GO:0007588 excretion The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. BP
GO:0007589 fluid secretion The regulated release of a fluid by a cell or group of cells. BP
GO:0007586 digestion The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. BP
GO:0007587 sugar utilization NA BP
GO:0007584 response to nutrient A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. BP
GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. BP
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. MF
GO:0004168 dolichol kinase activity Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. MF
GO:0007580 extrachromosomal circular DNA accumulation during cell aging Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication. BP
GO:0001539 ciliary or flagellar motility Locomotion due to movement of cilia or flagella. BP
GO:0001535 radial spokehead Protein complex forming part of eukaryotic flagellar apparatus. CC
GO:0001534 radial spoke Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules. CC
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. MF
GO:0001536 radial spoke stalk Globular portion of the radial spoke that projects towards the central pair of microtubules. CC
GO:0001531 interleukin-21 receptor binding Interacting selectively with the interleukin-21 receptor. MF
GO:0001530 lipopolysaccharide binding Interacting selectively with lipopolysaccharide. MF
GO:0001533 cornified envelope An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells. CC
GO:0001532 interleukin-21 receptor activity Combining with interleukin-21 to initiate a change in cell activity. MF
GO:0006985 EOR-mediated activation of NF-kappaB The conversion of inactive NF-kappaB to the active form, thereby allowing it to activate transcription of target genes, as a result of signaling from the endoplasmic reticulum. BP
GO:0006984 ER-nuclear signaling pathway Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. BP
GO:0006987 unfolded protein response, activation of signaling protein activity The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response. BP
GO:0006986 response to unfolded protein A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. BP
GO:0006981 activation of SoxR protein The conversion of the SoxR transcription factor to its active (oxidized) form. BP
GO:0006980 redox signal response NA BP
GO:0006983 ER overload response The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB. BP
GO:0006982 response to lipid hydroperoxide A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids. BP
GO:0042688 crystal cell differentiation The process by which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. BP
GO:0042689 regulation of crystal cell differentiation Any process that modulates the frequency, rate or extent of crystal cell differentiation. BP
GO:0042682 regulation of cone cell fate specification Any process that mediates the specification of a cell into a cone cell. BP
GO:0042683 negative regulation of cone cell fate specification Any process that restricts, stops or prevents a cell from specifying into a cone cell. BP
GO:0042680 cone cell fate determination Process by which a cell becomes capable of differentiating autonomously into a cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0042681 regulation of cone cell fate specification (sensu Endopterygota) Any process that mediates the specification of a cell into a cone cell. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0042686 regulation of cardioblast cell fate specification Any process that mediates the specification of a cell into a cardioblast. BP
GO:0042684 cardioblast cell fate commitment The process by which a cell becomes committed to becoming a cardioblast. BP
GO:0042685 cardioblast cell fate specification Process by which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0015930 glutamate synthase activity Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. MF
GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells. BP
GO:0015932 nucleobase, nucleoside, nucleotide and nucleic acid transporter activity Enables the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells. MF
GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). CC
GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. CC
GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. BP
GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. BP
GO:0015938 coenzyme A catabolic process The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. BP
GO:0015939 pantothenate metabolic process The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. BP
GO:0051611 regulation of serotonin uptake Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell. BP
GO:0051610 serotonin uptake The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. BP
GO:0051613 positive regulation of serotonin uptake Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell. BP
GO:0051612 negative regulation of serotonin uptake Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of serotonin into a cell. BP
GO:0051615 histamine uptake The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. BP
GO:0051614 inhibition of serotonin uptake Any process that prevents the activation of the directed movement of serotonin into a cell. BP
GO:0051617 negative regulation of histamine uptake Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of histamine into a cell. BP
GO:0051616 regulation of histamine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell. BP
GO:0051619 inhibition of histamine uptake Any process that prevents the activation of the directed movement of histamine into a cell. BP
GO:0051618 positive regulation of histamine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell. BP
GO:0009629 response to gravity A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. BP
GO:0009628 response to abiotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. BP
GO:0032204 regulation of telomere maintenance Any process that modulates the frequency, rate or extent of processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA. BP
GO:0015341 zinc efflux permease activity Catalysis of the reaction: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force, possibly by proton antiport. MF
GO:0009625 response to insect A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect. BP
GO:0015346 ferric triacetylfusarinine C:hydrogen symporter activity Catalysis of the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in). MF
GO:0009627 systemic acquired resistance The salicylic acid mediated response to a pathogen which confers broad spectrum resistance. BP
GO:0032202 telomere formation The creation of a telomere at a non-telomeric double-stranded DNA end. BP
GO:0006159 deoxyadenosine phosphorolysis NA BP
GO:0006152 purine nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0006150 hypoxanthine oxidation NA BP
GO:0006151 xanthine oxidation The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. BP
GO:0006156 adenosine phosphorolysis NA BP
GO:0006157 deoxyadenosine catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. BP
GO:0006154 adenosine catabolic process The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. BP
GO:0008110 histidine transaminase activity Catalysis of the reaction: L-histidine + 2-oxoglutarate = imidazol-5-yl-pyruvate + L-glutamate. MF
GO:0008111 alpha-methylacyl-CoA racemase activity Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA. MF
GO:0008112 nicotinamide N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide. MF
GO:0008113 protein-methionine-S-oxide reductase activity Catalysis of the reaction: protein L-methionine + thioredoxin disulfide = protein L-methionine S-oxide + thioredoxin. MF
GO:0008114 phosphogluconate 2-dehydrogenase activity Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH. MF
GO:0008115 sarcosine oxidase activity Catalysis of the reaction: sarcosine + H2O + O2 = glycine + formaldehyde + H2O2. MF
GO:0008116 prostaglandin-I synthase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate. MF
GO:0008117 sphinganine-1-phosphate aldolase activity Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. MF
GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. MF
GO:0008119 thiopurine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. MF
GO:0022024 BMP signaling pathway involved in forebrain neuron fate commitment The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. BP
GO:0022025 leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. BP
GO:0022026 epidermal growth factor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. BP
GO:0022027 interkinetic nuclear migration The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle. BP
GO:0022020 medial ganglionic eminence cell proliferation The multiplication or reproduction of medial ganglionic eminence cells, resulting in the rapid expansion of a cell population. BP
GO:0022021 caudal ganglionic eminence cell proliferation The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the rapid expansion of a cell population. BP
GO:0022022 septal cell proliferation The multiplication or reproduction of septal cells, resulting in the rapid expansion of a cell population. BP
GO:0022023 radial glial cell fate commitment in the forebrain The process whereby the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain. BP
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. BP
GO:0022029 telencephalon cell migration The orderly movement of cells from one site to another at least one of which is located in the telencephalon. BP
GO:0050520 phosphatidylcholine synthase activity Catalysis of the reaction: CDP-diacylglycerol + choline = CMP + phosphatidylcholine. MF
GO:0050521 alpha-glucan, water dikinase activity Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate. MF
GO:0050522 oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP. MF
GO:0050524 coenzyme-B sulfoethylthiotransferase activity Catalysis of the reaction: 2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane. 2-(methylthio)ethanesulfonate is also known as methyl-CoM; N-(7-mercaptoheptanoyl)threonine 3-O-phosphate is also known as coenzyme B. MF
GO:0050525 cutinase activity Catalysis of the reaction: cutin + H2O = cutin monomers. MF
GO:0009010 sorbitol-6-phosphate 2-dehydrogenase activity Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. MF
GO:0050527 poly(3-hydroxyoctanoate) depolymerase activity Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x = 1-5. MF
GO:0047799 cyclopentanone monooxygenase activity Catalysis of the reaction: cyclopentanone + NADPH + O2 = 5-valerolactone + NADP+ + H2O. MF
GO:0047798 cyclomaltodextrinase activity Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin. MF
GO:0047797 cyclohexanone dehydrogenase activity Catalysis of the reaction: cyclohexanone + acceptor = cyclohex-2-enone + reduced acceptor. MF
GO:0047796 cyclohexane-1,3-dione hydrolase activity Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate. MF
GO:0047795 cyclohexane-1,2-diol dehydrogenase activity Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH. MF
GO:0047794 cyclohexadienyl dehydrogenase activity Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2. MF
GO:0047793 cycloeucalenol cycloisomerase activity Catalysis of the reaction: cycloeucalenol = obtusifoliol. MF
GO:0047792 cyanohydrin beta-glucosyltransferase activity Catalysis of the reaction: UDPglucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside. MF
GO:0047791 cucurbitacin delta23-reductase activity Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+. MF
GO:0047790 creatinine deaminase activity Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3. MF
GO:0043489 RNA stabilization Prevention of degradation of RNA molecules. BP
GO:0043488 regulation of mRNA stability Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. BP
GO:0043487 regulation of RNA stability Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. BP
GO:0043486 histone exchange The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. BP
GO:0043485 endosome to pigment granule transport The directed movement of substances from endosomes to pigment granules. BP
GO:0043484 regulation of RNA splicing Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. BP
GO:0043483 anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, occurring during anthocyanin accumulation in a tissue in response to a UV light stimulus. BP
GO:0043482 cellular pigment accumulation The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. BP
GO:0043481 anthocyanin accumulation in tissues in response to UV light The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus. BP
GO:0043480 pigment accumulation in tissues The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus. BP
GO:0016416 O-palmitoyltransferase activity Catalysis of the transfer of an palmitoyl group to an oxygen atom on the acceptor molecule. MF
GO:0016417 S-acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. MF
GO:0016414 O-octanoyltransferase activity Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule. MF
GO:0016415 octanoyltransferase activity Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. MF
GO:0016412 serine O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule. MF
GO:0016413 O-acetyltransferase activity Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. MF
GO:0016410 N-acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. MF
GO:0016411 acylglycerol O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. MF
GO:0016418 S-acetyltransferase activity Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule. MF
GO:0016419 S-malonyltransferase activity Catalysis of the transfer of an malonyl group to a sulfur atom on the acceptor molecule. MF
GO:0046619 optic placode formation (sensu Mammalia) Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0046618 drug export The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle. BP
GO:0030089 phycobilisome Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II. CC
GO:0030085 PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides. CC
GO:0030084 PSI associated light-harvesting complex I, LHCIb subcomplex A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm. CC
GO:0030081 B800-820 antenna complex Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. CC
GO:0030080 B875 antenna complex Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm. CC
GO:0030083 PSI associated light-harvesting complex I, LHCIa subcomplex A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm. CC
GO:0030082 B800-850 antenna complex Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. CC
GO:0030629 U6 snRNA 3'-end binding Interacting selectively with the 3' end of the U6 small nuclear RNA (U6 snRNA). MF
GO:0030628 pre-mRNA 3'-splice site binding Interacting selectively with the pre-mRNA 3' splice site sequence. MF
GO:0030621 U4 snRNA binding Interacting selectively with the U4 small nuclear RNA (U4 snRNA). MF
GO:0030620 U2 snRNA binding Interacting selectively with the U2 small nuclear RNA (U2 snRNA). MF
GO:0030623 U5 snRNA binding Interacting selectively with the U5 small nuclear RNA (U5 snRNA). MF
GO:0030622 U4atac snRNA binding Interacting selectively with the U4atac small nuclear RNA (U4atac snRNA). MF
GO:0030625 U11 snRNA binding Interacting selectively with the U11 small nuclear RNA (U11 snRNA). MF
GO:0030624 U6atac snRNA binding Interacting selectively with the U6atac small nuclear RNA (U6atac snRNA). MF
GO:0030627 pre-mRNA 5'-splice site binding Interacting selectively with the pre-mRNA 5' splice site sequence. MF
GO:0030626 U12 snRNA binding Interacting selectively with the U12 small nuclear RNA (U12 snRNA). MF
GO:0042233 interleukin-15 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-15. BP
GO:0042232 interleukin-14 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-14. BP
GO:0018849 muconate cycloisomerase activity Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate. MF
GO:0018848 pinocarveol isomerase activity Catalysis of the reaction: pinocarveol = carveol. MF
GO:0018842 3-carboxymuconate cycloisomerase type II activity Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone. MF
GO:0018840 chlorodienelactone isomerase activity Catalysis of the reaction: trans-2-chlorodienelactone = cis-2-chlorodienelactone. MF
GO:0018847 alpha-pinene lyase activity Catalysis of the reaction: alpha-pinene = limonene. MF
GO:0018846 styrene-oxide isomerase activity Catalysis of the reaction: styrene oxide = phenylacetaldehyde. MF
GO:0018845 2-hydroxychromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = trans-o-hydroxybenzylidenepyruvate. MF
GO:0018844 2-hydroxytetrahydrofuran isomerase activity Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde. MF
GO:0016699 oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein. MF
GO:0030206 chondroitin sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. BP
GO:0030204 chondroitin sulfate metabolic process The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate. BP
GO:0030200 heparan sulfate proteoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. BP
GO:0048060 negative gravitaxis The directed movement of a motile cell or organism away from the source of gravity. BP
GO:0048061 positive gravitaxis The directed movement of a motile cell or organism towards the source of gravity. BP
GO:0030208 dermatan sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. BP
GO:0002466 peripheral tolerance induction to self antigen Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. BP
GO:0002467 germinal center formation The process by which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. BP
GO:0002464 peripheral tolerance induction to nonself antigen Tolerance induction to nonself antigens in the periphery. BP
GO:0002465 peripheral tolerance induction Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. BP
GO:0002462 tolerance induction to nonself antigen Tolerance induction in response to nonself antigens. BP
GO:0002463 central tolerance induction to nonself antigen Tolerance induction to nonself antigens in the central lymphoid organs. BP
GO:0002460 adaptive immune response (sensu Gnathostomata) An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory), as in, but not restricted to, the jawed vertebrates (Gnathostomata, ncbi_taxonomy_id:7776). BP
GO:0002461 tolerance induction dependent upon immune response Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation. BP
GO:0002468 dendritic cell antigen processing and presentation The process by which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0002469 myeloid dendritic cell antigen processing and presentation The process by which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. BP
GO:0048065 male courtship behavior (sensu Insecta), wing extension The process during courtship where the male extends his wings. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0052039 modification by symbiont of host cytoskeleton The process by which an organism effects a change in the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0006398 histone mRNA 3'-end processing Any process involved in forming the mature 3' end of a histone mRNA molecule. BP
GO:0006399 tRNA metabolic process The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. BP
GO:0006390 transcription from mitochondrial promoter The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. BP
GO:0006391 transcription initiation from mitochondrial promoter NA BP
GO:0006392 RNA elongation from mitochondrial promoter The extension of an RNA molecule after transcription initiation at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase. BP
GO:0006393 RNA transcription termination from mitochondrial promoter The process by which transcription from a mitochondrial promoter is terminated. BP
GO:0006396 RNA processing Any process involved in the conversion of a primary RNA transcript into one or more mature RNA molecules. BP
GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. BP
GO:0052037 negative regulation by symbiont of host defense response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042538 hyperosmotic salinity response A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. BP
GO:0042539 hypotonic salinity response A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. BP
GO:0042534 regulation of tumor necrosis factor-alpha biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. BP
GO:0042535 positive regulation of tumor necrosis factor-alpha biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. BP
GO:0042536 negative regulation of tumor necrosis factor-alpha biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. BP
GO:0042537 benzene and derivative metabolic process The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. BP
GO:0042530 negative regulation of tyrosine phosphorylation of Stat7 protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a Stat7 protein. BP
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. BP
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. BP
GO:0042533 tumor necrosis factor-alpha biosynthetic process The chemical reactions and pathways resulting in the formation of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. BP
GO:0048763 calcium-induced calcium release activity Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration. MF
GO:0048762 mesenchymal cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal cell. BP
GO:0005151 interleukin-1, Type II receptor binding Interacting selectively with a Type II interleukin-1 receptor. MF
GO:0005150 interleukin-1, Type I receptor binding Interacting selectively with a Type I interleukin-1 receptor. MF
GO:0048767 root hair elongation The process by which the root hair grows longer. BP
GO:0048766 root hair initiation The process by which a protrusion or bulge is formed at the site of plant root hair outgrowth. BP
GO:0005155 epidermal growth factor receptor activating ligand activity NA MF
GO:0005154 epidermal growth factor receptor binding Interacting selectively with the epidermal growth factor receptor. MF
GO:0048769 sarcomerogenesis The process by which sarcomeres are added in series within a fiber. BP
GO:0005158 insulin receptor binding Interacting selectively with the insulin receptor. MF
GO:0004824 lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). MF
GO:0004825 methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). MF
GO:0004826 phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). MF
GO:0004827 proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). MF
GO:0004820 glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). MF
GO:0004821 histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). MF
GO:0004822 isoleucine-tRNA ligase activity Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). MF
GO:0004823 leucine-tRNA ligase activity Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). MF
GO:0004828 serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). MF
GO:0004829 threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). MF
GO:0051031 tRNA transport The directed movement of tRNA, transfer ribonucleic acid, into, out of, within or between cells. BP
GO:0051030 snRNA transport The directed movement of snRNA, small nuclear ribonucleic acid, into, out of, within or between cells. BP
GO:0051033 RNA transporter activity Enables the directed movement of RNA, ribonucleic acid, into, out of, within or between cells. MF
GO:0051032 nucleic acid transporter activity Enables the directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of, within or between cells. MF
GO:0051035 DNA transporter activity Enables the directed movement of DNA, deoxyribonucleic acid, into, out of, within or between cells. MF
GO:0051034 tRNA transporter activity Enables the directed movement of tRNA, transfer ribonucleic acid, into, out of, within or between cells. MF
GO:0051037 regulation of transcription, meiotic Any process that modulates the frequency, rate or extent of transcription during meiosis. BP
GO:0051036 regulation of endosome volume Any process that modulates the volume of an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. BP
GO:0051039 positive regulation of transcription, meiotic Any process that activates or increases the frequency, rate or extent of transcription during meiosis. BP
GO:0051038 negative regulation of transcription, meiotic Any process that stops, prevents or reduces the frequency, rate or extent of transcription during meiosis. BP
GO:0010151 chloroplast elongation Expansion of the chloroplast that usually precedes division. BP
GO:0007424 tracheal system development (sensu Insecta) The process whose specific outcome is the progression of the tracheal system over time, from its formation to the mature structure. The traceal system is the respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007427 tracheal epithelial cell migration (sensu Insecta) The orderly movement of tracheal cells during development of the tracheal system. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007426 tracheal outgrowth (sensu Insecta) The projection of tracheal branches of the respiratory system towards their target tissues. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0010155 regulation of proton transport Any process that modulates the frequency, rate or extent of proton transport into, out of, within or between cells. BP
GO:0010154 fruit development The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant. BP
GO:0010157 response to chlorate A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus. BP
GO:0007422 peripheral nervous system development The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. BP
GO:0010159 specification of organ position The regionalization process by which information that determines the correct position at which organ primordia are formed is generated and perceived resulting in correct positioning of the new organ. BP
GO:0010158 abaxial cell fate specification Process by which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0007429 secondary tracheal branching (sensu Insecta) Sprouting of secondary branches in the tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007428 primary tracheal branching (sensu Insecta) Formation of primary branches in the tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0015309 cycloheximide:hydrogen antiporter activity Catalysis of the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out). MF
GO:0015308 amiloride:hydrogen antiporter activity Catalysis of the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out). MF
GO:0018304 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide. BP
GO:0018305 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide. BP
GO:0018306 iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide. BP
GO:0018307 enzyme active site formation The modification of part of an enzyme to form the active site. BP
GO:0018301 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon. BP
GO:0018302 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide. BP
GO:0018303 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide. BP
GO:0018309 protein-FMN linkage NA BP
GO:0042307 positive regulation of protein import into nucleus Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. BP
GO:0042306 regulation of protein import into nucleus Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. BP
GO:0042305 specification of segmental identity, mandibular segment The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0001702 gastrulation (sensu Deuterostomia) Gastrulation, as in, but not restricted to, the taxon Deuterostomia (Deuterostomia, ncbi_taxonomy_id:33511). BP
GO:0001703 gastrulation (sensu Protostomia) Gastrulation, as in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0001700 embryonic development (sensu Insecta) The process whose specific outcome is the progression of the embryo over time, from zygote formation to the hatching of the first instar larva. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0047152 methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide. MF
GO:0001706 endoderm formation The formation of the endoderm during gastrulation. BP
GO:0001707 mesoderm formation The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. BP
GO:0001704 formation of primary germ layer The formation of the ectoderm, mesoderm and endoderm during gastrulation. BP
GO:0001705 ectoderm formation The formation of ectoderm during gastrulation. BP
GO:0042303 molting cycle The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. BP
GO:0001708 cell fate specification The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. BP
GO:0001709 cell fate determination Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. BP
GO:0047154 methylmalonyl-CoA carboxytransferase activity Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA. MF
GO:0042301 phosphate binding Interacting selectively with phosphate. MF
GO:0042300 beta-amyrin synthase activity Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into beta-amyrin. MF
GO:0021960 anterior commissure morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal processes is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum. BP
GO:0021961 posterior commissure morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon. BP
GO:0016656 monodehydroascorbate reductase (NADH) activity Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate. MF
GO:0016657 oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group. MF
GO:0021964 rubrospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord. BP
GO:0016651 oxidoreductase activity, acting on NADH or NADPH Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0021966 corticospinal neuron axon guidance The process by which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues. BP
GO:0016653 oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. MF
GO:0021968 corticospinal neuron axon guidance through the internal capsule The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues. BP
GO:0021969 corticospinal neuron axon guidance through the cerebral peduncle The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues. BP
GO:0052078 negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052079 positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052070 negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052071 positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052072 positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052073 positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052074 positive regulation by symbiont of host salicylic acid-mediated defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052075 positive regulation by symbiont of host jasmonic acid-mediated defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052076 positive regulation by symbiont of host ethylene-mediated defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052077 modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway Any process by which an organism modulates the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0006936 muscle contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. BP
GO:0048078 positive regulation of eye pigmentation (sensu Endopterygota) Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0008954 peptidoglycan synthetase activity NA MF
GO:0006939 smooth muscle contraction A process leading to shortening and/or development of tension in smooth muscle tissue. BP
GO:0019167 3-octaprenyl-4-hydroxybenzoate decarboxylase activity NA MF
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+. MF
GO:0019165 thiamin kinase activity Catalysis of the reaction: ATP + thiamin = ADP + thiamin phosphate. MF
GO:0019164 pyruvate synthase activity Catalysis of the reaction: pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin. MF
GO:0019163 pyridoxamine-phosphate transaminase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate. MF
GO:0008956 peptidyl-dipeptidase Dcp activity Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly. MF
GO:0019161 diamine transaminase activity Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate. MF
GO:0019160 NMN nucleosidase activity Catalysis of the reaction: nicotinamide D-ribonucleotide + H2O = nicotinamide + D-ribose 5-phosphate. MF
GO:0008957 phenylacetaldehyde dehydrogenase activity Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+. MF
GO:0008951 palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity NA MF
GO:0008953 penicillin amidase activity Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate. MF
GO:0031110 regulation of microtubule polymerization or depolymerization Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. BP
GO:0031111 negative regulation of microtubule polymerization or depolymerization Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. BP
GO:0031112 positive regulation of microtubule polymerization or depolymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. BP
GO:0031113 regulation of microtubule polymerization Any process that modulates the frequency, rate or extent of microtubule polymerization. BP
GO:0031114 regulation of microtubule depolymerization Any process that modulates the frequency, rate or extent of microtubule depolymerization. BP
GO:0031115 negative regulation of microtubule polymerization Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization. BP
GO:0031116 positive regulation of microtubule polymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization. BP
GO:0031117 positive regulation of microtubule depolymerization Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. BP
GO:0031118 rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. BP
GO:0031119 tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. BP
GO:0051798 positive regulation of hair follicle development Any process that activates or increases the frequency, rate or extent of hair follicle development. BP
GO:0051799 negative regulation of hair follicle development Any process that stops, prevents or reduces the frequency, rate or extent of hair follicle development. BP
GO:0051794 regulation of catagen Any process that modulates the frequency, rate or extent of catagen, the regression phase of the hair cycle. BP
GO:0051795 positive regulation of catagen Any process that activates or increases the frequency, rate or extent of catagen, the regression phase of the hair cycle. BP
GO:0051796 negative regulation of catagen Any process that stops, prevents or reduces the frequency, rate or extent of catagen, the regression phase of the hair cycle. BP
GO:0051797 regulation of hair follicle development Any process that modulates the frequency, rate or extent of hair follicle development. BP
GO:0051790 short-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than 8 carbons. BP
GO:0051791 medium-chain fatty acid metabolic process The chemical reactions and pathways involving medium-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C8-12. BP
GO:0051792 medium-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of between 8 and 12 carbons. BP
GO:0051793 medium-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of between 8 and 12 carbons. BP
GO:0051866 general adaptation syndrome General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses. BP
GO:0051867 general adaptation syndrome, behavioral process The behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus. BP
GO:0051864 histone demethylase activity (H3-K36 specific) Catalysis of the reaction: methyl-lysine + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. The methyl-lysine residue is at position 36 of histone 3. MF
GO:0031157 regulation of aggregate size Any process that modulates the size of the aggregate formed during fruiting body formation in cellular slime molds. BP
GO:0051862 translocation of molecules into symbiont The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051863 translocation of DNA into symbiont The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051860 evasion or tolerance of symbiont defenses The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051861 glycolipid binding Interacting selectively with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. MF
GO:0008701 4-hydroxy-2-oxovalerate aldolase activity NA MF
GO:0008700 4-hydroxy-2-oxoglutarate aldolase activity Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. MF
GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+. MF
GO:0008705 methionine synthase activity Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine. MF
GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. MF
GO:0008707 4-phytase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate. MF
GO:0008706 6-phospho-beta-glucosidase activity Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose. MF
GO:0008709 7-alpha-hydroxysteroid dehydrogenase activity Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD+ = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH + H+. MF
GO:0008708 glucose dehydrogenase activity Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor. MF
GO:0045458 recombination within rDNA repeats Genetic recombination within the DNA of the genes coding for ribosomal RNA. BP
GO:0045459 iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide. BP
GO:0045456 ecdysteroid biosynthetic process The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. BP
GO:0045457 ecdysteroid secretion The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. BP
GO:0045454 cell redox homeostasis The processes that maintain the redox environment of a cell or compartment within a cell. BP
GO:0045455 ecdysteroid metabolic process The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. BP
GO:0045453 bone resorption The physiologic processes by which bone tissue is lost. BP
GO:0045450 bicoid mRNA localization The processes by which bicoid mRNA is transported to, or maintained in, a specific location. BP
GO:0045451 pole plasm oskar mRNA localization The processes by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. BP
GO:0032123 deep fiber Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm. CC
GO:0047341 fucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: L-fucose 1-phosphate + GTP = guanosine diphosphate fucose + diphosphate. MF
GO:0047342 galactose-1-phosphate thymidylyltransferase activity Catalysis of the reaction: alpha-D-galactose-1-phosphate + dTTP = dTDP-D-galactose + diphosphate. MF
GO:0047343 glucose-1-phosphate cytidylyltransferase activity Catalysis of the reaction: glucose-1-phosphate + CTP = CDP-D-glucose + diphosphate. MF
GO:0047344 glucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: glucose-1-phosphate + GTP = GDP-D-glucose + diphosphate. MF
GO:0047345 ribose-5-phosphate adenylyltransferase activity Catalysis of the reaction: ribose-5-phosphate + ADP = phosphate + adenosine diphosphate ribose. MF
GO:0047346 aldose-1-phosphate adenylyltransferase activity Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose. MF
GO:0047347 aldose-1-phosphate nucleotidyltransferase activity Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose. MF
GO:0047348 glycerol-3-phosphate cytidylyltransferase activity Catalysis of the reaction: glycerol-3-phosphate + CTP = CDPglycerol + diphosphate. MF
GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate. MF
GO:0046431 (R)-4-hydroxymandelate metabolic process The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate). BP
GO:0046430 non-phosphorylated glucose metabolic process The chemical reactions and pathways involving non-phosphorylated forms of glucose. BP
GO:0046433 2-aminoethylphosphonate metabolic process The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms. BP
GO:0046432 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A. BP
GO:0046435 3-(3-hydroxy)phenylpropionate metabolic process The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. BP
GO:0046434 organophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. BP
GO:0046437 D-amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of D-amino acids, the dextrorotatory isomer of amino acids. BP
GO:0046436 D-alanine metabolic process The chemical reactions and pathways involving D-alanine, the dextrorotatory isomer of the amino acid alanine. BP
GO:0046439 L-cysteine metabolic process The chemical reactions and pathways involving L-cysteine, the levorotatory isomer of 2-amino-3-mercaptopropanoic acid. BP
GO:0046438 D-cysteine metabolic process The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin. BP
GO:0002707 negative regulation of lymphocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. BP
GO:0002706 regulation of lymphocyte mediated immunity Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. BP
GO:0002705 positive regulation of leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. BP
GO:0002704 negative regulation of leukocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. BP
GO:0002703 regulation of leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. BP
GO:0002702 positive regulation of production of molecular mediator of immune response Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. BP
GO:0002701 negative regulation of production of molecular mediator of immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. BP
GO:0002700 regulation of production of molecular mediator of immune response Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. BP
GO:0002709 regulation of T cell mediated immunity Any process that modulates the frequency, rate, or extent of T cell mediated immunity. BP
GO:0002708 positive regulation of lymphocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. BP
GO:0050593 N-methylcoclaurine 3'-monooxygenase activity Catalysis of the reaction: (S)-N-methylcoclaurine + NADPH + H+ + O2 = (S)-3'-hydroxy-N-methylcoclaurine + NADP+ + H2O. MF
GO:0035178 turning behavior Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source. BP
GO:0035179 larval turning behavior Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source. BP
GO:0035176 social behavior Behavior that occurs predominantly, or only, in individuals that are part of a group. BP
GO:0035177 larval foraging behavior The movement of a larva through a feeding substrate whilst feeding on food. BP
GO:0035174 histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. MF
GO:0035175 histone serine kinase activity (H3-S10 specific) Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3. MF
GO:0035172 hemocyte proliferation (sensu Arthropoda) The multiplication or reproduction of hemocytes, resulting in the rapid expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body). As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0035173 histone kinase activity Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. MF
GO:0035170 lymph gland crystal cell differentiation The process whereby a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. BP
GO:0035171 lamellocyte differentiation The process by which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. BP
GO:0050599 deacetoxycephalosporin-C synthase activity Catalysis of the reaction: penicillin-N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O. MF
GO:0050598 taxane 13-alpha-hydroxylase activity Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5-alpha,13-alpha-diol. MF
GO:0048561 establishment of organ orientation The process that determines the orientation of an organ or tissue with reference to an axis. BP
GO:0048560 establishment of anatomical structure orientation The process that determines the orientation of an anatomical structure with reference to an axis. BP
GO:0048563 post-embryonic organ morphogenesis Morphogenesis, during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. BP
GO:0048562 embryonic organ morphogenesis Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. BP
GO:0048565 gut development The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. BP
GO:0048564 photosystem I assembly Formation of the photosystem I complex on the thylakoid membrane. BP
GO:0048567 ectodermal gut morphogenesis The process by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form. The ectodermal gut includes those portions of the gut that are derived from ectoderm. BP
GO:0048566 embryonic gut development The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. BP
GO:0048569 post-embryonic organ development Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. BP
GO:0048568 embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. BP
GO:0005742 mitochondrial outer membrane translocase complex A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. CC
GO:0009868 jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance. BP
GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. CC
GO:0009863 salicylic acid mediated signaling pathway A series of molecular signals mediated by salicylic acid. BP
GO:0009862 systemic acquired resistance, salicylic acid mediated signaling pathway The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance. BP
GO:0009861 jasmonic acid and ethylene-dependent systemic resistance The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. BP
GO:0009860 pollen tube growth Growth of pollen via tip extension of the intine wall. BP
GO:0009867 jasmonic acid mediated signaling pathway A series of molecular signals mediated by jasmonic acid. BP
GO:0009866 induced systemic resistance, ethylene mediated signaling pathway The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance. BP
GO:0009865 pollen tube adhesion The process by which the pollen tube adheres to cells of the stigma and style. BP
GO:0009864 induced systemic resistance, jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance. BP
GO:0043146 spindle stabilization The processes involved in maintaining the structure and integrity of the spindle. BP
GO:0043147 meiotic spindle stabilization The cell cycle process whereby spindle integrity is maintained during M phase of meiosis. BP
GO:0043144 snoRNA processing Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA. BP
GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. CC
GO:0043142 single-stranded DNA-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single-stranded DNA; drives another reaction. MF
GO:0043143 translational machinery localization The processes by which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. BP
GO:0043140 ATP-dependent 3' to 5' DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. MF
GO:0043141 ATP-dependent 5' to 3' DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'. MF
GO:0005746 mitochondrial electron transport chain The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane. CC
GO:0043148 mitotic spindle stabilization The cell cycle process whereby spindle integrity is maintained during M phase of mitosis. BP
GO:0043149 stress fiber formation Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts. BP
GO:0005744 mitochondrial inner membrane presequence translocase complex The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. CC
GO:0005745 m-AAA complex Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria. CC
GO:0042439 ethanolamine and derivative metabolic process NA BP
GO:0042438 melanin biosynthetic process The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. BP
GO:0042435 indole derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from indole (2,3-benzopyrrole). BP
GO:0042434 indole derivative metabolic process The chemical reactions and pathways involving compounds derived from indole (2,3-benzopyrrole). BP
GO:0042437 indoleacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants. BP
GO:0042436 indole derivative catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from indole (2,3-benzopyrrole). BP
GO:0042431 indole metabolic process The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). BP
GO:0042430 indole and derivative metabolic process The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan) formed in degradation of tryptophan, and compounds derived from it. BP
GO:0042433 indole catabolic process The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). BP
GO:0042432 indole biosynthetic process The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). BP
GO:0005749 respiratory chain complex II (sensu Eukaryota) A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0009074 aromatic amino acid family catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). BP
GO:0009075 histidine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the histidine family. BP
GO:0009139 pyrimidine nucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009138 pyrimidine nucleoside diphosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0050229 pterocarpin synthase activity Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH. MF
GO:0050228 pterin deaminase activity Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3. MF
GO:0050223 protocatechuate decarboxylase activity Catalysis of the reaction: 3,4-dihydroxybenzoate = catechol + CO2. MF
GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009133 nucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009132 nucleoside diphosphate metabolic process The chemical reactions and pathways involving a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0050227 pteridine oxidase activity Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown. MF
GO:0050226 psychosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate. MF
GO:0050225 pseudouridine kinase activity Catalysis of the reaction: ATP + pseudouridine = ADP + pseudouridine 5'-phosphate. MF
GO:0050224 prunasin beta-glucosidase activity Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile. MF
GO:0003890 beta DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). MF
GO:0003891 delta DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). A DNA polymerase function with both polymerase and 3'-exonuclease activities; functions in DNA replication, mismatch repair and excision repair. MF
GO:0003893 epsilon DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. MF
GO:0003894 zeta DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). A DNA-directed DNA polymerase that functions during replication, to promote the extension of forks whose progression is stopped for any reason; a non-processive enzyme with no 3'-5' exonuclease activity; possesses deoxycytidyl transferase activity, incorporating deoxycytidyl opposite abasic sites. Functions during DNA repair and mutagenesis. Composed of two subunits. MF
GO:0003895 gamma DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). The DNA-directed DNA polymerase responsible for the replication of mitochondrial DNA. MF
GO:0003896 DNA primase activity Catalysis of the synthesis of short RNA primers for the Okazaki fragments on both DNA template strands at the replication fork. A DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. MF
GO:0003899 DNA-directed RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. MF
GO:0009077 histidine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family. BP
GO:0019369 arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. BP
GO:0019368 fatty acid elongation, unsaturated fatty acid Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced. BP
GO:0019365 pyridine nucleotide salvage Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis. BP
GO:0019364 pyridine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. BP
GO:0019367 fatty acid elongation, saturated fatty acid Elongation of a saturated fatty acid chain. BP
GO:0019361 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A. BP
GO:0019360 nicotinamide nucleotide biosynthetic process from niacinamide The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide. BP
GO:0019363 pyridine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. BP
GO:0019362 pyridine nucleotide metabolic process The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. BP
GO:0032623 interleukin-2 production The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032622 interleukin-19 production The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032621 interleukin-18 production The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032620 interleukin-17 production The appearance of interleukin-17 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032627 interleukin-23 production The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032626 interleukin-22 production The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032625 interleukin-21 production The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032624 interleukin-20 production The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032629 interleukin-25 production The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032628 interleukin-24 production The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0048684 positive regulation of collateral sprouting of intact axon in response to injury Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon. BP
GO:0030293 transmembrane receptor protein tyrosine kinase inhibitor activity NA MF
GO:0048685 negative regulation of collateral sprouting of intact axon in response to injury Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon. BP
GO:0005296 L-proline permease activity NA MF
GO:0048687 positive regulation of sprouting of injured axon Any process that activates, maintains or increases the rate of sprouting of an injured axon. BP
GO:0005290 L-histidine transporter activity Enables the directed movement of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of, within or between cells. MF
GO:0005291 high affinity histidine permease activity NA MF
GO:0035185 preblastoderm mitotic cell cycle The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. BP
GO:0048682 sprouting of injured axon The process involved in sprouting of an injured axon. BP
GO:0005293 lysine permease activity Catalysis of the stereospecific transfer of lysine, 2,6-diaminohexanoic acid, across a biological membrane. MF
GO:0019988 charged-tRNA modification The modification of the aminoacyl group of a charged tRNA. BP
GO:0019981 interleukin-6 binding Interacting selectively with interleukin-6. MF
GO:0019980 interleukin-5 binding Interacting selectively with interleukin-5. MF
GO:0019983 interleukin-9 binding Interacting selectively with interleukin-9. MF
GO:0019982 interleukin-7 binding Interacting selectively with interleukin-7. MF
GO:0019985 bypass DNA synthesis The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized replication complex inserts a random nucleotide across from the lesion and then continues DNA synthesis beyond the lesion. This process is often mutagenic. BP
GO:0019984 sigma DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). The function required for sister-chromatid adhesion. MF
GO:0019987 negative regulation of anti-apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of anti-apoptosis. BP
GO:0005299 L-tryptophan permease activity NA MF
GO:0004163 diphosphomevalonate decarboxylase activity Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2. MF
GO:0004162 dimethylnitrosamine demethylase activity Catalysis of the removal of a methyl group from N-nitrosodimethylamine. MF
GO:0006589 octopamine biosynthetic process The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species. BP
GO:0006588 tryptophan hydroxylase activation The process by which the tryptophan hydroxylase enzyme is changed so that is can carry out its enzymatic activity. BP
GO:0006581 acetylcholine catabolic process The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. BP
GO:0006580 ethanolamine metabolic process The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). BP
GO:0006583 melanin biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine. BP
GO:0006582 melanin metabolic process The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. BP
GO:0006585 dopamine biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine. BP
GO:0006584 catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. BP
GO:0006587 serotonin biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. BP
GO:0006586 indolalkylamine metabolic process The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. BP
GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. BP
GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. BP
GO:0006637 acyl-CoA metabolic process The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. BP
GO:0006636 fatty acid desaturation The process by which a fatty acid becomes unsaturated (containing double bonds), for example by removal of two hydrogen atoms, or a hydrogen atom and a hydroxyl group, from adjacent carbon atoms. BP
GO:0006635 fatty acid beta-oxidation The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A. BP
GO:0006634 hexadecanal biosynthetic process The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde. BP
GO:0006639 acylglycerol metabolic process The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. BP
GO:0006638 neutral lipid metabolic process The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. BP
GO:0005584 collagen type I A collagen heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; type I collagen triple helices associate to form banded fibrils. CC
GO:0005585 collagen type II A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. CC
GO:0005586 collagen type III A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils. CC
GO:0005587 collagen type IV A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes. CC
GO:0005581 collagen Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures. CC
GO:0005582 collagen type XV A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes. CC
GO:0005583 fibrillar collagen Any collagen polymer in which collagen triple helices associate to form fibrils. CC
GO:0005588 collagen type V A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils. CC
GO:0005589 collagen type VI A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils. CC
GO:0000293 ferric-chelate reductase activity Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+. MF
GO:0000292 RNA fragment catabolic process The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing. BP
GO:0000291 mRNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. BP
GO:0000290 deadenylation-dependent decapping Cleavage of the 5'-cap of an mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. BP
GO:0000297 spermine transporter activity Enables the directed movement of spermine into, out of, within or between cells. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. MF
GO:0000296 spermine transport The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of, within or between cells. BP
GO:0000295 adenine nucleotide transporter activity Transports adenine nucleotides (AMP, ADP, and ATP) across membranes. MF
GO:0000294 mRNA catabolic process, endonucleolytic cleavage-dependent decay A minor mRNA degradation pathway that begins with an endonucleolytic cleavage to generate unprotected ends. BP
GO:0000299 integral to membrane of membrane fraction Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes. CC
GO:0000298 endopolyphosphatase activity Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. MF
GO:0004983 neuropeptide Y receptor activity Combining with neuropeptide Y to initiate a change in cell activity. MF
GO:0004982 N-formyl peptide receptor activity Combining with an N-formyl peptide to initiate a change in cell activity. MF
GO:0004981 muscarinic acetylcholine receptor activity NA MF
GO:0004980 melanocyte stimulating hormone receptor activity Combining with melanocyte stimulating hormone to initiate a change in cell activity. MF
GO:0004987 kappa-opioid receptor activity NA MF
GO:0004986 delta-opioid receptor activity NA MF
GO:0004985 opioid receptor activity Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity. MF
GO:0004984 olfactory receptor activity Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell. MF
GO:0004989 octopamine receptor activity Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist. MF
GO:0004988 mu-opioid receptor activity NA MF
GO:0043186 P granule A small protein and RNA containing electron dense organelle, not surrounded by a membrane, that is associated with germ nuclei in the gonad and localized to germ cells and their precursors throughout development. CC
GO:0000745 nuclear migration during conjugation without cellular fusion The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion. BP
GO:0000744 karyogamy during conjugation without cellular fusion During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei. BP
GO:0000747 conjugation with cellular fusion The processes that result in the union of cellular and genetic information from compatible mating types. BP
GO:0000746 conjugation The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms. BP
GO:0000741 karyogamy The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. BP
GO:0000740 nuclear membrane fusion The joining of 2 or more lipid bilayer membranes that surround the nucleus. BP
GO:0000743 nuclear migration during conjugation with cellular fusion The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion. BP
GO:0000742 karyogamy during conjugation with cellular fusion During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy. BP
GO:0043187 cell septum surface The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe. CC
GO:0000749 response to pheromone during conjugation with cellular fusion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation with cellular fusion. BP
GO:0000748 conjugation with mutual genetic exchange The processes that result in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange. BP
GO:0004675 transmembrane receptor protein serine/threonine kinase activity NA MF
GO:0004674 protein serine/threonine kinase activity Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. MF
GO:0004677 DNA-dependent protein kinase activity NA MF
GO:0004676 3-phosphoinositide-dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide. MF
GO:0004671 protein-S-isoprenylcysteine O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. MF
GO:0004673 protein histidine kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. MF
GO:0004672 protein kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a protein substrate. MF
GO:0004679 AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of AMP. MF
GO:0018115 peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine The co- or posttranslational modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine. BP
GO:0018114 threonine racemase activity Catalysis of the reaction: L-threonine = D-threonine. MF
GO:0018117 protein amino acid adenylylation The addition of phospho-adenosine to a protein amino acid. BP
GO:0018116 peptidyl-lysine adenylylation The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine. BP
GO:0018111 methionine racemase activity Catalysis of the reaction: L-methionine = D-methionine. MF
GO:0018110 histone arginine kinase activity NA MF
GO:0018113 lysine racemase activity Catalysis of the reaction: L-lysine = D-lysine. MF
GO:0018112 proline racemase activity Catalysis of the reaction: L-proline = D-proline. MF
GO:0018119 peptidyl-cysteine S-nitrosylation The posttranslational S-nitrosylation of peptidyl-cysteine to form peptidyl-S-nitrosyl-L-cysteine. BP
GO:0018118 peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide. BP
GO:0051206 silicate metabolic process The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. BP
GO:0051207 silicic acid transport The directed movement of silicic acid into, out of, within or between cells. Silicic acid, Si(OH)4, is a hydrated form of silicon dioxide that occurs in nature; it is insoluble in water or acids except hydrofluoric acid. BP
GO:0051204 protein insertion into mitochondrial membrane The process by which a protein is incorporated into a mitochondrial membrane. BP
GO:0007219 Notch signaling pathway The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell. BP
GO:0051202 phytochromobilin metabolic process The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity. BP
GO:0051203 peptidyl-aspartic acid reduction to form L-aspartyl aldehyde The posttranslational reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein. BP
GO:0051200 positive regulation of prosthetic group metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group. BP
GO:0051201 negative regulation of prosthetic group metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group. BP
GO:0007212 dopamine receptor signaling pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. BP
GO:0007213 acetylcholine receptor signaling, muscarinic pathway The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine. BP
GO:0007210 serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. BP
GO:0007211 octopamine/tyramine signaling pathway The series of molecular signals generated as a consequence of an octopamine/tyramine receptor binding to one of its physiological ligands. BP
GO:0007216 metabotropic glutamate receptor signaling pathway The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins. BP
GO:0007217 tachykinin signaling pathway The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor. BP
GO:0051208 sequestering of calcium ion The process of binding or confining calcium ions such that they are separated from other components of a biological system. BP
GO:0007215 glutamate signaling pathway The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor. BP
GO:0015535 fucose:hydrogen symporter activity Catalysis of the reaction: fucose(out) + H+(out) = fucose(in) + H+(in). MF
GO:0015536 nucleoside permease activity Catalysis of the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in). MF
GO:0015537 xanthosine permease activity Catalysis of the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in). MF
GO:0015530 shikimate transporter activity Enables the directed movement of shikimate into, out of, within or between cells. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids. MF
GO:0015531 citrate:hydrogen symporter activity Catalysis of the reaction: citrate(out) + H+(out) = citrate(in) + H+(in). MF
GO:0015532 alpha-ketoglutarate:hydrogen symporter activity Catalysis of the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in). MF
GO:0015533 shikimate:hydrogen symporter activity Catalysis of the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in). MF
GO:0015538 sialic acid permease activity Catalysis of the reaction: sialate(out) + H+(out) = sialate(in) + H+(in). MF
GO:0015539 hexuronate porter activity Catalysis of the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate. MF
GO:0019648 formaldehyde assimilation via xylulose monophosphate cycle The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds. BP
GO:0019649 formaldehyde assimilation The pathways in which ammonia is processed and used as a carbon source for the cell. BP
GO:0019642 anaerobic glycolysis NA BP
GO:0019643 reductive tricarboxylic acid cycle A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate. BP
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate. BP
GO:0019641 Embden-Meyerhof pathway The main pathway for anaerobic degradation of carbohydrates. Starch or glycogen is hydrolyzed to glucose 1-phosphate and then through a series of intermediates, yielding two ATP molecules per glucose and producing either pyruvate (which feeds into the tricarboxylic acid cycle) or lactate. BP
GO:0019646 aerobic electron transport The transport of electrons from an electron donor to an electron acceptor which takes place in the presence of oxygen. BP
GO:0019647 formaldehyde assimilation via ribulose monophosphate cycle The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde. BP
GO:0019645 anaerobic electron transport The transport of electrons from an electron donor to an electron acceptor which takes place in the absence of oxygen. BP
GO:0001913 T cell mediated cytotoxicity The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. BP
GO:0001912 positive regulation of leukocyte mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity. BP
GO:0001911 negative regulation of leukocyte mediated cytotoxicity Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity. BP
GO:0001910 regulation of leukocyte mediated cytotoxicity Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. BP
GO:0001917 photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. CC
GO:0001916 positive regulation of T cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. BP
GO:0001915 negative regulation of T cell mediated cytotoxicity Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity. BP
GO:0001914 regulation of T cell mediated cytotoxicity Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. BP
GO:0001919 regulation of receptor recycling Any process that modulates the frequency, rate, or extent of receptor recyling. BP
GO:0001918 farnesylated protein binding Interacting selectively with a farnesylated protein. MF
GO:0030472 mitotic spindle organization and biogenesis in nucleus The formation and maintenance of the spindle in the nucleus, as seen in Fungi during a mitotic cell cycle. BP
GO:0030473 nuclear migration, microtubule-mediated The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. BP
GO:0030474 spindle pole body duplication Construction of a new spindle pole body. BP
GO:0030476 spore wall assembly (sensu Fungi) Process by which the spore nucleus becomes surrounded by a specialized spore wall. Occurs by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0030478 actin cap Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. CC
GO:0030479 actin cortical patch Discrete actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0051219 phosphoprotein binding Interacting selectively with a phosphorylated protein. MF
GO:0051218 tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). BP
GO:0017024 myosin I binding Interacting selectively with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments. MF
GO:0017025 TATA-binding protein binding Interacting selectively with TATA-binding protein (TBP), a component of various transcription factors. MF
GO:0017026 procollagen C-endopeptidase activity Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III. MF
GO:0017020 myosin phosphatase regulator activity Modulation of the activity of the enzyme myosin phosphatase. MF
GO:0017022 myosin binding Interacting selectively with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. MF
GO:0017023 myosin phosphatase complex An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. CC
GO:0047937 glucose-1-phosphate phosphodismutase activity Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate. MF
GO:0047936 glucose 1-dehydrogenase activity Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H. MF
GO:0031703 type 2 angiotensin receptor binding Interacting selectively with a type 2 angiotensin receptor. MF
GO:0047934 glucose 1-dehydrogenase (NAD+) activity Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH. MF
GO:0047933 glucose-1,6-bisphosphate synthase activity Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate. MF
GO:0047932 glucosamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + D-glucosamine = CoA + N-acetyl-D-glucosamine. MF
GO:0031707 endothelin A receptor binding Interacting selectively with an endothelin A receptor. MF
GO:0047930 glucosaminate ammonia-lyase activity Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3. MF
GO:0031709 gastrin-releasing peptide receptor binding Interacting selectively with a gastrin-releasing peptide receptor. MF
GO:0031708 endothelin B receptor binding Interacting selectively with an endothelin B receptor. MF
GO:0047939 L-glucuronate reductase activity Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + NADPH. MF
GO:0047938 glucose-6-phosphate 1-epimerase activity Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. MF
GO:0015888 thiamin transport The directed movement of thiamin into, out of, within or between cells. Thiamin is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. BP
GO:0015889 cobalamin transport The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell. BP
GO:0015884 folic acid transport The directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. BP
GO:0015885 5-formyltetrahydrofolate transport The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells. BP
GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. BP
GO:0015887 pantothenate transport The directed movement of pantothenate into, out of, within or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. BP
GO:0015880 coenzyme A transport The directed movement of coenzyme A into, out of, within or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. BP
GO:0015881 creatine transport The directed movement of creatine into, out of, within or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. BP
GO:0015882 L-ascorbic acid transport The directed movement of L-ascorbic acid into, out of, within or between cells. L-ascorbic acid is a six-carbon carbohydrate-like compound found in fruit and vegetables. It has vitamin C activity in humans and guinea pigs. BP
GO:0015883 FAD transport The directed movement of flavin-adenine dinucleotide (FAD) into, out of, within or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. BP
GO:0021930 granule cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. BP
GO:0021935 granule cell precursor tangential migration The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium. BP
GO:0005229 intracellular calcium activated chloride channel activity NA MF
GO:0005228 intracellular sodium activated potassium channel activity NA MF
GO:0005221 intracellular cyclic nucleotide activated cation channel activity NA MF
GO:0005220 inositol 1,4,5-triphosphate-sensitive calcium-release channel activity NA MF
GO:0005223 intracellular cGMP activated cation channel activity NA MF
GO:0032421 stereocilium bundle An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. CC
GO:0032420 stereocilium An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles. CC
GO:0032423 regulation of mismatch repair Any process that modulates the frequency, rate or extent of mismatch repair. BP
GO:0032422 purine-rich negative regulatory element binding Interacting selectively with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. MF
GO:0032425 positive regulation of mismatch repair Any process that activates or increases the frequency, rate or extent of mismatch repair. BP
GO:0032424 negative regulation of mismatch repair Any process that stops, prevents or reduces the frequency, rate or extent of mismatch repair. BP
GO:0032427 GBD domain binding Interacting selectively with the GBD (GTPase protein binding domain) domain of small GTPases. MF
GO:0032426 stereocilium bundle tip The end of a stereocilium bundle, distal to the site of the bundle's attachment to the apical cell surface. CC
GO:0032429 regulation of phospholipase A2 activity Any process that modulates the activity of the enzyme phospholipase A2. BP
GO:0032428 beta-N-acetylgalactosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides. MF
GO:0005224 ATP-binding and phosphorylation-dependent chloride channel activity NA MF
GO:0005227 calcium activated cation channel activity NA MF
GO:0008574 plus-end-directed microtubule motor activity Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP (or GTP). MF
GO:0008579 JUN kinase phosphatase activity NA MF
GO:0045395 positive regulation of interleukin-22 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22. BP
GO:0045394 negative regulation of interleukin-22 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22. BP
GO:0045397 negative regulation of interleukin-23 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23. BP
GO:0045396 regulation of interleukin-23 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23. BP
GO:0045391 negative regulation of interleukin-21 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21. BP
GO:0045390 regulation of interleukin-21 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21. BP
GO:0045393 regulation of interleukin-22 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22. BP
GO:0045392 positive regulation of interleukin-21 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21. BP
GO:0045399 regulation of interleukin-3 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3. BP
GO:0045398 positive regulation of interleukin-23 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23. BP
GO:0045649 regulation of macrophage differentiation Any process that modulates the frequency, rate or extent of macrophage differentiation. BP
GO:0045648 positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. BP
GO:0045647 negative regulation of erythrocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte differentiation. BP
GO:0045646 regulation of erythrocyte differentiation Any process that modulates the frequency, rate or extent of erythrocyte differentiation. BP
GO:0045645 positive regulation of eosinophil differentiation Any process that activates or increases the frequency, rate or extent of eosinophil differentiation. BP
GO:0045644 negative regulation of eosinophil differentiation Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil differentiation. BP
GO:0045643 regulation of eosinophil differentiation Any process that modulates the frequency, rate or extent of eosinophil differentiation. BP
GO:0045642 positive regulation of basophil differentiation Any process that activates or increases the frequency, rate or extent of basophil differentiation. BP
GO:0045641 negative regulation of basophil differentiation Any process that stops, prevents or reduces the frequency, rate or extent of basophil differentiation. BP
GO:0045640 regulation of basophil differentiation Any process that modulates the frequency, rate or extent of basophil differentiation. BP
GO:0042387 plasmatocyte differentiation The processes by which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response. BP
GO:0042386 hemocyte differentiation (sensu Arthropoda) The process whereby a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0042385 myosin III complex A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain. CC
GO:0042384 cilium biogenesis The assembly of a cilium, a specialized eukaryotic locomotor organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. BP
GO:0042383 sarcolemma The outer membrane of a muscle fiber, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. CC
GO:0042382 paraspeckles Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. CC
GO:0042381 hemolymph coagulation The processes by which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response. BP
GO:0042380 hydroxymethylbutenyl pyrophosphate reductase activity Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate. MF
GO:0042389 omega-3 fatty acid desaturase activity Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain. MF
GO:0042388 gibberellic acid mediated signaling, G-alpha-dependent A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. BP
GO:0030869 RENT complex A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit. CC
GO:0030868 smooth endoplasmic reticulum membrane The lipid bilayer surrounding the smooth endoplasmic reticulum. CC
GO:0030863 cortical cytoskeleton The portion of the cytoskeleton that lies just beneath the plasma membrane. CC
GO:0030862 positive regulation of polarized epithelial cell differentiation Any process that activates or increases the rate or extent of polarized epithelial cell differentiation. BP
GO:0030861 negative regulation of polarized epithelial cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of polarized epithelial cell differentiation. BP
GO:0030860 regulation of polarized epithelial cell differentiation Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation. BP
GO:0030867 rough endoplasmic reticulum membrane The lipid bilayer surrounding the rough endoplasmic reticulum. CC
GO:0030866 cortical actin cytoskeleton organization and biogenesis The assembly and arrangement of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. BP
GO:0030865 cortical cytoskeleton organization and biogenesis The assembly and arrangement of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. BP
GO:0030864 cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. CC
GO:0050809 diazepam binding Interacting selectively with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium. MF
GO:0050808 synapse organization and biogenesis The assembly and arrangement of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). BP
GO:0050803 regulation of synapse structure and activity Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). BP
GO:0050802 circadian sleep/wake cycle, sleep The part of the circadian sleep/wake cycle where the organism is asleep. BP
GO:0050801 ion homeostasis Any of the processes involved in the maintenance of an internal equilibrium of ions within an organism or cell. BP
GO:0050807 regulation of synapse structure Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). BP
GO:0050806 positive regulation of synaptic transmission Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. BP
GO:0050805 negative regulation of synaptic transmission Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. BP
GO:0050804 regulation of synaptic transmission Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. BP
GO:0046606 negative regulation of centrosome cycle Any process that stops, prevents or reduces the frequency, rate or extent of the centrosome cycle. BP
GO:0046607 positive regulation of centrosome cycle Any process that activates or increases the frequency, rate or extent of the centrosome cycle. BP
GO:0046604 positive regulation of mitotic centrosome separation Any process that activates or increases the frequency, rate or extent of centrosome separation. BP
GO:0046605 regulation of centrosome cycle Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. BP
GO:0046602 regulation of mitotic centrosome separation Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis. BP
GO:0046603 negative regulation of mitotic centrosome separation Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation. BP
GO:0046600 negative regulation of centriole replication Any process that stops, prevents or reduces the frequency, rate or extent of centriole replication. BP
GO:0046601 positive regulation of centriole replication Any process that activates or increases the frequency, rate or extent of centriole replication. BP
GO:0046608 carotenoid isomerase activity Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids. MF
GO:0046609 voltage-gated sulfate antiporter activity NA MF
GO:0030139 endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. CC
GO:0030131 clathrin adaptor complex A membrane adaptor complex that links clathrin to a membrane. CC
GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. CC
GO:0030133 transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, and to destinations within or outside the cell. CC
GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. CC
GO:0030135 coated vesicle Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. CC
GO:0030134 ER to Golgi transport vesicle A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. CC
GO:0030137 COPI-coated vesicle A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. CC
GO:0030136 clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. CC
GO:0004479 methionyl-tRNA formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. MF
GO:0004478 methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. MF
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate. MF
GO:0004471 malate dehydrogenase (decarboxylating) activity Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate. MF
GO:0004470 malic enzyme activity Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. MF
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. MF
GO:0004476 mannose-6-phosphate isomerase activity Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. MF
GO:0004475 mannose-1-phosphate guanylyltransferase activity Catalysis of the reaction: GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose. MF
GO:0004474 malate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + glyoxylate = L-malate + CoA. MF
GO:0048068 adult cuticle pigmentation (sensu Insecta) Establishment of the adult pattern of pigmentation in the cuticle of an organism. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048069 eye pigmentation Establishment of a pattern of pigment in the eye of an organism. BP
GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. BP
GO:0006908 clathrin-independent pinocytosis NA BP
GO:0008961 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity NA MF
GO:0006904 vesicle docking during exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during exocytosis. BP
GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. MF
GO:0008962 phosphatidylglycerophosphatase activity Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. MF
GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. MF
GO:0008964 phosphoenolpyruvate carboxylase activity Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2. MF
GO:0006903 vesicle targeting The process by which vesicles are directed to specific destination membranes, mediated by microtubules that grow between molecules at the vesicle membrane and target membrane surfaces. BP
GO:0008966 phosphoglucosamine mutase activity Catalysis of the reaction: D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. MF
GO:0042602 flavin reductase activity Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + H+. MF
GO:0042603 capsule A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules play an important role in pathogenicity, preventing phagocytosis by eukaryotic cells. CC
GO:0042600 chorion A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish. CC
GO:0042601 forespore (sensu Bacteria) Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0042606 endogenous peptide antigen binding Interacting selectively with an antigen peptide, a fragment of an endogenous foreign protein, derived by proteolysis within the cell. MF
GO:0042607 exogenous peptide antigen binding Interacting selectively with an antigen peptide, a fragment of an exogenous foreign protein derived by endocytosis of the protein and proteolysis within the cell. MF
GO:0042604 capsule (sensu Fungi) A protective structure attached externally to the cell wall and composed primarily of polysaccharides. Capsules play an important role in pathogenicity, preventing phagocytosis by eukaryotic cells. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0042605 peptide antigen binding Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. MF
GO:0042608 T cell receptor binding Interacting selectively with a T cell receptor, the antigen-recognizing receptor on the surface of T cells. MF
GO:0042609 CD4 receptor binding Interacting selectively with a CD4, a receptor found on the surface of T cells, monocytes and macrophages. MF
GO:0050586 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity Catalysis of the reaction: 3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = N-acetylanthranilate + CO. MF
GO:0050587 chlorite O2-lyase activity Catalysis of the reaction: O2 + Cl- = chlorite. MF
GO:0018759 methenyltetrahydromethanopterin cyclohydrolase activity Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N5-formyl-5,6,7,8-tetrahydromethanopterin. MF
GO:0050585 4-hydroxymandelate synthase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2. MF
GO:0050582 xylitol oxidase activity Catalysis of the reaction: xylitol + O2 = xylose + H2O2. MF
GO:0050583 hydrogen dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + H2 = NADPH + H+. MF
GO:0050580 2,5-didehydrogluconate reductase activity Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+. MF
GO:0050581 D-mannitol oxidase activity Catalysis of the reaction: mannitol + O2 = mannose + H2O2. MF
GO:0018753 cyanuric acid amidohydrolase activity Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2. MF
GO:0018752 epsilon-caprolactam lactamase activity Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate. MF
GO:0018751 3,5-dichlorophenylcarboximide hydrolase activity Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate. MF
GO:0018750 biuret amidohydrolase activity Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3. MF
GO:0018757 deisopropylhydroxyatrazine aminohydrolase activity Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine. MF
GO:0018756 ammeline aminohydrolase activity Catalysis of the reaction: ammeline + H2O = ammelide + NH3. MF
GO:0018755 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity NA MF
GO:0018754 ammelide aminohydrolase activity Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3. MF
GO:0021537 telencephalon development The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. BP
GO:0019089 transmission of virus The transfer of virions in order to create new infection. BP
GO:0021535 cell migration in hindbrain The orderly movement of cells that will reside in the hindbrain. BP
GO:0021534 cell proliferation in hindbrain The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population in the hindbrain. BP
GO:0021533 cell differentiation in hindbrain The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021532 neural tube patterning The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. BP
GO:0021531 radial glial cell differentiation in the spinal cord The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. BP
GO:0021530 spinal cord oligodendrocyte cell fate specification The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. BP
GO:0019080 viral genome expression The achievement of highly specific, quantitative, temporal and spatial control of virus gene expression within the limited genetic resources of the viral genome. BP
GO:0019081 viral protein biosynthetic process The chemical reactions and pathways resulting in the formation of viral proteins. BP
GO:0019082 viral protein processing The posttranslational processing of viral proteins. BP
GO:0019083 viral transcription The mechanisms involved in viral gene transcription, especially referring to those with temporal properties unique to viral transcription. BP
GO:0019084 (delayed) early viral mRNA transcription The second round of viral gene transcription; most genes transcribed in this round are necessary for genome replication. BP
GO:0019085 immediate early viral mRNA transcription The transcriptional period of the earliest expressed viral genes, mainly encoding transcriptional regulators. BP
GO:0021539 subthalamus development The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis. BP
GO:0021538 epithalamus development The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle. BP
GO:0050058 linoleate isomerase activity Catalysis of the reaction: 9-cis,12-cis-octadecadienoate = 9-cis,11-trans-octadecadienoate. MF
GO:0050059 lombricine kinase activity Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine. MF
GO:0050050 leucine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + L-leucine = CoA + N-acetyl-L-leucine. MF
GO:0050051 leukotriene-B4 20-monooxygenase activity Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O. MF
GO:0050052 leukotriene-E4 20-monooxygenase activity Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leucotriene E4 + NADP+ + H2O. MF
GO:0050053 levansucrase activity Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1). MF
GO:0050054 lignostilbene alpha beta-dioxygenase activity Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethene + O2 = 2 vanillin. MF
GO:0050055 limonin-D-ring-lactonase activity Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate. MF
GO:0050056 linalool 8-monooxygenase activity Catalysis of the reaction: 3,7-dimethylocta-1,6-dien-3-ol + donor-H2 + O2 = (E)-3,7-dimethylocta-1,6-dien-3,8-diol + acceptor + H2O. MF
GO:0050057 linamarin synthase activity Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin. MF
GO:0007359 posterior abdomen determination The regionalization process by which the posterior (abdominal) regions of the embryo are specified by the gap genes. BP
GO:0007358 establishment of central gap gene boundaries Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel. BP
GO:0007352 zygotic determination of dorsal/ventral axis The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote. BP
GO:0007351 tripartite regional subdivision Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. BP
GO:0007350 blastoderm segmentation The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. BP
GO:0007357 positive regulation of central gap gene transcription The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products. BP
GO:0007356 thorax and anterior abdomen determination Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product. BP
GO:0007355 anterior region determination Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product. BP
GO:0007354 zygotic determination of anterior/posterior axis, embryo The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade. BP
GO:0048511 rhythmic process Those processes pertinent to the generation and maintenance of rhythms in the physiology of an organism. BP
GO:0008356 asymmetric cell division The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. BP
GO:0002871 regulation of natural killer cell tolerance induction Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction. BP
GO:0002870 T cell anergy Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction. BP
GO:0002873 positive regulation of natural killer cell tolerance induction Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction. BP
GO:0002872 negative regulation of natural killer cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction. BP
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. BP
GO:0002874 regulation of chronic inflammatory response to antigenic stimulus Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. BP
GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. BP
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus. BP
GO:0052348 positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052347 positive regulation by symbiont of defense-related host nitric oxide production Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052344 positive regulation by symbiont of host phytoalexin production Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052345 positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052342 catabolism by organism of cell wall chitin in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052340 catabolism by organism of cell wall cellulose in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052341 catabolism by organism of cell wall pectin in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0009733 response to auxin stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. BP
GO:0032356 oxidized DNA binding Interacting selectively with oxidized residues in DNA. MF
GO:0009731 detection of sucrose stimulus The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal. BP
GO:0009730 detection of carbohydrate stimulus The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal. BP
GO:0009737 response to abscisic acid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. BP
GO:0009736 cytokinin mediated signaling A series of molecular signals induced by the detection of cytokinin. BP
GO:0009735 response to cytokinin stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus. BP
GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. BP
GO:0005463 UDP-N-acetylgalactosamine transporter activity Enables the directed movement of N-acetylgalactosamine into, out of, within or between cells. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. MF
GO:0005462 UDP-N-acetylglucosamine transporter activity Enables the directed movement of UDP-N-acetylglucosamine into, out of, within or between cells. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. MF
GO:0005461 UDP-glucuronic acid transporter activity Enables the directed movement of UDP-glucuronic acid into, out of, within or between cells. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. MF
GO:0005460 UDP-glucose transporter activity Enables the directed movement of UDP-glucose into, out of, within or between cells. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate. MF
GO:0005464 UDP-xylose transporter activity Enables the directed movement of UDP-xylose into, out of, within or between cells. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. MF
GO:0005469 succinate:fumarate antiporter activity Catalysis of the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out). MF
GO:0005103 baboon binding Interacting selectively with the baboon (babo) protein, a type I transforming growth factor beta receptor. MF
GO:0016944 RNA polymerase II transcription elongation factor activity Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation. MF
GO:0016945 RNA polymerase III transcription elongation factor activity Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation. MF
GO:0016946 cathepsin F activity Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2. MF
GO:0016947 N5,N10-methylenetetrahydromethanopterin dehydrogenase activity Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin + 2 H+. MF
GO:0016941 natriuretic peptide receptor activity NA MF
GO:0016942 insulin-like growth factor binding protein complex A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. CC
GO:0016943 RNA polymerase I transcription elongation factor activity Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation. MF
GO:0016948 iron hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. Iron-sulfur-containing hydrogenase ((Fe) hydrogenase) with two ferredoxin-type (4Fe-4S) clusters and an atypical iron-sulfur center believed to be involved in the activation of H2. The (Fe) hydrogenase has the highest specific activity in the evolution and consumption of hydrogen and in the proton-deuterium exchange reaction and this enzyme is the most sensitive to CO and nitrite (NO2(-)). MF
GO:0016949 nickel hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. MF
GO:0047717 imidazoleacetate 4-monooxygenase activity Catalysis of the reaction: 4-imidazoleacetate + NADH + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O. MF
GO:0047716 imidazole N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + imidazole = CoA + N-acetylimidazole. MF
GO:0047715 hypotaurocyamine kinase activity Catalysis of the reaction: hypotaurocyamine + ATP = N(omega)-phosphohypotaurocyamine + ADP. MF
GO:0047714 galactolipase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. MF
GO:0047713 galactitol 2-dehydrogenase activity Catalysis of the reaction: galactitol + NAD+ = D-tagatose + NADH. MF
GO:0047712 Cypridina-luciferin 2-monooxygenase activity Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light. MF
GO:0015763 N-acetylgalactosamine transport The directed movement of N-acetylgalactosamine into, out of, within or between cells. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. BP
GO:0047710 bis(5'-adenosyl)-triphosphatase activity Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP. MF
GO:0015769 melibiose transport The directed movement of melibiose into, out of, within or between cells. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. BP
GO:0015768 maltose transport The directed movement of maltose into, out of, within or between cells. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch. BP
GO:0047719 indole 2,3-dioxygenase activity Catalysis of the reaction: indole + O2 = 2-formylaminobenzaldehyde. MF
GO:0047718 indanol dehydrogenase activity Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. MF
GO:0043407 negative regulation of MAPK activity Any process that stops, prevents or reduces the frequency, rate or extent of MAP kinase activity. BP
GO:0043406 positive regulation of MAPK activity Any process that activates or increases the frequency, rate or extent of MAP kinase activity. BP
GO:0043405 regulation of MAPK activity Any process that modulates the frequency, rate or extent of MAP kinase activity. BP
GO:0043404 corticotropin-releasing hormone receptor activity Combining with corticotropin-releasing hormone to initiate a change in cell activity. MF
GO:0043403 skeletal muscle regeneration The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. BP
GO:0043402 glucocorticoid mediated signaling A series of molecular signals mediated by the detection of a glucocorticoid hormone. BP
GO:0043401 steroid hormone mediated signaling A series of molecular signals mediated by the detection of a steroid hormone. BP
GO:0043400 cortisol secretion The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland. BP
GO:0016496 substance P receptor activity Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. MF
GO:0016497 substance K receptor activity Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity. MF
GO:0016494 C-X-C chemokine receptor activity Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. MF
GO:0016495 C-X3-C chemokine receptor activity Combining with a C-X3-C chemokine to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif. MF
GO:0016492 neurotensin receptor activity, G-protein coupled G-protein coupled receptor for the tridecapeptide neurotensin. Associated with G-protein signaling, coupled to IP3 second messenger (phospholipase C activating). MF
GO:0016493 C-C chemokine receptor activity Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. MF
GO:0043409 negative regulation of MAPKKK cascade Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. BP
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. MF
GO:0021678 third ventricle development The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina. BP
GO:0021679 cerebellar molecular layer development The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. BP
GO:0021674 rhombomere 8 morphogenesis The process by which the anatomical structure of rhombomere 8 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021675 nerve development The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. BP
GO:0021676 rhombomere 8 structural organization The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021677 rhombomere 8 formation The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0021670 lateral ventricle development The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. BP
GO:0021671 rhombomere 7 morphogenesis The process by which the anatomical structure of rhombomere 7 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021672 rhombomere 7 structural organization The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. BP
GO:0021673 rhombomere 7 formation The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. BP
GO:0016238 chaperone-mediated autophagy NA BP
GO:0016239 positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. BP
GO:0016232 HNK-1 sulfotransferase activity Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R). MF
GO:0016233 telomere capping A process by which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. BP
GO:0016230 sphingomyelin phosphodiesterase activator activity Increases the activity of the enzyme sphingomyelin phosphodiesterase. MF
GO:0016231 beta-N-acetylglucosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. MF
GO:0016236 macroautophagy The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. BP
GO:0016237 microautophagy The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment. BP
GO:0016234 inclusion body Intracellular foci at which aggregated proteins have been sequestered. CC
GO:0016235 aggresome An inclusion body resulting from dynein-dependent retrograde transport of an aggregated protein on microtubules. CC
GO:0046044 TMP metabolic process The chemical reactions and pathways involving TMP, ribosylthymine monophosphate. BP
GO:0046045 TMP catabolic process The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate. BP
GO:0046046 TTP metabolic process The chemical reactions and pathways involving TTP, ribosylthymine triphosphate. BP
GO:0046047 TTP catabolic process The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate. BP
GO:0046040 IMP metabolic process The chemical reactions and pathways involving IMP, inosine monophosphate. BP
GO:0046041 ITP metabolic process The chemical reactions and pathways involving ITP, inosine triphosphate. BP
GO:0046042 ITP biosynthetic process The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate. BP
GO:0046043 TDP metabolic process The chemical reactions and pathways involving TDP, ribosylthymine diphosphate. BP
GO:0046048 UDP metabolic process The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate. BP
GO:0046049 UMP metabolic process The chemical reactions and pathways involving UMP, uridine monophosphate. BP
GO:0008890 glycine C-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate. MF
GO:0045029 UDP-activated nucleotide receptor activity NA MF
GO:0045028 purinergic nucleotide receptor activity, G-protein coupled NA MF
GO:0045027 DNA end binding Interacting selectively with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs). MF
GO:0045026 plasma membrane fusion The joining of two or more lipid bilayer membranes that surround a cell. BP
GO:0045025 mitochondrial degradosome The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts. CC
GO:0045024 peptidyl-glutamyl peptide hydrolyzing enzyme activity Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids. MF
GO:0045023 G0 to G1 transition The transition from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. BP
GO:0045022 early endosome to late endosome transport The directed movement of substances, in membrane bound vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. BP
GO:0045021 error-free DNA repair DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways. BP
GO:0045020 error-prone DNA repair DNA repair pathways that tend to increase the endogenous mutation rate. BP
GO:0047872 dolichol O-acyltransferase activity Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate. MF
GO:0047873 dolichyl-phosphatase activity Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate. MF
GO:0047870 discadenine synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + N6-(D2-isopentenyl)-adenine = 5'-methylthioadenosine + discadenine. MF
GO:0047871 disulfoglucosamine-6-sulfatase activity Catalysis of the reaction: N,6-O-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + SO4(2-) (sulfate). MF
GO:0047876 endoglycosylceramidase activity Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose. MF
GO:0047877 ephedrine dehydrogenase activity Catalysis of the reaction: (-)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH. MF
GO:0047874 dolichyldiphosphatase activity Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. MF
GO:0047875 ecdysone oxidase activity Catalysis of the reaction: ecdysone + O2 = 3-dehydroecdysone + H2O2. MF
GO:0047878 erythritol kinase activity Catalysis of the reaction: ATP + erythritol = ADP + D-erythritol 4-phosphate. MF
GO:0047879 erythronolide synthase activity Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B. MF
GO:0031576 G2/M transition checkpoint Any cell cycle checkpoint that blocks entry into M phase. BP
GO:0031577 spindle checkpoint A cell cycle checkpoint that delays the metaphase/anaphase transition until all chromosomes are attached to the spindle. BP
GO:0031574 S-M checkpoint A cell cycle checkpoint which halts replication in response to nucleotide depletion. BP
GO:0031575 G1/S transition checkpoint Any cell cycle checkpoint that blocks entry into S phase. BP
GO:0031572 G2/M transition DNA damage checkpoint A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage. BP
GO:0031573 intra-S DNA damage checkpoint The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession. BP
GO:0031570 DNA integrity checkpoint Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. BP
GO:0031571 G1 DNA damage checkpoint A cell cycle checkpoint that arrests cell cycle progression G1 phase in response to DNA damage. BP
GO:0031578 spindle orientation checkpoint A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected. BP
GO:0031579 lipid raft organization and biogenesis The assembly and arrangement of lipid rafts, tightly-packed gel-like membrane microdomains enriched in sphingolipids and cholesterol. BP
GO:0009548 plasmodesmatal plasma membrane NA CC
GO:0009549 cellulose microfibril Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the protoplast. CC
GO:0009544 chloroplast ATP synthase complex The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts. CC
GO:0009545 elaioplast A leucoplast in which oil is stored. CC
GO:0009546 plasmodesmatal cytoplasmic sleeve NA CC
GO:0009547 plastid ribosome A ribosome contained within a plastid. CC
GO:0009540 zeaxanthin epoxidase activity Catalysis of the conversion of zeaxanthin to antheraxanthin and violaxanthin. MF
GO:0009541 etioplast prolamellar body A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast. CC
GO:0009542 granum Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis. CC
GO:0009543 thylakoid lumen (sensu Viridiplantae) A cavity enclosed within the thylakoid membrane. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0046835 carbohydrate phosphorylation The process of introducing a phosphoric group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. BP
GO:0046834 lipid phosphorylation The process of introducing one or more phosphoric groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. BP
GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. BP
GO:0046831 regulation of RNA export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm. BP
GO:0046830 positive regulation of RNA import into nucleus Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus. BP
GO:0046833 positive regulation of RNA export from nucleus Any process that activates or increases the frequency, rate or extent of firected movement of RNA from the nucleus into the cytoplasm. BP
GO:0046832 negative regulation of RNA export from nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm. BP
GO:0046839 phospholipid dephosphorylation The process of removing one or more phosphoric groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. BP
GO:0046838 phosphorylated carbohydrate dephosphorylation The process of removing a phosphoric group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate moiety attached to it. BP
GO:0021698 cerebellar cortex structural organization The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. BP
GO:0016748 succinyltransferase activity Catalysis of the transfer of an succinyl (3-carboxypropanoyl) group to an acceptor molecule. MF
GO:0016749 N-succinyltransferase activity Catalysis of the transfer of an succinyl group to a nitrogen atom on the acceptor molecule. MF
GO:0045568 positive regulation of TRAIL receptor 2 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2. BP
GO:0045569 TRAIL binding Interacting selectively with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. MF
GO:0045562 regulation of TRAIL receptor 2 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2. BP
GO:0045563 negative regulation of TRAIL receptor biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. BP
GO:0045560 regulation of TRAIL receptor biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. BP
GO:0045561 regulation of TRAIL receptor 1 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1. BP
GO:0045566 positive regulation of TRAIL receptor 1 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1. BP
GO:0045567 negative regulation of TRAIL receptor 2 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2. BP
GO:0045564 positive regulation of TRAIL receptor biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor. BP
GO:0045565 negative regulation of TRAIL receptor 1 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1. BP
GO:0042022 interleukin-12 receptor complex Complex that binds interleukin-12; comprises an alpha and a beta subunit. CC
GO:0042023 DNA endoreduplication Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. For example, occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes. BP
GO:0042020 interleukin-23 receptor activity Combining with interleukin-23 to initiate a change in cell activity. MF
GO:0042021 granulocyte macrophage colony-stimulating factor complex binding Interacting selectively with the granulocyte macrophage colony-stimulating factor complex. MF
GO:0047058 vitamin-K-epoxide reductase (warfarin-insensitive) activity Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. MF
GO:0047059 polyvinyl-alcohol dehydrogenase (acceptor) activity Catalysis of the reaction: acceptor + polyvinyl alcohol = donor-H2 + oxidized polyvinyl alcohol. MF
GO:0042024 DNA endoreduplication initiation The reinitiation of DNA replication within a single cell cycle. BP
GO:0042025 host cell nucleus The nucleus of a host cell. CC
GO:0047054 berbamunine synthase activity Catalysis of the reaction: O2 + NADPH + H+ + R-N-methylcoclaurine + S-N-methylcoclaurine = 2 H2O + NADP+ + berbamunine. MF
GO:0047055 salutaridine synthase activity Catalysis of the reaction: O2 + NADPH + H+ + (R)-reticuline = 2 H2O + NADP+ + salutaridine. MF
GO:0047056 (S)-canadine synthase activity Catalysis of the reaction: O2 + NADPH + H+ + S-tetrahydrocolumbamine = 2 H2O + NADP+ + S-canadine. MF
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. MF
GO:0047050 (S)-2-hydroxy-fatty-acid dehydrogenase activity Catalysis of the reaction: NAD+ + (S)-2-hydroxystearate = NADH + H+ + 2-oxostearate. MF
GO:0047051 D-lactate dehydrogenase (cytochrome c-553) activity Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate. MF
GO:0047052 (S)-stylopine synthase activity Catalysis of the reaction: O2 + NADPH + H+ + S-cheilanthifoline = 2 H2O + NADP+ + S-stylopine. MF
GO:0047053 (S)-cheilanthifoline synthase activity Catalysis of the reaction: O2 + NADPH + H+ + S-scoulerine = 2 H2O + NADP+ + S-cheilanthifoline. MF
GO:0006310 DNA recombination The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. BP
GO:0006311 meiotic gene conversion The cell cycle process whereby genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele. BP
GO:0006312 mitotic recombination The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. BP
GO:0006313 transposition, DNA-mediated Any process involved in a type of transpositional recombination which occurs via a DNA intermediate. BP
GO:0006314 intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. BP
GO:0006315 homing of group II introns Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure. BP
GO:0006316 movement of group I intron Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction. BP
GO:0031969 chloroplast membrane Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope. CC
GO:0031968 organelle outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of an organelle envelope. CC
GO:0031961 cortisol receptor binding Interacting selectively with a cortisol receptor. MF
GO:0031960 response to corticosteroid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. BP
GO:0031963 cortisol receptor activity Combining with cortisol to initiate a change in cell activity. MF
GO:0031962 mineralocorticoid receptor binding Interacting selectively with a mineralocorticoid receptor. MF
GO:0031965 nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. CC
GO:0031964 beta-alanyl-histamine hydrolase activity Catalysis of the conversion of beta-alanyl-histamine to histamine. MF
GO:0031967 organelle envelope A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. CC
GO:0031966 mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. CC
GO:0050638 taxadien-5-alpha-ol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5-alpha-ol = CoA + taxa-4(20),11-dien-5-alpha-yl acetate. MF
GO:0050639 10-hydroxytaxane O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C. MF
GO:0050630 (iso)eugenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol. MF
GO:0050631 corydaline synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+. MF
GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA. MF
GO:0050633 acetyl-CoA C-myristoyltransferase activity Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA. MF
GO:0050634 phloroisovalerophenone synthase activity Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one. MF
GO:0050635 acridone synthase activity Catalysis of the reaction: 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2. MF
GO:0050636 vinorine synthase activity Catalysis of the reaction: acetyl-CoA + 16-epivellosimine = CoA + vinorine. MF
GO:0050637 lovastatin nonaketide synthase activity Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O. MF
GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. CC
GO:0005662 DNA replication factor A complex A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. CC
GO:0005665 DNA-directed RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. CC
GO:0005664 nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. CC
GO:0005667 transcription factor complex Any complex, distinct from RNA polymerase, including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences, and regulating transcription. CC
GO:0005666 DNA-directed RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. CC
GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. CC
GO:0005668 selectivity factor SL1 complex A RNA polymerase I-specific protein complex which in humans has two subunits, tata-binding protein (TBP) and TBP-associated factor 1 (TAF1). CC
GO:0035088 establishment and/or maintenance of apical/basal cell polarity Polarization of a cells architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. BP
GO:0035089 establishment of apical/basal cell polarity The specification and formation of the polarity of a cell along its apical/basal axis. BP
GO:0035082 axoneme biogenesis The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements. BP
GO:0035083 cilium axoneme biogenesis The assembly and organization of a the bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements. BP
GO:0035080 heat shock-mediated polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus. BP
GO:0035081 induction of programmed cell death by hormones Any process induced by hormones that directly activates any of the steps required for programmed cell death. BP
GO:0035086 flagellar axoneme The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements. CC
GO:0035087 RNA interference, siRNA loading onto RISC The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC). BP
GO:0035084 flagellum axoneme biogenesis The assembly and organization of a the bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements. BP
GO:0035085 cilium axoneme The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements. CC
GO:0002365 gamma-delta T cell lineage commitment The process by which a pro-T cell becomes committed to becoming a gamma-delta T cell. BP
GO:0002364 NK T cell lineage commitment The process by which a pro-T cell becomes committed to becoming an NK T cell. BP
GO:0002367 cytokine production during immune response The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002366 leukocyte activation during immune response A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. BP
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell. BP
GO:0002360 T cell lineage commitment The process by which a lymphoid progenitor cell becomes committed to becoming any type of T cell. BP
GO:0002363 alpha-beta T cell lineage commitment The process by which a pro-T cell becomes committed to becoming an alpha-beta T cell. BP
GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment The process by which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell. BP
GO:0002369 T cell cytokine production Any process that contributes to cytokine production by a T cell. BP
GO:0002368 B cell cytokine production Any process that contributes to cytokine production by a B cell. BP
GO:0004370 glycerol kinase activity Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate. MF
GO:0042470 melanosome A tissue-specific, membrane bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. CC
GO:0052566 response to host phytoalexin production A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052567 response to defense-related host reactive oxygen species production A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen speciesc produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052564 response to immune response of other organism during symbiotic interaction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052565 response to defense-related host nitric oxide production A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052562 negative regulation by symbiont of host immune response Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042473 outer ear morphogenesis The process by which the anatomical structures of the outer ear are generated and organized. Morphogenesis pertains to the creation of form. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull. BP
GO:0052561 negative regulation by organism of immune response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. BP
GO:0004373 glycogen (starch) synthase activity Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). MF
GO:0003968 RNA-directed RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA (n) = diphosphate + RNA (n+1); uses an RNA template. MF
GO:0003969 RNA editase activity NA MF
GO:0003964 RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. MF
GO:0003960 NADPH:quinone reductase activity Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. MF
GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. MF
GO:0003962 cystathionine gamma-synthase activity Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. MF
GO:0004375 glycine dehydrogenase (decarboxylating) activity Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. MF
GO:0019479 L-alanine oxidation to propanoate NA BP
GO:0042477 odontogenesis (sensu Protostomia) The process whose specific outcome is the progression of a tooth over time, from its formation to the mature structure. A tooth is any hard calcareous or chitinous organ found in the mouth and used in feeding or procuring food, e.g. a mollusk or starfish tooth. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0019475 L-lysine catabolic process to acetate The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate. BP
GO:0019474 L-lysine catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA. BP
GO:0019477 L-lysine catabolic process The chemical reactions and pathways resulting in the breakdown of L-lysine, the levorotatory isomer of (S)-2,6-diaminohexanoic acid. BP
GO:0019476 D-lysine catabolic process The chemical reactions and pathways resulting in the breakdown of D-lysine, the dextrorotatory isomer of (S)-2,6-diaminohexanoic acid. BP
GO:0019471 4-hydroxyproline metabolic process The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. BP
GO:0019470 4-hydroxyproline catabolic process The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. BP
GO:0019473 L-lysine catabolic process to glutarate, by acetylation The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation. BP
GO:0019472 4-hydroxyproline biosynthetic process The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. BP
GO:0042813 Wnt receptor activity Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity. MF
GO:0042812 pheromone catabolic process The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. BP
GO:0042811 pheromone biosynthetic process The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. BP
GO:0042810 pheromone metabolic process The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. BP
GO:0042817 pyridoxal metabolic process The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. BP
GO:0042816 vitamin B6 metabolic process The chemical reactions and pathways involving any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. BP
GO:0042815 bipolar cell growth Simultaneous polarized growth from opposite ends of a cell. BP
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. MF
GO:0042819 vitamin B6 biosynthetic process The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. BP
GO:0042818 pyridoxamine metabolic process The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. BP
GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. BP
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter. BP
GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. BP
GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. BP
GO:0000437 negative regulation of transcription from RNA polymerase II promoter by carbon catabolites Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. BP
GO:0000436 positive regulation of transcription from RNA polymerase II promoter by carbon catabolites Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. BP
GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter. BP
GO:0000434 negative regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. BP
GO:0031374 cytosolic type I fatty acid synthase complex A cytosolic fatty acid synthase complex in which each polypeptide chain contains several different catalytic sites. CC
GO:0019299 rhamnose metabolic process The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. BP
GO:0019298 coenzyme B biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. BP
GO:0019291 tyrosine biosynthetic process from chorismate via L-phenylalanine The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate phenylalanine. BP
GO:0019290 siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. BP
GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine. BP
GO:0019292 tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate. BP
GO:0019295 coenzyme M biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. BP
GO:0019294 ketodeoxyoctanoate biosynthetic process The chemical reactions and pathways resulting in the formation of ketodeoxyoctanoate, 2-keto-3-deoxy-D-octaonate, an acid present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. BP
GO:0019297 coenzyme B metabolic process The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. BP
GO:0019296 coenzyme M metabolic process The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. BP
GO:0046022 positive regulation of transcription from RNA polymerase II promoter, mitotic Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis. BP
GO:0051714 positive regulation of cytolysis of cells of another organism Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism. BP
GO:0051715 cytolysis of cells of another organism The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm. BP
GO:0051716 cellular response to stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. BP
GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. MF
GO:0051710 regulation of cytolysis of cells of another organism Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism. BP
GO:0051711 negative regulation of killing of cells of another organism Any process that stops, prevents or reduces the frequency, rate or extent of the killing by an organism of cells in another organism. BP
GO:0051712 positive regulation of killing of cells of another organism Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism. BP
GO:0051713 negative regulation of cytolysis of cells of another organism Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cytolysis of cells in another organism. BP
GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpG. MF
GO:0051719 DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN. MF
GO:0046302 2-chloro-N-isopropylacetanilide catabolic process The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants. BP
GO:0004349 glutamate 5-kinase activity Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. MF
GO:0004348 glucosylceramidase activity Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. MF
GO:0047524 16-hydroxysteroid epimerase activity Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid. MF
GO:0047525 2'-hydroxydaidzein reductase activity Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzen + NADPH + H+. MF
GO:0047526 2'-hydroxyisoflavone reductase activity Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+. MF
GO:0047527 2,3-dihydroxybenzoate-serine ligase activity Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine. MF
GO:0047520 11-cis-retinyl-palmitate hydrolase activity Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + palmitate. MF
GO:0047521 12-beta-hydroxysteroid dehydrogenase activity Catalysis of the reaction: 3-alpha,7-alpha,12-beta-trihydroxy-5-beta-cholanate + NADP+ = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + NADPH + H+. MF
GO:0047522 15-oxoprostaglandin 13-oxidase activity Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+. MF
GO:0047528 2,3-dihydroxyindole 2,3-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2. MF
GO:0047529 2,3-dimethylmalate lyase activity Catalysis of the reaction: 2,3-dimethylmalate = propanoate + pyruvate. MF
GO:0043234 protein complex Any protein group composed of two or more subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. CC
GO:0043235 receptor complex Any protein group composed of two or more subunits, which may or may not be identical, which undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. CC
GO:0043236 laminin binding Interacting selectively with laminins, glycoproteins that are major constituents of the basement membrane of cells. MF
GO:0043237 laminin-1 binding Interacting selectively with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. MF
GO:0043230 extracellular organelle Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. CC
GO:0043231 intracellular membrane-bound organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. CC
GO:0043232 intracellular non-membrane-bound organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. CC
GO:0043233 organelle lumen The volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear membrane lumen. CC
GO:0043238 laminin-2 binding Interacting selectively with laminin-2, a glycoprotein trimer with the subunit composition alpha2, beta1, gamma 1. MF
GO:0043239 laminin-4 binding Interacting selectively with laminin-4, a glycoprotein trimer with the subunit composition alpha2, beta2, gamma 1. MF
GO:0016220 RAL GDP-dissociation stimulator activity NA MF
GO:0016223 beta-alanine-pyruvate transaminase activity Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine. MF
GO:0016222 procollagen-proline, 2-oxoglutarate-4-dioxygenase complex An enzyme complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. CC
GO:0016227 tRNA sulfurtransferase activity Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide. MF
GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. BP
GO:0045968 negative regulation of juvenile hormone biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. BP
GO:0045969 positive regulation of juvenile hormone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. BP
GO:0045966 positive regulation of ecdysteroid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids. BP
GO:0045967 negative regulation of growth rate Any process that reduces the rate of growth of all or part of an organism. BP
GO:0045964 positive regulation of dopamine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. BP
GO:0045965 negative regulation of ecdysteroid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids. BP
GO:0045962 positive regulation of development, heterochronic Any process that activates or increases the frequency, rate or extent of heterochronic development. BP
GO:0045963 negative regulation of dopamine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine. BP
GO:0045960 positive regulation of complement activation, classical pathway Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway. BP
GO:0045961 negative regulation of development, heterochronic Any process that stops, prevents or reduces the frequency, rate or extent of heterochronic development. BP
GO:0002026 cardiac inotropy Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. BP
GO:0030548 acetylcholine receptor regulator activity Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed. MF
GO:0030549 acetylcholine receptor activator activity Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased. MF
GO:0048825 cotyledon development The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. BP
GO:0030544 Hsp70 protein binding Interacting selectively with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. MF
GO:0030545 receptor regulator activity The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. MF
GO:0030546 receptor activator activity The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. MF
GO:0030547 receptor inhibitor activity The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. MF
GO:0030540 female genitalia development The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. BP
GO:0002024 diet induced thermogenesis The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system. BP
GO:0030542 plasmid partitioning (sensu Bacteria) Any process by which plasmids are segregated or distributed into daughter cells upon cell division. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0030543 2-micrometer plasmid partitioning The process by which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division. BP
GO:0002025 norepinephrine-epinephrine vasodilation during regulation of blood pressure A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change. BP
GO:0048820 hair follicle maturation A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. BP
GO:0048821 erythrocyte development The process aimed at the progression of an erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0048822 enucleate erythrocyte development The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0048823 nucleate erythrocyte development The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0008266 poly(U) binding Interacting selectively with a sequence of uracil residues in an RNA molecule. MF
GO:0008267 poly-glutamine tract binding Interacting selectively with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein. MF
GO:0008265 Mo-molybdopterin cofactor sulfurase activity NA MF
GO:0008262 importin-alpha export receptor activity NA MF
GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. MF
GO:0008260 3-oxoacid CoA-transferase activity Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA. MF
GO:0008261 allatostatin receptor activity Combining with allatostatin to initiate a change in cell activity. MF
GO:0008268 receptor signaling protein tyrosine kinase signaling protein activity NA MF
GO:0008269 JAK pathway signal transduction adaptor activity NA MF
GO:0032331 negative regulation of chondrocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte differentiation. BP
GO:0032330 regulation of chondrocyte differentiation Any process that modulates the frequency, rate or extent of chondrocyte differentiation. BP
GO:0032333 activin secretion The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone. BP
GO:0032332 positive regulation of chondrocyte differentiation Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. BP
GO:0032335 regulation of activin secretion Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell or group of cells. BP
GO:0032334 inhibin secretion The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone. BP
GO:0032337 positive regulation of activin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell or group of cells. BP
GO:0032336 negative regulation of activin secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of activin from a cell or group of cells. BP
GO:0032339 negative regulation of inhibin secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells. BP
GO:0032338 regulation of inhibin secretion Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells. BP
GO:0009664 cell wall organization and biogenesis (sensu Magnoliophyta) The assembly and arrangement of the cell wall; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0019901 protein kinase binding Interacting selectively with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. MF
GO:0019900 kinase binding Interacting selectively with a kinase, any enzyme that catalyzes the transfer of a phosphate group. MF
GO:0019903 protein phosphatase binding Interacting selectively with any protein phosphatase. MF
GO:0019902 phosphatase binding Interacting selectively with any phosphatase. MF
GO:0019905 syntaxin binding Interacting selectively with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. MF
GO:0019904 protein domain specific binding Interacting selectively with a specific domain of a protein. MF
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex NA CC
GO:0019909 [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase. MF
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the nucleus. CC
GO:0002505 antigen processing and presentation of polysaccharide antigen via MHC class II The process by which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex. BP
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II The process by which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. BP
GO:0002507 tolerance induction A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. BP
GO:0002506 polysaccharide assembly with MHC class II protein complex The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex. BP
GO:0002501 peptide antigen assembly with MHC protein complex The binding of a peptide to the antigen binding groove of an MHC protein complex. BP
GO:0002500 proteolysis within lysosome associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation. BP
GO:0002503 peptide antigen assembly with MHC class II protein complex The binding of a peptide to the antigen binding groove of an MHC class II protein complex. BP
GO:0002502 peptide antigen assembly with MHC class I protein complex The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules. BP
GO:0002509 central tolerance induction to self antigen Tolerance induction in the central lymphoid organs directed at self antigens. BP
GO:0002508 central tolerance induction Tolerance induction in the central lymphoid organs: the thymus and bone marrow. BP
GO:0009666 plastid outer membrane organization and biogenesis The assembly and arrangement of the outer membrane of a plastid. BP
GO:0009663 plasmodesma organization and biogenesis The assembly and arrangement of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. BP
GO:0042273 ribosomal large subunit biogenesis and assembly The formation of the constituents of the large ribosomal subunit, their assembly, and their transport to the sites of protein synthesis. BP
GO:0042272 nuclear RNA export factor complex A complex of NXF1 and NXF2 required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. CC
GO:0042271 susceptibility to natural killer cell mediated cytotoxicity The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity. BP
GO:0042270 protection from natural killer cell mediated cytotoxicity The process of protecting a cell from natural killer cell mediated cytotoxicity. BP
GO:0042277 peptide binding Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds. MF
GO:0042276 error-prone postreplication DNA repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication, without removing the replication-blocking lesions, and with an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. BP
GO:0042275 error-free postreplication DNA repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA without removing the replication-blocking lesions and without increasing the endogenous mutation rate. BP
GO:0042274 ribosomal small subunit biogenesis and assembly The formation of the constituents of the small ribosomal subunit, their assembly, and their transport to the sites of protein synthesis. BP
GO:0042279 nitrite reductase (cytochrome, ammonia-forming) activity Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = NO2(-) (nitrite) + 6 ferrocytochrome c + 7 H+. MF
GO:0042278 purine nucleoside metabolic process The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0006501 C-terminal protein lipidation The covalent or non-covalent attachment of a lipid moiety to the carboxy terminus of a protein. BP
GO:0006500 N-terminal protein palmitoylation The covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein. BP
GO:0006505 GPI anchor metabolic process The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate moiety, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. BP
GO:0003756 protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. MF
GO:0006507 GPI anchor release NA BP
GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. BP
GO:0006509 membrane protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). BP
GO:0006508 proteolysis The hydrolysis of a peptide bond or bonds within a protein. BP
GO:0043589 skin morphogenesis The process by which the anatomical structures of the skin are generated and organized. Morphogenesis pertains to the creation of form. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. BP
GO:0000213 tRNA-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. MF
GO:0000212 meiotic spindle organization and biogenesis The cell cycle process whereby the microtubule spindle is formed and maintained during a meiotic cell cycle. BP
GO:0000210 NAD+ diphosphatase activity Catalysis of the reaction: NAD+ + H2O = AMP + NMN. MF
GO:0000217 DNA secondary structure binding Interacting selectively with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. MF
GO:0000216 M/G1 transition of mitotic cell cycle Progression from M phase to G1 phase of the mitotic cell cycle. BP
GO:0000215 tRNA 2'-phosphotransferase activity Catalysis of the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. MF
GO:0000214 tRNA-intron endonuclease complex A complex that catalyses the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. CC
GO:0004909 interleukin-1, Type I, activating receptor activity NA MF
GO:0004908 interleukin-1 receptor activity Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. MF
GO:0004903 growth hormone receptor activity Combining with growth hormone to initiate a change in cell activity. MF
GO:0004902 granulocyte colony-stimulating factor receptor activity Combining with granulocyte colony-stimulating factor to initiate a change in cell activity. MF
GO:0004901 granulocyte macrophage colony-stimulating factor receptor activity Combining with granulocyte macrophage colony-stimulating factor to initiate a change in cell activity. MF
GO:0004900 erythropoietin receptor activity Combining with erythropoietin to initiate a change in cell activity. MF
GO:0004907 interleukin receptor activity Combining with an interleukin to initiate a change in cell activity. MF
GO:0004906 interferon-gamma receptor activity Combining with interferon-gamma to initiate a change in cell activity. MF
GO:0004905 interferon-alpha/beta receptor activity NA MF
GO:0004904 interferon receptor activity Combining with an interferon to initiate a change in cell activity. MF
GO:0051174 regulation of phosphorus metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. BP
GO:0051175 negative regulation of sulfur metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. BP
GO:0051176 positive regulation of sulfur metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. BP
GO:0051177 meiotic sister chromatid cohesion The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis. BP
GO:0051170 nuclear import The directed movement of substances into the nucleus. BP
GO:0051171 regulation of nitrogen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. BP
GO:0051172 negative regulation of nitrogen metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. BP
GO:0051173 positive regulation of nitrogen metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. BP
GO:0051178 meiotic chromosome decondensation The cell cycle process whereby chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells. BP
GO:0051179 localization The processes by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location. BP
GO:0010054 trichoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair. BP
GO:0010055 atrichoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair. BP
GO:0018269 GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0010057 trichoblast fate specification The process involved in the specification of a trichoblast. BP
GO:0010050 vegetative phase change The processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development. BP
GO:0010051 vascular tissue pattern formation (sensu Tracheophyta) The regionalization process that gives rise to the patterning of the conducting tissues, as in, but not restricted to, the vascular plants (Tracheophyta, ncbi_taxonomy_id:58023). BP
GO:0010052 guard cell differentiation The process whereby a relatively unspecialized epidermal cell acquires the specialized features of a guard cell. BP
GO:0010053 root epidermal cell differentiation The process whereby a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast. BP
GO:0018263 isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine. BP
GO:0018262 isopeptide cross-linking The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon. BP
GO:0018261 peptidyl-lysine guanylylation The posttranslational guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine. BP
GO:0018260 protein amino acid guanylylation The addition of phospho-guanosine to a protein amino acid. BP
GO:0018267 GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine The formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0018266 GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine The formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0018265 GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine The formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0018264 isopeptide cross-linking via N-(L-isoaspartyl)-glycine The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine. BP
GO:0005368 taurine transporter activity Enables the directed movement of taurine into, out of, within or between cells. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. MF
GO:0005369 taurine:sodium symporter activity Catalysis of the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). MF
GO:0005360 insulin-responsive hydrogen:glucose transporter activity NA MF
GO:0005361 transepithelial hydrogen:glucose transporter activity NA MF
GO:0005362 low-affinity glucose:sodium symporter activity Catalysis of the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). MF
GO:0005363 maltose transporter activity Enables the directed movement of maltose into, out of, within or between cells. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. MF
GO:0005364 maltose:hydrogen symporter activity Catalysis of the reaction: maltose(out) + H+(out) = maltose(in) + H+(in). MF
GO:0005365 myo-inositol transporter activity Enables the directed movement of myo-inositol into, out of, within or between cells. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. MF
GO:0005366 myo-inositol:hydrogen symporter activity Catalysis of the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in). MF
GO:0005367 myo-inositol:sodium symporter activity Catalysis of the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in). MF
GO:0004019 adenylosuccinate synthase activity Catalysis of the reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP. MF
GO:0004018 adenylosuccinate lyase activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. MF
GO:0051289 protein homotetramerization The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. BP
GO:0051286 cell tip The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth may occur. CC
GO:0051287 NAD binding Interacting selectively with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. MF
GO:0004013 adenosylhomocysteinase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. MF
GO:0004012 phospholipid-translocating ATPase activity Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP. MF
GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity Catalysis of the reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate. MF
GO:0004014 adenosylmethionine decarboxylase activity Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2. MF
GO:0004017 adenylate kinase activity Catalysis of the reaction: ATP + AMP = 2 ADP. MF
GO:0004016 adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. MF
GO:0007292 female gamete generation The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. BP
GO:0007293 egg chamber formation (sensu Insecta) Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007290 spermatid nuclear elongation The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation. BP
GO:0007291 sperm individualization The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane. BP
GO:0007296 vitellogenesis The production of yolk. Yolk is a mixture of materials used for embryonic nutrition. BP
GO:0007297 follicle cell migration (sensu Insecta) The directed movement of follicle cells that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007294 oocyte fate determination (sensu Insecta) Process by which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007295 egg chamber growth (sensu Insecta) Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007298 border follicle cell migration (sensu Insecta) The directed movement of the border cells through the nurse cells to reach the oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0007299 follicle cell adhesion (sensu Insecta) The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0001621 platelet ADP receptor activity NA MF
GO:0001623 Mas proto-oncogene receptor activity NA MF
GO:0001622 super conserved receptor expressed in brain receptor activity NA MF
GO:0001625 Epstein-Barr Virus-induced receptor activity NA MF
GO:0001624 RDC1 receptor activity NA MF
GO:0001627 leucine-rich G-protein receptor-like receptor activity NA MF
GO:0001626 nociceptin/orphanin-FQ receptor activity NA MF
GO:0018195 peptidyl-arginine modification The modification of peptidyl-arginine. BP
GO:0018194 peptidyl-alanine modification The modification of peptidyl-alanine. BP
GO:0018197 peptidyl-aspartic acid modification The modification of peptidyl-aspartic acid. BP
GO:0018196 peptidyl-asparagine modification The modification of peptidyl-asparagine. BP
GO:0015643 toxin binding Interacting selectively with a toxin, a poisonous substance that causes damage to biological systems. Toxins are differentiated from simple chemical poisons and vegetable alkaloids by their high molecular weight and antigenicity (they elicit an antibody response). MF
GO:0018190 protein amino acid octanoylation The modification of a protein amino acid by formation of an ester or amide with octanoic acid. BP
GO:0018193 peptidyl-amino acid modification The alteration of an amino acid residue in a peptide. BP
GO:0018192 enzyme active site formation via L-cysteine persulfide The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide. A persulfurated cysteine promotes active site reactivity in Azotobacter vinelandii Rhodanese. BP
GO:0001999 renal response to blood flow during renin-angiotensin regulation of blood pressure The physiological response of the kidneys to a decrease in blood flow. BP
GO:0001998 angiotensin mediated vasoconstriction during regulation of blood pressure The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream. BP
GO:0001993 norepinephrine-epinephrine regulation of blood pressure The process by which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system. BP
GO:0001992 regulation of blood pressure by vasopressin The process by which the secretion of vasopressin into the bloodstream modulates the force with which blood passes through the circulatory system. BP
GO:0001991 regulation of blood pressure by circulatory renin-angiotensin The process by which the secretion of angiotensin II into the bloodstream modulates the force with which blood passes through the circulatory system. BP
GO:0001990 regulation of blood pressure by hormones The process by which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. BP
GO:0001997 increased strength of heart contraction by epinephrine-norepinephrine Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream. BP
GO:0001996 positive regulation of heart contraction rate by epinephrine-norepinephrine The process by which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction. BP
GO:0001995 norepinephrine-epinephrine catabolic process in blood stream The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream. BP
GO:0001994 norepinephrine-epinephrine vasoconstriction during regulation of blood pressure A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure. BP
GO:0052483 negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction Any process by which an organism stops or prevents itself undergoing phagocytosis into a cell in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052482 cell wall thickening during defense response A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism. BP
GO:0052489 negative regulation by host of symbiont programmed cell death Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0021847 neuroblast division in the ventricular zone The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially. BP
GO:0021846 cell proliferation in the forebrain The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. BP
GO:0021845 neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner. BP
GO:0021844 interneuron sorting involved in substrate-independent cerebral cortex tangential migration The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures. BP
GO:0021843 substrate-independent telencephalic tangential interneuron migration The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. BP
GO:0021842 chemorepulsion involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex. BP
GO:0021841 chemoattraction involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex. BP
GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex. BP
GO:0021849 neuroblast division in the subventricular zone The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially. BP
GO:0021848 neuroblast division in the subpallium The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially. BP
GO:0016049 cell growth The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. BP
GO:0016048 detection of temperature stimulus The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. BP
GO:0016045 detection of bacterium The series of events in which a stimulus from a bacterium is received and converted into a molecular signal. BP
GO:0016044 membrane organization and biogenesis The assembly and arrangement of membranes inside and surrounding the cell. BP
GO:0016047 detection of parasitic fungus The series of events in which a stimulus from a parasitic fungus (a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection) is received and converted into a molecular signal. BP
GO:0016046 detection of fungus The series of events in which a stimulus from a fungus is received and converted into a molecular signal. BP
GO:0016041 glutamate synthase (ferredoxin) activity Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin. MF
GO:0016040 glutamate synthase (NADH) activity Catalysis of the reaction: 2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+. MF
GO:0016043 cell organization and biogenesis The processes involved in the assembly and arrangement of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. BP
GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. BP
GO:0048899 anterior lateral line development The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear. BP
GO:0048898 anterior lateral line system development The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. BP
GO:0008618 7-methylguanosine metabolic process The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. BP
GO:0008617 guanosine metabolic process The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution. BP
GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. CC
GO:0043625 delta DNA polymerase complex A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair. CC
GO:0008614 pyridoxine metabolic process The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. BP
GO:0008613 diuretic hormone activity NA MF
GO:0043622 cortical microtubule organization and biogenesis The assembly and arrangement of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell. BP
GO:0048891 lateral line ganglion neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron. BP
GO:0043621 protein self-association Interacting selectively with a domain within the same polypeptide. MF
GO:0005080 protein kinase C binding Interacting selectively with protein kinase C. MF
GO:0043620 regulation of transcription in response to stress Modulation of the frequency, rate or extent of transcription as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). BP
GO:0048893 afferent axon development in a lateral line nerve The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve. BP
GO:0048892 lateral line nerve development The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. BP
GO:0005085 guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0048894 efferent axon development in a lateral line nerve The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve. BP
GO:0015804 neutral amino acid transport The directed movement of neutral amino acids, amino acids with no net charge, into, out of, within or between cells. BP
GO:0015805 S-adenosylmethionine transport The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of, within or between cells. BP
GO:0015806 S-methylmethionine transport The directed movement of S-methylmethionine into, out of, within or between cells. BP
GO:0015807 L-amino acid transport The directed movement of levorotatory isomer amino acids into, out of, within or between cells. BP
GO:0015800 acidic amino acid transport The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells. BP
GO:0005087 Ran guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0015802 basic amino acid transport The directed movement of basic amino acids, amino acids with a pH above 7, into, out of, within or between cells. BP
GO:0015803 branched-chain aliphatic amino acid transport The directed movement of branched-chain aliphatic amino acids, amino acids with branched carbon skeleton without rings, into, out of, within or between cells. BP
GO:0048896 glial cell migration in a lateral line nerve The movement of glial cells along the axons in a lateral line nerve. BP
GO:0015808 L-alanine transport The directed movement of L-alanine, the levorotatory isomer of 2-aminopropanoic acid, into, out of, within or between cells. BP
GO:0015809 arginine transport The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of, within or between cells. BP
GO:0051905 establishment of pigment granule localization The directed movement of a pigment granule to a specific location. BP
GO:0051904 pigment granule transport The directed movement of pigment granules into, out of, within or between cells. BP
GO:0051907 S-(hydroxymethyl)glutathione synthase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione = glutathione + formaldehyde. MF
GO:0051906 maintenance of pigment granule localization The processes by which a pigment granule is maintained in a location and prevented from moving elsewhere. BP
GO:0051901 positive regulation of mitochondrial depolarization Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. BP
GO:0051900 regulation of mitochondrial depolarization Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. BP
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. MF
GO:0051902 negative regulation of mitochondrial depolarization Any process that stops, prevents or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. BP
GO:0051909 acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O. MF
GO:0051908 double-stranded DNA specific 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. MF
GO:0009337 sulfite reductase complex (NADPH) A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyses the reduction of hydrogen sulfide to sulfide. CC
GO:0009336 sulfate adenylyltransferase complex (ATP) An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP. CC
GO:0009334 3-phenylpropionate dioxygenase complex Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol). CC
GO:0009333 cysteine synthase complex Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A. CC
GO:0009332 glutamate-tRNA ligase complex An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu). CC
GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. CC
GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity. CC
GO:0009339 glycolate oxidase complex An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN). CC
GO:0009338 exodeoxyribonuclease V complex An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. CC
GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)). MF
GO:0004076 biotin synthase activity Catalysis of the reaction: dethiobiotin + sulfur = biotin. MF
GO:0004075 biotin carboxylase activity Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. MF
GO:0004074 biliverdin reductase activity Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+. MF
GO:0004073 aspartate-semialdehyde dehydrogenase activity Catalysis of the reaction: L-aspartate-4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH + H+. MF
GO:0004072 aspartate kinase activity Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. MF
GO:0042972 licheninase activity Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds. MF
GO:0004070 aspartate carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. MF
GO:0008064 regulation of actin polymerization and/or depolymerization Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. BP
GO:0008065 establishment of blood-nerve barrier The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier. BP
GO:0008066 glutamate receptor activity Combining with glutamate to initiate a change in cell activity. MF
GO:0008067 metabotropic glutamate, GABA-B-like receptor activity A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor. MF
GO:0008060 ARF GTPase activator activity Increases the rate of GTP hydrolysis by the GTPase ARF. MF
GO:0008061 chitin binding Interacting selectively with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. MF
GO:0016869 intramolecular transferase activity, transferring amino groups Catalysis of the transfer of an amino group from one position to another within a single molecule. MF
GO:0016868 intramolecular transferase activity, phosphotransferases Catalysis of the transfer of a phosphate group from one position to another within a single molecule. MF
GO:0016867 intramolecular transferase activity, transferring acyl groups Catalysis of the transfer of an acyl group from one position to another within a single molecule. MF
GO:0016866 intramolecular transferase activity Catalysis of the transfer of a functional group from one position to another within a single molecule. MF
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds NA MF
GO:0008068 glutamate-gated chloride channel activity NA MF
GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups NA MF
GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses NA MF
GO:0016860 intramolecular oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. MF
GO:0014032 neural crest cell development The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. BP
GO:0014033 neural crest cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neural crest cell. BP
GO:0014030 mesenchymal cell fate commitment The process by which a cell becomes committed to become a mesenchymal cell. BP
GO:0014031 mesenchymal cell development The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. BP
GO:0014036 neural crest cell fate specification The process by which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0014037 Schwann cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. BP
GO:0014034 neural crest cell fate commitment The process by which a cell becomes committed to become a neural crest cell. BP
GO:0014035 neural crest cell fate determination The process by which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0014038 regulation of Schwann cell differentiation Any process that modulates the frequency, rate or extent of Schwann cell differentiation. BP
GO:0014039 negative regulation of Schwann cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell differentiation. BP
GO:0045315 positive regulation of eye photoreceptor development (sensu Endopterygota) Any process that activates or increases the frequency, rate or extent of photoreceptor development. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045314 regulation of eye photoreceptor development (sensu Endopterygota) Any process that modulates the frequency, rate or extent of photoreceptor development. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045317 equator specification The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves. BP
GO:0045316 negative regulation of eye photoreceptor development (sensu Endopterygota) Any process that stops, prevents or reduces the frequency, rate or extent of photoreceptor development. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045311 filamentous growth in response to pheromones The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus. BP
GO:0045313 rhabdomere membrane biogenesis The assembly and maintenance of the rhabdomere membrane. BP
GO:0045312 nor-spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. BP
GO:0015075 ion transporter activity Enables the directed movement of charged atoms or small charged molecules into, out of, within or between cells. MF
GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. BP
GO:0015077 monovalent inorganic cation transporter activity Enables the directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. MF
GO:0047224 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP. MF
GO:0015071 protein phosphatase type 2C activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. MF
GO:0047222 mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP. MF
GO:0047221 sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + UDP. MF
GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP. MF
GO:0015079 potassium ion transporter activity Enables the directed movement of potassium ions (K+) into, out of, within or between cells. MF
GO:0015078 hydrogen ion transporter activity Enables the directed movement of hydrogen ions into, out of, within or between cells. MF
GO:0047229 13-hydroxydocosanoate 13-beta-glucosyltransferase activity Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP. MF
GO:0047228 1,2-diacylglycerol 3-glucosyltransferase activity Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP. MF
GO:0046574 glycuronidase activity Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid. MF
GO:0046575 rhamnogalacturonan acetylesterase activity Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan. MF
GO:0046576 rhamnogalacturonase B activity Catalysis of the cleavage of (1,2)-alpha-L-Rhap-(1,4)-alpha-D-GalpA glycosidic linkage, generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue. MF
GO:0046577 long-chain-alcohol oxidase activity Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O. MF
GO:0046570 5-methylthioribulose-1-phosphate 4-dehydratase activity Catalysis of the reaction: methylthioribulose-1-phosphate = 2,3-diketo-5-methylthio-1-phosphopentane + H2O. MF
GO:0046571 aspartate-2-keto-4-methylthiobutyrate transaminase activity Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate. MF
GO:0046572 versicolorin B synthase activity Catalysis of the ring closure reaction: versiconal hemiacetal = versicolorin B + H2O. MF
GO:0046573 lactonohydrolase activity Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group. MF
GO:0046578 regulation of Ras protein signal transduction Any process that modulates the frequency, rate or extent of Ras protein signal transduction. BP
GO:0046579 positive regulation of Ras protein signal transduction Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. BP
GO:0035239 tube morphogenesis The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. BP
GO:0035238 vitamin A biosynthetic process The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids. BP
GO:0031564 transcription antitermination Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site. BP
GO:0035235 ionotropic glutamate receptor signaling pathway The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex. BP
GO:0035234 germ cell programmed cell death Programmed cell death of errant germ line cells that are outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. BP
GO:0035237 corazonin receptor activity Combining with the neuropeptide corazonin to initiate a change in cell activity. MF
GO:0035236 proctolin receptor activity Combining with the neuropeptide proctolin, to initiate a change in cell activity. MF
GO:0035231 cytoneme biogenesis Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell. BP
GO:0035230 cytoneme A long, thin and polarized actin-based extension that projects from a cell and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um. CC
GO:0035233 germ cell repulsion The directed movement of germ cells from their site of production to the gonad, through the repulsion of cells away from a tissue. BP
GO:0035232 germ cell attraction The directed movement of germ cells from their site of production to the gonad, through the attraction of cells towards their target. BP
GO:0047483 imidazoleacetate-phosphoribosyldiphosphate ligase activity Catalysis of the reaction: 5-phosphoribosyl diphosphate + imidazole-4-acetate + ATP = phosphate + pyrophosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + ADP. MF
GO:0047482 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine + ATP = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ADP. MF
GO:0047481 D-alanine-alanyl-poly(glycerolphosphate) ligase activity Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP. MF
GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. MF
GO:0047487 oligogalacturonide lyase activity Catalysis of the reaction: 4-(4-deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate = 25-dehydro-4-deoxy-D-glucuronate. MF
GO:0047486 chondroitin ABC lyase activity Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. MF
GO:0047485 protein N-terminus binding Interacting selectively with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. MF
GO:0047484 regulation of response to osmotic stress Any process that modulates the rate or extent of the response to osmotic stress. BP
GO:0047489 pectate disaccharide-lyase activity Catalysis of the eliminative cleavage of 4-(4-deoxy-a-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin. MF
GO:0047488 heparin lyase activity Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends. MF
GO:0016528 sarcoplasm The cytoplasm of a muscle fiber; includes the sarcoplasmic reticulum. CC
GO:0016529 sarcoplasmic reticulum A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle fiber; continuous over large portions of the cell and with the nuclear envelope; an endoplasmic reticulum specialized for the sequestration of calcium ions. CC
GO:0016520 growth hormone-releasing hormone receptor activity Combining with growth hormone-releasing hormone to initiate a change in cell activity. MF
GO:0016521 pituitary adenylate cyclase activating polypeptide activity NA MF
GO:0016527 brain-specific angiogenesis inhibitor activity NA MF
GO:0016524 latrotoxin receptor activity Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity. MF
GO:0016525 negative regulation of angiogenesis Any process that stops, prevents or reduces the frequency, rate or extent of angiogenesis. BP
GO:0031568 G1/S transition size control checkpoint A cell cycle checkpoint that blocks cell cycle progression from G1 to S phase until cells have reached a critical size. BP
GO:0045885 positive regulation of survival gene product activity Any process that activates or increases the frequency, rate or extent of survival gene product activity; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level. BP
GO:0045884 regulation of survival gene product activity Any process that modulates the frequency, rate or extent of survival gene product activity; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level. BP
GO:0045887 positive regulation of synaptic growth at neuromuscular junction Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction. BP
GO:0045886 negative regulation of synaptic growth at neuromuscular junction Any process that stops, prevents or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction. BP
GO:0045881 positive regulation of sporulation Any process that activates or increases the frequency, rate or extent of sporulation. BP
GO:0045880 positive regulation of smoothened signaling pathway Any process that activates or increases the frequency, rate or extent of smoothened signaling. BP
GO:0045883 positive regulation of sulfur utilization Any process that activates or increases the frequency, rate or extent of sulfur utilization. BP
GO:0045882 negative regulation of sulfur utilization Any process that stops, prevents or reduces the frequency, rate or extent of sulfur utilization. BP
GO:0043065 positive regulation of apoptosis Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. BP
GO:0043064 flagellum organization and biogenesis The assembly and arrangement of a flagellum, a long thin projection from a cell, used in movement. BP
GO:0043067 regulation of programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. BP
GO:0043066 negative regulation of apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis. BP
GO:0043061 meiotic metaphase II plate congression The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II. BP
GO:0043060 meiotic metaphase I plate congression The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I. BP
GO:0046688 response to copper ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. BP
GO:0043062 extracellular structure organization and biogenesis The assembly and arrangement of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. BP
GO:0046686 response to cadmium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. BP
GO:0046687 response to chromate A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus. BP
GO:0046684 response to pyrethroid A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage. BP
GO:0046685 response to arsenic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. BP
GO:0043069 negative regulation of programmed cell death Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. BP
GO:0043068 positive regulation of programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. BP
GO:0046680 response to DDT A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals. BP
GO:0046681 response to carbamate A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. BP
GO:0031266 TRAIL death-inducing signaling complex A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor. CC
GO:0031267 small GTPase binding Interacting selectively with a small monomeric GTPase. MF
GO:0031264 death-inducing signaling complex A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor. CC
GO:0031265 CD95 death-inducing signaling complex A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor. CC
GO:0031262 Ndc80 complex A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore. CC
GO:0031263 amine-transporting ATPase activity Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in). MF
GO:0031260 pseudopodium membrane The portion of the plasma membrane surrounding a pseudopodium. CC
GO:0031261 DNA replication preinitiation complex A multiprotein complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dbp11p, DNA polymerases, and others. CC
GO:0031268 pseudopodium organization and biogenesis The assembly and arrangement of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. BP
GO:0031269 pseudopodium formation The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. BP
GO:0048358 mucilage pectin biosynthetic process The chemical reactions and pathways resulting in the formation of the pectin component of mucilage. BP
GO:0048359 mucilage metabolic process during seed coat development The chemical reactions and pathways involving mucilage that occur during seed coat development; mucilage is normally synthesized during seed coat development. BP
GO:0048356 root epithelial mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. BP
GO:0048357 pedicel mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem. BP
GO:0048354 mucilage biosynthetic process during seed coat development The chemical reactions and pathways resulting in the formation of mucilage that occur during seed coat development; mucilage is normally synthesized during seed coat development. BP
GO:0048355 root cap mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth. BP
GO:0048352 paraxial mesoderm structural organization The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048353 primary endosperm nucleus Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac. CC
GO:0048350 positive regulation of paraxial mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification. BP
GO:0048351 negative regulation of paraxial mesodermal cell fate specification Any process that stops, prevents or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification. BP
GO:0009078 pyruvate family amino acid metabolic process The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine. BP
GO:0009079 pyruvate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine. BP
GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP. MF
GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. MF
GO:0050506 vomilenine glucosyltransferase activity Catalysis of the reaction: vomilenine + UDP-D-glucose = raucaffricine + UDP. MF
GO:0050507 indoxyl-UDPG glucosyltransferase activity Catalysis of the reaction: indoxyl + UDP-D-glucose = indican + UDP. MF
GO:0009076 histidine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the histidine family. BP
GO:0050505 hydroquinone glucosyltransferase activity Catalysis of the reaction: hydroquinone + UDP-D-glucose = hydroquinone-O-beta-D-glucopyranoside + UDP. MF
GO:0050502 cis-zeatin O-beta-D-glucosyltransferase activity Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + UDP. MF
GO:0050503 trehalose 6-phosphate phosphorylase activity Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate. MF
GO:0050500 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1,3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate. MF
GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). BP
GO:0019001 guanyl nucleotide binding Interacting selectively with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. MF
GO:0019002 GMP binding Interacting selectively with GMP, guanosine monophosphate. MF
GO:0019003 GDP binding Interacting selectively with GDP, guanosine 5'-diphosphate. MF
GO:0019005 SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). CC
GO:0019007 N-acetylneuraminic acid phosphate synthase activity NA MF
GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. CC
GO:0050105 L-gulonolactone oxidase activity Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2. MF
GO:0032106 positive regulation of response to extracellular stimulus Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. BP
GO:0032107 regulation of response to nutrient levels NA BP
GO:0032104 regulation of response to extracellular stimulus Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. BP
GO:0032105 negative regulation of response to extracellular stimulus Any process that stops, prevents or reduces the frequency, rate or extent of a response to an extracellular stimulus. BP
GO:0032102 negative regulation of response to external stimulus Any process that stops, prevents or reduces the frequency, rate or extent of a response to an external stimulus. BP
GO:0032103 positive regulation of response to external stimulus Any process that activates, maintains or increases the rate of a response to an external stimulus. BP
GO:0032100 positive regulation of appetite Any process that increases appetite. BP
GO:0032101 regulation of response to external stimulus Any process that modulates the frequency, rate or extent of a response to an external stimulus. BP
GO:0032108 negative regulation of response to nutrient levels NA BP
GO:0032109 positive regulation of response to nutrient levels NA BP
GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. CC
GO:0000809 cytoplasmic origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm. CC
GO:0000806 Y chromosome The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males. CC
GO:0000807 Z chromosome The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females. CC
GO:0000804 W chromosome The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females. CC
GO:0000805 X chromosome The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males. CC
GO:0000802 transverse filament A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them. CC
GO:0000803 sex chromosome A chromosome involved in sex determination. CC
GO:0000800 lateral element A proteinaceous core found between sister chromatids during meiotic prophase. CC
GO:0000801 central element A structural unit of the synaptonemal complex found between the lateral elements. CC
GO:0048861 leukemia inhibitory factor signaling pathway The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands. BP
GO:0005856 cytoskeleton Any of the various filamentous elements within the cytoplasm of eukaryotic cells that remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. CC
GO:0005854 nascent polypeptide-associated complex A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. CC
GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. CC
GO:0051474 glucosylglycerol transporter activity Enables the directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of, within or between cells. MF
GO:0005971 ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. CC
GO:0005970 serine-pyruvate aminotransferase, type 1 complex An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate. CC
GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. BP
GO:0051477 mannosylglycerate transporter activity Enables the directed movement of mannosylglycerate into, out of, within or between cells. MF
GO:0005977 glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. BP
GO:0005976 polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages. BP
GO:0005979 regulation of glycogen biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. BP
GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. BP
GO:0005851 eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. CC
GO:0048867 stem cell fate determination The process whereby a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0006776 vitamin A metabolic process The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene. BP
GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. BP
GO:0006775 fat-soluble vitamin metabolic process The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. BP
GO:0006772 thiamin metabolic process The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. BP
GO:0006771 riboflavin metabolic process The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). BP
GO:0006778 porphyrin metabolic process The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. BP
GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. BP
GO:0000396 U2-type spliceosome conformational change to release U4 and U1 Rearrangement of the pre-catalytic spliceosome containing U4 and U1 snRNPs to unpair U4 from U6 and release it from the spliceosomal complex along with U1. BP
GO:0000397 U12-type spliceosome conformational change to release U4atac and U11 Rearrangement of the pre-catalytic spliceosome containing U4atac and U11 snRNPs to unpair U4atac from U6atac and release it from the spliceosomal complex along with U11. BP
GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. BP
GO:0000395 nuclear mRNA 5'-splice site recognition Recognition of the intron 5'-splice site by components of the assembling spliceosome. BP
GO:0000392 U12-dependent spliceosome disassembly Disassembly of the U12-type spliceosome with the ATP-dependent release of the RNA composed of the joined exons and the lariat intron RNA. BP
GO:0007243 protein kinase cascade A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. BP
GO:0000390 spliceosome disassembly Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. BP
GO:0000391 U2-dependent spliceosome disassembly Disassembly of the U2-type spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. The other product is the excised sequence. In cis splicing, this forms a lariat structure. BP
GO:0000398 nuclear mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. BP
GO:0000399 bud neck septin structure Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle. CC
GO:0000028 ribosomal small subunit assembly and maintenance The maintenance and assembly of the small ribosomal subunit from its constituent parts. BP
GO:0000022 mitotic spindle elongation Lengthening of the distance between poles of the mitotic spindle. BP
GO:0000023 maltose metabolic process The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. BP
GO:0000024 maltose biosynthetic process The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). BP
GO:0000025 maltose catabolic process The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). BP
GO:0000026 alpha-1,2-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage. MF
GO:0000027 ribosomal large subunit assembly and maintenance The maintenance and assembly of the large ribosomal subunit from its constituent parts. BP
GO:0004738 pyruvate dehydrogenase activity Catalysis of the oxidative decarboxylation of pyruvate. MF
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. MF
GO:0004730 pseudouridylate synthase activity Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O. MF
GO:0004731 purine-nucleoside phosphorylase activity Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. MF
GO:0004732 pyridoxal oxidase activity Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + H2O2. MF
GO:0004733 pyridoxamine-phosphate oxidase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2. MF
GO:0004734 pyrimidodiazepine synthase activity Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione. MF
GO:0004735 pyrroline-5-carboxylate reductase activity Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. MF
GO:0004736 pyruvate carboxylase activity Catalysis of the reaction: ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate. MF
GO:0004737 pyruvate decarboxylase activity Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2. MF
GO:0003813 classical-complement-pathway C3/C5 convertase activity Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b. MF
GO:0003815 complement component C1r activity Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42). MF
GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. CC
GO:0007559 histolysis The breakdown of tissues; usually, if not always, accompanied by cell death. BP
GO:0051324 prophase Progression through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. BP
GO:0015279 store-operated calcium channel activity NA MF
GO:0015278 calcium-release channel activity NA MF
GO:0051321 meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell. BP
GO:0051320 S phase Progression through S phase, the part of the cell cycle during which DNA synthesis takes place. BP
GO:0051323 metaphase Progression through metaphase, the second stage of chromosome segregation in the cell cycle. Canonically, chromosomes become aligned on the equatorial plate of the cell. BP
GO:0051322 anaphase Progression through anaphase, the third stage of chromosome segregation in the cell cycle. Canonically, sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle. BP
GO:0015273 G-protein enhanced inward rectifier potassium channel activity NA MF
GO:0015272 ATP-activated inward rectifier potassium channel activity NA MF
GO:0015271 outward rectifier potassium channel activity NA MF
GO:0007552 metamorphosis A change of shape or structure of the whole organism from one developmental stage to another, particularly the rapid post embryonic structural transformation from larval to adult form. BP
GO:0007555 regulation of ecdysteroid secretion Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell or group of cells. BP
GO:0051328 interphase of meiotic cell cycle Progression through interphase, the stage of cell cycle between successive rounds of meiosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs. BP
GO:0015275 stretch-activated, cation-selective, calcium channel activity NA MF
GO:0015274 organellar voltage-gated chloride channel activity NA MF
GO:0018019 N-terminal peptidyl-glutamine methylation The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative. BP
GO:0018010 glycoprotein N-palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein. MF
GO:0018011 N-terminal peptidyl-alanine methylation The methylation of the N-terminal alanine of proteins. BP
GO:0018012 N-terminal peptidyl-alanine tri-methylation The tri-methylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine. BP
GO:0018013 N-terminal peptidyl-glycine methylation The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine. BP
GO:0018014 N-terminal peptidyl-methionine methylation The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine. BP
GO:0018015 N-terminal peptidyl-phenylalanine methylation The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine. BP
GO:0018016 N-terminal peptidyl-proline di-methylation The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline. BP
GO:0019769 low affinity IgE receptor activity Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity. MF
GO:0019768 high affinity IgE receptor activity Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity. MF
GO:0019761 glucosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. BP
GO:0019760 glucosinolate metabolic process The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans. BP
GO:0019763 immunoglobulin receptor activity Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity. MF
GO:0019762 glucosinolate catabolic process The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. BP
GO:0019767 IgE receptor activity Combining with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity. MF
GO:0019766 IgA receptor activity Combining with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity. MF
GO:0031043 O-glycan processing, core 7 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-1->6-GalNAc. BP
GO:0001816 cytokine production The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0001817 regulation of cytokine production Any process that modulates the frequency, rate, or extent of production of a cytokine. BP
GO:0001814 negative regulation of antibody-dependent cellular cytotoxicity Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity. BP
GO:0001815 positive regulation of antibody-dependent cellular cytotoxicity Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity. BP
GO:0001812 positive regulation of type I hypersensitivity Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response. BP
GO:0001813 regulation of antibody-dependent cellular cytotoxicity Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity. BP
GO:0001810 regulation of type I hypersensitivity Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response. BP
GO:0001811 negative regulation of type I hypersensitivity Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response. BP
GO:0001818 negative regulation of cytokine production Any process that stops, prevents, or reduces the rate of production of a cytokine. BP
GO:0001819 positive regulation of cytokine production Any process that activates or increases the frequency, rate or extent of production of a cytokine. BP
GO:0030337 DNA polymerase processivity factor activity An accessory subunit of DNA polymerase that acts to increase the processivity of polymerization. MF
GO:0030336 negative regulation of cell migration Any process that stops, prevents or reduces the frequency, rate or extent of cell migration. BP
GO:0030335 positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration. BP
GO:0030334 regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration. BP
GO:0030332 cyclin binding Interacting selectively with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. MF
GO:0030331 estrogen receptor binding Interacting selectively with an estrogen receptor. MF
GO:0030330 DNA damage response, signal transduction by p53 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. BP
GO:0031047 RNA-mediated gene silencing Any process by which RNA molecules inactivate expression of target genes. BP
GO:0030339 fatty-acyl-ethyl-ester synthase activity Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol. MF
GO:0030338 CMP-N-acetylneuraminate monooxygenase activity Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O. MF
GO:0017103 UTP:galactose-1-phosphate uridylyltransferase activity Catalysis of the reaction: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose. MF
GO:0017102 methionyl glutamyl tRNA synthetase complex A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers. CC
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. CC
GO:0017100 aminoacyl-tRNA synthetase auxiliary protein activity NA MF
GO:0017107 anion exchanger adaptor activity NA MF
GO:0017106 activin inhibitor activity Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone. MF
GO:0031045 dense core granule Electron-dense organelle found in ciliates, with a granular internal matrix; contains proteins destined to be secreted. CC
GO:0017109 glutamate-cysteine ligase complex An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine. CC
GO:0017108 5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. MF
GO:0002644 negative regulation of tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction. BP
GO:0031064 negative regulation of histone deacetylation Any process that stops, prevents or reduces the frequency, rate or extent of the removal of acetyl groups from histones. BP
GO:0031065 positive regulation of histone deacetylation Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. BP
GO:0031066 regulation of histone deacetylation at centromere Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA. BP
GO:0031067 negative regulation of histone deacetylation at centromere Any process that stops, prevents or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA. BP
GO:0031060 regulation of histone methylation Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. BP
GO:0031061 negative regulation of histone methylation Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. BP
GO:0031062 positive regulation of histone methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. BP
GO:0031063 regulation of histone deacetylation Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. BP
GO:0031068 positive regulation of histone deacetylation at centromere Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA. BP
GO:0031069 hair follicle morphogenesis The process by which the anatomical structures of the hair follicle are generated and organized. BP
GO:0035024 negative regulation of Rho protein signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of Rho protein signal transduction. BP
GO:0035025 positive regulation of Rho protein signal transduction Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. BP
GO:0035026 leading edge cell differentiation The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet. BP
GO:0035027 leading edge cell fate commitment The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet. BP
GO:0035022 positive regulation of Rac protein signal transduction Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction. BP
GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. BP
GO:0009272 cell wall biosynthetic process (sensu Fungi) The chemical reactions and pathways resulting in the formation of the cell wall. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0009273 cell wall biosynthetic process (sensu Bacteria) The chemical reactions and pathways resulting in the formation of the cell wall. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0009270 response to humidity A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere. BP
GO:0009271 phage shock A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. BP
GO:0009276 cell wall (sensu ProteoBacteria) The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (approximately 2 nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. As in but not restricted to the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0009277 cell wall (sensu Fungi) A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis. Major components are glycoproteins and peptidoglycans including mannoproteins, glucans and sometimes chitin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0009274 cell wall (sensu Bacteria) A protective structure outside the cytoplasmic membrane composed of peptidoglycan, a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids; also called murein. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009275 cell wall (sensu Firmicutes) A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (approximately 40 nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. As in but not restricted to the Gram-positive bacteria (Firmicutes, ncbi_taxonomy_id:1239). CC
GO:0009279 outer membrane (sensu ProteoBacteria) A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0010143 cutin biosynthetic process The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants. BP
GO:0017081 chloride channel regulator activity NA MF
GO:0022619 generative cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte. BP
GO:0022618 protein-RNA complex assembly The aggregation and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. BP
GO:0022613 ribonucleoprotein complex biogenesis and assembly The cellular process by which a complex containing RNA and proteins, is synthesized, aggregates, and bonds together. BP
GO:0022612 gland morphogenesis The process by which the anatomical structures of a gland are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0022611 dormancy process The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity. BP
GO:0022610 biological adhesion The attachment of a cell or organism to a substrate or other organism. BP
GO:0022617 extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix. BP
GO:0022616 DNA strand elongation The DNA metabolic process by which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. BP
GO:0022615 protein to membrane docking The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere. BP
GO:0022614 membrane to membrane docking The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere. BP
GO:0032744 positive regulation of interleukin-20 production Any process that activates or increases the frequency, rate, or extent of interleukin-20 production. BP
GO:0032745 positive regulation of interleukin-21 production Any process that activates or increases the frequency, rate, or extent of interleukin-21 production. BP
GO:0032746 positive regulation of interleukin-22 production Any process that activates or increases the frequency, rate, or extent of interleukin-22 production. BP
GO:0032747 positive regulation of interleukin-23 production Any process that activates or increases the frequency, rate, or extent of interleukin-23 production. BP
GO:0032740 positive regulation of interleukin-17 production Any process that activates or increases the frequency, rate, or extent of interleukin-17 production. BP
GO:0032741 positive regulation of interleukin-18 production Any process that activates or increases the frequency, rate, or extent of interleukin-18 production. BP
GO:0032742 positive regulation of interleukin-19 production Any process that activates or increases the frequency, rate, or extent of interleukin-19 production. BP
GO:0032743 positive regulation of interleukin-2 production Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. BP
GO:0032748 positive regulation of interleukin-24 production Any process that activates or increases the frequency, rate, or extent of interleukin-24 production. BP
GO:0032749 positive regulation of interleukin-25 production Any process that activates or increases the frequency, rate, or extent of interleukin-25 production. BP
GO:0010144 pyridoxal phosphate biosynthetic process from pyridoxamine The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine. BP
GO:0045298 tubulin complex A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly. CC
GO:0043604 amide biosynthetic process The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. BP
GO:0043607 formamide biosynthetic process The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid. BP
GO:0008636 caspase activation via phosphorylation Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group. BP
GO:0008631 induction of apoptosis by oxidative stress The activation, by oxidative stress, of any of the steps required for cell death by apoptosis. BP
GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death). BP
GO:0043603 amide metabolic process The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. BP
GO:0043602 nitrate catabolic process The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid. BP
GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose. MF
GO:0045291 nuclear mRNA trans splicing, splice leader addition The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body. BP
GO:0045292 nuclear mRNA cis splicing, via U2-type spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via U2-type spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. BP
GO:0045293 mRNA editing complex A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes. CC
GO:0043609 regulation of carbon utilization Any process that modulates the frequency, rate, or extent of carbon utilization. BP
GO:0043608 formamide catabolic process The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid. BP
GO:0045296 cadherin binding Interacting selectively with cadherin, a type I membrane protein involved in cell adhesion. MF
GO:0045297 post-mating behavior The specific actions or reactions of an organism following mating. BP
GO:0017088 X-Pro dipeptidyl-peptidase activity Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile. MF
GO:0005100 Rho GTPase activator activity Increases the rate of GTP hydrolysis by a GTPase of the Rho family. MF
GO:0005101 Sar GTPase activator activity Increases the rate of GTP hydrolysis by the GTPase Sar. MF
GO:0046725 negative regulation of viral protein levels in host cell Any process that reduces the levels of viral proteins in a cell. BP
GO:0046724 oxalic acid secretion The regulated release of oxalic acid, ethanedioic acid, by a cell or group of cells. BP
GO:0046727 capsomere Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses. CC
GO:0046726 positive regulation of viral protein levels in host cell Any process that increases the levels of viral proteins in a cell. BP
GO:0046721 formic acid secretion The regulated release of formic acid, HCOOH, by a cell or group of cells. BP
GO:0046720 citric acid secretion The regulated release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or group of cells. BP
GO:0046723 malic acid secretion The regulated release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or group of cells. BP
GO:0046722 lactic acid secretion The regulated release of lactic acid, 2-hydroxypropanoic acid, by a cell or group of cells. BP
GO:0002673 regulation of acute inflammatory response Any process that modulates the frequency, rate, or extent of an acute inflammatory response. BP
GO:0002672 positive regulation of B cell anergy Any process that activates or increases the frequency, rate, or extent of B cell anergy. BP
GO:0002671 negative regulation of B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy. BP
GO:0002670 regulation of B cell anergy Any process that modulates the frequency, rate, or extent of B cell anergy. BP
GO:0002677 negative regulation of chronic inflammatory response Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response. BP
GO:0046728 viral capsid (sensu Retroviridae) The protein coat that surrounds the viral nucleocapsid, which in turn encapsulates the infective nucleic acid in retrovirus particles; the structure is complex, and specific structures and functions are associated with different elements of the capsid. As in, but not restricted to, the Retroviridae (Retroviridae, ncbi_taxonomy_id:11632). CC
GO:0002675 positive regulation of acute inflammatory response Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. BP
GO:0002674 negative regulation of acute inflammatory response Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. BP
GO:0047043 3-alpha-hydroxycholanate dehydrogenase activity Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-cholanate = NADH + H+ + 3-oxo-5-beta-cholanate. MF
GO:0047042 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. MF
GO:0005102 receptor binding Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. MF
GO:0042035 regulation of cytokine biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. BP
GO:0042034 peptidyl-lysine esterification The chemical reactions and pathways resulting in the formation of peptidyl-L-lysine methyl ester. BP
GO:0042037 peptidyl-histidine methylation, to form pros-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). BP
GO:0042036 negative regulation of cytokine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. BP
GO:0035002 tracheal liquid clearance The clearance of liquid from the epithelial tubes of the insect tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system. BP
GO:0035003 subapical complex The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells. CC
GO:0035001 dorsal trunk growth Growth of epithelial tubes that originate from tracheal pits and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system. BP
GO:0030078 light-harvesting complex, core complex Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria. CC
GO:0030079 light-harvesting complex, peripheral complex Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center. CC
GO:0035004 phosphoinositide 3-kinase activity Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]. MF
GO:0035005 phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate. MF
GO:0030075 thylakoid (sensu CyanoBacteria) A thylakoid; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117). CC
GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. CC
GO:0030077 light-harvesting complex (sensu ProteoBacteria) A light-harvesting complex; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0030070 insulin processing The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges. BP
GO:0030071 regulation of mitotic metaphase/anaphase transition Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle. BP
GO:0030072 peptide hormone secretion The regulated release of a peptide hormone from secretory granules. BP
GO:0030073 insulin secretion The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. BP
GO:0005104 fibroblast growth factor receptor binding Interacting selectively with the fibroblast growth factor receptor (FGFR). MF
GO:0005105 type 1 fibroblast growth factor receptor binding Interacting selectively with the type 1 fibroblast growth factor receptor (FGFR1). MF
GO:0048495 Roundabout binding Interacting selectively with the Roundabout (ROBO) receptor, a transmembrane receptor. MF
GO:0048494 ribulose bisphosphate carboxylase complex (sensu Proteobacteria, Chloroflexaceae and Chlorobiaceae) A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. As in, but not restricted to: the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224), the filamentous anoxygenic phototrophic bacteria (Chloroflexaceae, ncbi_taxonomy_id:1106), and the green sulfur bacteria (Chlorobiaceae, ncbi_taxonomy_id:191412). CC
GO:0048497 maintenance of floral organ identity The process by which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0048496 maintenance of organ identity The process by which the identity of an organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0048491 retrograde synaptic vesicle transport The directed movement of substances in synaptic membrane-bound vesicles within the neuron, along the cytoskeleton, toward the neuronal cell body. BP
GO:0048490 anterograde synaptic vesicle transport The directed movement of substances in synaptic membrane-bound vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body. BP
GO:0048493 ribulose bisphosphate carboxylase complex (sensu CyanoBacteria) A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. As in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117). CC
GO:0048492 ribulose bisphosphate carboxylase complex A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. CC
GO:0048499 synaptic vesicle membrane organization and biogenesis The assembly and arrangement of the membrane surrounding a synaptic vesicle. BP
GO:0048498 establishment of petal orientation The process that determines the orientation of petals with reference to the central axis. BP
GO:0004536 deoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. MF
GO:0004537 caspase-activated deoxyribonuclease activity NA MF
GO:0004534 5'-3' exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. MF
GO:0004535 poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. MF
GO:0004532 exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. MF
GO:0004533 exoribonuclease H activity Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions. MF
GO:0004530 deoxyribonuclease I activity Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. MF
GO:0004531 deoxyribonuclease II activity Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products. MF
GO:0002000 detection of renal blood flow The process by which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal. BP
GO:0048149 behavioral response to ethanol A change in the behavior of an organism as a result of an ethanol stimulus. BP
GO:0048148 behavioral response to cocaine A change in the behavior of an organism as a result of a cocaine stimulus. BP
GO:0048147 negative regulation of fibroblast proliferation Any process that stops, prevents or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. BP
GO:0048146 positive regulation of fibroblast proliferation Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. BP
GO:0048145 regulation of fibroblast proliferation Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. BP
GO:0048144 fibroblast proliferation The multiplication or reproduction of fibroblast cells, resulting in the rapid expansion of the fibroblast population. BP
GO:0048143 astrocyte activation A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0048142 cystoblast division (sensu Insecta) The four rounds of incomplete mitosis undergone by the cystoblast to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048141 female germ-line stem cell division (sensu Insecta) The asymmetric division of a germ-line stem cell in the ovary, to produce a new stem cell and a cystoblast. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048140 male germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad. BP
GO:0002001 renin secretion into blood stream The regulated release of renin into the blood stream by juxtoglomerular cells. BP
GO:0042721 mitochondrial inner membrane protein insertion complex A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane. CC
GO:0042720 mitochondrial inner membrane peptidase complex Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space. CC
GO:0042723 thiamin and derivative metabolic process The chemical reactions and pathways involving thiamin (vitamin B1), and compounds derived from it. BP
GO:0042722 alpha-beta T cell activation by superantigen The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region. BP
GO:0042725 thiamin and derivative catabolic process The chemical reactions and pathways resulting in the breakdown of thiamin (vitamin B1), and compounds derived from it. BP
GO:0042724 thiamin and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), and related compounds. BP
GO:0042727 riboflavin and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2) or any of its derivatives. BP
GO:0042726 riboflavin and derivative metabolic process The chemical reactions and pathways involving riboflavin (vitamin B2) or any of its derivatives. BP
GO:0042729 DASH complex A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. Associating with microtubules and kinetochores, the complex plays a role chromosome segregation and spindle stability. CC
GO:0042728 riboflavin and derivative catabolic process The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2) or any of its derivatives. BP
GO:0042899 arabinose polymer transport The directed movement of an arabinose polymer, a repeating chain of arabinose monomers, into, out of, within or between cells. BP
GO:0042898 fosmidomycin transporter activity Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of, within or between cells. MF
GO:0042893 polymyxin transport The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of, within or between cells. BP
GO:0042892 chloramphenicol transport The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of, within or between cells. BP
GO:0042891 antibiotic transport The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells. BP
GO:0042890 3-phenylpropionic acid transporter activity Enables the directed movement of 3-phenylpropionic acid into, out of, within or between cells. MF
GO:0042897 polymyxin transporter activity Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of, within or between cells. MF
GO:0042896 chloramphenicol transporter activity Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of, within or between cells. MF
GO:0042895 antibiotic transporter activity The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells. MF
GO:0042894 fosmidomycin transport The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of, within or between cells. BP
GO:0002005 angiotensin catabolic process in blood The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood. BP
GO:0050319 tartrate decarboxylase activity Catalysis of the reaction: (R,R)-tartrate = D-glycerate + CO2. MF
GO:0050318 tannase activity Catalysis of the reaction: digallate + H2O = 2 gallate. MF
GO:0050317 tagatose kinase activity Catalysis of the reaction: ATP + D-tagatose = ADP + D-tagatose 6-phosphate. MF
GO:0050316 T2-induced deoxynucleotide kinase activity Catalysis of the reaction: ATP + dGMP (or dTMP) = ADP + dGDP (or dTDP). MF
GO:0050315 synephrine dehydratase activity Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-(methylamino)ethanol = (4-hydroxyphenyl)acetaldehyde + methylamine. MF
GO:0050314 sym-norspermidine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + propane-1,3-diamine = 5'-methylthioadenosine + bis(3-aminopropyl)amine. MF
GO:0050313 sulfur dioxygenase activity Catalysis of the reaction: sulfur + O2 + H2O = SO3(2-) (sulfite). MF
GO:0050312 sulfoacetaldehyde lyase activity Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + SO3(2-) (sulfite). MF
GO:0050311 sulfite reductase (ferredoxin) activity Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = SO3(2-) (sulfite) + 3 reduced ferredoxin. MF
GO:0050310 sulfite dehydrogenase activity Catalysis of the reaction: SO3(2-) (sulfite) + 2 ferricytochrome c + H2O = SO4(2-) (sulfate) + 2 ferrocytochrome c. MF
GO:0018560 protocatechuate 3,4-dioxygenase type II activity Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate. MF
GO:0018561 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate. MF
GO:0018562 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid. MF
GO:0018563 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate. MF
GO:0018564 carbazole 1,9a-dioxygenase activity Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol. MF
GO:0018565 dihydroxydibenzothiophene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. MF
GO:0018566 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate. MF
GO:0018567 styrene dioxygenase activity Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol. MF
GO:0018568 3,4-dihydroxyphenanthrene dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate. MF
GO:0018569 hydroquinone 1,2-dioxygenase activity Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde. MF
GO:0019211 phosphatase activator activity Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. MF
GO:0019210 kinase inhibitor activity Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. MF
GO:0019213 deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. MF
GO:0019212 phosphatase inhibitor activity Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. MF
GO:0019215 intermediate filament binding Interacting selectively with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. MF
GO:0019217 regulation of fatty acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. BP
GO:0019216 regulation of lipid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. BP
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. BP
GO:0019218 regulation of steroid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. BP
GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. BP
GO:0007161 calcium-independent cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction. BP
GO:0007162 negative regulation of cell adhesion Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion. BP
GO:0007163 establishment and/or maintenance of cell polarity The specification, formation and maintenance of anisotropic intracellular organization or cell growth patterns. BP
GO:0007164 establishment of tissue polarity Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. BP
GO:0007165 signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell. BP
GO:0007166 cell surface receptor linked signal transduction Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. BP
GO:0007167 enzyme linked receptor protein signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase. BP
GO:0007168 receptor guanylyl cyclase signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity. BP
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. BP
GO:0052269 positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052268 negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052265 induction by organism of defense-related calcium ion flux in other organism during symbiotic interaction The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052264 induction by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction The activation by an organism of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052267 negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052266 negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052261 negative regulation by organism of defense response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052260 negative regulation by organism of inflammatory response of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052263 induction by organism of defense-related nitric oxide production in other organism during symbiotic interaction The activation by an organism of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052262 induction by organism of phytoalexin production in other organism during symbiotic interaction The activation by an organism of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0050628 2-oxopropyl-CoM reductase (carboxylating) activity Catalysis of the reaction: 2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+. MF
GO:0018609 chlorobenzene dioxygenase activity Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene). MF
GO:0018608 1-indanone dioxygenase activity Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone. MF
GO:0018601 4-nitrophenol 2-monooxygenase activity Catalysis of the reaction: p-nitrophenol + O2 + NADH + H+ = H2O + 4-nitrocatechol + NAD+. MF
GO:0018600 alpha-pinene dehydrogenase activity Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol. MF
GO:0018603 nitrobenzene 1,2-dioxygenase activity Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + NO2(-) (nitrite) + catechol. MF
GO:0018602 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid = glyoxylate + 2,4-dichlorophenol. MF
GO:0018605 2-aminobenzenesulfonate dioxygenase activity Catalysis of the reaction: toluene-4-sulfonate + NADH + H+ + O2 = NAD+ + HSO3(-) + 4-methylcatechol. MF
GO:0018604 4-aminobenzoate 3,4-dioxygenase (deaminating) activity Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate. MF
GO:0018607 1-indanone monooxygenase activity Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin. MF
GO:0018606 benzenesulfonate dioxygenase activity Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol. MF
GO:0005654 nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus. CC
GO:0005655 nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. CC
GO:0002684 positive regulation of immune system process Any process that activates or increases the frequency, rate, or extent of an immune system process. BP
GO:0002685 regulation of leukocyte migration Any process that modulates the frequency, rate, or extent of leukocyte migration. BP
GO:0005652 nuclear lamina The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. CC
GO:0051974 negative regulation of telomerase activity Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). BP
GO:0002246 healing during inflammatory response The series of events that restore integrity to damaged tissue during or following an inflammatory response. BP
GO:0017076 purine nucleotide binding Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. MF
GO:0017075 syntaxin-1 binding Interacting selectively with the SNAP receptor syntaxin-1. MF
GO:0051518 positive regulation of bipolar cell growth Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. BP
GO:0051519 activation of bipolar cell growth Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell. BP
GO:0051512 positive regulation of unidimensional cell growth Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis. BP
GO:0051513 regulation of monopolar cell growth Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. BP
GO:0051510 regulation of unidimensional cell growth Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis. BP
GO:0051511 negative regulation of unidimensional cell growth Any process that stops, prevents or reduces the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis. BP
GO:0051516 regulation of bipolar cell growth Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. BP
GO:0051517 negative regulation of bipolar cell growth Any process that stops, prevents or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. BP
GO:0051514 negative regulation of monopolar cell growth Any process that stops, prevents or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. BP
GO:0051515 positive regulation of monopolar cell growth Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. BP
GO:0015408 ferric-transporting ATPase activity Catalysis of the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in). MF
GO:0002247 clearance of damaged tissue during inflammatory response The series of events leading to removal of necrotic debris during or following an inflammatory response. BP
GO:0017071 intracellular cyclic nucleotide activated cation channel complex NA CC
GO:0015400 low affinity ammonium transporter activity NA MF
GO:0015401 urea:sodium symporter activity Catalysis of the reaction: urea(out) + Na+(out) = urea(in) + Na+(in). MF
GO:0015402 thiamin permease activity NA MF
GO:0015403 thiamin uptake transporter activity NA MF
GO:0015404 ion-gradient-driven energizer activity NA MF
GO:0015405 P-P-bond-hydrolysis-driven transporter activity Catalysis of the transport of a solute, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. MF
GO:0015407 monosaccharide-transporting ATPase activity Catalysis of the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported. MF
GO:0016170 interleukin-15 receptor binding Interacting selectively with the interleukin-15 receptor. MF
GO:0016175 superoxide-generating NADPH oxidase activity Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. MF
GO:0016174 NAD(P)H oxidase activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + H2O2. MF
GO:0016176 superoxide-generating NADPH oxidase activator activity Increases the activity of the enzyme superoxide-generating NADPH oxidase. MF
GO:0046258 anaerobic 2,4,6-trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen. BP
GO:0046254 anaerobic toluene catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen. BP
GO:0046256 2,4,6-trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. BP
GO:0046251 limonene catabolic process The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. BP
GO:0046250 limonene biosynthetic process The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene. BP
GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity Catalysis of the reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate. MF
GO:0030273 melanin-concentrating hormone receptor activity Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity. MF
GO:0030270 formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity Catalysis of the reaction: formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + N5-formyl-5,6,7,8-tetrahydromethanopterin. MF
GO:0030271 chymase activity Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa. MF
GO:0030276 clathrin binding Interacting selectively with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. MF
GO:0030277 maintenance of gastrointestinal epithelium Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. BP
GO:0030274 LIM domain binding Interacting selectively with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. MF
GO:0030275 LRR domain binding Interacting selectively with a LRR domain (leucine rich repeats) of a protein. MF
GO:0030278 regulation of ossification Any process that modulates the frequency, rate or extent of bone formation. BP
GO:0030279 negative regulation of ossification Any process that stops, prevents or reduces the frequency, rate or extent of bone formation. BP
GO:0002240 response to molecule of oomycetes origin A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of molecules of oomycetes origin. BP
GO:0046369 galactose biosynthetic process The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose. BP
GO:0016336 establishment and/or maintenance of polarity of larval imaginal disc epithelium The specification, formation and maintenance of a polarized larval imaginal disc epithelium. BP
GO:0046367 allose catabolic process The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. BP
GO:0002358 B cell homeostatic proliferation The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus. BP
GO:0046366 allose biosynthetic process The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. BP
GO:0002359 B-1 B cell proliferation The rapid expansion of a B-1 B cell by cell division. Follows B cell activation. BP
GO:0035091 phosphoinositide binding Interacting selectively with any inositol-containing glycerophospholipid. MF
GO:0035090 maintenance of apical/basal cell polarity Retaining the established polarization of a cell along its apical/basal axis. BP
GO:0035093 spermatogenesis, exchange of chromosomal proteins The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin. BP
GO:0002353 plasma kallikrein-kinin cascade A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. BP
GO:0035095 behavioral response to nicotine A change in the behavior of an organism as a result of a nicotine stimulus. BP
GO:0035094 response to nicotine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. BP
GO:0035097 histone methyltransferase complex A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. CC
GO:0035096 larval midgut cell programmed cell death The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ. BP
GO:0031635 opioid receptor, adenylate cyclase inhibiting pathway The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. BP
GO:0031634 replication fork barrier binding Interacting selectively with replication fork barriers, sites that inhibit the progress of replication forks. MF
GO:0031637 regulation of neuronal synaptic plasticity in response to neurotrophin The process by which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. BP
GO:0031636 adrenocorticotropin-releasing hormone receptor activity Combining with adrenocorticotropin-releasing hormone to initiate a change in cell activity. MF
GO:0031631 negative regulation of synaptic vesicle fusion to presynaptic membrane Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. BP
GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. BP
GO:0031633 xanthophore A chromatophore containing yellow pigment. CC
GO:0031632 positive regulation of synaptic vesicle fusion to presynaptic membrane Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. BP
GO:0031639 plasminogen activation The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds. BP
GO:0031638 zymogen activation The proteolytic processing of an inactive enzyme to an active form. BP
GO:0018619 benzene 1,2-dioxygenase activity Catalysis of the reaction: benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+. MF
GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. BP
GO:0002858 regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. BP
GO:0002853 negative regulation of T cell mediated cytotoxicity directed against tumor cell target Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. BP
GO:0002852 regulation of T cell mediated cytotoxicity directed against tumor cell target Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. BP
GO:0002851 positive regulation of peripheral T cell tolerance induction Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction. BP
GO:0002850 negative regulation of peripheral T cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction. BP
GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. BP
GO:0002856 negative regulation of natural killer cell mediated immune response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. BP
GO:0002855 regulation of natural killer cell mediated immune response to tumor cell Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell. BP
GO:0002854 positive regulation of T cell mediated cytotoxicity directed against tumor cell target Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target. BP
GO:0009755 hormone-mediated signaling A series of molecular signals mediated by the detection of a hormone. BP
GO:0009754 detection of jasmonic acid stimulus The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule. BP
GO:0009757 hexose mediated signaling A series of molecular signals mediated by the detection of hexose. BP
GO:0009756 carbohydrate mediated signaling A series of molecular signals mediated by the detection of carbohydrate. BP
GO:0009751 response to salicylic acid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. BP
GO:0009750 response to fructose stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. BP
GO:0009753 response to jasmonic acid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. BP
GO:0009752 detection of salicylic acid stimulus The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal. BP
GO:0009759 indole glucosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan. BP
GO:0009758 carbohydrate utilization Series of processes that involve carbohydrate sensing, carbohydrate transportation and carbohydrate metabolism which lead to the utilization of carbohydrates. BP
GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I. BP
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. BP
GO:0002585 positive regulation of antigen processing and presentation of peptide antigen Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen. BP
GO:0002584 negative regulation of antigen processing and presentation of peptide antigen Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen. BP
GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. BP
GO:0002586 regulation of antigen processing and presentation of peptide antigen via MHC class II Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. BP
GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. BP
GO:0002580 regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. BP
GO:0002583 regulation of antigen processing and presentation of peptide antigen Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. BP
GO:0002582 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. BP
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. MF
GO:0008409 5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. MF
GO:0008402 aromatase activity Catalysis of the reaction: R-H + reduced flavoprotein + O2 = R-OH + oxidized flavoprotein + H2O. MF
GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity Catalysis of the hydroxylation of C-24 of 25-hydroxycalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycalciferol. MF
GO:0008401 retinoic acid 4-hydroxylase activity NA MF
GO:0008406 gonad development The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. BP
GO:0008407 bristle morphogenesis The process by which the anatomical structures of the bristle are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0008404 arachidonic acid 14,15-epoxygenase activity NA MF
GO:0008405 arachidonic acid 11,12-epoxygenase activity NA MF
GO:0045489 pectin biosynthetic process The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. BP
GO:0045488 pectin metabolic process The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. BP
GO:0045481 6-endo-hydroxycineole dehydrogenase activity Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + NADH + H+. MF
GO:0045480 galactose oxidase activity Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + H2O2. MF
GO:0045483 aristolochene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate. MF
GO:0045482 trichodiene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = trichodiene + diphosphate. MF
GO:0045485 omega-6 fatty acid desaturase activity Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain. MF
GO:0045484 L-lysine 6-transaminase activity Catalysis of the reaction: L-lysine + 2-oxoglutarate = 2-aminoadipate 6-semialdehyde + L-glutamate. MF
GO:0045487 gibberellic acid catabolic process The chemical reactions and pathways resulting in the breakdown of gibberellic acid. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. BP
GO:0045486 naringenin 3-dioxygenase activity Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2. MF
GO:0047393 glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity Catalysis of the reaction: H2O + glycerol 1,2-cyclic phosphate = glycerol-3-phosphate. MF
GO:0042140 late meiotic recombination nodule assembly The assembly of small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over. BP
GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanol-amine + 1-alkyl-sn-glycerol 3-phosphate. MF
GO:0047390 glycerophosphocholine cholinephosphodiesterase activity Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = phosphoryl-choline + glycerol. MF
GO:0047397 dolichylphosphate-glucose phosphodiesterase activity Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose. MF
GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate. MF
GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity Catalysis of the reaction: H2O + sn-glycero-3-phospho-1-inositol = glycerol-3-phosphate + inositol. MF
GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol. MF
GO:0042149 cellular response to glucose starvation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. BP
GO:0042148 strand invasion The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. BP
GO:0047399 glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate. MF
GO:0047398 dolichylphosphate-mannose phosphodiesterase activity Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose. MF
GO:0045733 acetate catabolic process The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. BP
GO:0045732 positive regulation of protein catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. BP
GO:0045730 respiratory burst A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. BP
GO:0045737 positive regulation of cyclin-dependent protein kinase activity Any process that activates or increases the frequency, rate or extent of CDK activity. BP
GO:0045736 negative regulation of cyclin-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity. BP
GO:0045735 nutrient reservoir activity Functions in the storage of nutritious substrates. MF
GO:0045734 regulation of acetate catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. BP
GO:0045739 positive regulation of DNA repair Any process that activates or increases the frequency, rate or extent of DNA repair. BP
GO:0045738 negative regulation of DNA repair Any process that stops, prevents or reduces the frequency, rate or extent of DNA repair. BP
GO:0047645 alkan-1-ol dehydrogenase (acceptor) activity Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor. MF
GO:0047644 alizarin 2-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + alizarin = UDP + 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone. MF
GO:0047647 alkylacetylglycerophosphatase activity Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-alkyl-2-acetyl-sn-glycerol + phosphate. MF
GO:0047646 alkanal monooxygenase (FMN-linked) activity Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light. MF
GO:0047641 aldose-6-phosphate reductase (NADPH) activity Catalysis of the reaction: D-sorbitol 6-phosphate + NADP+ = D-glucose 6-phosphate + NADPH. MF
GO:0047640 aldose 1-dehydrogenase activity Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH. MF
GO:0047643 alginate synthase activity Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1). MF
GO:0047642 aldose beta-D-fructosyltransferase activity Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside. MF
GO:0047649 alkylglycerol kinase activity Catalysis of the reaction: ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate. MF
GO:0047648 alkylamidase activity Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylamine. MF
GO:0046118 7-methylguanosine biosynthetic process The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. BP
GO:0046119 7-methylguanosine catabolic process The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA. BP
GO:0046112 nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. BP
GO:0046113 nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. BP
GO:0046110 xanthine metabolic process The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. BP
GO:0046111 xanthine biosynthetic process The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. BP
GO:0046116 queuosine metabolic process The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. BP
GO:0046117 queuosine catabolic process The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. BP
GO:0046114 guanosine biosynthetic process The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution. BP
GO:0046115 guanosine catabolic process The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution. BP
GO:0002008 excitation of vasomotor center by chemoreceptor signaling The process by which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure. BP
GO:0002009 morphogenesis of an epithelium The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium is a sheet of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. BP
GO:0048848 neurohypophysis morphogenesis The process by which the anatomical structures of neurohypophysis are generated and organized. Morphogenesis pertains to the creation of form. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. BP
GO:0048849 neurohypophysis formation The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. BP
GO:0005056 tiggrin receptor activity NA MF
GO:0005057 receptor signaling protein activity NA MF
GO:0048844 artery morphogenesis The process by which the anatomical structures of arterial blood vessels are generated and organized. Morphogenesis pertains to the creation of form. Arteries are blood vessels that transport blood from the heart to the body and its organs. BP
GO:0002003 angiotensin maturation The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood. BP
GO:0005052 peroxisome targeting signal-1 binding Interacting selectively with a type 1 peroxisome targeting signal, a tripeptide with the consensu thes (S/A/C)-(K/R/H)-L. MF
GO:0005053 peroxisome targeting signal-2 binding Interacting selectively with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensu thes sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). MF
GO:0002006 vasopressin mediated vasoconstriction during blood pressure control The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream. BP
GO:0048841 regulation of axon extension involved in axon guidance Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. BP
GO:0048268 clathrin cage assembly Assembly of clathrin triskelia into clathrin cage. BP
GO:0048269 methionine adenosyltransferase complex A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules. CC
GO:0048262 determination of dorsoventral asymmetry Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis. BP
GO:0048263 determination of dorsal identity Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0048260 positive regulation of receptor mediated endocytosis Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. BP
GO:0048261 negative regulation of receptor mediated endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. BP
GO:0048266 behavioral response to pain A change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. BP
GO:0048264 determination of ventral identity The regionalization process by which the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0048265 response to pain A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. BP
GO:0052409 metabolism by organism of cell wall cellulose in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052408 metabolism by host of symbiont cell wall cellulose The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052405 negative regulation by host of symbiont protein function Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052404 negative regulation by host of symbiont protease activity Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052407 metabolism by organism of carbohydrate in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052406 metabolism by host of symbiont carbohydrate The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052400 induction by organism of programmed cell death in other organism during symbiotic interaction The activation by an organism of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052403 negative regulation by host of symbiont enzyme activity Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0003843 1,3-beta-glucan synthase activity Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). MF
GO:0006830 high-affinity zinc ion transport NA BP
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. MF
GO:0003840 gamma-glutamyltransferase activity Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. MF
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. MF
GO:0003846 2-acylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. MF
GO:0003845 11-beta-hydroxysteroid dehydrogenase activity Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+. MF
GO:0003844 1,4-alpha-glucan branching enzyme activity Catalysis of the transfer of a segment of a 1,4-a-D-glucan chain to a primary hydroxyl group in a similar glucan chain. MF
GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. BP
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate. MF
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. MF
GO:0019530 taurine metabolic process The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. BP
GO:0019531 oxalate transporter activity Enables the directed movement of oxalate into, out of, within or between cells. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. MF
GO:0019532 oxalate transport The directed movement of oxalate into, out of, within or between cells. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. BP
GO:0019533 cellobiose transport The directed movement of cellobiose into, out of, within or between cells. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. BP
GO:0019534 toxin transporter activity Enables the directed movement of a toxin into, out of, within or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. MF
GO:0019535 ferric-vibriobactin transporter activity Enables the directed movement of ferric-vibriobactin ions into, out of, within or between cells. MF
GO:0019536 vibriobactin metabolic process The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae. BP
GO:0019537 vibriobactin biosynthetic process The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae. BP
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. BP
GO:0019539 siderophore biosynthetic process from hydroxamic acid The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid. BP
GO:0042916 alkylphosphonate transport The directed movement of an alkylphosphonate into, out of, within or between cells. BP
GO:0042917 alkylphosphonate transporter activity Enables the directed movement of an alkylphosphonate into, out of, within or between cells. MF
GO:0042914 colicin transport The directed movement of a colicin into, out of, within or between cells. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. BP
GO:0042915 group A colicin transport The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of, within or between cells. BP
GO:0004095 carnitine O-palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. MF
GO:0042913 group A colicin transporter activity Enables the directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of, within or between cells. MF
GO:0042910 xenobiotic transporter activity Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells. MF
GO:0004096 catalase activity Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. MF
GO:0004099 chitin deacetylase activity Catalysis of the reaction: chitin + H2O = chitosan + acetate. MF
GO:0004098 cerebroside-sulfatase activity Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + SO4(2-) (sulfate). MF
GO:0042918 alkanesulfonate transport The directed movement of an alkanesulfonate into, out of, within or between cells. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. BP
GO:0042919 benzoate transport The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of, within or between cells. BP
GO:0000578 embryonic axis specification Axis specification in the embryo. BP
GO:0050298 stizolobinate synthase activity Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. MF
GO:0050299 streptomycin 3''-kinase activity Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 3''-phosphate. MF
GO:0050292 steroid 9-alpha-monooxygenase activity Catalysis of the reaction: pregna-4,9(11)-diene-3,20-dione + donor-H2 + O2 = 9,11-alpha-epoxypregn-4-ene-3,20-dione + acceptor + H2O. MF
GO:0050293 steroid-lactonase activity Catalysis of the reaction: testololactone + H2O = testolate. MF
GO:0050290 sphingomyelin phosphodiesterase D activity Catalysis of the reaction: sphingomyelin + H2O = ceramide phosphate + choline. MF
GO:0050291 sphingosine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae, either dihydrosphingosine (DHS) or phytosphingosine (PHS) can react with C26-fattyacyl-CoA to produce ceramide-I or ceramide-II (also called phytoceramide) respectively. In mammals, DHS is usually acylated with a C18 fatty acid group. MF
GO:0050296 stipitatonate decarboxylase activity Catalysis of the reaction: stipitatonate = stipitatate + CO2. MF
GO:0050297 stizolobate synthase activity Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. MF
GO:0050294 steroid sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. MF
GO:0050295 steryl-beta-glucosidase activity Catalysis of the reaction: H2O + cholesteryl-beta-D-glucoside = D-glucose + cholesterol. MF
GO:0042794 rRNA transcription from plastid promoter The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase. BP
GO:0019398 gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 4-carboxy-2-hydroxhexa-2,3-dienedioate. BP
GO:0019399 cyclohexanol oxidation NA BP
GO:0004216 cathepsin K activity Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. MF
GO:0019394 glucarate catabolic process The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid. BP
GO:0019395 fatty acid oxidation The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. BP
GO:0019396 gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). BP
GO:0019397 gallate catabolic process via 2-pyrone-4,6-dicarboxylate The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate. BP
GO:0019390 glucuronoside biosynthetic process The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. BP
GO:0004215 cathepsin H activity Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase. MF
GO:0019392 glucarate metabolic process The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate. BP
GO:0019393 glucarate biosynthetic process The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid. BP
GO:0004214 dipeptidyl-peptidase I activity Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro. MF
GO:0042790 transcription of nuclear rRNA large RNA polymerase I transcript The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template. BP
GO:0050128 N-feruloylglycine deacylase activity Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine. MF
GO:0050129 N-formylglutamate deformylase activity Catalysis of the reaction: N-formyl-L-glutamate + H2O = formate + L-glutamate. MF
GO:0050124 N-acylneuraminate-9-phosphatase activity Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. MF
GO:0050125 N-benzyloxycarbonylglycine hydrolase activity Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O = benzyl alcohol + CO2 + glycine. MF
GO:0050126 N-carbamoylputrescine amidase activity Catalysis of the reaction: H2O + N-carbamoylputrescine = NH3 + CO2 + putrescine. MF
GO:0050127 N-carbamoylsarcosine amidase activity Catalysis of the reaction: N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3. MF
GO:0050120 N-acetylhexosamine 1-dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + N-acetyl-D-glucosamine = NADH + N-acetyl-D-glucosaminate. MF
GO:0050121 N-acylglucosamine 2-epimerase activity Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine. MF
GO:0050122 N-acylhexosamine oxidase activity Catalysis of the reaction: H2O + O2 + N-acetyl-D-glucosamine = H2O2 + N-acetyl-D-glucosaminate. MF
GO:0050123 N-acylmannosamine 1-dehydrogenase activity Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + NADH. MF
GO:0005879 axonemal microtubule A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. CC
GO:0051459 regulation of adrenocorticotropic hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells. BP
GO:0051458 adrenocorticotropin hormone secretion The regulated release of adrenocorticotropin hormone, also known as corticotropin, by a cell or group of cells. Adrenocorticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. BP
GO:0005870 actin capping protein of dynactin complex A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex. CC
GO:0005871 kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. CC
GO:0005872 minus-end kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule. CC
GO:0005873 plus-end kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule. CC
GO:0051457 maintenance of protein localization in nucleus The processes by which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. BP
GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. CC
GO:0051455 attachment of spindle microtubules to kinetochore during meiosis I The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs. BP
GO:0051454 cellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. BP
GO:0016548 rRNA editing The insertion, deletion or substitution of nucleotides within nascent rRNA transcripts to produce rRNA molecules with sequences that differ from those coded genetically. BP
GO:0043550 regulation of lipid kinase activity Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. BP
GO:0051989 coproporphyrinogen dehydrogenase activity Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine. MF
GO:0051988 regulation of attachment of spindle microtubules to kinetochore Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. BP
GO:0051985 negative regulation of chromosome segregation Any process that stops, prevents or reduces the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. BP
GO:0051984 positive regulation of chromosome segregation Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. BP
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. BP
GO:0051986 negative regulation of attachment of spindle microtubules to kinetochore Any process that stops, prevents or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. BP
GO:0051981 copper chelate transporter activity Enables the directed movement of a copper chelate into, out of, within or between cells. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. MF
GO:0051980 iron-nicotianamine transporter activity Enables the directed movement of the iron chelate iron-nicotianamine (Fe-NA) into, out of, within or between cells. MF
GO:0051983 regulation of chromosome segregation Any process that modulates the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. BP
GO:0051982 copper-nicotianamine transporter activity Enables the directed movement of the copper chelate copper-nicotianamine (Cu-NA) into, out of, within or between cells. MF
GO:0016540 protein autoprocessing Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. BP
GO:0005153 interleukin-8 receptor binding Interacting selectively with the interleukin-8 receptor. MF
GO:0005152 interleukin-1 receptor antagonist activity Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. MF
GO:0048761 collenchyma cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occuring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles. BP
GO:0048760 parenchymal cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasts. They vary in size, form, and wall structure. BP
GO:0005157 macrophage colony stimulating factor receptor binding Interacting selectively with the macrophage colony stimulating factor receptor. MF
GO:0005156 epidermal growth factor receptor inhibiting ligand activity NA MF
GO:0052188 modification of cellular component in other organism during symbiotic interaction The process by which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052189 modulation by symbiont of defense-related host cell wall callose deposition Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0048765 root hair cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a root hair cell. BP
GO:0052180 negative regulation of protease activity in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052181 modulation by host of symbiont defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052182 modification by host of symbiont morphology or physiology via secreted substance The process by which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0048764 trichoblast maturation A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state. BP
GO:0052185 modification of structure of other organism during symbiotic interaction The process by which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052186 modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction The alteration by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052187 modification by host of symbiont cellular component The process by which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0005159 insulin-like growth factor receptor binding Interacting selectively with the insulin-like growth factor receptor. MF
GO:0048768 root hair cell tip growth Localized growth of a plant root hair tip by extension of the cell wall. BP
GO:0045186 zonula adherens assembly Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. BP
GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of alkyl compounds containing a hydroxyl group. BP
GO:0006067 ethanol metabolic process The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. BP
GO:0006064 glucuronate catabolic process The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. BP
GO:0047978 hexadecanol dehydrogenase activity Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH. MF
GO:0006062 sorbitol catabolic process The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. BP
GO:0006063 uronic acid metabolic process The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. BP
GO:0006060 sorbitol metabolic process The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. BP
GO:0006061 sorbitol biosynthetic process The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group. BP
GO:0006068 ethanol catabolic process The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. BP
GO:0006069 ethanol oxidation NA BP
GO:0010258 NADH dehydrogenase complex (plastoquinone) assembly The formation of NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I. BP
GO:0010259 multicellular organismal aging Progression of a multicellular organism from its inception to the end of its lifespan. BP
GO:0010252 auxin homeostasis Maintenance of endogenous concentration of primary auxin equilibrium, or constant level of auxin in a biological system by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation. BP
GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. BP
GO:0010250 S-methylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle. BP
GO:0010256 endomembrane organization The assembly and arrangement of endomembrane systems. BP
GO:0010257 NADH dehydrogenase complex assembly The formation of NADH dehydrogenase complex. BP
GO:0010254 nectary development The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure. BP
GO:0010255 glucose mediated signaling The process by which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes. BP
GO:0015619 thiamin pyrophosphate-transporting ATPase activity Catalysis of the reaction: ATP + H2O + thiamin pyrophosphate(out) = ADP + phosphate + thiamin pyrophosphate(in). MF
GO:0047409 alkenylglycerophosphoethanolamine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde. MF
GO:0047408 alkenylglycerophosphocholine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde. MF
GO:0015611 D-ribose-importing ATPase activity Catalysis of the reaction: ATP + H2O + D-ribose(out) = ADP + phosphate + D-ribose(in). MF
GO:0015610 glycerol phosphate-importing ATPase activity Catalysis of the reaction: ATP + H2O + glycerol-phosphate(out) = ADP + phosphate + glycerol-phosphate(in). MF
GO:0047401 trithionate hydrolase activity Catalysis of the reaction: H2O + trithionate = 2 H+ + SO4(2-) (sulfate) + S2O3(2-). MF
GO:0015612 L-arabinose-importing ATPase activity Catalysis of the reaction: ATP + H2O + L-arabinose(out) = ADP + phosphate + L-arabinose(in). MF
GO:0015615 D-allose-importing ATPase activity Catalysis of the reaction: ATP + H2O + D-allose(out) = ADP + phosphate + D-allose(in). MF
GO:0015614 D-xylose-importing ATPase activity Catalysis of the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in). MF
GO:0047405 pyrimidine-5'-nucleotide nucleosidase activity Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine. MF
GO:0015616 DNA translocase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the transport of DNA. MF
GO:0043579 elaioplast organization and biogenesis The assembly and arrangement of a elaioplast, a leucoplast in which oil is stored. BP
GO:0043578 nuclear matrix organization and biogenesis The assembly and arrangement of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane. BP
GO:0043573 leucoplast fission The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes. BP
GO:0043572 plastid fission The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. BP
GO:0043571 maintenance of CRISPR repeat elements Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. BP
GO:0043570 maintenance of DNA repeat elements Any process involved in sustaining the fidelity and copy number of DNA repeat elements. BP
GO:0043577 chemotropism The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it. BP
GO:0043576 regulation of respiratory gaseous exchange Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. BP
GO:0043575 detection of osmotic stimulus The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal. BP
GO:0043574 peroxisomal transport Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. BP
GO:0045809 positive regulation of establishment of competence for transformation Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation. BP
GO:0045808 negative regulation of establishment of competence for transformation Any process that stops, prevents or reduces the frequency, rate or extent of establishment of competence for transformation. BP
GO:0045805 positive regulation of eclosion Any process that activates or increases the frequency, rate or extent of eclosion. BP
GO:0045804 negative regulation of eclosion Any process that stops, prevents or reduces the frequency, rate or extent of eclosion. BP
GO:0045807 positive regulation of endocytosis Any process that activates or increases the frequency, rate or extent of endocytosis. BP
GO:0045806 negative regulation of endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of endocytosis. BP
GO:0045801 positive regulation of cuticle tanning Any process that activates or increases the frequency, rate or extent of cuticular tanning. BP
GO:0045800 negative regulation of cuticle tanning Any process that stops, prevents or reduces the frequency, rate or extent of cuticular tanning. BP
GO:0030755 quercetin 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone. MF
GO:0030754 apigenin 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone. MF
GO:0030757 3-methylquercitin 7-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxy-3-methoxyflavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,7-dimethoxy-flavone. MF
GO:0030756 isoorientin 3'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoorientin = S-adenosyl-L-homocysteine + isoscoparin. MF
GO:0030751 licodione 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = S-adenosyl-L-homocysteine + N-methylputrescine. MF
GO:0030750 putrescine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = S-adenosyl-L-homocysteine + N-methylputrescine. MF
GO:0030753 8-hydroxyfuranocoumarin 8-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 8-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 8-methoxyfuranocoumarin. MF
GO:0030752 5-hydroxyfuranocoumarin 5-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin. MF
GO:0030759 methylquercetagetin 6-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,6-tetrahydroxy-3,7-dimethoxy-flavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,6,7-trimethoxyflavone. MF
GO:0030758 3,7-dimethylquercitin 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5-trihydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 3',5-dihydroxy-3,4',7-trimethoxy-flavone. MF
GO:0045113 regulation of integrin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. BP
GO:0045112 integrin biosynthetic process The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules. BP
GO:0045111 intermediate filament cytoskeleton Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. CC
GO:0045110 intermediate filament bundle assembly The formation of the bundles of intermediate filaments, known as tonofilaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs. BP
GO:0045117 azole transport The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of, within or between cells. BP
GO:0045116 protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. BP
GO:0045115 regulation of beta 2 integrin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins. BP
GO:0045114 beta 2 integrin biosynthetic process The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit. BP
GO:0045119 azole:hydrogen antiporter activity Catalysis of the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances. MF
GO:0045118 azole transporter activity Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of, within or between cells. MF
GO:0047986 hydrogen-sulfide S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + hydrogen sulfide = CoA + thioacetate. MF
GO:0047987 hydroperoxide dehydratase activity Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O. MF
GO:0047985 hydrogen dehydrogenase activity Catalysis of the reaction: H2 + NAD+ = H+ + NADH. MF
GO:0047982 homocysteine desulfhydrase activity Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. MF
GO:0047983 homoglutathione synthase activity Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + beta-alanine = ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine. MF
GO:0047980 hippurate hydrolase activity Catalysis of the reaction: hippurate + H2O = benzoate + glycine. MF
GO:0047981 histidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + L-histidine = CoA + N-acetyl-L-histidine. MF
GO:0047988 hydroxyacid-oxoacid transhydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. MF
GO:0047989 hydroxybutyrate-dimer hydrolase activity Catalysis of the reaction: (R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate. MF
GO:0018937 nitroglycerin metabolic process The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates. BP
GO:0018936 anaerobic nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen. BP
GO:0018935 aerobic nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen. BP
GO:0018934 nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment. BP
GO:0018933 nicotine metabolic process The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine. BP
GO:0018931 naphthalene metabolic process The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide. BP
GO:0018930 3-methylquinoline metabolic process The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. BP
GO:0018939 n-octane metabolic process The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System. BP
GO:0018938 2-nitropropane metabolic process The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol. BP
GO:0008305 integrin complex Any member of a family of heterodimeric transmembrane receptors for cell-adhesion molecules. The alpha and beta subunits are noncovalently bonded. CC
GO:0008307 structural constituent of muscle The action of a molecule that contributes to the structural integrity of a muscle fiber. MF
GO:0008306 associative learning Learning by associating a stimulus (the cause) with a particular outcome (the effect). BP
GO:0008301 DNA bending activity The function of causing local conformational micropolymorphism of DNA in which the original B-DNA structure is only distorted but not extensively modified. MF
GO:0008300 isoprenoid catabolic process The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. BP
GO:0008303 caspase complex A cytosolic endopeptidase with specificity for the hydrolysis of aspartyl bonds. Caspases are involved in apoptosis. CC
GO:0008302 ring canal formation, actin assembly Recruitment and organization of actin filaments in female ring canals. BP
GO:0008309 double-stranded DNA specific exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. MF
GO:0008308 voltage-gated ion-selective channel activity NA MF
GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. BP
GO:0031409 pigment binding Interacting selectively with a pigment, any general or particular coloring matter in living organisms, e.g. melanin. MF
GO:0031402 sodium ion binding Interacting selectively with sodium ions (Na+). MF
GO:0031403 lithium ion binding Interacting selectively with lithium ions (Li+). MF
GO:0031400 negative regulation of protein modification Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. BP
GO:0031401 positive regulation of protein modification Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. BP
GO:0031406 carboxylic acid binding Interacting selectively with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). MF
GO:0031407 oxylipin metabolic process The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. BP
GO:0031404 chloride ion binding Interacting selectively with chloride ions (Cl-). MF
GO:0031405 lipoic acid binding Interacting selectively with lipoic acid, 1,2-dithiolane-3-pentanoic acid. MF
GO:0032274 gonadotropin secretion The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone. BP
GO:0032275 luteinizing hormone secretion The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. BP
GO:0032276 regulation of gonadotropin secretion Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. BP
GO:0032277 negative regulation of gonadotropin secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a gonadotropin. BP
GO:0032270 positive regulation of cellular protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. BP
GO:0032271 regulation of protein polymerization Any process that modulates the frequency, rate or extent of the process of creating protein polymers. BP
GO:0032272 negative regulation of protein polymerization Any process that stops, prevents or reduces the frequency, rate or extent of the process of creating protein polymers. BP
GO:0032273 positive regulation of protein polymerization Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. BP
GO:0032278 positive regulation of gonadotropin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin. BP
GO:0032279 asymmetric synapse A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. CC
GO:0015307 drug:hydrogen antiporter activity Catalysis of the reaction: H+(out) + drug(in) = H+(in) + drug(out). MF
GO:0015306 sialate:cation symporter activity Catalysis of the reaction: sialate(out) + cation(out) = sialate(in) + cation(in). MF
GO:0015304 glucose uniporter activity Catalysis of the reaction: glucose(out) = glucose(in). MF
GO:0007421 stomatogastric nervous system development The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure. BP
GO:0052183 modification by host of symbiont structure The process by which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0007420 brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). BP
GO:0015301 anion:anion antiporter activity Catalysis of the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). MF
GO:0032188 establishment of contractile ring localization The process by which a contractile ring is assembled in a specific location. BP
GO:0032189 maintenance of contractile ring localization The processes by which a contractile ring is maintained in a location and prevented from moving elsewhere. BP
GO:0032186 bud neck septin ring organization Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck. BP
GO:0032187 contractile ring localization The process by which a contractile ring is assembled and/or maintained in a specific location. BP
GO:0032184 SUMO polymer binding Interacting selectively with a polymer of the small ubiquitin-like protein SUMO. MF
GO:0009662 etioplast organization and biogenesis The assembly and arrangement of the etioplast. BP
GO:0032182 small conjugating protein binding Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. MF
GO:0032183 SUMO binding Interacting selectively with the small ubiquitin-like protein SUMO. MF
GO:0032180 ubiquinone biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate. BP
GO:0032181 dinucleotide repeat insertion binding Interacting selectively with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats. MF
GO:0015002 heme-copper terminal oxidase activity Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane. MF
GO:0047814 D-arabinokinase activity Catalysis of the reaction: ATP + D-arabinose = ADP + D-arabinose 5-phosphate. MF
GO:0042336 cuticle biosynthetic process during molting (sensu Protostomia and Nematoda) Synthesis and deposition of a noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317), and the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0042337 cuticle biosynthetic process during molting (sensu Insecta) The synthesis and deposition of a noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0042334 taxis to electron acceptor The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate. BP
GO:0042335 cuticle biosynthetic process The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss. BP
GO:0042332 gravitaxis The directed movement of a motile cell or organism in response to gravity. BP
GO:0042333 chemotaxis to oxidizable substrate The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose. BP
GO:0042330 taxis The directed movement of a motile cell or organism in response to an external stimulus. BP
GO:0042331 phototaxis The directed movement of a motile cell or organism in response to light. BP
GO:0042338 cuticle biosynthetic process during molting (sensu Nematoda) Synthesis and deposition of a noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0042339 keratan sulfate metabolic process The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. BP
GO:0006264 mitochondrial DNA replication The process whereby new strands of DNA are synthesized in the mitochondrion. BP
GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. BP
GO:0006266 DNA ligation The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. BP
GO:0006267 pre-replicative complex formation The assembly of the pre-replicative complex, multiprotein complex that forms at eukaryotic DNA replication origins during late M phase; its presence is required for replication initiation. BP
GO:0006260 DNA replication The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. BP
GO:0006261 DNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. BP
GO:0006268 DNA unwinding during replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. BP
GO:0006269 DNA replication, synthesis of RNA primer The generation, by DNA polymerase alpha, of an RNA primer followed by a short segment of DNA on the lagging strand of the replicating DNA. BP
GO:0005795 Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. CC
GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. CC
GO:0005797 Golgi medial cisterna The middle Golgi cisterna (or cisternae). CC
GO:0005796 Golgi lumen The volume enclosed by the membranes of any cisterna of the Golgi apparatus. CC
GO:0005791 rough endoplasmic reticulum The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. CC
GO:0005790 smooth endoplasmic reticulum The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. CC
GO:0000318 protein-methionine-R-oxide reductase activity Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. MF
GO:0000319 sulfite transporter activity Enables the directed movement of sulfite ions into, out of, within or between cells. MF
GO:0000316 sulfite transport The directed movement of sulfite into, out of, within or between cells. BP
GO:0000317 methionine-S-oxide reductase activity Catalysis of the reaction: L-methionine S-oxide + thioredoxin = L-methionine + thioredoxin disulfide. Thioredoxin disulfide is the oxidized form of thioredoxin. No reaction on oxidized methionine in peptide linkage. MF
GO:0000314 organellar small ribosomal subunit The smaller of the two subunits of an organellar ribosome. CC
GO:0000315 organellar large ribosomal subunit The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). CC
GO:0000312 plastid small ribosomal subunit The smaller of the two subunits of a plastid ribosome. CC
GO:0000313 organellar ribosome A ribosome contained within a subcellular organelle. CC
GO:0000310 xanthine phosphoribosyltransferase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate; substrate specificity for xanthine. MF
GO:0000311 plastid large ribosomal subunit The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). CC
GO:0043668 exine The outer layer of the pollen grain wall which is composed primarily of sporopollenin. CC
GO:0052421 metabolism by organism of xylan in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0050708 regulation of protein secretion Any process that modulates the frequency, rate or extent of the regulated release of a protein from a cell or group of cells. BP
GO:0050709 negative regulation of protein secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a protein from a cell or group of cells. BP
GO:0050704 regulation of interleukin-1 secretion Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells. BP
GO:0050705 regulation of interleukin-1 alpha secretion Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells. BP
GO:0050706 regulation of interleukin-1 beta secretion Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells. BP
GO:0050707 regulation of cytokine secretion Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells. BP
GO:0050700 CARD domain binding Interacting selectively with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. MF
GO:0050701 interleukin-1 secretion The regulated release of interleukin-1 from a cell or group of cells. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response. BP
GO:0050702 interleukin-1 beta secretion The regulated release of interleukin 1 beta from a cell or group of cells. BP
GO:0050703 interleukin-1 alpha secretion The regulated release of interleukin-1 alpha from a cell or group of cells. BP
GO:0001701 embryonic development (sensu Mammalia) The process whose specific outcome is the progression of the embryo over time, from formation of the zygote to birth. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0002219 activation of innate immune response (sensu Viridiplantae) Any process that initiates an innate immune response as in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). BP
GO:0002218 activation of innate immune response Any process that initiates an innate immune response. BP
GO:0005249 voltage-gated potassium channel activity NA MF
GO:0005248 voltage-gated sodium channel activity NA MF
GO:0002211 behavioral defense response to insect A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism. BP
GO:0005246 calcium channel regulator activity NA MF
GO:0002213 defense response to insect A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. BP
GO:0002212 behavioral defense response to nematode A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism. BP
GO:0005243 gap-junction forming channel activity NA MF
GO:0005242 inward rectifier potassium channel activity NA MF
GO:0048651 polyphenic determination, influence by environmental factors The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues. BP
GO:0048650 caste determination, influence by environmental factors The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. BP
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. MF
GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. MF
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. MF
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. MF
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin. MF
GO:0004110 corticosteroid side-chain-isomerase activity Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al. MF
GO:0004111 creatine kinase activity Catalysis of the reaction: ATP + creatine = ADP + phosphocreatine. MF
GO:0004112 cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. MF
GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. MF
GO:0001544 initiation of primordial ovarian follicle growth Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle). BP
GO:0018091 peptidyl-asparagine racemization The racemization of peptidyl-asparagine. BP
GO:0001546 preantral ovarian follicle growth Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation. BP
GO:0001547 antral ovarian follicle growth Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity. BP
GO:0018094 protein polyglycylation The posttranslational addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid. BP
GO:0018095 protein polyglutamylation The posttranslational addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. BP
GO:0018096 peptide cross-linking via S-(2-aminovinyl)-D-cysteine The posttranslational synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine. BP
GO:0018097 protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine. BP
GO:0001548 follicular fluid formation in ovarian follicle antrum Formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells. BP
GO:0001549 cumulus cell differentiation The process whereby a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell. BP
GO:0030733 fatty-acid O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester. MF
GO:0030732 methionine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine. MF
GO:0030731 guanidinoacetate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine. MF
GO:0030730 sequestering of triacylglycerol The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. BP
GO:0001898 regulation by symbiont of cytolysis of host cells Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0001899 negative regulation by symbiont of cytolysis of host cells Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0001896 autolysis The spontaneous death by lysis of bacteria in response to environmental conditions. BP
GO:0001897 cytolysis by symbiont of host cells The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0001894 tissue homeostasis Any of the processes involved in the maintenance of an internal equilibrium within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. BP
GO:0001895 retinal homeostasis Any of the processes involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. BP
GO:0001892 embryonic placenta development The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. BP
GO:0001893 maternal placenta development Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. BP
GO:0001890 placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. BP
GO:0001891 phagocytic cup An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. CC
GO:0030735 carnosine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine. MF
GO:0030734 polysaccharide O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units. MF
GO:0002165 larval or pupal development (sensu Insecta) The process whose specific outcome is the progression of the larva or pupa over time, from its formation to the mature structure. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0002164 larval development The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of any animal when more or less of a metamorphosis takes place, before the assumption of the mature shape. BP
GO:0016720 delta12-fatty acid dehydrogenase activity Catalysis of the reaction: linoleate + donor-H2 + O2 = crepenynate + acceptor + H2O. MF
GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor. MF
GO:0016722 oxidoreductase activity, oxidizing metal ions Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. MF
GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. MF
GO:0016724 oxidoreductase activity, oxidizing metal ions, oxygen as acceptor Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor. MF
GO:0016725 oxidoreductase activity, acting on CH2 groups Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016726 oxidoreductase activity, acting on CH2 groups, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. MF
GO:0016727 oxidoreductase activity, acting on CH2 groups, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. MF
GO:0016728 oxidoreductase activity, acting on CH2 groups, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. MF
GO:0021586 pons maturation A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. BP
GO:0021587 cerebellum morphogenesis The process by which the anatomical structure of the cerebellum is generated and organized. Morphogenesis pertains to the creation of form. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. BP
GO:0021584 pons formation The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. BP
GO:0021585 pons structural organization The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. BP
GO:0021582 medulla oblongata maturation A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. BP
GO:0021583 pons morphogenesis The process by which the anatomical structure of the pons is generated and organized. Morphogenesis pertains to the creation of form. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. BP
GO:0021580 medulla oblongata formation The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. BP
GO:0021581 medulla oblongata structural organization The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. BP
GO:0021588 cerebellum formation The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. BP
GO:0021589 cerebellum structural organization The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. BP
all all This term is the most general term possible universal
GO:0015969 guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. BP
GO:0015968 stringent response A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation. BP
GO:0015963 diadenosine triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. BP
GO:0015962 diadenosine triphosphate metabolic process The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. BP
GO:0015961 diadenosine polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. BP
GO:0015960 diadenosine polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. BP
GO:0015967 diadenosine tetraphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. BP
GO:0015966 diadenosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. BP
GO:0015965 diadenosine tetraphosphate metabolic process The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached. BP
GO:0015964 diadenosine triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. BP
GO:0017189 N-terminal peptidyl-alanine acetylation The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase. BP
GO:0017188 aspartate N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + L-aspartate = CoA + N-acetyl-L-aspartate. MF
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine The posttranslational modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2. BP
GO:0017182 peptidyl-diphthamide metabolic process The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue. BP
GO:0017181 peptidyl-diphthine catabolic process The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue. BP
GO:0017180 peptidyl-diphthine biosynthetic process from peptidyl-histidine The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine. BP
GO:0017187 peptidyl-glutamic acid carboxylation The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. BP
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase. BP
GO:0017185 peptidyl-lysine hydroxylation The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine. BP
GO:0017184 peptidyl-diphthamide catabolic process The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue. BP
GO:0016654 oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a disulfide group. MF
GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. MF
GO:0021962 vestibulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord. BP
GO:0021963 spinothalamic tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal processes is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling. BP
GO:0021965 spinal cord ventral commissure morphogenesis The process by which the anatomical structures of the spinal cord ventral commissure are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0016652 oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. MF
GO:0021967 corticospinal neuron axon neuron guidance through the cerebral cortex The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues. BP
GO:0052391 induction by symbiont of defense-related host calcium ion flux The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052390 induction by symbiont of host innate immunity The activation by an organism of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052393 induction by host of symbiont defense response The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052397 induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction Any process by which an organism activates programmed cell death by a non-apoptotic pathway in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0008148 negative transcription elongation factor activity Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. MF
GO:0008143 poly(A) binding Interacting selectively with the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. MF
GO:0008142 oxysterol binding Interacting selectively with oxysterol, an oxidized form of cholesterol. MF
GO:0008140 cAMP response element binding protein binding NA MF
GO:0008147 structural constituent of bone The action of a molecule that contributes to the structural integrity of bone. MF
GO:0008146 sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. MF
GO:0008145 phenylalkylamine binding Interacting selectively with phenylalkylamine or any of its derivatives. MF
GO:0008144 drug binding Interacting selectively with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. MF
GO:0043684 type IV protein secretion system complex A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of nucleoprotein DNA conjugation intermediates or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s). CC
GO:0043681 protein import into mitochondrion The directed movement of a protein from the cytoplasm to the mitochondrion. BP
GO:0043680 filiform apparatus A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells. CC
GO:0043683 type IV pilus biogenesis The assembly of a type IV pilus, composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation. BP
GO:0043682 copper-transporting ATPase activity Catalysis of the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane. MF
GO:0045210 FasL biosynthetic process The chemical reactions and pathways resulting in the formation of FasL (CD95), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines. BP
GO:0045211 postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane. CC
GO:0045212 neurotransmitter receptor biosynthetic process The chemical reactions and pathways resulting in the formation of neurotransmitter receptors. BP
GO:0045213 neurotransmitter receptor metabolic process The chemical reactions and pathways involving neurotransmitter receptors. BP
GO:0045214 sarcomere organization The organization of the muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. BP
GO:0045216 intercellular junction assembly and maintenance The assembly and maintenance of junctions between cells. BP
GO:0045217 intercellular junction maintenance The maintenance of junctions between cells. BP
GO:0045218 zonula adherens maintenance Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells. BP
GO:0045219 regulation of FasL biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL. BP
GO:0015138 fumarate transporter activity Enables the directed movement of fumarate into, out of, within or between cells. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. MF
GO:0015139 alpha-ketoglutarate transporter activity Enables the directed movement of alpha-ketoglutarate into, out of, within or between cells. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. MF
GO:0015130 mevalonate transporter activity Enables the directed movement of mevalonate into, out of, within or between cells. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds. MF
GO:0015131 oxaloacetate transporter activity Enables the directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of, within or between cells. MF
GO:0015132 prostaglandin transporter activity Enables the directed movement of prostaglandins into, out of, within or between cells. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. MF
GO:0015133 uronic acid transporter activity Enables the directed movement of uronic acid into, out of, within or between cells. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. MF
GO:0015134 hexuronate transporter activity Enables the directed movement of hexuronates into, out of, within or between cells. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. MF
GO:0015135 glucuronate transporter activity Enables the directed movement of glucuronate into, out of, within or between cells. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. MF
GO:0015136 sialic acid transporter activity Enables the directed movement of sialic acid into, out of, within or between cells. MF
GO:0015137 citrate transporter activity Enables the directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells. MF
GO:0019168 2-octaprenylphenol hydroxylase activity Catalysis of the reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol. MF
GO:0019162 pyridoxamine-oxaloacetate transaminase activity Catalysis of the reaction: pyridoxamine + oxaloacetate = pyridoxal + L-aspartate. MF
GO:0016449 lambda DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). A DNA-directed DNA polymerase that may be specific to lymphoid cells and play a role in the somatic hypermutation of antibody genes. MF
GO:0016448 mu DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). A DNA-directed DNA polymerase that may be specific to lymphoid cells and play a role in the somatic hypermutation of antibody genes. MF
GO:0016441 posttranscriptional gene silencing The inactivation of gene expression by a posttranscriptional mechanism. BP
GO:0016443 bidentate ribonuclease III activity Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference. MF
GO:0016442 RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. CC
GO:0016445 somatic diversification of immunoglobulins The somatic process by means of which sequence diversity of immunoglobulins is generated. BP
GO:0016444 somatic cell DNA recombination Recombination occurring within or between DNA molecules in somatic cells. BP
GO:0016447 somatic recombination of immunoglobulin gene segments The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. BP
GO:0016446 somatic hypermutation of immunoglobulin genes Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. BP
GO:0043308 eosinophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil. BP
GO:0043309 regulation of eosinophil degranulation Any process that modulates the frequency, rate, or extent of eosinophil degranulation. BP
GO:0043300 regulation of leukocyte degranulation Any process that modulates the frequency, rate, or extent of leukocyte degranulation. BP
GO:0043301 negative regulation of leukocyte degranulation Any process that stops, prevents, or reduces the rate of leukocyte degranulation. BP
GO:0043302 positive regulation of leukocyte degranulation Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. BP
GO:0043303 mast cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. BP
GO:0043304 regulation of mast cell degranulation Any process that modulates the frequency, rate, or extent of mast cell degranulation. BP
GO:0043305 negative regulation of mast cell degranulation Any process that stops, prevents, or reduces the rate of mast cell degranulation. BP
GO:0043306 positive regulation of mast cell degranulation Any process that activates or increases the frequency, rate or extent of mast cell degranulation. BP
GO:0043307 eosinophil activation The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. BP
GO:0009957 epidermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0009956 radial pattern formation The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur. BP
GO:0009955 adaxial/abaxial pattern formation The regionalization process by which differences in cell differentiation along the adaxial (adjacent to the stem) / abaxial (away from the stem) are generated. BP
GO:0009954 proximal/distal pattern formation The regionalization process by which specific areas of cell differentiation are determined along a proximal/distal axis. BP
GO:0009953 dorsal/ventral pattern formation The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. BP
GO:0009952 anterior/posterior pattern formation The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. BP
GO:0009951 polarity specification of dorsal/ventral axis The processes resulting in the establishment of polarity along the dorsal/ventral axis. BP
GO:0009950 dorsal/ventral axis specification The establishment, maintenance and elaboration of the dorsal/ventral axis. BP
GO:0009959 negative gravitropism The orientation of plant parts away from gravity. BP
GO:0009958 positive gravitropism The orientation of plant parts towards gravity. BP
GO:0031305 integral to mitochondrial inner membrane Penetrating at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031304 intrinsic to mitochondrial inner membrane Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031307 integral to mitochondrial outer membrane Penetrating at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031306 intrinsic to mitochondrial outer membrane Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031301 integral to organelle membrane Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031300 intrinsic to organelle membrane Located in an organelle membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031303 integral to endosome membrane Penetrating at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031302 intrinsic to endosome membrane Located in the endosome membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031309 integral to nuclear outer membrane Penetrating at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0031308 intrinsic to nuclear outer membrane Located in the nuclear outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0050429 calcium-dependent phospholipase C activity Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate; requires Ca2+. MF
GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. BP
GO:0050425 carboxypeptidase B activity Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid. MF
GO:0050424 alanine carboxypeptidase activity Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups. MF
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. BP
GO:0050426 peptidyl-glycinamidase activity Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide. MF
GO:0050421 nitrite reductase (NO-forming) activity Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = NO2(-) (nitrite) + ferrocytochrome c + 2 H+. MF
GO:0050420 maltose synthase activity Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate. MF
GO:0050423 thiamin oxidase activity Catalysis of the reaction: thiamin + 2 O2 = thiamin acetic acid + 2 H2O2. MF
GO:0050422 strictosidine beta-glucosidase activity Catalysis of the reaction: H2O + strictosidine = D-glucose + strictosidine aglycone. MF
GO:0050397 Watasenia-luciferin 2-monooxygenase activity Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light. MF
GO:0050396 vomifoliol 4'-dehydrogenase activity Catalysis of the reaction: NAD+ + (+-)-6-hydroxy-3-oxo-alpha-ionol = NADH + (+-)-6-hydroxy-3-oxo-alpha-ionone. MF
GO:0050395 vitexin beta-glucosyltransferase activity Catalysis of the reaction: vitexin + UDP-D-glucose = vitexin 2'-O-beta-D-glucoside + UDP. MF
GO:0050394 viomycin kinase activity Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin. MF
GO:0050393 vinylacetyl-CoA delta-isomerase activity Catalysis of the reaction: vinylacetyl-CoA = crotonyl-CoA. MF
GO:0050392 vicianin beta-glucosidase activity Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose. MF
GO:0050391 valine dehydrogenase (NADP) activity Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH. MF
GO:0050390 valine decarboxylase activity Catalysis of the reaction: L-valine = 2-methylpropanamine + CO2. MF
GO:0050399 xanthommatin reductase activity Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = xanthommatin + NADH. MF
GO:0050398 wax-ester hydrolase activity Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate. MF
GO:0018872 arsonoacetate metabolic process The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides. BP
GO:0018873 atrazine metabolic process The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide. BP
GO:0018870 anaerobic 2-aminobenzoate metabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen. BP
GO:0018871 1-aminocyclopropane-1-carboxylate metabolic process The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. BP
GO:0018876 benzonitrile metabolic process The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin. BP
GO:0018877 beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health. BP
GO:0018874 benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. BP
GO:0018875 anaerobic benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen. BP
GO:0018878 aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen. BP
GO:0018879 biphenyl metabolic process The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). BP
GO:0032025 response to cobalt ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. BP
GO:0032024 positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. BP
GO:0032027 myosin light chain binding Interacting selectively with a light chain of a myosin complex. MF
GO:0032026 response to magnesium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. BP
GO:0032021 NELF complex A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing. CC
GO:0032020 ISG15-protein conjugation The covalent addition to a protein of ISG15, a ubiquitin-like protein. BP
GO:0032023 trypsinogen activation The proteolytic processing of trypsinogen to the active form, trypsin. BP
GO:0032022 pellicle formation A process whereby microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface. BP
GO:0032029 myosin tail binding Interacting selectively with the tail region of a myosin heavy chain. MF
GO:0032028 myosin head/neck binding Interacting selectively with the head/neck region of a myosin heavy chain. MF
GO:0031231 intrinsic to peroxisomal membrane Located in the peroxisomal membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031230 intrinsic to outer membrane (sensu ProteoBacteria) Located in the outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0031233 intrinsic to external side of plasma membrane Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. CC
GO:0031232 extrinsic to external side of plasma membrane Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region. CC
GO:0000929 gamma-tubulin large complex (sensu SchizoSaccharomyces) A multiprotein complex composed of gamma-tubulin and other conserved non-tubulin proteins. Complex size is heterogenous but is around 2000kDa (or greater than 20S) and is comparable to the vertebrate gamma-tubulin large complex. As in, but not restricted to, the taxon Schizosaccharomyces (Schizosaccharomyces, ncbi_taxonomy_id:4895). CC
GO:0000928 gamma-tubulin complex (sensu Saccharomyces) A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). CC
GO:0000925 gamma-tubulin ring complex, centrosomal (sensu Metazoa) A multiprotein complex that composed of approximately 10-14 gamma-tubulin molecules and at least six other non-tubulin proteins assembled into a flexible open ring structure, which in animal cells has a diameter of around 25nm. It is thought to be the unit of nucleation at the minus end of a microtubule. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). CC
GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. CC
GO:0000927 gamma-tubulin small complex (sensu Metazoa) A complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). CC
GO:0000926 gamma-tubulin large complex (sensu Metazoa) A complex thought to be formed by multimerization of gamma-tubulin small complexes. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). CC
GO:0000921 septin ring assembly Assembly and organization of septins and associated proteins into a structure resembling a ring at the cell cortex. BP
GO:0000920 cell separation during cytokinesis The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components. BP
GO:0000923 equatorial microtubule organizing center A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis. CC
GO:0031234 extrinsic to internal side of plasma membrane Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region. CC
GO:0031237 intrinsic to external side of plasma membrane, in periplasmic space Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space. CC
GO:0031236 extrinsic to external side of plasma membrane, in periplasmic space Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region. CC
GO:0019835 cytolysis The rupture of cell membranes and the loss of cytoplasm. BP
GO:0019834 phospholipase A2 inhibitor activity Stops, prevents or reduces the activity of the enzyme phospholipase A2. MF
GO:0019836 hemolysis by symbiont of host red blood cells The processes by which an organism effects hemolysis, the lytic destruction of red blood cells with the release of intracellular hemoglobin, in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0002431 Fc receptor mediated stimulatory signaling pathway A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. BP
GO:0002430 complement receptor mediated signaling pathway A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway. BP
GO:0002433 phagocytosis triggered by activation of immune response cell surface activating receptor Phagocytosis occurring as the result of a ligand binding an immune response cell surface activating receptor. BP
GO:0002432 granuloma formation The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic. BP
GO:0002435 immune complex clearance by erythrocytes The process of immune complex clearance by erythrocytes. BP
GO:0019838 growth factor binding Interacting selectively with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. MF
GO:0002437 inflammatory response to antigenic stimulus An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. BP
GO:0002436 immune complex clearance by monocytes and macrophages The process of immune complex clearance by monocytes or macrophages. BP
GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0035321 maintenance of wing hair orientation Ensuring that hairs in the wing continue to point distally during development, following the initial establishment of wing hair polarity. BP
GO:0035320 wing hair site selection Determination of the site in the cell at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally. BP
GO:0005168 neurotrophin TRKA receptor binding Interacting selectively with the neurotrophin TRKA receptor. MF
GO:0005169 neurotrophin TRKB receptor binding Interacting selectively with the neurotrophin TRKB receptor. MF
GO:0048752 semicircular canal morphogenesis The process by which the anatomical structures of the semicircular canals are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048753 pigment granule organization and biogenesis The assembly and arrangement of a pigment granule. BP
GO:0048750 corneal lens morphogenesis (sensu Endopterygota) The process by which the anatomical structures of corneal lens are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0005161 platelet-derived growth factor receptor binding Interacting selectively with the platelet-derived growth factor receptor. MF
GO:0048756 sieve cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. BP
GO:0048757 pigment granule maturation Steps required to form a membrane bound organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. BP
GO:0005164 tumor necrosis factor receptor binding Interacting selectively with the tumor necrosis factor receptor. MF
GO:0005165 neurotrophin receptor binding Interacting selectively with a neurotrophin receptor. MF
GO:0000109 nucleotide-excision repair complex Any complex formed of proteins that act in nucleotide-excision repair. CC
GO:0000108 repairosome A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage. CC
GO:0000107 imidazoleglycerol-phosphate synthase activity Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate. MF
GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. BP
GO:0000104 succinate dehydrogenase activity Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. No reaction with quinols. MF
GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. BP
GO:0000102 L-methionine porter activity NA MF
GO:0000101 sulfur amino acid transport The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells. BP
GO:0000100 S-methylmethionine transporter activity Enables the directed movement of S-methylmethionine into, out of, within or between cells. MF
GO:0007458 progression of morphogenetic furrow (sensu Endopterygota) The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007459 photoreceptor fate commitment (sensu Endopterygota) The process during which the photoreceptors of the ommatidium commit to their cell fate. There are three classes of photoreceptor cells, R1-6, R7 and R8, which have different spectral sensitivities and express different photosensitive pigments. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0015338 cation diffusion facilitator activity Catalysis of the reaction: Me2+(in or out) = Me2+(out or in), powered by proton motive force. MF
GO:0007454 labial disc morphogenesis The process by which the anatomical structures derived from the labial disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis. BP
GO:0007455 eye-antennal disc morphogenesis The process by which the anatomical structures derived from the eye-antennal disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps. BP
GO:0015334 high affinity oligopeptide transporter activity NA MF
GO:0007450 dorsal/ventral pattern formation, imaginal disc The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. BP
GO:0015333 peptide:hydrogen symporter activity Catalysis of the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). MF
GO:0015330 high affinity glutamine permease activity NA MF
GO:0007453 clypeo-labral disc morphogenesis The process by which the anatomical structures derived from the clypeo-labral disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus. BP
GO:0019488 ribitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate. BP
GO:0019489 methylgallate metabolic process The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. BP
GO:0019484 beta-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. BP
GO:0019485 beta-alanine catabolic process to L-alanine The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine. BP
GO:0019486 beta-alanine catabolic process to mevalonate semialdehyde, by transamination The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination. BP
GO:0019487 anaerobic acetylene catabolic process The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen. BP
GO:0019480 L-alanine oxidation to pyruvate via D-alanine NA BP
GO:0019481 L-alanine catabolic process, by transamination The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination. BP
GO:0019482 beta-alanine metabolic process The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. BP
GO:0019483 beta-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. BP
GO:0051592 response to calcium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. BP
GO:0051593 response to folic acid A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. BP
GO:0051590 positive regulation of neurotransmitter transport Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells. BP
GO:0051591 response to cAMP A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. BP
GO:0051596 methylglyoxal catabolic process The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. BP
GO:0051597 response to methylmercury A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. BP
GO:0051594 detection of glucose The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal. BP
GO:0051595 response to methylglyoxal A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. BP
GO:0051598 meiotic recombination checkpoint A checkpoint during late prophase I (pachytene) which prevents segregation of homologous chromosomes until recombination is completed and ensures proper distribution of the genetic material to the gametes. BP
GO:0051599 response to hydrostatic pressure A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. BP
GO:0015481 maltose transporting porin activity NA MF
GO:0015482 voltage-gated anion channel porin activity NA MF
GO:0015483 long-chain fatty acid transporting porin activity NA MF
GO:0015485 cholesterol binding Interacting selectively with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. MF
GO:0015486 glycoside-pentoside-hexuronide:cation symporter activity Catalysis of the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+. MF
GO:0015487 melibiose permease activity Catalysis of the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in). MF
GO:0015488 glucuronide permease activity Catalysis of the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in). MF
GO:0015489 putrescine transporter activity Enables the directed movement of putrescine into, out of, within or between cells. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. MF
GO:0018681 deisopropylatrazine monooxygenase activity Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 CH3CHO + 2 deisopropyldeethylatrazine. MF
GO:0018680 deethylatrazine monooxygenase activity Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine. MF
GO:0018683 camphor 5-monooxygenase activity Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O. MF
GO:0018682 atrazine monooxygenase activity NA MF
GO:0018685 alkane 1-monooxygenase activity Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. MF
GO:0018684 camphor 1,2-monooxygenase activity Catalysis of the reaction: (+)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O. MF
GO:0018687 biphenyl 2,3-dioxygenase activity Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD; requires Fe2+. MF
GO:0018686 6-hydroxy pseudo-oxynicotine monooxygenase activity Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine. MF
GO:0018689 naphthalene disulfonate 1,2-dioxygenase activity Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene). MF
GO:0018688 DDT 2,3-dioxygenase activity Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT. MF
GO:0019156 isoamylase activity Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins. MF
GO:0019157 malate oxidase activity Catalysis of the reaction: (S)-malate + O2 = oxaloacetate + H2O2. MF
GO:0019154 glycolate dehydrogenase activity Catalysis of the reaction: glycolate + acceptor = glyoxylate + reduced acceptor. MF
GO:0019155 3-(imidazol-5-yl)lactate dehydrogenase activity Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+. MF
GO:0019152 acetoin dehydrogenase activity Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. MF
GO:0019153 protein-disulfide reductase (glutathione) activity Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. MF
GO:0019150 D-ribulokinase activity Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate. MF
GO:0019151 galactose 1-dehydrogenase activity Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+. MF
GO:0019158 mannokinase activity Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. MF
GO:0019159 nicotinamide-nucleotide amidase activity Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3. MF
GO:0021939 extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation. BP
GO:0051865 protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. BP
GO:0016689 manganese peroxidase activity Catalysis of the reaction: 2 Mn2+ + 2 H+ + H2O2 = 2 Mn3+ + 2 H2O. MF
GO:0016688 L-ascorbate peroxidase activity Catalysis of the reaction: L-ascorbate + H2O2 = dehydroascorbate + 2 H2O. MF
GO:0021933 radial glia guided migration of granule cell The inward migration of postmitotic granule cells along radial glial cells from the external granule layer to the internal granule cell layer. BP
GO:0021932 hindbrain radial glia guided cell migration The radially directed movement of cells along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain. BP
GO:0021931 rostral hindbrain neuronal precursor cell proliferation The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus. BP
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. MF
GO:0021937 Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation. BP
GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen. MF
GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome. MF
GO:0021934 hindbrain tangential cell migration The migration of cells in the hindbrain in which cells move orthogonal to the direction of radial migration. BP
GO:0052023 modulation by symbiont of salicylic acid levels in host The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052022 modulation by symbiont of jasmonic acid levels in host The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052021 modulation by symbiont of ethylene levels in host The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052020 modification by symbiont of host cell wall The process by which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052027 modulation by symbiont of host signal transduction pathway Any process by which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052026 modulation by symbiont of host transcription Any process by which an organism modulates the frequency, rate or extent of host transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052025 modification by symbiont of host cell membrane The process by which an organism effects a change in the structure or function of the host cell membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052024 positive regulation by symbiont of hormone or growth regulator levels in host The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052029 negative regulation by symbiont of host signal transduction pathway Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052028 positive regulation by symbiont of host signal transduction pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0050084 mannitol-1-phosphatase activity Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + phosphate. MF
GO:0031149 stalk cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a stalk cell, any of the cellulose-covered cells that form the stalk of a cellular slime mold fruiting body. BP
GO:0031148 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. BP
GO:0031143 pseudopodium A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. CC
GO:0031142 induction of conjugation upon nitrogen starvation The process by which a cell initiates conjugation with cellular fusion upon nitrogen starvation. BP
GO:0031141 induction of conjugation upon carbon starvation The process by which a cell initiates conjugation with cellular fusion upon carbon starvation. BP
GO:0031140 induction of conjugation upon nutrient starvation The process by which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients. BP
GO:0031147 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. BP
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. BP
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. BP
GO:0031144 proteasome localization The processes by which the proteasome is transported to, or maintained in, a specific location. BP
GO:0051839 regulation by host of cytolysis of symbiont cells Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051838 cytolysis by host of symbiont cells The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051831 growth or development within other organism during symbiotic interaction The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism. BP
GO:0051830 entry into other organism through barriers of other organism during symbiotic interaction Penetration by an organism into a second organism via active breaching of physical barriers, where the two organisms are in a symbiotic interaction. BP
GO:0051833 suppression of defenses of other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense(s) of a second organism, where the two organisms are in a symbiotic interaction. Suppression occurs by active mechanisms that normally result in the shutting down of pathways in the second organism. BP
GO:0051832 avoidance of defenses of other organism during symbiotic interaction Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction. BP
GO:0051835 positive regulation of synapse structural plasticity Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity. BP
GO:0051834 evasion or tolerance of defenses of other organism during symbiotic interaction Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction. Defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). BP
GO:0051837 translocation of DNA into other organism during symbiotic interaction The directed movement of DNA from an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051836 translocation of molecules into other organism during symbiotic interaction The directed movement of a molecule(s) produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0009429 flagellar basal body, proximal rod (sensu Bacteria) The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009428 flagellar basal body, distal rod, P ring (sensu Bacteria) One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009423 chorismate biosynthetic process The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds. BP
GO:0009422 flagellar hook-filament junction (sensu Bacteria) The region of the flagellum where the hook and filament meet. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009421 flagellar filament cap (sensu Bacteria) The proteinaceous structure at the distal tip of the flagellar filament. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009420 flagellar filament (sensu Bacteria) The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009427 flagellar basal body, distal rod, L ring (sensu Bacteria) One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009426 flagellar basal body, distal rod (sensu Bacteria) The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009425 flagellar basal body (sensu Bacteria) One of the three major substructures of the flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0009424 flagellar hook (sensu Bacteria) The portion of the flagellum that connects the filament to the basal body. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0005914 spot adherens junction A small junction assombled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens. CC
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) Catalysis of the removal of an acetyl group from lysine at position 16 of the histone H4 protein. MF
GO:0046972 histone acetyltransferase activity (H4-K16 specific) Catalysis of the addition of an acetyl group onto lysine at position 16 of the histone H4 protein. MF
GO:0046974 histone lysine N-methyltransferase activity (H3-K9 specific) Catalysis of the addition of a methyl group onto lysine at position 9 of the histone H3 protein. MF
GO:0046975 histone lysine N-methyltransferase activity (H3-K36 specific) Catalysis of the addition of a methyl group onto lysine at position 36 of the histone H3 protein. MF
GO:0046976 histone lysine N-methyltransferase activity (H3-K27 specific) Catalysis of the addition of a methyl group onto lysine at position 27 of the histone H3 protein. MF
GO:0046977 TAP binding Interacting selectively with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. MF
GO:0046978 TAP1 binding Interacting selectively with the TAP1 subunit of TAP (transporter associated with antigen processing) protein. MF
GO:0046979 TAP2 binding Interacting selectively with the TAP2 subunit of TAP (transporter associated with antigen processing) protein. MF
GO:0008482 sulfite oxidase activity Catalysis of the reaction: SO3(2-) (sulfite) + O2 + H2O = SO4(2-) (sulfate) + H2O2. MF
GO:0008483 transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. MF
GO:0008480 sarcosine dehydrogenase activity Catalysis of the reaction: sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor. MF
GO:0008481 sphinganine kinase activity Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. MF
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. MF
GO:0008487 prenyl-dependent CAAX protease activity NA MF
GO:0008484 sulfuric ester hydrolase activity Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. MF
GO:0008488 gamma-glutamyl carboxylase activity NA MF
GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + glucosylceramide = lactosylceramide (galactosyl-beta-1,4-glucosylceramide) + UDP. MF
GO:0045401 positive regulation of interleukin-3 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3. BP
GO:0045400 negative regulation of interleukin-3 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3. BP
GO:0045403 negative regulation of interleukin-4 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4. BP
GO:0045402 regulation of interleukin-4 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4. BP
GO:0045405 regulation of interleukin-5 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5. BP
GO:0045404 positive regulation of interleukin-4 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4. BP
GO:0045407 positive regulation of interleukin-5 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5. BP
GO:0045406 negative regulation of interleukin-5 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5. BP
GO:0045409 negative regulation of interleukin-6 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. BP
GO:0045408 regulation of interleukin-6 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. BP
GO:0048076 regulation of eye pigmentation (sensu Endopterygota) Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0030957 Tat protein binding Interacting selectively with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. MF
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex Complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. CC
GO:0030955 potassium ion binding Interacting selectively with potassium (K+) ions. MF
GO:0030954 astral microtubule nucleation The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. BP
GO:0030953 astral microtubule organization and biogenesis The assembly and arrangement of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. BP
GO:0030952 establishment and/or maintenance of cytoskeleton polarity The specification, formation and maintenance of polarized cytoskeletal structures. BP
GO:0030951 establishment and/or maintenance of microtubule cytoskeleton polarity The specification, formation and maintenance of polarized microtubule-based cytoskeletal structures. BP
GO:0030950 establishment and/or maintenance of actin cytoskeleton polarity The specification, formation and maintenance of polarized actin-based cytoskeletal structures. BP
GO:0030959 peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine The posttranslation modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link. BP
GO:0030958 RITS complex A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing. CC
GO:0047319 aspartate-phenylpyruvate transaminase activity Catalysis of the reaction: phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetic acid. MF
GO:0047313 aromatic-amino-acid-glyoxylate transaminase activity Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid. MF
GO:0047312 phenylalanine(histidine) transaminase activity Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine. MF
GO:0047311 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity Catalysis of the reaction: pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol = L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol. MF
GO:0047310 glutamine-scyllo-inositol transaminase activity Catalysis of the reaction: 2-keto-myo-inositol + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-keto-glutaramate. MF
GO:0047317 N6-acetyl-beta-lysine transaminase activity Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate. MF
GO:0047316 glutamine-phenylpyruvate transaminase activity Catalysis of the reaction: phenylpyruvate + L-glutamine = L-phenylalanine + 2-keto-glutaramate. MF
GO:0047315 kynurenine-glyoxylate transaminase activity Catalysis of the reaction: glyoxylate + kynurenine = L-glycine + 4-(2-aminophenyl)-2,4-dioxobutanoate. MF
GO:0050977 magnetoreception, using chemical stimulus The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli. BP
GO:0050976 detection of mechanical stimulus during sensory perception of touch The series of events during the perception of touch in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050975 sensory perception of touch The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). BP
GO:0050974 detection of mechanical stimulus during sensory perception The series of events in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050973 detection of mechanical stimulus during equilibrioception The series of events during equilibrioception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears. BP
GO:0050972 detection of mechanical stimulus during echolocation The series of events during echolocation in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave. BP
GO:0050971 detection of mechanical stimulus during magnetoreception The series of events during magnetoception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field. BP
GO:0050970 detection of electrical stimulus during magnetoreception The series of events during magnetoception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field. BP
GO:0050979 magnetoreception, using mechanical stimulus The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field. BP
GO:0050978 magnetoreception, using electrical stimulus The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish. BP
GO:0002738 positive regulation of plasmacytoid dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. BP
GO:0002739 regulation of cytokine secretion during immune response Any process that modulates the frequency, rate, or extent of cytokine secretion during immune response. BP
GO:0002736 regulation of plasmacytoid dendritic cell cytokine production Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. BP
GO:0002737 negative regulation of plasmacytoid dendritic cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production. BP
GO:0002734 negative regulation of myeloid dendritic cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production. BP
GO:0002735 positive regulation of myeloid dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. BP
GO:0002732 positive regulation of dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. BP
GO:0002733 regulation of myeloid dendritic cell cytokine production Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production. BP
GO:0002730 regulation of dendritic cell cytokine production Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production. BP
GO:0002731 negative regulation of dendritic cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. BP
GO:0044460 flagellar part Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium. CC
GO:0044461 flagellar part (sensu Bacteria) Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0044462 external encapsulating structure part Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. CC
GO:0044463 cell projection part Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. CC
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms. CC
GO:0046192 anaerobic phenol biosynthetic process The chemical reactions and pathways resulting in the formation of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. BP
GO:0046193 anaerobic phenol catabolic process The chemical reactions and pathways resulting in the breakdown of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. BP
GO:0046190 aerobic phenol biosynthetic process The chemical reactions and pathways resulting in the formation of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. BP
GO:0046191 aerobic phenol catabolic process The chemical reactions and pathways resulting in the breakdown of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. BP
GO:0046196 4-nitrophenol catabolic process The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. BP
GO:0046197 orcinol biosynthetic process The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. BP
GO:0046199 cresol catabolic process The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. BP
GO:0035121 tail morphogenesis The process by which the anatomical structures of the tail are generated and organized. Morphogenesis pertains to the creation of form. The tail is the hindmost part of some animals. BP
GO:0002081 outer acrosomal membrane The acrosomal region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction. CC
GO:0002082 regulation of oxidative phosphorylation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. BP
GO:0002083 4-hydroxybenzoate decaprenyltransferase activity Catalysis of the reaction: decaprenyl-PP + p-hydroxybenzoate = decaprenyl-4-hydroxybenzoate + diphosphate. MF
GO:0002084 protein depalmitoylation The removal of palymitoyl groups from a lipoprotein. BP
GO:0002085 repression of premature neural plate formation The process that prevents cells of the epiblast from differentiating into neuroepithelial cells before the appropriate time. BP
GO:0035127 post-embryonic limb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. BP
GO:0002087 neurological control of breathing The processes pertaining to the functions of the nervous system that are required for the proper control of respiratory gaseous exchange. These processes occur in the respiratory center of the brain in vertebrates. BP
GO:0002088 lens development (sensu Vertebrata) The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0002089 lens morphogenesis (sensu Vertebrata) The process by which the anatomical structures of the lens are generated and organized. Morphogenesis pertains to the creation of form. The lens is a transparent structure in the eye through which light is focused onto the retina. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0048598 embryonic morphogenesis The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific and may be somewhat arbitrary. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. BP
GO:0048599 oocyte development The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. BP
GO:0048590 non-developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass is does not have the specific outcome of the progression of the organism over time from one condition to another. BP
GO:0048591 non-developmental cell growth The growth of a cell prior to division, where the growth does not change the cell from one condition to another condition over time. BP
GO:0048592 eye morphogenesis The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048593 eye morphogenesis (sensu Vertebrata) The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0048594 eye morphogenesis (sensu Actinopterygii) The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the ray-finned fishes (Actinopterygii, ncbi_taxonomy_id:7898). BP
GO:0048595 eye morphogenesis (sensu Mammalia) The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0048596 embryonic eye morphogenesis (sensu Actinopterygii) The process by which the anatomical structures of the eye are generated and organized during embryonic development. Morphogenesis pertains to the creation of form. As in, but not restricted to, the ray-finned fishes (Actinopterygii, ncbi_taxonomy_id:7898). BP
GO:0048597 post-embryonic eye morphogenesis (sensu Actinopterygii) The process by which the anatomical structures of the eye are generated and organized during post-embryonic development. Morphogenesis pertains to the creation of form. As in, but not restricted to, the ray-finned fishes (Actinopterygii, ncbi_taxonomy_id:7898). BP
GO:0009852 auxin catabolic process The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth. BP
GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. BP
GO:0009850 auxin metabolic process The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth. BP
GO:0009851 auxin biosynthetic process The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. BP
GO:0009856 pollination Biological processes occurring in plants beginning when the pollen lands on the stigma and continuing up to, but not including, fertilization, as defined by sperm-central cell fusion. BP
GO:0009854 oxidative photosynthetic carbon pathway The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2). BP
GO:0009855 determination of bilateral symmetry The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. BP
GO:0043111 replication fork blocking Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. BP
GO:0043110 rDNA spacer replication fork barrier binding Interacting selectively with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription. MF
GO:0043113 receptor clustering Grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. BP
GO:0043112 receptor metabolic process The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. BP
GO:0043115 precorrin-2 dehydrogenase activity Catalysis of the reaction: precorrin-2 (dihydrosirohydrochlorin) + NAD+ = sirohydrochlorin + NADH + H+. MF
GO:0043114 regulation of vascular permeability Any process that modulates the extent to which blood vessels can be pervaded by fluid. BP
GO:0043117 positive regulation of vascular permeability Any process that increases the extent to which blood vessels can be pervaded by fluid. BP
GO:0043116 negative regulation of vascular permeability Any process that reduces the extent to which blood vessels can be pervaded by fluid. BP
GO:0042444 phenylethylamine biosynthetic process The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. BP
GO:0004366 glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. MF
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. MF
GO:0004364 glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. MF
GO:0004363 glutathione synthase activity Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. MF
GO:0004362 glutathione-disulfide reductase activity Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. MF
GO:0004361 glutaryl-CoA dehydrogenase activity Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor. MF
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. MF
GO:0042448 progesterone metabolic process The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. BP
GO:0004369 glycerol-3-phosphate oxidase activity Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2. MF
GO:0004368 glycerol-3-phosphate dehydrogenase activity Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. MF
GO:0008815 citrate (pro-3S)-lyase activity Catalysis of the reaction: citrate = acetate + oxaloacetate. MF
GO:0008814 citrate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. MF
GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin. MF
GO:0008816 citryl-CoA lyase activity Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. MF
GO:0008811 chloramphenicol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate. MF
GO:0008810 cellulase activity Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. MF
GO:0008813 chorismate pyruvate lyase activity Catalysis of the reaction: chorismate = p-hydroxybenzoate + pyruvate. MF
GO:0008812 choline dehydrogenase activity Catalysis of the reaction: choline + acceptor = betaine aldehyde + reduced acceptor. MF
GO:0008819 cobinamide kinase activity Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate. MF
GO:0008818 cobalamin 5'-phosphate synthase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP. MF
GO:0042998 positive regulation of Golgi to plasma membrane protein transport Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. BP
GO:0042999 regulation of Golgi to plasma membrane CFTR protein transport Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. BP
GO:0042996 regulation of Golgi to plasma membrane protein transport Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. BP
GO:0042997 negative regulation of Golgi to plasma membrane protein transport Any process that stops, prevents or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. BP
GO:0042994 cytoplasmic sequestering of transcription factor The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. BP
GO:0042995 cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon. CC
GO:0042992 negative regulation of transcription factor import into nucleus Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. BP
GO:0042993 positive regulation of transcription factor import into nucleus Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. BP
GO:0042990 regulation of transcription factor import into nucleus Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. BP
GO:0042991 transcription factor import into nucleus The directed movement of a transcription factor from the cytoplasm to the nucleus. BP
GO:0048029 monosaccharide binding Interacting selectively with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. MF
GO:0048024 regulation of nuclear mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of mRNA splicing. BP
GO:0006948 induction by virus of cell-cell fusion in host The process of syncytia-forming cell-cell fusion, caused by a virus. BP
GO:0019895 kinesin-associated mitochondrial adaptor activity The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria. MF
GO:0050212 progesterone 11-alpha-monooxygenase activity Catalysis of the reaction: progesterone + donor-H2 + O2 = 11-alpha-hydroxyprogesterone + acceptor + H2O. MF
GO:0050213 progesterone 5-alpha-reductase activity Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. MF
GO:0050210 prenyl-diphosphatase activity Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate. MF
GO:0050211 procollagen galactosyltransferase activity Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine. MF
GO:0050216 propanediol-phosphate dehydrogenase activity Catalysis of the reaction: propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH. MF
GO:0050217 propioin synthase activity Catalysis of the reaction: 2 propanal = 4-hydroxy-3-hexanone. MF
GO:0050214 progesterone monooxygenase activity Catalysis of the reaction: progesterone + donor-H2 + O2 = testosterone acetate + acceptor + H2O. MF
GO:0050215 propanediol dehydratase activity Catalysis of the reaction: propane-1,2-diol = propanal + H2O. MF
GO:0050218 propionate-CoA ligase activity Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA. MF
GO:0050219 prostaglandin-A1 delta-isomerase activity Catalysis of the reaction: (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate. MF
GO:0018447 chloral hydrate dehydrogenase activity Catalysis of the reaction: chloral hydrate = 3 H+ + 2 e- + trichloroacetate OR chloral hydrate + H2 = H2O + trichloroethanol. MF
GO:0018446 pinocarveol dehydrogenase activity Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-. MF
GO:0018445 prothoracicotrophic hormone activity NA MF
GO:0018444 translation release factor complex A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome. CC
GO:0018443 enzyme active site formation via L-aspartic 4-phosphoric anhydride The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride. BP
GO:0018442 peptidyl-glutamic acid esterification NA BP
GO:0018441 iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase. BP
GO:0018449 1-phenylethanol dehydrogenase activity Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2. MF
GO:0018448 hydroxymethylmethylsilanediol oxidase activity Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O. MF
GO:0019314 D-allose metabolic process The chemical reactions and pathways involving D-allose, the dextrorotatory isomer of D-allo-hexose, an aldohexose similar to glucose. BP
GO:0019315 D-allose biosynthetic process The chemical reactions and pathways resulting in the formation of D-allose, the dextrorotatory isomer of D-allo-hexose, an aldohexose similar to glucose. BP
GO:0019316 D-allose catabolic process The chemical reactions and pathways resulting in the breakdown of D-allose, the dextrorotatory isomer of D-allo-hexose, an aldohexose similar to glucose. BP
GO:0019317 fucose catabolic process The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose). BP
GO:0019310 myo-inositol catabolic process The chemical reactions and pathways resulting in the breakdown of myo-inositol, 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. BP
GO:0019311 sorbose metabolic process The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. BP
GO:0019312 L-sorbose metabolic process The chemical reactions and pathways involving sorbose, the levorotatory isomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol. BP
GO:0019313 allose metabolic process The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. BP
GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any aldose with a chain of six carbon atoms in the molecule. BP
GO:0019319 hexose biosynthetic process The chemical reactions and pathways resulting in the formation of hexose, any aldose with a chain of six carbon atoms in the molecule. BP
GO:0007047 cell wall organization and biogenesis The assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. BP
GO:0007045 hemi-adherens junction assembly The formation of a hemi-adherens junction. Within proximal sheath cells, actin/myosin bundles are anchored to the plasma membrane at plaque-like structures termed hemi-adherens junctions, which in turn are closely associated with the gonadal basal lamina. It is proposed that hemi-adherens junctions function to anchor the myofilament apparatus within the basal plasma membrane of the sheath cell and to the exterior basal lamina. BP
GO:0007044 cell-substrate junction assembly The assembly of abundant stress fibers, which help maintain cell shapes and adhere cells to the substratum. BP
GO:0007043 intercellular junction assembly The aggregation and bonding together of a junction between cells. BP
GO:0007042 lysosomal lumen acidification Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. BP
GO:0007041 lysosomal transport The directed movement of substances into, out of or within a lysosome. BP
GO:0007040 lysosome organization and biogenesis The assembly and arrangement of lysosomes. BP
GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. BP
GO:0032618 interleukin-15 production The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032619 interleukin-16 production The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032612 interleukin-1 production The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032613 interleukin-10 production The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032610 interleukin-1 alpha production The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032611 interleukin-1 beta production The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032616 interleukin-13 production The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032617 interleukin-14 production The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032614 interleukin-11 production The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032615 interleukin-12 production The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0052100 intraspecies quorum sensing The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules. BP
GO:0052101 induction by symbiont of host resistance gene-dependent defense response The activation by an organism of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052102 positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway Any process by which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052103 induction by symbiont of induced systemic resistance in host Any process by which an organism activates induced systemic resistance in the host; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052104 induction by symbiont of systemic acquired resistance in host Any process by which an organism activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052105 induction by symbiont of defense-related host cell wall thickening Any process by which an organism activates, maintains or increases the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052106 quorum sensing during interaction with host The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052107 positive regulation by symbiont of defense-related host callose deposition Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052108 growth or development of symbiont during interaction with host The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052109 positive regulation by symbiont of defense-related host cell wall callose deposition Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0005267 potassium channel activity NA MF
GO:0005261 cation channel activity NA MF
GO:0005260 channel-conductance-controlling ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. MF
GO:0000088 mitotic prophase Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle. BP
GO:0005262 calcium channel activity NA MF
GO:0006608 snRNP protein import into nucleus The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0006609 mRNA-binding (hnRNP) protein import into nucleus NA BP
GO:0006602 creatinine catabolic process The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. BP
GO:0006603 phosphocreatine metabolic process The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle. BP
GO:0006600 creatine metabolic process The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. BP
GO:0006601 creatine biosynthetic process The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. BP
GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. BP
GO:0006607 NLS-bearing substrate import into nucleus The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. BP
GO:0006604 phosphoarginine metabolic process The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates. BP
GO:0000083 G1/S-specific transcription in mitotic cell cycle Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle. BP
GO:0005550 pheromone binding Interacting selectively with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. MF
GO:0000738 DNA catabolic process, exonucleolytic The hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. BP
GO:0000739 DNA strand annealing activity Facilitates the base-pairing of complementary single-stranded DNA. MF
GO:0000734 gene conversion at mating-type locus, DNA repair synthesis Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus. BP
GO:0000735 removal of nonhomologous ends The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. BP
GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. BP
GO:0000737 DNA catabolic process, endonucleolytic The hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. BP
GO:0000730 DNA recombinase assembly The aggregation and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA. BP
GO:0000731 DNA synthesis during DNA repair Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template. BP
GO:0000732 strand displacement The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. BP
GO:0000733 DNA strand renaturation The identification and annealing of complementary base pairs in single-strand DNA. BP
GO:0004608 phosphatidylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine. MF
GO:0004609 phosphatidylserine decarboxylase activity Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2. MF
GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. MF
GO:0004605 phosphatidate cytidylyltransferase activity Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. MF
GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. MF
GO:0004601 peroxidase activity Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. MF
GO:0004602 glutathione peroxidase activity Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. MF
GO:0004603 phenylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. MF
GO:0018168 protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine. BP
GO:0018169 ribosomal S6-glutamic acid ligase activity NA MF
GO:0018164 DNA-protein covalent cross-linking via peptidyl-threonine The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine. BP
GO:0018165 peptidyl-tyrosine uridylylation The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase. BP
GO:0018166 C-terminal protein-tyrosinylation The ATP-dependent posttranslational addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase. BP
GO:0018167 protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine The linkage of the chromophore phycoerythrobilin to phycoerythrin. BP
GO:0018160 peptidyl-pyrromethane cofactor linkage The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. BP
GO:0018161 dipyrrin biosynthetic process The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group. BP
GO:0018162 peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine. BP
GO:0018163 DNA-protein covalent cross-linking via the 5'-end to peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine. BP
GO:0051259 protein oligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. BP
GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. BP
GO:0051251 positive regulation of lymphocyte activation Any process that activates or increases the frequency, rate or extent of lymphocyte activation. BP
GO:0051250 negative regulation of lymphocyte activation Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte activation. BP
GO:0051253 negative regulation of RNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. BP
GO:0051252 regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. BP
GO:0051255 spindle midzone assembly The cell cycle process whereby spindle midzone is formed. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. BP
GO:0051254 positive regulation of RNA metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. BP
GO:0051257 meiotic spindle midzone assembly The formation of the meiotic spindle midzone, the area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap. BP
GO:0051256 mitotic spindle midzone assembly The formation of the mitotic spindle midzone, the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap. BP
GO:0021748 dorsal cochlear nucleus development The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure. BP
GO:0021749 ventral cochlear nucleus development The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure. BP
GO:0021740 pontine nucleus development The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure. BP
GO:0021741 spinal trigeminal nucleus development The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure. BP
GO:0021742 abducens nucleus development The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure. BP
GO:0021743 hypoglossal nucleus development The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure. BP
GO:0021744 dorsal motor nucleus of vagus nerve development The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure. BP
GO:0021745 nucleus ambiguus development The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure. BP
GO:0021746 solitary nucleus development The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure. BP
GO:0021747 cochlear nucleus development The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure. BP
GO:0015691 cadmium ion transport The directed movement of cadmium (Cd) ions into, out of, within or between cells. BP
GO:0015690 aluminum ion transport The directed movement of aluminum (Al) ions into, out of, within or between cells. BP
GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells. BP
GO:0015692 lead ion transport The directed movement of lead (Pb) ions into, out of, within or between cells. BP
GO:0015695 organic cation transport The directed movement of organic cations into, out of, within or between cells. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. BP
GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells. BP
GO:0015697 quaternary ammonium group transport The directed movement into, out of, within or between cells of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. BP
GO:0015696 ammonium transport The directed movement of ammonium into, out of, within or between cells. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. BP
GO:0015699 antimonite transport The directed movement of antimonite into, out of, within or between cells. BP
GO:0015698 inorganic anion transport The directed movement of inorganic anions into, out of, within or between cells. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. BP
GO:0001920 negative regulation of receptor recycling Any process that stops, prevents, or reduces the rate of receptor recyling. BP
GO:0001921 positive regulation of receptor recycling Any process that activates or increases the frequency, rate or extent of receptor recyling. BP
GO:0001926 positive regulation of B-1 B cell differentiation Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation. BP
GO:0001927 exocyst assembly The aggregation and bonding together of various polypeptides into the exocyst complex. BP
GO:0001924 regulation of B-1 B cell differentiation Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. BP
GO:0001925 negative regulation of B-1 B cell differentiation Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation. BP
GO:0046350 galactosaminoglycan metabolic process The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose. BP
GO:0046351 disaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units. BP
GO:0046352 disaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units. BP
GO:0046353 aminoglycoside N3'-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3'-acetyl-2-deoxystreptamine antibiotic. MF
GO:0046354 mannan biosynthetic process The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. BP
GO:0046355 mannan catabolic process The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. BP
GO:0046356 acetyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. BP
GO:0046357 galactarate biosynthetic process The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid. BP
GO:0046358 butyrate biosynthetic process The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid. BP
GO:0046359 butyrate catabolic process The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid. BP
GO:0016348 leg joint morphogenesis (sensu Endopterygota) The process by which the anatomical structures of leg joint are generated and organized. Morphogenesis pertains to the creation of form. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0030429 kynureninase activity Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. MF
GO:0030428 cell septum A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. CC
GO:0030423 RNA interference, targeting of mRNA for destruction The process by which small interfering RNAs target cognate mRNA molecules for degradation. BP
GO:0030422 RNA interference, production of siRNA Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. BP
GO:0030421 defecation The expulsion of feces from the rectum. BP
GO:0030420 establishment of competence for transformation The process by which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation. BP
GO:0030427 site of polarized growth Any part of a cell where non-isotropic growth takes place. CC
GO:0030426 growth cone The migrating motile tip of a growing nerve cell axon or dendrite. CC
GO:0030425 dendrite A branching protoplasmic process of a neuron that receive and integrate signals coming from axons of other neurons, and convey the resulting signal to the body of the cell. CC
GO:0030424 axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. CC
GO:0009066 aspartate family amino acid metabolic process The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. BP
GO:0045199 maintenance of epithelial cell polarity The maintenance of the apicobasal polarity of an epithelial cell. BP
GO:0045198 establishment of epithelial cell polarity The specification and formation of the apicobasal polarity of an epithelial cell. BP
GO:0045193 acetylated low-density lipoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins. BP
GO:0045192 low-density lipoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats. BP
GO:0045191 regulation of isotype switching Any process that modulates the frequency, rate or extent of isotype switching. BP
GO:0045190 isotype switching The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. BP
GO:0045197 establishment and/or maintenance of epithelial cell polarity The specification, formation and maintenance of the apicobasal polarity of an epithelial cell. BP
GO:0045196 establishment and/or maintenance of neuroblast polarity The specification, formation and maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. BP
GO:0045194 oxidized low-density lipoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins. BP
GO:0047908 fusarinine-C ornithinesterase activity Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol. MF
GO:0047909 galactolipid O-acyltransferase activity Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol. MF
GO:0047906 fucosterol-epoxide lyase activity Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = desmosterol + acetaldehyde. MF
GO:0047907 furylfuramide isomerase activity Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide. MF
GO:0047904 fructose 5-dehydrogenase activity Catalysis of the reaction: D-fructose + acceptor = 5-dehydro-D-fructose + reduced acceptor. MF
GO:0047905 fructose-6-phosphate phosphoketolase activity Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O. MF
GO:0047902 formylaspartate deformylase activity Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate. MF
GO:0047903 fructose 5-dehydrogenase (NADP+) activity Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH. MF
GO:0047900 formate kinase activity Catalysis of the reaction: ATP + formate = ADP + formyl phosphate. MF
GO:0047901 formyl-CoA hydrolase activity Catalysis of the reaction: formyl-CoA + H2O = CoA + formate. MF
GO:0031482 myosin XII complex A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil. CC
GO:0031483 myosin XIII complex A myosin complex containing one or more class XIII myosin heavy chains and associated light chains. CC
GO:0031480 myosin X complex A myosin complex containing one or more class X myosin heavy chains and associated light chains. CC
GO:0031481 myosin XI complex A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions. CC
GO:0031486 myosin XVI complex A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat. CC
GO:0031487 myosin XVII complex A myosin complex containing one or more class XVII myosin heavy chains and associated light chains. CC
GO:0031484 myosin XIV complex A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails. CC
GO:0031485 myosin XV complex A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII. CC
GO:0031488 myosin XVIII complex A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain. CC
GO:0031489 myosin V binding Interacting selectively with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. MF
GO:0009386 translational attenuation Translational attentuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation. BP
GO:0009384 N-acylmannosamine kinase activity Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. MF
GO:0009385 N-acylmannosamine-6-phosphate 2-epimerase activity Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate. MF
GO:0009382 imidazoleglycerol-phosphate synthase complex Complex that possesses imidazoleglycerol-phosphate synthase activity. CC
GO:0009383 rRNA (cytosine-C5-967)-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine, at position 967 in the Escherichia coli small subunit ribosomal RNA or the equivalent position in the small subunit rRNA of other species. MF
GO:0009380 excinuclease ABC complex NA CC
GO:0009381 excinuclease ABC activity NA MF
GO:0009389 dimethyl sulfoxide reductase activity Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O. MF
GO:0005983 starch catabolic process The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants. BP
GO:0009658 chloroplast organization and biogenesis The assembly and arrangement of the chloroplast. BP
GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. BP
GO:0009650 UV protection The processes by which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. BP
GO:0009651 response to salt stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. BP
GO:0009652 thigmotropism The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it. BP
GO:0044243 organismal catabolic process The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. BP
GO:0009654 oxygen evolving complex NA CC
GO:0009655 PSII associated light-harvesting complex II, core complex The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center. CC
GO:0009656 PSII associated light-harvesting complex II, peripheral complex Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light. CC
GO:0009657 plastid organization and biogenesis The assembly and arrangement of a plastid. BP
GO:0008389 coumarin 7-hydroxylase activity Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. MF
GO:0008388 testosterone 15-alpha-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O. MF
GO:0008385 IkappaB kinase complex A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role. CC
GO:0008384 IkappaB kinase activity Catalysis of the phosphorylation of IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role. MF
GO:0008387 steroid 7-alpha-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O. MF
GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. MF
GO:0008381 mechanically-gated ion channel activity NA MF
GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. BP
GO:0008383 manganese superoxide dismutase activity Catalysis of the reaction: 2 peroxide radical + 2 H+ = O2 + H2O2. MF
GO:0008382 iron superoxide dismutase activity Catalysis of the reaction: 2 peroxide radical + 2 H+ = O2 + H2O2. MF
GO:0008528 peptide receptor activity, G-protein coupled NA MF
GO:0008521 acetyl-CoA transporter activity Enables the directed movement of acetyl-CoA into, out of, within or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. MF
GO:0008520 L-ascorbate:sodium symporter activity Catalysis of the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in). MF
GO:0008523 sodium-dependent multivitamin transporter activity Catalysis of the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. MF
GO:0008525 phosphatidylcholine transporter activity Enables the directed movement of phosphatidylcholine into, out of, within or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. MF
GO:0008524 glucose 6-phosphate:phosphate antiporter activity Catalysis of the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out). MF
GO:0008527 taste receptor activity Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. MF
GO:0008526 phosphatidylinositol transporter activity Enables the directed movement of phosphatidylinositol into, out of, within or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. MF
GO:0047296 homospermidine synthase activity Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine. MF
GO:0047297 asparagine-oxo-acid transaminase activity Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate. MF
GO:0047294 phosphoglycerol geranylgeranyltransferase activity Catalysis of the reaction: sn-glyceryl phosphate + geranylgeranyl-PP = sn-3-O-(geranylgeranyl)glyceryl 1-phosphate + diphosphate. MF
GO:0047295 geranylgeranylglycerol-phosphate geranylgeranyltransferase activity Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + geranylgeranyl-PP = 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate. MF
GO:0047292 trihydroxypterocarpan dimethylallyltransferase activity Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + pyrophosphate. MF
GO:0047293 4-hydroxybenzoate nonaprenyltransferase activity Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + pyrophosphate. MF
GO:0047290 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity Catalysis of the reaction: alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(alpha-N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R + CMP. MF
GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3. MF
GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity Catalysis of the reaction: 2-oxoglutarate + (S)-3-amino-2-methylpropanoate = L-glutamate + methylmalonate-semialdehyde. MF
GO:0047299 tryptophan-phenylpyruvate transaminase activity Catalysis of the reaction: phenylpyruvate + L-tryptophan = L-phenylalanine + indolepyruvate. MF
GO:0045676 regulation of R7 differentiation Any process that modulates the frequency, rate or extent of R7 differentiation. BP
GO:0045677 negative regulation of R7 differentiation Any process that stops, prevents or reduces the frequency, rate or extent of R7 differentiation. BP
GO:0045674 negative regulation of photoreceptor differentiation (sensu Endopterygota) Any process that stops, prevents or reduces the frequency, rate or extent of photoreceptor differentiation. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045675 positive regulation of photoreceptor differentiation (sensu Endopterygota) Any process that activates or increases the frequency, rate or extent of photoreceptor differentiation. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045672 positive regulation of osteoclast differentiation Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. BP
GO:0045673 regulation of photoreceptor differentiation (sensu Endopterygota) Any process that modulates the frequency, rate or extent of photoreceptor differentiation. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0045670 regulation of osteoclast differentiation Any process that modulates the frequency, rate or extent of osteoclast differentiation. BP
GO:0045671 negative regulation of osteoclast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast differentiation. BP
GO:0045678 positive regulation of R7 differentiation Any process that activates or increases the frequency, rate or extent of R7 differentiation. BP
GO:0045679 regulation of R8 differentiation Any process that modulates the frequency, rate or extent of R8 differentiation. BP
GO:0047128 1,2-dehydroreticulinium reductase (NADPH) activity Catalysis of the reaction: NADPH + 1,2-dehydroreticulinium = NADP+ + R-reticuline. MF
GO:0047129 opine dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate = NADH + pyruvate + L-2-aminopentanoic acid. MF
GO:0047120 (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity Catalysis of the reaction: NAD+ + (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate = NADH + CO2 + protocatechuate. MF
GO:0047121 isoquinoline 1-oxidoreductase activity Catalysis of the reaction: H2O + acceptor + isoquinoline = donor-H2 + isoquinolin-12H-one. MF
GO:0047122 quinaldate 4-oxidoreductase activity Catalysis of the reaction: H2O + acceptor + quinaldate = donor-H2 + kynurenate. MF
GO:0047123 quinoline-4-carboxylate 2-oxidoreductase activity Catalysis of the reaction: H2O + acceptor + quinoline-4-carboxylate = quinolin-2-ol + donor-H2. MF
GO:0047124 L-erythro-3,5-diaminohexanoate dehydrogenase activity Catalysis of the reaction: NAD+ + H2O + (3S,5S)-3,5-diaminohexanoate = NADH + NH3 + (S)-5-amino-3-oxohexanoate. MF
GO:0047125 delta1-piperideine-2-carboxylate reductase activity Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta(1)-piperideine-2-carboxylate. MF
GO:0047126 N5-(carboxyethyl)ornithine synthase activity Catalysis of the reaction: H2O + NADP+ + N5-(L-1-carboxyethyl)-L-ornithine = NADPH + pyruvate + L-ornithine. MF
GO:0047127 thiomorpholine-carboxylate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate. MF
GO:0030852 regulation of granulocyte differentiation Any process that modulates the frequency, rate or extent of granulocyte differentiation. BP
GO:0030853 negative regulation of granulocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of granulocyte differentiation. BP
GO:0030850 prostate gland development The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. BP
GO:0030851 granulocyte differentiation The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. BP
GO:0030856 regulation of epithelial cell differentiation Any process that modulates the frequency, rate or extent of epithelial cell differentiation. BP
GO:0030857 negative regulation of epithelial cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation. BP
GO:0030854 positive regulation of granulocyte differentiation Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. BP
GO:0030855 epithelial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. BP
GO:0030858 positive regulation of epithelial cell differentiation Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. BP
GO:0030859 polarized epithelial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. BP
GO:0050832 defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. BP
GO:0050833 pyruvate transporter activity Enables the directed movement of pyruvate, 2-oxopropanoate, into, out of, within or between cells. MF
GO:0050830 defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. BP
GO:0050831 male-specific defense response to bacterium A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism. BP
GO:0050836 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide. BP
GO:0050837 peptide cross-linking via L-cysteinyl-L-selenocysteine The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P. BP
GO:0050834 molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. BP
GO:0050835 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. BP
GO:0050838 peptidyl-5-hydroxy-L-lysine tri-methylation The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. BP
GO:0050839 cell adhesion molecule binding Interacting selectively with a cell adhesion molecule. MF
GO:0031815 P2Y5 nucleotide receptor binding Interacting selectively with a P2Y5 nucleotide receptor. MF
GO:0031814 P2Y4 nucleotide receptor binding Interacting selectively with a P2Y4 nucleotide receptor. MF
GO:0031817 P2Y8 nucleotide receptor binding Interacting selectively with a P2Y8 nucleotide receptor. MF
GO:0031816 P2Y6 nucleotide receptor binding Interacting selectively with a P2Y6 nucleotide receptor. MF
GO:0031811 metabotropic nucleotide receptor binding Interacting selectively with a metabotropic nucleotide receptor. MF
GO:0031810 H4 histamine receptor binding Interacting selectively with a H4 histamine receptor. MF
GO:0031813 P2Y2 nucleotide receptor binding Interacting selectively with a P2Y2 nucleotide receptor. MF
GO:0031812 P2Y1 nucleotide receptor binding Interacting selectively with a P2Y1 nucleotide receptor. MF
GO:0031819 P2Y10 nucleotide receptor binding Interacting selectively with a P2Y10 nucleotide receptor. MF
GO:0031818 P2Y9 nucleotide receptor binding Interacting selectively with a P2Y9 nucleotide receptor. MF
GO:0046659 digestive hormone activity A hormone that takes part in the digestion process. MF
GO:0046658 anchored to plasma membrane Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane. CC
GO:0050786 RAGE receptor binding Interacting selectively with the RAGE receptor, the receptor for advanced glycation end-products. MF
GO:0050787 detoxification of mercury ion The processes that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0]). BP
GO:0050780 dopamine receptor binding Interacting selectively with a dopamine receptor. MF
GO:0050781 ortho-trichlorophenol reductive dehalogenase activity Catalysis of the reaction: 2,4,6-trichlorophenol +2 H+ + 2 e- = 2,4-dichlorophenol + HCl. MF
GO:0050782 galactose uniporter activity Catalysis of the reaction: galactose (out) = galactose(in). MF
GO:0050783 cocaine metabolic process The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic. BP
GO:0046651 lymphocyte proliferation The rapid expansion of a lymphocyte population by cell division. BP
GO:0046653 tetrahydrofolate metabolic process The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin moiety. BP
GO:0046655 folic acid metabolic process The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. BP
GO:0046654 tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin moiety. BP
GO:0046657 folic acid catabolic process The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid. BP
GO:0046656 folic acid biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. BP
GO:0005719 nuclear euchromatin The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. CC
GO:0005715 late recombination nodule An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I. CC
GO:0005714 early recombination nodule An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I. CC
GO:0005713 recombination nodule An electron dense structure that is associated with meiotic chromosomes. CC
GO:0005712 chiasma A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over. CC
GO:0007626 locomotory behavior The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. BP
GO:0007625 grooming behavior The specific actions or reactions of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. BP
GO:0007624 ultradian rhythm The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours. BP
GO:0007623 circadian rhythm The biological processes in an organism that recur with a regularity of approximately 24 hours. BP
GO:0007622 rhythmic behavior The specific actions or reactions of an organism that recur with measured regularity. BP
GO:0007621 negative regulation of female receptivity Any process that stops, prevents or reduces the receptiveness of a female to male advances. BP
GO:0007620 copulation The act of sexual union between male and female, involving the transfer of sperm from male to female. BP
GO:0007629 flight behavior The actions or reactions of an individual relating to the movement of that organism through the air. BP
GO:0007628 adult walking behavior The actions or reactions of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. BP
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response. BP
GO:0002290 gamma-delta T cell activation during immune response The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. BP
GO:0002293 alpha-beta T cell differentiation during immune response The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. BP
GO:0002292 T cell differentiation during immune response The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. BP
GO:0002295 T-helper cell lineage commitment The process whereby an CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes. BP
GO:0002294 CD4-positive, alpha-beta T cell differentiation during immune response The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. BP
GO:0002297 T-helper 2 cell lineage commitment The process whereby an CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy. BP
GO:0002296 T-helper 1 cell lineage commitment The process whereby an CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis. BP
GO:0002299 alpha-beta intraepithelial T cell differentiation The process whereby a relatively unspecialized hemopoietic stem cell acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. BP
GO:0002298 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an CD4-positive, CD25-positive, alpha-beta regulatory T cell during an immune response. BP
GO:0048389 intermediate mesoderm development The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. BP
GO:0048388 endosomal lumen acidification Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion. BP
GO:0048381 lateral mesoderm structural organization The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048380 negative regulation of lateral mesodermal cell fate specification Any process that stops, prevents or reduces the frequency, rate or extent of lateral mesoderm cell fate specification. BP
GO:0048383 mesectoderm development The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues. BP
GO:0048382 mesendoderm development The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues. BP
GO:0048385 regulation of retinoic acid receptor signaling pathway Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. BP
GO:0048384 retinoic acid receptor signaling pathway The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. BP
GO:0048387 negative regulation of retinoic acid receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. BP
GO:0048386 positive regulation of retinoic acid receptor signaling pathway Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity. BP
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. MF
GO:0004446 multiple inositol-polyphosphate phosphatase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate. MF
GO:0004447 iodide peroxidase activity Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O. MF
GO:0004445 inositol-polyphosphate 5-phosphatase activity Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. MF
GO:0004448 isocitrate dehydrogenase activity Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor. MF
GO:0004449 isocitrate dehydrogenase (NAD+) activity Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. MF
GO:0018762 aliphatic nitrilase activity Catalysis of the reaction: R-CN + H2O = R-COOH + NH3. MF
GO:0018763 hydroxydechloroatrazine ethylaminohydrolase activity Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine. MF
GO:0018760 thiocyanate hydrolase activity Catalysis of the reaction: thiocyanate + H2O = NH3 + carbonyl sulfide. MF
GO:0018761 bromoxynil nitrilase activity Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxy-benzoate + NH3. Involved in the bacterial degradation of the herbicide bromoxynil. MF
GO:0018766 dihydrophloroglucinol hydrolase activity Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate. MF
GO:0018767 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate. MF
GO:0018764 N-isopropylammelide isopropylaminohydrolase activity Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine. MF
GO:0018765 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate. MF
GO:0018768 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoat + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate. MF
GO:0018769 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate. MF
GO:0006974 response to DNA damage stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. BP
GO:0006975 DNA damage induced protein phosphorylation The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage. BP
GO:0048031 trisaccharide binding Interacting selectively with any trisaccharide. Trisaccharides are sugars composed of three monosaccharide units. MF
GO:0048030 disaccharide binding Interacting selectively with any disaccharide. Disaccharides are sugars composed of two monosaccharide units. MF
GO:0048037 cofactor binding Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. MF
GO:0006971 hypotonic response A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. BP
GO:0006972 hyperosmotic response A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. BP
GO:0048034 heme o biosynthetic process The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. BP
GO:0048039 ubiquinone binding Interacting selectively with ubiquinone, a quinone derivative with a tail of isoprene units. MF
GO:0048038 quinone binding Interacting selectively with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. MF
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. BP
GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. BP
GO:0004194 pepsin A activity Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin. MF
GO:0004195 renin activity Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I. MF
GO:0004196 saccharopepsin activity Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24. MF
GO:0004197 cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. MF
GO:0004190 aspartic-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. MF
GO:0004191 barrierpepsin activity Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor. MF
GO:0004192 cathepsin D activity Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin. MF
GO:0004193 cathepsin E activity Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity. MF
GO:0004198 calpain activity Catalysis of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue. MF
GO:0021508 floor plate formation The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage. BP
GO:0021509 roof plate formation The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells. BP
GO:0021506 anterior neuropore closure The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete. BP
GO:0021507 posterior neuropore closure The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete. BP
GO:0021504 neural fold hinge point formation The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube. BP
GO:0021505 neural fold folding The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds. BP
GO:0021502 neural fold elevation formation The process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm. BP
GO:0021503 neural fold bending The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse. BP
GO:0021501 prechordal plate formation The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. BP
GO:0050003 deoxycytidylate C-methyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = deoxy-5-methylcytidylate + 7,8-dihydrofolate. MF
GO:0050002 D-proline reductase (dithiol) activity Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline. MF
GO:0050001 D-glutaminase activity Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate. MF
GO:0050000 chromosome localization The processes by which a chromosome is transported to, or maintained in, a specific location. BP
GO:0050007 isonocardicin synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + nocardicin E = 5'-methylthioadenosine + isonocardicin A. MF
GO:0050006 isomaltulose synthase activity Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose. MF
GO:0050005 isohexenylglutaconyl-CoA hydratase activity Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + H2O. MF
GO:0050004 isoflavone 7-O-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside. MF
GO:0050009 isopropanol dehydrogenase (NADP+) activity Catalysis of the reaction: propan-2-ol + NADP+ = acetone + NADPH. MF
GO:0050008 isopiperitenone delta-isomerase activity Catalysis of the reaction: isopiperitenone = piperitenone. MF
GO:0002909 negative regulation of peripheral B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion. BP
GO:0002908 regulation of peripheral B cell deletion Any process that modulates the frequency, rate, or extent of peripheral B cell deletion. BP
GO:0002901 mature B cell apoptosis The process of apoptosis in mature B cells. BP
GO:0002900 positive regulation of central B cell deletion Any process that activates or increases the frequency, rate, or extent of central B cell deletion. BP
GO:0002903 negative regulation of B cell apoptosis Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptosis. BP
GO:0002902 regulation of B cell apoptosis Any process that modulates the frequency, rate, or extent of B cell apoptosis. BP
GO:0002905 regulation of mature B cell apoptosis Any process that modulates the frequency, rate, or extent of mature B cell apoptosis. BP
GO:0002904 positive regulation of B cell apoptosis Any process that activates or increases the frequency, rate, or extent of B cell apoptosis. BP
GO:0002907 positive regulation of mature B cell apoptosis Any process that activates or increases the frequency, rate, or extent of mature B cell apoptosis. BP
GO:0002906 negative regulation of mature B cell apoptosis Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptosis. BP
GO:0007362 terminal region determination Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products. BP
GO:0007363 positive regulation of terminal gap gene transcription The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes. BP
GO:0007360 positive regulation of posterior gap gene transcription The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene. BP
GO:0007361 establishment of posterior gap gene boundaries Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps. BP
GO:0007366 periodic partitioning by pair rule gene Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities. BP
GO:0007367 segment polarity determination Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products. BP
GO:0007364 establishment of terminal gap gene boundary Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes. BP
GO:0007365 periodic partitioning The regionalization process that divides the spatial regions of an embryo into serially repeated regions. BP
GO:0007368 determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. BP
GO:0007369 gastrulation A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. BP
GO:0051660 establishment of centrosome localization The directed movement of the centrosome to a specific location. BP
GO:0051661 maintenance of centrosome localization The processes by which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051662 oocyte nucleus localization during oocyte axis determination (sensu Insecta) The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the axes of the oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0051663 oocyte nucleus localization during oocyte axis determination The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the axes of the oocyte. BP
GO:0051664 nuclear pore localization The processes by which nuclear pores are transported to, or maintained in, a specific location. BP
GO:0051665 lipid raft localization The processes by which lipid rafts are transported to, or maintained in, a specific location. Lipid rafts are tightly-packed gel-like membrane microdomains enriched in sphingolipids and cholesterol. BP
GO:0051666 actin cortical patch localization The processes by which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells. BP
GO:0051667 establishment of plastid localization The directed movement of a plastid to a specific location in the cell. BP
GO:0051668 localization within membrane The processes by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. BP
GO:0051669 fructan beta-fructosidase activity Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans. MF
GO:0052311 negative regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052310 modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052313 modulation of nutrient release from other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052312 modulation of transcription in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052315 phytoalexin biosynthesis The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response. BP
GO:0052314 phytoalexin metabolism The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response. BP
GO:0052317 camalexin metabolism The chemical reactions and pathways involving camalexin, an indole phytoalexin. BP
GO:0052316 phytoalexin catabolism The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response. BP
GO:0052319 regulation of phytoalexin biosynthesis Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. BP
GO:0052318 regulation of phytoalexin metabolism Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response. BP
GO:0006105 succinate metabolic process The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle. BP
GO:0006104 succinyl-CoA metabolic process The chemical reactions and pathways involving succinyl-CoA, a compound composed of the univalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A. BP
GO:0006107 oxaloacetate metabolic process The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. BP
GO:0006106 fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. BP
GO:0006101 citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle. BP
GO:0006100 tricarboxylic acid cycle intermediate metabolic process The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle. BP
GO:0006103 2-oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. BP
GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. BP
GO:0006109 regulation of carbohydrate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. BP
GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. BP
GO:0005458 GDP-mannose transporter activity Enables the directed movement of GDP-mannose into, out of, within or between cells. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate. MF
GO:0005459 UDP-galactose transporter activity Enables the directed movement of UDP-galactose into, out of, within or between cells. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. MF
GO:0005452 inorganic anion exchanger activity NA MF
GO:0005451 monovalent cation:proton antiporter activity Catalysis of the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). MF
GO:0005456 CMP-sialic acid transporter activity Enables the directed movement of CMP-sialic acid into, out of, within or between cells. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate. MF
GO:0005457 GDP-fucose transporter activity Enables the directed movement of GDP-fucose into, out of, within or between cells. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. MF
GO:0016999 antibiotic metabolic process The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. BP
GO:0016998 cell wall catabolic process The chemical reactions and pathways resulting in the breakdown of a cell wall. BP
GO:0016997 alpha-sialidase activity Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. MF
GO:0016996 endo-alpha-sialidase activity Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids. MF
GO:0016995 cholesterol oxidase activity Catalysis of the reaction: cholesterol + O2 = cholest-4-en-3-one + H2O2. MF
GO:0016994 precorrin-6A reductase activity Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+. MF
GO:0016993 precorrin-8X methylmutase activity Catalysis of the reaction: precorrin-8X = hydrogenobyrinate. MF
GO:0016992 lipoate synthase activity NA MF
GO:0016991 gentamicin 3'-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + gentamicin C = CoA + N3'-acetylgentamicin C. MF
GO:0016990 arginine deiminase activity Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3. MF
GO:0043145 snoRNA 3' end cleavage The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional. BP
GO:0015718 monocarboxylic acid transport The directed movement of monocarboxylic acids into, out of, within or between cells. BP
GO:0015719 allantoate transport The directed movement of allantoate into, out of, within or between cells. BP
GO:0047728 carnitine 3-dehydrogenase activity Catalysis of the reaction: NAD+ + L-carnitine = NADH + 3-dehydrocarnitine. MF
GO:0047729 carnitine decarboxylase activity Catalysis of the reaction: carnitine = 2-methylcholine + CO2. MF
GO:0015714 phosphoenolpyruvate transport The directed movement of phosphoenolpyruvate into, out of, within or between cells. BP
GO:0015715 nucleotide-sulfate transport NA BP
GO:0015716 phosphonate transport The directed movement of phosphonates into, out of, within or between cells. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). BP
GO:0015717 triose phosphate transport The directed movement of triose phosphate into, out of, within or between cells. BP
GO:0015710 tellurite transport The directed movement of tellurite into, out of, within or between cells. BP
GO:0015711 organic anion transport The directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. BP
GO:0015712 hexose phosphate transport The directed movement of hexose phosphate into, out of, within or between cells. BP
GO:0015713 phosphoglycerate transport The directed movement of phosphoglycerate into, out of, within or between cells. BP
GO:0043438 acetoacetic acid metabolic process The chemical reactions and pathways involving acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. BP
GO:0043439 butanoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of any butanoic acid, 4-carbon saturated monocarboxylic acids. BP
GO:0043436 oxoacid metabolic process The chemical reactions and pathways involving any oxoacid, acids containing a ketone group (-CO-) in addition to the acid group(s). BP
GO:0043437 butanoic acid metabolic process The chemical reactions and pathways involving any butanoic acid, 4-carbon saturated monocarboxylic acids. BP
GO:0043434 response to peptide hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. BP
GO:0043435 response to corticotropin-releasing hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. BP
GO:0043433 negative regulation of transcription factor activity Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. BP
GO:0043430 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. MF
GO:0043431 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine. MF
GO:0043380 regulation of memory T cell differentiation Any process that modulates the frequency, rate, or extent of memory T cell differentiation. BP
GO:0043381 negative regulation of memory T cell differentiation Any process that stops, prevents, or reduces the rate of memory T cell differentiation. BP
GO:0043382 positive regulation of memory T cell differentiation Any process that activates or increases the frequency, rate or extent of memory T cell differentiation. BP
GO:0043383 negative T cell selection The process of elimination of immature T cells which react strongly with self-antigens. BP
GO:0043384 pre-T cell receptor complex A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins. CC
GO:0043385 mycotoxin metabolic process The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus. BP
GO:0043386 mycotoxin biosynthetic process The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus. BP
GO:0043387 mycotoxin catabolic process The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus. BP
GO:0043388 positive regulation of DNA binding Any process that activates or increases the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid. BP
GO:0043389 aflatoxin B metabolic process The chemical reactions and pathways involving aflatoxins with a B designation. Distinguished from other aflatoxins by their exhibition of blue fluorescence under UV-light. BP
GO:0046099 guanine biosynthetic process The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. BP
GO:0046098 guanine metabolic process The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. BP
GO:0046097 deoxyuridine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. BP
GO:0046096 deoxyuridine metabolic process The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA. BP
GO:0046095 deoxyinosine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside. BP
GO:0046094 deoxyinosine metabolic process The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside. BP
GO:0046093 deoxycytidine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. BP
GO:0046092 deoxycytidine metabolic process The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. BP
GO:0046091 deoxyadenosine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. BP
GO:0046090 deoxyadenosine metabolic process The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA. BP
GO:0020004 parasitophorous vacuolar space Space between a parasite plasma membrane and the parasitophorous vacuolar membrane. CC
GO:0020005 parasitophorous vacuolar membrane The lipid bilayer surrounding a parasitophorous vacuole. CC
GO:0020006 parasitophorous vacuolar membrane network Tubular network of extensions from the parasitophorous vacuolar membrane that protrude into the host cytoplasm. CC
GO:0020007 apical complex Protruding complex at the anterior end of some life cycle stages of all apicomplexan parasites, involved in both the attachment and penetration of the host cell by the parasite. CC
GO:0020002 host cell plasma membrane The plasma membrane surrounding a host cell. CC
GO:0020003 parasitophorous vacuole Vacuole within a host cell in which a parasite resides. CC
GO:0020008 rhoptry The tubular or sacular organelle of an apical complex. CC
GO:0020009 microneme Elongated tubular organelle arranged longitudinally in the apical complex of an apicomplexan parasite. CC
GO:0047711 blasticidin-S deaminase activity Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3. MF
GO:0030386 ferredoxin:thioredoxin reductase complex Complex that possesses ferredoxin:thioredoxin reductase activity. CC
GO:0030387 fructosamine-3-kinase activity Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase. MF
GO:0030384 phosphoinositide metabolic process The chemical reactions and pathways involving phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. They are important constituents of cell membranes. BP
GO:0030385 ferredoxin:thioredoxin reductase activity Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide. MF
GO:0030382 sperm mitochondrion organization and biogenesis The assembly and arrangement of sperm mitochondria; the process by which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm. BP
GO:0030380 interleukin-17E receptor binding Interacting selectively with the interleukin-17E receptor. MF
GO:0030381 eggshell pattern formation (sensu Insecta) The regionalization process that gives rise to the pattern of cell differentiation in the eggshell. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030388 fructose 1,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. BP
GO:0030389 fructosamine metabolic process The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group. BP
GO:0047666 ammonia kinase activity Catalysis of the reaction: ATP + NH3 = ADP + phosphoramide. MF
GO:0047665 aminolevulinate transaminase activity Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine. MF
GO:0047664 aminoimidazolase activity Catalysis of the reaction: 4-aminoimidazole + H2O = unidentified product + NH3. MF
GO:0030658 transport vesicle membrane The lipid bilayer surrounding a transport vesicle. CC
GO:0030659 cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle. CC
GO:0047661 amino-acid racemase activity Catalysis of the reaction: an L-amino acid = a D-amino acid. MF
GO:0030650 peptide antibiotic metabolic process The chemical reactions and pathways involving peptides with antibiotic activity. BP
GO:0030651 peptide antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity. BP
GO:0030652 peptide antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity. BP
GO:0047660 amidinoaspartase activity Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea. MF
GO:0030654 beta-lactam antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. BP
GO:0030655 beta-lactam antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. BP
GO:0030656 regulation of vitamin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. BP
GO:0031389 Rad17 RFC-like complex A pentameric complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Saccharomyces the subunits are known as Rad17p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. CC
GO:0031388 organic acid phosphorylation The process of introducing one or more phosphoric groups into an organic acid. BP
GO:0031385 regulation of termination of mating projection growth Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi. BP
GO:0031384 regulation of initiation of mating projection growth Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi. BP
GO:0031387 MPF complex A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13p. The MPF complex phosphorylates and activates the anaphase promoting complex (APC). CC
GO:0031386 protein tag Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question. MF
GO:0031381 viral RNA-directed RNA polymerase complex A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus. CC
GO:0031380 nuclear RNA-directed RNA polymerase complex A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain. CC
GO:0031383 regulation of mating projection biogenesis Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi. BP
GO:0031382 mating projection biogenesis Formation of a projection by unicellular fungi in response to mating pheromone. BP
GO:0045016 mitochondrial magnesium ion transport The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein. BP
GO:0045017 glycerolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. BP
GO:0045014 negative regulation of transcription by glucose Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase. BP
GO:0045015 HDEL sequence binding Interacting selectively with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. MF
GO:0045013 negative regulation of transcription by carbon catabolites Any process involving carbon catabolites that stops, prevents or reduces the rate of transcription. Carbon catabolite repression is a mechanism of genetic regulation in bacteria in which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. BP
GO:0045010 actin nucleation The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. BP
GO:0045011 actin cable formation The assembly of the long bundles of actin filaments known as actin cables. BP
GO:0045018 retrograde transport, vacuole to Golgi The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment. BP
GO:0045019 negative regulation of nitric oxide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. BP
GO:0031529 ruffle organization and biogenesis The assembly and arrangement of a ruffle, a projection at the leading edge of a crawling cell. BP
GO:0031528 microvillus membrane The portion of the plasma membrane surrounding a microvillus. CC
GO:0031521 spitzenkorper Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments. CC
GO:0031520 plasma membrane of cell tip The portion of the plasma membrane surrounding the cell tip. CC
GO:0031523 Myb complex A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression. CC
GO:0031522 Sec complex (sensu Bacteria) A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0031525 menthol biosynthetic process The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol. BP
GO:0031524 menthol metabolic process The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol. BP
GO:0031527 filopodium membrane The portion of the plasma membrane surrounding a filopodium. CC
GO:0031526 brush border membrane The portion of the plasma membrane surrounding the brush border. CC
GO:0046848 hydroxyapatite binding Interacting selectively with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentine. MF
GO:0046849 bone remodeling The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. BP
GO:0046844 micropyle formation Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization. BP
GO:0046845 branched duct epithelial cell fate determination (sensu Insecta) Allocation of a set number of cells to each primary tracheal branch, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0046847 filopodium formation The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon. BP
GO:0046841 trisporic acid metabolic process The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota. BP
GO:0046842 trisporic acid biosynthetic process The chemical reactions and pathways resulting in the formation of trisporic acid. BP
GO:0046843 dorsal appendage formation Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration. BP
GO:0002321 natural killer cell progenitor differentiation The process whereby an unspecialized hemopoietic stem cell acquires the specialized features of a natural killer cell progenitor. BP
GO:0006349 imprinting Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. BP
GO:0006348 chromatin silencing at telomere Repression of transcription of telomeric DNA by the formation of heterochromatin. BP
GO:0006343 establishment of chromatin silencing The initial formation of transcriptionally silent heterochromatin. BP
GO:0006342 chromatin silencing Repression of transcription by conversion of large regions of DNA into an inaccessible state often called heterochromatin. BP
GO:0006346 methylation-dependent chromatin silencing Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. BP
GO:0006345 loss of chromatin silencing The process leading to expression of genes that are typically not expressed due to silencing by regulatory proteins. BP
GO:0006344 maintenance of chromatin silencing The maintenance of chromatin in a transciptionally silent heterochromatin state. BP
GO:0042568 insulin-like growth factor binary complex A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development. CC
GO:0042567 insulin-like growth factor ternary complex A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development. CC
GO:0042566 hydrogenosome A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation. CC
GO:0042565 RNA nuclear export complex A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore. CC
GO:0042564 NLS-dependent protein nuclear import complex A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore. CC
GO:0042563 importin alpha-subunit nuclear export complex A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore. CC
GO:0042562 hormone binding Interacting selectively with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. MF
GO:0042561 alpha-amyrin synthase activity Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into alpha-amyrin. MF
GO:0042560 pteridine and derivative catabolic process The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. BP
GO:0019934 cGMP-mediated signaling A series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response. BP
GO:0002539 prostaglandin production during acute inflammatory response The synthesis or release of any prostaglandin following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0000187 activation of MAPK activity The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK. BP
GO:0000186 activation of MAPKK activity The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK. BP
GO:0000185 activation of MAPKKK activity Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase. BP
GO:0000184 mRNA catabolic process, nonsense-mediated decay The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. BP
GO:0000183 chromatin silencing at rDNA Repression of transcription of ribosomal DNA by the formation of heterochromatin. BP
GO:0000182 rDNA binding Interacting selectively with DNA sequences encoding ribosomal RNA. MF
GO:0000189 nuclear translocation of MAPK The directed movement of a MAP kinase to the nucleus upon activation. BP
GO:0000188 inactivation of MAPK activity Any process that terminates the activity of the active enzyme MAP kinase. BP
GO:0004877 complement component C3b receptor activity Combining with the C3b product of the complement cascade to initiate a change in cell activity. MF
GO:0004876 complement component C3a receptor activity Combining with the C3a product of the complement cascade to initiate a change in cell activity. MF
GO:0004875 complement receptor activity Combining with any component or product of the complement cascade to initiate a change in cell activity. MF
GO:0004874 aryl hydrocarbon receptor activity Combining with an aryl hydrocarbon to initiate a change in cell activity. MF
GO:0004873 asialoglycoprotein receptor activity The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate moieties has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane. MF
GO:0004872 receptor activity Combining with an extracellular or intracellular messenger to initiate a change in cell activity. MF
GO:0004871 signal transducer activity Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. MF
GO:0004879 ligand-dependent nuclear receptor activity A ligand-dependent receptor found in the nucleus of the cell. MF
GO:0004878 complement component C5a receptor activity Combining with the C5a product of the complement cascade to initiate a change in cell activity. MF
GO:0050663 cytokine secretion The regulated release of cytokines from a cell or group of cells. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. BP
GO:0050662 coenzyme binding Interacting selectively with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. MF
GO:0050661 NADP binding Interacting selectively with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. MF
GO:0050660 FAD binding Interacting selectively with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. MF
GO:0050667 homocysteine metabolic process The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. BP
GO:0050666 regulation of homocysteine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. BP
GO:0050665 hydrogen peroxide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. BP
GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. MF
GO:0019938 peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions. BP
GO:0050669 negative regulation of homocysteine metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine. BP
GO:0050668 positive regulation of homocysteine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine. BP
GO:0019939 peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine The posttranslational modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically. BP
GO:0005690 snRNP U4atac Ribonucleoprotein complex containing small nuclear RNA U4atac; a component of the minor spliceosome complex. CC
GO:0005691 snRNP U6atac Ribonucleoprotein complex containing small nuclear RNA U6atac; a component of the minor spliceosome complex. CC
GO:0005692 snRNP U11 Ribonucleoprotein complex containing small nuclear RNA U11; a component of the minor spliceosome complex. CC
GO:0005693 snRNP U12 Ribonucleoprotein complex containing small nuclear RNA U12; a component of the minor spliceosome complex. CC
GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. CC
GO:0005697 telomerase holoenzyme complex Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. CC
GO:0002318 myeloid progenitor cell differentiation The process whereby an unspecialized hemopoietic stem cell acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. BP
GO:0002319 memory B cell differentiation The process whereby a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody. BP
GO:0002314 germinal center B cell differentiation The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). BP
GO:0002315 marginal zone B cell differentiation The process whereby a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). BP
GO:0002316 follicular B cell differentiation The process whereby a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region. BP
GO:0002317 plasma cell differentiation The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. BP
GO:0002310 alpha-beta T cell proliferation during immune response The rapid expansion of an alpha-beta T cell population by cell division during an immune response. BP
GO:0002311 gamma-delta T cell proliferation during immune response The rapid expansion of an gamma-delta T cell population by cell division during an immune response. BP
GO:0002312 B cell activation during immune response The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. BP
GO:0002313 mature B cell differentiation during immune response The process whereby a nave B cell acquires the specialized features of a mature or memory B cell during an immune response. BP
GO:0004253 gamma-renin activity Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide. MF
GO:0004252 serine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a reaction mechanism involving a serine residue (and a histidine residue) at the active center of the enzyme. MF
GO:0004251 X-Pro dipeptidase activity Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro. MF
GO:0004250 aminopeptidase I activity Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates. MF
GO:0051044 positive regulation of membrane protein ectodomain proteolysis Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. BP
GO:0051045 negative regulation of membrane protein ectodomain proteolysis Any process that stops, prevents or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. BP
GO:0051046 regulation of secretion Any process that modulates the frequency, rate or extent of the regulated release of a substance from a cell or group of cells. BP
GO:0051047 positive regulation of secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a substance from a cell or group of cells. BP
GO:0051048 negative regulation of secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a substance from a cell or group of cells. BP
GO:0051049 regulation of transport Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. BP
GO:0010120 camalexin biosynthetic process The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin. BP
GO:0009131 pyrimidine nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0010122 arginine catabolic process to alanine via ornithine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine. BP
GO:0010123 acetate catabolic process to butyrate, ethanol, acetone and butanol The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol. BP
GO:0010124 phenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylacetate. BP
GO:0010125 mycothiol biosynthetic process The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione. BP
GO:0010126 mycothiol metabolic process The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione. BP
GO:0010127 mycothiol-dependent detoxification The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell. BP
GO:0010128 benzoate catabolic process via CoA ligation The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway. BP
GO:0010129 anaerobic cyclohexane-1-carboxylate catabolic process The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen. BP
GO:0050221 prostaglandin-E2 9-reductase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. MF
GO:0018357 protein-phycourobilin linkage via phycourobilin-bis-L-cysteine The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine. BP
GO:0018356 protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine. BP
GO:0018355 protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine NA BP
GO:0018354 peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine NA BP
GO:0018353 protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine. BP
GO:0018352 protein-pyridoxal-5-phosphate linkage NA BP
GO:0018351 peptidyl-cysteine esterification NA BP
GO:0018350 protein amino acid esterification The addition of an ester group to a protein amino acid. BP
GO:0009135 purine nucleoside diphosphate metabolic process The chemical reactions and pathways involving purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0018359 protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine. BP
GO:0009134 nucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009137 purine nucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009136 purine nucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0001759 induction of an organ The close range interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. BP
GO:0001758 retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. MF
GO:0001755 neural crest cell migration The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. BP
GO:0001754 eye photoreceptor cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. BP
GO:0001757 somite specification The process by which individual somites establish identity during embryogenesis. BP
GO:0001756 somitogenesis The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. BP
GO:0001751 eye photoreceptor cell differentiation (sensu Endopterygota) The process whereby a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0001750 photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes. CC
GO:0001752 eye photoreceptor fate commitment (sensu Endopterygota) Cell commitment of the eye photoreceptors in the fly. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0015798 myo-inositol transport The directed movement of myo-inositol into, out of, within or between cells. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. BP
GO:0015799 propanediol transport The directed movement of propanediol into, out of, within or between cells. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. BP
GO:0016265 death A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. BP
GO:0046016 positive regulation of transcription by glucose Any process involving glucose that activates or increases the rate of transcription. BP
GO:0046015 regulation of transcription by glucose Any process involving glucose that modulates the frequency, rate or extent or transcription. BP
GO:0052533 positive regulation by symbiont of induced systemic resistance in host Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052532 positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052535 positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052537 positive regulation by symbiont of systemic acquired resistance in host Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052539 positive regulation by symbiont of defense-related host cell wall thickening Any process by which an organism activates, maintains or increases the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052538 positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0046012 positive regulation of oskar mRNA translation Any process that activates or increases the frequency, rate or extent of oskar mRNA translation. BP
GO:0016607 nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. CC
GO:0016606 Lands A class of nuclear body (Lands = LYSP100-associated nuclear domains); they are globular, electron-dense structures that may traffic between the nucleus and cytoplasm; they react against SP140 auto-antibodies. CC
GO:0016605 PML body A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. CC
GO:0016604 nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. CC
GO:0016603 glutaminyl-peptide cyclotransferase activity Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. MF
GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. CC
GO:0016601 Rac protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. BP
GO:0016600 flotillin complex A heteromeric complex of flotillin 1, flotillin 2, caveolin 1 and caveolin 2 within the caveolar membrane. CC
GO:0016262 protein N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. MF
GO:0016609 G-protein coupled serotonin receptor activity NA MF
GO:0016608 growth hormone-releasing hormone activity NA MF
GO:0019404 galactitol catabolic process The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. BP
GO:0019405 alditol catabolic process The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. BP
GO:0019406 hexitol biosynthetic process The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule. BP
GO:0019407 hexitol catabolic process The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule. BP
GO:0019400 alditol metabolic process The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. BP
GO:0019401 alditol biosynthetic process The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. BP
GO:0019402 galactitol metabolic process The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. BP
GO:0019403 galactitol biosynthetic process The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. BP
GO:0042822 pyridoxal phosphate metabolic process The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. BP
GO:0042823 pyridoxal phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. BP
GO:0042820 vitamin B6 catabolic process The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. BP
GO:0042821 pyridoxal biosynthetic process The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. BP
GO:0042826 histone deacetylase binding Interacting selectively with the enzyme histone deacetylase. MF
GO:0019409 aerobic respiration, using ammonium as electron donor NA BP
GO:0042824 MHC class I peptide loading complex A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. CC
GO:0042825 TAP complex A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum. CC
GO:0005070 SH3/SH2 adaptor activity Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). MF
GO:0005071 transmembrane receptor protein serine/threonine kinase signaling protein activity NA MF
GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity Activity of any of the molecules that transmit the signal from a TGFbeta receptor through the cytoplasm to the nucleus. MF
GO:0048863 stem cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. BP
GO:0048864 stem cell development The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. BP
GO:0048865 stem cell fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into a stem cell. BP
GO:0000402 crossed form four-way junction DNA binding Interacting selectively with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands. MF
GO:0000403 Y-form DNA binding Interacting selectively with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. MF
GO:0000400 four-way junction DNA binding Interacting selectively with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. MF
GO:0000401 open form four-way junction DNA binding Interacting selectively with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over. MF
GO:0000406 double-strand/single-strand DNA junction binding Interacting selectively with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA. MF
GO:0000407 pre-autophagosomal structure A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. CC
GO:0000404 loop DNA binding Interacting selectively with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. MF
GO:0000405 bubble DNA binding Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains an region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. MF
GO:0000408 EKC/KEOPS protein complex A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. CC
GO:0000409 regulation of transcription by galactose Any process involving galactose that modulates the frequency, rate or extent or transcription. BP
GO:0048868 pollen tube development The process whose specific outcome is the progression of a pollen tube over time, from its intial formation to a mature structure. BP
GO:0052298 modulation by organism of induced systemic resistance in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052299 modulation by organism of systemic acquired resistance in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052294 modulation by organism of cell-mediated immune response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052295 modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052296 modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction NA BP
GO:0052297 modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052290 induction by organism of defense-related cell wall thickening in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052291 positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052292 positive regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition by a second organism of callose in its cell walls, occurring as part of the defense response, where the two organisms are in a symbiotic interaction. BP
GO:0052293 modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0008770 [acyl-carrier-protein] phosphodiesterase activity Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein. MF
GO:0008771 [citrate (pro-3S)-lyase] ligase activity Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form). MF
GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate. MF
GO:0008773 [protein-PII] uridylyltransferase activity Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). MF
GO:0008774 acetaldehyde dehydrogenase (acetylating) activity Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+. MF
GO:0008775 acetate CoA-transferase activity Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. MF
GO:0008776 acetate kinase activity Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate. MF
GO:0008777 acetylornithine deacetylase activity Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine. MF
GO:0008778 acyl-CoA thioesterase II activity NA MF
GO:0008779 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. MF
GO:0046440 L-lysine metabolic process The chemical reactions and pathways involving L-lysine, the levorotatory isomer of (S)-2,6-diaminohexanoic acid. BP
GO:0046441 D-lysine metabolic process The chemical reactions and pathways involving D-lysine, the dextrorotatory isomer of (S)-2,6-diaminohexanoic acid. BP
GO:0046442 aerobactin metabolic process The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid. BP
GO:0046443 FAD metabolic process The chemical reactions and pathways involving FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. BP
GO:0046444 FMN metabolic process The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase. BP
GO:0046445 benzyl isoquinoline alkaloid metabolic process The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings. BP
GO:0046446 purine alkaloid metabolic process The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure. BP
GO:0046447 terpenoid indole alkaloid metabolic process The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate). BP
GO:0046448 tropane alkaloid metabolic process The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. BP
GO:0046449 creatinine metabolic process The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. BP
GO:0045931 positive regulation of progression through mitotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the mitotic cell cycle. BP
GO:0045930 negative regulation of progression through mitotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of progression through the mitotic cell cycle. BP
GO:0045933 positive regulation of muscle contraction Any process that activates or increases the frequency, rate or extent of muscle contraction. BP
GO:0045932 negative regulation of muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of muscle contraction. BP
GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. BP
GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. BP
GO:0045937 positive regulation of phosphate metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. BP
GO:0045936 negative regulation of phosphate metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. BP
GO:0045939 negative regulation of steroid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. BP
GO:0045938 positive regulation of circadian sleep/wake cycle, sleep Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. BP
GO:0043191 ATP-binding cassette (ABC) transporter complex (sensu Eukaryota) ATP-binding cassette (ABC) transporter complex (sensu Eukarya) A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0043190 ATP-binding cassette (ABC) transporter complex A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In bacteria and archaebacteria, ABC transporters also recruit substrate binding proteins to bind substrate external to the cell and deliver it to the transporter. CC
GO:0043193 positive regulation of gene-specific transcription Any process that activates or increases the frequency, rate or extent of the DNA-dependent transcription of a specific gene or genes. BP
GO:0043192 ATP-binding cassette (ABC) transporter complex (sensu Bacteria and Archaea) A complex for the transport of metabolites into and out of the cell, comprised of a permease domain integral to the plasma membrane, a membrane associated ATP-binding domain, and a periplasmic (in Gram-negative organims) or membrane anchored (in Gram-positive organisms) substrate-binding domain. The substrate-binding domain is not found in the efflux form. These domains can occur on one or more polypeptides. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0043195 terminal button Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. CC
GO:0043194 initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. CC
GO:0043197 dendritic spine Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity. CC
GO:0043196 varicosity Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. CC
GO:0043199 sulfate binding Interacting selectively with sulfate (SO42-), a negatively charged small molecule. MF
GO:0043198 dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. CC
GO:0048510 regulation of timing of transition from vegetative to reproductive phase The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs. BP
GO:0015721 bile acid transport The directed movement of bile acid into, out of, within or between cells. BP
GO:0048512 circadian behavior The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours. BP
GO:0048513 organ development Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. BP
GO:0048514 blood vessel morphogenesis The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood. BP
GO:0048515 spermatid differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a spermatid cell. BP
GO:0047752 cholestenone 5-beta-reductase activity Catalysis of the reaction: 5-beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH. MF
GO:0048518 positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. BP
GO:0048519 negative regulation of biological process Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. BP
GO:0047751 cholestenone 5-alpha-reductase activity Catalysis of the reaction: 5-alpha-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH. MF
GO:0047750 cholestenol delta-isomerase activity Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. MF
GO:0015725 gluconate transport The directed movement of gluconate into, out of, within or between cells. Gluconate is the aldonic acid derived from glucose. BP
GO:0015724 formate transport The directed movement of formate into, out of, within or between cells. BP
GO:0015727 lactate transport The directed movement of lactate into, out of, within or between cells. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. BP
GO:0015726 L-idonate transport The directed movement of L-idonate into, out of, within or between cells. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. BP
GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009149 pyrimidine nucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009140 pyrimidine nucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009141 nucleoside triphosphate metabolic process The chemical reactions and pathways involving a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009142 nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009143 nucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009144 purine nucleoside triphosphate metabolic process The chemical reactions and pathways involving purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009145 purine nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009146 purine nucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009147 pyrimidine nucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0006818 hydrogen transport The directed movement of hydrogen (H2 or H+), into, out of, within or between cells. BP
GO:0018425 O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds. BP
GO:0018424 peptidyl-glutamic acid poly-ADP-ribosylation This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way. BP
GO:0003726 double-stranded RNA adenosine deaminase activity NA MF
GO:0008899 homoserine O-succinyltransferase activity Catalysis of the reaction: succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine. MF
GO:0008898 homocysteine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. MF
GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. BP
GO:0008895 heme lyase disulfide oxidoreductase activity NA MF
GO:0008894 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. MF
GO:0008897 phosphopantetheinyltransferase activity Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. MF
GO:0018426 O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage. BP
GO:0008891 glycolate oxidase activity Catalysis of the reaction: glycolate + O2 = glyoxylate + H2O2. MF
GO:0003724 RNA helicase activity Catalysis of the unwinding of an RNA helix. MF
GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. MF
GO:0008892 guanine deaminase activity Catalysis of the reaction: guanine + H2O = xanthine + NH3. MF
GO:0018429 copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide. BP
GO:0003725 double-stranded RNA binding Interacting selectively with double-stranded RNA. MF
GO:0018428 copper incorporation into copper-sulfur cluster The incorporation of copper into a copper-sulfur cluster. BP
GO:0003723 RNA binding Interacting selectively with an RNA molecule or a portion thereof. MF
GO:0003720 telomerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. MF
GO:0003721 telomeric template RNA reverse transcriptase activity Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. MF
GO:0052428 modification by host of symbiont protein function The process by which an organism effects a change in the function of proteins in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0008239 dipeptidyl-peptidase activity Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. MF
GO:0008238 exopeptidase activity Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. MF
GO:0008231 repressor ecdysone receptor holocomplex NA CC
GO:0008230 ecdysone receptor holocomplex A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes. CC
GO:0008233 peptidase activity Catalysis of the hydrolysis of peptide bonds. MF
GO:0008232 activator ecdysone receptor holocomplex NA CC
GO:0008235 metalloexopeptidase activity Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. MF
GO:0008234 cysteine-type peptidase activity Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. MF
GO:0008237 metallopeptidase activity NA MF
GO:0008236 serine-type peptidase activity Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center. MF
GO:0010145 fructan metabolic process The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues. BP
GO:0002578 negative regulation of antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. BP
GO:0002579 positive regulation of antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. BP
GO:0002574 thrombocyte differentiation The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis. BP
GO:0002575 basophil chemotaxis The movement of a basophil in response to an external stimulus. BP
GO:0002576 platelet degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. BP
GO:0002577 regulation of antigen processing and presentation Any process that modulates the frequency, rate, or extent of antigen processing and presentation. BP
GO:0002570 somatic diversification of immunoglobulin genes by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. BP
GO:0002571 somatic diversification of T cell receptor genes by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene. BP
GO:0002572 pro-T cell differentiation The process whereby an unspecialized hemopoietic stem cell acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. BP
GO:0002573 myeloid leukocyte differentiation The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. BP
GO:0032692 negative regulation of interleukin-1 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. BP
GO:0032693 negative regulation of interleukin-10 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. BP
GO:0032690 negative regulation of interleukin-1 alpha production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production. BP
GO:0032691 negative regulation of interleukin-1 beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. BP
GO:0032696 negative regulation of interleukin-13 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production. BP
GO:0032697 negative regulation of interleukin-14 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production. BP
GO:0032694 negative regulation of interleukin-11 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production. BP
GO:0032695 negative regulation of interleukin-12 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. BP
GO:0032698 negative regulation of interleukin-15 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production. BP
GO:0032699 negative regulation of interleukin-16 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production. BP
GO:0042248 maintenance of polarity of follicular epithelium The maintenance of an established polarized follicular epithelial sheet. BP
GO:0042249 establishment of polarity of embryonic epithelium The specification and formation of a polarized embryonic epithelial sheet. BP
GO:0042242 cobyrinic acid a,c-diamide synthase activity Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide. MF
GO:0042243 spore wall assembly (sensu Bacteria) The chemical reactions and pathways resulting in the formation of the specialized envelope lying outside the cell membrane of a spore, as in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). BP
GO:0042240 interleukin-23 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-23. BP
GO:0042241 interleukin-18 biosynthetic process The chemical reactions and pathways resulting in the formation of interleukin-18. BP
GO:0042246 tissue regeneration The regrowth of lost or destroyed tissues. BP
GO:0042247 establishment of polarity of follicular epithelium The specification and formation of a polarized follicular epithelial sheet. BP
GO:0042244 spore wall assembly The chemical reactions and pathways resulting in the formation of the specialized envelope lying outside the cell membrane of a spore. BP
GO:0042245 RNA repair The various processes by which damaged RNA can be repaired. BP
GO:0005089 Rho guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0005088 Ras guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0005081 receptor signaling protein serine/threonine phosphatase signaling protein activity NA MF
GO:0048890 lateral line ganglion development The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear. BP
GO:0005083 small GTPase regulator activity Modulates the rate of GTP hydrolysis by a small monomeric GTPase. MF
GO:0005082 receptor signaling protein tyrosine phosphatase signaling protein activity NA MF
GO:0048895 lateral line nerve glial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve. BP
GO:0005084 Rab escort protein activity Interacting selectively with newly synthesized Rab protein to facilitate prenylation of Rab; interaction persists during membrane delivery of prenylated Rab. MF
GO:0048897 myelination of lateral line nerve axons The formation of compact myelin sheaths around the axons of a lateral line nerve. BP
GO:0005086 ARF guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0000222 plasma membrane hydrogen ion transporting ATPase V0 domain NA CC
GO:0000223 plasma membrane hydrogen ion transporting ATPase V1 domain NA CC
GO:0000220 hydrogen ion transporting ATPase V0 domain The integral domain of the V-type ATPase comprises the pore through the membrane, through which protons are translocated. CC
GO:0000221 hydrogen ion transporting ATPase V1 domain The peripheral domain of the V-type ATPase contains the section responsible for ATP hydrolysis. CC
GO:0000226 microtubule cytoskeleton organization and biogenesis The assembly and arrangement of cytoskeletal structures comprising microtubules and their associated proteins. BP
GO:0000227 oxaloacetate carrier activity NA MF
GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. MF
GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI. MF
GO:0000228 nuclear chromosome A chromosome found in the nucleus of a eukaryotic cell. CC
GO:0000229 cytoplasmic chromosome A chromosome found in the cytoplasm. CC
GO:0004932 mating-type factor pheromone receptor activity Combining with a mating-type factor pheromone to initiate a change in cell activity. MF
GO:0004933 mating-type a-factor pheromone receptor activity Combining with the mating-type a-factor pheromone to initiate a change in cell activity. MF
GO:0004930 G-protein coupled receptor activity A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. MF
GO:0004931 ATP-gated cation channel activity NA MF
GO:0004936 alpha-adrenergic receptor activity NA MF
GO:0004937 alpha1-adrenergic receptor activity NA MF
GO:0004934 mating-type alpha-factor pheromone receptor activity Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity. MF
GO:0004935 adrenoceptor activity NA MF
GO:0004938 alpha2-adrenergic receptor activity NA MF
GO:0004939 beta-adrenergic receptor activity NA MF
GO:0006682 galactosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. BP
GO:0006683 galactosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. BP
GO:0006680 glucosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. BP
GO:0006681 galactosylceramide metabolic process The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. BP
GO:0006686 sphingomyelin biosynthetic process The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. BP
GO:0006687 glycosphingolipid metabolic process The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. BP
GO:0006684 sphingomyelin metabolic process The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. BP
GO:0006685 sphingomyelin catabolic process The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. BP
GO:0006688 glycosphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. BP
GO:0006689 ganglioside catabolic process The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues. BP
GO:0005333 norepinephrine transporter activity Enables the directed movement of norepinephrine into, out of, within or between cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. MF
GO:0005332 gamma-aminobutyric acid:sodium symporter activity Catalysis of the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in). MF
GO:0005330 dopamine:sodium symporter activity Catalysis of the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in). MF
GO:0005337 nucleoside transporter activity Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of, within or between cells. MF
GO:0005335 serotonin:sodium symporter activity Catalysis of the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in). MF
GO:0005334 norephinephrine:sodium symporter activity Catalysis of the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in). MF
GO:0005338 nucleotide-sugar transporter activity Enables the directed movement of nucleotide-sugars into, out of, within or between cells. A nucleotide-sugars is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. MF
GO:0004684 calmodulin-dependent protein kinase I activity Catalysis of the reaction: ATP + protein = ADP + O-phosphoprotein. MF
GO:0004685 calcium- and calmodulin-dependent protein kinase activity Catalysis of the reaction: ATP + protein = ADP + O-phosphoprotein. MF
GO:0004686 eukaryotic elongation factor-2 kinase activity Catalysis of the phosphorylation of eukaryotic elongation factor-2. MF
GO:0004687 myosin light chain kinase activity Catalysis of the reaction: ATP + (myosin-light-chain) = ADP + (myosin-light-chain) phosphate. MF
GO:0004680 casein kinase activity NA MF
GO:0004681 casein kinase I activity NA MF
GO:0004682 protein kinase CK2 activity Catalysis of the reaction: casein + ATP = phosphocasein + ADP. MF
GO:0004683 calmodulin regulated protein kinase activity NA MF
GO:0004688 multifunctional calcium- and calmodulin-regulated protein kinase activity NA MF
GO:0004689 phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. MF
GO:0010089 xylem histogenesis The formation of the principal water-conducting tissue of a vascular plant. BP
GO:0010088 phloem histogenesis The formation of the principal food-conducting tissue of a vascular plant. BP
GO:0010087 vascular tissue development (sensu Tracheophyta) The process whose specific outcome is the progression of conducting tissues over time, from formation to the mature structure. As in, but not restricted to, the vascular plants (Tracheophyta, ncbi_taxonomy_id:58023). BP
GO:0010086 embryonic root morphogenesis The process by which the anatomical structures of the embryonic root are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0010085 polarity specification of proximal/distal axis The processes resulting in the establishment of polarity along the proximal/distal axis. BP
GO:0010084 specification of organ axis polarity The process by which the polarity of an organ axis is specified. BP
GO:0010083 regulation of vegetative meristem size The processes involved in maintaining the size and shape of a vegetative meristem. BP
GO:0010082 regulation of root meristem size The processes involved in maintaining the size and shape of a root meristem. BP
GO:0010081 regulation of inflorescence meristem size The processes involved in maintaining the size and shape of an inflorescence meristem. BP
GO:0010080 regulation of floral meristem size The processes involved in maintaining the size and shape of a floral meristem. BP
GO:0018252 peptide cross-linking via L-seryl-5-imidazolinone glycine The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. BP
GO:0018253 peptide cross-linking via 5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde. BP
GO:0018250 peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG. BP
GO:0018251 peptidyl-tyrosine dehydrogenation The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues. BP
GO:0018256 protein amino acid formylation The addition of a formyl group to a protein amino acid. BP
GO:0018257 peptidyl-lysine formylation The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine. BP
GO:0018254 peptidyl-tyrosine adenylylation The posttranslational adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine. BP
GO:0018255 peptide cross-linking via S-glycyl-L-cysteine The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins. BP
GO:0018258 protein amino acid O-linked glycosylation via hydroxyproline The posttranslational glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline. BP
GO:0018259 RNA-protein covalent cross-linking via peptidyl-serine The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine. BP
GO:0015567 alkane transporter activity Enables the directed movement of alkanes into, out of, within or between cells. Alkanes are saturated aliphatic hydrocarbon compounds. MF
GO:0015566 acriflavin transporter activity Enables the directed movement of acriflavin into, out of, within or between cells. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. MF
GO:0015565 threonine efflux permease activity NA MF
GO:0015564 multidrug, alkane resistant pump activity NA MF
GO:0015563 uptake permease activity Catalysis of the stereospecific transfer of a substrate across a biological membrane into a cell. MF
GO:0015562 efflux permease activity Catalysis of the stereospecific transfer of a substrate across a biological membrane out of a cell. MF
GO:0015561 rhamnose:hydrogen symporter activity Catalysis of the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in). MF
GO:0007242 intracellular signaling cascade A series of reactions within the cell that occur as a result of a single trigger reaction or compound. BP
GO:0007249 I-kappaB kinase/NF-kappaB cascade A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase. BP
GO:0015569 p-aminobenzoyl-glutamate transporter activity Enables the directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of, within or between cells. MF
GO:0015568 L-idonate transporter activity Enables the directed movement of L-idonate into, out of, within or between cells. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. MF
GO:0019615 catechol catabolic process, ortho-cleavage The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups. BP
GO:0019614 catechol catabolic process The chemical reactions and pathways resulting in the breakdown of catechol, a compound containing a pyrocatechol nucleus or substituent. BP
GO:0019617 protocatechuate catabolic process, meta-cleavage NA BP
GO:0019616 catechol catabolic process, meta-cleavage The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom. BP
GO:0019611 4-toluenecarboxylate metabolic process The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule. BP
GO:0019610 3-hydroxyphenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. BP
GO:0019613 bile acid 7alpha-dehydroxylation pathway NA BP
GO:0019612 4-toluenecarboxylate catabolic process The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule. BP
GO:0019619 protocatechuate catabolic process The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid. BP
GO:0019618 protocatechuate catabolic process, ortho-cleavage NA BP
GO:0046083 adenine metabolic process The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. BP
GO:0021878 forebrain astrocyte fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain. BP
GO:0021879 forebrain neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain. BP
GO:0021876 Notch signaling pathway in forebrain neuroblast division The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain. BP
GO:0021877 forebrain neuron fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. BP
GO:0021874 Wnt receptor signaling pathway in forebrain neuroblast division The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain. BP
GO:0021875 fibroblast growth factor receptor signaling pathway in forebrain neuroblast division The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain. BP
GO:0021872 generation of neurons in the forebrain The process by which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. BP
GO:0021873 forebrain neuroblast division The division of a neuroblast, the neural precursor in the forebrain, giving rise to at least another neuroblast. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0021870 Cajal-Retzius cell differentiation The process whereby a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene. BP
GO:0021871 forebrain regionalization The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. BP
GO:0016034 maleylacetoacetate isomerase activity Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. MF
GO:0016035 zeta DNA polymerase complex A low fidelity DNA-directed DNA polymerase that functions during replication, to promote the extension of forks whose progression is stopped for any reason; a non-processive enzyme with no 3'-5' exonuclease activity; possesses deoxycytidyl transferase activity, incorporating deoxycytidyl opposite abasic sites. Functions during DNA repair and mutagenesis. Composed of two subunits. CC
GO:0016036 cellular response to phosphate starvation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. BP
GO:0016037 absorption of light The reception of a photon by a cell. BP
GO:0016030 metarhodopsin binding Interacting selectively with metarhodopsin, a transient intermediate produced upon irradiation of rhodopsin in the visual cycle and existing in two forms, metarhodopsins I and II. The latter dissociates to form opsin and all-trans retinal. MF
GO:0016031 cytoplasmic tRNA import into mitochondrion The directed movement of cytoplasmic tRNA into a mitochondrion. BP
GO:0016032 viral reproduction The process by which a virus reproduces. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. BP
GO:0016038 absorption of visible light The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm. BP
GO:0016039 absorption of UV light The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm. BP
GO:0004398 histidine decarboxylase activity Catalysis of the reaction: L-histidine = histamine + CO2. MF
GO:0051168 nuclear export The directed movement of substances out of the nucleus. BP
GO:0004392 heme oxygenase (decyclizing) activity Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. MF
GO:0051167 xylulose 5-phosphate metabolic process The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway. BP
GO:0004397 histidine ammonia-lyase activity Catalysis of the reaction: L-histidine = urocanate + NH3. MF
GO:0004394 heparan sulfate 2-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. MF
GO:0051164 L-xylitol metabolic process The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets. BP
GO:0031770 growth hormone-releasing hormone receptor binding Interacting selectively with a growth hormone-releasing hormone receptor. MF
GO:0031771 type 1 hypocretin receptor binding Interacting selectively with a type 1 hypocretin receptor. MF
GO:0031772 type 2 hypocretin receptor binding Interacting selectively with a type 2 hypocretin receptor. MF
GO:0031773 kisspeptin receptor binding Interacting selectively with a kisspeptin receptor. MF
GO:0031774 leukotriene receptor binding Interacting selectively with a leukotriene receptor. MF
GO:0031775 lutropin-choriogonadotropic hormone receptor binding Interacting selectively with a lutropin-choriogonadotropic hormone receptor. MF
GO:0031776 melanin-concentrating hormone receptor binding Interacting selectively with a melanin-concentrating hormone receptor. MF
GO:0031777 type 1 melanin-concentrating hormone receptor binding Interacting selectively with a type 1 melanin-concentrating hormone receptor. MF
GO:0031778 type 2 melanin-concentrating hormone receptor binding Interacting selectively with a type 2 melanin-concentrating hormone receptor. MF
GO:0031779 melanocortin receptor binding Interacting selectively with a melanocortin receptor. MF
GO:0051978 lysophospholipid transporter activity Enables the directed movement of lysophospholipids into, out of, within or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. MF
GO:0051979 alginic acid acetylation The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate. BP
GO:0017078 Hsc70 protein regulator activity Binds to and modulates the activity of the molecular chaperone Hsc70. MF
GO:0017077 oxidative phosphorylation uncoupler activity NA MF
GO:0051975 lysine biosynthetic process via alpha-aminoadipate and saccharopine The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine. BP
GO:0051976 lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine. BP
GO:0051977 lysophospholipid transport The directed movement of phospholipids into, out of, within or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. BP
GO:0051970 negative regulation of transmission of nerve impulse Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. BP
GO:0051971 positive regulation of transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. BP
GO:0051972 regulation of telomerase activity Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. BP
GO:0017070 U6 snRNA binding Interacting selectively with the U6 small nuclear RNA (U6 snRNA). MF
GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. BP
GO:0009309 amine biosynthetic process The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. BP
GO:0009306 protein secretion The regulated release of proteins from a cell or group of cells. BP
GO:0009307 DNA restriction-modification system The processes that protect an organism from invading foreign DNA by methylation of self DNA at specific sequences and nucleolytic cleavage of unmethylated foreign DNA. BP
GO:0009304 tRNA transcription The synthesis of transfer RNA (tRNA) from a DNA template. BP
GO:0009305 protein amino acid biotinylation The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid. BP
GO:0009302 snoRNA transcription The synthesis of small nucleolar RNA (snoRNA) from a DNA template. BP
GO:0009303 rRNA transcription The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. BP
GO:0009300 antisense RNA transcription The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. BP
GO:0009301 snRNA transcription The synthesis of small nuclear RNA (snRNA) from a DNA template. BP
GO:0016856 racemase and epimerase activity, acting on hydroxy acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule. MF
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. MF
GO:0016854 racemase and epimerase activity Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. MF
GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. MF
GO:0016852 sirohydrochlorin cobaltochelatase activity Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+. MF
GO:0016853 isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. MF
GO:0016851 magnesium chelatase activity Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. MF
GO:0016859 cis-trans isomerase activity Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. MF
GO:0051439 regulation of ubiquitin ligase activity during mitotic cell cycle A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle. BP
GO:0005897 interleukin-9 receptor complex Complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins. CC
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. MF
GO:0051437 positive regulation of ubiquitin ligase activity during mitotic cell cycle Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the mitotic cell cycle. BP
GO:0004029 aldehyde dehydrogenase (NAD) activity Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. MF
GO:0045364 negative regulation of interleukin-11 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11. BP
GO:0045365 positive regulation of interleukin-11 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11. BP
GO:0045366 regulation of interleukin-13 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13. BP
GO:0045367 negative regulation of interleukin-13 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13. BP
GO:0045360 regulation of interleukin-1 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1. BP
GO:0045361 negative regulation of interleukin-1 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1. BP
GO:0045362 positive regulation of interleukin-1 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1. BP
GO:0045363 regulation of interleukin-11 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11. BP
GO:0045368 positive regulation of interleukin-13 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13. BP
GO:0045369 regulation of interleukin-14 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14. BP
GO:0004024 alcohol dehydrogenase activity, zinc-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. MF
GO:0004025 alcohol dehydrogenase activity, iron-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. MF
GO:0051297 centrosome organization and biogenesis The assembly and arrangement of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. BP
GO:0051296 establishment of meiotic spindle orientation The processes that set the alignment of meiotic spindle relative to other cellular structures. BP
GO:0004020 adenylylsulfate kinase activity Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. MF
GO:0051290 protein heterotetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated nonidentical subunits. BP
GO:0051293 establishment of spindle localization The directed movement of the spindle to a specific location in the cell. BP
GO:0004023 alcohol dehydrogenase activity, metal ion-independent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. MF
GO:0032450 maltase activity Catalysis of the hydrolysis of maltose by an alpha-D-glucosidase-type action. MF
GO:0032451 demethylase activity Catalysis of the removal of a methyl group from a substrate. MF
GO:0032452 histone demethylase activity Catalysis of the removal of a methyl group from a histone. MF
GO:0032453 histone demethylase activity (H3-K4 specific) Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein. MF
GO:0032454 histone demethylase activity (H3-K9 specific) Catalysis of the removal of a methyl group from lysine at position 9 of the histone H3 protein. MF
GO:0032455 nerve growth factor processing The generation of a mature nerve growth factor by proteolysis of a precursor. BP
GO:0032456 endocytic recycling The directed movement of membrane-bound vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. BP
GO:0032457 fast endocytic recycling The directed movement of membrane-bound vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. BP
GO:0032458 slow endocytic recycling The directed movement of membrane-bound vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. BP
GO:0032459 regulation of protein oligomerization Any process that modulates the frequency, rate or extent of protein oligomerization. BP
GO:0006277 DNA amplification The process by which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. BP
GO:0015009 corrin metabolic process The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. BP
GO:0047218 hydroxycinnamate 4-beta-glucosyltransferase activity Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP. MF
GO:0047219 monoterpenol beta-glucosyltransferase activity Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl O-beta-D-glucoside + UDP. MF
GO:0047216 inositol 3-alpha-galactosyltransferase activity Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP. MF
GO:0047217 sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose. MF
GO:0047214 cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP. MF
GO:0047215 indole-3-acetate beta-glucosyltransferase activity Catalysis of the reaction: auxin + UDP-D-glucose = indole-3-acetyl-beta-1-D-glucose + UDP. MF
GO:0047212 2-coumarate O-beta-glucosyltransferase activity Catalysis of the reaction: 2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + UDP. MF
GO:0047213 anthocyanidin 3-O-glucosyltransferase activity Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. MF
GO:0047210 alpha-1,4-glucan-protein synthase (UDP-forming) activity Catalysis of the reaction: protein + UDP-D-glucose = alpha-D-glucosyl-protein + UDP. MF
GO:0047211 alpha-1,4-glucan-protein synthase (ADP-forming) activity Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP. MF
GO:0035244 peptidyl-arginine C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. MF
GO:0035245 peptidyl-arginine C-methylation The addition of a methyl group onto a carbon atom of an arginine residue in a protein. BP
GO:0035246 peptidyl-arginine N-methylation The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein. BP
GO:0035247 peptidyl-arginine omega-N-methylation The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein. BP
GO:0035240 dopamine binding Interacting selectively with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. MF
GO:0035241 protein-arginine omega-N monomethyltransferase activity Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. MF
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. MF
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. MF
GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage. MF
GO:0035249 synaptic transmission, glutamatergic The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. BP
GO:0002168 larval development (sensu Insecta) The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030148 sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). BP
GO:0030149 sphingolipid catabolic process The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). BP
GO:0030140 trans-Golgi network transport vesicle A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. CC
GO:0030141 secretory granule A small subcellular vesicle, surrounded by a single-layered membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. CC
GO:0030142 Golgi to ER transport vesicle A vesicle that mediates transport from the Golgi to the endoplasmic reticulum. CC
GO:0030143 inter-Golgi transport vesicle A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack). CC
GO:0030144 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. MF
GO:0030145 manganese ion binding Interacting selectively with manganese (Mn) ions. MF
GO:0030146 diuresis A process that increases urine production; from the definition 'increased or excessive flow of urine'. BP
GO:0030147 natriuresis The excretion of sodium ions in the urine. BP
GO:0031899 chromoplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma. CC
GO:0031898 chromoplast envelope The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. CC
GO:0031895 V1B vasopressin receptor binding Interacting selectively with a V1B vasopressin receptor. MF
GO:0031894 V1A vasopressin receptor binding Interacting selectively with a V1A vasopressin receptor. MF
GO:0031897 Tic complex The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane. CC
GO:0031896 V2 vasopressin receptor binding Interacting selectively with a V2 vasopressin receptor. MF
GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding Interacting selectively with a type 1 vasoactive intestinal polypeptide receptor. MF
GO:0031890 vasoactive intestinal polypeptide receptor binding Interacting selectively with a vasoactive intestinal polypeptide receptor. MF
GO:0031893 vasopressin receptor binding Interacting selectively with a vasopressin receptor. MF
GO:0031892 type 2 vasoactive intestinal polypeptide receptor binding Interacting selectively with a type 2 vasoactive intestinal polypeptide receptor. MF
GO:0043018 negative regulation of tumor necrosis factor-beta biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine tumor necrosis factor-beta. BP
GO:0043014 alpha-tubulin binding Interacting selectively with the microtubule constituent protein alpha-tubulin. MF
GO:0043015 gamma-tubulin binding Interacting selectively with the microtubule constituent protein gamma-tubulin. MF
GO:0043016 regulation of tumor necrosis factor-beta biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine tumor necrosis factor-beta. BP
GO:0043017 positive regulation of tumor necrosis factor-beta biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine tumor necrosis factor-beta. BP
GO:0043010 eye development (sensu Vertebrata) The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043011 myeloid dendritic cell differentiation The process by which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. BP
GO:0043012 regulation of fusion of sperm to egg plasma membrane Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane. BP
GO:0043013 negative regulation of fusion of sperm to egg plasma membrane Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane. BP
GO:0048301 positive regulation of isotype switching to IgD isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes. BP
GO:0048300 negative regulation of isotype switching to IgD isotypes Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgD isotypes. BP
GO:0048303 negative regulation of isotype switching to IgG isotypes Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgG isotypes. BP
GO:0048302 regulation of isotype switching to IgG isotypes Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes. BP
GO:0048305 immunoglobulin secretion The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin. BP
GO:0048304 positive regulation of isotype switching to IgG isotypes Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes. BP
GO:0048307 ferredoxin-nitrite reductase activity Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = NO2(-) (nitrite) + 6 reduced ferredoxin + 7 H+. MF
GO:0048306 calcium-dependent protein binding Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. MF
GO:0048309 endoplasmic reticulum inheritance The partitioning of endoplasmic reticulum between daughter cells at cell division. BP
GO:0048308 organelle inheritance The partitioning of organelles between daughter cells at cell division. BP
GO:0015654 tellurite-resistance uptake permease activity Catalysis of the reaction: tellurite(out) + H+(out) = tellurite(in) + H+(in). MF
GO:0031239 intrinsic to external side of plasma membrane, in periplasmic space (sensu ProteoBacteria) Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0031238 extrinsic to external side of plasma membrane, in periplasmic space (sensu ProteoBacteria) Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0042659 regulation of cell fate specification Any process that mediates the adoption of a specific fate by a cell. BP
GO:0042658 MHC class II protein binding, via antigen binding groove Interacting selectively with the antigen binding groove of major histocompatibility complex class II molecules. MF
GO:0042655 activation of JNKKK activity The initiation of the activity of the inactive enzyme JUN kinase kinase kinase activity in response to phosphorylation by a member of the MAP kinase kinase kinase kinase (MAPKKKK) family or another upstream kinase. BP
GO:0042654 ecdysis-triggering hormone receptor activity Combining with ecdysis-triggering hormone to initiate a change in cell activity. MF
GO:0042657 MHC class II protein binding, via lateral surface Interacting selectively with the lateral surface of major histocompatibility complex class II molecules. MF
GO:0042656 JUN kinase kinase kinase kinase activity Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs). MF
GO:0031235 intrinsic to internal side of plasma membrane Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm. CC
GO:0042650 prothylakoid membrane The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. CC
GO:0042653 respiratory chain complex I, membrane segment (sensu Eukaryota) The membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0042652 respiratory chain complex I, peripheral segment (sensu Eukaryota) The peripheral segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0015657 branched-chain amino acid:sodium symporter activity Catalysis of the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in). MF
GO:0050551 myrcene synthase activity Catalysis of the reaction: geranyl diphosphate = myrcene + diphosphate. MF
GO:0050550 pinene synthase activity Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. MF
GO:0050553 taxadiene synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate. MF
GO:0050552 (4S)-limonene synthase activity Catalysis of the reaction: geranyl diphosphate = limonene + diphosphate. MF
GO:0050555 2-hydroxypropyl-CoM lyase activity Catalysis of the reaction: (R)-[or (S)-]2-hydroxypropyl-CoM = H-S-CoM + (R)-[or (S)-]1,2-epoxypropane. MF
GO:0050554 abietadiene synthase activity Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate. MF
GO:0050557 deacetylipecoside synthase activity Catalysis of the reaction: dopamine + secologanin = deacetylipecoside + H2O. MF
GO:0050556 deacetylisoipecoside synthase activity Catalysis of the reaction: dopamine + secologanin = deacetylisoipecoside + H2O. MF
GO:0050559 copalyl diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = (+)-copalyl diphosphate. MF
GO:0050558 maltose epimerase activity Catalysis of the reaction: alpha-maltose = beta-maltose. MF
GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide. MF
GO:0008919 lipopolysaccharide glucosyltransferase I activity Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide. MF
GO:0008910 kanamycin kinase activity Catalysis of the reaction: ATP + kanamycin = ADP + kanamycin 3'-phosphate. MF
GO:0008911 lactaldehyde dehydrogenase activity Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+. MF
GO:0008912 lactaldehyde reductase activity Catalysis of the reaction: (R) (or (S))-propane-1,2-diol + NAD+ = (R) (or (S))-lactaldehyde + NADH + H+. MF
GO:0008913 lauroyl transferase activity Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another. MF
GO:0008914 leucyltransferase activity Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein. MF
GO:0008915 lipid-A-disaccharide synthase activity Catalysis of the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. MF
GO:0008916 lipoate-protein ligase A activity NA MF
GO:0008917 lipopolysaccharide N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide. MF
GO:0050089 mannose isomerase activity Catalysis of the reaction: D-mannose = D-fructose. MF
GO:0050088 mannose-6-phosphate 6-reductase activity Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH. MF
GO:0050083 malyl-CoA lyase activity Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate. MF
GO:0050082 maltose phosphorylase activity Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate. MF
GO:0050081 maltose-6'-phosphate glucosidase activity Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate. MF
GO:0050080 malonyl-CoA decarboxylase activity Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. MF
GO:0050087 mannitol dehydrogenase (cytochrome) activity Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c. MF
GO:0050086 mannitol 2-dehydrogenase activity Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH. MF
GO:0050085 mannitol 2-dehydrogenase (NADP+) activity Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + NADPH. MF
GO:0043679 nerve terminal The nerve ending is the structure in which the distal end of the axon of a nerve fiber terminates. Sensory nerve endings are classified as either free or encapsulated. The free nerve ending are the most common type of nerve ending, and are most frequently found in the skin. CC
GO:0008645 hexose transport The directed movement of hexose into, out of, within or between cells. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. BP
GO:0008646 high-affinity hexose transport NA BP
GO:0043677 germination pore A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location. CC
GO:0043671 endexine The inner part of the exine, which stains. CC
GO:0043673 sexine The outer, sculptured layer of the exine, which lies above the nexine. CC
GO:0018987 osmoregulation The control of the osmotic activity of the fluid in a cell, tissue, organ, or organism. BP
GO:0018984 naphthalenesulfonate metabolic process The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene. BP
GO:0018985 pronuclear envelope synthesis Synthesis and ordering of the envelope of pronuclei. BP
GO:0018982 vanillin metabolic process The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin. BP
GO:0018983 Z-phenylacetaldoxime metabolic process The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants. BP
GO:0018980 2,4,5-trichlorophenoxyacetic acid metabolic process The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns. BP
GO:0018981 triethanolamine metabolic process The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. BP
GO:0018988 molting cycle (sensu Protostomia and Nematoda) The periodic shedding of part or all of a cuticle, which is then replaced by a new cuticle. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317), and the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0018989 apolysis The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells. BP
GO:0019059 initiation of viral infection Processes involved in the start of virus infection of cells. BP
GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. BP
GO:0019053 suppression by virus of host extracellular antiviral response Viral processes that result in the inhibition of extracellular (adaptive immune response) antiviral mechanisms, thereby facilitating viral replication. BP
GO:0019052 suppression by virus of host intracellular antiviral response Viral processes that result in the inhibition of intracellular (innate immune response) antiviral mechanisms, thereby facilitating viral replication. BP
GO:0019051 induction by virus of host apoptosis Viral processes that result in the induction of apoptosis of infected cells, facilitating release and spread of progeny virions. BP
GO:0019050 suppression by virus of host apoptosis Viral processes and gene products that result in the inhibition of apoptosis, facilitating prolonged cell survival during viral replication. BP
GO:0019057 modification by virus of host cell mRNA translation The modulation of transcription of cellular protein-coding genes by host RNA polymerase II. BP
GO:0019056 modification by virus of host cell transcription The modulation by viral gene products of host RNA polymerase II facilitated transcription. BP
GO:0019055 modification by virus of host cell cycle regulation Viral processes that modulate the rate of the host cell cycle to facilitate virus replication. BP
GO:0019054 modification by virus of host cellular process The process in which a virus effects a change in the cellular pathways and activities of its host organism. BP
GO:0032159 septin cap A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentiously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. CC
GO:0032158 septin band A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. CC
GO:0032151 mitotic septin complex A heterooligomeric septin complex that acts during mitotic cell division. CC
GO:0032150 ubiquinone biosynthetic process from chorismate The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate. BP
GO:0032153 cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane. CC
GO:0032152 meiotic septin complex A heterooligomeric septin complex that acts during meiotic cell division. CC
GO:0032155 cell division site part Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell. CC
GO:0032154 cleavage furrow In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin, is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists. CC
GO:0032157 prospore contractile ring A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis. CC
GO:0032156 septin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes. CC
GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, beginning with the synthesis of a purine ring from simpler precursors. BP
GO:0006188 IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. BP
GO:0006185 dGDP biosynthetic process The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). BP
GO:0006184 GTP catabolic process The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate. BP
GO:0006187 dGTP biosynthetic process from dGDP The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate. BP
GO:0006186 dGDP phosphorylation The process of introducing a phosphoric group into dGDP, deoxyguanosine diphosphate, to produce dGTP. BP
GO:0006181 dGMP biosynthetic process The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate). BP
GO:0006180 deoxyguanosine salvage Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis. BP
GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. BP
GO:0006182 cGMP biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. BP
GO:0055017 cardiac muscle growth The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. BP
GO:0055015 ventricular cardiac muscle cell development The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood away from the organ. BP
GO:0055013 cardiac muscle cell development The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. BP
GO:0055012 ventricular cardiac muscle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood away from the organ. BP
GO:0005988 lactose metabolic process The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose. BP
GO:0005989 lactose biosynthetic process The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose. BP
GO:0055011 atrial cardiac muscle cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that allows blood to return to the organ. BP
GO:0005980 glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. BP
GO:0005981 regulation of glycogen catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. BP
GO:0005982 starch metabolic process The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose. BP
GO:0055010 ventricular cardiac muscle morphogenesis The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0005984 disaccharide metabolic process The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units. BP
GO:0005985 sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. BP
GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. BP
GO:0005987 sucrose catabolic process The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside. BP
GO:0006729 tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. BP
GO:0006728 pteridine biosynthetic process The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. BP
GO:0006721 terpenoid metabolic process The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. BP
GO:0006720 isoprenoid metabolic process The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. BP
GO:0006723 cuticle hydrocarbon biosynthetic process The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss. BP
GO:0006722 triterpenoid metabolic process The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units. BP
GO:0006725 aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons. BP
GO:0006727 ommochrome biosynthetic process The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. BP
GO:0006726 eye pigment biosynthetic process The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. BP
GO:0055019 negative regulation of cardiac muscle fiber development Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle fiber development. BP
GO:0055018 regulation of cardiac muscle fiber development Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. BP
GO:0000073 spindle pole body separation A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble. BP
GO:0000072 M phase specific microtubule process A microtubule-based process that occurs only during M phase of the cell cycle. BP
GO:0000070 mitotic sister chromatid segregation The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. BP
GO:0000077 DNA damage checkpoint A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. BP
GO:0000076 DNA replication checkpoint A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. BP
GO:0000075 cell cycle checkpoint A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. BP
GO:0000074 regulation of progression through cell cycle Any process that modulates the rate or extent of progression through the cell cycle. BP
GO:0000079 regulation of cyclin-dependent protein kinase activity Any process that modulates the frequency, rate or extent of CDK activity. BP
GO:0000078 cell morphogenesis checkpoint A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective. BP
GO:0004760 serine-pyruvate transaminase activity Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. MF
GO:0004767 sphingomyelin phosphodiesterase activity Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate. MF
GO:0004766 spermidine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. MF
GO:0004765 shikimate kinase activity Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. MF
GO:0004764 shikimate 5-dehydrogenase activity Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. MF
GO:0004769 steroid delta-isomerase activity Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. MF
GO:0004768 stearoyl-CoA 9-desaturase activity Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O. MF
GO:0018043 C-terminal peptidyl-isoleucine amidation The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein. BP
GO:0018042 C-terminal peptidyl-histidine amidation The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein. BP
GO:0018041 C-terminal peptidyl-glycine amidation The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein. BP
GO:0018040 C-terminal peptidyl-glutamic acid amidation The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein. BP
GO:0018047 C-terminal peptidyl-phenylalanine amidation The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein. BP
GO:0018046 C-terminal peptidyl-methionine amidation The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein. BP
GO:0018045 C-terminal peptidyl-lysine amidation The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein. BP
GO:0018044 C-terminal peptidyl-leucine amidation The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein. BP
GO:0018049 C-terminal peptidyl-serine amidation The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein. BP
GO:0018048 C-terminal peptidyl-proline amidation The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein. BP
GO:0016917 GABA receptor activity Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity. MF
GO:0016914 follicle-stimulating hormone complex A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity. CC
GO:0016913 follicle-stimulating hormone activity A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. MF
GO:0016919 nardilysin activity Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys. MF
GO:0016918 retinal binding Interacting selectively with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. MF
GO:0042075 nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. BP
GO:0042074 cell migration involved in gastrulation The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). BP
GO:0042077 protein amino acid phosphate-linked glycosylation via serine NA BP
GO:0047004 UDP-N-acetylglucosamine 6-dehydrogenase activity Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-D-glucosamine = 2 NADH + 2 H+ + UDP-N-acetyl-2-amino-d-glucuronate. MF
GO:0042071 leucokinin receptor activity Combining with a leucokinin, any of several octapeptide hormones found in insects, to initiate a change in cell activity. MF
GO:0042070 maintenance of oocyte nucleus localization during oocyte axis determination Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. BP
GO:0042073 intraflagellar transport The directed movement of substances within a flagellum. BP
GO:0051358 peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus. BP
GO:0051359 peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor. BP
GO:0051354 negative regulation of oxidoreductase activity Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. BP
GO:0051355 proprioception during equilibrioception The series of events during equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity. BP
GO:0051356 visual perception during equilibrioception The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity. BP
GO:0051357 peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. BP
GO:0051350 negative regulation of lyase activity Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. BP
GO:0051351 positive regulation of ligase activity Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. BP
GO:0051352 negative regulation of ligase activity Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. BP
GO:0051353 positive regulation of oxidoreductase activity Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. BP
GO:0015242 benomyl transporter activity Enables the directed movement of benomyl into, out of, within or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit. MF
GO:0015243 cycloheximide transporter activity Enables the directed movement of cycloheximide into, out of, within or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. MF
GO:0015240 amiloride transporter activity Enables the directed movement of amiloride of amiloride into, out of, within or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. MF
GO:0015241 aminotriazole transporter activity Enables the directed movement of aminotriazole into, out of, within or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity. MF
GO:0015246 fatty acyl transporter activity Enables the directed movement of a fatty acyl group into, out of, within or between cells. A fatty acyl group is any acyl group derived from a fatty acid. MF
GO:0015247 aminophospholipid transporter activity Enables the directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. MF
GO:0015244 fluconazole transporter activity Enables the directed movement of fluconazole into, out of, within or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. MF
GO:0015245 fatty acid transporter activity Enables the directed movement of fatty acids into, out of, within or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. MF
GO:0015248 sterol transporter activity Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. MF
GO:0015249 nonselective channel activity NA MF
GO:0021629 olfactory nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. BP
GO:0021628 olfactory nerve formation The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. BP
GO:0021627 olfactory nerve morphogenesis The process by which the anatomical structure of the olfactory nerve is generated and organized. Morphogenesis pertains to the creation of form. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. BP
GO:0021626 central nervous system maturation A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. BP
GO:0021625 oculomotor nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. BP
GO:0021624 oculomotor nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. BP
GO:0021623 oculomotor nerve formation The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. BP
GO:0021622 oculomotor nerve morphogenesis The process by which the anatomical structure of the oculomotor nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. BP
GO:0021621 hypoglossal nerve structural organization The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. BP
GO:0021620 hypoglossal nerve formation The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. BP
GO:0015794 glycerol-3-phosphate transport The directed movement of glycerol-3-phosphate into, out of, within or between cells. Glycerol-3-phosphate is a phosphoric monoester of glycerol. BP
GO:0015795 sorbitol transport The directed movement of sorbitol into, out of, within or between cells. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. BP
GO:0015796 galactitol transport The directed movement of galactitol into, out of, within or between cells. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. BP
GO:0015797 mannitol transport The directed movement of mannitol into, out of, within or between cells. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. BP
GO:0015790 UDP-xylose transport The directed movement of UDP-xylose into, out of, within or between cells. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. BP
GO:0015791 polyol transport The directed movement of polyols, any polyhydric alcohol, into, out of, within or between cells. BP
GO:0015792 arabinitol transport The directed movement of arabitol into, out of, within or between cells. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. BP
GO:0015793 glycerol transport The directed movement of glycerol into, out of, within or between cells. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. BP
GO:0001841 neural tube formation The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. BP
GO:0001840 neural plate development The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. BP
GO:0001843 neural tube closure The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. BP
GO:0001842 neural fold formation The process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. BP
GO:0001845 phagolysosome formation The process by which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome. BP
GO:0001844 protein insertion into mitochondrial membrane during induction of apoptosis The process by which a protein is incorporated into a mitochondrial membrane as an early step in apoptosis. BP
GO:0001847 opsonin receptor activity Combining with an opsonin to initiate a change in cell activity. MF
GO:0001846 opsonin binding Interacting selectively with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. MF
GO:0046017 regulation of transcription from RNA polymerase I promoter, mitotic A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis. BP
GO:0016264 gap junction assembly Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids. BP
GO:0016267 O-glycan processing, core 1 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-1->3-GalNAc. BP
GO:0016266 O-glycan processing The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form a core O-glycan structure. BP
GO:0016261 selenocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins. BP
GO:0016260 selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins. BP
GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan. MF
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. BP
GO:0016269 O-glycan processing, core 3 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-1->3-GalNAc. BP
GO:0016268 O-glycan processing, core 2 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-1->6(Gal-beta-1->3)-GalNAc. BP
GO:0046019 regulation of transcription from RNA polymerase II promoter by pheromones Any process involving pheromones that modulates the frequency, rate or extent or transcription from the RNA polymerase II promoter. BP
GO:0046018 positive regulation of transcription from RNA polymerase I promoter, mitotic Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis. BP
GO:0030308 negative regulation of cell growth Any process that stops, prevents or reduces the frequency, rate or extent of cell growth. BP
GO:0030309 poly-N-acetyllactosamine metabolic process The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. BP
GO:0030306 ADP-ribosylation factor binding Interacting selectively with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells. MF
GO:0030307 positive regulation of cell growth Any process that activates or increases the frequency, rate or extent of cell growth. BP
GO:0030304 trypsin inhibitor activity Stops, prevents or reduces the activity of the serine endopeptidase trypsin. MF
GO:0030305 heparanase activity Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. MF
GO:0030302 deoxynucleotide transport Transport of deoxynucleotides: a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of its deoxyribose moiety. BP
GO:0030303 stromelysin 2 activity Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak. MF
GO:0030300 regulation of cholesterol absorption Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption. BP
GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells. BP
GO:0017132 cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase; dependent on the presence of a cyclic nucleotide. MF
GO:0017133 electron transfer flavoprotein complex (sensu Eukaryota) A protein complex found in eukaryotes containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0017130 poly(rC) binding Interacting selectively with a sequence of cytosine residues in an RNA molecule. MF
GO:0017131 uridine-rich cytoplasmic polyadenylylation element binding Interacting selectively with U-rich sequence in the 3'-end of mRNAs; required for cytoplasmic polyadenylylation. MF
GO:0017136 NAD-dependent histone deacetylase activity Catalysis of the removal of acetyl groups from histones, requiring NAD. MF
GO:0017137 Rab GTPase binding Interacting selectively with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. MF
GO:0017134 fibroblast growth factor binding Interacting selectively with fibroblast growth factor. MF
GO:0042747 circadian sleep/wake cycle, REM sleep A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity. BP
GO:0042746 circadian sleep/wake cycle, wakefulness The part of the circadian sleep/wake cycle where the organism is not asleep. BP
GO:0042745 circadian sleep/wake cycle The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. BP
GO:0042744 hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). BP
GO:0042743 hydrogen peroxide metabolic process The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. BP
GO:0042742 defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. BP
GO:0042741 endogenous antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism. BP
GO:0045098 type III intermediate filament A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments. CC
GO:0045094 interleukin-18 beta subunit binding Interacting selectively with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a. MF
GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. CC
GO:0045092 interleukin-18 receptor complex Complex that binds interleukin-18; comprises an alpha and a beta subunit. CC
GO:0045093 interleukin-18 alpha subunit binding Interacting selectively with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells. MF
GO:0045090 retroviral genome replication Any process involved in the replication of a retroviral genome. Retroviruses use RNA as their nucleic acid and reverse transcriptase to copy their genome into the DNA of the host cells chromosomes. BP
GO:0045091 regulation of retroviral genome replication Any process that modulates the frequency, rate or extent of retroviral genome replication. BP
GO:0047829 D-nopaline dehydrogenase activity Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH. MF
GO:0047828 D-lyxose ketol-isomerase activity Catalysis of the reaction: D-lyxose = D-xylulose. MF
GO:0047825 D-lactate-2-sulfatase activity Catalysis of the reaction: (S)-2-O-sulfolactate + H2O = (S)-lactate + SO4(2-) (sulfate). MF
GO:0047824 D-iditol 2-dehydrogenase activity Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH. MF
GO:0047827 D-lysopine dehydrogenase activity Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O = L-lysine + pyruvate + NADPH. MF
GO:0047826 D-lysine 5,6-aminomutase activity Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate. MF
GO:0047821 D-glutamate oxidase activity Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2. MF
GO:0047820 D-glutamate cyclase activity Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O. MF
GO:0047823 D-glutamyltransferase activity Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide. MF
GO:0047822 hypotaurine dehydrogenase activity Catalysis of the reaction: hypotaurine + H2O + NAD+ = taurine + NADH. MF
GO:0022622 root system development The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure. BP
GO:0022620 vegetative cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube. BP
GO:0022621 shoot system development The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure. BP
GO:0009519 middle lamella Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells. CC
GO:0009518 PSI associated light-harvesting complex I Protein-pigment complex associated with photosystem I. CC
GO:0009517 PSII associated light-harvesting complex II Protein-pigment complex associated with photosystem II. CC
GO:0009516 leucoplast Colorless plastid involved in the synthesis of monoterpenes. CC
GO:0009515 granal stacked thylakoid Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II. CC
GO:0009514 glyoxysome A microbody that contains the enzymes of the glyoxylate pathway. CC
GO:0009513 etioplast A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions. CC
GO:0009512 cytochrome b6f complex Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. CC
GO:0009511 plasmodesmatal endoplasmic reticulum Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells. CC
GO:0009510 plasmodesmatal desmotubule A narrow cylindrical tubule that runs through the center of a plasmodesma connecting two cells. The latter appears to be continuous with elements of the endoplasmic reticulum membrane of the interconnected cells. CC
GO:0008634 negative regulation of survival gene product activity Any process that stops, prevents or reduces the frequency, rate or extent of survival gene product activity; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level. BP
GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells. BP
GO:0032799 low-density lipoprotein receptor metabolic process The chemical reactions and pathways involving low-density lipoprotein receptors. BP
GO:0032798 Swi5-Sfr1 complex A conserved eukaryotic protein complex involved in DNA recombination repair; in Schizosaccharomyces the complex contains two Swi5 monomers and one Sfr1 monomer. CC
GO:0032797 SMN complex A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. CC
GO:0032796 uropod organization and biogenesis The assembly and arrangement of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated. BP
GO:0032795 heterotrimeric G-protein binding Interacting selectively with a eterotrimeric G-protein. MF
GO:0032794 GTPase activating protein binding Interacting selectively with a GTPase activating protein. MF
GO:0032793 activation of CREB transcription factor Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. BP
GO:0032792 inhibition of CREB transcription factor Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor CREB. BP
GO:0032791 lead ion binding Interacting selectively with lead (Pb) ions. MF
GO:0032790 ribosome disassembly The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. BP
GO:0043678 intine The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm. CC
GO:0008649 rRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. MF
GO:0043674 columella A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella). CC
GO:0043675 sculpture element The third layer of the sexine. CC
GO:0043676 tectum The layer of sexine which forms a roof over the columella, granules or other infratectal elements. CC
GO:0008647 low-affinity hexose transport NA BP
GO:0043670 foot layer The inner layer of the ectexine. CC
GO:0008641 small protein activating enzyme activity Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0043672 nexine The inner, non-sculptured part of the exine which lies below the sexine. CC
GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. BP
GO:0007218 neuropeptide signaling pathway The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. BP
GO:0051205 protein insertion into membrane The process by which a protein is incorporated into a biological membrane. BP
GO:0045535 negative regulation of interleukin-27 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27. BP
GO:0045534 negative regulation of interleukin-26 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26. BP
GO:0045537 positive regulation of interleukin-25 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25. BP
GO:0045536 positive regulation of interleukin-24 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24. BP
GO:0045531 regulation of interleukin-27 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27. BP
GO:0045530 regulation of interleukin-26 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26. BP
GO:0045533 negative regulation of interleukin-25 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25. BP
GO:0045532 negative regulation of interleukin-24 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24. BP
GO:0045539 positive regulation of interleukin-27 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27. BP
GO:0045538 positive regulation of interleukin-26 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26. BP
GO:0042078 germ-line stem cell division The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. BP
GO:0047009 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione. MF
GO:0047008 21-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + pregnan-21-ol = NADPH + H+ + pregnan-21-al. MF
GO:0047007 21-hydroxysteroid dehydrogenase (NAD+) activity Catalysis of the reaction: NAD+ + pregnan-21-ol = NADH + H+ + pregnan-21-al. MF
GO:0047006 20-alpha-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. MF
GO:0047005 16-alpha-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid. MF
GO:0042076 protein amino acid phosphate-linked glycosylation The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues. BP
GO:0047003 dTDP-6-deoxy-L-talose 4-dehydrogenase activity Catalysis of the reaction: NADP+ + dTDP-6-deoxy-L-talose = NADPH + dTDP-4-dehydro-6-deoxy-L-mannose. MF
GO:0047002 L-arabinitol 2-dehydrogenase activity Catalysis of the reaction: NAD+ + L-arabitol = NADH + H+ + L-ribulose. MF
GO:0047001 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate. MF
GO:0047000 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity Catalysis of the reaction: NADP+ + 2-dehydro-3-deoxy-D-gluconate = NADPH + H+ + (4S,5S)-4,5-dehydroxy-2,6-dioxohexanoate. MF
GO:0007214 gamma-aminobutyric acid signaling pathway The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. BP
GO:0051209 release of sequestered calcium ion into cytosol The process by which calcium ions sequestered in the endoplasmic reticulum or mitochondria are released into the cytosolic compartment. BP
GO:0001409 guanine nucleotide transporter activity Transports guanine nucleotides (GMP, GDP, and GTP) across membranes. MF
GO:0046758 lytic virus budding from Golgi membrane A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis. BP
GO:0046759 lytic virus budding from plasma membrane A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis. BP
GO:0046754 non-lytic viral exocytosis The exit of the virion particle from the host cell by exocytosis, without causing cell lysis. BP
GO:0046755 non-lytic virus budding A form of viral release in which the viral particles bud out through cellular membranes without causing cell lysis. It is also a form of viral envelopment. BP
GO:0046756 lytic viral exocytosis The exit of the virion particle from the host cell by exocytosis, resulting in cell lysis. BP
GO:0046757 lytic virus budding from ER membrane A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis. BP
GO:0046750 virus budding from Golgi membrane during viral capsid envelopment The envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring a membrane envelope. BP
GO:0046751 virus budding from ER membrane during viral capsid envelopment The envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring a membrane envelope. BP
GO:0046752 viral capsid precursor localization in host cell nucleus The processes by which viral capsid precursors are transported to, or maintained in, a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid. BP
GO:0046753 non-lytic viral release The release of virion particles from the cell that does not result in cell lysis. BP
GO:0005610 laminin-5 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha3, beta3 and gamma2. CC
GO:0005611 laminin-6 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha3, beta1 and gamma1. CC
GO:0005612 laminin-7 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha3, beta2 and gamma1. CC
GO:0002641 negative regulation of immunoglobulin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis. BP
GO:0002646 regulation of central tolerance induction Any process that modulates the frequency, rate, or extent of central tolerance induction. BP
GO:0005615 extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. CC
GO:0005616 larval serum protein complex A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins. CC
GO:0002645 positive regulation of tolerance induction Any process that activates or increases the frequency, rate, or extent of tolerance induction. BP
GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. CC
GO:0005619 spore wall (sensu Fungi) The specialized cell wall of the ascospore (spore). As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). CC
GO:0002648 positive regulation of central tolerance induction Any process that activates or increases the frequency, rate, or extent of central tolerance induction. BP
GO:0002649 regulation of tolerance induction to self antigen Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen. BP
GO:0002642 positive regulation of immunoglobulin biosynthetic process Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis. BP
GO:0002643 regulation of tolerance induction Any process that modulates the frequency, rate, or extent of tolerance induction. BP
GO:0002640 regulation of immunoglobulin biosynthetic process Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis. BP
GO:0005614 interstitial matrix NA CC
GO:0002647 negative regulation of central tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction. BP
GO:0002394 tolerance induction in gut-associated lymphoid tissue Tolerance induction taking place in the gut-associated lymphoid tissue (GALT). BP
GO:0002395 immune response in nasopharyngeal-associated lymphoid tissue An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids. BP
GO:0002396 MHC protein complex assembly The aggregation and bonding together of a set of components to form an MHC protein complex. BP
GO:0002397 MHC class I protein complex assembly The aggregation and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules. BP
GO:0002390 platelet activating factor production The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002391 platelet activating factor production during acute inflammatory response The synthesis or release of platelet activating factor following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002392 platelet activating factor secretion The regulated release of platelet activating factor by a cell or group of cells. BP
GO:0002393 production of lysosomal enzymes during acute inflammatory response The synthesis or release of lysosomal enzymes following a stimulus during an acute inflammatory response, resulting in an increase in intracellular or extracellular levels. BP
GO:0002398 MHC class Ib protein complex assembly The aggregation and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules. BP
GO:0002399 MHC class II protein complex assembly The aggregation and bonding together of a set of components to form an MHC class II protein complex. BP
GO:0031918 positive regulation of synaptic metaplasticity A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. BP
GO:0031919 vitamin B6 transport The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of, within or between cells. BP
GO:0031910 cytostome Stable, specialized structure for the ingestion of food by the cell into phagosomes. CC
GO:0031911 cytoproct Stable, specialized structure for extrusion of waste by the cell into the surrounding medium. CC
GO:0031912 oral apparatus Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems. CC
GO:0031913 contractile vacuole pore Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium. CC
GO:0031914 negative regulation of synaptic plasticity A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. BP
GO:0031915 positive regulation of synaptic plasticity A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. BP
GO:0031916 regulation of synaptic metaplasticity A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. BP
GO:0031917 negative regulation of synaptic metaplasticity A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. BP
GO:0004561 alpha-N-acetylglucosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. MF
GO:0004560 alpha-L-fucosidase activity Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. MF
GO:0004563 beta-N-acetylhexosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. MF
GO:0004565 beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. MF
GO:0004564 beta-fructofuranosidase activity Catalysis of the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides. MF
GO:0004567 beta-mannosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. MF
GO:0004566 beta-glucuronidase activity Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. MF
GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. MF
GO:0004568 chitinase activity Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. MF
GO:0003805 coagulation factor XIa activity Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa. MF
GO:0048176 regulation of hepatocyte growth factor biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor. BP
GO:0048177 positive regulation of hepatocyte growth factor biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor. BP
GO:0048174 negative regulation of short-term neuronal synaptic plasticity A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. BP
GO:0048175 hepatocyte growth factor biosynthetic process The chemical reactions and pathways resulting in the formation of hepacyte growth factor. Hepatocyte growth factor is a mitogen for a number of cell types and it is found in liver cells and in many other cell types, including platelets. BP
GO:0048172 regulation of short-term neuronal synaptic plasticity A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. BP
GO:0048173 positive regulation of short-term neuronal synaptic plasticity A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. BP
GO:0048170 positive regulation of long-term neuronal synaptic plasticity A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. BP
GO:0048171 negative regulation of long-term neuronal synaptic plasticity A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. BP
GO:0048178 negative regulation of hepatocyte growth factor biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor. BP
GO:0048179 activin receptor complex Activin receptors can be type I or type II and are cell surface transmembrane receptors with serine/threonine activity. CC
GO:0003939 L-iditol 2-dehydrogenase activity Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. MF
GO:0003938 IMP dehydrogenase activity Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. MF
GO:0003937 IMP cyclohydrolase activity Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. MF
GO:0003935 GTP cyclohydrolase II activity Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. MF
GO:0003934 GTP cyclohydrolase I activity Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. MF
GO:0003933 GTP cyclohydrolase activity Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. MF
GO:0050326 taxifolin 8-monooxygenase activity Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O. MF
GO:0050327 testosterone 17-beta-dehydrogenase activity Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. MF
GO:0050324 taurocyamine kinase activity Catalysis of the reaction: ATP + taurocyamine = ADP + N-phosphotaurocyamine. MF
GO:0018538 epoxide carboxylase activity NA MF
GO:0050322 taurine-2-oxoglutarate transaminase activity Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate. MF
GO:0050323 taurine dehydrogenase activity Catalysis of the reaction: taurine + H2O + acceptor = sulfoacetaldehyde + NH3 + reduced acceptor. MF
GO:0050320 tartrate epimerase activity Catalysis of the reaction: (R,R)-tartrate = meso-tartrate. MF
GO:0050321 tau-protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. MF
GO:0018533 peptidyl-cysteine acetylation The acetylation of peptidyl-cysteine. BP
GO:0018532 F433-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin. MF
GO:0018531 (S)-6-hydroxynicotine oxidase activity Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2. MF
GO:0018530 (R)-6-hydroxynicotine oxidase activity Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2. MF
GO:0018537 coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity Catalysis of the reaction: N5,N10-methylenetetrahydromethanopterin + reduced coenzyme F420 = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme F420. MF
GO:0018535 nicotine dehydrogenase activity Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor. MF
GO:0018534 nitrilotriacetate dehydrogenase activity Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate. MF
GO:0051747 DNA demethylase activity Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA. MF
GO:0051746 thalianol synthase activity Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol). MF
GO:0007139 meiotic telophase II Progression through telophase of meiosis II; analogous to mitotic telophase. BP
GO:0007138 meiotic anaphase II Progression through anaphase of meiosis II; analogous to mitotic anaphase. BP
GO:0051743 red chlorophyll catabolite reductase activity Catalysis of the reaction: red chlorophyll catabolite (RCC) + reduced ferredoxin + 2 H+ = primary fluorescent catabolite (pFCC) + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite to a colorless tetrapyrrole with a strong blue fluorescence. MF
GO:0051742 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine. MF
GO:0051741 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine. MF
GO:0051740 ethylene binding Interacting selectively with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. MF
GO:0007133 meiotic anaphase I Progression through anaphase of meiosis I; analogous to mitotic anaphase. BP
GO:0007132 meiotic metaphase I Progression through metaphase of meiosis I; analogous to mitotic metaphase. BP
GO:0007131 meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. BP
GO:0007130 synaptonemal complex formation The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination. BP
GO:0007137 meiotic metaphase II Progression through metaphase of meiosis II; analogous to mitotic metaphase. BP
GO:0007136 meiotic prophase II Progression through prophase of meiosis II; analogous to mitotic prophase. BP
GO:0007135 meiosis II Progression through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome. BP
GO:0051748 UDP-sugar pyrophosphorylase activity Catalysis of the reaction: monosaccharide 1-phosphate + UTP = UDP-sugar + pyrophosphate. MF
GO:0052214 metabolism of substance in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052215 energy taxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052216 chemotaxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052217 aerotaxis in environment of other organism during symbiotic interaction The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052210 interaction with other organism via protein secreted by type III secretion system during symbiotic interaction An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction. BP
GO:0052211 interaction with other organism via protein secreted by type II secretion system during symbiotic interaction An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction. BP
GO:0052212 modification of morphology or physiology of other organism via secreted substance during symbiotic interaction The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction. BP
GO:0052213 interaction with symbiont via secreted substance An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052218 positive energy taxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052219 negative energy taxis in environment of other organism during symbiotic interaction The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0010150 leaf senescence The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism. BP
GO:0017091 AU-specific RNA binding Interacting selectively with AU-rich elements within the 3' untranslated region of mRNAs. MF
GO:0017090 meprin A complex An enzyme complex that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues. CC
GO:0010152 pollen maturation The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains. BP
GO:0005018 platelet-derived growth factor alpha-receptor activity NA MF
GO:0032807 DNA ligase IV complex A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif4p. CC
GO:0032806 carboxy-terminal domain protein kinase complex A protein complex that phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats; in Saccharomyces the complex contains Ctk1p, Ctk2p, and Ctk3p. CC
GO:0032805 positive regulation of low-density lipoprotein receptor catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors. BP
GO:0032804 negative regulation of low-density lipoprotein receptor catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors. BP
GO:0032803 regulation of low-density lipoprotein receptor catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors. BP
GO:0032802 low-density lipoprotein receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. BP
GO:0032801 receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. BP
GO:0032800 receptor biosynthetic process The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. BP
GO:0032809 cell soma membrane The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. CC
GO:0032808 lacrimal gland development The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. BP
GO:0015453 oxidoreduction-driven active transporter activity Catalysis of the transport of a solute, driven by the exothermic flow of electrons from a reduced substrate to an oxidized substrate. MF
GO:0015452 methyl transfer-driven active transporter activity Catalysis of the transport of a solute, driven by a methyl transfer reaction. MF
GO:0015451 decarboxylation-driven active transporter activity Catalysis of the transport of a solute, driven by the decarboxylation of a cytoplasmic substrate. MF
GO:0015450 protein translocase activity NA MF
GO:0015457 auxiliary transport protein activity Facilitates transport across one or more biological membranes but do not themselves participate directly in transport. These proteins always function in conjunction with one or more established transport systems. They may provide a function connected with energy coupling to transport, play a structural role in complex formation, serve a biogenic or stability function or function in regulation. MF
GO:0015455 group translocator activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. MF
GO:0015454 light-driven active transporter activity Catalysis of the transport of a solute, driven by light energy. MF
GO:0015459 potassium channel regulator activity NA MF
GO:0015458 low voltage-gated potassium channel auxiliary protein activity NA MF
GO:0047577 4-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH + H+. MF
GO:0047576 4-chlorobenzoate dehalogenase activity Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride. MF
GO:0047575 4-carboxymuconolactone decarboxylase activity Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2. MF
GO:0047574 4-acetamidobutyryl-CoA deacetylase activity Catalysis of the reaction: 4-acetamidobutanoyl + H2O = acetate + 4-aminobutanoyl-CoA. MF
GO:0047573 4-acetamidobutyrate deacetylase activity Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate. MF
GO:0047572 3-phosphoglycerate phosphatase activity Catalysis of the reaction: D-glycerate 3-phosphate + H2O = D-glycerate + phosphate. MF
GO:0047571 3-oxosteroid 1-dehydrogenase activity Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor. MF
GO:0047570 3-oxoadipate enol-lactonase activity Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. MF
GO:0047579 4-hydroxymandelate oxidase activity Catalysis of the reaction: (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2. MF
GO:0047578 4-hydroxyglutamate transaminase activity Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate. MF
GO:0043267 negative regulation of potassium ion transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells. BP
GO:0043266 regulation of potassium ion transport Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells. BP
GO:0021988 olfactory lobe development The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. BP
GO:0043264 extracellular non-membrane-bound organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. CC
GO:0043263 cellulosome An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose. CC
GO:0043262 adenosine-diphosphatase activity Catalysis of the reaction: ADP + H2O = AMP + phosphate. MF
GO:0043261 laminin-12 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma3. CC
GO:0043260 laminin-11 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha5, beta2 and gamma1. CC
GO:0021982 pineal gland development The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms. BP
GO:0021983 pituitary gland development The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. BP
GO:0021980 subpallium cell migration The orderly movement of cells from one site to another in the subpallium. BP
GO:0021981 subpallium radially oriented migration The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. BP
GO:0021986 habenula development The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland. BP
GO:0021987 cerebral cortex development The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. BP
GO:0021984 adenohypophysis development The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. BP
GO:0021985 neurohypophysis development The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. BP
GO:0005116 saxophone binding Interacting selectively with the saxophone (sax) protein, a type I transforming growth factor beta receptor. MF
GO:0046224 bacteriocin metabolic process The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. BP
GO:0046225 bacteriocin catabolic process The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. BP
GO:0046226 coumarin catabolic process The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. BP
GO:0046220 pyridine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. BP
GO:0046221 pyridine catabolic process The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor. BP
GO:0046222 aflatoxin metabolic process The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. BP
GO:0046223 aflatoxin catabolic process The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. BP
GO:0046228 2,4,5-trichlorophenoxyacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide. BP
GO:0005113 patched binding Interacting selectively with the patched (ptc) protein, a receptor for hedgehog proteins. MF
GO:0030519 snoRNP binding Interacting selectively with a protein constituent of a small nucleolar ribonucleoprotein particle. MF
GO:0030518 steroid hormone receptor signaling pathway Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor. BP
GO:0030517 negative regulation of axon extension Any process that stops, prevents or reduces the frequency, rate or extent of axon outgrowth. BP
GO:0030516 regulation of axon extension Any process that modulates the rate, direction or extent of axon extension. BP
GO:0030515 snoRNA binding Interacting selectively with small nucleolar RNA. MF
GO:0030514 negative regulation of BMP signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway activity. BP
GO:0030513 positive regulation of BMP signaling pathway Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. BP
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of any TGFbeta receptor signaling pathway. BP
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway Any process that activates or increases the frequency, rate or extent of TGFbeta receptor signaling pathway activity. BP
GO:0030510 regulation of BMP signaling pathway Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. BP
GO:0002017 aldosterone mediated regulation of body fluids The process by which the hormone aldosterone decreases the rate of diuresis and natriuresis. BP
GO:0015637 peptide uptake permease activity NA MF
GO:0047468 phosphoglucomutase (glucose-cofactor) activity Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate. MF
GO:0002016 renin-angiotensin regulation of body fluid levels The process by which the renin-angiotensin system controls the rate of diuresis and natriuresis. BP
GO:0047467 4-hydroxyphenylacetaldehyde-oxime isomerase activity Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime. MF
GO:0047466 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity Catalysis of the reaction: cis-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide. MF
GO:0031648 protein destabilization Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. BP
GO:0031649 heat generation Any process by which an organism produces heat, thereby raising its internal temperature. BP
GO:0031644 regulation of neurological process Any process that modulates the frequency, rate or extent of a neurophysiological process. BP
GO:0031645 negative regulation of neurological process Any process that stops, prevents or reduces the frequency, rate or extent of a neurophysiological process. BP
GO:0031646 positive regulation of neurological process Any process that activates or increases the frequency, rate or extent of a neurophysiological process. BP
GO:0031647 regulation of protein stability Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation. BP
GO:0031640 killing of cells of another organism Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. BP
GO:0031641 regulation of myelination Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. BP
GO:0031642 negative regulation of myelination Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons. BP
GO:0031643 positive regulation of myelination Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. BP
GO:0009496 plastoquinol-plastocyanin reductase activity Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. MF
GO:0002011 morphogenesis of an epithelial sheet The process by which the anatomical structures of an epithelial sheet are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0002862 negative regulation of inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. BP
GO:0002863 positive regulation of inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. BP
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. BP
GO:0002861 regulation of inflammatory response to antigenic stimulus Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. BP
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. BP
GO:0002867 regulation of B cell deletion Any process that modulates the frequency, rate, or extent of B cell deletion. BP
GO:0002864 regulation of acute inflammatory response to antigenic stimulus Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. BP
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. BP
GO:0002868 negative regulation of B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion. BP
GO:0002869 positive regulation of B cell deletion Any process that activates or increases the frequency, rate, or extent of B cell deletion. BP
GO:0032340 positive regulation of inhibin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells. BP
GO:0032341 aldosterone metabolic process The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. BP
GO:0032342 aldosterone biosynthetic process The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. BP
GO:0032343 aldosterone catabolic process The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. BP
GO:0032344 regulation of aldosterone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. BP
GO:0009729 detection of brassinosteroid stimulus The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal. BP
GO:0032346 positive regulation of aldosterone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. BP
GO:0032347 regulation of aldosterone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. BP
GO:0009724 detection of abscisic acid stimulus The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal. BP
GO:0032349 positive regulation of aldosterone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. BP
GO:0009726 detection of endogenous stimulus The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal. BP
GO:0009727 detection of ethylene stimulus The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal. BP
GO:0009720 detection of hormone stimulus The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal. BP
GO:0009721 detection of auxin stimulus The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal. BP
GO:0009722 detection of cytokinin stimulus The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal. BP
GO:0009723 response to ethylene stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. BP
GO:0019970 interleukin-11 binding Interacting selectively with interleukin-11. MF
GO:0019972 interleukin-12 binding Interacting selectively with interleukin-12. MF
GO:0019973 interleukin-13 binding Interacting selectively with interleukin-13. MF
GO:0019974 interleukin-14 binding Interacting selectively with interleukin-14. MF
GO:0019975 interleukin-17 binding Interacting selectively with interleukin-17. MF
GO:0019976 interleukin-2 binding Interacting selectively with interleukin-2. MF
GO:0019977 interleukin-21 binding Interacting selectively with interleukin-21. MF
GO:0019978 interleukin-3 binding Interacting selectively with interleukin-3. MF
GO:0019979 interleukin-4 binding Interacting selectively with interleukin-4. MF
GO:0002350 peripheral B cell positive selection Any process leading to positive selection of B cells in the periphery. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors. BP
GO:0031701 angiotensin receptor binding Interacting selectively with an angiotensin receptor. MF
GO:0031700 adrenomedullin receptor binding Interacting selectively with an adrenomedullin receptor. MF
GO:0047935 glucose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,4-lactone + NADPH. MF
GO:0031702 type 1 angiotensin receptor binding Interacting selectively with a type 1 angiotensin receptor. MF
GO:0031705 bombesin receptor binding Interacting selectively with a bombesin receptor. MF
GO:0031704 apelin receptor binding Interacting selectively with an apelin receptor. MF
GO:0047931 glucosamine kinase activity Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate. MF
GO:0031706 subtype 3 bombesin receptor binding Interacting selectively with a subtype 3 bombesin receptor. MF
GO:0045708 regulation of larval salivary gland determination Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism. BP
GO:0045709 negative regulation of adult salivary gland determination Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination in an adult organism. BP
GO:0045702 positive regulation of spermatid nuclear differentiation Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation. BP
GO:0045703 ketoreductase activity Catalysis of the reduction of a ketone group to form the corresponding alcohol. MF
GO:0045700 regulation of spermatid nuclear differentiation Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation. BP
GO:0045701 negative regulation of spermatid nuclear differentiation Any process that stops, prevents or reduces the frequency, rate or extent of spermatid nuclear differentiation. BP
GO:0045706 positive regulation of salivary gland determination Any process that activates or increases the frequency, rate or extent of salivary gland determination. BP
GO:0045707 regulation of adult salivary gland determination Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism. BP
GO:0045704 regulation of salivary gland determination Any process that modulates the frequency, rate or extent of salivary gland determination. BP
GO:0045705 negative regulation of salivary gland determination Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination. BP
GO:0047638 albendazole monooxygenase activity Catalysis of the reaction: albendazole + NADPH + O2 = albendazole S-oxide + NADP+ + H2O. MF
GO:0047639 alcohol oxidase activity Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2. MF
GO:0047634 agmatine N4-coumaroyltransferase activity Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = CoA + N-(4-guanidinobutyl)-N4-hydroxycinnamamide. MF
GO:0047635 alanine-oxo-acid transaminase activity Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid. MF
GO:0047636 alanopine dehydrogenase activity Catalysis of the reaction: 2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH. MF
GO:0047637 alanylphosphatidylglycerol synthase activity Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol. MF
GO:0047630 ADP-phosphoglycerate phosphatase activity Catalysis of the reaction: 3-(ADP)-2-phosphoglycerate + H2O = 3-(ADP)-glycerate + phosphate. MF
GO:0047631 ADP-ribose diphosphatase activity Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. MF
GO:0047632 agmatine deiminase activity Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3. MF
GO:0047633 agmatine kinase activity Catalysis of the reaction: ATP + agmatine = ADP + N4-phosphoagmatine. MF
GO:0006570 tyrosine metabolic process The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. BP
GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. BP
GO:0006572 tyrosine catabolic process The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. BP
GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. BP
GO:0006574 valine catabolic process The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. BP
GO:0006575 amino acid derivative metabolic process The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. BP
GO:0006576 biogenic amine metabolic process The chemical reactions and pathways involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. BP
GO:0006577 betaine metabolic process The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. BP
GO:0006578 betaine biosynthetic process The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid. BP
GO:0006579 betaine catabolic process The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid. BP
GO:0002053 positive regulation of mesenchymal cell proliferation The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. BP
GO:0002052 positive regulation of neuroblast proliferation Any process that activates or increases the rate of neuroblast proliferation. BP
GO:0002051 osteoblast fate commitment The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. BP
GO:0048812 neurite morphogenesis The process by which the anatomical structures of neurites are generated and organized. Morphogenesis pertains to the creation of form. A neurite is any process extending from a neural cell, such as axons or dendrites. BP
GO:0002057 guanine binding Interacting selectively with guanine. MF
GO:0002056 cytosine binding Interactiing selectively with cytosine. MF
GO:0005007 fibroblast growth factor receptor activity Combining with fibroblast growth factor to initiate a change in cell activity. MF
GO:0002054 nucleobase binding Interacting selectively with an nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. MF
GO:0048819 regulation of hair follicle maturation Any process that modulates the frequency, rate or extent of hair follicle maturation. BP
GO:0005008 hepatocyte growth factor receptor activity Combining with hepatocye growth factor to initiate a change in cell activity. MF
GO:0002059 thymine binding Interacting selectively with thymine. MF
GO:0002058 uracil binding Interacting selectively with uracil. MF
GO:0051127 positive regulation of actin nucleation Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. BP
GO:0051126 negative regulation of actin nucleation Any process that stops, prevents or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. BP
GO:0051125 regulation of actin nucleation Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. BP
GO:0051124 synaptic growth at neuromuscular junction The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates. BP
GO:0051123 transcriptional preinitiation complex formation The assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the RNA polymerase II promoter. BP
GO:0051122 hepoxilin biosynthetic process The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. BP
GO:0051121 hepoxilin metabolic process The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology. BP
GO:0051120 hepoxilin A3 synthase activity Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid [12S-HpETE] = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate [hepoxilin A3]. MF
GO:0051129 negative regulation of cell organization and biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of the processes involved in the assembly and arrangement of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. BP
GO:0051128 regulation of cell organization and biogenesis Any process that modulates the frequency, rate or extent of the processes involved in the assembly and arrangement of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. BP
GO:0010007 magnesium chelatase complex A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner. CC
GO:0010006 Toc complex Protein translocon complex at the chloroplast outer membrane. CC
GO:0010005 cortical microtubule (sensu Viridiplantae) Arrays of microtubules underlying and connected to the plasma membrane of plant cells, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell(and root). It influences the direction of cellulose microfibril deposition. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0010004 gastrulation (sensu Insecta) The process of gastrulation; as in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0010003 gastrulation (sensu Mammalia) The process of gastrulation, as in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674). BP
GO:0010002 cardioblast differentiation The process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. BP
GO:0010001 glial cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell. BP
GO:0010000 negative regulation of cone cell fate specification (sensu Endopterygota) Any process that restricts, stops or prevents a cell from specifying into a cone cell. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0010009 external side of endosome membrane The external (cytoplasmic face) of an endosome membrane. CC
GO:0010008 endosome membrane The lipid bilayer surrounding an endosome. CC
GO:0001650 fibrillar center A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. CC
GO:0001651 dense fibrillar component A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins. CC
GO:0001652 granular component A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm. CC
GO:0001653 peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity. MF
GO:0001654 eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. BP
GO:0001655 urogenital system development The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. BP
GO:0001656 metanephros development The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is the excretory organ of the fetus which develops into the kidney and is formed from the rear portion of the nephrogenic cord. BP
GO:0001657 ureteric bud development The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. BP
GO:0001658 ureteric bud branching Branching of the ureteric bud. BP
GO:0001659 thermoregulation The processes by which an organism modulates its internal body temperature. BP
GO:0043601 replisome (sensu Eukaryota) A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0003878 ATP citrate synthase activity Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. MF
GO:0003879 ATP phosphoribosyltransferase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0052470 modulation by host of symbiont signal transduction pathway Any process by which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052472 modulation by host of symbiont transcription Any process by which an organism modulates the frequency, rate or extent of symbiont transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0003872 6-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. MF
GO:0003873 6-phosphofructo-2-kinase activity Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate. MF
GO:0003870 5-aminolevulinate synthase activity Catalysis of the reaction: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2. MF
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. MF
GO:0003876 AMP deaminase activity Catalysis of the reaction: AMP + H2O = IMP + NH3. MF
GO:0003877 ATP adenylyltransferase activity Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. MF
GO:0003874 6-pyruvoyltetrahydropterin synthase activity Catalysis of the reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate. MF
GO:0003875 ADP-ribosylarginine hydrolase activity Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. MF
GO:0019569 L-arabinose catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate. BP
GO:0019568 arabinose catabolic process The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose. BP
GO:0019563 glycerol catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. BP
GO:0019562 phenylalanine catabolic process to phosphoenolpyruvate The chemical reactions and pathways resulting in the breakdown of phenylalanine into other compounds, including phosphoenolpyruvate. BP
GO:0019561 anaerobic phenylalanine oxidation NA BP
GO:0019560 histidine catabolic process to hydantoin-5-propionate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate. BP
GO:0019567 arabinose biosynthetic process The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose. BP
GO:0019566 arabinose metabolic process The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides. BP
GO:0019564 aerobic glycerol catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen. BP
GO:0042949 arbutin transport The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of, within or between cells. BP
GO:0004069 aspartate transaminase activity Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. MF
GO:0050325 tauropine dehydrogenase activity Catalysis of the reaction: tauropine + NAD+ + H2O = taurine + pyruvate + NADH. MF
GO:0042941 D-alanine transport The directed movement of D-alanine, the dextrorotatory isomer of 2-aminopropanoic acid, into, out of, within or between cells. BP
GO:0004061 arylformamidase activity Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. MF
GO:0042943 D-amino acid transporter activity Enables the directed movement of the dextrorotatory isomer of amino acids into, out of, within or between cells. MF
GO:0042942 D-serine transport The directed movement of D-serine, the dextrorotatory isomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells. BP
GO:0042945 D-serine transporter activity Enables the directed movement of D-serine, the dextrorotatory isomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells. MF
GO:0042944 D-alanine transporter activity Enables the directed movement of D-alanine, the dextrorotatory isomer of 2-aminopropanoic acid, into, out of, within or between cells. MF
GO:0042947 glucoside transporter activity Enables the directed movement of glucosides into, out of, within or between cells. Glucosides are glycosides in which the sugar moiety is a glucose residue. MF
GO:0042946 glucoside transport The directed movement of glucosides into, out of, within or between cells. Glucosides are glycosides in which the sugar moiety is a glucose residue. BP
GO:0019698 D-galacturonate catabolic process The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the dextrorotatory isomer of galacturonate, the anion of galacturonic acid. BP
GO:0019695 choline metabolic process The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. BP
GO:0019694 alkanesulfonate metabolic process The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety. BP
GO:0019697 L-xylitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. BP
GO:0019696 toluene oxidation via toluene-cis-1,2-dihydrodiol The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol. BP
GO:0019691 UDP-glucose conversion NA BP
GO:0019690 pyrimidine deoxyribonucleoside interconversion NA BP
GO:0019693 ribose phosphate metabolic process The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar. BP
GO:0019692 deoxyribose phosphate metabolic process The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. BP
GO:0050328 tetrahydroberberine oxidase activity Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2. MF
GO:0050329 tetrahydroxypteridine cycloisomerase activity Catalysis of the reaction: tetrahydroxypteridine = xanthine-8-carboxylate. MF
GO:0048729 tissue morphogenesis The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048728 proboscis development The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure. BP
GO:0048727 posterior cibarial plate development The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure. BP
GO:0048726 labrum development The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure. BP
GO:0005115 receptor tyrosine kinase-like orphan receptor binding Interaction with the receptor tyrosine kinase-like orphan receptor (Ror). MF
GO:0051462 regulation of cortisol secretion Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells. BP
GO:0051463 negative regulation of cortisol secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells. BP
GO:0005821 intermediate layer of spindle pole body Structure between the central and outer plaques of the spindle pole body. CC
GO:0048724 epistomal sclerite development The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure. BP
GO:0051466 positive regulation of corticotropin-releasing hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells. BP
GO:0005826 contractile ring A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis. CC
GO:0051464 positive regulation of cortisol secretion Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells. BP
GO:0051465 negative regulation of corticotropin-releasing hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells. BP
GO:0048723 clypeus development The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head. BP
GO:0051468 detection of glucocorticoid hormone stimulus The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. BP
GO:0051469 vesicle fusion with vacuole The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. BP
GO:0002324 natural killer cell proliferation during immune response The rapid expansion of a natural killer cell population by cell division during an immune response. BP
GO:0005111 type 2 fibroblast growth factor receptor binding Interacting selectively with the type 2 fibroblast growth factor receptor (FGFR2). MF
GO:0005110 frizzled-2 binding Interacting selectively with frizzled-2 (fz2). MF
GO:0015857 uracil transport The directed movement of uracil, 2,4-dioxopyrimidine, into, out of, within or between cells. BP
GO:0015856 cytosine transport The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of, within or between cells. BP
GO:0015855 pyrimidine transport The directed movement of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells. BP
GO:0015854 guanine transport The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of, within or between cells. BP
GO:0015853 adenine transport The directed movement of adenine, 6-aminopurine, into, out of, within or between cells. BP
GO:0015851 nucleobase transport The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of, within or between cells. BP
GO:0015850 organic alcohol transport The directed movement of organic alcohols into, out of, within or between cells. An organic alcohol is any carbon-containing compound containing a hydroxyl group. BP
GO:0015859 intracellular nucleoside transport The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell. BP
GO:0015858 nucleoside transport The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of, within or between cells. BP
GO:0004248 stromelysin 1 activity Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues. MF
GO:0004249 stromelysin 3 activity NA MF
GO:0004244 mitochondrial inner membrane peptidase activity Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space. MF
GO:0004246 peptidyl-dipeptidase A activity Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II. MF
GO:0051076 Gram-positive bacterial binding Interacting selectively with any part of a Gram-positive bacterial cell. MF
GO:0051071 4,6-pyruvylated galactose residue metabolic process The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. BP
GO:0004243 mitochondrial intermediate peptidase activity Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion. MF
GO:0008967 phosphoglycolate phosphatase activity Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. MF
GO:0006039 cell wall chitin catabolic process The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells. BP
GO:0006038 cell wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells. BP
GO:0006031 chitin biosynthetic process The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. BP
GO:0006030 chitin metabolic process The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. BP
GO:0006033 chitin localization The processes by which chitin is transported to, or maintained in, a specific location. BP
GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. BP
GO:0006035 cuticle chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles. BP
GO:0006034 cuticle chitin metabolic process The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles. BP
GO:0006037 cell wall chitin metabolic process The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells. BP
GO:0006036 cuticle chitin catabolic process The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles. BP
GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. BP
GO:0008036 diuretic hormone receptor activity Combining with a diuretic hormone to initiate a change in cell activity. MF
GO:0008035 high-density lipoprotein binding Interacting selectively with high-density lipoprotein: one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans). MF
GO:0008034 lipoprotein binding Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. MF
GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. BP
GO:0008031 eclosion hormone activity NA MF
GO:0008030 neuronal pentraxin receptor activity NA MF
GO:0008039 synaptic target recognition The process by which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses. BP
GO:0008038 neuron recognition The process by which a neuronal cell in a multicellular organism interprets its surroundings. BP
GO:0014069 postsynaptic density The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. CC
GO:0014068 positive regulation of phosphoinositide 3-kinase cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. BP
GO:0014065 phosphoinositide 3-kinase cascade A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions. BP
GO:0014064 positive regulation of serotonin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. BP
GO:0014067 negative regulation of phosphoinositide 3-kinase cascade Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. BP
GO:0014066 regulation of phosphoinositide 3-kinase cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. BP
GO:0014061 regulation of norepinephrine secretion Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. BP
GO:0014060 regulation of epinephrine secretion Any process that modulates the frequency, rate or extent of the regulated release of epinephrine. BP
GO:0014063 negative regulation of serotonin secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of serotonin. BP
GO:0014062 regulation of serotonin secretion Any process that modulates the frequency, rate or extent of the regulated release of serotonin. BP
GO:0051745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. MF
GO:0051744 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+. MF
GO:0048856 anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. BP
GO:0044011 single-species biofilm formation on inanimate substrate A process whereby microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. BP
GO:0044010 single-species biofilm formation A process whereby microorganisms of the same species attach to and grow on a surface such, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. BP
GO:0015084 aluminum resistance permease activity NA MF
GO:0015085 calcium ion transporter activity Enables the directed movement of calcium (Ca) ions into, out of, within or between cells. MF
GO:0015086 cadmium ion transporter activity Enables the directed movement of cadmium (Cd) ions into, out of, within or between cells. MF
GO:0015087 cobalt ion transporter activity Enables the directed movement of cobalt (Co) ions into, out of, within or between cells. MF
GO:0015080 silver ion transporter activity Enables the directed movement of silver (Ag) ions into, out of, within or between cells. MF
GO:0015081 sodium ion transporter activity Enables the directed movement of sodium ions (Na+) into, out of, within or between cells. MF
GO:0015082 di-, tri-valent inorganic cation transporter activity Enables the directed movement of inorganic cations with a valency of two or three into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. MF
GO:0015083 aluminum ion transporter activity Enables the directed movement of aluminum (Al) ions into, out of, within or between cells. MF
GO:0015088 copper uptake transporter activity Catalysis of the reaction: Cu+(out) = Cu+(in). MF
GO:0015089 high affinity copper ion transporter activity Catalysis of the reaction: Cu2+(out) = Cu2+(in). MF
GO:0051749 indole acetic acid carboxyl methyltransferase activity Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine. MF
GO:0007134 meiotic telophase I Progression through telophase of meiosis I; analogous to mitotic telophase. BP
GO:0047432 2,2-dialkylglycine decarboxylase (pyruvate) activity Catalysis of the reaction: 2,2-dialkylglycine + pyruvate = dialkyl ketone + L-alanine + CO2. MF
GO:0047433 branched-chain-2-oxoacid decarboxylase activity Catalysis of the reaction: (3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2. MF
GO:0047430 oligosaccharide-diphosphodolichol diphosphatase activity Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate. MF
GO:0047431 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity Catalysis of the reaction: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate = CO2 + 3-hydroxy-2-methylpyridine-5-carboxylate. MF
GO:0047436 arylmalonate decarboxylase activity Catalysis of the reaction: 2-aryl-2-methylmalonate = CO2 + 2-arylpropionate. MF
GO:0047437 4-oxalocrotonate decarboxylase activity Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate. MF
GO:0047434 indolepyruvate decarboxylase activity Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde. MF
GO:0047435 5-guanidino-2-oxopentanoate decarboxylase activity Catalysis of the reaction: 5-guanidino-2-oxo-pentanoate = CO2 + 4-guanidinobutanoate. MF
GO:0047438 2-dehydro-3-deoxy-L-pentonate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate. MF
GO:0047439 3-deoxy-D-manno-octulosonate aldolase activity Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate. MF
GO:0043542 endothelial cell migration The orderly movement of endothelial cells into the extracellular matrix to form an endothelium. BP
GO:0043543 protein amino acid acylation The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. BP
GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis. CC
GO:0043541 UDP-N-acetylglucosamine transferase complex A heterooligomeric complex that in yeast is composed of a catalytic subunit, Alg13p, and an anchoring subunit, Alg14p. Catalyses the second step of dolichyl-linked oligosaccharide synthesis of GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc. CC
GO:0043546 molybdopterin cofactor binding Interacting selectively with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. MF
GO:0043547 positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. BP
GO:0043544 lipoamide binding Interacting selectively with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group. MF
GO:0043545 molybdopterin cofactor metabolic process The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. BP
GO:0043548 phosphoinositide 3-kinase binding Interacting selectively with a phosphoinositide 3-kinase, any enzyme that catalyses the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. MF
GO:0043549 regulation of kinase activity Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. BP
GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. BP
GO:0016574 histone ubiquitination The modification of histones by addition of ubiquitin groups. BP
GO:0016577 histone demethylation The modification of histones by removal of methyl groups. BP
GO:0016576 histone dephosphorylation The modification of histones by removal of phosphoric groups. BP
GO:0016571 histone methylation The modification of histones by addition of methyl groups. BP
GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. BP
GO:0016573 histone acetylation The modification of histones by addition of acetyl groups. BP
GO:0016572 histone phosphorylation The modification of histones by addition of phosphoric groups. BP
GO:0016579 protein deubiquitination The removal of one or more ubiquitin moieties from a protein. BP
GO:0016578 histone deubiquitination The modification of histones by removal of ubiquitin groups. BP
GO:0046529 imaginal disc fusion, thorax closure The joining of the parts of the wing imaginal discs, giving rise to the adult thorax. BP
GO:0046528 imaginal disc fusion The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis. BP
GO:0045874 positive regulation of sevenless signaling pathway Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway. BP
GO:0045875 negative regulation of sister chromatid cohesion Any process that stops, prevents or reduces the frequency, rate or extent of sister chromatid cohesion. BP
GO:0045876 positive regulation of sister chromatid cohesion Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion. BP
GO:0045877 negative regulation of smoothened activity Any process that stops, prevents or reduces the activity of the transmembrane protein Smoothened. BP
GO:0045870 positive regulation of retroviral genome replication Any process that activates or increases the frequency, rate or extent of retroviral genome replication. BP
GO:0045871 negative regulation of rhodopsin gene activity Any process that stops, prevents or reduces the frequency, rate or extent of rhodopsin gene activity. BP
GO:0045872 positive regulation of rhodopsin gene activity Any process that activates or increases the frequency, rate or extent of rhodopsin gene activity. BP
GO:0045873 negative regulation of sevenless signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the sevenless signaling pathway. BP
GO:0045878 positive regulation of smoothened activity Any process that activates or increases the activity of the transmembrane protein Smoothened. BP
GO:0045879 negative regulation of smoothened signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling. BP
GO:0043094 metabolic compound salvage Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis. BP
GO:0043095 regulation of GTP cyclohydrolase I activity Any process that modulates the activity of the enzyme GTP cyclohydrolase I. BP
GO:0043096 purine base salvage Any process that generates purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis. BP
GO:0043097 pyrimidine nucleoside salvage Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. BP
GO:0043090 amino acid import The directed movement of amino acids into a cell or organelle. BP
GO:0043091 L-arginine import The directed movement of L-arginine, the levorotatory isomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle. BP
GO:0043092 L-amino acid import The directed movement of levorotatory isomer amino acids into a cell or organelle. BP
GO:0043093 binary fission A process in which two similarly sized and shaped cells are formed by the division of one cell, the process by which most bacteria reproduce. BP
GO:0043098 purine deoxyribonucleoside salvage Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis. BP
GO:0043099 pyrimidine deoxyribonucleoside salvage Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis. BP
GO:0046383 dTDP-rhamnose metabolic process The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. BP
GO:0046382 GDP-D-rhamnose metabolic process The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate. BP
GO:0046381 CMP-N-acetylneuraminate metabolic process The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate. BP
GO:0046380 N-acetylneuraminate biosynthetic process The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. BP
GO:0046387 deoxyribose 1,5-bisphosphate metabolic process The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose. BP
GO:0046386 deoxyribose phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. BP
GO:0046385 deoxyribose phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. BP
GO:0046384 2-deoxyribose 1-phosphate metabolic process The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. BP
GO:0046389 deoxyribose 5-phosphate metabolic process The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose. BP
GO:0046388 deoxyribose 1-phosphate metabolic process The chemical reactions and pathways involving deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose. BP
GO:0030492 hemoglobin binding Interacting selectively with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. MF
GO:0030493 bacteriochlorophyll metabolic process The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. BP
GO:0030490 processing of 20S pre-rRNA NA BP
GO:0030491 heteroduplex formation The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. BP
GO:0030496 midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. CC
GO:0030497 fatty acid elongation The elongation of a fatty acid chain by the sequential addition of two-carbon units. BP
GO:0030494 bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. BP
GO:0030495 bacteriochlorophyll catabolic process The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. BP
GO:0009029 tetraacyldisaccharide 4'-kinase activity Catalysis of the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. MF
GO:0009028 tartronate-semialdehyde synthase activity Catalysis of the reaction: 2 glyoxylate = tartronate semialdehyde + CO2. MF
GO:0009027 tartrate dehydrogenase activity Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+. MF
GO:0009026 tagaturonate reductase activity Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + NADH + H+. MF
GO:0009025 tagatose-bisphosphate aldolase activity Catalysis of the reaction: D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. MF
GO:0009024 tagatose-6-phosphate kinase activity Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. MF
GO:0009022 tRNA nucleotidyltransferase activity Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. MF
GO:0009021 tRNA (uracil-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine. MF
GO:0009020 tRNA (guanosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine. MF
GO:0008990 rRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. MF
GO:0008991 serine-type signal peptidase activity Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism. MF
GO:0008992 repressor LexA activity Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA. MF
GO:0008993 rhamnulokinase activity Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate. MF
GO:0008994 rhamnulose-1-phosphate aldolase activity Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. MF
GO:0008995 ribonuclease E activity Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. MF
GO:0008996 ribonuclease G activity Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. MF
GO:0008997 ribonuclease R activity Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides. MF
GO:0008998 ribonucleoside-triphosphate reductase activity Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin. MF
GO:0008999 ribosomal-protein-alanine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine. MF
GO:0030726 testicular ring canal formation Formation of the intercellular bridges that connect the germ-line cells of a male cyst. BP
GO:0030727 female germ-line cyst formation (sensu Insecta) Formation of a cluster of germ-line cells, in the female gonad, derived from a single founder cell (cystoblast). As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0030720 oocyte localization during oogenesis Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. BP
GO:0030721 spectrosome organization and biogenesis The assembly and arrangement of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome. BP
GO:0030722 establishment of oocyte nucleus localization during oocyte axis determination The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the axes of the oocyte. BP
GO:0030723 ovarian fusome organization and biogenesis The assembly and arrangement of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions. BP
GO:0045128 negative regulation of meiotic recombination Any process that stops, prevents or reduces the frequency, rate or extent of recombination during meiosis. BP
GO:0045129 NAD-independent histone deacetylase activity Catalysis of the removal of acetyl groups from histones, independently of NAD. MF
GO:0045122 aflatoxin biosynthetic process The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. BP
GO:0045123 cellular extravasation The migration of leukocytes from the blood vessels into the surrounding tissue. BP
GO:0045120 pronucleus The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. CC
GO:0045121 lipid raft Specialized membrane domains composed mainly of cholesterol and sphingolipids, and are relatively poor in polyunsaturated lipids such as glycerophospholipids. The formation of these membrane domains is promoted by the presence of cholesterol in the lipid bilayer: the rigid hexagonal rings of cholesterol can pack tightly against the saturated hydrocarbon chains of some membrane lipids, allowing these lipids to assemble into cohesive units floating in the mass of loosely packed polyunsaturated plasma membrane components. CC
GO:0045127 N-acetylglucosamine kinase activity Catalysis of the reaction: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. MF
GO:0045124 regulation of bone resorption Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). BP
GO:0045125 bioactive lipid receptor activity NA MF
GO:0018908 organosulfide cycle NA BP
GO:0018909 dodecyl sulfate metabolic process The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants. BP
GO:0018906 methyl tert-butyl ether metabolic process The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent. BP
GO:0018907 dimethyl sulfoxide metabolic process The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing. BP
GO:0018904 organic ether metabolic process The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. BP
GO:0018905 dimethyl ether metabolic process The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications. BP
GO:0018902 1,3-dichloro-2-propanol metabolic process The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers. BP
GO:0018903 1,3-dichloropropene metabolic process The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes. BP
GO:0018900 dichloromethane metabolic process The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover. BP
GO:0018901 2,4-dichlorophenoxyacetic acid metabolic process The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds. BP
GO:0008378 galactosyltransferase activity Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. MF
GO:0008379 thioredoxin peroxidase activity Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O. MF
GO:0008374 O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. MF
GO:0008375 acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to an oligosaccharide. MF
GO:0008376 acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. MF
GO:0008377 light-induced release of internally sequestered calcium ion The process by which the detection of light triggers the release of internally sequestered calcium ions. BP
GO:0008373 sialyltransferase activity Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. MF
GO:0043586 tongue development The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. BP
GO:0016538 cyclin-dependent protein kinase regulator activity Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. MF
GO:0043584 nose development The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). BP
GO:0043585 nose morphogenesis The process by which the anatomical structures of the nose are generated and organized. Morphogenesis pertains to the creation of form. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). BP
GO:0016531 copper chaperone activity Assists in the delivery of copper ions to target proteins or compartments. MF
GO:0040039 inductive cell migration Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans. BP
GO:0040038 polar body extrusion after meiotic divisions The cell cycle process whereby two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes. BP
GO:0016530 metallochaperone activity Assists in the delivery of metal ions to target proteins or compartments. MF
GO:0040033 negative regulation of mRNA translation, snRNA-mediated Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein. BP
GO:0040032 post-embryonic body morphogenesis The process by which the anatomical structures of the post-embryonic soma are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0040031 snRNA modification The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA. BP
GO:0040030 regulation of protein activity, epigenetic Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. BP
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. BP
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. BP
GO:0040035 hermaphrodite genitalia development The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures. BP
GO:0040034 regulation of development, heterochronic Controlling the timing and/or rate of a developmental event. BP
GO:0046560 scytalidopepsin B activity Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin. MF
GO:0016534 cyclin-dependent protein kinase 5 activator activity NA MF
GO:0043588 skin development The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. BP
GO:0016536 cyclin-dependent protein kinase 5 activator regulator activity Modulation of the activity of cyclin-dependent protein kinase 5 activator. MF
GO:0045177 apical part of cell The apical region of a cell. CC
GO:0045176 apical protein localization The processes by which a protein is transported to, or maintained in, apical regions of the cell. BP
GO:0031796 type 1 metabotropic GABA receptor binding Interacting selectively with a type 1 metabotropic GABA receptor. MF
GO:0031797 type 2 metabotropic GABA receptor binding Interacting selectively with a type 2 metabotropic GABA receptor. MF
GO:0005900 oncostatin-M receptor complex A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta. CC
GO:0005901 caveola A small pit, depression, or invagination, such as any of the minute pits or incuppings of the cell membrane formed during pinocytosis, that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Such caveolae may be pinched off to form free vesicles within the cytoplasm. CC
GO:0005902 microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. CC
GO:0005903 brush border Dense covering of microvilli on the apical surface of epithelial cells in the intestine and kidney; the microvilli aid absorption by increasing the surface area of the cell. CC
GO:0005904 plasma membrane lipid bilayer The phospholipid membrane surrounding a cell that separates the cell from its external environment, excluding intergral and associated proteins. CC
GO:0005905 coated pit An invagination of the cell membrane of many eukaryotic cells, concerned in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane. During endocytosis it is converted into a coated vesicle. The coat is of clathrin. CC
GO:0042369 vitamin D catabolic process The chemical reactions and pathways resulting in the breakdown of vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol. BP
GO:0042368 vitamin D biosynthetic process The chemical reactions and pathways resulting in the formation of vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol. BP
GO:0042361 menaquinone catabolic process The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. BP
GO:0042360 vitamin E metabolic process The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. BP
GO:0042363 fat-soluble vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. BP
GO:0042362 fat-soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. BP
GO:0042365 water-soluble vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water. BP
GO:0042364 water-soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water. BP
GO:0042367 biotin catabolic process The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. BP
GO:0042366 cobalamin catabolic process The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. BP
GO:0003689 DNA clamp loader activity Activity that loads a ring-like DNA polymerase processivity factor, or sliding clamp, on to DNA, coupled to the hydrolysis of ATP. MF
GO:0003688 DNA replication origin binding Interacting selectively with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. MF
GO:0003681 bent DNA binding Interacting selectively with DNA in a bent conformation. MF
GO:0003680 AT DNA binding Interacting selectively with oligo(A) and oligo(T) tracts of DNA (AT DNA). MF
GO:0003682 chromatin binding Interacting selectively with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. MF
GO:0003684 damaged DNA binding Interacting selectively with damaged DNA. MF
GO:0000341 RNA trimethylguanosine cap binding Interacting selectively with the trimethylguanosine (m(3)(2,2,7)-GTP) moiety located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans. MF
GO:0000340 RNA 7-methylguanosine cap binding Interacting selectively with the 7-methylguanosine moiety added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. MF
GO:0000343 plastid-encoded plastid RNA polymerase complex A The plastid-encoded plastid RNA polymerase A (PEP-A) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex. CC
GO:0000342 RNA cap 4 binding Interacting selectively with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa. MF
GO:0000345 cytosolic DNA-directed RNA polymerase (sensu Bacteria) The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0000344 plastid-encoded plastid RNA polymerase complex B The plastid-encoded plastid RNA polymerase B (PEP-B) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation. CC
GO:0000347 THO complex The THO complex is an oligomeric complex, primarily located in the nucleus, that is involved in transcription elongation by RNA polymerase II and is crucial for transcription of certain coding regions. The complex, though not each of the individual subunits, is found in a range of eukaryotic organisms, from S. cerevisiae to metazoans. CC
GO:0000346 transcription export complex The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. CC
GO:0000349 generation of catalytic spliceosome for first transesterification step Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. BP
GO:0000348 nuclear mRNA branch site recognition Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome. BP
GO:0048666 neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0048667 neuron morphogenesis during differentiation The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. BP
GO:0048664 neuron fate determination The process whereby a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0005275 amine transporter activity Enables the directed movement of amines, including polyamines, into, out of, within or between cells. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. MF
GO:0048662 negative regulation of smooth muscle cell proliferation Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. BP
GO:0048663 neuron fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron. BP
GO:0048660 regulation of smooth muscle cell proliferation Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. BP
GO:0048661 positive regulation of smooth muscle cell proliferation Any process that activates or increases the rate or extent of smooth muscle cell proliferation. BP
GO:0048668 collateral sprouting The process by which outgrowths develop from the shafts of existing axons. BP
GO:0005279 amino acid-polyamine transporter activity NA MF
GO:0007528 neuromuscular junction development The process whose specific outcome is the progression of the neuromuscular junction over time, from its formation to the mature structure. BP
GO:0007529 establishment of synaptic specificity at neuromuscular junction The biological process by which a synapse between a motor neuron and a muscle is initially formed. BP
GO:0007520 myoblast fusion The fusion of myoblasts to form myotubes. BP
GO:0007521 muscle cell fate determination Process by which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0007522 visceral muscle development The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure. BP
GO:0007523 larval visceral muscle development The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure. BP
GO:0007524 adult visceral muscle development The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure. BP
GO:0007525 somatic muscle development The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. BP
GO:0007526 larval somatic muscle development The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure. BP
GO:0007527 adult somatic muscle development The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure. BP
GO:0001599 endothelin-A receptor activity A G-protein coupled receptor that preferentially binds endothelin 1. MF
GO:0001598 chemokine receptor-like receptor activity NA MF
GO:0001596 angiotensin type I receptor activity NA MF
GO:0001595 angiotensin receptor activity Combining with angiotensin to initiate a change in cell activity. MF
GO:0001594 trace-amine receptor activity NA MF
GO:0001593 dopamine D4 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors. MF
GO:0001592 dopamine D3 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors. MF
GO:0001591 dopamine D2 receptor-like receptor activity A G-protein coupled receptor that binds the neurotransmitter dopamine and inhibits adenylate cyclase via coupling to Gi/Go. MF
GO:0001590 dopamine D1 receptor activity A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors. MF
GO:0007545 processes downstream of sex determination signal NA BP
GO:0016779 nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant. MF
GO:0016778 diphosphotransferase activity Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). MF
GO:0016773 phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). MF
GO:0016772 transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). MF
GO:0016770 oximinotransaminase activity Catalysis of the reversible transfer of an oxime group to an acceptor. MF
GO:0016777 phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers NA MF
GO:0016776 phosphotransferase activity, phosphate group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). MF
GO:0016775 phosphotransferase activity, nitrogenous group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). MF
GO:0016774 phosphotransferase activity, carboxyl group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). MF
GO:0019718 rough microsome Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside. CC
GO:0019719 smooth microsome Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes. CC
GO:0019710 peptidyl-asparagine methylation The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine. BP
GO:0019711 peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid. BP
GO:0019712 peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid The methyl esterification of peptidyl-glutamic acid. BP
GO:0019713 peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine The coupled methyl esterification and deamidation of peptidyl-glutamine. BP
GO:0019714 peptidyl-glutamine esterification NA BP
GO:0019715 peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid The posttranslational hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). BP
GO:0019716 N-terminal peptidyl-alanine mono-methylation The mono-methylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine. BP
GO:0019717 synaptosome Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma. CC
GO:0031037 myosin II filament disassembly The disassembly of a bipolar filament composed of myosin II molecules. BP
GO:0031036 myosin II filament assembly The formation of a bipolar filament composed of myosin II molecules. BP
GO:0031035 myosin filament disassembly The disassembly of a filament composed of myosin molecules. BP
GO:0031034 myosin filament assembly The aggregation and bonding together of a filament composed of myosin molecules. BP
GO:0031033 myosin filament assembly or disassembly The formation or disassembly of a filament composed of myosin molecules. BP
GO:0031032 actomyosin structure organization and biogenesis The assembly and arrangement of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments. BP
GO:0031031 positive regulation of septation initiation signaling Any process that activates or increases the frequency, rate or extent of septation initiation signaling. BP
GO:0031030 negative regulation of septation initiation signaling Any process that stops, prevents or reduces the frequency, rate or extent of septation initiation signaling. BP
GO:0031039 macronucleus A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell. CC
GO:0031038 myosin II filament assembly or disassembly The formation or disassembly of a bipolar filament composed of myosin II molecules. BP
GO:0015952 purine deoxyribonucleotide interconversion NA BP
GO:0015953 pyrimidine nucleotide interconversion NA BP
GO:0015950 purine nucleotide interconversion NA BP
GO:0015951 purine ribonucleotide interconversion NA BP
GO:0015956 bis(5'-nucleosidyl) oligophosphate metabolic process The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. BP
GO:0015957 bis(5'-nucleosidyl) oligophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. BP
GO:0015954 pyrimidine ribonucleotide interconversion NA BP
GO:0015955 pyrimidine deoxyribonucleotide interconversion NA BP
GO:0015958 bis(5'-nucleosidyl) oligophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules. BP
GO:0015959 diadenosine polyphosphate metabolic process The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. BP
GO:0009229 thiamin diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. BP
GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. BP
GO:0009225 nucleotide-sugar metabolic process The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. BP
GO:0009224 CMP biosynthetic process The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate. BP
GO:0009227 nucleotide-sugar catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. BP
GO:0009226 nucleotide-sugar biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. BP
GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009220 pyrimidine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009223 pyrimidine deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0009222 pyrimidine ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0032214 negative regulation of telomere maintenance via semi-conservative replication Any process that stops, prevents or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA. BP
GO:0009597 detection of virus The series of events in which a stimulus from a virus is received and converted into a molecular signal. BP
GO:0009595 detection of biotic stimulus The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. BP
GO:0009594 detection of nutrient The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal. BP
GO:0009593 detection of chemical stimulus The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. BP
GO:0009590 detection of gravity The series of events in which a gravitational stimulus is received by a cell and converted into a molecular signal. BP
GO:0032212 positive regulation of telomere maintenance via telomerase Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. BP
GO:0007477 notum development The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure. BP
GO:0032211 negative regulation of telomere maintenance via telomerase Any process that stops, prevents or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. BP
GO:0010186 positive regulation of cellular defense response Any process that activates or increases the frequency, rate or extent of cellular defense response. BP
GO:0015355 monocarboxylate porter activity Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. MF
GO:0010182 sugar mediated signaling The process by which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes. BP
GO:0010183 pollen tube guidance The process by which the growth of pollen tube is directed towards the female gametophyte. BP
GO:0010180 thioglucosidase binding activity Interacting selectively with the enzyme thioglucosidase. MF
GO:0015353 multidrug endosomal transporter activity NA MF
GO:0008172 S-methyltransferase activity Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. MF
GO:0008173 RNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. MF
GO:0008170 N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. MF
GO:0008171 O-methyltransferase activity Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. MF
GO:0008176 tRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. MF
GO:0008177 succinate dehydrogenase (ubiquinone) activity Catalysis of the reaction: succinate + quinone = fumarate + quinol. MF
GO:0008174 mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. MF
GO:0008175 tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. MF
GO:0008179 adenylate cyclase binding Interacting selectively with the enzyme adenylate cyclase. MF
GO:0010189 vitamin E biosynthetic process The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. BP
GO:0045249 pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Bacteria) A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045248 oxoglutarate dehydrogenase complex (sensu Bacteria) A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045243 isocitrate dehydrogenase complex (NAD+) (sensu Bacteria) Complex that possesses isocitrate dehydrogenase (NAD+) activity. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045242 isocitrate dehydrogenase complex (NAD+) Complex that possesses isocitrate dehydrogenase (NAD+) activity. CC
GO:0045241 alpha-ketoglutarate dehydrogenase complex (sensu Bacteria) Complex that possesses alpha-ketoglutarate dehydrogenase activity. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045240 alpha-ketoglutarate dehydrogenase complex Complex that possesses alpha-ketoglutarate dehydrogenase activity. CC
GO:0045247 electron transfer flavoprotein complex (sensu Bacteria) A protein complex containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045246 tricarboxylic acid cycle enzyme complex (sensu Bacteria) Any of the heteromeric enzymes that act in the TCA cycle, as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045244 succinate-CoA ligase complex (GDP-forming) A heterodimeric enzyme complex, usually composed of an alpha and beta chain and found in eukaryotes. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP. CC
GO:0032717 negative regulation of interleukin-8 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. BP
GO:0032716 negative regulation of interleukin-7 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production. BP
GO:0032715 negative regulation of interleukin-6 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. BP
GO:0032714 negative regulation of interleukin-5 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production. BP
GO:0032713 negative regulation of interleukin-4 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production. BP
GO:0032712 negative regulation of interleukin-3 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production. BP
GO:0032711 negative regulation of interleukin-27 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production. BP
GO:0032710 negative regulation of interleukin-26 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production. BP
GO:0032719 negative regulation of TRAIL production Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production. BP
GO:0032718 negative regulation of interleukin-9 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production. BP
GO:0015163 hexuronide transporter activity Enables the directed movement of hexuronide into, out of, within or between cells. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate. MF
GO:0015162 teichoic acid transporter activity Enables the directed movement of teichoic acid into, out of, within or between cells. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. MF
GO:0015161 capsular-polysaccharide transporter activity Enables the directed movement of capsular-polysaccharides into, out of, within or between cells. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. MF
GO:0015160 beta-glucan transporter activity Enables the directed movement of beta-glucans into, out of, within or between cells. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. MF
GO:0015167 arabitol transporter activity Enables the directed movement of arabitol into, out of, within or between cells. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. MF
GO:0015166 polyol transporter activity Enables the directed movement of polyols, polyhydric alcohols, into, out of, within or between cells. MF
GO:0015165 pyrimidine nucleotide sugar transporter activity Enables the directed movement of pyrimidine nucleotide-sugars into, out of, within or between cells. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. MF
GO:0015164 glucuronoside transporter activity Enables the directed movement of glucuronosides into, out of, within or between cells. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. MF
GO:0015169 glycerol-3-phosphate transporter activity Enables the directed movement of glycerol-3-phosphate into, out of, within or between cells. Glycerol-3-phosphate is a phosphoric monoester of glycerol. MF
GO:0015168 glycerol transporter activity Enables the directed movement of glycerol into, out of, within or between cells. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. MF
GO:0047087 protopine 6-monooxygenase activity Catalysis of the reaction: O2 + NADPH + protopine = H2O + NADP+ + 6-hydroxyprotopine. MF
GO:0047086 ketosteroid monooxygenase activity Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. MF
GO:0047085 hydroxyphenylacetonitrile 2-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + 4-hydroxyphenylacetonitrile = H2O + NADP+ + 4-hydroxymandelonitrile. MF
GO:0047084 methyltetrahydroprotoberberine 14-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine. MF
GO:0047083 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate. MF
GO:0047082 3,9-dihydroxypterocarpan 6a-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + (6aR,11aR)-3,9-dihydroxypterocarpan = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol. MF
GO:0047081 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity Catalysis of the reaction: O2 + NAD(P)H + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NAD(P)+ + 2-(acetamidomethylene)succinate. MF
GO:0047080 pyrimidine-deoxynucleoside 2'-dioxygenase activity Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + uridine. MF
GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. BP
GO:0047089 dihydrochelirubine 12-monooxygenase activity Catalysis of the reaction: O2 + NADPH + dihydrochelirubine = H2O + NADP+ + 10-hydroxydihydrochelirubine. MF
GO:0047088 dihydrosanguinarine 10-monooxygenase activity Catalysis of the reaction: O2 + NADPH + dihydrosanguinarine = H2O + NADP+ + 10-hydroxydihydrosanguinarine. MF
GO:0009069 serine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. BP
GO:0009068 aspartate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. BP
GO:0035059 RCAF complex A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4. CC
GO:0035058 sensory cilium biogenesis The assembly of a sensory cilium, a primary cilium found on sensory neurons that contains an a 9+0 axonemal arrangement of microtubules. BP
GO:0030029 actin filament-based process Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. BP
GO:0030027 lamellipodium A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. CC
GO:0030026 manganese ion homeostasis The regulation of the levels, transport, and metabolism of manganese ions within a cell or between a cell and its external environment. BP
GO:0035057 positive regulation of nuclear mRNA splicing via U2-type spliceosome Any process that activates or increases the rate or extent of mRNA splicing via a U2-type spliceosome. BP
GO:0035056 negative regulation of nuclear mRNA splicing via U2-type spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a U2-type spliceosome. BP
GO:0035051 cardiac cell differentiation The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. BP
GO:0035050 embryonic heart tube development The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. BP
GO:0030021 extracellular matrix structural constituent conferring compression resistance A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. MF
GO:0030020 extracellular matrix structural constituent conferring tensile strength A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress. MF
GO:0031990 mRNA export from nucleus during heat stress The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export. BP
GO:0031991 regulation of contractile ring contraction during cytokinesis Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring during cytokinesis. BP
GO:0031992 energy transducer activity Absorbing energy and converting it to another form, often by transfer to another molecule within the cell. MF
GO:0031993 light transducer activity Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell. MF
GO:0031994 insulin-like growth factor I binding Interacting selectively with insulin-like growth factor I. MF
GO:0031995 insulin-like growth factor II binding Interacting selectively with insulin-like growth factor II. MF
GO:0031996 thioesterase binding Interacting selectively with any thioesterase enzyme. MF
GO:0031997 N-terminal myristoylation domain binding Interacting selectively with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin. MF
GO:0031998 regulation of fatty acid beta-oxidation Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. BP
GO:0031999 negative regulation of fatty acid beta-oxidation Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation. BP
GO:0043353 enucleate erythrocyte differentiation The process by which a myeloid precursor cell acquires specializes features of an erythrocyte without a nucleus, as found in mammals. BP
GO:0043352 neuroblast activation (sensu Vertebrata) A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043351 neuroblast activation (sensu Nematoda and Protostomia) A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043350 neuroblast proliferation (sensu Vertebrata) The rapid expansion of a neuroblast population by cell division. Neuroblasts are embryonic cells which develop into nerve cells or neurons. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0043357 pigment cell differentiation (sensu Nematoda and Protostomia) The process whereby a relatively unspecialized cell acquires the specialized features of a pigmented cell. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043356 epidermal cell fate specification (sensu Insecta) Process by which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0043355 epidermal cell differentiation (sensu Insecta) The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0043354 enucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. BP
GO:0043359 glial cell migration (sensu Nematoda and Protostomia) The orderly movement of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043358 pigment cell differentiation (sensu Vertebrata) The process whereby a relatively unspecialized cell acquires the specialized features of a pigmented cell. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742). BP
GO:0048464 calyx development The process whose specific outcome is the progression of the calyx over time, from its formation to the mature structure. BP
GO:0048465 corolla development The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure. BP
GO:0048466 androecium development The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure. BP
GO:0048467 gynoecium development The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower. BP
GO:0048460 flower formation The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0048461 flower structural organization The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048462 carpel formation The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts. BP
GO:0048463 carpel structural organization The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure. BP
GO:0048468 cell development The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. BP
GO:0048469 cell maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. BP
GO:0009968 negative regulation of signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction. BP
GO:0009969 xyloglucan biosynthetic process The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of 1->4-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-1->6 residues, which is present in the primary cell wall of most higher plants. BP
GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. BP
GO:0009967 positive regulation of signal transduction Any process that activates or increases the frequency, rate or extent of signal transduction. BP
GO:0009964 negative regulation of flavonoid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. BP
GO:0009965 leaf morphogenesis The process by which the anatomical structures of the leaf are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0009962 regulation of flavonoid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. BP
GO:0009963 positive regulation of flavonoid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. BP
GO:0009960 endosperm development The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo. BP
GO:0009961 response to 1-aminocyclopropane-1-carboxylic acid A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus. BP
GO:0042750 hibernation The processes by which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs. BP
GO:0042751 estivation The processes by which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season. BP
GO:0042752 regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm behavior. BP
GO:0042753 positive regulation of circadian rhythm Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. BP
GO:0042754 negative regulation of circadian rhythm Any process that stops, prevents or reduces the frequency, rate or extent of a circadian rhythm behavior. BP
GO:0042755 eating behavior The specific actions or reactions of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. BP
GO:0042756 drinking behavior The specific actions or reactions of an organism relating to the intake of liquids, especially water. BP
GO:0042757 giant axon Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses. CC
GO:0042758 long-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18. BP
GO:0042759 long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18. BP
GO:0031376 cytosolic type II fatty acid synthase complex A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol. CC
GO:0031377 mitochondrial type II fatty acid synthase complex A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion. CC
GO:0031370 eukaryotic initiation factor 4G binding Interacting selectively with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. MF
GO:0031371 ubiquitin conjugating enzyme complex Any complex that possesses ubiquitin conjugating enzyme activity. CC
GO:0031372 UBC13-MMS2 complex A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p. CC
GO:0031373 cytosolic fatty acid synthase complex A fatty acid synthase complex located in the cytosol. CC
GO:0050454 coenzyme F420 hydrogenase activity Catalysis of the reaction: H2 + coenzyme F420 = reduced coenzyme F420. MF
GO:0050455 columbamine oxidase activity Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O. MF
GO:0050456 cystine reductase activity Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + NADH + H+. MF
GO:0050457 decylcitrate synthase activity Catalysis of the reaction: lauroyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA . MF
GO:0050450 citrate (Re)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA . MF
GO:0050451 CoA-disulfide reductase activity Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+. MF
GO:0050452 CoA-glutathione reductase activity Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+. MF
GO:0050453 cob(II)alamin reductase activity Catalysis of the reaction: 2 cob(I)alamin + NAD+ = 2 cob(II)alamin + NADH + H+. MF
GO:0050458 decylhomocitrate synthase activity Catalysis of the reaction: dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA . MF
GO:0050459 ethanolamine-phosphate phospho-lyase activity Catalysis of the reaction: ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate. MF
GO:0032058 positive regulation of translation initiation in response to stress Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. BP
GO:0032059 bleb A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions. CC
GO:0032054 basal body duplication Construction of a new basal body. BP
GO:0032055 negative regulation of translation in response to stress Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress. BP
GO:0032056 positive regulation of translation in response to stress Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. BP
GO:0032057 negative regulation of translation initiation in response to stress Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. BP
GO:0032050 clathrin heavy chain binding Interacting selectively with a clathrin heavy chain. MF
GO:0032051 clathrin light chain binding Interacting selectively with a clathrin light chain. MF
GO:0032052 bile acid binding Interacting selectively with bile acids, any of a group of steroid carboxylic acids occurring in bile. MF
GO:0032053 basal body organization and biogenesis The assembly and arrangement of a basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum. BP
GO:0048937 lateral line nerve glial cell development The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. BP
GO:0019260 1,2-dichloroethane catabolic process The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride. BP
GO:0019261 1,4-dichlorobenzene catabolic process The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. BP
GO:0019262 N-acetylneuraminate catabolic process The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid. BP
GO:0019263 adamantanone catabolic process The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. BP
GO:0019264 glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine. BP
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate. BP
GO:0019266 asparagine biosynthetic process from oxaloacetate The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate. BP
GO:0019267 asparagine biosynthetic process from cysteine The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine. BP
GO:0019840 isoprenoid binding Interacting selectively with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. MF
GO:0019841 retinol binding Interacting selectively with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. MF
GO:0019842 vitamin binding Interacting selectively with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. MF
GO:0019843 rRNA binding Interacting selectively with ribosomal RNA. MF
GO:0060001 minus-end directed actin-filament motor activity Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers. MF
GO:0060002 plus-end directed actin-filament motor activity Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers. MF
GO:0060003 copper ion export The directed movement of copper ions out of a cell or organelle. BP
GO:0060004 reflex process An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of conciousness. BP
GO:0060005 vestibular reflex A reflex process by which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of conciousness. BP
GO:0060006 angular vestibuloocular reflex A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of conciousness. BP
GO:0060007 linear vestibuloocular reflex A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of conciousness. BP
GO:0060008 Sertoli cell differentiation The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. BP
GO:0060009 Sertoli cell development The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. BP
GO:0006448 regulation of translational elongation Any process that modulates the frequency, rate or extent of translational elongation. BP
GO:0006449 regulation of translational termination Any process that modulates the frequency, rate or extent of translational termination. BP
GO:0006446 regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. BP
GO:0006447 regulation of translational initiation by iron Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron. BP
GO:0035318 wing hair outgrowth Extrusion of a cellular projection from the apical membrane of a wing epithelial cell. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair. BP
GO:0035319 wing hair elongation Growth of a prehair in the approximately 10 hour period following its emergence from a wing epidermal cell. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles. BP
GO:0035312 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. MF
GO:0035313 wound healing, spreading of epidermal cells The migration of epithelial cells along or through a wound gap to reestablish a continuous epithelium. BP
GO:0035310 notum cell fate specification Process by which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment. BP
GO:0035311 wing cell fate specification Process by which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment. BP
GO:0035316 trichome organization and biogenesis (sensu Insecta) Formation and arrangement of hairs (trichomes), polarized cellular extensions that cover much of the insect epidermis. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0035317 wing hair organization and biogenesis Formation and arrangement of a wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. BP
GO:0035314 scab formation Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection. BP
GO:0035315 hair cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a hair cell. BP
GO:0000136 alpha-1,6-mannosyltransferase complex A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins. CC
GO:0000137 Golgi cis cisterna The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. CC
GO:0000135 septin checkpoint A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed. BP
GO:0000132 establishment of mitotic spindle orientation The processes that set the alignment of mitotic spindle relative to other cellular structures. BP
GO:0000133 polarisome Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p. CC
GO:0000131 incipient bud site The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence. CC
GO:0000138 Golgi trans cisterna The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. CC
GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. CC
GO:0045059 positive thymic T cell selection The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. BP
GO:0051093 negative regulation of developmental process Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). BP
GO:0051092 activation of NF-kappaB transcription factor Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. BP
GO:0051091 positive regulation of transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. BP
GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. BP
GO:0051097 negative regulation of helicase activity Any process that stops or reduces the activity of a helicase. BP
GO:0051096 positive regulation of helicase activity Any process that activates or increases the activity of a helicase. BP
GO:0051095 regulation of helicase activity Any process that modulates the frequency, rate or extent of helicase activity. BP
GO:0051094 positive regulation of developmental process Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). BP
GO:0051099 positive regulation of binding Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. BP
GO:0051098 regulation of binding Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. BP
GO:0015361 low affinity sodium:dicarboxylate symporter activity Catalysis of the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). MF
GO:0015360 acetate:hydrogen symporter activity Catalysis of the reaction: acetate(out) = acetate(in). MF
GO:0015362 high affinity sodium:dicarboxylate symporter activity Catalysis of the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). MF
GO:0015365 dicarboxylic acid permease activity NA MF
GO:0015364 dicarboxylate:inorganic phosphate antiporter activity Catalysis of the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out). MF
GO:0015367 oxoglutarate:malate antiporter activity Catalysis of the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out). MF
GO:0015366 malate:hydrogen symporter activity Catalysis of the reaction: malate(out) + H+(out) = malate(in) + H+(in). MF
GO:0015369 calcium:hydrogen antiporter activity Catalysis of the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). MF
GO:0015368 calcium:cation antiporter activity Catalysis of the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). MF
GO:0021902 commitment of a neuronal cell to a specific type of neuron in the forebrain The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain. BP
GO:0021903 rostrocaudal neural tube patterning The process by which the neural tube is divided into specific regions along the rostrocaudal axis. BP
GO:0021900 ventricular zone cell fate commitment The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons. BP
GO:0021901 early neuron fate commitment in the forebrain The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain. BP
GO:0021906 hindbrain-spinal cord boundary formation The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. BP
GO:0021907 fibroblast growth factor receptor signaling pathway in spinal cord anterior-posterior patterning The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. BP
GO:0021904 dorsoventral neural tube patterning The process by which the neural tube is regionalized in the dorsoventral axis. BP
GO:0021905 forebrain-midbrain boundary formation The process whose specific outcome is the creation of the forebrain-midbrain boundary. BP
GO:0021908 retinoic acid receptor signaling pathway in spinal cord anterior-posterior patterning The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. BP
GO:0021909 regulation of transcription from RNA polymerase II promoter in spinal cord anterior-posterior patterning Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. BP
GO:0042310 vasoconstriction A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure. BP
GO:0042311 vasodilation An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. BP
GO:0042312 regulation of vasodilation Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels. BP
GO:0051545 negative regulation of elastin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. BP
GO:0051544 positive regulation of elastin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. BP
GO:0051547 regulation of keratinocyte migration Any process that modulates the frequency, rate or extent of keratinocyte migration. BP
GO:0051546 keratinocyte migration The directed movement of keratinocytes, epidermal cells which synthesize keratin, from one site to another. BP
GO:0051541 elastin metabolic process The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and cross linked to form elastic fibres that are found in connective tissue. BP
GO:0051540 metal cluster binding Interacting selectively with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. MF
GO:0051543 regulation of elastin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin. BP
GO:0051542 elastin biosynthetic process The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries. BP
GO:0042314 bacteriochlorophyll binding Interacting selectively with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants. MF
GO:0051549 positive regulation of keratinocyte migration Any process that activates or increases the frequency, rate or extent of keratinocyte migration. BP
GO:0051548 negative regulation of keratinocyte migration Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte migration. BP
GO:0042315 cytosol nonspecific dipeptidase activity Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. MF
GO:0018678 4-hydroxybenzoate 1-hydroxylase activity Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2. MF
GO:0018679 dibenzothiophene-5,5-dioxide monooxygenase activity Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate. MF
GO:0042316 penicillin metabolic process The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus. BP
GO:0018670 4-aminobenzoate 1-monooxygenase activity Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2. MF
GO:0018671 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O. MF
GO:0018672 anthranilate 3-monooxygenase (deaminating) activity Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3. MF
GO:0018673 anthraniloyl-CoA monooxygenase activity Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+. MF
GO:0018674 (S)-limonene 3-monooxygenase activity Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-isopiperitenol + NADP+ + H2O. MF
GO:0018675 (S)-limonene 6-monooxygenase activity Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O. MF
GO:0018676 (S)-limonene 7-monooxygenase activity Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-perillyl alcohol + NADP+ + H2O. MF
GO:0018677 pentachlorophenol monooxygenase activity Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride. MF
GO:0019109 acyl-CoA reductase activity NA MF
GO:0019108 aryl-aldehyde dehydrogenase activity Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+. MF
GO:0019101 female somatic sex determination The determination of sex and sexual phenotypes in a female organism's soma. BP
GO:0019100 male germ-line sex determination The determination of sex and sexual phenotype in a male organism's germ line. BP
GO:0019103 pyrimidine nucleotide binding Interacting selectively with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate. MF
GO:0019102 male somatic sex determination The determination of sex and sexual phenotypes in a male organism's soma. BP
GO:0019105 N-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule. MF
GO:0019104 DNA N-glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. MF
GO:0019107 myristoyltransferase activity Catalysis of the transfer of an myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. MF
GO:0008969 phosphohistidine phosphatase activity Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate. MF
GO:0030229 very-low-density lipoprotein receptor activity Combining with a very-low-density lipoprotein to initiate a change in cell activity. MF
GO:0030228 lipoprotein receptor activity Combining with a lipoprotein to initiate a change in cell activity. A lipoprotein is any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids; the lipid may be triacylglycerol, cholesterol, or phospholipid, or a combination of these. MF
GO:0008968 phosphoheptose isomerase activity Catalysis of the conversion of sedoheptulose 7-phosphate to D-glycero-D-mannoheptose 7-phosphate. MF
GO:0030225 macrophage differentiation The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. BP
GO:0030224 monocyte differentiation The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. BP
GO:0030227 apolipoprotein E receptor activity Combining with apolipoprotein E to initiate a change in cell activity. MF
GO:0030226 apolipoprotein receptor activity Combining with an apolipoprotein, the protein component of a lipoprotein, to initiate a change in cell activity. MF
GO:0030221 basophil differentiation The process whereby a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell. BP
GO:0030220 platelet formation The process by which platelets bud from long processes extended by megakaryocytes. BP
GO:0030223 neutrophil differentiation The process by which a myeloid precursor cell acquires the specialized features of a neutrophil. BP
GO:0030222 eosinophil differentiation The process whereby a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil. BP
GO:0052018 modulation by symbiont of host RNA levels The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052019 modulation by symbiont of host hormone or growth regulator levels The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052012 catabolism by symbiont of host cell wall chitin The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052013 catabolism by symbiont of host macromolecule The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052010 catabolism by symbiont of host cell wall cellulose The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052011 catabolism by symbiont of host cell wall pectin The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052016 catabolism by symbiont of host glucan The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052017 catabolism by symbiont of host xylan The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052014 catabolism by symbiont of host protein The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052015 catabolism by symbiont of host carbohydrate The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0016108 tetraterpenoid metabolic process The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units. BP
GO:0016109 tetraterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units. BP
GO:0008960 phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose. MF
GO:0016100 monoterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids with two isoprene units. BP
GO:0016101 diterpenoid metabolic process The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units. BP
GO:0016102 diterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units. BP
GO:0016103 diterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units. BP
GO:0016104 triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units. BP
GO:0016105 triterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units. BP
GO:0016106 sesquiterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units. BP
GO:0016107 sesquiterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units. BP
GO:0030597 RNA glycosylase activity Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule. MF
GO:0030596 alpha-L-rhamnosidase activity Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. MF
GO:0030595 leukocyte chemotaxis The movement of a leukocyte in response to an external stimulus. BP
GO:0030594 neurotransmitter receptor activity Combining with a neurotransmitter to initiate a change in cell activity. MF
GO:0030593 neutrophil chemotaxis The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. BP
GO:0030592 DNA ADP-ribosylation The covalent attachment of an ADP-ribosyl moiety to the amino group at N2 of a 2'-deoxyguanosine residue in double-stranded DNA. BP
GO:0030591 NAD DNA ADP-ribosyltransferase activity Catalysis of the transfer of the ADP-ribose moiety of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form. MF
GO:0030590 pseudocleavage (sensu Nematoda) A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0006901 vesicle coating A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. BP
GO:0030599 pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate. MF
GO:0030598 rRNA N-glycosylase activity Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species. MF
GO:0048066 pigmentation during development The deposition of coloring matter in an organism, tissue or cell, occurring during development. BP
GO:0048067 cuticle pigmentation Establishment of a pattern of pigment in the cuticle of an organism. BP
GO:0031172 ornithine N5-monooxygenase activity Catalysis of the reaction: L-ornithine + O2 + donor-H2 = N5-hydroxy-L-ornithine + acceptor + H2O. MF
GO:0031173 otolith mineralization (sensu Tetrapoda) The formation of otoconia by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear. As in, but not restricted to, the tetrapods (Tetrapoda, ncbi_taxonomy_id:32523). BP
GO:0031170 ferricrocin metabolic process The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3. BP
GO:0031171 ferricrocin biosynthetic process The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3. BP
GO:0031176 endo-1,4-beta-xylanase activity Catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans. MF
GO:0031177 phosphopantetheine binding Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). MF
GO:0031174 otolith mineralization (sensu Actinopterygii) The formation and growth of otoliths, the large extracellular ear-stones of the fish inner ear, by precipitation of specific crystal forms of calcium carbonate on organic matrices. As in, but not restricted to, the ray-finned fishes (Actinopterygii, ncbi_taxonomy_id:7898). BP
GO:0031175 neurite development The process whose specific outcome is the progression of the neurite over time, from its formation to the mature structure. The neurite is any process extending from a neural cell, such as axons or dendrites. BP
GO:0031178 siderophore biosynthetic process, peptide formation The chemical reactions and pathways resulting in the formation of the peptide backbone of a siderophore; occurs by non-ribosomal peptide synthesis. BP
GO:0031179 peptide modification The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide. BP
GO:0009413 response to flooding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water. BP
GO:0009410 response to xenobiotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. BP
GO:0009411 response to UV A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. BP
GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. BP
GO:0009414 response to water deprivation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. BP
GO:0009415 response to water A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. BP
GO:0009418 fimbrial shaft The long, slender, mid section of a fimbrium. CC
GO:0009419 fimbrial tip The pointed extremity furthest from the cell of a fimbrium. CC
GO:0046929 negative regulation of neurotransmitter secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. BP
GO:0046928 regulation of neurotransmitter secretion Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells. BP
GO:0046923 ER retention sequence binding Interacting selectively with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. MF
GO:0046922 peptide-O-fucosyltransferase activity Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. MF
GO:0046921 alpha(1,6)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,6)-linkage. MF
GO:0046920 alpha(1,3)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,3)-linkage. MF
GO:0046927 peptidyl-threonine racemization The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine. BP
GO:0046926 peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine. BP
GO:0046925 peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine The posttranslational cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine. BP
GO:0046924 peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine The posttranslational cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine. BP
GO:0043265 ectoplasm Granule free cytoplasm, lying immediately below the plasma membrane. CC
GO:0021989 olfactory cortex development The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors. BP
GO:0043269 regulation of ion transport Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells. BP
GO:0043268 positive regulation of potassium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells. BP
GO:0042691 positive regulation of crystal cell differentiation Any process that activates or increases the frequency, rate or extent of crystal cell differentiation. BP
GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. MF
GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. MF
GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. MF
GO:0008456 alpha-N-acetylgalactosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. MF
GO:0008451 X-Pro aminopeptidase activity Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide. MF
GO:0008450 O-sialoglycoprotein endopeptidase activity Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. MF
GO:0008453 alanine-glyoxylate transaminase activity Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. MF
GO:0008452 RNA ligase activity NA MF
GO:0008459 chondroitin 6-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. MF
GO:0008458 carnitine O-octanoyltransferase activity Catalysis of the reaction: octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine. MF
GO:0042690 negative regulation of crystal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of crystal cell differentiation. BP
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP. MF
GO:0042131 thiamin phosphate phosphatase activity Catalysis of the hydrolysis of thiamin phosphate. MF
GO:0047320 D-4-hydroxyphenylglycine transaminase activity Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = L-glutamate + 4-hydroxyphenylglyoxylate. MF
GO:0042133 neurotransmitter metabolic process The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. BP
GO:0047326 inositol tetrakisphosphate 5-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. MF
GO:0042135 neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. BP
GO:0042136 neurotransmitter biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. BP
GO:0042137 sequestering of neurotransmitter The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system. BP
GO:0042138 meiotic DNA double-strand break formation The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. BP
GO:0042139 early meiotic recombination nodule assembly The assembly of small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene. BP
GO:0047328 acyl-phosphate-hexose phosphotransferase activity Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid. MF
GO:0047329 phosphoramidate-hexose phosphotransferase activity Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3. MF
GO:0045782 positive regulation of cell budding Any process that activates or increases the frequency, rate or extent of cell budding. BP
GO:0045780 positive regulation of bone resorption Any process that activates or increases the frequency, rate or extent of bone resorption. BP
GO:0045781 negative regulation of cell budding Any process that stops, prevents or reduces the frequency, rate or extent of cell budding. BP
GO:0045786 negative regulation of progression through cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of progression through the cell cycle. BP
GO:0045787 positive regulation of progression through cell cycle Any process that activates or increases the frequency, rate or extent of progression through the cell cycle. BP
GO:0045785 positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion. BP
GO:0030968 unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. BP
GO:0030969 UFP-specific transcription factor mRNA processing during unfolded protein response The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes. BP
GO:0030966 NADH dehydrogenase complex (quinone) (sensu Bacteria) Complex that possesses NADH dehydrogenase (quinone) activity, as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0030967 ER-nuclear sterol response pathway The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of sterol depletion, and resulting in the activation of transcription by SREBP. BP
GO:0030964 NADH dehydrogenase complex (quinone) Complex that possesses NADH dehydrogenase (quinone) activity. CC
GO:0030965 plasma membrane electron transport, NADH to quinone The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as NADH-quinone oxidoreductase. BP
GO:0030962 peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine. BP
GO:0030963 peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine. BP
GO:0030960 peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine The posttranslation modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link. BP
GO:0030961 peptidyl-arginine hydroxylation The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine. BP
GO:0050948 positive regulation of early stripe melanocyte differentiation Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation. BP
GO:0050949 negative regulation of late stripe melanocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of late stripe melanocyte differentiation. BP
GO:0050946 positive regulation of xanthophore differentiation Any process that activates or increases the frequency, rate or extent of xanthophore differentiation. BP
GO:0050947 negative regulation of early stripe melanocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of early stripe melanocyte differentiation. BP
GO:0050944 negative regulation of xanthophore differentiation Any process that stops, prevents or reduces the frequency, rate or extent of xanthophore differentiation. BP
GO:0050945 positive regulation of iridophore differentiation Any process that activates or increases the frequency, rate or extent of iridophore differentiation. BP
GO:0050942 positive regulation of pigment cell differentiation Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. BP
GO:0050943 negative regulation of iridophore differentiation Any process that stops, prevents or reduces the frequency, rate or extent of iridophore differentiation. BP
GO:0050940 regulation of late stripe melanocyte differentiation Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation. BP
GO:0050941 negative regulation of pigment cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of pigment cell differentiation. BP
GO:0046493 lipid A metabolic process The chemical reactions and pathways involving lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. BP
GO:0046492 heme b metabolic process The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. BP
GO:0046491 L-methylmalonyl-CoA metabolic process The chemical reactions and pathways involving L-methylmalonyl-CoA, the levorotatory isomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals. BP
GO:0046490 isopentenyl diphosphate metabolic process The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. BP
GO:0046497 nicotinate nucleotide metabolic process The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin). BP
GO:0046496 nicotinamide nucleotide metabolic process The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. BP
GO:0046495 nicotinamide riboside metabolic process The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. BP
GO:0046494 rhizobactin 1021 metabolic process The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. BP
GO:0046499 S-adenosylmethioninamine metabolic process The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. BP
GO:0046498 S-adenosylhomocysteine metabolic process The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. BP
GO:0002761 regulation of myeloid leukocyte differentiation Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. BP
GO:0002760 positive regulation of antimicrobial humoral response Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response. BP
GO:0002763 positive regulation of myeloid leukocyte differentiation Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. BP
GO:0002762 negative regulation of myeloid leukocyte differentiation Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. BP
GO:0002765 immune response-inhibiting signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response. BP
GO:0002764 immune response-regulating signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response. BP
GO:0002767 immune response-inhibiting cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response. BP
GO:0002766 innate immune response-inhibiting signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response. BP
GO:0002769 natural killer cell inhibitory signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response. BP
GO:0002768 immune response-regulating cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. BP
GO:0042696 menarche The beginning of the menstrual cycle; the first menstrual cycle in an individual. BP
GO:0050584 linoleate 11-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate. MF
GO:0044433 cytoplasmic vesicle part Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. CC
GO:0044432 endoplasmic reticulum part Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. CC
GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. CC
GO:0044430 cytoskeletal part Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. CC
GO:0044437 vacuolar part Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. CC
GO:0044436 thylakoid part Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms. CC
GO:0044435 plastid part Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. CC
GO:0044434 chloroplast part Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. CC
GO:0044439 peroxisomal part Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). CC
GO:0044438 microbody part Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). CC
GO:0009885 transmembrane histidine kinase cytokinin receptor activity A transmembrane receptor of cytokinins that produces a molecular signal via phosphotransfer at histidine residues. MF
GO:0009884 cytokinin receptor activity Combining with a cytokinin to initiate a change in cell activity. MF
GO:0009887 organ morphogenesis Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. BP
GO:0009886 post-embryonic morphogenesis The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0009881 photoreceptor activity The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. MF
GO:0009880 embryonic pattern specification The process that results in the patterns of cell differentiation that will arise in an embryo. BP
GO:0009883 red or far-red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation. MF
GO:0009882 blue light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. MF
GO:0009889 regulation of biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. BP
GO:0009888 tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. BP
GO:0046145 D-alanine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids. BP
GO:0046144 D-alanine family amino acid metabolic process The chemical reactions and pathways involving D-alanine and related amino acids. BP
GO:0046147 tetrahydrobiopterin catabolic process The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. BP
GO:0046146 tetrahydrobiopterin metabolic process The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. BP
GO:0046141 corrin catabolic process The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. BP
GO:0046140 corrin biosynthetic process The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule. BP
GO:0046149 pigment catabolic process The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. BP
GO:0046148 pigment biosynthetic process The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. BP
GO:0050588 apo-beta-carotenoid-14',13'-dioxygenase activity Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = 14'-apo-beta-carotenal + H2O. MF
GO:0050589 leucocyanidin oxygenase activity Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O. MF
GO:0019088 immortalization of host cell by virus A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase. BP
GO:0021536 diencephalon development The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. BP
GO:0048235 sperm cell differentiation (sensu Magnoliophyta) The process whereby a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0048234 male gamete generation (sensu Magnoliophyta) The generation, maintenance, and proliferation of male gametes, as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0048237 rough endoplasmic reticulum lumen The volume enclosed by the membranes of the rough endoplasmic reticulum. CC
GO:0048236 spore development (sensu Magnoliophyta) The process whose specific outcome is the progression of the spore over time, from its formation to the mature structure. The spore gives rise to gametophytes. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0019086 late viral mRNA transcription The last group of viral genes to be transcribed during the viral life cycle; genes consist mainly of those encoding structural proteins. BP
GO:0048233 female gamete generation (sensu Magnoliophyta) The generation, maintenance, and proliferation of female gametes, as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0048232 male gamete generation Generation of the male gamete; specialised haploid cells produced by meiosis and involved in sexual reproduction. BP
GO:0019087 transformation of host cell by virus Any virus-induced change in the morphological, biochemical, or growth parameters of a cell. BP
GO:0048239 negative regulation of telomeric recombination at telomere Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the telomere. BP
GO:0048238 smooth endoplasmic reticulum lumen The volume enclosed by the membranes of the smooth endoplasmic reticulum. CC
GO:0004358 glutamate N-acetyltransferase activity Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate. MF
GO:0004359 glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. MF
GO:0004356 glutamate-ammonia ligase activity Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. MF
GO:0004357 glutamate-cysteine ligase activity Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. MF
GO:0004354 glutamate dehydrogenase (NADP+) activity Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. MF
GO:0004355 glutamate synthase (NADPH) activity Catalysis of the reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+. MF
GO:0042493 response to drug A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. BP
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. MF
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. MF
GO:0042490 mechanoreceptor differentiation The process whereby a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. BP
GO:0006842 tricarboxylic acid transport The directed movement of tricarboxylic acids into, out of, within or between cells. BP
GO:0006843 mitochondrial citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion. BP
GO:0008868 galactitol-1-phosphate 5-dehydrogenase activity Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+. MF
GO:0008869 galactonate dehydratase activity Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O. MF
GO:0006846 acetate transport The directed movement of acetate into, out of, within or between cells. BP
GO:0006847 plasma membrane acetate transport The directed movement of acetate across a plasma membrane. BP
GO:0006848 pyruvate transport The directed movement of pyruvate into, out of, within or between cells. BP
GO:0006849 plasma membrane pyruvate transport The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane. BP
GO:0008866 fructuronate reductase activity Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+. MF
GO:0008867 galactarate dehydratase activity Catalysis of the reaction: D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O. MF
GO:0008860 ferredoxin-NAD+ reductase activity Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+. MF
GO:0008861 formate C-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate. MF
GO:0008863 formate dehydrogenase activity Catalysis of the reaction: formate + NAD+ = CO2 + NADH + H+. MF
GO:0018478 malonate-semialdehyde dehydrogenase (acetylating) activity Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+. MF
GO:0018479 benzaldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. MF
GO:0018477 benzaldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+. MF
GO:0018474 2-carboxybenzaldehyde dehydrogenase activity Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate. MF
GO:0018475 trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid. MF
GO:0018472 1-hydroxy-2-naphthaldehyde dehydrogenase activity Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate. MF
GO:0018473 cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid. MF
GO:0018470 4-hydroxybutaraldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate. MF
GO:0018471 4-chlorobenzaldehyde oxidase activity Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-. MF
GO:0050179 phenylserine aldolase activity Catalysis of the reaction: L-threo-3-phenylserine = glycine + benzaldehyde. MF
GO:0050178 phenylpyruvate tautomerase activity Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. MF
GO:0050177 phenylpyruvate decarboxylase activity Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2. MF
GO:0050176 phenylalanine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine. MF
GO:0050175 phenylalanine dehydrogenase activity Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH. MF
GO:0050174 phenylalanine decarboxylase activity Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2. MF
GO:0050173 phenylalanine adenylyltransferase activity Catalysis of the reaction: ATP + L-phenylalanine = diphosphate + N-adenylyl-L-phenylalanine. MF
GO:0050172 phenylalanine 2-monooxygenase activity Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O. MF
GO:0050171 phenol beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside. MF
GO:0050170 peptidyl-glutaminase activity Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3. MF
GO:0007078 lamin depolymerization The cell cycle process whereby lamin is depolymerized. BP
GO:0007079 mitotic chromosome movement towards spindle pole The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis. BP
GO:0007076 mitotic chromosome condensation The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells. BP
GO:0007077 mitotic nuclear envelope disassembly The cell cycle process whereby the controlled breakdown of the nuclear envelope during mitotic cell division occurs. BP
GO:0007074 activation of transcription on exit from mitosis, from RNA polymerase II promoter NA BP
GO:0007075 activation of transcription on exit from mitosis, from RNA polymerase III promoter NA BP
GO:0007072 activation of transcription on exit from mitosis The cell cycle process whereby transcription is positively regulated as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. BP
GO:0007073 activation of transcription on exit from mitosis, from RNA polymerase I promoter NA BP
GO:0007070 negative regulation of transcription from RNA polymerase II promoter, mitotic Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis. BP
GO:0007071 negative regulation of transcription from RNA polymerase III promoter, mitotic Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis. BP
GO:0052159 modulation by symbiont of induced systemic resistance in host Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052158 modulation by symbiont of host resistance gene-dependent defense response Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052153 positive regulation by symbiont of host non-apoptotic programmed cell death Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by a non-apoptotic pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052152 modulation by symbiont of host non-apoptotic programmed cell death Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by a non-apoptotic pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052151 positive regulation by symbiont of host apoptosis Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052150 modulation by symbiont of host apoptosis Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052157 modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity NA BP
GO:0052156 modulation by symbiont of host T-cell mediated immune response Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052155 modulation by symbiont of host cell-mediated immune response Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052154 modulation by symbiont of host B-cell mediated immune response Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0051387 negative regulation of nerve growth factor receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway. BP
GO:0051386 regulation of nerve growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway. BP
GO:0051385 response to mineralocorticoid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. BP
GO:0051384 response to glucocorticoid stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. BP
GO:0051382 kinetochore assembly The formation of the kinetochore, a multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules. BP
GO:0051381 histamine binding Interacting selectively with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. MF
GO:0051389 inactivation of MAPKK activity Any process that terminates the activity of the active enzyme MAP kinase kinase. BP
GO:0051388 positive regulation of nerve growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway. BP
GO:0010205 photoinhibition The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II. BP
GO:0010204 defense response signaling pathway, resistance gene-independent A series of molecular signals that is activated during defense response and does not depend upon R-genes. BP
GO:0010207 photosystem II assembly Formation of photosystem II complex on thylakoid membrane. In plants, the photosystem II complex consists of over 20 polypeptides encoded by either nuclear or chloroplast genome. BP
GO:0010206 photosystem II repair Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the Photosystem II following photoinhibition. BP
GO:0010201 response to high irradiance A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high irradiance stimulus, continuous exposure to low levels of far-red light for a prolonged period of time and is not far-red reversible. BP
GO:0010200 response to chitin A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus. BP
GO:0010203 response to very low fluence red light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Very low fluence red light is short pulses of very low fluence light followed by darkness, which occurs at light levels of less than 0.001 mmol/m2/sec red light and is not far-red reversible. BP
GO:0010202 response to low fluence red light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Low fluence red light is red light pulses followed by darkness, which occurs at red light levels of 0.001-0.1 mmol/m2/sec and is red/far-red reversible. BP
GO:0010209 vacuolar sorting signal binding Interacting selectively with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole. MF
GO:0010208 pollen wall formation The formation of reticulate pollen wall pattern consisting of two layers, exine and intine. BP
GO:0021713 inferior olivary nucleus development The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. BP
GO:0021712 candelabrum cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0021711 cerebellar unipolar brush cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex. BP
GO:0021710 cerebellar stellate cell differentiation The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. BP
GO:0021717 inferior olivary nucleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. BP
GO:0021716 inferior olivary nucleus structural organization The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. BP
GO:0021715 inferior olivary nucleus formation The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. BP
GO:0021714 inferior olivary nucleus morphogenesis The process by which the anatomical structure of the inferior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. BP
GO:0021719 superior olivary nucleus morphogenesis The process by which the anatomical structure of the superior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. BP
GO:0021718 superior olivary nucleus development The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. BP
GO:0015668 Type III site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites. MF
GO:0015669 gas transport The directed movement of substances that are gaseous in normal living conditions into, out of, within or between cells. BP
GO:0015660 formate efflux permease activity NA MF
GO:0015661 L-lysine exporter activity Catalysis of the stereospecific transfer of L-lysine, 2,6-diaminohexanoic acid, across a biological membrane out of a cell. MF
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. MF
GO:0015663 nicotinamide mononucleotide transporter activity Enables the directed movement of nicotinamide mononucleotide into, out of, within or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP. MF
GO:0015664 nicotinamide mononucleotide permease activity Catalysis of the transport of nicotinic acid across biological membranes. MF
GO:0015665 alcohol transporter activity Enables the directed movement of an alcohol, any carbon-containing compound containing a hydroxyl group, into, out of, within or between cells. MF
GO:0015666 restriction endodeoxyribonuclease activity Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. MF
GO:0015667 site-specific DNA-methyltransferase (cytosine-N4-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine. MF
GO:0016319 mushroom body development The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells. BP
GO:0016318 ommatidial rotation The process by which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification. BP
GO:0046309 1,3-dichloro-2-propanol biosynthetic process The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. BP
GO:0046308 Z-phenylacetaldoxime catabolic process The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds. BP
GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. BP
GO:0016310 phosphorylation The process of introducing a phosphoric group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. BP
GO:0016312 inositol bisphosphate phosphatase activity Catalysis of the removal of one of the two phosphate groups of an inositol bisphosphate. MF
GO:0046307 Z-phenylacetaldoxime biosynthetic process The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds. BP
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidyl inositol-4,5-bisphosphate + phosphate. MF
GO:0046305 alkanesulfonate biosynthetic process The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety. BP
GO:0046304 2-nitropropane catabolic process The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. BP
GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3. MF
GO:0030413 competence pheromone activity A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence. MF
GO:0030410 nicotianamine synthase activity Catalysis of the reaction: 3 S-adenosyl-L-methionine = 3 5'-S-methyl-5'-thioadenosine + nicotianamine. MF
GO:0030411 scytalone dehydratase activity Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O. MF
GO:0030416 methylamine metabolic process The chemical reactions and pathways involving methylamine (CH3NH2), a flammable, explosive gas, used in tanning and in organic synthesis and produced naturally in some decaying fish, certain plants, and crude methanol. BP
GO:0030417 nicotianamine metabolic process The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. BP
GO:0030414 protease inhibitor activity Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds. MF
GO:0030415 carboxypeptidase A inhibitor activity Stops, prevents or reduces the activity of the enzyme carboxypeptidase A. MF
GO:0030418 nicotianamine biosynthetic process The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. BP
GO:0030419 nicotianamine catabolic process The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. BP
GO:0047951 glutathione thiolesterase activity Catalysis of the reaction: S-acylglutathione + H2O = glutathione + a carboxylate. MF
GO:0047950 glutathione oxidase activity Catalysis of the reaction: 2 glutathione + O2 = oxidized glutathione + H2O2. MF
GO:0047953 glycerol 2-dehydrogenase (NADP+) activity Catalysis of the reaction: glycerol + NADP+ = glycerone + NADPH. MF
GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+. MF
GO:0047955 glycerol dehydrogenase (acceptor) activity Catalysis of the reaction: glycerol + acceptor = glycerone + reduced acceptor. MF
GO:0047954 glycerol-2-phosphatase activity Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate. MF
GO:0047957 isoflavone 2'-hydroxylase activity Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O. MF
GO:0047956 glycerol dehydrogenase (NADP+) activity Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH. MF
GO:0047959 glycine dehydrogenase (cytochrome) activity Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c. MF
GO:0047958 glycine transaminase activity Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate. MF
GO:0005861 troponin complex A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. CC
GO:0031455 glycine betaine metabolic process The chemical reactions and pathways involving glycine betaine, N-trimethylglycine. BP
GO:0031454 positive regulation of striated mixed muscle contraction Any process that activates or increases the frequency, rate or extent of striated mixed muscle contraction. BP
GO:0031457 glycine betaine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine. BP
GO:0031456 glycine betaine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine. BP
GO:0031451 positive regulation of striated slow muscle contraction Any process that activates or increases the frequency, rate or extent of striated slow muscle contraction. BP
GO:0031450 negative regulation of striated slow muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of striated slow muscle contraction. BP
GO:0031453 negative regulation of striated mixed muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of striated mixed muscle contraction. BP
GO:0031452 regulation of striated mixed muscle contraction Any process that modulates the frequency, rate or extent of striated mixed muscle contraction. BP
GO:0031459 glycine betaine-transporting ATPase activity Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in). MF
GO:0031458 betaine-transporting ATPase activity Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in). MF
GO:0009603 detection of symbiotic fungus The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal. BP
GO:0032226 positive regulation of synaptic transmission, dopaminergic Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. BP
GO:0032225 regulation of synaptic transmission, dopaminergic Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. BP
GO:0009600 detection of nematode The series of events in which a stimulus from a nematode is received and converted into a molecular signal. BP
GO:0032223 negative regulation of synaptic transmission, cholinergic Any process that stops, prevents or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. BP
GO:0009606 tropism The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it. BP
GO:0032221 Clr6 histone deacetylase complex A eukaryotically conserved histone deacetylse complex composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; homologs thereof in other species). CC
GO:0032220 plasma membrane fusion during cytogamy The joining of two or more lipid bilayer membranes that surround cells, during cytogamy. BP
GO:0009609 response to symbiotic bacterium A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism. BP
GO:0009608 response to symbiont A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0032229 negative regulation of synaptic transmission, GABAergic Any process that stops, prevents or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). BP
GO:0032228 regulation of synaptic transmission, GABAergic Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). BP
GO:0005232 serotonin-activated cation-selective channel activity NA MF
GO:0048620 post-embryonic hindgut morphogenesis The process by which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0005231 excitatory extracellular ligand-gated ion channel activity NA MF
GO:0005237 inhibitory extracellular ligand-gated ion channel activity NA MF
GO:0032483 regulation of Rab protein signal transduction Any process that modulates the frequency, rate or extent of Rab protein signal transduction. BP
GO:0032482 Rab protein signal transduction Any process that modulates the frequency, rate or extent of Rab protein signal transduction. BP
GO:0032481 positive regulation of interferon type I production Any process that activates or increases the frequency, rate, or extent of interferon type I production. BP
GO:0032480 negative regulation of interferon type I production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon type I production. BP
GO:0032487 regulation of Rap protein signal transduction Any process that modulates the frequency, rate or extent of Rap protein signal transduction. BP
GO:0032486 Rap protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state. BP
GO:0032485 regulation of Ral protein signal transduction Any process that modulates the frequency, rate or extent of Ral protein signal transduction. BP
GO:0032484 Ral protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state. BP
GO:0032489 regulation of Cdc42 protein signal transduction Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction. BP
GO:0032488 Cdc42 protein signal transduction A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state. BP
GO:0030885 regulation of myeloid dendritic cell activation Any process that modulates the frequency or rate of myeloid dendritic cell activation. BP
GO:0030884 exogenous lipid antigen binding Interacting selectively with an exogenous lipid antigen (examples include microbial lipids and glycolipids). MF
GO:0030887 positive regulation of myeloid dendritic cell activation Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation. BP
GO:0030886 negative regulation of myeloid dendritic cell activation Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell activation. BP
GO:0030881 beta-2-microglobulin binding Interacting selectively with beta-2-microglobulin. MF
GO:0030880 RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. CC
GO:0030883 endogenous lipid antigen binding Interacting selectively with an endogenous cellular lipid antigen. MF
GO:0030882 lipid antigen binding Interacting selectively with a lipid antigen. MF
GO:0030889 negative regulation of B cell proliferation Any process that stops, prevents or reduces the rate or extent of B cell proliferation. BP
GO:0030888 regulation of B cell proliferation Any process that modulates the frequency, rate or extent of B cell proliferation. BP
GO:0045629 negative regulation of T-helper 2 cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell differentiation. BP
GO:0045628 regulation of T-helper 2 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. BP
GO:0045621 positive regulation of lymphocyte differentiation Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. BP
GO:0045620 negative regulation of lymphocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte differentiation. BP
GO:0045623 negative regulation of T-helper cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper cell differentiation. BP
GO:0045622 regulation of T-helper cell differentiation Any process that modulates the frequency, rate or extent of T-helper cell differentiation. BP
GO:0045625 regulation of T-helper 1 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation. BP
GO:0045624 positive regulation of T-helper cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. BP
GO:0045627 positive regulation of T-helper 1 cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation. BP
GO:0045626 negative regulation of T-helper 1 cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell differentiation. BP
GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. MF
GO:0047172 shikimate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA. MF
GO:0047171 glucarolactone O-hydroxycinnamoyltransferase activity Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA. MF
GO:0047170 glucarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: D-glucarate + sinapoyl-CoA = O-sinapoylglucarate + CoA. MF
GO:0047177 glycerophospholipid arachidonoyl-transferase (CoA-independent) activity Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine. MF
GO:0047176 beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + beta-D-glucose. MF
GO:0047175 galactosylacylglycerol O-acyltransferase activity Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]. MF
GO:0047174 putrescine N-hydroxycinnamoyltransferase activity Catalysis of the reaction: putrescine + caffeoyl-CoA = N-caffeoylputrescine + CoA. MF
GO:0047179 platelet-activating factor acetyltransferase activity Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. MF
GO:0047178 glycerophospholipid acyltransferase (CoA-dependent) activity Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine. MF
GO:0006237 deoxycytidine salvage Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis. BP
GO:0006236 cytidine salvage Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis. BP
GO:0006235 dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. BP
GO:0006234 TTP biosynthetic process The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate. BP
GO:0006233 dTDP biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). BP
GO:0006232 TDP biosynthetic process The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate. BP
GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). BP
GO:0006230 TMP biosynthetic process The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate. BP
GO:0006239 dCMP salvage Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis. BP
GO:0006238 CMP salvage Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis. BP
GO:0048679 regulation of axon regeneration Any process that modulates the frequency, rate or extent of axon regeneration. BP
GO:0042127 regulation of cell proliferation Any process that modulates the frequency, rate or extent of cell proliferation. BP
GO:0047330 polyphosphate-glucose phosphotransferase activity Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate. MF
GO:0042125 protein amino acid galactosylation The addition of a galactose molecule to a protein amino acid. BP
GO:0047332 diphosphate-serine phosphotransferase activity Catalysis of the reaction: L-serine + pyrophosphate = phosphate + 3-phospho-serine. MF
GO:0047335 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate. MF
GO:0042122 alginic acid catabolic process The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). BP
GO:0042121 alginic acid biosynthetic process The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). BP
GO:0042120 alginic acid metabolic process The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). BP
GO:0032213 regulation of telomere maintenance via semi-conservative replication Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA. BP
GO:0009827 cell wall modification (sensu Magnoliophyta) The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0031868 prostaglandin F2-alpha receptor binding Interacting selectively with a prostaglandin F2-alpha receptor. MF
GO:0031869 prostacyclin receptor binding Interacting selectively with a prostacyclin receptor. MF
GO:0009826 unidimensional cell growth The process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis. BP
GO:0031864 EP1 subtype prostaglandin E2 receptor binding Interacting selectively with an EP1 subtype prostaglandin E2 receptor. MF
GO:0031865 EP2 subtype prostaglandin E2 receptor binding Interacting selectively with an EP2 subtype prostaglandin E2 receptor. MF
GO:0031866 EP3 subtype prostaglandin E2 receptor binding Interacting selectively with an EP3 subtype prostaglandin E2 receptor. MF
GO:0031867 EP4 subtype prostaglandin E2 receptor binding Interacting selectively with an EP4 subtype prostaglandin E2 receptor. MF
GO:0031860 telomeric 3' overhang formation The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans. BP
GO:0009825 multidimensional cell growth The process by which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes. BP
GO:0031862 prostanoid receptor binding Interacting selectively with a prostanoid receptor. MF
GO:0031863 prostaglandin D2 receptor binding Interacting selectively with a prostaglandin D2 receptor. MF
GO:0009824 adenylate dimethylallyltransferase activity Catalysis of the reaction: delta(2)-isopentenyl diphosphate + AMP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-monophosphate. MF
GO:0050759 positive regulation of thymidylate synthase biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. BP
GO:0050758 regulation of thymidylate synthase biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. BP
GO:0050757 thymidylate synthase biosynthetic process The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. BP
GO:0050756 fractalkine metabolic process The chemical reactions and pathways involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1. BP
GO:0050755 chemokine metabolic process The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. BP
GO:0050754 positive regulation of fractalkine biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. BP
GO:0050753 negative regulation of fractalkine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. BP
GO:0050752 regulation of fractalkine biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. BP
GO:0050751 fractalkine biosynthetic process The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1. BP
GO:0050750 low-density lipoprotein receptor binding Interacting selectively with a low density lipoprotein receptor. MF
GO:0043184 vascular endothelial growth factor receptor 2 binding Interacting selectively with vascular endothelial growth factor receptor 2. MF
GO:0009820 alkaloid metabolic process The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). BP
GO:0048914 myelination of anterior lateral line nerve axons The formation of compact myelin sheaths around the axons of the anterior lateral line nerve. BP
GO:0048915 posterior lateral line system development The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. BP
GO:0005766 primary lysosome A lysosome before it has fused with a vesicle or vacuole. CC
GO:0005767 secondary lysosome Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome. CC
GO:0005760 gamma DNA polymerase complex A heterodimer consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. CC
GO:0048911 efferent axon development in the anterior lateral line nerve The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve. BP
GO:0005762 mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). CC
GO:0048913 anterior lateral line nerve glial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve. BP
GO:0048918 posterior lateral line nerve development The process whose specific outcome is the progression of the posterior lateral line nerve over time, form its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. BP
GO:0005769 early endosome Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered. CC
GO:0004495 mevaldate reductase activity Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor. MF
GO:0004494 methylmalonyl-CoA mutase activity Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = succinyl-CoA. MF
GO:0004497 monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. MF
GO:0004496 mevalonate kinase activity Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. MF
GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. MF
GO:0004490 methylglutaconyl-CoA hydratase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O. MF
GO:0004493 methylmalonyl-CoA epimerase activity Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = (S)-2-methyl-3-oxopropanoyl-CoA. MF
GO:0004492 methylmalonyl-CoA decarboxylase activity Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2. MF
GO:0007616 long-term memory The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. BP
GO:0007617 mating behavior The actions or reactions of individuals for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. BP
GO:0007614 short-term memory The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. BP
GO:0007615 anesthesia-resistant memory NA BP
GO:0004499 dimethylaniline monooxygenase (N-oxide-forming) activity Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. MF
GO:0004498 calcidiol 1-monooxygenase activity Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. MF
GO:0007610 behavior The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. BP
GO:0007611 learning and/or memory The acquisition and processing of information and/or the storage and retrieval of this information over time. BP
GO:0002268 follicular dendritic cell differentiation The process whereby a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell. BP
GO:0002269 leukocyte activation during inflammatory response A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. BP
GO:0002260 lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. BP
GO:0002261 mucosal lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus. BP
GO:0002262 myeloid cell homeostasis The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. BP
GO:0002263 cell activation during immune response A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. BP
GO:0002264 endothelial cell activation during immune response A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. BP
GO:0002265 astrocyte activation during immune response A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. BP
GO:0002266 follicular dendritic cell activation A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. BP
GO:0002267 follicular dendritic cell activation during immune response A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. BP
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. MF
GO:0001516 prostaglandin biosynthetic process The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. BP
GO:0001515 opioid peptide activity Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. MF
GO:0001514 selenocysteine incorporation The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation, it is not a posttranslational modification of peptidyl-cysteine. BP
GO:0001512 dihydronicotinamide riboside quinone reductase activity NA MF
GO:0001510 RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in an polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. BP
GO:0001519 peptide amidation The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions. BP
GO:0001518 voltage-gated sodium channel complex A sodium channel in a cell membrane whose opening is governed by the membrane potential. CC
GO:0048008 platelet-derived growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. BP
GO:0048009 insulin-like growth factor receptor signaling pathway The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. BP
GO:0048002 antigen processing and presentation of peptide antigen The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. BP
GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib The process by which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. BP
GO:0048000 isoflavone 3'-hydroxylase activity Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O. MF
GO:0048001 erythrose-4-phosphate dehydrogenase activity Catalysis of the reaction: erythrose 4-phosphate + NAD+ = erythronate-4-phosphate + NADH + H+. A step in the pathway to 4-hydroxy-L-threonine, a precursor of pyridoxine. MF
GO:0048006 antigen processing and presentation, endogenous lipid antigen via MHC class Ib The process by which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. BP
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib The process by which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. BP
GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. MF
GO:0004148 dihydrolipoyl dehydrogenase activity Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. MF
GO:0004147 dihydrolipoamide branched chain acyltransferase activity NA MF
GO:0004146 dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. MF
GO:0004145 diamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. MF
GO:0004144 diacylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. MF
GO:0004143 diacylglycerol kinase activity Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate. MF
GO:0004142 diacylglycerol cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. MF
GO:0004141 dethiobiotin synthase activity Catalysis of the reaction: ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. MF
GO:0004140 dephospho-CoA kinase activity Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA. MF
GO:0019793 ISG15 carrier activity Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other. MF
GO:0019794 nonprotein amino acid metabolic process The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins. BP
GO:0019795 nonprotein amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins. BP
GO:0019796 nonprotein amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins. BP
GO:0019797 procollagen-proline 3-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. MF
GO:0019798 procollagen-proline dioxygenase activity Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a collagen molecule. MF
GO:0019799 tubulin N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine. MF
GO:0021551 central nervous system morphogenesis The process by which the anatomical structure of the central nervous system is generated and organized. Morphogenesis pertains to the creation of form. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. BP
GO:0021550 medulla oblongata development The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. BP
GO:0021553 olfactory nerve development The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. BP
GO:0021552 midbrain-hindbrain boundary structural organization The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. BP
GO:0021555 midbrain-hindbrain boundary morphogenesis The process by which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. Morphogenesis pertains to the creation of form. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. BP
GO:0021554 optic nerve development The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. BP
GO:0021557 oculomotor nerve development The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. BP
GO:0021556 central nervous system formation The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. BP
GO:0021559 trigeminal nerve development The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. BP
GO:0021558 trochlear nerve development The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. BP
GO:0050038 L-xylulose reductase activity Catalysis of the reaction: xylitol + NADP+ = L-xylulose + NADPH. MF
GO:0050039 lactaldehyde reductase (NADPH) activity Catalysis of the reaction: propane-1,2-diol + NADP+ = L-lactaldehyde + NADPH. MF
GO:0050032 L-rhamnonate dehydratase activity Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. MF
GO:0050033 L-rhamnono-1,4-lactonase activity Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate. MF
GO:0050030 L-pipecolate dehydrogenase activity Catalysis of the reaction: L-pipecolate + acceptor = 2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor. MF
GO:0050031 L-pipecolate oxidase activity Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2. MF
GO:0050036 L-threonate 3-dehydrogenase activity Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + NADH. MF
GO:0050037 L-xylose 1-dehydrogenase activity Catalysis of the reaction: L-xylose + NADP+ = L-xylono-1,4-lactone + NADPH. MF
GO:0050034 L-rhamnose 1-dehydrogenase activity Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamno-1,4-lactone + NADH. MF
GO:0050035 L-sorbose oxidase activity Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2. MF
GO:0051639 actin filament network formation The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments. BP
GO:0051638 barbed-end actin filament uncapping The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. BP
GO:0051633 positive regulation of acetylcholine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell. BP
GO:0051632 negative regulation of acetylcholine uptake Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell. BP
GO:0051631 regulation of acetylcholine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell. BP
GO:0051630 acetylcholine uptake The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. BP
GO:0051637 Gram-positive bacterial cell surface binding Interacting selectively with any component on the surface of a Gram-positive bacterium. MF
GO:0051636 Gram-negative bacterial cell surface binding Interacting selectively with any component on the surface of a Gram-negative bacterial cell. MF
GO:0051635 bacterial cell surface binding Interacting selectively with any component on the surface of a bacterial cell. MF
GO:0051634 inhibition of acetylcholine uptake Any process that prevents the activation of the directed movement of acetylcholine into a cell. BP
GO:0006178 guanine salvage Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis. BP
GO:0006179 guanosine salvage Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis. BP
GO:0006174 dADP phosphorylation The process of introducing a phosphoric group into dADP, deoxyadenosine diphosphate, to produce dATP. BP
GO:0006175 dATP biosynthetic process The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). BP
GO:0006176 dATP biosynthetic process from ADP The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate. BP
GO:0006177 GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. BP
GO:0006170 dAMP biosynthetic process The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). BP
GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). BP
GO:0006172 ADP biosynthetic process The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate. BP
GO:0006173 dADP biosynthetic process The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). BP
GO:0009728 detection of gibberellic acid stimulus The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal. BP
GO:0032345 negative regulation of aldosterone metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. BP
GO:0007564 regulation of cuticle tanning Any process that modulates the frequency, rate or extent of cuticular tanning. BP
GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. BP
GO:0015204 urea transporter activity Enables the directed movement of urea into, out of, within or between cells. Urea is the water soluble compound H2N-CO-NH2, produced in the liver via the ornithine-urea cycle. It is the main nitrogen-containing (urinary) excretion product in ureotelic animals. MF
GO:0015205 nucleobase transporter activity Enables the directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of, within or between cells. MF
GO:0015203 polyamine transporter activity Enables the directed movement of polyamines, organic compounds containing two or more amino groups, into, out of, within or between cells. MF
GO:0015200 methylammonium transporter activity Enables the directed movement of methylammonium, CH3NH2, into, out of, within or between cells. MF
GO:0047771 carboxymethylhydantoinase activity Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate. MF
GO:0047770 carboxylate reductase activity Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor. MF
GO:0047773 carnitinamidase activity Catalysis of the reaction: L-carnitinamide + H2O = L-carnitine + NH3. MF
GO:0047772 carboxymethyloxysuccinate lyase activity Catalysis of the reaction: O2 + 2 carboxymethyloxysuccinate = 2 glycolate + 2 fumarate. MF
GO:0047775 citramalate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA. MF
GO:0047774 cis-2-enoyl-CoA reductase (NADPH) activity Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH. MF
GO:0047777 citramalyl-CoA lyase activity Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate. MF
GO:0047776 citramalate lyase activity Catalysis of the reaction: (3S)-citramalate = acetate + pyruvate. MF
GO:0047779 citrate-CoA ligase activity Catalysis of the reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA. MF
GO:0047778 [citrate-(pro-3S)-lyase] thiolesterase activity Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate. MF
GO:0043461 F-type ATPase complex assembly The aggregation and bonding together of F-type ATPase, a multi-subunit proton-transporting ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. BP
GO:0016439 tRNA-pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. MF
GO:0043463 regulation of rhamnose catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. BP
GO:0043462 regulation of ATPase activity Any process that modulates the rate of ATP hydrolysis by an ATPase. BP
GO:0043465 regulation of fermentation Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP). BP
GO:0043464 malolactic fermentation The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP. BP
GO:0043467 regulation of generation of precursor metabolites and energy Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. BP
GO:0043466 pyrimidine fermentation The anaerobic conversion of pyrimidines, yielding energy in the form of ATP. BP
GO:0016430 tRNA (adenine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. MF
GO:0016431 tRNA (uridine) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a uridine residue in a tRNA molecule. MF
GO:0016432 tRNA-uridine aminocarboxypropyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine. MF
GO:0016433 rRNA (adenine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule. MF
GO:0016434 rRNA (cytosine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in an rRNA molecule. MF
GO:0016435 rRNA (guanine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in an rRNA molecule. MF
GO:0016436 rRNA (uridine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a uridine residue in an rRNA molecule. MF
GO:0016437 tRNA cytidylyltransferase activity Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1). MF
GO:0009175 pyrimidine ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009177 pyrimidine deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0050264 rifamycin-B oxidase activity Catalysis of the reaction: rifamycin B + O2 = rifamycin O + H2O2. MF
GO:0009171 purine deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009170 purine deoxyribonucleoside monophosphate metabolic process The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009172 purine deoxyribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0030603 oxaloacetase activity Catalysis of the reaction: oxaloacetate + H2O = oxalate + acetate. MF
GO:0030602 chymosin activity Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein. MF
GO:0030601 aminopeptidase B activity Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys. MF
GO:0030600 feruloyl esterase activity Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide. MF
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; catalyzes the formation of 2-C-methyl-D-erythritol from 1-deoxy-D-xylulose-5-phosphate as the second step in the non-mevalonate pathway for terpenoid synthesis. MF
GO:0045049 protein insertion into ER membrane by N-terminal cleaved signal sequence The insertion of integral proteins into the endoplasmic reticulum membrane. N-terminal cleaved signal sequences direct polypeptides to the ER. BP
GO:0045048 protein insertion into ER membrane The process by which a protein is incorporated into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. BP
GO:0045041 protein import into mitochondrial intermembrane space The import of proteins into the space between the inner and outer mitochondrial membranes. BP
GO:0045040 protein import into mitochondrial outer membrane The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane. BP
GO:0045043 protein import into mitochondrial intermembrane space, nonconservative The nonconservative import of proteins into the mitochondrial intermembrane space. The protein enters the intermembrane space and an uptake-targeting sequence functions as a stop-transfer sequence, blocking translocation of the C-terminus of the protein through the inner membrane. Cleavage of the uptake-targeting sequence by a protease in the intermembrane space releases the protein into the IMS. BP
GO:0045042 protein import into mitochondrial intermembrane space, conservative The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space. BP
GO:0045045 secretory pathway The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane. BP
GO:0045044 protein import into mitochondrial intermembrane space, direct Import of proteins directly into the mitochondrial intermembrane space without the assistance of any targeting signals. A conformational change ensures that the protein cannot diffuse back through the outer-membrane channels. BP
GO:0045047 protein targeting to ER The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. BP
GO:0045046 protein import into peroxisome membrane The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import. BP
GO:0018829 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. MF
GO:0018828 halohydrin hydrogen-halide-lyase A activity Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane. MF
GO:0018825 triethanolamine lyase activity Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde. MF
GO:0018824 hydroxylaminobenzene mutase activity Catalysis of the reaction: hydroxylaminobenzene = 2-aminophenol. MF
GO:0018827 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU. MF
GO:0018826 methionine gamma-lyase activity Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate. MF
GO:0018820 cyanamide hydratase activity Catalysis of the reaction: urea = cyanamide + H2O. MF
GO:0018823 cyclohexa-1,5-dienecarbonyl-CoA hydratase activity Catalysis of the reaction: cyclohex-1,5-dienecarbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA. MF
GO:0018822 nitrile hydratase activity Catalysis of the reaction: an aliphatic amide = a nitrile + H2O. MF
GO:0002448 mast cell mediated immunity Any process involved in the carrying out of an immune response by a mast cell. BP
GO:0002449 lymphocyte mediated immunity Any process involved in the carrying out of an immune response by a lymphocyte. BP
GO:0002440 production of molecular mediator of immune response The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002441 histamine secretion during acute inflammatory response The regulated release of histamine by a cell or group of cells during an acute inflammatory response. BP
GO:0002442 serotonin secretion during acute inflammatory response The regulated release of serotonin by a cell or group of cells during an acute inflammatory response. BP
GO:0002443 leukocyte mediated immunity Any process involved in the carrying out of an immune response by a leukocyte. BP
GO:0002444 myeloid leukocyte mediated immunity Any process involved in the carrying out of an immune response by a myeloid leukocyte. BP
GO:0002445 type II hypersensitivity An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors. BP
GO:0002446 neutrophil mediated immunity Any process involved in the carrying out of an immune response by a neutrophil. BP
GO:0002447 eosinophil mediated immunity Any process involved in the carrying out of an immune response by an eosinophil. BP
GO:0042088 T-helper 1 type immune response An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. BP
GO:0042089 cytokine biosynthetic process The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. BP
GO:0042084 5-methyltetrahydrofolate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate. MF
GO:0042085 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate. MF
GO:0042086 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin. MF
GO:0042081 GSI anchor metabolic process The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane. BP
GO:0042082 GSI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid moiety is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage. BP
GO:0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate. MF
GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. BP
GO:0006376 mRNA splice site selection Selection of a splice site by components of the assembling spliceosome. BP
GO:0006374 nuclear mRNA splicing via U2-type spliceosome The cleavage and rejoining of a primary nuclear mRNA transcript to remove sequences not present in the mature form of the RNA via a U2-type spliceosome. BP
GO:0006375 nuclear mRNA splicing via U12-type spliceosome The cleavage and rejoining of a primary nuclear mRNA transcript to remove sequences not present in the mature form of the RNA via a U12-type spliceosome. BP
GO:0006378 mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. BP
GO:0006379 mRNA cleavage Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. BP
GO:0042556 eukaryotic elongation factor-2 kinase regulator activity Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase. MF
GO:0042557 eukaryotic elongation factor-2 kinase activator activity Increases the activity of the enzyme eukaryotic elongation factor-2 kinase. MF
GO:0042554 superoxide release The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. BP
GO:0042555 MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication. CC
GO:0042552 myelination The process by which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. BP
GO:0042550 photosystem I stabilization The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. BP
GO:0042551 neuron maturation A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. BP
GO:0042558 pteridine and derivative metabolic process The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. BP
GO:0042559 pteridine and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. BP
GO:0005135 interleukin-3 receptor binding Interacting selectively with the interleukin-3 receptor. MF
GO:0005134 interleukin-2 receptor binding Interacting selectively with the interleukin-2 receptor. MF
GO:0005137 interleukin-5 receptor binding Interacting selectively with the interleukin-5 receptor. MF
GO:0005136 interleukin-4 receptor binding Interacting selectively with the interleukin-4 receptor. MF
GO:0048701 embryonic cranial skeleton morphogenesis The process by which the anatomical structures of cranial skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. BP
GO:0005130 granulocyte colony-stimulating factor receptor binding Interacting selectively with the granulocyte colony-stimulating factor receptor. MF
GO:0048703 embryonic viscerocranium morphogenesis The process by which the anatomical structures of viscerocranium are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The viscerocranium is the part of the skull comprising the facial bones. BP
GO:0005132 interferon-alpha/beta receptor binding Interacting selectively with the interferon-alpha/beta receptor. MF
GO:0005139 interleukin-7 receptor binding Interacting selectively with the interleukin-7 receptor. MF
GO:0005138 interleukin-6 receptor binding Interacting selectively with the interleukin-6 receptor. MF
GO:0004848 ureidoglycolate hydrolase activity Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2. MF
GO:0004849 uridine kinase activity Catalysis of the reaction: ATP + uridine = ADP + UMP. MF
GO:0004846 urate oxidase activity Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2. MF
GO:0004847 urea carboxylase activity Catalysis of the reaction: ATP + urea + CO2 = ADP + phosphate + urea-1-carboxylate. MF
GO:0004844 uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. MF
GO:0004845 uracil phosphoribosyltransferase activity Catalysis of the reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0004842 ubiquitin-protein ligase activity Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Catalyzes the mediation of substrate recognition in ubiquitin-mediated protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme). MF
GO:0004843 ubiquitin-specific protease activity Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups. MF
GO:0004840 ubiquitin conjugating enzyme activity Catalysis of the linkage of ubiquitin with lysine residues on a target protein. This function may be performed alone or in conjunction with E3, ubiquitin-protein ligase. MF
GO:0050658 RNA transport The directed movement of RNA, ribonucleic acids, into, out of, within or between cells. BP
GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine 4-sulfate (in chondroitin sulfate) = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4,6-bissulfate. Functions on nonreducing terminal and internal GalNAc(4SO(4)) residues contained in chondroitin sulfate A and dermatan sulfate (chondroitin sulfate B). MF
GO:0050652 dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate. BP
GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate. BP
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. BP
GO:0050651 dermatan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. BP
GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding Interacting selectively with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. MF
GO:0050657 nucleic acid transport The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of, within or between cells. BP
GO:0050654 chondroitin sulfate proteoglycan metabolic process The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. BP
GO:0050655 dermatan sulfate proteoglycan metabolic process The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. BP
GO:0051019 mitogen-activated protein kinase binding Interacting selectively with a mitogen-activated protein kinase. MF
GO:0051018 protein kinase A binding Interacting selectively with protein kinase A. MF
GO:0051013 microtubule severing The process by which a microtubule is broken down into smaller segments. BP
GO:0051012 microtubule sliding The movement of one microtubule along another microtubule. BP
GO:0051011 microtubule minus-end binding Interacting selectively with the minus end of a microtubule. MF
GO:0004261 cathepsin G activity Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C. MF
GO:0051017 actin filament bundle formation The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. BP
GO:0051016 barbed-end actin filament capping The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. BP
GO:0051015 actin filament binding Interacting selectively with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. MF
GO:0051014 actin filament severing The process by which an actin filament is broken down into smaller filaments. BP
GO:0010179 IAA-Ala conjugate hydrolase activity Catalysis of the reaction: IAA-alanine -> indole-3-acetic acid + alanine. MF
GO:0010178 IAA-amino acid conjugate hydrolase activity Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid. MF
GO:0007409 axonogenesis Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. BP
GO:0007407 neuroblast activation A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. BP
GO:0007406 negative regulation of neuroblast proliferation Any process that stops, prevents or reduces the frequency, rate or extent of the proliferation of neuroblasts. BP
GO:0007405 neuroblast proliferation The rapid expansion of a neuroblast population by cell division. Neuroblasts are embryonic cells that develop into nerve cells or neurons. BP
GO:0010170 glucose-1-phosphate adenylyltransferase complex Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits. CC
GO:0007403 glial cell fate determination Process by which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0007402 ganglion mother cell fate determination Process by which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0010175 sphingosine transporter activity Enables the directed movement of the amino alcohol sphingosine into, out of, within, or between cells. MF
GO:0007400 neuroblast fate determination Process by which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0018366 L-amino acid racemization The formation of a mixture of the two possible enantiomers from the L-isomer of a chiral amino acid. BP
GO:0018364 peptidyl-glutamine methylation NA BP
GO:0018365 protein-serine epimerase activity Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine. MF
GO:0018362 peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester. BP
GO:0018363 peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium. BP
GO:0018360 protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine. BP
GO:0018361 peptidyl-glutamine 2-methylation The methylation of glutamine to form 2-methyl-L-glutamine. BP
GO:0001725 stress fiber Bundle of microfilaments and other proteins found in fibroblasts. CC
GO:0001726 ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. CC
GO:0001727 lipid kinase activity Catalysis of the phosphorylation of a simple or complex lipid. MF
GO:0001720 conversion of lysyl-tRNA to pyrrolysyl-tRNA Process whereby lysine carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon) is converted to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate). BP
GO:0001729 ceramide kinase activity Catalysis of the reaction: ATP + ceramide = ADP + ceramide 1-phosphate. MF
GO:0018588 tri-n-butyltin dioxygenase activity Catalysis of the reaction: tri-n-butyltin (TBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin. MF
GO:0018589 di-n-butyltin dioxygenase activity Catalysis of the reaction: dibutyltin (DBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin. MF
GO:0018582 1-hydroxy-2-naphthoate 1,2-dioxygenase activity Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate. MF
GO:0018583 biphenyl-2,3-diol 1,2-dioxygenase activity Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O. MF
GO:0018580 2-nitropropane dioxygenase activity Catalysis of the reaction: 2 2-nitropropane + O2 = 2 acetone + 2 NO2(-) (nitrite). MF
GO:0018581 hydroxyquinol 1,2-dioxygenase activity Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate. MF
GO:0018586 mono-butyltin dioxygenase activity Catalysis of the reaction: butyltin (MBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin. MF
GO:0018587 limonene 8-monooxygenase activity NA MF
GO:0018584 2,4,5-trichlorophenoxyacetic acid oxygenase activity Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol. MF
GO:0018585 fluorene oxygenase activity Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol. MF
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. MF
GO:0016636 oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. MF
GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. MF
GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound. MF
GO:0016632 oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome. MF
GO:0016633 galactonolactone dehydrogenase activity Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. MF
GO:0016630 protochlorophyllide reductase activity Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+. MF
GO:0016631 enoyl-[acyl-carrier-protein] reductase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. MF
GO:0004347 glucose-6-phosphate isomerase activity Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. MF
GO:0015765 methylgalactoside transport The directed movement of methylgalactoside into, out of, within or between cells. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. BP
GO:0042469 versicolorin reductase activity Catalysis of the reduction of versicolorin A to sterigmatocystin. MF
GO:0015764 N-acetylglucosamine transport Enables the directed movement of N-acetylglucosamine into, out of, within or between cells. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein. BP
GO:0015767 lactose transport The directed movement of lactose into, out of, within or between cells. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. BP
GO:0052092 positive regulation by symbiont of nutrient release from host Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052093 formation by symbiont of specialized structure for nutrient acquisition from host The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052090 modulation by symbiont of defense-related host callose deposition Any process by which an organism modulates the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0015766 disaccharide transport The directed movement of disaccharides into, out of, within or between cells. Disaccharides are sugars composed of two monosaccharide units. BP
GO:0052096 formation by symbiont of syncytium involving giant cell for nutrient acquisition from host NA BP
GO:0052097 interspecies quorum sensing The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules. BP
GO:0052094 formation by symbiont of haustorium for nutrient acquisition from host The assembly by an organism of a haustorium, a projection from a cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052095 formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0015761 mannose transport The directed movement of mannose into, out of, within or between cells. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. BP
GO:0052098 formation by host of specialized structure for nutrient acquisition from symbiont The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052099 acquisition by symbiont of nutrients from host via siderophores NA BP
GO:0015760 glucose-6-phosphate transport The directed movement of glucose-6-phosphate into, out of, within or between cells. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. BP
GO:0016180 snRNA processing Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. BP
GO:0016182 endosome to synaptic vesicle budding Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes. BP
GO:0016183 synaptic vesicle coating A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. BP
GO:0016185 synaptic vesicle budding Formation of a new synaptic vesicle from the presynaptic membrane. BP
GO:0016188 synaptic vesicle maturation Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle. BP
GO:0016189 synaptic vesicle to endosome fusion Fusion of a synaptic vesicle with the membrane of an endosome. BP
GO:0015762 rhamnose transport The directed movement of rhamnose into, out of, within or between cells. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. BP
GO:0019181 halohydrin hydrogen-halide-lyase activity NA MF
GO:0019180 dTDP-4-amino-4,6-dideoxygalactose transaminase activity Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate. MF
GO:0019183 histamine-gated chloride channel complex NA CC
GO:0019182 histamine-gated chloride channel activity NA MF
GO:0019185 snRNA-activating protein complex A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters. CC
GO:0019184 nonribosomal peptide biosynthetic process The process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. BP
GO:0019187 beta-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an beta-1,4-linkage. MF
GO:0019186 acyl-CoA N-acyltransferase activity NA MF
GO:0019189 lactose permease activity NA MF
GO:0019188 sucrose permease (PTS) activity NA MF
GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. BP
GO:0016498 neuromedin K receptor activity Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity. MF
GO:0008872 glucarate dehydratase activity Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. MF
GO:0016499 orexin receptor activity Combining with orexin to initiate a change in cell activity. MF
GO:0006855 multidrug transport The directed movement of drugs into, out of, within or between cells. BP
GO:0006853 carnitine shuttle The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine. BP
GO:0006851 mitochondrial calcium ion transport The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion. BP
GO:0006850 mitochondrial pyruvate transport The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion. BP
GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP. BP
GO:0007189 G-protein signaling, adenylate cyclase activating pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP. BP
GO:0016490 structural constituent of peritrophic membrane (sensu Insecta) The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). MF
GO:0007182 common-partner SMAD protein phosphorylation NA BP
GO:0007183 SMAD protein complex assembly The aggregation and bonding together of a set of components to form a protein complex that contains SMAD proteins. BP
GO:0050220 prostaglandin-E synthase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate. MF
GO:0043408 regulation of MAPKKK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. BP
GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. BP
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. BP
GO:0007184 SMAD protein nuclear translocation NA BP
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand. BP
GO:0051848 active evasion of symbiont immune response via regulation of symbiont cytokine network Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051849 active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051840 negative regulation by host of cytolysis of symbiont cells Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051841 positive regulation by host of cytolysis of symbiont cells Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051843 evasion or tolerance of symbiont defense response Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051844 translocation of peptides or proteins into symbiont The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051845 passive evasion of symbiont immune response Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051846 active evasion of symbiont immune response Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0051847 active evasion of symbiont immune response via regulation of symbiont complement system Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0008728 GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. MF
GO:0008723 DNA polymerase V activity NA MF
GO:0008721 D-serine ammonia-lyase activity Catalysis of the reaction: D-serine = pyruvate + NH3. MF
GO:0008720 D-lactate dehydrogenase activity Catalysis of the reaction: (R)-lactate + NAD+ = pyruvate + NADH + H+. MF
GO:0008727 GDP-mannose mannosyl hydrolase activity NA MF
GO:0008726 alkanesulfonate monooxygenase activity Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + SO3(2-) (sulfite) + H2O + FMN. MF
GO:0008725 DNA-3-methyladenine glycosylase I activity Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. MF
GO:0045470 R8-mediated photoreceptor organization The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor. BP
GO:0045471 response to ethanol A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. BP
GO:0045472 response to ether A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. BP
GO:0045475 locomotor rhythm The rhythm of the locomotor activity of an organism during its 24 hour activity cycle. BP
GO:0045476 nurse cell apoptosis The process by which nurse cells undergo apoptosis. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptosis. BP
GO:0045477 regulation of nurse cell apoptosis Any process that modulates the frequency, rate or extent of nurse cell apoptosis. BP
GO:0045478 fusome organization and biogenesis The assembly and arrangement of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells. BP
GO:0045479 vesicle targeting to fusome The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome. BP
GO:0035150 regulation of tube size Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development in order to maintain functionality as the animal grows. BP
GO:0035151 regulation of tracheal tube size Ensuring that an epithelial tracheal tube is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape. BP
GO:0035152 regulation of tracheal tube architecture Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network. BP
GO:0035153 tracheal epithelial cell type specification Allocation of cells within each migrating tracheal branch to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions. BP
GO:0035154 terminal cell fate specification Process by which a cell becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange. BP
GO:0035155 negative regulation of terminal cell fate specification Any process that restricts, stops or prevents a cell from adopting a terminal cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. BP
GO:0035156 fusion cell fate specification Process by which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion. BP
GO:0035157 negative regulation of fusion cell fate specification Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. BP
GO:0035158 regulation of tracheal tube diameter Ensuring that a tracheal tube is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size. BP
GO:0035159 regulation of tracheal tube length Ensuring that a tracheal tube is of the correct length. BP
GO:0046419 octopine metabolic process The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine. BP
GO:0046418 nopaline metabolic process The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative. BP
GO:0046413 organomercury catabolic process The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom. BP
GO:0046412 phenylmercury acetate metabolic process The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group. BP
GO:0046411 2-keto-3-deoxygluconate transport The directed movement of 2-keto-3-deoxygluconate into, out of, within or between cells. BP
GO:0046410 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2. MF
GO:0046417 chorismate metabolic process The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. BP
GO:0046416 D-amino acid metabolic process The chemical reactions and pathways involving D-amino acids, the dextrorotatory isomers of amino acids. BP
GO:0046415 urate metabolic process The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. BP
GO:0046414 organomercury biosynthetic process The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom. BP
GO:0043168 anion binding Interacting selectively with anions, charged atoms or groups of atoms with a net negative charge. MF
GO:0043169 cation binding Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge. MF
GO:0009809 lignin biosynthetic process The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. BP
GO:0009808 lignin metabolic process The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units. BP
GO:0009805 coumarin biosynthetic process The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. BP
GO:0009804 coumarin metabolic process The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. BP
GO:0009807 lignan biosynthetic process The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. BP
GO:0009806 lignan metabolic process The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. BP
GO:0009801 cinnamic acid ester metabolic process The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid. BP
GO:0009800 cinnamic acid biosynthetic process The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid. BP
GO:0009803 cinnamic acid metabolic process The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid. BP
GO:0009802 cinnamic acid ester biosynthetic process The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid. BP
GO:0042417 dopamine metabolic process The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. BP
GO:0042416 dopamine biosynthetic process The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. BP
GO:0042415 norepinephrine metabolic process The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. BP
GO:0042414 epinephrine metabolic process The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. BP
GO:0042413 carnitine catabolic process The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. BP
GO:0042412 taurine biosynthetic process The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. BP
GO:0042411 beta-carotene hydroxylase activity Catalysis of the hydroxylation of both beta rings of beta-carotene to form zeaxanthine. MF
GO:0042410 6-carboxyhexanoate-CoA ligase activity Catalysis of the reaction: ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA. MF
GO:0042419 epinephrine catabolic process The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. BP
GO:0042418 epinephrine biosynthetic process The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. BP
GO:0048549 positive regulation of pinocytosis Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. BP
GO:0048548 regulation of pinocytosis Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. BP
GO:0048543 phytochrome chromophore biosynthetic process The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form. BP
GO:0048542 lymph gland development (sensu Arthropoda) The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656). BP
GO:0048541 Peyer's patch development The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. BP
GO:0048540 bursa development The process whose specific outcome is the progression of the bursa over time, from its formation to the mature structure. The bursa is an organ found in birds involved in B cell differentiation. BP
GO:0048547 gut morphogenesis The process by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. BP
GO:0048546 digestive tract morphogenesis The process by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines. BP
GO:0048545 response to steroid hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. BP
GO:0048544 recognition or rejection of self pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. BP
GO:0048811 male analia morphogenesis (sensu Endopterygota) The process by which the anatomical structures of the analia of the male are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048810 female analia morphogenesis (sensu Endopterygota) The process by which the anatomical structures of the analia of the female are generated and organized. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0048813 dendrite morphogenesis The process by which the anatomical structures of dendrite are generated and organized. Morphogenesis pertains to the creation of form. A dendrite is a freely branching protoplasmic process of a nerve cell. BP
GO:0002050 pyoverdine catabolic process The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine. BP
GO:0048815 hermaphrodite genitalia morphogenesis The process by which the anatomical structures of hermaphrodite genitalia are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048814 regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis. BP
GO:0002055 adenine binding Interacting selectively with adenine, a purine base. MF
GO:0048816 ocellus morphogenesis The process by which the anatomical structures of the ocellus are generated and organized. Morphogenesis pertains to the creation of form. The ocellus is a simple visual organ of insects. BP
GO:0009113 purine base biosynthetic process The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. BP
GO:0005009 insulin receptor activity Combining with insulin to initiate a change in cell activity. MF
GO:0009111 vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. BP
GO:0009110 vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. BP
GO:0009117 nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). BP
GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). BP
GO:0009115 xanthine catabolic process The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids. BP
GO:0009114 hypoxanthine catabolic process The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. BP
GO:0050245 quercitrinase activity Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin. MF
GO:0050244 pyruvate oxidase (CoA-acetylating) activity Catalysis of the reaction: pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2. MF
GO:0050247 raucaffricine beta-glucosidase activity Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine. MF
GO:0009118 regulation of nucleoside metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. BP
GO:0050241 pyrroline-2-carboxylate reductase activity Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+. MF
GO:0050240 pyrogallol 1,2-oxygenase activity Catalysis of the reaction: 1,2,3-trihydroxybenzene + O2 = (Z)-5-oxohex-2-enedioate. MF
GO:0050243 pyruvate dehydrogenase (NADP+) activity Catalysis of the reaction: pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH. MF
GO:0050242 pyruvate, phosphate dikinase activity Catalysis of the reaction: ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate. MF
GO:0032393 MHC class I receptor activity Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. MF
GO:0032392 DNA geometric change The process by which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. BP
GO:0032391 photoreceptor connecting cilium A 9+0 cilium that forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments. CC
GO:0032390 MutLbeta complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1. CC
GO:0032397 activating MHC class I receptor activity Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte. MF
GO:0032396 inhibitory MHC class I receptor activity Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. MF
GO:0032395 MHC class II receptor activity Combining with an MHC class II protein complex to initiate a change in cellular activity. MF
GO:0032394 MHC class Ib receptor activity Combining with an MHC class Ib protein complex to initiate a change in cellular activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. MF
GO:0032399 HECT domain binding Interacting selectively with a HECT, 'Homologous to the E6-AP Carboxyl Terminus', domain of a protein. MF
GO:0032398 MHC class Ib protein complex A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. CC
GO:0019347 GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate. BP
GO:0019346 transsulfuration The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. BP
GO:0019345 cysteine biosynthetic process via S-sulfo-L-cysteine The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine. BP
GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. BP
GO:0019343 cysteine biosynthetic process via cystathione The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathione. BP
GO:0019342 trypanothione biosynthetic process The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress. BP
GO:0019341 dibenzo-p-dioxin catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. BP
GO:0019340 dibenzofuran catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. BP
GO:0019349 ribitol metabolic process The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin. BP
GO:0019348 dolichol metabolic process The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. BP
GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. BP
GO:0032644 regulation of fractalkine production Any process that modulates the frequency, rate, or extent of fractalkine production. BP
GO:0032647 regulation of interferon-alpha production Any process that modulates the frequency, rate, or extent of interferon-alpha production. BP
GO:0032646 regulation of hepatocyte growth factor production Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production. BP
GO:0032641 tumor necrosis factor-beta production The appearance of tumor necrosis factor-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032640 tumor necrosis factor-alpha production The appearance of tumor necrosis factor-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032643 regulation of connective tissue growth factor production Any process that modulates the frequency, rate, or extent of connective tissue growth factor production. BP
GO:0032642 regulation of chemokine production Any process that modulates the frequency, rate, or extent of chemokine production. BP
GO:0032649 regulation of interferon-gamma production Any process that modulates the frequency, rate, or extent of interferon-gamma production. BP
GO:0032648 regulation of interferon-beta production Any process that modulates the frequency, rate, or extent of interferon-beta production. BP
GO:0010289 homogalacturonan biosynthetic process The formation from simpler components of the pectidic homogalacturonan, charaterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. BP
GO:0010288 response to lead ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. BP
GO:0010285 L,L-diaminopimelate aminotransferase activity Catalysis of the reaction: tetrahydrodipicolinate + glutamate = L,L-diaminopimelate + 2-oxoglutarate. MF
GO:0010284 lariciresinol reductase activity Catalysis of the reaction: lariciresinol + NADPH = secoisolariciresinol + NADP+. MF
GO:0010287 plastoglobule Plastoglobules (PG) are lipoprotein particles present in chloroplasts. They are rich in non-polar lipids (triacylglycerols, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids. CC
GO:0010286 heat acclimation Processes that increase heat tolerance of an organism in response to high temperatures. BP
GO:0010281 acyl-ACP thioesterase activity Catalysis of the reaction: acyl-ACP + H2O = a fatty acid + ACP. MF
GO:0010280 UDP-L-rhamnose synthase activity Catalysis of the reaction UDP-D-glucose + NADPH = UDP-L-rhamnose + NADP+ + H2O. MF
GO:0010283 pinoresinol reductase activity Catalysis of the reaction: pinoresinol + NADPH = lariciresinol + NADP+. MF
GO:0010282 senescence associated vacuole Vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast. CC
GO:0001100 negative regulation of exit from mitosis Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). BP
GO:0001101 response to acid A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus. BP
GO:0006655 phosphatidylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. BP
GO:0006654 phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. BP
GO:0006657 CDP-choline pathway The formation of phosphatidylcholines via the combination of CDP-choline with diacylglycerol. BP
GO:0006656 phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. BP
GO:0006651 diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. BP
GO:0006650 glycerophospholipid metabolic process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. BP
GO:0006653 lecithin metabolic process The chemical reactions and pathways involving lecithin, any 3-sn-phosphatidylcholine. BP
GO:0006652 alpha-glycerophosphate pathway NA BP
GO:0006659 phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. BP
GO:0006658 phosphatidylserine metabolic process The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. BP
GO:0046883 regulation of hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells. BP
GO:0018285 iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide. BP
GO:0018284 iron incorporation into protein via tetrakis-L-cysteinyl iron The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein). BP
GO:0018287 iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide. BP
GO:0005309 creatine:sodium symporter activity Catalysis of the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). MF
GO:0018281 GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. BP
GO:0018280 protein amino acid S-linked glycosylation The posttranslational glycosylation of protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine. BP
GO:0018283 iron incorporation into metallo-sulfur cluster The incorporation of iron into a metallo-sulfur cluster. BP
GO:0018282 metal incorporation into metallo-sulfur cluster The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide. BP
GO:0005302 L-tyrosine transporter activity Enables the directed movement of L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of, within or between cells. MF
GO:0005300 high-affinity tryptophan transporter activity NA MF
GO:0018289 molybdenum incorporation into metallo-sulfur cluster The incorporation of molybdenum into a metallo-sulfur cluster. BP
GO:0018288 iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide. BP
GO:0005304 L-valine transporter activity Enables the directed movement of L-valine, 2-amino-3-methylbutanoic acid, into, out of, within or between cells. MF
GO:0000769 syncytium formation by mitosis without cell division The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cell division. BP
GO:0000768 syncytium formation by plasma membrane fusion The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. BP
GO:0000767 cellular morphogenesis during conjugation The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types. BP
GO:0000766 adaptation to pheromone during pheromone-induced unidirectional conjugation In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses. BP
GO:0000765 response to pheromone during pheromone-induced unidirectional conjugation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of pheromone-induced unidirectional conjugation. BP
GO:0000764 cellular morphogenesis during pheromone-induced unidirectional conjugation The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation. BP
GO:0000763 cellular morphogenesis during unidirectional conjugation The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation. BP
GO:0000762 pheromone-induced unidirectional conjugation The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. BP
GO:0000761 conjugant formation During conjugation without cellular fusion, the processes involved in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing. BP
GO:0000760 adaptation to pheromone during conjugation without cellular fusion In organisms that undergo conjugation without cellular fusion, the processes involved in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. BP
GO:0004659 prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). MF
GO:0004658 propionyl-CoA carboxylase activity Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. MF
GO:0004657 proline dehydrogenase activity Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. MF
GO:0004656 procollagen-proline 4-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. MF
GO:0004655 porphobilinogen synthase activity Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. MF
GO:0004654 polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1). MF
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. MF
GO:0004652 polynucleotide adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. MF
GO:0004651 polynucleotide 5'-phosphatase activity Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. MF
GO:0004650 polygalacturonase activity Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. MF
GO:0051196 regulation of coenzyme metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. BP
GO:0051197 positive regulation of coenzyme metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. BP
GO:0051194 positive regulation of cofactor metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. BP
GO:0051195 negative regulation of cofactor metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. BP
GO:0051192 prosthetic group binding The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. MF
GO:0051193 regulation of cofactor metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. BP
GO:0051190 prosthetic group catabolic process The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. BP
GO:0051191 prosthetic group biosynthetic process The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. BP
GO:0051198 negative regulation of coenzyme metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. BP
GO:0051199 regulation of prosthetic group metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group. BP
GO:0021821 negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. BP
GO:0021820 organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial cell migration The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells. BP
GO:0021823 cerebral cortex tangential migration using cell-cell interactions The process whereby neurons interact with each other to promote migration along a tangential plane. BP
GO:0021822 negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex. BP
GO:0021825 substrate-dependent cerebral cortex tangential migration The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions. BP
GO:0021824 cerebral cortex tangential migration using cell-axon interactions The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons. BP
GO:0021827 postnatal olfactory bulb interneuron migration The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth. BP
GO:0021826 substrate-independent telencephalic tangential migration The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. BP
GO:0021829 oligodendrocyte cell migration from the subpallium to the cortex The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development. BP
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus The directional movement of gonadotrophin-releasing hormone producing neurons from the nasal placode to the hypothalamus. BP
GO:0051228 mitotic spindle disassembly The controlled breakdown of the spindle during a mitotic cell cycle. BP
GO:0051229 meiotic spindle disassembly The controlled breakdown of the spindle during a meiotic cell cycle. BP
GO:0051220 cytoplasmic sequestering of protein The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. BP
GO:0051221 tungsten incorporation into metallo-sulfur cluster The incorporation of tungsten into a metallo-sulfur cluster. BP
GO:0051222 positive regulation of protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells. BP
GO:0051223 regulation of protein transport Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells. BP
GO:0051224 negative regulation of protein transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells. BP
GO:0051225 spindle assembly The formation of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. BP
GO:0051226 meiotic spindle assembly The formation of the spindle during a meiotic cell cycle. BP
GO:0051227 mitotic spindle assembly The formation of the spindle during a mitotic cell cycle. BP
GO:0015558 p-aminobenzoyl-glutamate uptake permease activity NA MF
GO:0015559 multidrug efflux pump activity NA MF
GO:0015556 C4-dicarboxylate transporter activity Enables the directed movement of C4-dicarboxylate into, out of, within or between cells. MF
GO:0015557 arginine targeting transporter activity NA MF
GO:0015554 tartrate transporter activity Enables the directed movement of tartrate into, out of, within or between cells. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria. MF
GO:0015555 acriflavin resistant pump activity NA MF
GO:0015552 propionate transporter activity Enables the directed movement of propionate into, out of, within or between cells. Propionate (or propanoate) is the organic acid CH3-CH2-COOH. MF
GO:0007231 osmosensory signaling pathway The series of molecular signals initiated in response to osmotic change. BP
GO:0007232 osmosensory signaling pathway via Sho1 osmosensor A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system. BP
GO:0015551 3-hydroxyphenyl propanoate transporter activity Enables the directed movement of 3-hydroxyphenyl propanoate into, out of, within or between cells. MF
GO:0001682 tRNA 5'-leader removal Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. BP
GO:0001681 sialate O-acetylesterase activity Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. MF
GO:0001680 tRNA 3'-terminal CCA addition Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. BP
GO:0018139 peptide cross-linking via L-phenylalanine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018138 peptide cross-linking via L-serine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018137 peptide cross-linking via glycine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018136 peptidyl-thiazoline dehydrogenase activity NA MF
GO:0018135 peptidyl-cysteine cyclase activity NA MF
GO:0018134 peptide cross-linking via glycine oxazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018133 peptide cross-linking via L-cysteine oxazolinecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue. BP
GO:0018132 peptide cross-linking via L-cysteine oxazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. BP
GO:0018131 oxazole or thiazole biosynthetic process The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. BP
GO:0018130 heterocycle biosynthetic process The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). BP
GO:0019668 anaerobic catabolic process of pairs of amino acids The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP. BP
GO:0019669 anaerobic glycine catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP. BP
GO:0019664 glucose catabolic process to mixed acids The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP. BP
GO:0019665 anaerobic amino acid catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP. BP
GO:0019666 nitrogenous compound catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP. BP
GO:0019667 anaerobic L-alanine catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP. BP
GO:0019660 glycolytic fermentation Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. BP
GO:0019661 glucose catabolic process to lactate via pyruvate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via pyruvate, yielding energy in the form of adenosine triphosphate (ATP). BP
GO:0019662 non-glycolytic fermentation Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. BP
GO:0019663 homoacetate catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of homoacetate, yielding energy in the form of ATP. BP
GO:0001975 response to amphetamine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. BP
GO:0001974 blood vessel remodeling The reorganization or renovation of existing blood vessels. BP
GO:0001977 renal blood volume regulation of blood pressure A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. BP
GO:0001976 fast regulation of arterial pressure The process that modulates the force with which blood moves through the circulatory system that responds to a change within minutes or hours. BP
GO:0001971 negative regulation of activation of membrane attack complex Any process that stops, prevents or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. BP
GO:0001970 positive regulation of activation of membrane attack complex Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade. BP
GO:0001973 adenosine receptor signaling pathway The series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. BP
GO:0001972 retinoic acid binding Interacting selectively with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. MF
GO:0001979 chemoreceptor regulation of blood pressure The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. BP
GO:0001978 baroreceptor feedback regulation of blood pressure The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control. BP
GO:0021799 cerebral cortex radially oriented migration The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. BP
GO:0021798 forebrain dorsal-ventral pattern formation The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain. BP
GO:0021793 chemorepulsion of branchiomotor axon The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021792 chemoattraction of branchiomotor axon The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021791 chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021790 chemorepulsion of branchiomotor axon in branchial arch mesenchyme The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. BP
GO:0021797 forebrain anterior-posterior pattern formation The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain. BP
GO:0021796 cerebral cortex regionalization The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops. BP
GO:0021795 cerebral cortex cell migration The orderly movement of cells from one site to another in the cerebral cortex. BP
GO:0021794 thalamus development The process by which the thalamus changes over time, from its initial formation to its mature state. BP
GO:0043638 puromycin biosynthetic process The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. BP
GO:0043639 benzoate catabolic process The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. BP
GO:0017046 peptide hormone binding Interacting selectively with any peptide with hormonal activity in animals. MF
GO:0017047 adrenocorticotropin-releasing hormone binding Interacting selectively with adrenocorticotropin-releasing hormone. MF
GO:0017044 alpha-melanocyte stimulating hormone activity NA MF
GO:0017045 adrenocorticotropin-releasing hormone activity NA MF
GO:0017042 glycosylceramidase activity Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. MF
GO:0017040 ceramidase activity Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. MF
GO:0017041 galactosylgalactosylglucosylceramidase activity Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose. MF
GO:0005098 Ran GTPase activator activity Increases the rate of GTP hydrolysis by a GTPase of the Ran family. MF
GO:0017048 Rho GTPase binding Interacting selectively with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. MF
GO:0017049 GTP-Rho binding Interacting selectively with the GTP-bound form of the Rho protein. MF
GO:0005099 Ras GTPase activator activity Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily. MF
GO:0008601 protein phosphatase type 2A regulator activity Modulation of the activity of the enzyme protein phosphatase type 2A. MF
GO:0043633 modification-dependent RNA catabolic process Destruction of an RNA molecule, initiated by the covalent modification of the target RNA. BP
GO:0043635 methylnaphthalene catabolic process The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar. BP
GO:0005092 GDP-dissociation inhibitor activity NA MF
GO:0005093 Rab GDP-dissociation inhibitor activity NA MF
GO:0008607 phosphorylase kinase regulator activity Modulation of the activity of the enzyme phosphorylase kinase. MF
GO:0005090 Sar guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by the GTPase Sar. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0031729 CCR4 chemokine receptor binding Interacting selectively with a CCR4 chemokine receptor. MF
GO:0031728 CCR3 chemokine receptor binding Interacting selectively with a CCR3 chemokine receptor. MF
GO:0031723 CXCR4 chemokine receptor binding Interacting selectively with a CXCR4 chemokine receptor. MF
GO:0031722 hemoglobin beta binding Interacting selectively with a hemoglobin beta chain. MF
GO:0031721 hemoglobin alpha binding Interacting selectively with a hemoglobin alpha chain. MF
GO:0031720 haptoglobin binding Interacting selectively with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex. MF
GO:0031727 CCR2 chemokine receptor binding Interacting selectively with a CCR2 chemokine receptor. MF
GO:0031726 CCR1 chemokine receptor binding Interacting selectively with a CCR1 chemokine receptor. MF
GO:0031725 CXCR6 chemokine receptor binding Interacting selectively with a CXCR6 chemokine receptor. MF
GO:0031724 CXCR5 chemokine receptor binding Interacting selectively with a CXCR5 chemokine receptor. MF
GO:0048884 neuromast development The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals. BP
GO:0005095 GTPase inhibitor activity Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. MF
GO:0009350 ethanolamine ammonia-lyase complex An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. CC
GO:0009353 oxoglutarate dehydrogenase complex (sensu Eukaryota) A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0009355 DNA polymerase V complex NA CC
GO:0009357 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system. CC
GO:0009356 p-aminobenzoate synthetase complex NA CC
GO:0009359 Type II site-specific deoxyribonuclease complex A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. CC
GO:0009358 polyphosphate kinase complex Complex that possesses polyphosphate kinase activity. CC
GO:0004068 aspartate 1-decarboxylase activity Catalysis of the reaction: L-aspartate = beta-alanine + CO2. MF
GO:0042948 salicin transport The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of, within or between cells. BP
GO:0009689 induction of phytoalexin biosynthetic process The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection. BP
GO:0009688 abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. BP
GO:0009683 indoleacetic acid metabolic process The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants. BP
GO:0009682 induced systemic resistance A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling. BP
GO:0009687 abscisic acid metabolic process The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. BP
GO:0009686 gibberellic acid biosynthetic process The chemical reactions and pathways resulting in the formation of gibberellic acid. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. BP
GO:0009685 gibberellic acid metabolic process The chemical reactions and pathways involving gibberellic acid. Gibberellins are a class of highly modified terpenes that function as plant growth regulators. BP
GO:0009684 indoleacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants. BP
GO:0004060 arylamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. MF
GO:0042940 D-amino acid transport The directed movement of the dextrorotatory isomer of an amino acid into, out of, within or between cells. BP
GO:0004062 aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. MF
GO:0004063 aryldialkylphosphatase activity Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. MF
GO:0004064 arylesterase activity Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. MF
GO:0004065 arylsulfatase activity Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2-) (sulfate). MF
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. MF
GO:0004067 asparaginase activity Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. MF
GO:0008086 light-activated voltage-gated calcium channel activity NA MF
GO:0016808 proprotein convertase activity NA MF
GO:0008084 imaginal disc growth factor activity NA MF
GO:0008083 growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. MF
GO:0008080 N-acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. MF
GO:0008081 phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. MF
GO:0016801 hydrolase activity, acting on ether bonds Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. MF
GO:0016800 hydrolase activity, hydrolyzing S-glycosyl compounds NA MF
GO:0016803 ether hydrolase activity Catalysis of the hydrolysis of an ether bond, -O-. MF
GO:0016802 trialkylsulfonium hydrolase activity Catalysis of the hydrolysis of a thioether bond, -S-. MF
GO:0016805 dipeptidase activity Catalysis of the hydrolysis of a dipeptide. MF
GO:0016804 prolyl aminopeptidase activity Catalysis of the release of a N-terminal proline from a peptide. MF
GO:0016807 cysteine-type carboxypeptidase activity Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. MF
GO:0008089 anterograde axon cargo transport The directed movement of organelles along microtubules from the cell body toward the cell periphery in nerve cell axons. BP
GO:0008558 guanine-transporting ATPase activity Catalysis of the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in). MF
GO:0008559 xenobiotic-transporting ATPase activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). MF
GO:0008551 cadmium-exporting ATPase activity Catalysis of the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out). MF
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. MF
GO:0008554 sodium-exporting ATPase activity, phosphorylative mechanism Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism. MF
GO:0008555 chloride-transporting ATPase activity Catalysis of the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in). MF
GO:0008556 potassium-transporting ATPase activity Catalysis of the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). MF
GO:0047241 lipopolysaccharide N-acetylmannosaminouronosyltransferase activity Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP. MF
GO:0047240 lactosylceramide beta-1,3-galactosyltransferase activity Catalysis of the reaction: D-galactosyl-1,4-beta-D-glucosyl-R + UDP-galactose = D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R + UDP. MF
GO:0047243 flavanone 7-O-beta-glucosyltransferase activity Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP. MF
GO:0047242 hydroxyanthraquinone glucosyltransferase activity Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP. MF
GO:0047245 N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. MF
GO:0047244 N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. MF
GO:0047247 luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin 7-O-beta-D-glucuronide + UDP-D-glucuronate = luteolin 7-O-[beta-D-glucuronosyl-(1,2)-beta-D-glucuronide]-4'-O-beta-D-glucuronide + UDP. MF
GO:0047246 luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin 7-O-glucuronide + UDP-D-glucuronate = luteolin 7-O-beta-D-diglucuronide + UDP. MF
GO:0047249 sarsapogenin 3-beta-glucosyltransferase activity Catalysis of the reaction: (25S)-5-beta-spirostan-3-beta-ol + UDP-D-glucose = (25S)-5-beta-spirostan-3-beta-ol 3-O-beta-D-glucoside + UDP. MF
GO:0047248 nuatigenin 3-beta-glucosyltransferase activity Catalysis of the reaction: (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol + UDP-D-glucose = (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol 3-O-beta-D-glucoside + UDP. MF
GO:0032409 regulation of transporter activity Any process that modulates the activity of a transporter. BP
GO:0032408 MutSbeta complex binding Interacting selectively with the mismatch repair complex MutSbeta. MF
GO:0032403 protein complex binding Interacting selectively with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). MF
GO:0032402 melanosome transport The directed movement of melanosomes into, out of, within or between cells. BP
GO:0032401 establishment of melanosome localization The directed movement of a melanosome to a specific location. BP
GO:0032400 melanosome localization The processes by which a melanosome is transported to, and/or maintained in, a specific location within the cell. BP
GO:0032407 MutSalpha complex binding Interacting selectively with the mismatch repair complex MutSalpha. MF
GO:0032406 MutLbeta complex binding Interacting selectively with the mismatch repair complex MutLbeta. MF
GO:0032405 MutLalpha complex binding Interacting selectively with the mismatch repair complex MutLalpha. MF
GO:0032404 mismatch repair complex binding Interacting selectively with a mismatch repair complex. MF
GO:0030809 negative regulation of nucleotide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. BP
GO:0030808 regulation of nucleotide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides. BP
GO:0030805 regulation of cyclic nucleotide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. BP
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides. BP
GO:0030807 positive regulation of cyclic nucleotide catabolic process Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. BP
GO:0030806 negative regulation of cyclic nucleotide catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. BP
GO:0030801 positive regulation of cyclic nucleotide metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. BP
GO:0030800 negative regulation of cyclic nucleotide metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. BP
GO:0030803 negative regulation of cyclic nucleotide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides. BP
GO:0030802 regulation of cyclic nucleotide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides. BP
GO:0050869 negative regulation of B cell activation Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation. BP
GO:0050868 negative regulation of T cell activation Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation. BP
GO:0050865 regulation of cell activation Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. BP
GO:0050864 regulation of B cell activation Any process that modulates the frequency, rate or extent of B cell activation. BP
GO:0050867 positive regulation of cell activation Any process that activates or increases the frequency, rate or extent of activation. BP
GO:0050866 negative regulation of cell activation Any process that stops, prevents or reduces the frequency, rate or extent of cell activation. BP
GO:0050861 positive regulation of B cell receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. BP
GO:0050860 negative regulation of T cell receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. BP
GO:0050863 regulation of T cell activation Any process that modulates the frequency, rate or extent of T cell activation. BP
GO:0050862 positive regulation of T cell receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. BP
GO:0046596 regulation of virion penetration into host Any process that modulates the frequency, rate or extent of the introduction of virus particles into the cell. BP
GO:0046597 negative regulation of virion penetration into host Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of virus particles into the cell. BP
GO:0046594 maintenance of pole plasm mRNA localization The process of maintaining mRNA in a specific location in the oocyte pole plasm. BP
GO:0046595 establishment of pole plasm mRNA localization The processes by which mRNA is recruited to the oocyte pole plasm. BP
GO:0046592 polyamine oxidase activity Catalysis of the reaction: N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2. MF
GO:0046593 mandelonitrile lyase activity Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde. MF
GO:0046590 embryonic leg morphogenesis The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands. BP
GO:0046591 embryonic leg joint morphogenesis The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. Morphogenesis pertains to the creation of form. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. BP
GO:0046598 positive regulation of virion penetration into host Any process that activates or increases the frequency, rate or extent of the introduction of virus particles into the cell. BP
GO:0046599 regulation of centriole replication Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. BP
GO:0046628 positive regulation of insulin receptor signaling pathway Any process that increases the frequency, rate or extent of insulin receptor signaling. BP
GO:0046629 gamma-delta T cell activation The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. BP
GO:0046620 regulation of organ size Any process that modulates the frequency, rate or extent of growth of an organ of an organism. BP
GO:0046621 negative regulation of organ size Any process that stops, prevents or reduces the frequency, rate or extent of growth of an organ of an organism. BP
GO:0046622 positive regulation of organ size Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. BP
GO:0046623 sphingolipid-translocating ATPase activity Catalysis of the movement of sphingolipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP. MF
GO:0046624 sphingolipid transporter activity Enables the directed movement of sphingolipids into, out of, within or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). MF
GO:0046625 sphingolipid binding Interacting selectively with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). MF
GO:0046626 regulation of insulin receptor signaling pathway Any process that modulates the frequency, rate or extent of insulin receptor signaling. BP
GO:0046627 negative regulation of insulin receptor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling. BP
GO:0035299 inositol pentakisphosphate 2-kinase activity Catalysis of the reaction: inositol (1,3,4,5,6)-pentakisphosphate + ATP = inositol (1,2,3,4,5,6)-hexakisphosphate + ADP. MF
GO:0035298 regulation of Malpighian tubule size Ensuring that a Malpighian tubule is the correct length and diameter. BP
GO:0035297 regulation of Malpighian tubule diameter Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells. BP
GO:0035296 regulation of tube diameter Ensuring that a tube is the correct width. BP
GO:0035295 tube development The process whose specific outcome is the progression of a tube over time, from its intial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. BP
GO:0035294 determination of wing disc primordium Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc. BP
GO:0035293 larval cuticle pattern formation (sensu Insecta) The process that gives rise to the patterns of cell differentiation in the larval cuticle. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0035292 specification of segmental identity, trunk The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0035291 specification of segmental identity, intercalary segment The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. BP
GO:0035290 trunk segmentation Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. BP
GO:0030113 capsule (sensu Bacteria) A protective structure surrounding some cells attached externally to the cell wall, often, but not always, constructed of polysaccharides. Capsules play an important role in pathogenicity, preventing phagocytosis by eukaryotic cells. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0030112 glycocalyx The outermost external structures which surround a bacterial cell. CC
GO:0030111 regulation of Wnt receptor signaling pathway Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway. BP
GO:0030110 HLA-C specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte. MF
GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. CC
GO:0030116 glial cell line-derived neurotrophic factor receptor binding A growth factor that binds to glial cell line-derived neurotrophic factor receptors. MF
GO:0030115 S-layer A crystalline protein layer surrounding some bacteria. CC
GO:0030114 slime layer A protective structure surrounding some bacteria, usually composed of polysaccharides. CC
GO:0030119 membrane coat adaptor complex Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. CC
GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. CC
GO:0047613 aconitate decarboxylase activity Catalysis of the reaction: cis-aconitate = itaconate + CO2. MF
GO:0004419 hydroxymethylglutaryl-CoA lyase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate. MF
GO:0004418 hydroxymethylbilane synthase activity Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. MF
GO:0004415 hyalurononglucosaminidase activity Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. MF
GO:0004414 homoserine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine. MF
GO:0004417 hydroxyethylthiazole kinase activity Catalysis of the reaction: ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole = ADP + 4-methyl-5-(2-phosphoethyl)-thiazole. MF
GO:0004416 hydroxyacylglutathione hydrolase activity Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. MF
GO:0004411 homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. MF
GO:0004410 homocitrate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + 2-oxoglutarate = 2-hydroxybutane-1,2,4-tricarboxylate + CoA. MF
GO:0004413 homoserine kinase activity Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. MF
GO:0004412 homoserine dehydrogenase activity Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. MF
GO:0006927 transformed cell apoptosis The process of apoptosis in transformed cells, cells that have undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm. BP
GO:0006926 virus-infected cell apoptosis The process of apoptosis in cells infected with a virus. BP
GO:0006925 inflammatory cell apoptosis The process of apoptosis in inflammatory cells, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. BP
GO:0048081 positive regulation of cuticle pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. BP
GO:0006923 cleavage of cytoskeletal proteins during apoptosis The proteolytic degradation of cytoskeletal proteins during apoptosis, leading to the collapse of cytoskeletal structures. BP
GO:0006922 cleavage of lamin The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina. BP
GO:0048084 positive regulation of adult cuticle pigmentation Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. BP
GO:0008944 oligopeptidase A activity Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5. MF
GO:0048088 regulation of male pigmentation Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males. BP
GO:0008948 oxaloacetate decarboxylase activity Catalysis of the reaction: oxaloacetate = pyruvate + CO2. MF
GO:0006929 substrate-bound cell migration The orderly movement of cells from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. BP
GO:0006928 cell motility Any process involved in the controlled movement of a cell. BP
GO:0042624 ATPase activity, uncoupled Catalysis of the reaction: ATP + H2O = ADP + phosphate; not directly coupled to any other reaction. MF
GO:0042625 ATPase activity, coupled to transmembrane movement of ions Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. MF
GO:0042626 ATPase activity, coupled to transmembrane movement of substances Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance across a membrane. MF
GO:0042627 chylomicron A particle composed of a central core of triglycerides surrounded by a protein-phospholipid coating. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. CC
GO:0042620 poly(3-hydroxyalkanoate) metabolic process The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. BP
GO:0042621 poly(3-hydroxyalkanoate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. BP
GO:0042622 photoreceptor outer segment membrane The membrane surrounding the outer segment of a vertebrate photoreceptor. CC
GO:0042623 ATPase activity, coupled Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane. MF
GO:0042628 mating plug formation The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males. BP
GO:0042629 mast cell granule Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. CC
GO:0018739 4-hydroxybenzoyl-CoA thioesterase activity Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA. MF
GO:0018738 S-formylglutathione hydrolase activity Catalysis of the reaction: S-formylglutathione + H2O = glutathione + formate. MF
GO:0018734 butyrolactone hydrolase activity Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate. MF
GO:0018737 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA. MF
GO:0018736 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA. MF
GO:0018731 1-oxa-2-oxocycloheptane lactonase activity Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate. MF
GO:0018730 glutaconate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA. MF
GO:0018733 3,4-dihydrocoumarin hydrolase activity Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate. MF
GO:0018732 sulfolactone hydrolase activity Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate. MF
GO:0019062 virion attachment to host cell surface receptor The processes involved in the specific binding of a viral antireceptor to a cell surface receptor. BP
GO:0019063 virion penetration into host cell The processes required for the introduction of virus particles into the cell. BP
GO:0019060 intracellular transport of viral proteins in host cell The directed movement of viral proteins within the host cell. BP
GO:0019061 uncoating of virus A general term applied to the events that occur after penetration; refers to the 'uncoating' of the viral genome from the nucleocapsid core. BP
GO:0019066 translocation of virus into host cell The translocation of an entire virus particle across the host cell plasma membrane. BP
GO:0019067 viral assembly, maturation, egress, and release The processes involved in the assembly, maturation, egress, and release of progeny virions. BP
GO:0019064 viral envelope fusion with host membrane A form of viral penetration which involves the fusion of the virion envelope with the cellular membrane. BP
GO:0019065 receptor mediated endocytosis of virus by host Endocytosis of the virus particle resulting in the accumulation of virus particles within the cell via cytoplasmic vesicles. BP
GO:0019068 virus assembly A late phase of viral replication during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. BP
GO:0019069 viral capsid assembly The assembly of a virus capsid from its protein subunits. BP
GO:0007339 binding of sperm to zona pellucida The process by which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. BP
GO:0007338 fertilization (sensu Metazoa) The union of male and female gametes to form a zygote. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0052360 catabolism by host of symbiont macromolecule The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052361 catabolism by organism of macromolecule in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052362 catabolism by host of symbiont protein The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052363 catabolism by organism of protein in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052364 catabolism by host of substance in symbiont The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052365 catabolism by host of symbiont xylan The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052366 catabolism by organism of xylan in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052367 disassembly by host of symbiont cellular component The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0052368 disassembly by organism of cellular component in other organism during symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052369 positive regulation by symbiont of defense-related host reactive oxygen species production Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0005823 central plaque of spindle pole body One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope. CC
GO:0005822 inner plaque of spindle pole body One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus. CC
GO:0051460 negative regulation of adrenocorticotropin hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of adrenocorticotropin hormone from a cell or group of cells. BP
GO:0051461 positive regulation of adrenocorticotropin hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of adrenocorticotropin hormone from a cell or group of cells. BP
GO:0005827 polar microtubule Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. CC
GO:0051467 detection of steroid hormone stimulus The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal. BP
GO:0009647 skotomorphogenesis The control of plant growth, development, and differentiation in response to growth in darkness. BP
GO:0005825 half bridge of spindle pole body Structure adjacent to the plaques of the spindle pole body. CC
GO:0005824 outer plaque of spindle pole body One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm. CC
GO:0005829 cytosol That part of the cytoplasm that does not contain membranous or particulate subcellular components. CC
GO:0009646 response to absence of light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. BP
GO:0005828 kinetochore microtubule Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. CC
GO:0009645 response to low light intensity A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. BP
GO:0001315 age-dependent response to reactive oxygen species A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. BP
GO:0001314 replication of extrachromosomal circular DNA during replicative cell aging Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication. BP
GO:0001317 accumulation of oxidatively modified proteins during replicative cell aging Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking. BP
GO:0001316 age-dependent response to reactive oxygen species during replicative cell aging A change in state or activity of a cell or an organism occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. BP
GO:0001311 formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age. BP
GO:0001310 extrachromosomal rDNA circle accumulation during replicative cell aging Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. BP
GO:0001313 formation of extrachromosomal circular DNA during replicative cell aging Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age. BP
GO:0001312 replication of extrachromosomal rDNA circles during replicative cell aging Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication. BP
GO:0001319 inheritance of oxidatively modified proteins during replicative cell aging Process by which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells. BP
GO:0001318 formation of oxidatively modified proteins during replicative cell aging Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking. BP
GO:0005403 hydrogen:sugar symporter activity Catalysis of the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). MF
GO:0005402 cation:sugar symporter activity Catalysis of the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). MF
GO:0007256 activation of JNKK activity The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress. BP
GO:0015571 N-acetylgalactosamine transporter activity Enables the directed movement of N-acetylgalactosamine into, out of, within or between cells. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. MF
GO:0015572 N-acetylglucosamine transporter activity Enables the directed movement of N-acetylglucosamine into, out of, within or between cells. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein. MF
GO:0015574 trehalose transporter activity Enables the directed movement of trehalose into, out of, within or between cells. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens. MF
GO:0007253 cytoplasmic sequestering of NF-kappaB The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. BP
GO:0007250 activation of NF-kappaB-inducing kinase The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. BP
GO:0009642 response to light intensity A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. BP
GO:0000048 peptidyltransferase activity Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). MF
GO:0000049 tRNA binding Interacting selectively with transfer RNA. MF
GO:0000042 protein targeting to Golgi The process of directing proteins towards the Golgi using signals contained within the protein. BP
GO:0000040 low affinity iron ion transport NA BP
GO:0000041 transition metal ion transport The directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. BP
GO:0000046 autophagic vacuole fusion The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bound structures (autophagic bodies) appear in the vacuole. BP
GO:0000044 ascorbate stabilization The reduction of the ascorbate free radical to a stable form. BP
GO:0000045 autophagic vacuole formation The formation of a double membrane-bound structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. BP
GO:0009640 photomorphogenesis The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis. BP
GO:0004759 serine esterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. MF
GO:0004753 saccharopine dehydrogenase activity NA MF
GO:0004750 ribulose-phosphate 3-epimerase activity Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. MF
GO:0004751 ribose-5-phosphate isomerase activity Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. MF
GO:0004756 selenide, water dikinase activity Catalysis of the reaction: ATP + selenide + H2O = AMP + selenophosphate + phosphate. MF
GO:0004757 sepiapterin reductase activity Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+. MF
GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Catalysis of the reaction: saccharopine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+. MF
GO:0004755 saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+. MF
GO:0015295 solute:hydrogen symporter activity Catalysis of the reaction: solute(out) + H+(out) = solute(in) + H+(in). MF
GO:0015294 solute:cation symporter activity Catalysis of the reaction: solute(out) + cation(out) = solute(in) + cation(in). MF
GO:0015297 antiporter activity Catalysis of the exchange of one or more molecular species for another across a membrane. MF
GO:0018079 protein amino acid halogenation The addition of a halogen to a protein amino acid. BP
GO:0015291 porter activity A transporter of solutes that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane. MF
GO:0015290 electrochemical potential-driven transporter activity Catalysis of the carrier-mediated transfer of one or more substances across a membrane. Transport occurs in three ways: uniport, a single species is transported by facilitated diffusion in a process not coupled to the utilization of a primary source of energy; antiport, two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy; and symport, two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. MF
GO:0015293 symporter activity Catalyze the transport of two or more molecular species across a membrane, transport being in the same direction. MF
GO:0015292 uniporter activity Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. MF
GO:0018072 peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid The posttranslational modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit. BP
GO:0018073 protein amino acid bromination NA BP
GO:0018070 peptidyl-serine phosphopantetheinylation The posttranslational phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine. BP
GO:0018071 NAD(P)-cysteine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine. MF
GO:0015299 solute:hydrogen antiporter activity Catalysis of the reaction: solute(out) + H+(in) = solute(in) + H+(out). MF
GO:0018077 protein amino acid iodination The posttranslational iodination of protein amino-acids. BP
GO:0018074 peptidyl-histidine bromination The posttranslational bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown. BP
GO:0018075 peptidyl-phenylalanine bromination The posttranslational bromination of phenylalanine. BP
GO:0016929 SUMO-specific protease activity Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates. MF
GO:0016926 protein desumoylation The process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. BP
GO:0016925 protein sumoylation The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. BP
GO:0016922 ligand-dependent nuclear receptor binding Interacting selectively, in a ligand dependent manner, with a nuclear receptor protein. MF
GO:0016920 pyroglutamyl-peptidase activity NA MF
GO:0016921 pyroglutamyl-peptidase II activity Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides. MF
GO:0021616 glossopharyngeal nerve formation The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. BP
GO:0021617 glossopharyngeal nerve structural organization The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. BP
GO:0021614 glossopharyngeal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. BP
GO:0021615 glossopharyngeal nerve morphogenesis The process by which the anatomical structure of the glossopharyngeal nerve is generated and organized. Morphogenesis pertains to the creation of form. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. BP
GO:0021612 facial nerve structural organization The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. BP
GO:0021613 facial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. BP
GO:0021610 facial nerve morphogenesis The process by which the anatomical structure of the facial nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. BP
GO:0021611 facial nerve formation The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. BP
GO:0021618 hypoglossal nerve morphogenesis The process by which the anatomical structure of the hypoglossal nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. BP
GO:0021619 hypoglossal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. BP
GO:0015749 monosaccharide transport The directed movement of monosaccharides into, out of, within or between cells. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. BP
GO:0015748 organophosphate ester transport The directed movement of organophosphate esters into, out of, within or between cells. Organophosphate esters are small organic molecules containing phosphate ester bonds. BP
GO:0015747 urate transport The directed movement of urate into, out of, within or between cells. BP
GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells. BP
GO:0015745 tartrate transport The directed movement of tartrate into, out of, within or between cells. BP
GO:0015744 succinate transport The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of, within or between cells. BP
GO:0015743 malate transport The directed movement of malate into, out of, within or between cells. BP
GO:0015742 alpha-ketoglutarate transport The directed movement of alpha-ketoglutarate into, out of, within or between cells. BP
GO:0015741 fumarate transport The directed movement of fumarate into, out of, within or between cells. BP
GO:0015740 C4-dicarboxylate transport The directed movement of C4-dicarboxylate into, out of, within or between cells. BP
GO:0016218 polyketide synthase activity NA MF
GO:0016219 GDP-dissociation stimulator activity NA MF
GO:0046028 electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II. MF
GO:0046029 mannitol dehydrogenase activity Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + NADH + H+. MF
GO:0046026 precorrin-4 C11-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5. MF
GO:0046027 phospholipid:diacylglycerol acyltransferase activity Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol. MF
GO:0046024 positive regulation of transcription from RNA polymerase III promoter, mitotic Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis. BP
GO:0016217 N-ethylammeline chlorohydrolase activity NA MF
GO:0016210 naringenin-chalcone synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2. MF
GO:0046023 regulation of transcription from RNA polymerase III promoter, mitotic A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis. BP
GO:0016212 kynurenine-oxoglutarate transaminase activity Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. MF
GO:0016213 linoleoyl-CoA desaturase activity Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O. MF
GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate. MF
GO:0030350 iron-responsive element binding Interacting selectively with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins. MF
GO:0030353 fibroblast growth factor receptor antagonist activity Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist. MF
GO:0030352 inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. MF
GO:0030354 melanin-concentrating hormone activity NA MF
GO:0030357 protein phosphatase type 2B activity Catalysis of the reaction: a phosphoprotein + n H2O = a protein + n phosphate. MF
GO:0030359 protein phosphatase type 2B regulator activity Modulation of the activity of the enzyme protein phosphatase type 2B. MF
GO:0030689 Noc complex Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis. CC
GO:0030688 nucleolar preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. CC
GO:0030683 evasion by virus of host immune response Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0030682 evasion or tolerance of host defense response Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0030681 multimeric ribonuclease P complex A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. CC
GO:0030680 dimeric ribonuclease P complex A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. CC
GO:0030687 nucleolar preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. CC
GO:0030686 90S preribosome A preribosomal complex consisting of the 35S pre-rRNA, the 5S rRNA, early-associating ribosomal proteins, and associated proteins. CC
GO:0030685 nucleolar preribosome Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis. CC
GO:0030684 preribosome Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. CC
GO:0047854 diguanidinobutanase activity Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea. MF
GO:0047855 dihydrobunolol dehydrogenase activity Catalysis of the reaction: (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH. MF
GO:0031084 BLOC-2 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru. CC
GO:0047857 dihydrouracil oxidase activity Catalysis of the reaction: 5,6-dihydrouracil + O2 = uracil + H2O2. MF
GO:0047850 diaminopimelate dehydrogenase activity Catalysis of the reaction: meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH. MF
GO:0031083 BLOC-1 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complx contains the Pallidin, Muted, Cappuccino, Dysbindin, Sapin, BLOS1, BLOS2, AND BLOS3 proteins. CC
GO:0047852 diferric-transferrin reductase activity Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH. MF
GO:0031081 nuclear pore distribution The processes that establish the spatial arrangement of nuclear pores within the nuclear envelope. BP
GO:0047858 dihydroxyfumarate decarboxylase activity Catalysis of the reaction: dihydroxyfumarate = tartronate semialdehyde + CO2. MF
GO:0030061 mitochondrial crista Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. CC
GO:0031088 platelet dense granule membrane The lipid bilayer surrounding the platelet dense granule. CC
GO:0031089 platelet dense granule lumen The volume enclosed by the membrane of the platelet dense granule. CC
GO:0035012 polytene chromosome, telomeric region The terminal region of a polytene chromosome. CC
GO:0035017 cuticle pattern formation The regionalization process that gives rise to the patterns of cell differentiation in the cuticle. BP
GO:0031558 induction of apoptosis in response to chemical stimulus Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus. BP
GO:0031559 oxidosqualene cyclase activity Catalysis of the cyclization of (S)-2,3-epoxysqualene to triterpene. MF
GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. BP
GO:0031551 regulation of brain-derived neurotrophic factor receptor activity Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor receptor activity. BP
GO:0031552 negative regulation of brain-derived neurotrophic factor receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of brain-derived neurotrophic factor receptor activity. BP
GO:0031553 positive regulation of brain-derived neurotrophic factor receptor activity Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor receptor activity. BP
GO:0031554 regulation of transcription termination Any process that modulates the frequency, rate, extent, or location of transcription termination. BP
GO:0031555 transcriptional attenuation Regulation of transcription through variation in where transcription termination occurs. BP
GO:0031556 ribosome-mediated transcriptional attenuation A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as availabe amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch. BP
GO:0031557 induction of programmed cell death in response to chemical stimulus A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus. BP
GO:0009526 plastid envelope The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space. CC
GO:0009527 plastid outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope. CC
GO:0009524 phragmoplast Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules. CC
GO:0009525 phragmosome A flattened membranous vesicle containing cell wall components. CC
GO:0009522 photosystem I Photosystem that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. CC
GO:0009523 photosystem II An integral membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. CC
GO:0009521 photosystem One of the photochemical systems containing photosynthetic and accessory pigments and electron carriers that operate in sequence to perform the two light reactions of photosynthesis. CC
GO:0009528 plastid inner membrane The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. CC
GO:0009529 plastid intermembrane space The region between the inner and outer lipid bilayers of the plastid envelope. CC
GO:0046819 protein secretion by the type V secretion system The process by which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway. BP
GO:0046818 dense nuclear body A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously. CC
GO:0046817 chemokine receptor antagonist activity Interacts with chemokine receptors to reduce the action of a chemokine. MF
GO:0046816 virion transport vesicle A vesicle used to transport the partial or complete virion between cellular compartments. CC
GO:0046815 genome retention in viral capsid The processes by which the viral genome is retained within the capsid during genome cleavage and packaging. BP
GO:0046814 virion attachment, binding of host cell surface coreceptor The process during virion attachment where a virion binds to a host cell surface receptor after an initial binding event has occurred, resulting in the fusion of the virion and host cell membranes and the initiation of viral entry. BP
GO:0046813 virion attachment, binding of host cell surface receptor The process during virion attachment where a virion binds to a host cell receptor, resulting in a conformational change of the virus protein. BP
GO:0046812 host cell surface binding Interacting selectively with the surface of a host cell. MF
GO:0046811 histone deacetylase inhibitor activity Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. MF
GO:0046810 host cell extracellular matrix binding Interacting selectively with the extracellular matrix of a host cell. MF
GO:0045548 phenylalanine ammonia-lyase activity Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3. MF
GO:0045549 9-cis-epoxycarotenoid dioxygenase activity Catalysis of the oxidative cleavage of 9-cis-epoxy-carotenoids (e.g. neoxanthin and violaxanthin) to xanthoxin and C-25 apocarotenoids. MF
GO:0045544 gibberellin 20-oxidase activity Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones. MF
GO:0045545 syndecan binding Interacting selectively with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. MF
GO:0045547 dehydrodolichyl diphosphate synthase activity Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate. MF
GO:0045540 regulation of cholesterol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. BP
GO:0045541 negative regulation of cholesterol biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. BP
GO:0045542 positive regulation of cholesterol biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. BP
GO:0045543 gibberellin 2-beta-dioxygenase activity Catalysis of the reaction: gibberellin 1 + 2-oxoglutarate + O2 = 2-beta-hydroxygibberellin 1 + succinate + CO2. MF
GO:0047036 codeinone reductase (NADPH) activity Catalysis of the reaction: NADP+ + codeine = NADPH + H+ + codeinone. MF
GO:0047037 salutaridine reductase (NADPH) activity Catalysis of the reaction: NADP+ + salutaridinol = NADPH + H+ + salutaridine. MF
GO:0047034 15-hydroxyicosatetraenoate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate. MF
GO:0042007 interleukin-18 binding Interacting selectively with interleukin-18. MF
GO:0047032 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity Catalysis of the reaction: NADP+ + 3-alpha-hydroxyglycyrrhetinate = NADPH + H+ + 3-oxoglycyrrhetinate. MF
GO:0047033 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-6,9-alpha-epoxy-11-alpha-hydroxy-15-oxoprosta-5,13-dienoate. MF
GO:0042002 hermaphrodite somatic sex determination (sensu Nematoda) The determination of sex and sexual phenotypes in a hermaphroditic nematode's soma, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0047031 diethyl 2-methyl-3-oxosuccinate reductase activity Catalysis of the reaction: NADP+ + diethyl (2R,3R)-2-methyl-3-hydroxysuccinate = NADPH + H+ + diethyl-2-methyl-3-oxosuccinate. MF
GO:0042008 interleukin-18 receptor activity Combining with interleukin-18 to initiate a change in cell activity. MF
GO:0042009 interleukin-15 binding Interacting selectively with interleukin-15. MF
GO:0047038 D-arabinitol 2-dehydrogenase activity Catalysis of the reaction: NAD+ + D-arabitol = NADH + H+ + D-ribulose. MF
GO:0047039 tetrahydroxynaphthalene reductase activity Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol. MF
GO:0031943 regulation of glucocorticoid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. BP
GO:0031942 i-AAA complex Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases. CC
GO:0031941 filamentous actin A two-stranded helical polymer of the protein actin. CC
GO:0031940 positive regulation of chromatin silencing at telomere Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres. BP
GO:0031947 negative regulation of glucocorticoid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. BP
GO:0031946 regulation of glucocorticoid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. BP
GO:0031945 positive regulation of glucocorticoid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. BP
GO:0031944 negative regulation of glucocorticoid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. BP
GO:0031949 regulation of glucocorticoid catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. BP
GO:0031948 positive regulation of glucocorticoid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. BP
GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. CC
GO:0005642 annulate lamellae Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER. CC
GO:0005641 nuclear envelope lumen The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. CC
GO:0005640 nuclear outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. CC
GO:0002695 negative regulation of leukocyte activation Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. BP
GO:0002694 regulation of leukocyte activation Any process that modulates the frequency, rate, or extent of leukocyte activation. BP
GO:0002697 regulation of immune effector process Any process that modulates the frequency, rate, or extent of an immune effector process. BP
GO:0002696 positive regulation of leukocyte activation Any process that activates or increases the frequency, rate, or extent of leukocyte activation. BP
GO:0002691 regulation of cellular extravasation Any process that modulates the frequency, rate, or extent of cellular extravasation. BP
GO:0002690 positive regulation of leukocyte chemotaxis Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. BP
GO:0002693 positive regulation of cellular extravasation Any process that activates or increases the frequency, rate, or extent of cellular extravasation. BP
GO:0002692 negative regulation of cellular extravasation Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation. BP
GO:0042026 protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. BP
GO:0002699 positive regulation of immune effector process Any process that activates or increases the frequency, rate, or extent of an immune effector process. BP
GO:0002698 negative regulation of immune effector process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. BP
GO:0042028 juglone-sensitive peptidyl-prolyl cis-trans isomerase activity NA MF
GO:0042029 fibrolase activity Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen. MF
GO:0048789 cytoskeletal matrix organization at active zone The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane. BP
GO:0048788 presynaptic cytoskeletal matrix assembled at active zones The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites. CC
GO:0002349 histamine production during acute inflammatory response The synthesis or release of histamine following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels. BP
GO:0002348 central B cell positive selection Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors. BP
GO:0048785 hatching gland development The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process. BP
GO:0002346 B cell positive selection Any process by which B cells are selected to survive based on signaling through the B cell antigen receptor. BP
GO:0048787 active zone presynaptic plasma membrane The active zone is a specialized site of the presynaptic plasma membrane where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. CC
GO:0048786 presynaptic active zone A specialized presynaptic plasma membrane region where synaptic vesicles dock and fuse. CC
GO:0002343 peripheral B cell selection Processes of B cell selection that occur in the periphery. BP
GO:0002342 central B cell deletion The deletion of B cells by apoptosis occurring as part of central tolerance induction and B cell selection. BP
GO:0002341 central B cell anergy Processes of anergy that occur in the bone marrow. BP
GO:0048782 negative regulation of cyanophore differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cyanophore differentiation. BP
GO:0007487 analia development (sensu Endopterygota) The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia develops from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007486 female genitalia development (sensu Endopterygota) The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007485 male genitalia development (sensu Endopterygota) The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007484 genitalia development (sensu Endopterygota) The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007483 genital disc morphogenesis The process by which the anatomical structures derived from the genital disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut. BP
GO:0007482 haltere development The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings. BP
GO:0007481 haltere disc morphogenesis The process by which the anatomical structures derived from the haltere disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. BP
GO:0007480 leg morphogenesis (sensu Endopterygota) The process by which the anatomical structures of leg are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0007489 maintenance of imaginal histoblast diploidy The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells. BP
GO:0007488 histoblast morphogenesis The process by which the anatomical structures derived from the histoblast disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen. BP
GO:0004598 peptidylamidoglycolate lyase activity Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. MF
GO:0004590 orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. MF
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. MF
GO:0004592 pantoate-beta-alanine ligase activity Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. MF
GO:0004593 pantothenase activity Catalysis of the reaction: pantothenate + H2O = pantoate + beta-alanine. MF
GO:0004594 pantothenate kinase activity Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. MF
GO:0004595 pantetheine-phosphate adenylyltransferase activity Catalysis of the reaction: ATP + pantetheine 4'-phosphate = diphosphate + dephospho-CoA. MF
GO:0004596 peptide alpha-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. MF
GO:0004597 peptide-aspartate beta-dioxygenase activity Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2. MF
GO:0048129 oocyte microtubule cytoskeleton polarization (sensu Insecta) Establishment and maintenance of an axis of polarity of the oocyte microtubule network such that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048128 oocyte nucleus migration during oocyte axis determination (sensu Insecta) The directed movement of the oocyte nucleus from the extreme posterior of the cell to an asymmetric position in the anterior of the cell during the establishment and maintenance of the axes of the oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048123 oocyte dorsal/ventral axis determination (sensu Insecta) The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). In Drosophila, formation of the oocyte dorsoventral axis occurs later in oogenesis, once the anteroposterior axis is established. BP
GO:0048125 maternal determination of dorsal/ventral axis, oocyte, soma encoded (sensu Insecta) Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048124 maternal determination of dorsal/ventral axis, oocyte, germ-line encoded (sensu Insecta) Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048127 maintenance of oocyte nucleus localization during oocyte axis determination (sensu Insecta) Maintenance of the oocyte nucleus in its anterior-dorsal position in the egg chamber during the establishment and maintenance of the axes of the oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0048126 establishment of oocyte nucleus localization during oocyte axis determination (sensu Insecta) The re-positioning of the oocyte nucleus to a dorsal-anterior position in the egg chamber, an essential step in the establishment and maintenance of the dorsal/ventral axis of the oocyte. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0042783 active evasion of host immune response Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042782 passive evasion of host immune response Any mechanism of immune avoidance that does not directly interfere with the host immune system; for example, some viruses enter a state of latency where their protein production is drastically downregulated, meaning that they are not detected by the host immune system. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042781 3'-tRNA processing endoribonuclease activity Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. MF
GO:0042780 tRNA 3'-processing The process by which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA. BP
GO:0042787 protein ubiquitination during ubiquitin-dependent protein catabolic process The process by which a ubiquitin moiety, or multiple moieties, are covalently attached to the target protein, thereby initiating the degradation of that protein. BP
GO:0042786 active evasion of host immune response via regulation of host antigen processing and presentation Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042785 active evasion of host immune response via regulation of host cytokine network Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042784 active evasion of host immune response via regulation of host complement system Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0042789 mRNA transcription from RNA polymerase II promoter The synthesis of messenger RNA (mRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II-specific promoter. BP
GO:0042788 polysomal ribosome A ribosome bound to mRNA that forms part of a polysome. CC
GO:0018502 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone. MF
GO:0018503 trans-1,2-dihydrodiolphenanthrene dehydrogenase activity Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene. MF
GO:0052542 callose deposition during defense response The processes by which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. BP
GO:0052543 callose deposition in cell wall The processes by which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. BP
GO:0052544 callose deposition in cell wall during defense response The processes by which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. BP
GO:0052545 callose localization The processes by which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. BP
GO:0052546 cell wall pectin metabolism The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. BP
GO:0018505 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+. MF
GO:0052548 regulation of protease activity Any process that modulates the frequency, rate or extent of nuclease activity, the endohydrolysis of peptide linkages within proteins. BP
GO:0052549 response to phytoalexin production by other organism during symbiotic interaction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle. BP
GO:0018509 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+. MF
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. MF
GO:0003904 deoxyribodipyrimidine photo-lyase activity Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). The enzyme catalyzes the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme. MF
GO:0003905 alkylbase DNA N-glycosylase activity Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines. MF
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. MF
GO:0003909 DNA ligase activity Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another; requires an energy source such as ATP or NAD+. MF
GO:0019457 methionine catabolic process to succinyl-CoA The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA. BP
GO:0019456 L-cysteine catabolic process via cystine, using cysteine transaminase The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3). BP
GO:0019455 L-cysteine catabolic process via cystine, using cystine reductase The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6). BP
GO:0019454 L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4). BP
GO:0019453 L-cysteine catabolic process via cystine The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine. BP
GO:0019452 L-cysteine catabolic process to taurine The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine. BP
GO:0019451 L-cysteine catabolic process to pyruvate, using cysteine dioxygenase The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20). BP
GO:0019450 L-cysteine catabolic process to pyruvate The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate. BP
GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. BP
GO:0019459 glutamate deamidation NA BP
GO:0019458 methionine catabolic process via 2-oxobutanoate The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate. BP
GO:0042875 D-galactonate transport The directed movement of D-galactonate, the dextrorotatory isomer of galactonate, into, out of, within or between cells. BP
GO:0042874 D-glucuronate transport The directed movement of D-glucuronate, the dextrorotatory isomer of glucuronate into, out of, within or between cells. BP
GO:0042877 D-galactarate transporter activity Enables the directed movement of D-galactarate, the dextrorotatory isomer of the anion of galactaric acid, into, out of, within or between cells. MF
GO:0042876 aldarate transporter activity Enables the directed movement of aldarate into, out of, within or between cells. MF
GO:0042871 D-galactarate transport The directed movement of D-galactarate into, out of, within or between cells. D-galactarate is the dextrorotatory isomer of galactarate, the anion of galactaric acid. BP
GO:0042870 D-glucarate transport The directed movement of D-glucarate, the dextrorotatory isomer of glucarate, into, out of, within or between cells. BP
GO:0042873 aldonate transport The directed movement of aldonate into, out of, within or between cells. BP
GO:0042872 D-galactarate biosynthetic process The chemical reactions and pathways resulting in the formation of D-galactarate, the dextrorotatory isomer of the anion of galactaric acid. BP
GO:0042879 aldonate transporter activity Enables the directed movement of aldonate into, out of, within or between cells. MF
GO:0042878 D-glucarate transporter activity Enables the directed movement of D-glucarate, the dextrorotatory isomer of glucarate, into, out of, within or between cells. MF
GO:0055021 regulation of cardiac muscle growth Any process that modulates the frequency, rate or extent of cardiac muscle growth. BP
GO:0050379 UDP-glucuronate 5'-epimerase activity Catalysis of the reaction: UDP-glucuronate = UDP-L-iduronate. MF
GO:0050378 UDP-glucuronate 4-epimerase activity Catalysis of the reaction: UDP-glucuronate = UDP-D-galacturonate. MF
GO:0050371 tyrosine phenol-lyase activity Catalysis of the reaction: L-tyrosine + H2O = phenol + pyruvate + NH3. MF
GO:0050370 tyrosine N-monooxygenase activity Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O. MF
GO:0050373 UDP-arabinose 4-epimerase activity Catalysis of the reaction: UDP-L-arabinose = UDP-D-xylose. MF
GO:0050372 ubiquitin-calmodulin ligase activity Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin. MF
GO:0050374 UDP-galacturonate decarboxylase activity Catalysis of the reaction: UDP-D-galacturonate = UDP-L-arabinose + CO2. MF
GO:0050377 UDP-glucose 4,6-dehydratase activity Catalysis of the reaction: UDP-glucose = UDP-4-dehydro-6-deoxy-D-glucose + H2O. MF
GO:0050376 UDP-glucosamine 4-epimerase activity Catalysis of the reaction: UDP-glucosamine = UDPgalactosamine. MF
GO:0042716 chromatophore A pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria which is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. CC
GO:0042717 chromatophore membrane The lipid bilayer surrounding a chromatophore, a pigment-bearing vesicle found in certain photosynthetic bacteria and cyanobacteria. CC
GO:0004293 tissue kallikrein activity Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds. MF
GO:0042712 paternal behavior Male behaviors associated with the care and rearing offspring. BP
GO:0042713 sperm ejaculation The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. BP
GO:0051778 ent-7-alpha-hydroxykaurenoate oxidase activity Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). MF
GO:0051779 gibberellin 12-aldehyde oxidase activity Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + O2 = gibberellin 12 (GA12) + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). MF
GO:0051776 detection of redox state The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state is used to describe the balance of NAD+/NADH and NADP+/NADPH in a biological system such as a cell or organ. The redox state is reflected in the balance of several sets of metabolites (e.g., lactate and pyruvate, beta-hydroxybutyrate and acetoacetate) whose interconversion is dependent on these ratios. BP
GO:0051777 ent-kaurenoate oxidase activity Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). MF
GO:0051774 negative regulation of nitric-oxide synthase 2 biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2. BP
GO:0051775 response to redox state A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. The term redox state is used to describe the balance of NAD+/NADH and NADP+/NADPH in a biological system such as a cell or organ. The redox state is reflected in the balance of several sets of metabolites (e.g., lactate and pyruvate, beta-hydroxybutyrate and acetoacetate) whose interconversion is dependent on these ratios. BP
GO:0051772 regulation of nitric-oxide synthase 2 biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2. BP
GO:0051773 positive regulation of nitric-oxide synthase 2 biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase 2. BP
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase. BP
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase. BP
GO:0007103 spindle pole body duplication in nuclear envelope Construction of a new spindle pole body adjacent to the existing spindle pole body in the nuclear envelope; usually occurs about the time of bud emergence. BP
GO:0007100 mitotic centrosome separation Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. BP
GO:0007101 male meiosis centrosome cycle Centrosome duplication and separation in the context of male meiosis. BP
GO:0007107 membrane addition at site of cytokinesis The processes involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. BP
GO:0007105 cytokinesis, site selection The process of marking the place where cytokinesis will occur. BP
GO:0007108 cytokinesis, initiation of separation The process involved in starting cell separation. BP
GO:0007109 cytokinesis, completion of separation The process of finishing cell separation, which results in two physically separated cells. BP
GO:0016533 cyclin-dependent protein kinase 5 activator complex Activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits. CC
GO:0008603 cAMP-dependent protein kinase regulator activity Modulation of the activity of the enzyme cAMP-dependent protein kinase. MF
GO:0010331 gibberellin binding activity Interacting selectively with gibberellins, plant hormones that regulate aspects of plant growth. MF
GO:0010330 cellulose synthase complex (sensu Viridiplantae) The multimeric protein complex, organized in rosette, which catalyzes the biosynthesis of cellulose. CC
GO:0032838 cell projection cytoplasm All of the contents of a cell projection, excluding the plasma membrane surrounding the projection. CC
GO:0032839 dendrite cytoplasm All of the contents of a dendrite, excluding the surrounding plasma membrane. CC
GO:0032836 glomerular basement membrane development The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration. BP
GO:0032837 distributive segregation The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a "backup" mechanism to ensure the segregation of homologs that have failed to cross over -- either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) -- but nevertheless segregate normally. BP
GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response. BP
GO:0032835 glomerulus development NA BP
GO:0032832 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response. BP
GO:0032833 negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response Any process that stops, prevents or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response. BP
GO:0032830 negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. BP
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells. BP
GO:0015462 protein-transporting ATPase activity Catalysis of the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in). MF
GO:0015460 transport accessory protein activity NA MF
GO:0015467 G-protein activated inward rectifier potassium channel activity NA MF
GO:0015464 acetylcholine receptor activity Combining with acetylcholine to initiate a change in cell activity. MF
GO:0017068 glutamyl-tRNA(Gln) amidotransferase activity NA MF
GO:0051948 negative regulation of glutamate uptake during transmission of nerve impulse Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell. BP
GO:0047548 2-methyleneglutarate mutase activity Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate. MF
GO:0047549 2-nitrophenol 2-monooxygenase activity Catalysis of the reaction: 2-nitrophenol + NADPH + H+ + O2 = catechol + NO2(-) (nitrite) + NADP+ + H2O. MF
GO:0047546 2-hydroxypyridine 5-monooxygenase activity Catalysis of the reaction: 2-hydroxypyridine + donor-H2 + O2 = 2,5-dihydroxypyridine + acceptor + H2O. MF
GO:0047547 2-methylcitrate dehydratase activity Catalysis of the reaction: 2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O. MF
GO:0047544 2-hydroxybiphenyl 3-monooxygenase activity Catalysis of the reaction: 2-hydroxybiphenyl + NADH + H+ + O2 = 2,3-dihydroxybiphenyl + NAD+ + H2O. MF
GO:0047545 2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. MF
GO:0047542 2-furoyl-CoA dehydrogenase activity Catalysis of the reaction: 2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor. MF
GO:0047543 2-hexadecenal reductase activity Catalysis of the reaction: hexadecanal + NADP+ = 2-trans-hexadecenal + NADPH + H+. MF
GO:0047540 2-enoate reductase activity Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+. MF
GO:0047541 2-furoate-CoA ligase activity Catalysis of the reaction: ATP + 2-furoate + CoA = AMP + diphosphate + 2-furoyl-CoA. MF
GO:0051941 regulation of amino acid uptake during transmission of nerve impulse Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell. BP
GO:0043258 laminin-9 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha4, beta2 and gamma1. CC
GO:0051940 regulation of catecholamine uptake during transmission of nerve impulse Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. BP
GO:0043256 laminin complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes. CC
GO:0043257 laminin-8 complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha2, beta1 and gamma1. CC
GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. BP
GO:0043255 regulation of carbohydrate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. BP
GO:0043252 sodium-independent organic anion transport The directed, sodium-independent, movement of organic anions into, out of, within or between cells. BP
GO:0043253 chloroplast ribosome A ribosome contained within a chloroplast. CC
GO:0043250 sodium-dependent organic anion transporter activity Enables the directed movement of organic anions into, out of, within or between cells in a sodium dependent manner. MF
GO:0043251 sodium-dependent organic anion transport The directed, sodium-dependent, movement of organic anions into, out of, within or between cells. BP
GO:0017063 phosphatidylserine-specific phospholipase A1 activity Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion. MF
GO:0017064 fatty acid amide hydrolase activity NA MF
GO:0017065 single-strand selective uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA. MF
GO:0017067 tyrosine-ester sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate. MF
GO:0015347 sodium-independent organic anion transporter activity Enables the directed movement of organic anions into, out of, within or between cells in a sodium independent manner. MF
GO:0045940 positive regulation of steroid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. BP
GO:0045941 positive regulation of transcription Any process that activates or increases the frequency, rate or extent of transcription. BP
GO:0045942 negative regulation of phosphorus utilization Any process that stops, prevents or reduces the frequency, rate or extent of phosphorus utilization. BP
GO:0045943 positive regulation of transcription from RNA polymerase I promoter Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase I promoter. BP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter. BP
GO:0045945 positive regulation of transcription from RNA polymerase III promoter Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase III promoter. BP
GO:0045947 negative regulation of translational initiation Any process that stops, prevents or reduces the frequency, rate or extent of translational initiation. BP
GO:0045948 positive regulation of translational initiation Any process that activates or increases the frequency, rate or extent of translational initiation. BP
GO:0045949 positive regulation of phosphorus utilization Any process that activates or increases the frequency, rate or extent of phosphorus utilization. BP
GO:0015345 ferric enterobactin:hydrogen symporter activity Catalysis of the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in). MF
GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex The heterodimeric receptor for granulocyte macrophage colony-stimulating factor. CC
GO:0030527 structural constituent of chromatin The action of a molecule that contributes to the structural integrity of chromatin. MF
GO:0030522 intracellular receptor-mediated signaling pathway Any series of molecular signals initiated by a ligand entering the target cell, where it binds to an intracellular receptor. BP
GO:0030523 dihydrolipoamide S-acyltransferase activity Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide. MF
GO:0030520 estrogen receptor signaling pathway Any series of molecular signals generated as a consequence of an estrogen binding to its receptor. BP
GO:0030521 androgen receptor signaling pathway Any series of molecular signals generated as a consequence of an androgen binding to its receptor. BP
GO:0030528 transcription regulator activity Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. MF
GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. CC
GO:0046376 GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate. BP
GO:0016325 oocyte microtubule cytoskeleton organization Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. The MTOC nucleates a microtubule network that extends through the ring canals into the 15 nurse cells of the cyst. BP
GO:0046375 K antigen metabolic process The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. BP
GO:0046372 D-arabinose metabolic process The chemical reactions and pathways involving D-arabinose, the dextrorotatory isomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides. BP
GO:0046373 L-arabinose metabolic process The chemical reactions and pathways involving L-arabinose, the levorotatory isomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc. BP
GO:0016322 neuron remodeling The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. BP
GO:0016323 basolateral plasma membrane Part of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. CC
GO:0009199 ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety. BP
GO:0009198 pyrimidine deoxyribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009192 deoxyribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009191 ribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009190 cyclic nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. BP
GO:0009197 pyrimidine deoxyribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009196 pyrimidine deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009195 pyrimidine ribonucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0009194 pyrimidine ribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety. BP
GO:0008240 tripeptidyl-peptidase activity NA MF
GO:0008241 peptidyl-dipeptidase activity Catalysis of the release of C-terminal dipeptides from a polypeptide chain. MF
GO:0008242 omega peptidase activity Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of a-carboxyl to a-amino groups). MF
GO:0008243 plasminogen activator activity Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin. MF
GO:0008247 2-acetyl-1-alkylglycerophosphocholine esterase complex An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF). CC
GO:0032319 regulation of Rho GTPase activity Any process that modulates the activity of a GTPase of the Rho family. BP
GO:0032318 regulation of Ras GTPase activity Any process that modulates the activity of a GTPase of the Ras superfamily. BP
GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. BP
GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. BP
GO:0032311 angiogenin-PRI complex A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis. CC
GO:0032310 prostaglandin secretion The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring. BP
GO:0032317 regulation of Rap GTPase activity Any process that modulates the activity of a GTPase of the Rap family. BP
GO:0032316 regulation of Ran GTPase activity Any process that modulates the activity of a GTPase of the Ran family. BP
GO:0032315 regulation of Ral GTPase activity Any process that modulates the activity of a GTPase of the Ral family. BP
GO:0032314 regulation of Rac GTPase activity Any process that modulates the activity of a GTPase of the Rac family. BP
GO:0046998 (S)-usnate reductase activity Catalysis of the reaction: L-usnic acid + NADH + H+ = NAD+ + 2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-3-hydroxy-6-methyl-cyclohexa-2,4-dienone. MF
GO:0046999 regulation of conjugation Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual. BP
GO:0046992 oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y. MF
GO:0046993 oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen. MF
GO:0046990 N-hydroxyarylamine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine. MF
GO:0046991 hydroxynitrilase activity Catalysis of the reaction: 2-hydroxyisobutyronitrile = cyanide + acetone. MF
GO:0046996 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated. MF
GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin. MF
GO:0046994 oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound. MF
GO:0046995 oxidoreductase activity, acting on hydrogen as donor, with other known acceptors Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound. MF
GO:0019929 peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid The posttranslational cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid. BP
GO:0019928 peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid The posttranslational cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid. BP
GO:0019923 alpha-1-microglobulin-chromophore linkage The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds. BP
GO:0019922 protein-chromophore linkage via peptidyl-cysteine The covalent linking of a chromophore to a protein via peptidyl-cysteines. BP
GO:0019921 peptidyl-1-thioglycine biosynthetic process, carboxy-terminal The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond. BP
GO:0019920 peptidyl-1-thioglycine biosynthetic process, internal The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide. BP
GO:0019927 peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone The posttranslational cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase. BP
GO:0019926 peptidyl-tryptophan oxidation to tryptophyl quinone The posttranslational oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine. BP
GO:0002529 regulation of plasma kallikrein-kinin cascade Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade. BP
GO:0002528 regulation of vascular permeability during acute inflammatory response Any process that modulates the extent to which blood vessels can be pervaded by fluid during an acute inflammatory response. BP
GO:0002527 vasodilation during acute inflammatory response An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure during an acute inflammatory response. BP
GO:0002526 acute inflammatory response Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. BP
GO:0002525 acute inflammatory response to non-antigenic stimulus An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma. BP
GO:0002524 hypersensitivity An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system. BP
GO:0002523 leukocyte migration during inflammatory response The movement of leukocytes within or between different tissues and organs of the body during an inflammatory response. BP
GO:0002522 leukocyte migration during immune response The movement of leukocytes within or between different tissues and organs of the body during an immune response. BP
GO:0002521 leukocyte differentiation The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages. BP
GO:0002520 immune system development The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. BP
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity NA MF
GO:0005000 vasopressin receptor activity Combining with vasopressin to initiate a change in cell activity. MF
GO:0005003 ephrin receptor activity Combining with an ephrin to initiate a change in cell activity. MF
GO:0042215 anaerobic phenol metabolic process The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. BP
GO:0042214 terpene metabolic process The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups. A monoterpene is made up of two units, a sesquiterpene three units, and a diterpene is made up of four units. Terpenes are widely used as flavorings, deodorants, and medicines (as in the treatment of acne). BP
GO:0042217 1-aminocyclopropane-1-carboxylate catabolic process The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. BP
GO:0042216 phenanthrene catabolic process The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon. BP
GO:0042211 dimethylsilanediol catabolic process The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. BP
GO:0042210 octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter. BP
GO:0042213 m-cresol catabolic process The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol. BP
GO:0042212 cresol metabolic process The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. BP
GO:0006523 alanine biosynthetic process The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. BP
GO:0006522 alanine metabolic process The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. BP
GO:0006521 regulation of amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. BP
GO:0006520 amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. BP
GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-guanidinopentanoic acid, a chiral alpha-amino acid found in peptide linkage in proteins. BP
GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-guanidinopentanoic acid, a chiral alpha-amino acid found in peptide linkage in proteins. BP
GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-guanidinopentanoic acid. BP
GO:0006524 alanine catabolic process The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid. BP
GO:0003735 structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome. MF
GO:0003730 mRNA 3'-UTR binding Interacting selectively with the 3' untranslated region of an mRNA molecule. MF
GO:0005004 GPI-linked ephrin receptor activity NA MF
GO:0000279 M phase Progression through M phase, the part of the cell cycle comprising nuclear division and cytokinesis. BP
GO:0000278 mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M. BP
GO:0000275 proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0000274 proton-transporting ATP synthase, stator stalk (sensu Eukaryota) One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0000277 [cytochrome c]-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c. MF
GO:0000276 proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0000271 polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. BP
GO:0000270 peptidoglycan metabolic process The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network. BP
GO:0000273 lipoic acid metabolic process The chemical reactions and pathways involving lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids. BP
GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. BP
GO:0004969 histamine receptor activity Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. MF
GO:0004968 gonadotropin-releasing hormone receptor activity Combining with gonadotropin-releasing hormone to initiate a change in cell activity. MF
GO:0004965 GABA-B receptor activity Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. MF
GO:0004964 lutropin-choriogonadotropic hormone receptor activity Combining with lutropin-choriogonadotropic hormone to initiate a change in cell activity. MF
GO:0004967 glucagon receptor activity Combining with glucagon to initiate a change in cell activity. MF
GO:0004966 galanin receptor activity Combining with galanin to initiate a change in cell activity. MF
GO:0004961 thromboxane A2 receptor activity Combining with thromboxane A2 (TXA(2)) to initiate a change in cell activity. MF
GO:0004960 thromboxane receptor activity Combining with a thromboxane (TXA) to initiate a change in cell activity. MF
GO:0004963 follicle-stimulating hormone receptor activity Combining with follicle-stimulating hormone to initiate a change in cell activity. MF
GO:0004962 endothelin receptor activity Combining with endothelin to initiate a change in cell activity. MF
GO:0050999 regulation of nitric-oxide synthase activity Any process that modulates the activity of the enzyme nitric-oxide synthase. BP
GO:0050998 nitric-oxide synthase binding Interacting selectively with the enzyme nitric-oxide synthase. MF
GO:0050991 enzyme active site formation via O-sulfo-L-threonine The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine. BP
GO:0050990 N-terminal protein amino acid carbamoylation The carbamoylation of the N-terminal amino acid of proteins. BP
GO:0050993 dimethylallyl diphosphate metabolic process The chemical reactions and pathways involving dimethylallyl diphosphate. BP
GO:0050992 dimethylallyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate. BP
GO:0050995 negative regulation of lipid catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. BP
GO:0050994 regulation of lipid catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. BP
GO:0050997 quaternary ammonium group binding Interacting selectively with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. MF
GO:0050996 positive regulation of lipid catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. BP
GO:0005006 epidermal growth factor receptor activity Combining with an epidermal growth factor to initiate a change in cell activity. MF
GO:0002068 glandular epithelial cell development The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. BP
GO:0002069 columnar/cuboidal epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. BP
GO:0002062 chondrocyte differentiation The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. BP
GO:0002063 chondrocyte development The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. BP
GO:0002060 purine binding Interacting selectively with a purine, an organic nitrogenous base. MF
GO:0002061 pyrimidine binding Interacting selectively with a pyrimidine, an organic nitrogenous base. MF
GO:0002066 columnar/cuboidal epithelial cell development The process whose specific outcome is the progression of an columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. BP
GO:0002067 glandular epithelial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. BP
GO:0002064 epithelial cell development The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. BP
GO:0002065 columnar/cuboidal epithelial cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. BP
GO:0051118 glucan endo-1,3-alpha-glucosidase activity Catalysis of the endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran. MF
GO:0051119 sugar transporter activity Enables the directed movement of a sugar into, out of, within or between cells. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. MF
GO:0004381 fucosylgalactoside 3-alpha-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. MF
GO:0004380 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. MF
GO:0004383 guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. MF
GO:0051115 enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine). BP
GO:0004385 guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP. MF
GO:0051113 enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine). BP
GO:0051110 peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine). BP
GO:0051111 peptidyl-histidine adenylylation The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine). BP
GO:0010038 response to metal ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. BP
GO:0010039 response to iron ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. BP
GO:0010036 response to boron A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron stimulus. BP
GO:0010037 response to carbon dioxide A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. BP
GO:0010034 response to acetate A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. BP
GO:0010035 response to inorganic substance A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. BP
GO:0010032 meiotic chromosome condensation Compaction of chromatin structure prior to meiosis in eukaryotic cells. BP
GO:0010033 response to organic substance A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. BP
GO:0010030 positive regulation of seed germination Any process that activates or increase the rate of seed germination. BP
GO:0010031 circumnutation The spiral movement of a plant organ during growth. BP
GO:0018209 peptidyl-serine modification The modification of peptidyl-serine. BP
GO:0018208 peptidyl-proline modification The modification of peptidyl-proline. BP
GO:0018205 peptidyl-lysine modification The modification of peptidyl-lysine. BP
GO:0018204 peptidyl-leucine modification The modification of peptidyl-leucine. BP
GO:0018207 peptidyl-phenylalanine modification The modification of peptidyl-phenylalanine. BP
GO:0018206 peptidyl-methionine modification The modification of peptidyl-methionine. BP
GO:0018201 peptidyl-glycine modification The modification of peptidyl-glycine. BP
GO:0018200 peptidyl-glutamic acid modification The modification of peptidyl-glutamic acid. BP
GO:0018203 peptidyl-isoleucine modification The modification of peptidyl-isoleucine. BP
GO:0018202 peptidyl-histidine modification The modification of peptidyl-histidine. BP
GO:0005382 transmembrane iron ion permease activity NA MF
GO:0005381 iron ion transporter activity Enables the directed movement of iron (Fe) ions into, out of, within or between cells. MF
GO:0005386 carrier activity Catalysis of the transfer of a specific substance or related group of substances from one side of the membrane to the other. MF
GO:0005384 manganese ion transporter activity Enables the directed movement of manganese (Mn) ions into, out of, within or between cells. MF
GO:0005385 zinc ion transporter activity Enables the directed movement of zinc (Zn) ions into, out of, within or between cells. MF
GO:0005388 calcium-transporting ATPase activity Catalysis of the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). MF
GO:0004033 aldo-keto reductase activity Catalysis of the NADPH-dependent reduction of carbonyl compounds. MF
GO:0004032 aldehyde reductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. MF
GO:0004031 aldehyde oxidase activity Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + H2O2. MF
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. MF
GO:0004037 allantoicase activity Catalysis of the reaction: allantoate + H2O = (-)-ureidoglycolate + urea. MF
GO:0004036 alkylbase DNA glycosidase activity NA MF
GO:0004035 alkaline phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate. MF
GO:0004034 aldose 1-epimerase activity Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. MF
GO:0004039 allophanate hydrolase activity Catalysis of the reaction: urea-1-carboxylate + H2O = 2 CO2 + 2 NH3. MF
GO:0004038 allantoinase activity Catalysis of the reaction: allantoin + H2O = allantoate. MF
GO:0001609 adenosine receptor activity, G-protein coupled NA MF
GO:0001608 nucleotide receptor activity, G-protein coupled A GPCR that binds a nucleotide or nucleotide derivative as its ligand. MF
GO:0001603 vasopressin-like receptor activity NA MF
GO:0001602 pancreatic polypeptide receptor activity Combining with pancreatic polypeptide PP to initiate a change in cell activity. MF
GO:0001601 peptide YY receptor activity Combining with gut peptide YY to initiate a change in cell activity. MF
GO:0001600 endothelin-B receptor activity A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity. MF
GO:0001607 neuromedin U receptor activity Combining with neuromedin U to initiate a change in cell activity. MF
GO:0001606 GPR37/endothelin B-like receptor activity NA MF
GO:0001605 adrenomedullin receptor activity Combining with adrenomedullin to initiate a change in cell activity. MF
GO:0001604 urotensin II receptor activity NA MF
GO:0006893 Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. BP
GO:0006892 post-Golgi vesicle-mediated transport The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. BP
GO:0006891 intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). BP
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by COP I vesicles. BP
GO:0006897 endocytosis The uptake of external materials by cells by the invagination of small region of the plasma membrane to form a new intracellular membrane-limited vesicle. BP
GO:0006896 Golgi to vacuole transport The directed movement of substances from the Golgi to the vacuole. BP
GO:0006895 Golgi to endosome transport The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. BP
GO:0006894 Golgi to secretory vesicle transport The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release. BP
GO:0006898 receptor-mediated endocytosis The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. BP
GO:0019552 glutamate catabolic process via 2-hydroxyglutarate The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP. BP
GO:0019553 glutamate catabolic process via L-citramalate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate. BP
GO:0019550 glutamate catabolic process to aspartate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate. BP
GO:0019551 glutamate catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate. BP
GO:0019556 histidine catabolic process to glutamate and formamide The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide. BP
GO:0019557 histidine catabolic process to glutamate and formate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate. BP
GO:0019554 glutamate catabolic process to oxaloacetate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate. BP
GO:0019555 glutamate catabolic process to ornithine The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine. BP
GO:0019558 histidine catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate. BP
GO:0019559 histidine catabolic process to imidazol-5-yl-lactate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate. BP
GO:0016064 immunoglobulin mediated immune response An immune response mediated by immunoglobulins, whether cell-bound or in solution. BP
GO:0016063 rhodopsin biosynthetic process The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. BP
GO:0016062 adaptation of rhodopsin mediated signaling Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation. BP
GO:0016061 regulation of light-activated channel activity Any process that modulates the frequency, rate or extent of light-activated channel activity. BP
GO:0016060 metarhodopsin inactivation Process by which metarhodopsin is prevented from generating molecular signals. BP
GO:0009819 drought recovery A change in state or activity of a cell or an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition. BP
GO:0005818 aster An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores. CC
GO:0005819 spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. CC
GO:0005813 centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. CC
GO:0005811 lipid particle Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins. CC
GO:0005816 spindle pole body The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. CC
GO:0005814 centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. CC
GO:0005815 microtubule organizing center A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. CC
GO:0015868 purine ribonucleotide transport The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell. BP
GO:0015869 DNA-protein complex transport The directed movement of DNA-protein complexes into, out of, within or between cells. BP
GO:0015866 ADP transport The directed movement of ADP, adenosine diphosphate, into, out of, within or between cells. BP
GO:0015867 ATP transport The directed movement of ATP, adenosine triphosphate, into, out of, within or between cells. BP
GO:0015864 pyrimidine nucleoside transport The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells. BP
GO:0015865 purine nucleotide transport The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. BP
GO:0015862 uridine transport The directed movement of uridine, uracil riboside, into, out of, within or between cells. BP
GO:0015863 xanthosine transport The directed movement of xanthosine, xanthine riboside, into, out of, within or between cells. BP
GO:0015860 purine nucleoside transport The directed movement of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells. BP
GO:0015861 cytidine transport The directed movement of cytidine, cytosine riboside, into, out of, within or between cells. BP
GO:0051929 positive regulation of calcium ion transport via voltage gated calcium channel Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel. BP
GO:0051928 positive regulation of calcium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells. BP
GO:0051927 negative regulation of calcium ion transport via voltage gated calcium channel Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel. BP
GO:0051926 negative regulation of calcium ion transport Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells. BP
GO:0051925 regulation of calcium ion transport via voltage-gated calcium channel Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel. BP
GO:0051924 regulation of calcium ion transport Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells. BP
GO:0051923 sulfation The addition of a sulfate group to a molecule. BP
GO:0051922 cholesterol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate. MF
GO:0051921 adenosylcobyric acid synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate. MF
GO:0051920 peroxiredoxin activity Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. MF
GO:0048778 regulation of erythrophore differentiation Any process that modulates the frequency, rate or extent of erythrophore differentiation. BP
GO:0005149 interleukin-1 receptor binding Interacting selectively with the interleukin-1 receptor. MF
GO:0046527 glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. MF
GO:0046526 D-xylulose reductase activity Catalysis of the reaction: xylitol + NAD+ = D-xylulose + NADH + H+. MF
GO:0046525 xylosylprotein 4-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein. MF
GO:0005144 interleukin-13 receptor binding Interacting selectively with the interleukin-13 receptor. MF
GO:0046524 sucrose-phosphate synthase activity Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. MF
GO:0005145 interleukin-14 receptor binding Interacting selectively with the interleukin-14 receptor. MF
GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity Catalysis of the reaction: 5-methylthio-5-deoxy-D-ribose 1-phosphate = 5-methylthio-5-deoxy-D-ribulose 1-phosphate. MF
GO:0003963 RNA-3'-phosphate cyclase activity Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. MF
GO:0048776 negative regulation of leucophore differentiation Any process that stops, prevents or reduces the frequency, rate or extent of leucophore differentiation. BP
GO:0046522 S-methyl-5-thioribose kinase activity Catalysis of the reaction: ATP + S5-methyl-5-thio-D-ribose = ADP + S5-methyl-5-thio-D-ribose 1-phosphate. MF
GO:0005147 oncostatin-M receptor binding Interacting selectively with the oncostatin-M receptor. MF
GO:0046521 sphingoid catabolic process The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. BP
GO:0005140 interleukin-9 receptor binding Interacting selectively with the interleukin-9 receptor. MF
GO:0046520 sphingoid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. BP
GO:0005141 interleukin-10 receptor binding Interacting selectively with the interleukin-10 receptor. MF
GO:0005142 interleukin-11 receptor binding Interacting selectively with the interleukin-11 receptor. MF
GO:0005143 interleukin-12 receptor binding Interacting selectively with the interleukin-12 receptor. MF
GO:0019478 D-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of D-amino acids, the dextrorotatory isomer of amino acids. BP
GO:0008009 chemokine activity The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. MF
GO:0008004 lamina reticularis A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue. CC
GO:0008002 lamina lucida The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina. CC
GO:0008003 lamina densa The electron-dense layer of the basal lamina; lies just below the lamina lucida. CC
GO:0016881 acid-amino acid ligase activity NA MF
GO:0016880 acid-ammonia (or amide) ligase activity NA MF
GO:0016882 cyclo-ligase activity NA MF
GO:0016885 ligase activity, forming carbon-carbon bonds Catalysis of the ligation of two substances via a carbon-carbon bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. MF
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. MF
GO:0016887 ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. MF
GO:0016886 ligase activity, forming phosphoric ester bonds Catalysis of the ligation of two substances via a phosphoric ester bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. MF
GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. MF
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. MF
GO:0014014 negative regulation of gliogenesis Any process that stops, prevents or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. BP
GO:0014015 positive regulation of gliogenesis Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. BP
GO:0014016 neuroblast differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. BP
GO:0014017 neuroblast fate commitment The process whereby the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast. BP
GO:0014010 Schwann cell proliferation The multiplication or reproduction of Schwann cells, resulting in the rapid expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. BP
GO:0014011 Schwann cell proliferation involved in axon regeneration The multiplication or reproduction of Schwann cells by cell division, resulting in the rapid expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system. BP
GO:0014012 axon regeneration in the peripheral nervous system The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury. BP
GO:0014013 regulation of gliogenesis Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. BP
GO:0014018 neuroblast fate specification The process whereby a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. BP
GO:0014019 neuroblast development The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. BP
GO:0042814 monopolar cell growth Polarized growth from one end of a cell. BP
GO:0045337 farnesyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. BP
GO:0045336 clathrin-coated phagocytic vesicle A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. CC
GO:0045335 phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. CC
GO:0045334 clathrin-coated endocytic vesicle A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. CC
GO:0045333 cellular respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). BP
GO:0045332 phospholipid translocation The translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. BP
GO:0045330 aspartyl esterase activity NA MF
GO:0045339 farnesyl diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate. BP
GO:0045338 farnesyl diphosphate metabolic process The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation. BP
GO:0015058 epidermal growth factor-like module containing hormone receptor activity NA MF
GO:0015057 thrombin receptor activity Combining with thrombin to initiate a change in cell activity. MF
GO:0015056 corticotrophin-releasing factor receptor activity Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. MF
GO:0015055 secretin receptor activity Combining with secretin to initiate a change in cell activity. MF
GO:0015054 gastrin receptor activity Combining with gastrin to initiate a change in cell activity. MF
GO:0015052 beta3-adrenergic receptor activity NA MF
GO:0015051 X-opioid receptor activity NA MF
GO:0015050 methane monooxygenase complex A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized. CC
GO:0035217 labial disc development Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis. BP
GO:0035216 haltere disc development Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. BP
GO:0035215 genital disc development Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia. BP
GO:0035214 eye-antennal disc development Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps. BP
GO:0035213 clypeo-labral disc development The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite. BP
GO:0035212 cell competition (sensu Metazoa) Competitive interactions within multicellular organisms betweeen cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells. As in, but not restricted to, animals (Metazoa, ncbi_taxonomy_id:33208). BP
GO:0035211 spermathecum morphogenesis The process by which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk. BP
GO:0035210 prepupal development (sensu Insecta) The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects which undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0035219 prothoracic disc development Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle. BP
GO:0035218 leg disc development Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura. BP
GO:0043595 endospore cortex A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan. CC
GO:0043594 outer endospore membrane The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat. CC
GO:0043597 replication fork (sensu Bacteria and Archaea) The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0043596 replication fork (sensu Eukaryota) The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0016508 long-chain-enoyl-CoA hydratase activity Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. MF
GO:0043590 bacterial nucleoid The region of a bacterial cell to which the DNA is confined. CC
GO:0046518 octamethylcyclotetrasiloxane metabolic process The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom. BP
GO:0043592 exosporium The outer-most layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid. CC
GO:0046516 hypusine metabolic process The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. BP
GO:0046517 octamethylcyclotetrasiloxane catabolic process The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom. BP
GO:0046514 ceramide catabolic process The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. BP
GO:0046515 hypusine biosynthetic process The chemical reactions and pathways resulting in the formation of hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. BP
GO:0043599 DNA replication factor C complex (sensu Eukaryota) A complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0043598 DNA replication factor C complex (sensu Bacteria and Archaea) A complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0016502 nucleotide receptor activity Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. MF
GO:0046511 sphinganine biosynthetic process The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol. BP
GO:0043049 otic placode formation The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain. BP
GO:0043048 dolichyl monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative. BP
GO:0043047 single-stranded telomeric DNA binding Interacting selectively with single-stranded telomere-associated DNA. MF
GO:0043046 DNA methylation during gametogenesis The covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established. BP
GO:0043045 DNA methylation during embryonic development The covalent transfer of a methyl group to C-5 of cytosine during embryogenesis, when DNA methylation patterns are established. BP
GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. BP
GO:0043043 peptide biosynthetic process The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. BP
GO:0043042 amino acid adenylylation by nonribosomal peptide synthase Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor. BP
GO:0043041 nonribosomal amino acid activation Activation of an amino acid for incorporation into a peptide by a nonribosomal process. BP
GO:0043040 tRNA aminoacylation for nonribosomal peptide biosynthetic process The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis. BP
GO:0030199 collagen fibril organization Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. BP
GO:0030198 extracellular matrix organization and biogenesis The assembly and arrangement of an extracellular matrix. BP
GO:0030193 regulation of blood coagulation Any process that modulates the frequency, rate or extent of blood coagulation. BP
GO:0030192 Hsp70/Hsc70 protein regulator activity Modulates the activity of chaperones of the Hsp70/Hsc70 class. MF
GO:0030191 Hsp70/Hsc70 protein inhibitor activity Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class. MF
GO:0030190 chaperone inhibitor activity Stops, prevents or reduces the activity of a molecular chaperone. MF
GO:0030197 extracellular matrix constituent, lubricant activity Functions as a lubricant for an extracellular matrix, such as a mucous membrane. MF
GO:0030196 cyanide hydratase activity Catalysis of the reaction: formamide = cyanide + H2O. MF
GO:0030195 negative regulation of blood coagulation Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation. BP
GO:0030194 positive regulation of blood coagulation Any process that activates or increases the frequency, rate or extent of blood coagulation. BP
GO:0031248 protein acetyltransferase complex A complex that catalyses the transfer of an acetyl group to a protein acceptor molecule. CC
GO:0031249 denatured protein binding Interacting selectively with denatured proteins. MF
GO:0031240 external side of outer membrane The side of the outer membrane that is opposite to the side that faces the periplasm. CC
GO:0031241 internal side of outer membrane The side of the outer membrane that faces the periplasm. CC
GO:0031242 extrinsic to external side of outer membrane Loosely bound to the surface of the outer membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region. CC
GO:0031243 intrinsic to external side of outer membrane Located in the outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the periplasm. CC
GO:0031244 extrinsic to outer membrane (sensu ProteoBacteria) Loosely bound to one surface of the outer membrane, but not integrated into the hydrophobic region. As in, but not restricted to, the Gram-negative bacteria (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0031245 extrinsic to internal side of outer membrane Loosely bound to the surface of the outer membrane that faces the cytoplasm, but not integrated into the hydrophobic region. CC
GO:0031246 intrinsic to internal side of outer membrane Located in the outer membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the periplasm. CC
GO:0031247 actin rod formation The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules. BP
GO:0048370 lateral mesoderm formation The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. BP
GO:0048371 lateral mesodermal cell differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell. BP
GO:0048372 lateral mesodermal cell fate commitment The process by which a cell becomes committed to become a lateral mesoderm cell. BP
GO:0048373 lateral mesodermal cell fate determination Process by which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0048374 regulation of lateral mesodermal cell fate determination Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination. BP
GO:0048375 negative regulation of lateral mesodermal cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of lateral mesoderm cell fate determination. BP
GO:0048376 positive regulation of lateral mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination. BP
GO:0048377 lateral mesodermal cell fate specification Process by which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. BP
GO:0048378 regulation of lateral mesodermal cell fate specification Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification. BP
GO:0048379 positive regulation of lateral mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification. BP
GO:0009016 succinyldiaminopimelate transaminase activity Catalysis of the reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate. MF
GO:0009017 succinylglutamate desuccinylase activity NA MF
GO:0009014 succinyl-diaminopimelate desuccinylase activity Catalysis of the reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate. MF
GO:0009015 succinylarginine dihydrolase activity NA MF
GO:0009012 streptomycin 3''-adenylyltransferase activity Catalysis of the reaction: ATP + streptomycin = diphosphate + 3''-adenylylstreptomycin. MF
GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. MF
GO:0050526 poly(3-hydroxybutyrate) depolymerase activity Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x = 1-5. MF
GO:0009011 starch synthase activity Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). MF
GO:0050528 acyloxyacyl hydrolase activity Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. MF
GO:0050529 polyneuridine-aldehyde esterase activity Catalysis of the reaction: H2O + polyneuridine aldehyde = methanol + CO2 + 16-epivellosimine. MF
GO:0009018 sucrose phosphorylase activity Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate. MF
GO:0009019 tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. MF
GO:0032296 double-stranded RNA-specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. MF
GO:0032297 negative regulation of DNA replication initiation Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication. BP
GO:0032294 ensheathment of non-myelinated axons in the peripheral nervous system The process by which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons. BP
GO:0032295 ensheathment of neuronal cell bodies The process by which satellite glial cells isolate neuronal cell bodies. BP
GO:0032292 ensheathment of axons in the peripheral nervous system The process by which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. BP
GO:0032293 ensheathment of non-myelinated axons in the central nervous system The process by which a non-myelinating glial cell membrane encircles an axon in the central nervous system. BP
GO:0032290 myelin formation in the peripheral nervous system The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system. BP
GO:0032291 ensheathment of axons in the central nervous system The process by which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. BP
GO:0032298 positive regulation of DNA replication initiation Any process that activates or increases the frequency, rate or extent of initiation of DNA replication. BP
GO:0032299 ribonuclease H2 complex A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p. CC
GO:0018951 p-xylene metabolic process The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. BP
GO:0018950 o-xylene metabolic process The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon. BP
GO:0018953 p-cymene metabolic process The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants. BP
GO:0018952 parathion metabolic process The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, a caricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition. BP
GO:0018955 phenanthrene metabolic process The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish. BP
GO:0018954 pentaerythritol tetranitrate metabolic process The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator. BP
GO:0018957 phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite. BP
GO:0018956 phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite. BP
GO:0018959 aerobic phenol metabolic process The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. BP
GO:0018958 phenol metabolic process The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers. BP
GO:0040002 cuticle biosynthetic process (sensu Nematoda) Synthesis and deposition of a noncellular, hardened, or membranous secretion from an epithelial sheet, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040003 cuticle biosynthetic process (sensu Insecta) Synthesis and deposition of a noncellular, hardened, or membranous secretion from an epithelial sheet. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0040001 establishment of mitotic spindle localization The cell cycle process whereby the directed movement of the mitotic spindle to a specific location in the cell occurs. BP
GO:0040006 cuticular attachment to epithelium (sensu Protostomia and Nematoda) Attaching of a cuticle to the epithelium underlying it. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317), and the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040007 growth The increase in size or mass of an entire organism, a part of an organism or a cell. BP
GO:0040004 cuticular attachment to epithelium (sensu Nematoda) Attaching of a cuticle to the epithelium underlying it, as in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231). BP
GO:0040005 cuticular attachment to epithelium (sensu Insecta) Attaching of a cuticle to the epithelium underlying it. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0040008 regulation of growth Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. BP
GO:0040009 regulation of growth rate Any process that modulates the rate of growth of all or part of an organism. BP
GO:0044266 organismal macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. BP
GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. BP
GO:0044264 cellular polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. BP
GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells. BP
GO:0009675 high affinity sulfate:hydrogen symporter activity Catalysis of the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). Transporter with a high affinity for sulfate, that mediates the active uptake of sulfate from areas of low sulfate concentration to high sulfate concentration. MF
GO:0015030 Cajal body A class of nuclear body, first seen after silver staining by Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. CC
GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. BP
GO:0044263 organismal polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, in multicellular organisms that occur at the tissue, organ, or organismal level. BP
GO:0015032 storage protein import into fat body The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life. BP
GO:0009670 triose-phosphate transporter activity Enables the exchange of an organic three carbon compound phosphate ester for inorganic phosphate. MF
GO:0015035 protein disulfide oxidoreductase activity NA MF
GO:0044261 organismal carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms, occurring at the tissue, organ, or organismal level. BP
GO:0032128 flocculation via extracellular polymer Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment. BP
GO:0032129 histone deacetylase activity (H3-K9 specific) Catalysis of the removal of an acetyl group from lysine at position 9 of the histone H3 protein. MF
GO:0015037 peptide disulfide oxidoreductase activity NA MF
GO:0032120 prospore membrane formation The process by which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed. BP
GO:0032121 attachment of telomeres to spindle pole body The cell cycle process whereby physical connections are formed between telomeres and the spindle pole body, facilitating bouquet formation. BP
GO:0032122 oral apparatus organization and biogenesis The assembly and arrangement of the oral apparatus. BP
GO:0047264 heteroglycan alpha-mannosyltransferase activity Catalysis of the reaction: heteroglycan + GDP-mannose = 1,2(or 1,3)-alpha-D-mannosylheteroglycan + GDP. MF
GO:0032124 macronuclear organization and biogenesis The assembly and arrangement of the macronucleus. BP
GO:0032125 micronuclear organization and biogenesis The assembly and arrangement of the micronucleus. BP
GO:0032126 eisosome Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p. CC
GO:0032127 dense core granule membrane The lipid bilayer surrounding a dense core granule. CC
GO:0051441 positive regulation of ubiquitin ligase activity during meiotic cell cycle Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle. BP
GO:0009678 hydrogen-translocating pyrophosphatase activity Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. MF
GO:0044269 glycerol ether catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. BP
GO:0006286 base-excision repair, base-free sugar-phosphate removal Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme. BP
GO:0006287 base-excision repair, gap-filling Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. BP
GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. BP
GO:0006285 base-excision repair, AP site formation The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site. BP
GO:0006282 regulation of DNA repair Any process that modulates the frequency, rate or extent of DNA repair. BP
GO:0006283 transcription-coupled nucleotide-excision repair The preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the general nucleotide excision repair pathway. BP
GO:0006280 mutagenesis The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level. BP
GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. BP
GO:0006288 base-excision repair, DNA ligation The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair. BP
GO:0006289 nucleotide-excision repair In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). BP
GO:0005958 DNA-dependent protein kinase complex A large protein complex which is involved in the repair of DNA double-strand breaks and V(D)J recombination events. In mammals, it consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer, Ku, the nuclear phosphoprotein XRCC4 and DNA ligase IV. CC
GO:0005953 CAAX-protein geranylgeranyltransferase complex A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane. CC
GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. CC
GO:0005951 carbamoyl-phosphate synthase complex An enzyme complex that exists in monomer, dimer, and higher oligomeric forms. Catalysis of the reaction: 2 ATP + L-glutamine + carbon dioxide (CO2) + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. CC
GO:0005950 anthranilate synthase complex A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine. CC
GO:0005956 protein kinase CK2 complex Complex that possesses casein kinase activity, found in nearly every subcellular compartment. Protein kinase CK2 complexes are usually tetramers of two alpha and two beta subunits, and can phosphorylate many protein substrates in addition to casein. CC
GO:0005955 calcineurin complex A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. CC
GO:0005954 calcium- and calmodulin-dependent protein kinase complex An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. CC
GO:0005488 binding The selective, often stoichiometric interaction of a molecule with one or more specific sites on another molecule. MF
GO:0005485 v-SNARE activity NA MF
GO:0005484 SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. MF
GO:0005487 nucleocytoplasmic transporter activity Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. MF
GO:0005486 t-SNARE activity NA MF
GO:0005483 soluble NSF attachment protein activity Interacting selectively with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex. MF
GO:0006759 ATP regeneration NA BP
GO:0006750 glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. BP
GO:0006751 glutathione catabolic process The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. BP
GO:0006752 group transfer coenzyme metabolic process NA BP
GO:0006753 nucleoside phosphate metabolic process NA BP
GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. BP
GO:0006755 carbamoyl phosphate-ADP transphosphorylation NA BP
GO:0006756 AMP phosphorylation The process of introducing a phosphoric group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphoric groups produces ATP. BP
GO:0006757 ADP phosphorylation The process of introducing a phosphoric group into ADP, adenosine diphosphate, to produce ATP. BP
GO:0048639 positive regulation of developmental growth Any process that activates, maintains or increases the rate of developmental growth. BP
GO:0048638 regulation of developmental growth Any process that modulates the frequency, rate or extent of developmental growth. BP
GO:0048631 regulation of skeletal muscle growth Any process that modulates the frequency, rate or extent of skeletal muscle growth. BP
GO:0048630 skeletal muscle growth The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. BP
GO:0048633 positive regulation of skeletal muscle growth Any process that activates, maintains or increases the rate of skeletal muscle growth. BP
GO:0048632 negative regulation of skeletal muscle growth Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle growth. BP
GO:0048635 negative regulation of muscle development Any process that stops, prevents or reduces the frequency, rate or extent of muscle development. BP
GO:0048634 regulation of muscle development Any process that modulates the frequency, rate or extent of muscle development. BP
GO:0048637 skeletal muscle development The process whose specific outcome is the progression of the skeletal muscle over time, from its formation to the mature structure. BP
GO:0048636 positive regulation of muscle development Any process that activates, maintains or increases the rate of muscle development. BP
GO:0044245 polysaccharide digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism. BP
GO:0051309 female meiosis chromosome separation The process by which paired chromosomes are physically detached from each other during female meiosis. BP
GO:0051308 male meiosis chromosome separation The process by which paired chromosomes are physically detached from each other during male meiosis. BP
GO:0051307 meiotic chromosome separation The process by which chromosomes are physically detached from each other during meiosis. BP
GO:0051306 mitotic sister chromatid separation The process by which sister chromatids are physically detached from each other during mitosis. BP
GO:0051305 chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes. BP
GO:0051304 chromosome separation The cell cycle process whereby paired chromosomes are detached from each other. In budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. BP
GO:0051303 establishment of chromosome localization The directed movement of a chromosome to a specific location. BP
GO:0051302 regulation of cell division Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. BP
GO:0051301 cell division The processes resulting in the physical partitioning and separation of a cell into daughter cells. BP
GO:0051300 spindle pole body organization and biogenesis The assembly and arrangement of the spindle pole body, the microtubule organizing center in fungi; it is functionally homologous to the animal cell centrosome. BP
GO:0007571 age-dependent general metabolic decline The process arising as the cell progresses toward the end of its lifespan that cause changes cellular metabolism, resulting in a decline in cell function; for example, a decline in the efficiency of protein synthesis. BP
GO:0015219 DNA-protein complex transporter activity Enables the directed movement of DNA-protein complexes into, out of, within or between cells. MF
GO:0015218 pyrimidine nucleotide transporter activity Enables the directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. MF
GO:0015215 nucleotide transporter activity Enables the directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. MF
GO:0015214 pyrimidine nucleoside transporter activity Enables the directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells. MF
GO:0015217 ADP transporter activity Enables the directed movement of ADP, adenosine diphosphate, into, out of, within or between cells. MF
GO:0015216 purine nucleotide transporter activity Enables the directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. MF
GO:0015211 purine nucleoside transporter activity Enables the directed movement of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells. MF
GO:0015210 uracil transporter activity Enables the directed movement of uracil, 2,4-dioxopyrimidine, into, out of, within or between cells. MF
GO:0015213 uridine transporter activity Enables the directed movement of uridine, uracil riboside, into, out of, within or between cells. MF
GO:0015212 cytidine transporter activity Enables the directed movement of cytidine, cytosine riboside, into, out of, within or between cells. MF
GO:0019743 hopanoid catabolic process The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. BP
GO:0019742 pentacyclic triterpenoid metabolic process The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. BP
GO:0019741 pentacyclic triterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. BP
GO:0019740 nitrogen utilization NA BP
GO:0019747 regulation of isoprenoid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids. BP
GO:0019746 hopanoid biosynthetic process The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. BP
GO:0019745 pentacyclic triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings. BP
GO:0019744 hopanoid metabolic process The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. BP
GO:0019749 cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte. BP
GO:0019748 secondary metabolic process The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. BP
GO:0030728 ovulation The release of a mature ovum/oocyte from an ovary. BP
GO:0030729 acetoacetate-CoA ligase activity Catalysis of the reaction: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA. MF
GO:0001838 embryonic epithelial tube formation The morphogenesis of an embryonic epithelium into a tube-shaped structure. BP
GO:0001839 neural plate morphogenesis The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. BP
GO:0001830 trophectodermal cell fate commitment The cell fate commitment of precursor cells that will become trophectoderm cells. BP
GO:0001831 trophectodermal cellular morphogenesis The morphogenesis of trophectoderm cells. BP
GO:0001832 blastocyst growth An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. BP
GO:0001833 inner cell mass cell proliferation The proliferation of cells in the inner cell mass. BP
GO:0001834 trophectodermal cell proliferation The proliferation of cells in the trophectoderm. BP
GO:0001835 blastocyst hatching The hatching of the cellular blastocyst from the zona pellucida. BP
GO:0001836 release of cytochrome c from mitochondria The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. BP
GO:0001837 epithelial to mesenchymal transition A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. BP
GO:0030724 testicular fusome organization and biogenesis The assembly and arrangement of the fusome of testicular cells, an organelle derived from the spectrosome. BP
GO:0030725 ring canal formation Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts. BP
GO:0016742 hydroxymethyl-, formyl- and related transferase activity NA MF
GO:0016743 carboxyl- and carbamoyltransferase activity NA MF
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. MF
GO:0016741 transferase activity, transferring one-carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). MF
GO:0016746 transferase activity, transferring acyl groups Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). MF
GO:0016747 transferase activity, transferring groups other than amino-acyl groups Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). MF
GO:0016744 transferase activity, transferring aldehyde or ketonic groups Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). MF
GO:0021699 cerebellar cortex maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. BP
GO:0021696 cerebellar cortex morphogenesis The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. BP
GO:0021697 cerebellar cortex formation The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. BP
GO:0021694 cerebellar Purkinje cell layer formation The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. BP
GO:0021695 cerebellar cortex development The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. BP
GO:0021692 cerebellar Purkinje cell layer morphogenesis The process by which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. Morphogenesis pertains to the creation of form. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. BP
GO:0021693 cerebellar Purkinje cell layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. BP
GO:0021690 cerebellar molecular layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. BP
GO:0021691 cerebellar Purkinje cell layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. BP
GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate. MF
GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate. MF
GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + organic acid. MF
GO:0016290 palmitoyl-CoA hydrolase activity Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. MF
GO:0016291 acyl-CoA thioesterase activity Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA. MF
GO:0016292 acyl-CoA thioesterase I activity NA MF
GO:0016298 lipase activity Catalysis of the hydrolysis of a lipid or phospholipid. MF
GO:0016299 regulator of G-protein signaling activity Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form. MF
GO:0017165 dipeptidase E activity Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides. MF
GO:0017166 vinculin binding Interacting selectively with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. MF
GO:0017161 inositol-1,3,4-trisphosphate 4-phosphatase activity Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate. MF
GO:0017160 Ral GTPase binding Interacting selectively with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. MF
GO:0017163 negative regulator of basal transcription activity NA MF
GO:0017162 aryl hydrocarbon receptor binding Interacting selectively with an aryl hydrocarbon receptor. MF
GO:0017169 CDP-alcohol phosphatidyltransferase activity Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. MF
GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity Catalysis of the reaction: ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate. MF
GO:0031008 filamin-C binding Interacting selectively with filamin-C, a filamin isoform that contains an 81 amino acid insertion in repeat 20, not present in filamin-A or -B. MF
GO:0031009 plastid ADPG pyrophosphorylase complex An ADPG pyrophosphorylase complex found in a plastid. CC
GO:0031006 filamin-A binding Interacting selectively with filamin-A. MF
GO:0031007 filamin-B binding Interacting selectively with filamin-B. MF
GO:0031004 potassium ion-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex. CC
GO:0031005 filamin binding Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. MF
GO:0031002 actin rod A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum. CC
GO:0031003 actin tubule A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together. CC
GO:0031000 response to caffeine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. BP
GO:0031001 response to brefeldin A A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus. BP
GO:0015985 energy coupled proton transport, down electrochemical gradient NA BP
GO:0015987 GTP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis. BP
GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. BP
GO:0015980 energy derivation by oxidation of organic compounds NA BP
GO:0015989 light-driven proton transport NA BP
GO:0015988 energy coupled proton transport, against electrochemical gradient NA BP
GO:0051688 maintenance of plastid localization The processes by which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051689 organismal oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level. BP
GO:0051682 galactomannan catabolic process The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units. BP
GO:0051683 establishment of Golgi localization The directed movement of the Golgi to a specific location. BP
GO:0051680 6-alpha-maltosylglucose biosynthetic process The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose. BP
GO:0051681 6-alpha-maltosylglucose catabolic process The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose. BP
GO:0051686 establishment of ER localization The directed movement of the endoplasmic reticulum to a specific location. BP
GO:0051687 maintenance of spindle localization The processes by which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051684 maintenance of Golgi localization The processes by which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0051685 maintenance of ER localization The processes by which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere. BP
GO:0009254 peptidoglycan turnover The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall. BP
GO:0009255 Entner-Doudoroff pathway A pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. BP
GO:0009256 10-formyltetrahydrofolate metabolic process The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. BP
GO:0009257 10-formyltetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. BP
GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. BP
GO:0009251 glucan catabolic process The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. BP
GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. BP
GO:0009253 peptidoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. BP
GO:0009258 10-formyltetrahydrofolate catabolic process The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate. BP
GO:0009259 ribonucleotide metabolic process The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. BP
GO:0016664 oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein. MF
GO:0044399 multi-species biofilm formation A process whereby microorganisms of different species attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. BP
GO:0000178 exosome (RNase complex) Complex of 3'-5' exoribonucleases. CC
GO:0016669 oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome. MF
GO:0016668 oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. MF
GO:0046897 N-terminal peptidyl-tyrosine methylation The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine. BP
GO:0046896 N-terminal peptidyl-leucine methylation The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine. BP
GO:0046895 N-terminal peptidyl-isoleucine methylation The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine. BP
GO:0046894 enzyme active site formation via S-amidino-L-cysteine The transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine. BP
GO:0046893 iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase. BP
GO:0046892 peptidyl-S-carbamoyl-L-cysteine dehydration The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine. BP
GO:0046891 peptidyl-cysteine S-carbamoylation The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine. BP
GO:0046890 regulation of lipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. BP
GO:0046899 nucleoside triphosphate adenylate kinase activity Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. MF
GO:0046898 response to cycloheximide A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. BP
GO:0043629 ncRNA polyadenylation The enzymatic addition of a sequence of adenylyl residues (typically 15-70 in S. cerevisiae) at the 3' end of substrates that may include the following nuclear non-coding RNAs (ncRNA) from eukaryotes: nuclear ncRNA precursors (includes pre-RNA, snoRNA and snRNA that may be incorrectly processed and/or assembled with proteins), aberrant nuclear ncRNAs (such as hypomethylated tRNA and short 5S rRNA), misfolded nuclear ncRNAs and variant forms of ncRNAs. Serves as a prerequisite step for subsequent exosome-mediated degradation. BP
GO:0043628 ncRNA 3'-end processing Any process involved in forming the mature 3' end of a non-coding RNA molecule. BP
GO:0043627 response to estrogen stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. BP
GO:0008616 queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. BP
GO:0008615 pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. BP
GO:0043624 cellular protein complex disassembly The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. BP
GO:0043623 cellular protein complex assembly The aggregation and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. BP
GO:0008612 hypusine biosynthetic process from peptidyl-lysine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. BP
GO:0008611 ether lipid biosynthetic process The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one fatty alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. BP
GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. BP
GO:0045272 respiratory chain complex I (sensu Bacteria) A part of the respiratory chain, containing about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron; the iron undergoes oxidation-reduction between Fe(II) and Fe(III). Catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045273 respiratory chain complex II A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. CC
GO:0045270 proton-transporting ATP synthase, central stalk (sensu Bacteria) One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis. As in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045271 respiratory chain complex I Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. It is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. CC
GO:0045276 respiratory chain complex III (sensu Bacteria) A part of the respiratory chain, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045277 respiratory chain complex IV A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). CC
GO:0045274 respiratory chain complex II (sensu Bacteria) A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045275 respiratory chain complex III A part of the respiratory chain, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. CC
GO:0045278 respiratory chain complex IV (sensu Bacteria) A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0045279 NADH dehydrogenase complex (ubiquinone) Complex that possesses NADH dehydrogenase (ubiquinone) activity. CC
GO:0032728 positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production. BP
GO:0032729 positive regulation of interferon-gamma production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. BP
GO:0032726 positive regulation of hepatocyte growth factor production Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production. BP
GO:0032727 positive regulation of interferon-alpha production Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. BP
GO:0032724 positive regulation of fractalkine production Any process that activates or increases the frequency, rate, or extent of fractalkine production. BP
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. BP
GO:0032722 positive regulation of chemokine production Any process that activates or increases the frequency, rate, or extent of chemokine production. BP
GO:0032723 positive regulation of connective tissue growth factor production Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production. BP
GO:0032720 negative regulation of tumor necrosis factor-alpha production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor-alpha production. BP
GO:0032721 negative regulation of tumor necrosis factor-beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor-beta production. BP
GO:0015158 raffinose transporter activity Enables the directed movement of raffinose into, out of, within or between cells. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. MF
GO:0015159 polysaccharide transporter activity Enables the directed movement of polysaccharides into, out of, within or between cells. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages. MF
GO:0015152 glucose-6-phosphate transporter activity Enables the directed movement of glucose-6-phosphate into, out of, within or between cells. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. MF
GO:0015153 rhamnose transporter activity Enables the directed movement of rhamnose into, out of, within or between cells. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. MF
GO:0015150 fucose transporter activity Enables the directed movement of fucose into, out of, within or between cells. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. MF
GO:0015151 alpha-glucoside transporter activity Enables the directed movement of alpha-glucosides into, out of, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. MF
GO:0015156 melibiose transporter activity Enables the directed movement of melibiose into, out of, within or between cells. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants. MF
GO:0015157 oligosaccharide transporter activity Enables the directed movement of oligosaccharide into, out of, within or between cells. MF
GO:0015154 disaccharide transporter activity Enables the directed movement of disaccharide into, out of, within or between cells. MF
GO:0015155 lactose transporter activity Enables the directed movement of lactose into, out of, within or between cells. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. MF
GO:0019179 dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate. MF
GO:0046709 IDP catabolic process The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate. BP
GO:0046708 IDP biosynthetic process The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate. BP
GO:0046707 IDP metabolic process The chemical reactions and pathways involving IDP, inosine 5'-diphosphate. BP
GO:0046706 CDP catabolic process The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate. BP
GO:0046705 CDP biosynthetic process The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate. BP
GO:0046704 CDP metabolic process The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate. BP
GO:0046703 natural killer cell lectin-like receptor binding Interacting selectively with a lectin-like natural killer cell receptor. MF
GO:0046702 galactoside 6-L-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside. MF
GO:0046701 insecticide catabolic process The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects. BP
GO:0046700 heterocycle catabolic process The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). BP
GO:0002619 regulation of non-professional antigen presenting cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation. BP
GO:0002618 positive regulation of macrophage antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. BP
GO:0002615 positive regulation of monocyte antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. BP
GO:0002614 negative regulation of monocyte antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. BP
GO:0002617 negative regulation of macrophage antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. BP
GO:0002616 regulation of macrophage antigen processing and presentation Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. BP
GO:0002611 negative regulation of plasmacytoid dendritic cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. BP
GO:0002610 regulation of plasmacytoid dendritic cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. BP
GO:0002613 regulation of monocyte antigen processing and presentation Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. BP
GO:0002612 positive regulation of plasmacytoid dendritic cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation. BP
GO:0019175 alpha-ribazole-5'-P phosphatase activity Catalysis of the reaction: alpha-ribazole-5'-phosphate = alpha-ribazole + phosphate. MF
GO:0030016 myofibril The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. CC
GO:0030017 sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. CC
GO:0030014 CCR4-NOT complex A large multimeric transcription factor complex that can regulate transcription positively or negatively; consists of a core complex plus additional proteins; may interact with other proteins to control initiation of transcription. In Saccharomyces the core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p; Caf4p, Caf16p, and several less well characterized proteins. CC
GO:0030015 CCR4-NOT core complex The core of the CCR4-NOT transcription factor complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p. CC
GO:0035020 regulation of Rac protein signal transduction Any process that modulates the frequency, rate or extent of Rac protein signal transduction. BP
GO:0035021 negative regulation of Rac protein signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of Rac protein signal transduction. BP
GO:0030010 establishment of cell polarity The specification and formation of anisotropic intracellular organization or cell growth patterns. BP
GO:0030011 maintenance of cell polarity The maintenance of established anisotropic intracellular organization or cell growth patterns. BP
GO:0035028 leading edge cell fate determination Process by which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. BP
GO:0035029 dorsal closure, leading edge cell fate commitment The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis. BP
GO:0030018 Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. CC
GO:0030019 tryptase activity Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin. MF
GO:0043368 positive T cell selection The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. BP
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. BP
GO:0043362 nucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. BP
GO:0043363 nucleate erythrocyte differentiation The process by which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. BP
GO:0043360 glial cell differentiation (sensu Nematoda and Protostomia) The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043361 glial cell fate determination (sensu Nematoda and Protostomia) Process by which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed. As in, but not restricted to, the roundworms (Nematoda, ncbi_taxonomy_id:6231) and the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317). BP
GO:0043366 beta selection The signaling from the pre-T cell receptor complex indicative of successful recombination of a T cell receptor beta chain into a translatable protein coding sequence and the resulting processes which lead to the rescue from apoptosis and subsequent proliferation of an immature T cell. BP
GO:0043367 CD4-positive, alpha beta T cell differentiation The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. BP
GO:0043364 catalysis of free radical formation Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair. MF
GO:0043365 [formate-C-acetyltransferase]-activating enzyme Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical. MF
GO:0004510 tryptophan 5-monooxygenase activity Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. MF
GO:0004511 tyrosine 3-monooxygenase activity Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. MF
GO:0004512 inositol-3-phosphate synthase activity Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. MF
GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide. MF
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0004515 nicotinate-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. MF
GO:0004516 nicotinate phosphoribosyltransferase activity Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. MF
GO:0004517 nitric-oxide synthase activity Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. MF
GO:0004518 nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids. MF
GO:0004519 endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. MF
GO:0009931 calcium-dependent protein serine/threonine kinase activity NA MF
GO:0009930 longitudinal side of cell surface (sensu Magnoliophyta) The side of the cell parallel to the zygotic axis. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0009933 meristem organization Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. BP
GO:0009932 cell tip growth Growth that occurs specifically at the tip of a cell. BP
GO:0009935 nutrient import The directed movement of nutrients into a cell or organelle. BP
GO:0009934 regulation of meristem organization Any process that modulates the frequency, rate or extent of meristem organization. BP
GO:0009937 regulation of gibberellic acid mediated signaling Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling. BP
GO:0009939 positive regulation of gibberellic acid mediated signaling Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity. BP
GO:0009938 negative regulation of gibberellic acid mediated signaling Any process that stops, prevents or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity. BP
GO:0042709 succinate-CoA ligase complex A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP. CC
GO:0042708 elastase activity Catalysis of the hydrolysis of elastin. MF
GO:0042703 menstruation The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus. BP
GO:0042702 uterine wall growth The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels. BP
GO:0042701 progesterone secretion The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta. BP
GO:0042700 luteinizing hormone signaling pathway The series of molecular signals mediated by luteinizing hormone. BP
GO:0042707 non-eye photoreceptor cell fate commitment The process by which a cell becomes committed to become an non-eye photoreceptor cell. BP
GO:0042706 eye photoreceptor cell fate commitment The process by which a cell becomes committed to become an eye photoreceptor cell. BP
GO:0042705 non-eye photoreceptor cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a photoreceptor cell found outside of the eye. BP
GO:0042704 uterine wall breakdown The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels. BP
GO:0050489 ecdysteroid UDP-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + ecdysteroid = UDP + glucuronosyl-ecdysteroid. MF
GO:0050488 ecdysteroid UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid. MF
GO:0050487 sulfoacetaldehyde acetyltransferase activity Catalysis of the reaction: SO3(2-) (sulfite) + acetyl phosphate = 2-sulfoacetaldehyde + phosphate. MF
GO:0050486 intramolecular transferase activity, transferring hydroxy groups Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule. MF
GO:0050485 oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide. MF
GO:0050484 GMP 5'-nucleotidase activity Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate. MF
GO:0050483 IMP 5'-nucleotidase activity Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate. MF
GO:0050482 arachidonic acid secretion The regulated release of arachidonic acid from a cell or group of cells. BP
GO:0050481 mandelate 4-monooxygenase activity Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + O2 + (tetrahydrobiopterin/tetrahydropteridine) = (S)-4-hydroxymandelate + H2O + (dihydrobiopterin/dihydropteridine). (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate. MF
GO:0050480 imidazolonepropionase activity Catalysis of the reaction: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = H+ + N-formimidoyl-L-glutamate. MF
GO:0007554 regulation of ecdysteroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. BP
GO:0003988 acetyl-CoA C-acyltransferase activity Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. MF
GO:0003989 acetyl-CoA carboxylase activity Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. MF
GO:0003986 acetyl-CoA hydrolase activity Catalysis of the reaction: acetyl-CoA + H2O = CoA + acetate. MF
GO:0003987 acetate-CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. MF
GO:0003984 acetolactate synthase activity Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. MF
GO:0003985 acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. MF
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity Catalysis of the reaction: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. MF
GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. MF
GO:0007557 regulation of juvenile hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone. BP
GO:0007556 regulation of juvenile hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. BP
GO:0042646 plastid nucleoid The region of a plastid to which the DNA is confined. CC
GO:0042647 proplastid nucleoid The region of a proplastid to which the DNA is confined. CC
GO:0042644 chloroplast nucleoid The region of a chloroplast to which the DNA is confined. CC
GO:0042645 mitochondrial nucleoid The region of a mitochondrion to which the DNA is confined. CC
GO:0031226 intrinsic to plasma membrane Located in the plasma membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product spans or is embedded in one or both leaflets of the membrane. CC
GO:0019239 deaminase activity Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). MF
GO:0019238 cyclohydrolase activity NA MF
GO:0042640 anagen The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair. BP
GO:0019233 sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. BP
GO:0019232 perception of rate of movement The series of events by which an organism senses the speed and direction of movement of the body and its parts. BP
GO:0019231 perception of static position The perception of the orientation of different parts of the body with respect to one another. BP
GO:0019230 proprioception The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors. BP
GO:0019237 centromeric DNA binding Interacting selectively with centromere-associated DNA, usually characterized by highly repetitive sequences. MF
GO:0019236 response to pheromone A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. BP
GO:0019235 sensory perception of slow pain The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction. BP
GO:0019234 sensory perception of fast pain The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds. BP
GO:0052247 positive energy taxis within other organism during symbiotic interaction The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052246 positive energy taxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052245 negative energy taxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052244 negative energy taxis within other organism during symbiotic interaction The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction. BP
GO:0052243 chemotaxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052242 chemotaxis within other organism during symbiotic interaction The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052241 positive chemotaxis on or near other organism during symbiotic interaction The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052240 positive chemotaxis within other organism during symbiotic interaction The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052249 modulation of RNA levels in other organism during symbiotic interaction The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052248 modulation of programmed cell death in other organism during symbiotic interaction Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0000169 activation of MAPK activity during osmolarity sensing Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing. BP
GO:0000168 activation of MAPKK activity during osmolarity sensing Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing. BP
GO:0000161 MAPKKK cascade during osmolarity sensing MAPKKK cascade involved in signal transduction in response to change in osmotic conditions. BP
GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. BP
GO:0000163 protein phosphatase type 1 activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. An ATP, magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa, which is subject to phosphorylation, thus activating the phosphatase. MF
GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. BP
GO:0000165 MAPKKK cascade Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. BP
GO:0000164 protein phosphatase type 1 complex An ATP, magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa, which is subject to phosphorylation, thus activating the phosphatase. CC
GO:0000167 activation of MAPKKK activity during osmolarity sensing Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing. BP
GO:0000166 nucleotide binding Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. MF
GO:0004899 leukemia inhibitory factor receptor beta-protein activity NA MF
GO:0004891 glycine-inhibited chloride channel activity NA MF
GO:0004890 GABA-A receptor activity Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. MF
GO:0004897 ciliary neurotrophic factor receptor activity NA MF
GO:0004896 hematopoietin/interferon-class (D200-domain) cytokine receptor activity NA MF
GO:0043605 amide catabolic process The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. BP
GO:0018623 benzoate 1,2-dioxygenase activity Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+. MF
GO:0018622 4-chlorophenylacetate 3,4-dioxygenase activity Catalysis of the reaction: 4-chlorophenyl acetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+. MF
GO:0018621 4-sulfobenzoate 3,4-dioxygenase activity Catalysis of the reaction: 4-sulfobenzoate + NADH + H+ + O2 = 3,4-dihydroxybenzoate + SO3(2-) (sulfite) + NAD+. MF
GO:0018620 phthalate 4,5-dioxygenase activity Catalysis of the reaction: phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+. MF
GO:0018627 2-aminobenzenesulfonate 2,3-dioxygenase activity Catalysis of the reaction: 2-aminobenzenesulfonate + NADH + H+ + O2 = 2,3-dihydroxybenzenesulfonate + NH3 + NAD+. MF
GO:0018626 2-chlorobenzoate 1,2-dioxygenase activity Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2. MF
GO:0018625 naphthalene 1,2-dioxygenase activity Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+. MF
GO:0018624 toluene dioxygenase activity Catalysis of the reaction: toluene + NADH + H+ + O2 = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+. MF
GO:0018629 2-hydroxyquinoline 5,6-dioxygenase activity Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+. MF
GO:0018628 terephthalate 1,2-dioxygenase activity Catalysis of the reaction: terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+. MF
GO:0019655 glucose catabolic process to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose. BP
GO:0015398 high affinity ammonium transporter activity NA MF
GO:0015399 primary active transporter activity Catalysis of transport of a solute against a concentration gradient using a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. MF
GO:0015390 purine-specific nucleoside:sodium symporter activity Catalysis of the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in). MF
GO:0015391 nucleobase:cation symporter activity Catalysis of the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in). MF
GO:0015392 cytosine-purine permease activity NA MF
GO:0015394 nucleoside (uridine) permease activity NA MF
GO:0015395 nucleoside transporter activity, down a concentration gradient Enables the directed movement of a nucleoside down the concentration gradient across cell membranes. MF
GO:0015396 equilibrative nucleoside transporter, nitrobenzyl-thioinosine-sensitive activity NA MF
GO:0015397 equilibrative nucleoside transporter, nitrobenzyl-thioinosine-insensitive activity NA MF
GO:0019654 acetate fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP. BP
GO:0005779 integral to peroxisomal membrane Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. CC
GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. CC
GO:0043600 replisome (sensu Bacteria and Archaea) A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2) and the taxon Archaea (Archaea, ncbi_taxonomy_id:2157). CC
GO:0051538 3 iron, 4 sulfur cluster binding Interacting selectively with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing. MF
GO:0051539 4 iron, 4 sulfur cluster binding Interacting selectively with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. MF
GO:0051534 negative regulation of NFAT protein import into nucleus Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. BP
GO:0051535 syntaxin-5 binding Interacting selectively with the SNAP receptor syntaxin-5. MF
GO:0051536 iron-sulfur cluster binding Interacting selectively with an iron-sulfur cluster, a combination of iron and sulfur ions. MF
GO:0051537 2 iron, 2 sulfur cluster binding Interacting selectively with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. MF
GO:0051530 NFAT5 protein binding Interacting selectively with NFAT1 (nuclear factor of activated T cells 1 protein), a member of the NFAT transcription factor family which is not calcium regulated. MF
GO:0051531 NFAT protein import into nucleus The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane. BP
GO:0051532 regulation of NFAT protein import into nucleus Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. BP
GO:0051533 positive regulation of NFAT protein import into nucleus Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. BP
GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. CC
GO:0005771 multivesicular body A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. CC
GO:0016153 urocanate hydratase activity Catalysis of the reaction: 4,5-dihydro-4-oxo-5-imidazolepropanoate = urocanate + H2O. MF
GO:0016152 mercury (II) reductase activity Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+. MF
GO:0016151 nickel ion binding Interacting selectively with nickel (Ni) ions. MF
GO:0016150 translation release factor activity, codon nonspecific A translation release factor that is not specific to particular codons; binds to guanine nucleotides. MF
GO:0016157 sucrose synthase activity Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. MF
GO:0016156 fumarate reductase (NADH) activity Catalysis of the reaction: succinate + NAD+ = fumarate + NADH + H+. MF
GO:0016155 formyltetrahydrofolate dehydrogenase activity Catalysis of the reaction: 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+. MF
GO:0016154 pyrimidine-nucleoside phosphorylase activity Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. MF
GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). CC
GO:0016159 muconolactone delta-isomerase activity Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate. MF
GO:0016158 3-phytase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. MF
GO:0005776 autophagic vacuole A double-membrane bound vesicle in which endogenous cellular material is sequestered; known as autophagosome in yeast. CC
GO:0005775 vacuolar lumen The volume enclosed within the vacuolar membrane. CC
GO:0005774 vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. CC
GO:0046277 methylgallate biosynthetic process The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. BP
GO:0046276 methylgallate catabolic process The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid. BP
GO:0046275 flavonoid catabolic process The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton. BP
GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. BP
GO:0046273 lignan catabolic process The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist. BP
GO:0046272 stilbene catabolic process The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA. BP
GO:0046271 phenylpropanoid catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid. BP
GO:0046279 protocatechuate biosynthetic process The chemical reactions and pathways resulting in the formation of protocatechuate, the anion of 3,4-dihydroxybenzoic acid. BP
GO:0046278 protocatechuate metabolic process The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid). BP
GO:0030254 protein secretion by the type III secretion system The process by which proteins are transferred into the extracellular milieu or directly into host cells by the type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. BP
GO:0030255 protein secretion by the type IV secretion system The process by which nucleoprotein DNA conjugation intermediates or proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system. BP
GO:0030256 type I protein secretion system complex A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space. CC
GO:0030257 type III protein secretion system complex A complex of approximately 20 proteins, most of which are located in the inner membrane that carries out protein secretion in the type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. CC
GO:0030250 guanylate cyclase activator activity Increases the activity of guanylate cyclase. MF
GO:0030251 guanylate cyclase inhibitor activity Stops, prevents or reduces the activity of guanylate cyclase. MF
GO:0030252 growth hormone secretion The regulated release of growth hormone from secretory granules into the blood. BP
GO:0030253 protein secretion by the type I secretion system The process by which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. BP
GO:0030258 lipid modification The covalent alteration of one or more fatty acids in a lipid, resulting in a change in that lipid. BP
GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. BP
GO:0031619 homologous chromosome orientation during meiosis The cell cycle process whereby the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I. BP
GO:0031618 nuclear centric heterochromatin Chromatin located near the centromere of a chromosome in the nucleus. CC
GO:0031617 NMS complex A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in SchizoSaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes. CC
GO:0031616 spindle pole centrosome A centrosome from which one pole of a mitotic or meiotic spindle is organized. CC
GO:0031615 cytosolic proteasome regulatory particle, lid subcomplex (sensu Eukaryota) The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0031614 ER proteasome regulatory particle, lid subcomplex The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell. CC
GO:0031613 nuclear proteasome regulatory particle, lid subcomplex The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell. CC
GO:0031612 cytosolic proteasome regulatory particle, base subcomplex (sensu Eukaryota) The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the cytosol of a cell; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0031611 ER proteasome regulatory particle, base subcomplex The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell. CC
GO:0031610 nuclear proteasome regulatory particle, base subcomplex The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell. CC
GO:0030260 entry into host cell The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0002839 positive regulation of immune response to tumor cell Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. BP
GO:0002838 negative regulation of immune response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell. BP
GO:0002835 negative regulation of response to tumor cell Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell. BP
GO:0002834 regulation of response to tumor cell Any process that modulates the frequency, rate, or extent of a response to tumor cell. BP
GO:0002837 regulation of immune response to tumor cell Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. BP
GO:0002836 positive regulation of response to tumor cell Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. BP
GO:0002831 regulation of response to biotic stimulus Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. BP
GO:0002830 positive regulation of T-helper 2 type immune response Any process that activates or increases the frequency, rate, or extent of a T-helper 2 type immune response. BP
GO:0002833 positive regulation of response to biotic stimulus Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. BP
GO:0002832 negative regulation of response to biotic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. BP
GO:0009779 noncyclic photosynthetic phosphorylation ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II. BP
GO:0009778 cyclic photosynthetic phosphorylation ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I. BP
GO:0009777 photosynthetic phosphorylation The metabolic processes by which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation. BP
GO:0009776 photosynthetic electron transport in plastocyanin NA BP
GO:0009775 photosynthetic electron transport in cytochrome b6/f NA BP
GO:0009774 photosynthetic electron transport in plastoquinone NA BP
GO:0009773 photosynthetic electron transport in photosystem I Electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP. BP
GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. BP
GO:0009771 primary charge separation in photosystem II Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side. BP
GO:0009770 primary charge separation in photosystem I Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side. BP
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. MF
GO:0046910 pectinesterase inhibitor activity Stops, prevents or reduces the activity of any pectinesterase enzyme. MF
GO:0046911 metal chelating activity The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring. MF
GO:0046916 transition metal ion homeostasis The regulation of the levels, transport, and metabolism of transition metal ions within a cell or between a cell and its external environment. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. BP
GO:0046917 triphosphoribosyl-dephospho-CoA synthase activity Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. MF
GO:0046914 transition metal ion binding Interacting selectively with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. MF
GO:0046915 transition metal ion transporter activity Enables the directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. MF
GO:0046918 N-terminal peptidyl-glycine N-palmitoylation The palmitoylation of the N-terminal glycine of proteins to form the derivative N-palmitoyl-glycine. BP
GO:0046919 pyruvyltransferase activity Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another. MF
GO:0008798 beta-aspartyl-peptidase activity Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide. MF
GO:0008792 arginine decarboxylase activity Catalysis of the reaction: L-arginine = agmatine + CO2. MF
GO:0008793 aromatic-amino-acid transaminase activity Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate. MF
GO:0008790 arabinose isomerase activity Catalysis of the reaction: D-arabinose = D-ribulose. MF
GO:0008791 arginine N-succinyltransferase activity Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine. MF
GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. MF
GO:0008797 aspartate ammonia-lyase activity Catalysis of the reaction: L-aspartate = fumarate + NH3. MF
GO:0008794 arsenate reductase (glutaredoxin) activity Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. MF
GO:0008795 NAD+ synthase activity Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. MF
GO:0008428 ribonuclease inhibitor activity Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA. MF
GO:0008429 phosphatidylethanolamine binding Interacting selectively with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. MF
GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine. MF
GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. MF
GO:0008426 protein kinase C inhibitor activity Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. MF
GO:0008427 calcium-dependent protein kinase inhibitor activity Stops, prevents or reduces the activity of a calcium-dependent protein kinase. MF
GO:0008420 CTD phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. MF
GO:0008421 long-chain-fatty-acyl-glutamate deacylase activity Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate. MF
GO:0008422 beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. MF
GO:0008423 bleomycin hydrolase activity Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred. MF
GO:0042169 SH2 domain binding Interacting selectively with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. MF
GO:0042168 heme metabolic process The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. BP
GO:0042163 interleukin-12 beta subunit binding Interacting selectively with the beta subunit of interleukin-12. MF
GO:0042162 telomeric DNA binding Interacting selectively with telomere-associated DNA, usually characterized by highly repetitive sequences. MF
GO:0042161 lipoprotein oxidation NA BP
GO:0042160 lipoprotein modification The enzymatic modification of a lipoprotein; any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. BP
GO:0042167 heme catabolic process The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. BP
GO:0042166 acetylcholine binding Interacting selectively with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. MF
GO:0042165 neurotransmitter binding Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. MF
GO:0042164 interleukin-12 alpha subunit binding Interacting selectively with the alpha subunit of interleukin-12. MF
GO:0045755 negative regulation of initiation of acetate catabolic process by acetate Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. BP
GO:0045754 positive regulation of acetate catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. BP
GO:0045756 positive regulation of initiation of acetate catabolic process by acetate Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. BP
GO:0045751 negative regulation of Toll signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the Tl signaling pathway. BP
GO:0045750 positive regulation of S phase of mitotic cell cycle Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity. BP
GO:0045753 negative regulation of acetate catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. BP
GO:0045752 positive regulation of Toll signaling pathway Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway. BP
GO:0045759 negative regulation of action potential Any process that stops, prevents or reduces the frequency, rate or extent of action potential creation, propagation or termination. BP
GO:0042299 lupeol synthase activity Catalysis of the cyclization of (S)-2,3-oxidosqualene to lupeol. MF
GO:0047669 amylosucrase activity Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1). MF
GO:0047668 amygdalin beta-glucosidase activity Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose. MF
GO:0047667 AMP-thymidine kinase activity Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate. MF
GO:0042294 URM1 conjugating enzyme activity Catalysis of the covalent attachment of the ubiquitin-like protein URM1 to other proteins or other substrate molecules. MF
GO:0042297 vocal learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an auditory cue. BP
GO:0042296 ISG15 conjugating enzyme activity Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins. MF
GO:0047663 aminoglycoside N6'-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + kanamycin-B = CoA + N6'-acetylkanamycin-B. MF
GO:0047662 aminobenzoate decarboxylase activity Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2. MF
GO:0042293 Hub1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0042292 URM1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond. MF
GO:0030931 ADPG pyrophosphorylase complex (sensu Eukaryota) A heterotetrameric that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759). CC
GO:0030930 ADPG pyrophosphorylase complex (sensu Bacteria) A homotetrameric that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2). CC
GO:0030933 chloroplast ADPG pyrophosphorylase complex An ADPG pyrophosphorylase complex found in the chloroplast. CC
GO:0030932 amyloplast ADPG pyrophosphorylase complex An ADPG pyrophosphorylase complex found in the amyloplast. CC
GO:0030935 sheet-forming collagen Any collagen polymer in which collagen triple helices associate to form sheet-like networks. CC
GO:0030934 anchoring collagen Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures. CC
GO:0030937 collagen type XVII A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina. CC
GO:0030936 transmembrane collagen Any collagen polymer that passes through a lipid bilayer membrane. CC
GO:0030938 collagen type XVIII A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures. CC
GO:0050911 detection of chemical stimulus during sensory perception of smell The series of events during the perception of smell in which an olfactory chemical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050910 detection of mechanical stimulus during sensory perception of sound The series of events during the perception of sound in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. Sound is picked up in the form of vibrations. BP
GO:0050913 sensory perception of bitter taste The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0050912 detection of chemical stimulus during sensory perception of taste The series of events during the perception of taste in which a gustatory chemical stimulus is received by a cell and converted into a molecular signal. BP
GO:0050915 sensory perception of sour taste The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0050914 sensory perception of salty taste The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0050917 sensory perception of umami taste The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. BP
GO:0050916 sensory perception of sweet taste The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. BP
GO:0050919 negative chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a lower concentration, in a concentration gradient of a specific chemical. BP
GO:0050918 positive chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a higher concentration, in a concentration gradient of a specific chemical. BP
GO:0002798 negative regulation of antibacterial peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion. BP
GO:0002799 positive regulation of antibacterial peptide secretion Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion. BP
GO:0002790 peptide secretion The regulated release of a peptide from a cell or group of cells. BP
GO:0002791 regulation of peptide secretion Any process that modulates the frequency, rate, or extent of peptide secretion. BP
GO:0002792 negative regulation of peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. BP
GO:0002793 positive regulation of peptide secretion Any process that activates or increases the frequency, rate, or extent of peptide secretion. BP
GO:0002794 regulation of antimicrobial peptide secretion Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion. BP
GO:0002795 negative regulation of antimicrobial peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion. BP
GO:0002796 positive regulation of antimicrobial peptide secretion Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion. BP
GO:0002797 regulation of antibacterial peptide secretion Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion. BP
GO:0044408 growth or development of symbiont on or near host surface The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044409 entry into host Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044402 competition with another organism Any process by which an organism within a multispecies research community gains an advantage in growth or survival over another organism of a different species in that research community. BP
GO:0044403 symbiosis, encompassing mutualism through parasitism An interaction between two organisms living together in more or less intimate association. The term host is usually used for the larger (macro) of the two members of a symbiosis. The smaller (micro) member is called the symbiont organism. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. BP
GO:0044400 multi-species biofilm formation on inanimate substrate A process whereby microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. BP
GO:0044401 multi-species biofilm formation in or on host organism A process whereby microorganisms of different species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044406 adhesion to host The attachment of an organism to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044407 single-species biofilm formation in or on host organism A process whereby microorganisms of the same species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0044405 recognition of host The specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0046134 pyrimidine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0046135 pyrimidine nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). BP
GO:0046136 positive regulation of vitamin metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. BP
GO:0046137 negative regulation of vitamin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. BP
GO:0046130 purine ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0046131 pyrimidine ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0046132 pyrimidine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0046133 pyrimidine ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. BP
GO:0035183 ring canal inner rim A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins. CC
GO:0035182 ring canal outer rim An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues. CC
GO:0035181 larval burrowing behavior Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation. BP
GO:0035180 larval wandering behavior The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction. BP
GO:0035187 hatching behavior The specific actions or reactions of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell. BP
GO:0035186 syncytial blastoderm mitotic cell cycle Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively. BP
GO:0048866 stem cell fate specification The process whereby a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. BP
GO:0035184 histone threonine kinase activity Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. MF
GO:0005078 MAP-kinase scaffold activity Functions as a scaffold for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins. MF
GO:0048869 cellular developmental process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. BP
GO:0035189 Rb-E2F complex A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression. CC
GO:0035188 hatching The emergence of an organism from a protective structure. BP
GO:0048807 female genitalia morphogenesis The process by which the anatomical structures of female genitalia are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048248 CXCR3 chemokine receptor binding Interacting selectively with a the CXCR3 chemokine receptor. MF
GO:0048249 high affinity phosphate transporter activity Transporter that catalyzes phosphate transport with a high affinity for phosphate. MF
GO:0048244 phytanoyl-CoA dioxygenase activity Catalysis of the reaction: phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2. MF
GO:0048245 eosinophil chemotaxis The movement of an eosinophil in response to an external stimulus. BP
GO:0048246 macrophage chemotaxis The movement of a macrophage in response to an external stimulus. BP
GO:0048247 lymphocyte chemotaxis The directed movement of a lymphocyte in response to an external stimulus. BP
GO:0048240 sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. BP
GO:0048241 epinephrine transport The directed movement of epinephrine into, out of, within or between cells. BP
GO:0048242 epinephrine secretion The regulated release of epinephrine by a cell or group of cells. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system. BP
GO:0048243 norepinephrine secretion The regulated release of norepinephrine by a cell or group of cells. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. BP
GO:0004301 epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol. MF
GO:0004300 enoyl-CoA hydratase activity Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. MF
GO:0004303 estradiol 17-beta-dehydrogenase activity Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. MF
GO:0004305 ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + O-phosphoethanolamine. MF
GO:0004304 estrone sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. MF
GO:0004307 ethanolaminephosphotransferase activity Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. MF
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. MF
GO:0004309 exopolyphosphatase activity Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. MF
GO:0004308 exo-alpha-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. MF
GO:0052427 modification by host of symbiont protease activity The process by which an organism effects a change in symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0018420 peptide cross-linking via N6-(L-isoaspartyl)-L-lysine The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues. BP
GO:0018423 protein-leucine O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester; this reaction is the methylation of peptidyl-L-leucine to form peptidyl-L-leucine methyl ester. MF
GO:0018422 GDP-mannose:serine-protein mannose-1-phosphotransferase activity NA MF
GO:0052423 positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0052422 modification by host of symbiont enzyme activity The process by which an organism effects a change in symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0018427 copper incorporation into metallo-sulfur cluster The incorporation of copper into a metallo-sulfur cluster. BP
GO:0052420 metabolism by host of symbiont xylan The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. BP
GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells. BP
GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells. BP
GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells. BP
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. BP
GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells. BP
GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells. BP
GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells. BP
GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate. MF
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. MF
GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2. MF
GO:0003826 alpha-ketoacid dehydrogenase activity NA MF
GO:0003823 antigen binding Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. MF
GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R. MF
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R. MF
GO:0042938 dipeptide transport The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells. BP
GO:0042939 tripeptide transport The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells. BP
GO:0048809 analia morphogenesis (sensu Endopterygota) The process by which the anatomical structures of analia are generated and organized. Morphogenesis pertains to the creation of form. The analia develops from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0006953 acute-phase response Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. BP
GO:0042930 enterobactin transport The directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of, within or between cells. BP
GO:0042931 enterobactin transporter activity Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of, within or between cells. MF
GO:0042932 chrysobactin transport The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of, within or between cells. BP
GO:0042933 chrysobactin transporter activity Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of, within or between cells. MF
GO:0042934 achromobactin transporter activity Enables the directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells. MF
GO:0042935 achromobactin transport The directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells. BP
GO:0042936 dipeptide transporter activity Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells. MF
GO:0042937 tripeptide transporter activity Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells. MF
GO:0006958 complement activation, classical pathway Processes involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. BP
GO:0006959 humoral immune response An immune response mediated through a body fluid. BP
GO:0050146 nucleoside phosphotransferase activity Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate. MF
GO:0050147 nucleoside ribosyltransferase activity Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1. MF
GO:0050144 nucleoside deoxyribosyltransferase activity Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1. MF
GO:0050145 nucleoside phosphate kinase activity Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate. MF
GO:0050142 nitrogenase (flavodoxin) activity Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate. MF
GO:0050143 nocardicin-A epimerase activity Catalysis of the reaction: isonocardicin A = nocardicin A. MF
GO:0050140 nitrate reductase (cytochrome) activity Catalysis of the reaction: ferrocytochrome + NO3- (nitrate) = ferricytochrome + NO2- (nitrite). MF
GO:0050141 nitroethane oxidase activity Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + NO2(-) (nitrite) + H2O2. MF
GO:0050148 nucleotide diphosphokinase activity Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate. MF
GO:0050149 o-aminophenol oxidase activity Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O. MF
GO:0005892 nicotinic acetylcholine-gated receptor-channel complex NA CC
GO:0005893 interleukin-2 receptor complex Complex that binds interleukin-2; comprises alpha, beta, and gamma subunits. CC
GO:0005890 sodium:potassium-exchanging ATPase complex Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. CC
GO:0005891 voltage-gated calcium channel complex NA CC
GO:0005896 interleukin-6 receptor complex A hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130. CC
GO:0051438 regulation of ubiquitin ligase activity Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. BP
GO:0005894 interleukin-3 receptor complex Complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5. CC
GO:0005895 interleukin-5 receptor complex Complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3. CC
GO:0051435 BH4 domain binding Interacting selectively with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein. MF
GO:0051434 BH3 domain binding Interacting selectively with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. MF
GO:0005898 interleukin-13 receptor complex A complex that binds interleukin-13; consists of two chains, interleukin-4 receptor alpha chain and interleukin-4 receptor alpha chain. CC
GO:0005899 insulin receptor complex A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain. CC
GO:0051431 corticotropin-releasing hormone receptor 2 binding Interacting selectively with the protein corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery. MF
GO:0051430 corticotropin-releasing hormone receptor 1 binding Interacting selectively with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on adrenocorticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. MF
GO:0051433 BH2 domain binding Interacting selectively with the BH2 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. MF
GO:0051432 BH1 domain binding Interacting selectively with the BH1 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. MF
GO:0007021 tubulin folding Folding of the microtubule constituent proteins alpha- and beta-tubulin into the native alpha-beta heterodimer. BP
GO:0007020 microtubule nucleation The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. BP
GO:0007023 post-chaperonin tubulin folding pathway Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors. BP
GO:0007022 chaperonin-mediated tubulin folding Partial folding of alpha- or beta-tubulin into a non-native folding intermediate, mediated by cytosolic chaperonin CCT. BP
GO:0007025 beta-tubulin folding Folding of the microtubule constituent protein beta-tubulin. BP
GO:0007024 alpha-tubulin folding Folding of the microtubule constituent protein alpha-tubulin. BP
GO:0007027 axonemal microtubule stabilization Prevention of depolymerization of the specialized microtubules of the axoneme. BP
GO:0007026 negative regulation of microtubule depolymerization Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. BP
GO:0007029 endoplasmic reticulum organization and biogenesis The assembly and arrangement of the endoplasmic reticulum. BP
GO:0007028 cytoplasm organization and biogenesis The assembly and arrangement of the cytoplasm and its components. BP
GO:0018421 UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity NA MF
GO:0048725 fish trap bristle development The process whose specific outcome is the progression of the fish trap bristle over time, from its formation to the mature structure. BP
GO:0052162 modulation by symbiont of defense-related host calcium ion flux Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052163 modulation by symbiont of defense-related host nitric oxide production Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052160 modulation by symbiont of systemic acquired resistance in host Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052161 modulation by symbiont of defense-related host cell wall thickening Any process by which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052166 positive regulation by symbiont of host innate immunity Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052167 modulation by symbiont of host innate immunity Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052164 modulation by symbiont of defense-related host reactive oxygen species production Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052165 modulation by symbiont of host phytoalexin production Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052168 modulation by symbiont of defense-related host calcium-dependent protein kinase pathway Any process by which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052169 pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity NA BP
GO:0008977 prephenate dehydrogenase activity Catalysis of the reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+. MF
GO:0006048 UDP-N-acetylglucosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0006049 UDP-N-acetylglucosamine catabolic process The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0006040 amino sugar metabolic process The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. BP
GO:0006041 glucosamine metabolic process The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. BP
GO:0006042 glucosamine biosynthetic process The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. BP
GO:0006043 glucosamine catabolic process The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. BP
GO:0006044 N-acetylglucosamine metabolic process The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein. BP
GO:0006045 N-acetylglucosamine biosynthetic process The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein. BP
GO:0006046 N-acetylglucosamine catabolic process The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein. BP
GO:0006047 UDP-N-acetylglucosamine metabolic process The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. BP
GO:0048721 clypeus morphogenesis The process by which the anatomical structures of clypeus are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0005276 hydrogen:vesicular amine antiporter activity NA MF
GO:0042065 glial cell growth Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. BP
GO:0005277 acetylcholine transporter activity Enables the directed movement of acetylcholine into, out of, within or between cells. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. MF
GO:0005274 allantoin permease activity Catalysis of the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in). MF
GO:0048665 neuron fate specification The process whereby a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. BP
GO:0048720 posterior cibarial plate morphogenesis The process by which the anatomical structures of posterior cibarial plate are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0005272 sodium channel activity NA MF
GO:0010278 chloroplast outer membrane translocon The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner. CC
GO:0010279 indole-3-acetic acid amido synthetase Catalysis of the reaction IAA + an amino acid = an IAA amide conjugate. MF
GO:0010274 hydrotropism Growth or movement in a sessile organism toward or away from water, as of the roots of a plant. BP
GO:0010275 NAD(P)H dehydrogenase complex assembly The formation of NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool. BP
GO:0010276 phytol kinase activity Catalysis of the reaction: phytol + CTP = phytylphosphate + CDP. MF
GO:0010277 chlorophyllide a oxygenase activity Catalysis of the reaction: chlorophyllide a + O2 + NADP+ + H+ = chlorophyllide b + H2O + NADPH + H+. MF
GO:0010270 photosystem II oxygen evolving complex assembly Formation of the oxygen evolving complex (OEC) of photosystem II on thylakoid membrane. In plants, the photosystem II OEC consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ; and protects the CaMn4 cluster bound to D1 and CP43 proteins. BP
GO:0010271 regulation of chlorophyll catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll. BP
GO:0010272 response to silver ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus. BP
GO:0010273 detoxification of copper ion The processes that reduce or remove the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion. BP
GO:0042063 gliogenesis The process by which glial cells are generated. This includes the production of glial progenitors and their differentiation into mature glia. BP
GO:0005278 acetylcholine:hydrogen antiporter activity Catalysis of the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out). MF
GO:0048669 collateral sprouting in the absence of injury The process by which outgrowths develop from the axons of intact undamaged neurons. BP
GO:0042060 wound healing The series of events that restore integrity to a damaged tissue, following an injury. BP
GO:0001408 guanine nucleotide transport The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of, within or between cells. BP
GO:0001401 mitochondrial sorting and assembly machinery complex A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex. CC
GO:0001400 mating projection base The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. CC
GO:0001403 invasive growth (sensu Saccharomyces) A growth pattern exhibited by haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930). BP
GO:0001402 signal transduction during filamentous growth Relaying of environmental signals promoting filamentous growth. BP
GO:0001405 presequence translocase-associated import motor Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix. CC
GO:0001407 glycerophosphodiester transport The directed movement of glycerophosphodiesters into, out of, within or between cells. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. BP
GO:0001406 glycerophosphodiester transporter activity Enables the directed movement of glycerophosphodiesters into, out of, within or between cells. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. MF
GO:0005539 glycosaminoglycan binding Interacting selectively with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. MF
GO:0048640 negative regulation of developmental growth Any process that stops, prevents or reduces the frequency, rate or extent of developmental growth. BP
GO:0005534 galactose binding Interacting selectively with galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. MF
GO:0005537 mannose binding Interacting selectively with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. MF
GO:0005536 glucose binding Interacting selectively with the D- and L-enantiomers of glucose. MF
GO:0048642 negative regulation of skeletal muscle development Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle development. BP
GO:0048643 positive regulation of skeletal muscle development Any process that activates, maintains or increases the rate of skeletal muscle development. BP
GO:0048644 muscle morphogenesis The process by which the anatomical structures of muscle are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0015589 mannose permease activity NA MF
GO:0015588 galactitol permease activity NA MF
GO:0015581 maltose porter activity NA MF
GO:0015580 N-acetylglucosamine permease activity NA MF
GO:0015583 beta-glucoside [arbutin-salicin-cellobiose] permease activity Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose. MF
GO:0015582 beta-glucoside permease activity NA MF
GO:0015585 fructose permease activity NA MF
GO:0015584 trehalose permease activity NA MF
GO:0015587 sorbitol permease activity NA MF
GO:0015586 mannitol permease activity NA MF
GO:0018506 maleylacetate reductase activity Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+. MF
GO:0018507 cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity Catalysis of the reaction: (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ = phenanthrene-3,4-diol + NADH + H+. MF
GO:0015633 zinc porter activity Catalysis of the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in). MF
GO:0015632 cobalt porter activity Catalysis of the reaction: ATP + H2O + Co2+(out) = ADP + phosphate + Co2+(in). MF
GO:0015631 tubulin binding Interacting selectively with monomeric or multimeric forms of tubulin, including microtubules. MF
GO:0015630 microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. CC
GO:0047469 4-carboxymethyl-4-methylbutenolide mutase activity Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide. MF
GO:0015636 short-chain fatty acid uptake transporter activity NA MF
GO:0015635 short-chain fatty acid transporter activity Enables the directed movement of short-chain fatty acids into, out of, within or between cells. Short-chain fatty acids have a chain length of less than 8 carbons. MF
GO:0015634 lipopolysaccharide exporter activity NA MF
GO:0047465 N-acylglucosamine-6-phosphate 2-epimerase activity Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. MF
GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. MF
GO:0015639 ferrous iron uptake transporter activity Catalysis of the reaction: Fe2+(out) + energy = Fe2+(in). MF
GO:0015638 microcin uptake permease activity NA MF
GO:0047461 (+)-delta-cadinene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = pyrophosphate + (+)-delta-cadinene. MF
GO:0047460 L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity Catalysis of the reaction: H2O + L-2-amino-4-chloropent-4-enoate = NH3 + HCl + 2-oxopent-4-enoate. MF
GO:0047463 2-aminohexano-6-lactam racemase activity Catalysis of the reaction: L-2-amino-hexano-6-lactam = D-2-amino-hexano-6-lactam. MF
GO:0047462 phenylalanine racemase (ATP-hydrolyzing) activity Catalysis of the reaction: H2O + L-phenylalanine + ATP = D-phenylalanine + pyrophosphate + AMP. MF
GO:0043519 regulation of myosin II filament assembly or disassembly Any process that modulates the frequency, rate or extent of the formation or disassembly of a bipolar filament composed of myosin II molecules. BP
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator Any process that stops, prevents or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. BP
GO:0043515 kinetochore binding Interacting selectively with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. MF
GO:0043514 interleukin-12 complex Secreted heterodimeric cytokine complex composed of an interleukin-12 alpha and an interleukin-12 beta subunit. CC
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. BP
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. BP
GO:0043511 inhibin complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B. CC
GO:0043510 activin B complex A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B). CC
GO:0043513 inhibin B complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit. CC
GO:0043512 inhibin A complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit. CC
GO:0016584 nucleosome spacing Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another. BP
GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. CC
GO:0016586 RSC complex A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. CC
GO:0016587 ISW1 complex A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure. CC
GO:0016580 Sin3 complex A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. CC
GO:0016581 NuRD complex An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in both vertebrates and invertebrates. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. CC
GO:0016582 non-covalent chromatin modification The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups. BP
GO:0016589 NURF complex A four subunit ISWI-containing protein complex that facilitates nucleosome mobility and transcriptional activation in an ATP-dependent manner. In contrast to other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones. CC
GO:0021728 inferior reticular formation development The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure. BP
GO:0021729 superior reticular formation development The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure. BP
GO:0021722 superior olivary nucleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. BP
GO:0021723 rhombencephalic reticular formation development The process whose specific outcome is the progression of the reticular formation over time, from its formation to the mature structure. The reticular formation is a series of brain nuclei located in the medulla oblongata. BP
GO:0021720 superior olivary nucleus formation The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. BP
GO:0021721 superior olivary nucleus structural organization The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. BP
GO:0021726 lateral reticular nucleus development The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure. BP
GO:0021727 intermediate reticular formation development The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure. BP
GO:0021724 inferior raphe nucleus development The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure. BP
GO:0021725 superior raphe nucleus development The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure. BP
GO:0046332 SMAD binding Interacting selectively with a SMAD signaling protein. MF
GO:0046333 octopamine metabolic process The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species. BP
GO:0046330 positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. BP
GO:0046331 lateral inhibition Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells. BP
GO:0046336 ethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). BP
GO:0046337 phosphatidylethanolamine metabolic process The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. BP
GO:0046334 octopamine catabolic process The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species. BP
GO:0046335 ethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). BP
GO:0046338 phosphatidylethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. BP
GO:0046339 diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction. BP
GO:0045827 negative regulation of isoprenoid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid. BP
GO:0045824 negative regulation of innate immune response Any process that stops, prevents or reduces the frequency, rate or extent of the innate immune response. BP
GO:0045823 positive regulation of heart contraction Any process that activates or increases the frequency, rate or extent of heart contraction. BP
GO:0045822 negative regulation of heart contraction Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction. BP
GO:0045821 positive regulation of glycolysis Any process that activates or increases the frequency, rate or extent of glycolysis. BP
GO:0045820 negative regulation of glycolysis Any process that stops, prevents or reduces the frequency, rate or extent of glycolysis. BP
GO:0045829 negative regulation of isotype switching Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching. BP
GO:0045828 positive regulation of isoprenoid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid. BP
GO:0030779 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine. MF
GO:0030778 columbamine O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine. MF
GO:0030777 (S)-scoulerine 9-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine. MF
GO:0030776 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline. MF
GO:0030775 glucuronoxylan 4-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate. MF
GO:0030774 anthranilate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + N-methylanthranilate. MF
GO:0030773 6-hydroxymellein O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 6-hydroxymellein = S-adenosyl-L-homocysteine + 6-methoxymellein. MF
GO:0030772 tryptophan 2-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan. MF
GO:0030771 N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-benzoyl-4-hydroxyanthranilate = S-adenosyl-L-homocysteine + N-benzoyl-4-methoxyanthranilate. MF
GO:0030770 demethylmacrocin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin. MF
GO:0045175 basal protein localization The processes by which a protein is transported to, or maintained in, basal regions of the cell. BP
GO:0045174 glutathione dehydrogenase (ascorbate) activity Catalysis of the reaction: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate. MF
GO:0031798 type 1 metabotropic glutamate receptor binding Interacting selectively with a type 1 metabotropic glutamate receptor. MF
GO:0031799 type 2 metabotropic glutamate receptor binding Interacting selectively with a type 2 metabotropic glutamate receptor. MF
GO:0045171 intercellular bridge A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells. CC
GO:0045170 spectrosome A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome. CC
GO:0045173 O-sialoglycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities. BP
GO:0045172 ring canal (sensu Insecta) Germline specific intercellular bridge, as in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells. CC
GO:0031792 M3 muscarinic acetylcholine receptor binding Interacting selectively with a M3 muscarinic acetylcholine receptor. MF
GO:0031793 M4 muscarinic acetylcholine receptor binding Interacting selectively with a M4 muscarinic acetylcholine receptor. MF
GO:0031790 M1 muscarinic acetylcholine receptor binding Interacting selectively with a M1 muscarinic acetylcholine receptor. MF
GO:0031791 M2 muscarinic acetylcholine receptor binding Interacting selectively with a M2 muscarinic acetylcholine receptor. MF
GO:0045179 apical cortex The region that lies just beneath the plasma membrane on the apical edge of a cell. CC
GO:0045178 basal part of cell The basal region of a cell. CC
GO:0031794 M5 muscarinic acetylcholine receptor binding Interacting selectively with a M5 muscarinic acetylcholine receptor. MF
GO:0031795 metabotropic GABA receptor binding Interacting selectively with a metabotropic GABA receptor. MF
GO:0009098 leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. BP
GO:0009099 valine biosynthetic process The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. BP
GO:0009096 aromatic amino acid family biosynthetic process, anthranilate pathway The pathway of tryptophan biosynthesis from chorismate via anthranilate. BP
GO:0009097 isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. BP
GO:0009094 L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid. BP
GO:0009095 aromatic amino acid family biosynthetic process, prephenate pathway The pathway of phenylalanine and tyrosine biosynthesis from chorismate, utilizing prephenate as an intermediate. BP
GO:0009092 homoserine metabolic process The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine. BP
GO:0009093 cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid. BP
GO:0009090 homoserine biosynthetic process The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid. BP
GO:0009091 homoserine catabolic process The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid. BP
GO:0008329 pattern recognition receptor activity Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens. MF
GO:0008328 ionotropic glutamate receptor complex A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the centre of the receptor complex. CC
GO:0008327 methyl-CpG binding Interacting selectively with a methylated cystine/guanine dinucleotide. MF
GO:0008326 site-specific DNA-methyltransferase (cytosine-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA 5-methylcytosine at a specific recognition sequence within the target DNA. MF
GO:0008324 cation transporter activity Enables the directed movement of atoms or small molecules with a positive charge into, out of, within or between cells. MF
GO:0008322 Pro-X carboxypeptidase activity Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid. MF
GO:0008321 Ral guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides by a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. MF
GO:0008320 protein carrier activity Catalysis of the transfer of proteins from one side of a membrane to the other. MF
GO:0031428 box C/D snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type. CC
GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. CC
GO:0031424 keratinization The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. BP
GO:0031425 chloroplast RNA processing The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules. BP
GO:0031426 polycistronic mRNA processing The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules. BP
GO:0031427 response to methotrexate A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase. BP
GO:0031420 alkali metal ion binding Interacting selectively with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. MF
GO:0031421 invertasome A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts. CC
GO:0031422 RecQ helicase-Topo III complex A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human. CC
GO:0031423 hexon binding Interacting selectively with a hexon, the major protein component of the icosahedral capsid of an adenovirus. MF
GO:0009638 phototropism The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it. BP
GO:0009639 response to red or far red light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red and far red light is that with a wavelength of above 620nm. BP
GO:0032218 riboflavin transport The directed movement of riboflavin into, out of, within or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. BP
GO:0032219 cell wall catabolic process during cytogamy The chemical reactions and pathways resulting in the breakdown of a cell wall during cytogamy. BP
GO:0032216 glucosaminyl-phosphotidylinositol O-acyltransferase activity Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA. MF
GO:0032217 riboflavin transporter activity Facilitates the directed movement of riboflavin into, out of, within or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. MF
GO:0009630 gravitropism The orientation of plant parts under the stimulation of gravity. BP
GO:0009631 cold acclimation Processes that increase freezing tolerance of an organism in response to low, nonfreezing temperatures. BP
GO:0009636 response to toxin A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus. BP
GO:0009637 response to blue light A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light has a wavelength of between 440 and 500nm. BP
GO:0032210 regulation of telomere maintenance via telomerase Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. BP
GO:0009635 response to herbicide A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants. BP
GO:0007009 plasma membrane organization and biogenesis The assembly and arrangement of the plasma membrane. BP
GO:0042318 penicillin biosynthetic process The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. BP
GO:0047148 methylamine-glutamate N-methyltransferase activity Catalysis of the reaction: L-glutamate + methylamine = N-methyl-L-glutamate + NH3. MF
GO:0047149 thetin-homocysteine S-methyltransferase activity Catalysis of the reaction: homocysteine + dimethylsulfonioacetate = L-methionine + S-methylthioglycolate. MF
GO:0047142 enzyme-thiol transhydrogenase (glutathione-disulfide) activity Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase. MF
GO:0047143 chlorate reductase activity Catalysis of the reaction: chlorate + donor-H2 = chlorite + H2O + acceptor. MF
GO:0047140 glutathione-CoA-glutathione transhydrogenase activity Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione. MF
GO:0047141 glutathione-cystine transhydrogenase activity Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine. MF
GO:0047146 sterigmatocystin 7-O-methyltransferase activity Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine. MF
GO:0047147 trimethylsulfonium-tetrahydrofolate N-methyltransferase activity Catalysis of the reaction: THF + trimethyl sulfonium = 5-methyl-THF + dimethyl sulfide. MF
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA. MF
GO:0047145 demethylsterigmatocystin 6-O-methyltransferase activity Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine. MF
GO:0006208 pyrimidine base catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine bases, 1,3-diazine, organic nitrogenous bases. BP
GO:0006209 cytosine catabolic process The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. BP
GO:0006206 pyrimidine base metabolic process The chemical reactions and pathways involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases. BP
GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. BP
GO:0006204 IMP catabolic process The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate. BP
GO:0006202 GMP catabolic process to guanine The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine. BP
GO:0006203 dGTP catabolic process The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. BP
GO:0006200 ATP catabolic process The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. BP
GO:0006201 GMP catabolic process to IMP The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate. BP
GO:0000330 vacuolar lumen (sensu Magnoliophyta) The volume enclosed within the vacuolar membrane; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). CC
GO:0000331 contractile vacuole A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory. CC
GO:0000332 template for synthesis of G-rich strand of telomere DNA activity Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA. MF
GO:0000333 telomerase catalytic core complex The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. CC
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. MF
GO:0000335 negative regulation of DNA transposition Any process that stops, prevents or reduces the frequency, rate or extent of DNA transposition. BP
GO:0000336 positive regulation of DNA transposition Any process that activates or increases the frequency, rate or extent of DNA transposition. BP
GO:0000337 regulation of DNA transposition Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule. BP
GO:0000338 protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein. BP
GO:0000339 RNA cap binding Interacting selectively with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule. MF
GO:0050898 nitrile metabolic process The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile. BP
GO:0050899 nitrile catabolic process The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom. BP
GO:0050894 determination of affect The processes by which an emotional response is associated with a particular sensory stimulation. BP
GO:0050896 response to stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. BP
GO:0050897 cobalt ion binding Interacting selectively with a cobalt (Co) ion. MF
GO:0050890 cognition The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. BP
GO:0050891 body fluid osmoregulation Any process that modulates the osmotic activity of the fluid in a tissue, organ or organism. BP
GO:0050892 intestinal absorption The processes by which nutrients are taken up from the contents of the intestine. BP
GO:0050893 sensory processing The neural processes required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect. BP
GO:0030541 plasmid partitioning Any process by which plasmids are segregated or distributed into daughter cells upon cell division. BP
GO:0050766 positive regulation of phagocytosis Any process that activates or increases the frequency, rate or extent of phagocytosis. BP
GO:0050767 regulation of neurogenesis Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons. BP
GO:0050764 regulation of phagocytosis Any process that modulates the frequency, rate or extent of phagocytosis, the process whereby phagocytes engulf external particulate material. BP
GO:0050765 negative regulation of phagocytosis Any process that stops, prevents or reduces the frequency, rate or extent of phagocytosis. BP
GO:0050762 depsipeptide catabolic process The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. BP
GO:0050763 depsipeptide biosynthetic process The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. BP
GO:0050760 negative regulation of thymidylate synthase biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase. BP
GO:0050761 depsipeptide metabolic process The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively. BP
GO:0050768 negative regulation of neurogenesis Any process that stops, prevents or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons. BP
GO:0050769 positive regulation of neurogenesis Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons. BP
GO:0048881 mechanosensory lateral line system development The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. BP
GO:0007004 telomere maintenance via telomerase The maintenace of proper telomeric length by the addition of telomeric repeats by telomerase. BP
GO:0048886 neuromast hair cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. BP
GO:0048887 cupula development The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. BP
GO:0002233 leukocyte chemotaxis during immune response The movement of an immune cell in response to an external stimulus during an immune response. BP
GO:0002232 leukocyte chemotaxis during inflammatory response The movement of an immune cell in response to an external stimulus during an inflammatory response. BP
GO:0002231 detection of oomycetes The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal. BP
GO:0002230 positive regulation of antiviral response by host Host processes that result in the promotion of antiviral immune response mechanisms, thereby limiting viral replication. BP
GO:0002237 response to molecule of bacterial origin A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of molecules of bacterial origin such as peptides derived from bacterial flagellin. BP
GO:0002236 detection of misfolded protein The series of events in which a misfolded protein stimulus is received and converted into a molecular signal. BP
GO:0002235 detection of unfolded protein The series of events in which an unfolded protein stimulus is received and converted into a molecular signal. BP
GO:0002234 detection of endoplasmic reticulum overloading The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal. BP
GO:0002239 response to oomycetes A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes. BP
GO:0002238 response to molecule of fungal origin A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of molecules of fungal origin such as chito-octomer oligosaccharide. BP
GO:0004176 ATP-dependent peptidase activity NA MF
GO:0004177 aminopeptidase activity Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides. MF
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol. MF
GO:0004175 endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites. MF
GO:0051383 kinetochore organization and biogenesis The assembly and arrangement of the kinetochore, a multisubunit complex that is located at the pericentric region of DNA and provides an attachment point for the spindle microtubules. BP
GO:0004173 ecdysone O-acyltransferase activity Catalysis of the reaction: palmitoyl-CoA + ecdysone = CoA + ecdysone palmitate. MF
GO:0004170 dUTP diphosphatase activity Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. MF
GO:0051380 norepinephrine binding Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. MF
GO:0004178 leucyl aminopeptidase activity Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro. MF
GO:0004179 membrane alanyl aminopeptidase activity Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. MF
GO:0001527 microfibril Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins. CC
GO:0001525 angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. BP
GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. BP
GO:0001523 retinoid metabolic process The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. BP
GO:0001520 outer dense fiber Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile. CC
GO:0006996 organelle organization and biogenesis The assembly and arrangement of any organelle within a cell. BP
GO:0006997 nuclear organization and biogenesis The assembly and arrangement of the nucleus. BP
GO:0006994 sterol depletion response, SREBP target gene transcriptional activation Mediated by a sterol regulatory element binding-protein (SREBP), the increase in rate or extent of transcription of nuclear target genes in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. BP
GO:0006995 cellular response to nitrogen starvation A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. BP
GO:0006992 sterol depletion response, sterol regulatory element binding-protein cleavage The proteolytic release of a transcriptionally active sterol regulatory element binding-protein (SREBP) from intracellular membranes, in response to depleted sterol levels. BP
GO:0006993 sterol depletion response, sterol regulatory element binding-protein nuclear translocation The transfer of a sterol regulatory element binding-protein (SREBP) into the nucleus across the nuclear membrane, in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. BP
GO:0006990 unfolded protein response, positive regulation of target gene transcription The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensu thes CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response. BP
GO:0006991 response to sterol depletion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. BP
GO:0006998 nuclear membrane organization and biogenesis The assembly and arrangement of the nuclear membrane. BP
GO:0006999 nuclear pore organization and biogenesis The assembly and arrangement of the nuclear pore. BP
GO:0015909 long-chain fatty acid transport The directed movement of long-chain fatty acids into, out of, within or between cells. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12. BP
GO:0015908 fatty acid transport The directed movement of fatty acids into, out of, within or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. BP
GO:0015905 bicyclomycin transport The directed movement of bicyclomycin into, out of, within or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. BP
GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). BP
GO:0015906 sulfathiazole transport The directed movement of sulfathiazole into, out of, within or between cells. Sulfathiazole is an antibacterial agent of the sulfonamide group. BP
GO:0015901 cycloheximide transport The directed movement of cycloheximide into, out of, within or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. BP
GO:0015900 benomyl transport The directed movement of benomyl into, out of, within or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit. BP
GO:0015903 fluconazole transport The directed movement of fluconazole into, out of, within or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. BP
GO:0015902 carbonyl cyanide m-chlorophenylhydrazone transport The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of, within or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. BP
GO:0051602 response to electrical stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. BP
GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein during the chemical reactions and pathways resulting in the breakdown of a protein. BP
GO:0051600 regulation of exocyst localization during endocytosis Any process that modulates the localization of exocysts during endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. BP
GO:0051601 exocyst localization The processes by which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. BP
GO:0051606 detection of stimulus The series of events in which a stimulus is received by a cell and converted into a molecular signal. BP
GO:0051607 defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism. BP
GO:0051604 protein maturation The process leading to the attainment of the full functional capacity of a protein. BP
GO:0051605 protein maturation via proteolysis The hydrolysis of a peptide bond or bonds within a protein during protein maturation, the process leading to the attainment of the full functional capacity of a protein. BP
GO:0051608 histamine transport The directed movement of histamine into, out of, within or between cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. BP
GO:0051609 inhibition of neurotransmitter uptake Any process that prevents the activation of the directed movement of a neurotransmitter into a cell. BP
GO:0008129 actinidain activity Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'. MF
GO:0008125 pancreatic elastase I activity Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa. MF
GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. MF
GO:0008127 quercetin 2,3-dioxygenase activity Catalysis of the reaction: quercetin + O2 = 2-protocatechuoylphloroglucinolcarboxylate + CO. MF
GO:0008126 acetylesterase activity Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. MF
GO:0008121 ubiquinol-cytochrome-c reductase activity Catalysis of the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c. MF
GO:0008120 ceramide glucosyltransferase activity Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. MF
GO:0008123 cholesterol 7-alpha-monooxygenase activity Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. MF
GO:0008697 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Catalysis of the reaction: 4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. MF
GO:0008696 4-amino-4-deoxychorismate lyase activity Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate. MF
GO:0008695 3-phenylpropionate dioxygenase activity Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol. MF
GO:0008694 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity NA MF
GO:0008693 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. MF
GO:0008692 3-hydroxybutyryl-CoA epimerase activity Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. MF
GO:0008691 3-hydroxybutyryl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+. MF
GO:0008690 3-deoxy-manno-octulosonate cytidylyltransferase activity Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. MF
GO:0022011 myelination in the peripheral nervous system The process during which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. BP
GO:0022010 myelination in the central nervous system The process during which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. BP
GO:0022013 pallium cell proliferation in the forebrain The multiplication or reproduction of pallium cells in the forebrain, resulting in the rapid expansion of the cell population. BP
GO:0022012 subpallium cell proliferation in the forebrain The multiplication or reproduction of subpallium cells in the forebrain, resulting in the rapid expansion of a cell population. BP
GO:0022015 radial glial cell division in the pallium The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes. BP
GO:0022014 radial glial cell division in the subpallium The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes. BP
GO:0022017 neuroblast division in the pallium The division of neuroblast in the pallium. Neuroblasts are precursor cells that give rise to neurons. BP
GO:0022016 glioblast cell division in the pallium The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells. BP
GO:0022019 dorsal lateral ganglionic eminence cell proliferation The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the rapid expansion of the cell population. BP
GO:0022018 lateral ganglionic eminence cell proliferation The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the rapid expansion of the cell population. BP
GO:0009875 pollen-pistil interaction The interaction between a pollen grain and pistil. BP
GO:0009876 pollen adhesion The process by which pollen deposited on the stigma adheres to cells of the stigma. BP
GO:0009877 nodulation The formation of nitrogen-fixing root nodules on plant roots. BP
GO:0043137 DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease. BP
GO:0009871 jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance. BP
GO:0009873 ethylene mediated signaling pathway A series of molecular signals mediated by ethylene (ethene). BP
GO:0047788 2-coumarate reductase activity Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = 2-coumarate + NADH. MF
GO:0047789 creatininase activity Catalysis of the reaction: creatinine + H2O = creatine. MF
GO:0047780 citrate dehydratase activity Catalysis of the reaction: citrate = cis-aconitate + H2O. MF
GO:0047781 citrullinase activity Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine. MF
GO:0047782 coniferin beta-glucosidase activity Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol. MF
GO:0047783 corticosterone 18-monooxygenase activity Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. MF
GO:0047784 cortisol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate. MF
GO:0047785 cortisol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate. MF
GO:0047786 cortisone alpha-reductase activity Catalysis of the reaction: 4,5-alpha-dihydrocortisone + NADP+ = cortisone + NADPH. MF
GO:0047787 cortisone beta-reductase activity Catalysis of the reaction: 4,5-beta-dihydrocortisone + NADP+ = cortisone + NADPH. MF
GO:0043498 cell surface binding Interacting selectively with any component on the surface of a cell. MF
GO:0043499 eukaryotic cell surface binding Interacting selectively with any component on the surface of a eukaryotic cell. MF
GO:0043490 malate-aspartate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle. BP
GO:0043491 protein kinase B signaling cascade A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound. BP
GO:0043492 ATPase activity, coupled to movement of substances Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance. MF
GO:0043493 phage terminase complex A complex of a large and small subunit which catalyze the packaging of DNA into phage heads. Note that not all phage terminases have this structure, some exist as single polypeptides. CC
GO:0043494 Rik1-E3 ubiquitin ligase complex A protein complex that consists of (minimally) cullin, RING finger, methyltransferase, Rik1 WD repeat protein, Raf1 and Raf2. Required to regulate heterchromatin formation by RNAi and for histone H3K9 methylation. CC
GO:0043495 protein anchor Interacting selectively with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane. MF
GO:0043496 regulation of protein homodimerization Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. BP
GO:0043497 regulation of protein heterodimerization Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer. BP
GO:0016463 zinc-exporting ATPase activity Catalysis of the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out). MF
GO:0016462 pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond between two phosphoric groups, leaving one phosphate on each of the two fragments. MF
GO:0016461 unconventional myosin complex A portmanteau term for myosins other than myosin II. CC
GO:0016460 myosin II complex A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. CC
GO:0016465 chaperonin ATPase complex Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. CC
GO:0016464 chloroplast protein-transporting ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma. MF
GO:0016469 proton-transporting two-sector ATPase complex A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F0, V0, A0) and a cytoplasmic compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archebacterial) enzymes have a similar structure but, under physiological conditions, they pump hydrogen ion rather than synthesize ATP. CC
GO:0046787 viral DNA repair The process of restoring viral DNA after damage or errors in replication. BP
GO:0046786 viral replication complex formation and maintenance The process of organizing and assembling viral replication proteins in preparation for viral replication. BP
GO:0046785 microtubule polymerization The addition of tubulin heterodimers to one or both ends of a microtubule. BP
GO:0046784 intronless viral mRNA export from host nucleus The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation. BP
GO:0046783 modification by virus of host polysomes Viral processes that interfere with and inhibit the assembly and function of polysomes. BP
GO:0046782 regulation of viral transcription Any process that modulates the frequency, rate or extent of the transcription of the viral genome. BP
GO:0046781 dispersion by virus of host splicing factors Viral processes that disperse host splicing factors (snRNPs) to prevent host mRNA splicing, thus reducing host protein production. BP
GO:0046780 suppression by virus of host mRNA splicing Viral processes that inhibit the splicing of host mRNA, thus reducing host protein production. BP
GO:0046789 host cell surface receptor binding Interacting selectively with a receptor on the host cell surface. MF
GO:0046788 egress of virus within host cell The process of moving the (often) incomplete virion to the cell surface in order to be released from the cell. Egress can involve travel through the endoplasmic reticulum or cytoplasm and will often include final maturation stages of the virion, but it occurs entirely within the cell. BP
GO:0030098 lymphocyte differentiation The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells. BP
GO:0030099 myeloid cell differentiation The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. BP
GO:0030096 photosystem II (sensu CyanoBacteria) Photosystem II; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117). CC
GO:0030097 hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. BP
GO:0030094 photosystem I (sensu CyanoBacteria) Photosystem I; as in, but not restricted to, the blue-green algae (Cyanobacteria, ncbi_taxonomy_id:1117). CC
GO:0030095 photosystem II (sensu Viridiplantae) Photosystem II; as in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0030092 regulation of flagellum biogenesis Any process that modulates the frequency, rate or extent of the formation of a flagellum. BP
GO:0030093 photosystem I (sensu Viridiplantae) Photosystem I; as in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090). CC
GO:0030090 reaction center (sensu ProteoBacteria) A complex of photosynthetic and accessory pigments and electron carriers that operate in sequence to perform the two light reactions of photosynthesis. As in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224). CC
GO:0030091 protein repair The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. BP
GO:0031329 regulation of cellular catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. BP
GO:0031328 positive regulation of cellular biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. BP
GO:0031327 negative regulation of cellular biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. BP
GO:0031326 regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. BP
GO:0031325 positive regulation of cellular metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. BP
GO:0031324 negative regulation of cellular metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. BP
GO:0031323 regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. BP
GO:0031322 prospore-specific spindle pole body modification Structural modification of the spindle pole body that takes place during the second meiotic division; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP). BP
GO:0031321 prospore formation During fungal sporulation, the process by which each haploid nucleus becomes encapsulated by a double membrane. BP
GO:0031320 hexitol dehydrogenase activity Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor. MF
GO:0048437 floral organ development The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure. BP
GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. MF
GO:0001986 decreased strength of heart contraction during baroreceptor response to increased blood pressure Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure. BP
GO:0042287 MHC protein binding Interacting selectively with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. MF
GO:0042284 sphingolipid delta-4 desaturase activity Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid. MF
GO:0048439 flower morphogenesis The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048438 floral whorl development The process whose specific outcome is the progression of the floral whorl over time, from its formation to the mature structure. BP
GO:0042285 xylosyltransferase activity Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. MF
GO:0042282 hydroxymethylglutaryl-CoA reductase activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+. MF
GO:0042283 dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. MF
GO:0050407 [glycogen-synthase-D] phosphatase activity Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate. MF
GO:0050406 [acetyl-CoA carboxylase]-phosphatase activity Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate. MF
GO:0050405 [acetyl-CoA carboxylase] kinase activity Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate. MF
GO:0050404 zeatin O-beta-D-xylosyltransferase activity Catalysis of the reaction: UDP-D-xylose + zeatin = UDP + O-beta-D-xylosylzeatin. MF
GO:0050403 trans-zeatin O-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + trans-zeatin = UDP + O-beta-D-glucosyl-trans-zeatin. MF
GO:0050402 xylono-1,4-lactonase activity Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate. MF
GO:0050401 xylonate dehydratase activity Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-xylonate + H2O. MF
GO:0050400 xylitol kinase activity Catalysis of the reaction: ATP + xylitol = ADP + xylitol 5-phosphate. MF
GO:0042281 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. MF
GO:0050409 indolylacetylinositol arabinosyltransferase activity Catalysis of the reaction: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside. MF
GO:0050408 [pyruvate kinase]-phosphatase activity Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate. MF
GO:0030638 polyketide metabolic process The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps. BP
GO:0030639 polyketide biosynthetic process The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps. BP
GO:0030632 D-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of D-alanine, the dextrorotatory isomer of the amino acid alanine. BP
GO:0030633 D-alanine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids. BP
GO:0030631 lysine methylamine methyltransferase cofactor adduct incorporation The incorporation of a lysine methylamine methyltransferase cofactor adduct into a peptide; uses a special tRNA that recognizes the UGA codon as a modified lysine, rather than as a termination codon. The lysine methylamine methyltransferase cofactor adduct is synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases. BP
GO:0030636 acetate derivative biosynthetic process The chemical reactions and pathways resulting in the formation of derivatives of acetic acid. BP
GO:0030637 acetate derivative catabolic process The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid. BP
GO:0030634 carbon fixation by acetyl-CoA pathway A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2). BP
GO:0030635 acetate derivative metabolic process The chemical reactions and pathways involving derivatives of acetic acid. BP
GO:0018854 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. MF
GO:0018855 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA. MF
GO:0018856 benzoyl acetate-CoA ligase activity Catalysis of the reaction: benzoyl acetate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA. MF
GO:0018857 2,4-dichlorobenzoate-CoA ligase activity Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA. MF
GO:0018850 chloromuconate cycloisomerase activity Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. MF
GO:0018851 alpha-pinene-oxide decyclase activity Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal. MF
GO:0018852 dichloromuconate cycloisomerase activity Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate. MF
GO:0018853 perillyl-CoA synthetase activity Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA. MF
GO:0018858 benzoate-CoA ligase activity Catalysis of the reaction: ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA. Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates. MF
GO:0018859 4-hydroxybenzoate-CoA ligase activity Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA. MF
GO:0000907 sulfonate dioxygenase activity Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2. MF
GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. MF
GO:0000905 fruiting body development during asexual reproduction (sensu Fungi) The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0000904 cellular morphogenesis during differentiation The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. BP
GO:0000903 cellular morphogenesis during vegetative growth The change in form (cell shape and size) that occurs during the development of a cell as it progresses through a mitotic cell cycle when it is not undergoing terminal differentiation. BP
GO:0000902 cell morphogenesis Any process that modulates the mass, volume, or shape of a cell. BP
GO:0000901 translation repressor activity, non-nucleic acid binding Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid. MF
GO:0000900 translation repressor activity, nucleic acid binding Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid. MF
GO:0000909 fruiting body development during sexual reproduction (sensu Fungi) The formation of a spore-bearing structure by fungus where spores will arise from sexual reproduction. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751). BP
GO:0000908 taurine dioxygenase activity Catalysis of the reaction: taurine + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2. MF
GO:0032009 early phagosome A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis. CC
GO:0032008 positive regulation of TOR signaling pathway Any process that activates or increases the frequency, rate or extent of the TOR signaling pathway. BP
GO:0032007 negative regulation of TOR signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the TOR signaling pathway. BP
GO:0032006 regulation of TOR signaling pathway Any process that modulates the frequency, rate or extent of the TOR signaling pathway. BP
GO:0032005 signal transduction during conjugation with cellular fusion The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. BP
GO:0032003 interleukin-28 receptor binding Interacting selectively with the interleukin-27 receptor. MF
GO:0032002 interleukin-28 receptor complex A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta. CC
GO:0032001 1,4-alpha-glucan 6-alpha-glucosyltransferase activity Catalysis of the transfer an alpha-D-glucosyl residue in a 1,4-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a 1,4-alpha-D-glucan. MF
GO:0032000 positive regulation of fatty acid beta-oxidation Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation. BP
GO:0019819 P1 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms. CC
GO:0019817 vesicle fusion with peroxisome The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome. BP
GO:0019815 B cell receptor complex A membrane-bound antigen receptor complex consisting in its basic form of an antigen-binding subunit (the membrane immunoglobulin or mIg), comprised of two identical heavy chains and two identical light chains held together by disulfide bonds, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. CC
GO:0019814 immunoglobulin complex A multiprotein complex that functions as an antibody. Immunoglobulins (Igs) are composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. The classes of Ig are IgA, IgD, IgE, IgG and IgM; they may be embedded in the plasma membrane or circulate in the blood or lymph. CC
GO:0019813 Type III site-specific deoxyribonuclease complex A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. CC
GO:0019812 Type I site-specific deoxyribonuclease complex A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell. CC
GO:0019811 cocaine binding Interacting selectively with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis. MF
GO:0019810 putrescine binding Interacting selectively with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. MF
GO:0002413 tolerance induction to tumor cell A process of tolerance induction which leads to immunological tolerance of a tumor. BP
GO:0002412 antigen transcytosis by M cells in mucosal-associated lymphoid tissue The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT. BP
GO:0002411 T cell tolerance induction to tumor cell A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor. BP
GO:0002410 plasmacytoid dendritic cell chemotaxis The movement of a plasmacytoid dendritic cell in response to an external stimulus. BP
GO:0002417 B cell antigen processing and presentation mediated by B cell receptor uptake of antigen B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor. BP
GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals. BP
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa. BP
GO:0002414 immunoglobulin transcytosis in epithelial cells The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other. BP
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. BP
GO:0002418 immune response to tumor cell An immune system process that functions in the response of an organism to a tumor cell. BP
GO:0009003 signal peptidase activity Catalysis of the cleavage of a signal peptide from a protein precursor. MF
GO:0042509 regulation of tyrosine phosphorylation of STAT protein Any process that modulates the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. BP
GO:0042508 tyrosine phosphorylation of Stat1 protein The process of introducing a phosphoric group to a tyrosine residue of a Stat1 protein. BP
GO:0042501 serine phosphorylation of STAT protein The process of introducing a phosphoric group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. BP
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, occurring within the plasma membrane. MF
GO:0042503 tyrosine phosphorylation of Stat3 protein The process of introducing a phosphoric group to a tyrosine residue of a Stat3 protein. BP
GO:0042502 tyrosine phosphorylation of Stat2 protein The process of introducing a phosphoric group to a tyrosine residue of a Stat2 protein. BP
GO:0042505 tyrosine phosphorylation of Stat6 protein The process of introducing a phosphoric group to a tyrosine residue of a Stat6 protein. BP
GO:0042504 tyrosine phosphorylation of Stat4 protein The process of introducing a phosphoric group to a tyrosine residue of a Stat4 protein. BP
GO:0042507 tyrosine phosphorylation of Stat7 protein The process of introducing a phosphoric group to a tyrosine residue of a Stat7 protein. BP
GO:0042506 tyrosine phosphorylation of Stat5 protein The process of introducing a phosphoric group to a tyrosine residue of a Stat5 protein. BP
GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. BP
GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. BP
GO:0006417 regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. BP
GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). BP
GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. BP
GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. BP
GO:0006412 translation The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. BP
GO:0006410 transcription, RNA-dependent The synthesis of DNA on a template of RNA. BP
GO:0005148 prolactin receptor binding Interacting selectively with the prolactin receptor. MF
GO:0048779 negative regulation of erythrophore differentiation Any process that stops, prevents or reduces the frequency, rate or extent of erythrophore differentiation. BP
GO:0048774 cyanophore differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes. BP
GO:0048775 regulation of leucophore differentiation Any process that modulates the frequency, rate or extent of leucophore differentiation. BP
GO:0005146 leukemia inhibitory factor receptor binding Interacting selectively with the leukemia inhibitory factor receptor. MF
GO:0048777 positive regulation of leucophore differentiation Any process that activates or increases the frequency, rate or extent of leucophore differentiation. BP
GO:0048770 pigment granule A small, subcellular membrane-bound vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. CC
GO:0048771 tissue remodeling The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. BP
GO:0048772 leucophore differentiation The process whereby a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance. BP
GO:0048773 erythrophore differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance. BP
GO:0004811 tRNA isopentenyltransferase activity Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. MF
GO:0004810 tRNA adenylyltransferase activity Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1). MF
GO:0004813 alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). MF
GO:0004812 aminoacyl-tRNA ligase activity Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. MF
GO:0004815 aspartate-tRNA ligase activity Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). MF
GO:0004814 arginine-tRNA ligase activity Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). MF
GO:0004817 cysteine-tRNA ligase activity Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). MF
GO:0004816 asparagine-tRNA ligase activity Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). MF
GO:0004819 glutamine-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). MF
GO:0004818 glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). MF
GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). BP
GO:0051022 Rho GDP-dissociation inhibitor binding Interacting selectively with a Rho GDP-dissociation inhibitor protein. MF
GO:0051023 regulation of immunoglobulin secretion Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells. BP
GO:0051020 GTPase binding Interacting selectively with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. MF
GO:0051021 GDP-dissociation inhibitor binding Interacting selectively with a GDP-dissociation inhibitor protein. MF
GO:0051026 chiasma formation The cell cycle process whereby a connection between chromatids forms, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids. BP
GO:0051027 DNA transport The directed movement of RNA, deoxyribonucleic acid, into, out of, within or between cells. BP
GO:0051024 positive regulation of immunoglobulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells. BP
GO:0051025 negative regulation of immunoglobulin secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells. BP
GO:0051028 mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of, within or between cells. BP
GO:0051029 rRNA transport The directed movement of rRNA, ribosomal ribonucleic acid, into, out of, within or between cells. BP
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway The pathway that converts actetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols. BP
GO:0007437 adult salivary gland morphogenesis The process by which the anatomical structures of the adult salivary gland are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0007434 adult salivary gland determination Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. BP
GO:0007435 salivary gland morphogenesis The process by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0010146 fructan biosynthetic process The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues. BP
GO:0010147 fructan catabolic process The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues. BP
GO:0007430 terminal branching of trachea, cytoplasmic projection extension (sensu Insecta) Formation of terminal branches in the tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557). BP
GO:0015317 phosphate:hydrogen symporter activity Catalysis of the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in). MF
GO:0015318 inorganic uptake permease activity NA MF
GO:0015319 sodium:inorganic phosphate symporter activity Catalysis of the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in). MF
GO:0010148 transpiration Release of water by the plant into the air as water vapor mainly through leaves. BP
GO:0010149 senescence (sensu Magnoliophyta) The process that occurs in an organism near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398). BP
GO:0007438 oenocyte development The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. BP
GO:0007439 ectodermal gut development The process whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. The ectodermal gut includes those portions of the gut that are derived from ectoderm. BP
GO:0018331 enzyme active site formation via O-phospho-L-serine The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine. BP
GO:0018330 enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme. BP
GO:0018333 enzyme active site formation via O-phospho-L-threonine The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine. BP
GO:0018332 enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I. BP
GO:0018335 protein amino acid succinylation The modification of a protein amino acid by succinylation. BP
GO:0018334 enzyme active site formation via O4'-phospho-L-tyrosine The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine. BP
GO:0018336 peptidyl-tyrosine hydroxylation The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine. BP
GO:0018339 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid The posttranslation modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12. BP
GO:0016277 [myelin basic protein]-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine. MF
GO:0046002 positive regulation of progression through preblastoderm mitotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the preblastoderm mitotic cell cycle. BP
GO:0046003 negative regulation of progression through syncytial blastoderm mitotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of progression through the syncytial blastoderm mitotic cell cycle. BP
GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. CC
GO:0016273 arginine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue. MF
GO:0016270 O-glycan processing, core 4 The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-1->6(GlcNAc-beta-1->3)-GalNAc. BP
GO:0035125 embryonic anal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. BP
GO:0016271 tissue death NA BP
GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0016663 oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen. MF
GO:0016662 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome. MF
GO:0021959 cuneatus tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal processes is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb. BP
GO:0021958 gracilis tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal processes is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb. BP
GO:0016667 oxidoreductase activity, acting on sulfur group of donors Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. MF
GO:0021955 central nervous system neuron axonogenesis Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. BP
GO:0021954 central nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. BP
GO:0021957 corticospinal tract morphogenesis Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal processes is a member of those that make up the corticospinal tract. BP
GO:0021956 central nervous system interneuron axonogenesis Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region. BP
GO:0021951 chemoattraction involved in precerebellar neuron migration The creation and reception of signals that guide precerebellar neurons towards their signals, where this process is involved in tangential migration. BP
GO:0021950 chemorepulsion involved in precerebellar neuron migration The creation and reception of signals that repel precerebellar neurons as a component of the process of tangential migration. BP
GO:0021953 central nervous system neuron differentiation The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. BP
GO:0021952 central nervous system projection neuron axonogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. BP
GO:0035124 embryonic caudal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. BP
GO:0005049 nuclear export signal receptor activity Combining with a nuclear export signal to initiate a change in cell activity. MF
GO:0005048 signal sequence binding Interacting selectively with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. MF
GO:0052045 upregulation by symbiont of host programmed cell death Any process by which an organism increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052044 induction by symbiont of host programmed cell death The activation by an organism of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052047 interaction with other organism via secreted substance during symbiotic interaction An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction. BP
GO:0052046 modification by symbiont of host morphology or physiology via secreted substance The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052041 negative regulation by symbiont of host programmed cell death Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052040 modulation by symbiont of host programmed cell death Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052043 modification by symbiont of host cellular component The process by which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052042 positive regulation by symbiont of host programmed cell death Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052049 interaction with host via protein secreted by type III secretion system An interaction with the host organism mediated by a substance secreted by the other organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0052048 interaction with host via secreted substance An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. BP
GO:0019178 NADP phosphatase activity Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate. MF
GO:0035194 RNA-mediated posttranscriptional gene silencing Any process of gene inactivation (silencing) in which small RNAs trigger degradation of mRNA. BP
GO:0005044 scavenger receptor activity Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity. MF
GO:0019170 D-lactaldehyde dehydrogenase activity Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+. MF
GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: CH3-CHOH-CH2-[CH2]n-CO-[acyl-carrier protein] = H2O + CH3-CH-CH-[CH2]n-CO-[acyl-carrier protein]. MF
GO:0019172 glyoxalase III activity Catalysis of the reaction: methylglyoxal + H2O = D-lactate. MF
GO:0019173 pyrimidine phosphatase activity NA MF
GO:0019174 tetrahydrothiophene 1-oxide reductase activity Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor. MF
GO:0035196 miRNA-mediated gene silencing, production of miRNAs Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein. BP
GO:0019176 dihydroneopterin monophosphate phosphatase activity Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate. MF
GO:0019177 dihydroneopterin triphosphate pyrophosphohydrolase activity Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. MF
GO:0002014 vasoconstriction of artery during ischemic response to lowering of blood pressure A process that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system. BP
GO:0035126 post-embryonic genitalia morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0048851 hypophysis formation The process by which the anatomical structures of the hypophysis are generated and organized. Morphogenesis pertains to the creation of form. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands. BP
GO:0002012 vasoconstriction of artery during chemoreceptor response to lowering of blood pressure A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. BP
GO:0035192 nuclear cortical migration The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo. BP
GO:0002010 excitation of vasomotor center by baroreceptor signaling The process by which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure. BP
GO:0031129 inductive cell-cell signaling Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate. BP
GO:0031128 induction Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other. BP
GO:0031125 rRNA 3'-end processing Any process involved in forming the mature 3' end of an rRNA molecule. BP
GO:0031124 mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule. BP
GO:0031127 alpha(1,2)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,2)-linkage. MF
GO:0031126 snoRNA 3'-end processing Any process involved in forming the mature 3' end of a snoRNA molecule. BP
GO:0031121 equatorial microtubule organization and biogenesis The assembly and arrangement of structures formed of microtubules and associated proteins at the midpoint of a cell. BP
GO:0031120 snRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. BP
GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. BP
GO:0031122 cytoplasmic microtubule organization and biogenesis The assembly and arrangement of structures formed of microtubules and associated proteins in the cytoplasm of a cell. BP
GO:0031697 beta-1 adrenergic receptor binding Interacting selectively with a beta-1 adrenergic receptor. MF
GO:0031696 alpha-2C adrenergic receptor binding Interacting selectively with an alpha-2C adrenergic receptor. MF
GO:0031695 alpha-2B adrenergic receptor binding Interacting selectively with an alpha-2B adrenergic receptor. MF
GO:0031694 alpha-2A adrenergic receptor binding Interacting selectively with an alpha-2A adrenergic receptor. MF
GO:0031693 alpha-1D adrenergic receptor binding Interacting selectively with an alpha-1D adrenergic receptor. MF
GO:0031692 alpha-1B adrenergic receptor binding Interacting selectively with an alpha-1B adrenergic receptor. MF
GO:0031691 alpha-1A adrenergic receptor binding Interacting selectively with an alpha-1A adrenergic receptor. MF
GO:0031690 adrenergic receptor binding Interacting selectively with an adrenergic receptor. MF
GO:0031699 beta-3 adrenergic receptor binding Interacting selectively with a beta-3 adrenergic receptor. MF
GO:0031698 beta-2 adrenergic receptor binding Interacting selectively with a beta-2 adrenergic receptor. MF
GO:0051813 active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism during symbiotic interaction Any process by which an organism avoids the immune response of a second organism by regulating the second organism's antigen processing or presentation pathways, where the two organisms are in a symbiotic interaction. BP
GO:0051812 active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction Any process by which an organism avoids the immune response of a second organism by regulating the second organism's cytokine networks, where the two organisms are in a symbiotic interaction. BP
GO:0051811 active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction Any process by which an organism avoids the immune response of a second organism by regulating the second organism's complement system, where the two organisms are in a symbiotic interaction. BP
GO:0051810 active evasion of immune response of other organism during symbiotic interaction Any process by which an organism avoids the immune response of a second organism which directly affects the second organism's immune system, where the two organisms are in a symbiotic interaction. BP
GO:0051817 modification of morphology or physiology of other organism during symbiotic interaction The process by which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051816 acquisition of nutrients from other organism during symbiotic interaction The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051815 migration within other organism during symbiotic interaction The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051814 movement within other organism during symbiotic interaction The process by which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051819 induction of tumor, nodule, or growth in other organism during symbiotic interaction The process by which an organism causes the formation of an abnormal mass of cells in a second organism, where the two organisms are in a symbiotic interaction. BP
GO:0051818 disruption of cells of other organism during symbiotic interaction A process by which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. BP
GO:0009449 gamma-aminobutyric acid biosynthetic process The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. BP
GO:0009448 gamma-aminobutyric acid metabolic process The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. BP
GO:0009445 putrescine metabolic process The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine. BP
GO:0009444 pyruvate oxidation NA BP
GO:0009447 putrescine catabolic process The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. BP
GO:0009446 putrescine biosynthetic process The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine. BP
GO:0009441 glycolate metabolic process The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid). BP
GO:0009440 cyanate catabolic process The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid. BP
GO:0009443 pyridoxal 5'-phosphate salvage Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. BP
GO:0009442 allantoin assimilation pathway The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP. BP
GO:0008712 ADP-glyceromanno-heptose 6-epimerase activity Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. MF
GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity NA MF
GO:0008710 8-amino-7-oxononanoate synthase activity Catalysis of the reaction: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2. MF
GO:0008711 ADP-L-glycero-D-manno-heptose synthase activity NA MF
GO:0008716 D-alanine-D-alanine ligase activity Catalysis of the reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. MF
GO:0008717 D-alanyl-D-alanine endopeptidase activity NA MF
GO:0008714 AMP nucleosidase activity Catalysis of the reaction: AMP + H2O = adenine + D-ribose 5-phosphate. MF
GO:0008715 CDP-diacylglycerol diphosphatase activity Catalysis of the reaction: CDP-diacylglycerol + H2O = CMP + phosphatidate. MF
GO:0008718 D-amino-acid dehydrogenase activity Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. MF
GO:0008719 dihydroneopterin triphosphate 2'-epimerase activity Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate. MF
GO:0045429 positive regulation of nitric oxide biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. BP
GO:0045428 regulation of nitric oxide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. BP
GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor. BP
GO:0045422 positive regulation of connective tissue growth factor biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor. BP
GO:0045421 negative regulation of connective tissue growth factor biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor. BP
GO:0045420 regulation of connective tissue growth factor biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor. BP
GO:0045427 enzyme active site formation via (phospho-5'-guanosine)-L-histidine The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine. BP
GO:0045426 quinone cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of any quinone cofactor, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1). BP
GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor. BP
GO:0045424 negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor. BP
GO:0035009 negative regulation of melanization defense response Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection. BP
GO:0047379 ADP-dependent short-chain-acyl-CoA hydrolase activity Catalysis of the reaction: H2O + acyl-CoA = an acid + CoA. MF
GO:0047378 acetylalkylglycerol acetylhydrolase activity Catalysis of the reaction: H2O + 2-acetyl-1-alkyl-sn-glycerol = acetate + 1-alkyl-sn-glycerol. MF
GO:0047375 N-acetylgalactosaminoglycan deacetylase activity Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan. MF
GO:0047374 methylumbelliferyl-acetate deacetylase activity Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = acetate + 4-methylumbelliferone. MF
GO:0047377 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity Catalysis of the reaction: H2O + 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene = acetate + 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene. MF
GO:0047376 all-trans-retinyl-palmitate hydrolase activity Catalysis of the reaction: H2O + retinol-palmitate = palmitate + retinol. MF
GO:0047371 butyrate-acetoacetate CoA-transferase activity Catalysis of the reaction: acetoacetate + butyryl-CoA = acetoacetyl-CoA + butyrate. MF
GO:0047370 succinate-citramalate CoA-transferase activity Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate. MF
GO:0047373 acetoxybutynylbithiophene deacetylase activity Catalysis of the reaction: H2O + 5-(4-acetoxybut-1-ynyl)-2-2'-bithiophene = acetate + 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene. MF
GO:0047372 acylglycerol lipase activity Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. MF
GO:0046422 violaxanthin de-epoxidase activity Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H20. MF
GO:0046423 allene-oxide cyclase activity Catalysis of the reaction: (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate. MF
GO:0046421 methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. MF
GO:0046426 negative regulation of JAK-STAT cascade Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. BP
GO:0046427 positive regulation of JAK-STAT cascade Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. BP
GO:0046424 ferulate 5-hydroxylase activity Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+. MF
GO:0046425 regulation of JAK-STAT cascade Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. BP
GO:0046428 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + pyrophosphate + CO2. MF
GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. MF
GO:0002710 negative regulation of T cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. BP
GO:0002711 positive regulation of T cell mediated immunity Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. BP
GO:0002712 regulation of B cell mediated immunity Any process that modulates the frequency, rate, or extent of B cell mediated immunity. BP
GO:0002713 negative regulation of B cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity. BP
GO:0002714 positive regulation of B cell mediated immunity Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. BP
GO:0002715 regulation of natural killer cell mediated immunity Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. BP
GO:0002716 negative regulation of natural killer cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. BP
GO:0002717 positive regulation of natural killer cell mediated immunity Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. BP
GO:0002718 regulation of cytokine production during immune response Any process that modulates the frequency, rate, or extent of cytokine production during immune response. BP
GO:0002719 negative regulation of cytokine production during immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production during immune response. BP
GO:0035109 limb morphogenesis (sensu Endopterygota) The process by which the anatomical structures of limbs are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392). BP
GO:0035108 limb morphogenesis The process by which the anatomical structures of limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. For example a leg, arm or some types of fin. BP
GO:0035103 sterol regulatory element binding-protein cleavage The proteolytic release of a transcriptionally active sterol regulatory element binding-protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes. BP
GO:0035102 PRC1 complex An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays. CC
GO:0035101 FACT complex An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer. CC
GO:0035100 ecdysone binding Interacting selectively with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting. MF
GO:0035107 appendage morphogenesis The process by which the anatomical structures of appendages are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch. BP
GO:0035106 operant conditioning Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior. BP
GO:0035105 sterol regulatory element binding-protein nuclear translocation The transfer of a sterol regulatory element binding-protein (SREBP) into the nucleus, across the nuclear membrane. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. BP
GO:0035104 positive regulation of sterol regulatory element binding-protein target gene transcription Increasing the rate or extent of transcription of nuclear target genes, mediated by a sterol regulatory element binding-protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs in the promoters of target genes. BP
GO:0047599 8-oxocoformycin reductase activity Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + NADPH + H+. MF
GO:0047598 7-dehydrocholesterol reductase activity Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. MF
GO:0047591 5-hydroxypentanoate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + 5-hydroxypentanoate = acetate + 5-hydroxy-pentanoyl-CoA. MF
GO:0047590 5-dehydro-2-deoxygluconokinase activity Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. MF
GO:0047593 6-acetylglucose deacetylase activity Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate. MF
GO:0047592 5-pyridoxate dioxygenase activity Catalysis of the reaction: 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+. MF
GO:0047595 6-hydroxynicotinate reductase activity Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin. MF
GO:0047594 6-beta-hydroxyhyoscyamine epoxidase activity Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2. MF
GO:0047597 6-oxocineole dehydrogenase activity Catalysis of the reaction: 6-oxocineole + NADPH + H+ + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo-[3.2.2]nonan-3-one + NADP+ + H2O. MF
GO:0047596 6-methylsalicylate decarboxylase activity Catalysis of the reaction: 6-methylsalicylate = 3-cresol + CO2. MF
GO:0043289 apocarotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid. BP
GO:0043288 apocarotenoid metabolic process The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid. BP
GO:0043281 regulation of caspase activity Any process that modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. BP
GO:0043280 positive regulation of caspase activity Any process that activates or increases the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. BP
GO:0043283 biopolymer metabolic process The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. BP
GO:0043282 pharyngeal muscle development The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. The pharyngeal muscle mediates feeding in nematodes. BP
GO:0043285 biopolymer catabolic process The chemical reactions and pathways resulting in the breakdown of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. BP
GO:0043284 biopolymer biosynthetic process The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. BP
GO:0043287 poly(3-hydroxyalkanoate) binding Interacting selectively with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. MF
GO:0043286 regulation of poly(3-hydroxyalkanoate) biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. BP
GO:0048572 short-day photoperiodism A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a daylength that falls short of a particular duration known as the 'critical daylength'. The critical daylength varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical daylength. BP
GO:0048573 photoperiodism, flowering A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical daylength'. The critical daylength varies between species. BP
GO:0048570 notochord morphogenesis The process by which the anatomical structures of the notochord are generated and organized. Morphogenesis pertains to the creation of form. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. BP
GO:0048571 long-day photoperiodism A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a daylength that exceeds a particular duration known as the 'critical daylength'. The critical daylength varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical daylength. BP
GO:0048576 positive regulation of short-day photoperiodism, flowering Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. BP
GO:0048577 negative regulation of short-day photoperiodism, flowering Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. BP
GO:0048574 long-day photoperiodism, flowering A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical daylength. The critical daylength varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical daylength. BP
GO:0048575 short-day photoperiodism, flowering A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical daylength. The critical daylength varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical daylength. BP
GO:0048578 positive regulation of long-day photoperiodism, flowering Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. BP
GO:0048579 negative regulation of long-day photoperiodism, flowering Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. BP
GO:0045993 negative regulation of translational initiation by iron Any process involving iron that stops, prevents or reduces the rate of translational initiation. BP
GO:0045992 negative regulation of embryonic development Any process that stops, prevents or reduces the frequency, rate or extent of embryonic development. BP
GO:0045991 positive regulation of transcription by carbon catabolites Any process involving carbon catabolites that activates or increases the rate of transcription. BP
GO:0045990 regulation of transcription by carbon catabolites Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription. BP
GO:0045997 negative regulation of ecdysteroid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. BP
GO:0045996 negative regulation of transcription by pheromones Any process involving pheromones that stops, prevents or reduces the rate of transcription. BP
GO:0045995 regulation of embryonic development Any process that modulates the frequency, rate or extent of embryonic development. BP
GO:0045994 positive regulation of translational initiation by iron Any process involving iron that activates or increases the rate of translational initiation. BP
GO:0045999 negative regulation of ecdysteroid secretion Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of ecdysteroid. BP
GO:0045998 positive regulation of ecdysteroid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. BP
GO:0043133 hindgut contraction Constriction of the muscles in the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. BP
GO:0043132 NAD transport The directed movement of nicotinamide adenine dinucleotide into, out of, within or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH. BP
GO:0043131 enucleation The process by which nucleated precursor cells lose their nucleus during erythrocyte maturation. BP
GO:0043130 ubiquitin binding Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. MF
GO:0009870 defense response signaling pathway, resistance gene-dependent A series of molecular signals that depends upon R-genes and is activated during defense response. BP
GO:0043136 glycerol-3-phosphatase activity Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate. MF
GO:0043135 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity Catalysis of the hydrolysis of the diphosphate bond in 5-phosphoribosyl 1-pyrophosphate. MF
GO:0043134 regulation of hindgut contraction Any process that modulates the frequency, rate or extent of contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. BP
GO:0043139 5' to 3' DNA helicase activity Catalysis of the unwinding of the DNA helix in the direction 5' to 3'. MF
GO:0043138 3' to 5' DNA helicase activity Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. MF
GO:0009878 nodule morphogenesis The process by which the anatomical structures of the nodule are generated and organized. Morphogenesis pertains to the creation of form. BP
GO:0009879 determination of radial symmetry The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis. BP
GO:0042428 serotonin metabolic process The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. BP
GO:0042429 serotonin catabolic process The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. BP
GO:0042426 choline catabolic process The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. BP
GO:0042427 serotonin biosynthetic process The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. BP
GO:0042424 catecholamine catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. BP
GO:0042425 choline biosynthetic process The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. BP
GO:0042422 norepinephrine catabolic process The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. BP
GO:0042423 catecholamine biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. BP
GO:0042420 dopamine catabolic process The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. BP
GO:0042421 norepinephrine biosynthetic process The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. BP
GO:0009128 purine nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009129 pyrimidine nucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009123 nucleoside monophosphate metabolic process The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009120 deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). BP
GO:0009126 purine nucleoside monophosphate metabolic process The chemical reactions and pathways involving purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009127 purine nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009124 nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0009125 nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety. BP
GO:0050234 pyrazolylalanine synthase activity Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O. MF
GO:0050235 pyridoxal 4-dehydrogenase activity Catalysis of the reaction: pyridoxal + NAD+ = 4-pyridoxolactone + NADH. MF
GO:0050236 pyridoxine 4-dehydrogenase activity Catalysis of the reaction: pyridoxine + NADP+ = pyridoxal + NADPH. MF
GO:0050237 pyridoxine 4-oxidase activity Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2. MF
GO:0050230 purine imidazole-ring cyclase activity Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O. MF
GO:0050231 putrescine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine. MF
GO:0050232 putrescine oxidase activity Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2. MF
GO:0050233 pyranose oxidase activity Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2. MF
GO:0050238 pyridoxine 5-dehydrogenase activity Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor. MF
GO:0050239 pyrithiamine deaminase activity Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3. MF
GO:0008839 dihydrodipicolinate reductase activity Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. MF
GO:0008838 diaminopropionate ammonia-lyase activity Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3. MF
GO:0008837 diaminopimelate epimerase activity Catalysis of the reaction: LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. MF
GO:0008836 diaminopimelate decarboxylase activity Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2. MF
GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3. MF
GO:0008834 di-trans,poly-cis-decaprenylcistransferase activity Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate. MF
GO:0008833 deoxyribonuclease IV (phage-T4-induced) activity Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products. MF
GO:0008832 dGTPase activity Catalysis of the reaction: dGTP + H2O = deoxyguanosine + triphosphate. MF
GO:0008831 dTDP-4-dehydrorhamnose reductase activity Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. MF
GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose. MF
GO:0003755 peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). MF
GO:0043452 alkyne metabolic process The chemical reactions and pathways involving an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. BP
GO:0003837 beta-ureidopropionase activity Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. MF
GO:0043453 alkyne biosynthetic process The chemical reactions and pathways resulting in the formation of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms. BP
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine. MF
GO:0003832 beta-alanyl-dopamine hydrolase activity Catalysis of the conversion of beta-alanyl dopamine to dopamine (3,4-dihydroxyphenylethylamine). MF
GO:0003833 beta-alanyl-dopamine synthase activity Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine). MF
GO:0043458 ethanol biosynthetic process during fermentation The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, during the process of fermentation. BP
GO:0043459 response to short exposure to lithium ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus. BP
GO:0019378 sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by enzymes of the class EC:1.8.1.-. BP
GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8). BP
GO:0019376 galactolipid catabolic process The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. BP
GO:0019377 glycolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. BP
GO:0019374 galactolipid metabolic process The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. BP
GO:0019375 galactolipid biosynthetic process The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine. BP
GO:0019372 lipoxygenase pathway NA BP
GO:0019373 epoxygenase P450 pathway NA BP
GO:0019370 leukotriene biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. BP
GO:0019371 cyclooxygenase pathway NA BP
GO:0032638 interleukin-9 production The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032639 TRAIL production The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032634 interleukin-5 production The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032635 interleukin-6 production The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032636 interleukin-7 production The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032637 interleukin-8 production The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032630 interleukin-26 production The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032631 interleukin-27 production The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032632 interleukin-3 production The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP
GO:0032633 interleukin-4 production The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. BP